ID: hsa-mir-6758
GENE: MARS(14)
chr12:57906087-57906583+


(1)
AGO1.ip 		(1)
AGO1.ip OTHER.mut 		(5)
AGO2.ip 		(1)
AGO3.ip 		(17)
B-CELL 		(9)
BRAIN 		(20)
BREAST 		(62)
CELL-LINE 		(7)
CERVIX 		(3)
FIBROBLAST 		(8)
HEART 		(6)
HELA 		(1)
KIDNEY 		(10)
LIVER 		(2)
OTHER 		(1)
RRP40.ip 		(31)
SKIN 		(1)
TESTES 		(3)
UTERUS 		(1)
XRN.ip

Sense strand
CCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCACCTCATTGCTACAGGTAAGTACCCTGGAAGACTACTGATGGGGTGTTCATAGGAAATGAGGGGTGAGGCAGTACTTGGAAAAAGATCTTGGAGAGCTGCTATCTTGAGTTAGGAGTTGAGCTGAAATAGGAAATAATTAAAATGAGAACTCAACCTAGAGAAACGAACAAGAACCTGAAGAAAGCAAAAGTCTAAAGCTAAAACTCTTTAGTAGATATAAGCAAAGAGAAAAAAGGGCCAGAATGGATAGGAAGGGACTCCCAAAATCTGAGCATACCAGCCCCTTAAGGAGAAATGTTGCTAGACACCCATAGTTGAGGTTAGAAAGAGGAAAGAAGGAAGAGTTAGTGGGCTAGAGAGGGGAAGGATGTGATGTGAGCAGATGGTTCTCACTCATTCTCCTCTGTCCAGAGTACCTGAACTATGAGGATGGGAAATTCTCTAAGAGCCGCGGTGTGGGA
................................................................................................................................................................................................................................................................................................................................................................................................(((((...(((((((((.((.((((...((((.....)))))))))).))))))))))))))...................................................
................................................................................................................................................................................................................................................................................................................................................................................................385...........................................................447................................................
SizePerfect hitTotal NormPerfect NormSRR387910(GSM843862)
antibody for ip: Ago2. (ago2 cell line)		SRR189782SRR037939(GSM510477)
293cand5_rep1. (cell line)		SRR037940(GSM510478)
293cand5_rep2. (cell line)		SRR037944(GSM510482)
293DcrTN_cand5. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		SRR326280(GSM769510)
total cell content of unperturbed cells was s. (cell line)		SRR207113(GSM721075)
IP against AGO 1 & 2. (ago1/2 cell line)		SRR189784SRR039622(GSM531985)
HCV(+) Adjacent Tissue Sample. (liver)		SRR189787SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)		SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)		RoviraIPAgo2(Rovira)
total RNA. (ago2 breast)		SRR207114(GSM721076)
IP against AGO 1 & 2, RRP40 knockdown. (ago1/2 RRP40 cell line)		GSM1105749AGO2(GSM1105749)
small RNA sequencing data. (ago2 hela)		SRR037935(GSM510473)
293cand3. (cell line)		SRR039192(GSM494811)
K562 cell line is derived from a CML patient . (cell line)		SRR037936(GSM510474)
293cand1. (cell line)		SRR033722(GSM497067)
KMS12 cell line (KMS12). (B cell)		SRR033716(GSM497061)
Mentle Cell Lymphoma (MCL114). (B cell)		DRR000558(DRX000316)
THP-1 whole cell RNA, after 3 day treatment w. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR107297(GSM677704)
18-30nt fraction of small RNA. (cell line)		SRR326282(GSM769512)
Dicer mRNA was knocked down using siDicer, to. (cell line)		SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)		SRR037943(GSM510481)
293DcrTN. (cell line)		SRR033712(GSM497057)
Burkitt Lymphoma (BL510). (B cell)		SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)		SRR037937(GSM510475)
293cand2. (cell line)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR029127(GSM416756)
A549. (cell line)		GSM450602(GSM450602)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR342897(SRX096793)
small RNA seq of Left atrial tissue. (heart)		SRR207111(GSM721073)
Whole cell RNA. (cell line)		SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)		SRR037941(GSM510479)
293DroshaTN. (cell line)		SRR191549(GSM715659)
105genomic small RNA (size selected RNA from . (breast)		SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		SRR342898(SRX096794)
small RNA seq of Right atrial tissue. (heart)		SRR191551(GSM715661)
32genomic small RNA (size selected RNA from t. (breast)		SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)		DRR001485(DRX001039)
Hela long total cell fraction, LNA(+). (hela)		SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)		SRR094131(GSM651907)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		GSM450600(GSM450600)
miRNA sequencing raw reads from post-mortem s. (brain)		GSM1105753INPUT(GSM1105753)
small RNA sequencing data. (hela)		SRR033718(GSM497063)
Multiple Myeloma (U266). (B cell)		SRR330879(SRX091717)
tissue: skin psoriatic involveddisease state:. (skin)		SRR343332(GSM796035)
KSHV (HHV8), EBV (HHV-4). (cell line)		SRR342900(SRX096796)
small RNA seq of Right atrial tissue. (heart)		SRR038861(GSM458544)
MM466. (cell line)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		GSM956925AGO2Paz8(GSM956925)
cell line: HEK293 cell linepassages: 15-20ip . (ago2 cell line)		SRR033720(GSM497065)
EBV activated B cell line (EBV159). (B cell)		SRR207110(GSM721072)
Nuclear RNA. (cell line)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		SRR330896(SRX091734)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR330873(SRX091711)
tissue: skin psoriatic involveddisease state:. (skin)		SRR342896(SRX096792)
small RNA seq of Right atrial tissue. (heart)		SRR038854(GSM458537)
MM653. (cell line)		SRR015360(GSM380325)
Plasma B cells (PC137). (B cell)		SRR060168(GSM565978)
5-8F_nucleus. (cell line)		SRR029124(GSM416753)
HeLa. (hela)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR094130(GSM651906)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR330907(SRX091745)
tissue: normal skindisease state: normal. (skin)		SRR029125(GSM416754)
U2OS. (cell line)		SRR330888(SRX091726)
tissue: skin psoriatic uninvolveddisease stat. (skin)		GSM359208(GSM359208)
hepg2_bindASP_hl_2. (cell line)		SRR060986(GSM569190)
Human memory B cell [09-001]. (cell line)		SRR060984(GSM569188)
Human plasma cell [09-001]. (cell line)		SRR033719(GSM497064)
6hr Activated B cell line (ABC158). (B cell)		GSM450598(GSM450598)
miRNA sequencing raw reads from post-mortem s. (brain)		GSM450607(GSM450607)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR039625(GSM531988)
HBV(-) HCV(-) HCC Tissue Sample. (liver)		SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330887(SRX091725)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR191605(GSM715715)
76genomic small RNA (size selected RNA from t. (breast)		SRR037938(GSM510476)
293Red. (cell line)		DRR000556(DRX000314)
THP-1 whole cell RNA, after 3 day treatment w. (cell line)		SRR330899(SRX091737)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR038855(GSM458538)
D10. (cell line)		TAX577738(Rovira)
total RNA. (breast)		SRR189786SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		SRR189783TAX577579(Rovira)
total RNA. (breast)		SRR039613(GSM531976)
Human Normal Liver Tissue Sample 3. (liver)		SRR330893(SRX091731)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR330874(SRX091712)
tissue: skin psoriatic involveddisease state:. (skin)		SRR060983(GSM569187)
Human pre-germinal center B cell [09-001]. (cell line)		SRR330901(SRX091739)
tissue: skin psoriatic uninvolveddisease stat. (skin)		TAX577740(Rovira)
total RNA. (breast)		SRR040016(GSM532901)
G645N. (cervix)		SRR330876(SRX091714)
tissue: skin psoriatic involveddisease state:. (skin)		SRR033711(GSM497056)
GCB DLBCL (GCB110). (B cell)		SRR330894(SRX091732)
tissue: skin psoriatic uninvolveddisease stat. (skin)		GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR207112(GSM721074)
RRP40 knockdown. (RRP40 cell line)		SRR033730(GSM497075)
Lymphoblastic (ALL411). (B cell)		SRR330916(SRX091754)
tissue: normal skindisease state: normal. (skin)		SRR330884(SRX091722)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039612(GSM531975)
Human Normal Liver Tissue Sample 2. (liver)		SRR191499(GSM715609)
6genomic small RNA (size selected RNA from to. (breast)		SRR330922(SRX091760)
tissue: normal skindisease state: normal. (skin)		SRR191574(GSM715684)
78genomic small RNA (size selected RNA from t. (breast)		SRR330865(SRX091703)
tissue: skin psoriatic involveddisease state:. (skin)		SRR191548(GSM715658)
101genomic small RNA (size selected RNA from . (breast)		GSM450605(GSM450605)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR040025(GSM532910)
G613T. (cervix)		SRR029131(GSM416760)
MCF7. (cell line)		SRR330902(SRX091740)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR363673(GSM830250)
cell type: human foreskin fibroblasts (HFF)tr. (fibroblast)		GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)		DRR001489(DRX001043)
Hela short nuclear cell fraction, control. (hela)		TAX577588(Rovira)
total RNA. (breast)		SRR330919(SRX091757)
tissue: normal skindisease state: normal. (skin)		SRR330886(SRX091724)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR040035(GSM532920)
G001T. (cervix)		SRR330890(SRX091728)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR033731(GSM497076)
h929 Cell line (h929). (B cell)		SRR033729(GSM497074)
splenic MZL (Splenic414). (B cell)		DRR000561(DRX000319)
Isolation of RNA following immunoprecipitatio. (ago2 cell line)		SRR330878(SRX091716)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039617(GSM531980)
HBV(+) Adjacent Tissue Sample 1. (liver)		DRR001483(DRX001037)
Hela long cytoplasmic cell fraction, control. (hela)		SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)		SRR040010(GSM532895)
G529N. (cervix)		SRR363675(GSM830252)
cell type: human foreskin fibroblasts (HFF)tr. (fibroblast)		SRR037934(GSM510472)
293cand4_rep3. (cell line)		SRR029128(GSM416757)
H520. (cell line)		SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)		SRR207116(GSM721078)
Nuclear RNA. (cell line)		SRR040039(GSM532924)
G531T. (cervix)		SRR330866(SRX091704)
tissue: skin psoriatic involveddisease state:. (skin)		SRR038856(GSM458539)
D11. (cell line)		SRR191495(GSM715605)
159genomic small RNA (size selected RNA from . (breast)		SRR060169(GSM565979)
5-8F_cytoplasm. (cell line)		SRR037876(GSM522374)
fibroblasts_cell_culture. (fibroblast)		SRR191598(GSM715708)
79genomic small RNA (size selected RNA from t. (breast)		SRR191550(GSM715660)
27genomic small RNA (size selected RNA from t. (breast)		SRR330895(SRX091733)
tissue: skin psoriatic uninvolveddisease stat. (skin)		DRR000557(DRX000315)
THP-1 whole cell RNA, after 3 day treatment w. (cell line)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		SRR191622(GSM715732)
175genomic small RNA (size selected RNA from . (breast)		SRR039635(GSM518472)
THP1_nuc_sRNAs. (cell line)		SRR039619(GSM531982)
HBV(+) HCC Tissue Sample 1. (liver)		SRR191553(GSM715663)
96genomic small RNA (size selected RNA from t. (breast)		SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR191399(GSM715509)
36genomic small RNA (size selected RNA from t. (breast)		SRR330921(SRX091759)
tissue: normal skindisease state: normal. (skin)		SRR553576(SRX182782)
source: Testis. (testes)		SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)		SRR037933(GSM510471)
293cand4_rep2. (cell line)		SRR039637(GSM518474)
THP1_total_sRNAs. (cell line)		SRR553575(SRX182781)
source: Kidney. (Kidney)		SRR038859(GSM458542)
MM386. (cell line)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR191554(GSM715664)
99genomic small RNA (size selected RNA from t. (breast)		SRR039621(GSM531984)
HBV(+) HCC Tissue Sample 2. (liver)		SRR343333(GSM796036)
KSHV (HHV8). (cell line)		SRR342901(SRX096797)
small RNA seq of Left atrial tissue. (heart)		SRR095854(SRX039177)
miRNA were isolated from FirstChoice Human Br. (brain)		SRR207117(GSM721079)
Whole cell RNA. (cell line)		SRR330918(SRX091756)
tissue: normal skindisease state: normal. (skin)		SRR330911(SRX091749)
tissue: normal skindisease state: normal. (skin)		SRR330867(SRX091705)
tissue: skin psoriatic involveddisease state:. (skin)		DRR000562(DRX000320)
Isolation of RNA following immunoprecipitatio. (ago3 cell line)		SRR038862(GSM458545)
MM472. (cell line)		SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR040012(GSM532897)
G648N. (cervix)		SRR029129(GSM416758)
SW480. (cell line)		SRR553574(SRX182780)
source: Heart. (Heart)		SRR330864(SRX091702)
tissue: skin psoriatic involveddisease state:. (skin)		SRR060985(GSM569189)
Human naive B cell [09-001]. (cell line)		GSM450603(GSM450603)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR330859(SRX091697)
tissue: skin psoriatic involveddisease state:. (skin)		SRR191597(GSM715707)
75genomic small RNA (size selected RNA from t. (breast)		SRR330920(SRX091758)
tissue: normal skindisease state: normal. (skin)		SRR189785SRR191525(GSM715635)
121genomic small RNA (size selected RNA from . (breast)		SRR040028(GSM532913)
G026N. (cervix)		SRR189777(GSM714637)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR342894(SRX096790)
small RNA seq of Right atrial tissue. (heart)
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGT.................................................211130.0016.0013.005.0014.009.009.00-8.001.002.00---3.002.002.002.005.00-3.00--2.002.00-2.00-4.00--2.00--1.002.00--3.00---------1.001.001.00--1.00--------2.00-----2.00-1.001.00--1.00--1.00-1.00--2.00---------1.00----1.00--1.00----1.00----1.00---1.00-1.00------1.00---1.00-----1.00------1.00-1.00-----1.00----1.00----------------1.00---1.001.00--1.00--1.00------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGA.................................................21148.0048.0013.001.00--4.00-1.006.00---7.00--5.00-------------------------2.00----------1.00-------1.00----------------------1.00-----------------------------------------1.00--1.00---------------1.00-----------------------1.00------1.00-----1.00-----
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGT.....................................................................................23133.0033.009.00----4.001.00-----1.00-------3.00--2.00------1.00-----------2.00-------------------2.001.00------------2.00--------------------1.00-------------------------1.00--1.00---------------------1.00----------------------------1.00--------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTGA...................................................................................25126.0026.0016.00----2.00---------------1.00-------------1.00----------------------2.00------1.00-1.00----------------------------------------------------------------------------1.00-------------------------1.00---------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTAT...................................................................................25126.0033.005.00-7.0012.00---------------2.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAG..................................................20116.0016.00-11.00----------1.00------------------------------------------------------------------1.00-------1.00-----1.00------------------------------------1.00-------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGATGTGA...................................................................................24116.0016.002.00----2.00---------1.00---------3.00----------------------------1.00--------------------1.00-----------------------------------------1.00--------------1.001.00-----1.00----------------------1.00------1.00----------------
.........................................................................................................................................................................................................................................................................................................................................................................................................................................TCACTCATTCTCCTCTGTCCAGT.................................................23115.009.007.001.00-----------------------------4.00------------------1.00-----------------1.00------------------------------------1.00--------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTTG..................................................................................................................................................................................................................................................................................................................................................................................................................................19412.251.50-10.00------0.75-0.25---0.25-----------------0.25-0.25-----------0.25----------------------------------------0.25--------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTG....................................................................................24112.0012.002.00----------------1.00-----------------1.00------------------1.00------1.00--------1.00---------------------1.00-----------------------1.00-----1.00------1.00-------1.00------------------------------------------------
.......................................................................................................................................................................................................................................................................................................................................................................................................GAGAGGGGAAGGATGTGATGTGA...................................................................................23112.0012.009.00------------------1.00----------------------------------------------------------------1.00-----------------------------------1.00-----------------------------------------------------------------
.......................................................................................................................GATCTTGGAGAGCTGAGC........................................................................................................................................................................................................................................................................................................................................................................1810.000.00-------------------------------------3.00---2.00-----------------------------------------------------------------1.00-1.00--------------------------------1.00------1.00----------1.00-------------------------
.........................................................................................................................................................................................................................................................................................................................................................................................................................................TCACTCATTCTCCTCTGTCCAG..................................................2219.009.001.00------4.00--------1.00-1.00--------------1.00---------------1.00----------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATG......................................................................................2217.007.001.00-------2.00--------------------------------------------------------------------------------1.00-----------1.00-----------------------------------------------------------1.00---1.00--------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTGT...................................................................................2517.0012.00------------------1.001.00---1.00----------------------------1.00--------1.00---1.00-1.00----------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGC.................................................2114.0016.00------------------------1.00---------------1.00--------1.00---------1.00------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................................................................................................................................................................................................................................................................................................................GGAAGGATGTGATGTGAGCAGATGG...........................................................................2514.004.00-------------------------------------------------------2.00-----------------2.00----------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGATGTG....................................................................................2314.004.00----------------------------------1.00-------------------------------------1.00--------------------------------------------------------------------1.00--------------1.00-----------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGAT.......................................................................................2114.004.00----------------------------------1.00---------------1.00-------------------1.00-------------1.00-----------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTCTG..................................................................................................................................................................................................................................................................................................................................................................................................................................1943.251.50-0.50------1.75-1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................................................................................................................................................................................................................................................................................................................................CTCATTCTCCTCTGTCCAA..................................................193.000.00---------------3.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...AGGAGCTGAGGATAACTATA..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................2013.003.00---------------------------3.00--------------------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGA........................................................................................2013.003.00--------------------------------------1.00-----------------------------------1.00-------------------------1.00-------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGATGT.....................................................................................2213.003.00--------------------------------------1.00-------------1.00-----------------------------------------------------------------------------------------------------1.00-------------------------------
................................................................................................................................................................................................................................................................................................................................................................................................TGGGCTAGAGAGGGGAAGGATGT..........................................................................................2313.003.002.00-------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------
........................................................................................................................................................................................................................................................................................................................................................................................................................................CTCACTCATTCTCCTCTGTCCAG..................................................2313.003.00-----------------1.00-----------------------------------------------------1.00--------------------------------------------------------------1.00---------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGA........................................................................................1913.003.00----------------------------------------------------------------2.00------------------1.00------------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................CAACCTAGAGAAACGAACAAGAACCTGAAGAAAGC....................................................................................................................................................................................................................................................................................3513.003.00-------------3.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
................................................................................................................................................................................................................................................................................................................................................................................................TGGGCTAGAGAGGGGAAGGAT............................................................................................2113.003.00-----------1.001.00-----------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCATT.................................................2113.001.00----------------1.00------------------------------------------------------1.00-----------------------------------------------------------------------------------1.00------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGCG....................................................................................2413.007.00----------2.00--------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................................................................................................................................................................................................................AGTTAGTGGGCTAGAGAGGGGAAGGATGTGATGTGAGCAGATGGTTCTCACTCATTCTCCTCTGTCCAG..................................................6913.003.00-------------------------------------------3.00----------------------------------------------------------------------------------------------------------------------------------------------
..TAGGAGCTGAGGATAACTATAC.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................2213.003.00---------2.00----------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTCG..................................................................................................................................................................................................................................................................................................................................................................................................................................1942.251.50-0.75------1.00----------------------------------------------------------------------------0.25-----------------------------------------------------------------------------------------------0.25----
......................................................................................................................................................................................................................................................GTAGATATAAGCAAAGA..........................................................................................................................................................................................................................................1722.002.00--------------------------------------------------------2.00---------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................................................................................................................................................................................................................................................................CACTCATTCTCCTCTGTCCAGT.................................................222.000.00----------------------------------------------1.00---------------------------------------------------------------------------------------------------------------------1.00---------------------
..TAGGAGCTGAGGATAACTA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................1912.002.00---------1.00----------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGG.................................................2112.0016.00-1.00--------------------------------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------
.........................................................................................................................................................................................................................................................................................................................................................................................................................................TCACTCATTCTCCTCTGTCCAT..................................................222.000.00---------------------------------------------------------------------------------------------------1.00----------1.00---------------------------------------------------------------------------
................................................................................................................................................................................................................................................................................................................................................................................................TGGGCTAGAGAGGGGAAGGATGTGA........................................................................................2512.002.00------1.00--------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATA......................................................................................2212.004.00---------------------------------------------2.00--------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATATA....................................................................................2412.004.00----------------------------2.00-------------------------------------------------------------------------------------------------------------------------------------------------------------
..TAGGAGCTGAGGATAACTATACC........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................2312.002.00----------------------1.00--------------------------------------------------------------------------------------------------------------------------1.00----------------------------------------
............................................................TGGAAGACTACTGAT......................................................................................................................................................................................................................................................................................................................................................................................................................................1541.501.50----------1.25--------------------------------------------------------------------------0.25----------------------------------------------------------------------------------------------------
...AGGAGCTGAGGATAACT.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................1721.501.50-----1.50------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTG...................................................................................................................................................................................................................................................................................................................................................................................................................................1841.251.50-1.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGGATGGGAAATTCTCTAAGAGCCGCGG.......2811.001.00-------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................................................................................................................................................................................................................................................................................................................................................CAGAGTACCTGAACTATGAGGATGGG...........................2611.001.00----------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGGATGGGAAATTCTCTAAGAGCCGCGGTGTGGG.3411.001.00-------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................................ACAAGAACCTGAAGAAAGCAA..................................................................................................................................................................................................................................................................................2111.001.00------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------
...AGGAGCTGAGGATAACTATACCTT......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................2411.001.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
....................................................................................................................................................................................................................................................................................................................................................................................................................................................................CTGAACTATGAGGATGGG...........................1811.001.00---------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------
......................................................GTACCCTGGAAGACTACTG........................................................................................................................................................................................................................................................................................................................................................................................................................................1911.001.00----------------------------------------------------------------------------------------------------------1.00-------------------------------------------------------------------------------
............................................................................................................................................................................................................................................................................................................................................................................................................................................CTCATTCTCCTCTGTCCAG..................................................1911.001.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGA.....................................................................................2311.007.00---------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................CAACCTAGAGAAACGAACAAGAACCTGAAGAA.......................................................................................................................................................................................................................................................................................3211.001.00----------------------------------------------------------------------------------------------------------------------------------------1.00-------------------------------------------------
...............................................................................................................................................................................................TAGAGAAACGAACAAGAACCTGAAGA........................................................................................................................................................................................................................................................................................2611.001.00---------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................GTGGGCTAGAGAGGGGAAGGATGTGT........................................................................................261.000.00-------------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................AGATCTTGGAGAGCTGAGC........................................................................................................................................................................................................................................................................................................................................................................191.000.00-----------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTGAAA.................................................................................2711.0026.00-------------------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................................................TTCTCACTCATTCTCCTCTGTCCA...................................................2411.001.00-------------------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------
................................................................................................................................................................................................................................................................................................................................................................................AAGAAGGAAGAGTTAGTAGGA............................................................................................................211.000.00---------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTTTTT.................................................................................2711.0033.00-----1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................................................................................................................................................................................................................................................................................................................................ACCTGAACTATGAGGATGG............................1911.001.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................GTTAGGAGTTGAGCTGAA................................................................................................................................................................................................................................................................................................................................................1811.001.00-----------------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................GTGGGCTAGAGAGGGGAAGGATGTGAT.......................................................................................2711.001.00-----------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGTT................................................2211.0016.00------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................................................................................................................................................................................................................................................................................................TCTCACTCATTCTCCTCTGTCCAGA.................................................2511.001.00------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------
..................................................................................................................................................................................................................................................................................................................................................................................................................................ATGGTTCTCACTCATTCTCCTCTGTCCAG..................................................2911.001.00---------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGCT................................................2211.0016.00----------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................................................................................................................................................................................................................................................................................................................TACCTGAACTATGAGGATGG............................2011.001.00------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................................AAGGATGTGATGTGAGCACC..............................................................................201.000.00---------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................GAACTCAACCTAGAGAAACGA.......................................................................................................................................................................................................................................................................................................2111.001.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00-------
................................................................................................................................................................................................................................................................................................................................................................................................TGGGCTAGAGAGGGGAAGGATGA..........................................................................................231.000.00------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................AACCTAGAGAAACGAACAAGAAC...............................................................................................................................................................................................................................................................................................2311.001.00----------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGATTGTT...................................................................................241.000.00-----------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................................................................................................AAGAACCTGAAGAAAGCAAAAGTC.............................................................................................................................................................................................................................................................................2411.001.00-----------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AAGAGCCGCGGTGTGGGAGTGC221.000.00-----------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------
................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGAGCCGCGGTGTGGGA1711.001.00-------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................GTGGGCTAGAGAGGGGAAGGATG...........................................................................................2311.001.00--------------------------------------------------------------------------------------1.00---------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTAG...................................................................................2511.0033.00------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGAT................................................2211.0048.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.CTAGGAGCTGAGGATAACTATACC........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................2411.001.00------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGTAA......................................................................................221.000.00--------------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGACGTG....................................................................................2411.003.00----------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCATT..................................................201.000.00-------------------------------------------------------------------------------------------------------------------1.00----------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................TAGAGAGGGGAAGGATGTGATGTGAA..................................................................................2611.0026.00------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATGTTG..................................................................................................................................................................................................................................................................................................................................................................................................................................191.000.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................................................................................................................................................................................................................................................................GAGAGGGGAAGGATGTGATGGGA...................................................................................231.000.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................GTGGGCTAGAGAGGGGAAGGATGCGA........................................................................................2611.001.00---------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------
.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ATGGGAAATTCTCTAAGAGCCGC.........2311.001.00--------------------------------------------------------------------------------------------------------------------------------------------------------1.00---------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................................AAGGATGTGATGTGAGTCA...............................................................................191.000.00---------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................AAATGAGAACTCAACCTAGAGAAACGA.......................................................................................................................................................................................................................................................................................................2711.001.00----------------------------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------
........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ACTATGAGGATGGGAAATT......................1911.001.00------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCAGTAAT..............................................2411.0016.00---------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................AACGAACAAGAACCTGAAGAAAGCAAAAGTCT............................................................................................................................................................................................................................................................................3211.001.00---------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................ACGAACAAGAACCTGAAGAAAGCAA..................................................................................................................................................................................................................................................................................2511.001.00--------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTAAGTACCCTGGAAGACTA...........................................................................................................................................................................................................................................................................................................................................................................................................................................2011.001.00---------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................................................................................................................................................................................................................................................................CCTGAACTATGAGGATGG............................1811.001.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00-------------------
....................................................................................................................................................................................................................................................................................................................................................................................................................................................................CTGAACTATGAGGATGGGAAATT......................2311.001.00---------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................TGAAGAAAGCAAAAGTAG............................................................................................................................................................................................................................................................................181.000.00-----1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................................................................................................................................................................................................................................................................................................................................................CAGAGTACCTGAACTATGAGGATGGGT..........................2711.001.00-------------------------------------------------------------------------------------------------------------------------------------------------------------1.00----------------------------
............................................................TGGAAGACTACTGATGTTC..................................................................................................................................................................................................................................................................................................................................................................................................................................191.000.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................................................................................................................................................................................................................................................AGTGGGCTAGAGAGGGGAAGGA.............................................................................................2211.001.00------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGAA.......................................................................................2011.003.00--------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------
........................................................................................................................................................................................................GAACAAGAACCTGAAGAAG......................................................................................................................................................................................................................................................................................191.000.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
........................................................................................................................................................................................................................................................................................................................................................................................................................................CTCACTCATTCTCCTCTGTCCAGA.................................................2411.001.00------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................................................................................................................................................................................................................................TGGTTCTCACTCATTCTCCTCTGTCCAG..................................................2811.001.00-----------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................................................................................................................................................................................................................................................................CCTGAACTATGAGGATGGG...........................1911.001.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................................................................................................................................................................................................................................................................................................................TACCTGAACTATGAGGATG.............................1911.001.00-----------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCAAGG.................................................211.000.00-----------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................................................................................................................................................................................................................................................................GTGGGCTAGAGAGGGGAAGGATGT..........................................................................................2411.001.00--------------------------------------------------------------------------------------------------------------------------------------------------------------1.00---------------------------
..TAGGAGCTGAGGATAAC..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................1711.001.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00----------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGAACTATGAGGATGGGAAATTT.....................231.000.00---------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................................................................AACAAGAACCTGAAGAATA.....................................................................................................................................................................................................................................................................................191.000.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
................................................................................................................................................................................AATGAGAACTCAACCTAACC.............................................................................................................................................................................................................................................................................................................201.000.00-----------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................................................................................................................................................................................AGGGCCAGAATGGATAGGAAGG..............................................................................................................................................................................................................2211.001.00--------------------------------------------------------------------------------------------------------------------------------1.00---------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTCCA...................................................1911.001.00------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................................................................AACAAGAACCTGAAGAAAGCA...................................................................................................................................................................................................................................................................................2111.001.00----------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................TCATAGGAAATGAGGAC..............................................................................................................................................................................................................................................................................................................................................................................................................171.000.00------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------
..................................................................................................................................................................................................................................................................................................................................................................................................................................................................ACCTGAACTATGAGGATGGGAAATTCTCT..................2911.001.00-----------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................................................................................................................................................................................................................................................................................................TCACTCATTCTCCTCTGTCC....................................................2011.001.00----------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................................................................................................................................................................................................................................................................................................TCACTCATTCTCCTCTGTCCAGTT................................................2411.009.00---------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................................................................................................................................................................................................................................................GGGCTAGAGAGGGGAAGGGGC...........................................................................................211.000.00-----------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGATGCGA...................................................................................2411.001.00----------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................................................................AACAAGAACCTGAAGAAAGCAAAAGTC.............................................................................................................................................................................................................................................................................2711.001.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................ACGAACAAGAACCTGAAGAAAGCA...................................................................................................................................................................................................................................................................................2411.001.00--------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................................................................................................................................................................................................................................................................GAGAGGGGAAGGATGTGATGCGA...................................................................................231.000.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................GAAACGAACAAGAACCTGAAGAAAGCAAAAGT..............................................................................................................................................................................................................................................................................3211.001.00-----------------------------------------------------------------------------------------------------------------1.00------------------------------------------------------------------------
..................................................................................................................................................................................................................................................................................................................................................................................................................................................................ACCTGAACTATGAGGATGGGAAATT......................2511.001.00--------------------------------------------------------------------------------------------------------1.00---------------------------------------------------------------------------------
...........................................................................................................................................................................................AACCTAGAGAAACGAACAAGAACCTGA...........................................................................................................................................................................................................................................................................................2711.001.00----------------------------------------------------------------------------------------------------------------------1.00-------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................AGAAAGAGGAAAGAAGGAGGAA.....................................................................................................................221.000.00-----1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTGATG......................................................................................2111.001.00---------------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------
................................................................................................................................................................................................AGAGAAACGAACAAGAACCTGAAGAAAGCAAAAGT..............................................................................................................................................................................................................................................................................3511.001.00-------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..TAGGAGCTGAGGATAACTATACCTT......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................2511.001.00--------------------------------------------------------------------------1.00---------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGAACTATGAGGATGGGAAATTC.....................2311.001.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00----------
...AGGAGCTGAGGATAACTA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................1811.001.00---------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................................................................................................................................................................................................................................................................................................ACTCATTCTCCTCTGTACAG..................................................201.000.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATCTTG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.751.50--------0.50----------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.25----
............................................................TGGAAGACTACTGATTTT...................................................................................................................................................................................................................................................................................................................................................................................................................................1840.751.50-0.50------------------------------0.25---------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTTA..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.501.50-0.50----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATCTGG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.501.50--------0.25-0.25-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGAACTATGAGGATGGAGGC........................2020.500.50--------------------------------------------0.50---------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGAGGATGGGAAATTCTC...................1820.500.50--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.50---
............................................................TGGAAGACTACTGATTTTT..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.501.50-0.25-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.25----
.......GCTGAGGATAACTATACC........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................1820.500.50----------------------0.50-------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATACTG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.501.50--------0.50---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGAACTATGAGGATGG............................1620.500.50---------------------------------0.50--------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATCTCG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.501.50--------0.50---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................................................................................................................................................................................................................................................................GAAGGATGTGATGTGA...................................................................................1650.400.400.40-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAGGATGGGAAATTCTCT..................1830.330.33--------------------------------------------------------------------------------------0.33---------------------------------------------------------------------------------------------------
......................................................................................................................................................................................................................................................................................................................................................................................................AGAGAGGGGAAGGATGTG.........................................................................................1830.330.33---------------------------------------------0.33--------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTATG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50--------0.25---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTCCG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50----------0.25-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATATTG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50--------0.25---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATCGTG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50--------0.25---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATCCTG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50-0.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................................................................................................................................................................GTTAGAAAGAGGAAAGAA............................................................................................................................1840.250.25---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.25--
............................................................TGGAAGACTACTGATTAG...................................................................................................................................................................................................................................................................................................................................................................................................................................1840.251.50-0.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATATAG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50----------0.25-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATCTTT..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50-0.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTCTA..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50--------0.25---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTGG..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50-0.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTA...................................................................................................................................................................................................................................................................................................................................................................................................................................1840.251.50-0.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................TGGAAGACTACTGATTTTC..................................................................................................................................................................................................................................................................................................................................................................................................................................1940.251.50-0.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Antisense strand
CCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCACCTCATTGCTACAGGTAAGTACCCTGGAAGACTACTGATGGGGTGTTCATAGGAAATGAGGGGTGAGGCAGTACTTGGAAAAAGATCTTGGAGAGCTGCTATCTTGAGTTAGGAGTTGAGCTGAAATAGGAAATAATTAAAATGAGAACTCAACCTAGAGAAACGAACAAGAACCTGAAGAAAGCAAAAGTCTAAAGCTAAAACTCTTTAGTAGATATAAGCAAAGAGAAAAAAGGGCCAGAATGGATAGGAAGGGACTCCCAAAATCTGAGCATACCAGCCCCTTAAGGAGAAATGTTGCTAGACACCCATAGTTGAGGTTAGAAAGAGGAAAGAAGGAAGAGTTAGTGGGCTAGAGAGGGGAAGGATGTGATGTGAGCAGATGGTTCTCACTCATTCTCCTCTGTCCAGAGTACCTGAACTATGAGGATGGGAAATTCTCTAAGAGCCGCGGTGTGGGA
................................................................................................................................................................................................................................................................................................................................................................................................(((((...(((((((((.((.((((...((((.....)))))))))).))))))))))))))...................................................
................................................................................................................................................................................................................................................................................................................................................................................................385...........................................................447................................................
SizePerfect hitTotal NormPerfect NormSRR387910(GSM843862)
antibody for ip: Ago2. (ago2 cell line)		SRR189782SRR037939(GSM510477)
293cand5_rep1. (cell line)		SRR037940(GSM510478)
293cand5_rep2. (cell line)		SRR037944(GSM510482)
293DcrTN_cand5. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		SRR326280(GSM769510)
total cell content of unperturbed cells was s. (cell line)		SRR207113(GSM721075)
IP against AGO 1 & 2. (ago1/2 cell line)		SRR189784SRR039622(GSM531985)
HCV(+) Adjacent Tissue Sample. (liver)		SRR189787SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)		SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)		RoviraIPAgo2(Rovira)
total RNA. (ago2 breast)		SRR207114(GSM721076)
IP against AGO 1 & 2, RRP40 knockdown. (ago1/2 RRP40 cell line)		GSM1105749AGO2(GSM1105749)
small RNA sequencing data. (ago2 hela)		SRR037935(GSM510473)
293cand3. (cell line)		SRR039192(GSM494811)
K562 cell line is derived from a CML patient . (cell line)		SRR037936(GSM510474)
293cand1. (cell line)		SRR033722(GSM497067)
KMS12 cell line (KMS12). (B cell)		SRR033716(GSM497061)
Mentle Cell Lymphoma (MCL114). (B cell)		DRR000558(DRX000316)
THP-1 whole cell RNA, after 3 day treatment w. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR107297(GSM677704)
18-30nt fraction of small RNA. (cell line)		SRR326282(GSM769512)
Dicer mRNA was knocked down using siDicer, to. (cell line)		SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)		SRR037943(GSM510481)
293DcrTN. (cell line)		SRR033712(GSM497057)
Burkitt Lymphoma (BL510). (B cell)		SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)		SRR037937(GSM510475)
293cand2. (cell line)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR029127(GSM416756)
A549. (cell line)		GSM450602(GSM450602)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR342897(SRX096793)
small RNA seq of Left atrial tissue. (heart)		SRR207111(GSM721073)
Whole cell RNA. (cell line)		SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)		SRR037941(GSM510479)
293DroshaTN. (cell line)		SRR191549(GSM715659)
105genomic small RNA (size selected RNA from . (breast)		SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		SRR342898(SRX096794)
small RNA seq of Right atrial tissue. (heart)		SRR191551(GSM715661)
32genomic small RNA (size selected RNA from t. (breast)		SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)		DRR001485(DRX001039)
Hela long total cell fraction, LNA(+). (hela)		SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)		SRR094131(GSM651907)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		GSM450600(GSM450600)
miRNA sequencing raw reads from post-mortem s. (brain)		GSM1105753INPUT(GSM1105753)
small RNA sequencing data. (hela)		SRR033718(GSM497063)
Multiple Myeloma (U266). (B cell)		SRR330879(SRX091717)
tissue: skin psoriatic involveddisease state:. (skin)		SRR343332(GSM796035)
KSHV (HHV8), EBV (HHV-4). (cell line)		SRR342900(SRX096796)
small RNA seq of Right atrial tissue. (heart)		SRR038861(GSM458544)
MM466. (cell line)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		GSM956925AGO2Paz8(GSM956925)
cell line: HEK293 cell linepassages: 15-20ip . (ago2 cell line)		SRR033720(GSM497065)
EBV activated B cell line (EBV159). (B cell)		SRR207110(GSM721072)
Nuclear RNA. (cell line)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		SRR330896(SRX091734)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR330873(SRX091711)
tissue: skin psoriatic involveddisease state:. (skin)		SRR342896(SRX096792)
small RNA seq of Right atrial tissue. (heart)		SRR038854(GSM458537)
MM653. (cell line)		SRR015360(GSM380325)
Plasma B cells (PC137). (B cell)		SRR060168(GSM565978)
5-8F_nucleus. (cell line)		SRR029124(GSM416753)
HeLa. (hela)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR094130(GSM651906)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR330907(SRX091745)
tissue: normal skindisease state: normal. (skin)		SRR029125(GSM416754)
U2OS. (cell line)		SRR330888(SRX091726)
tissue: skin psoriatic uninvolveddisease stat. (skin)		GSM359208(GSM359208)
hepg2_bindASP_hl_2. (cell line)		SRR060986(GSM569190)
Human memory B cell [09-001]. (cell line)		SRR060984(GSM569188)
Human plasma cell [09-001]. (cell line)		SRR033719(GSM497064)
6hr Activated B cell line (ABC158). (B cell)		GSM450598(GSM450598)
miRNA sequencing raw reads from post-mortem s. (brain)		GSM450607(GSM450607)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR039625(GSM531988)
HBV(-) HCV(-) HCC Tissue Sample. (liver)		SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330887(SRX091725)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR191605(GSM715715)
76genomic small RNA (size selected RNA from t. (breast)		SRR037938(GSM510476)
293Red. (cell line)		DRR000556(DRX000314)
THP-1 whole cell RNA, after 3 day treatment w. (cell line)		SRR330899(SRX091737)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR038855(GSM458538)
D10. (cell line)		TAX577738(Rovira)
total RNA. (breast)		SRR189786SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		SRR189783TAX577579(Rovira)
total RNA. (breast)		SRR039613(GSM531976)
Human Normal Liver Tissue Sample 3. (liver)		SRR330893(SRX091731)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR330874(SRX091712)
tissue: skin psoriatic involveddisease state:. (skin)		SRR060983(GSM569187)
Human pre-germinal center B cell [09-001]. (cell line)		SRR330901(SRX091739)
tissue: skin psoriatic uninvolveddisease stat. (skin)		TAX577740(Rovira)
total RNA. (breast)		SRR040016(GSM532901)
G645N. (cervix)		SRR330876(SRX091714)
tissue: skin psoriatic involveddisease state:. (skin)		SRR033711(GSM497056)
GCB DLBCL (GCB110). (B cell)		SRR330894(SRX091732)
tissue: skin psoriatic uninvolveddisease stat. (skin)		GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR207112(GSM721074)
RRP40 knockdown. (RRP40 cell line)		SRR033730(GSM497075)
Lymphoblastic (ALL411). (B cell)		SRR330916(SRX091754)
tissue: normal skindisease state: normal. (skin)		SRR330884(SRX091722)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039612(GSM531975)
Human Normal Liver Tissue Sample 2. (liver)		SRR191499(GSM715609)
6genomic small RNA (size selected RNA from to. (breast)		SRR330922(SRX091760)
tissue: normal skindisease state: normal. (skin)		SRR191574(GSM715684)
78genomic small RNA (size selected RNA from t. (breast)		SRR330865(SRX091703)
tissue: skin psoriatic involveddisease state:. (skin)		SRR191548(GSM715658)
101genomic small RNA (size selected RNA from . (breast)		GSM450605(GSM450605)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR040025(GSM532910)
G613T. (cervix)		SRR029131(GSM416760)
MCF7. (cell line)		SRR330902(SRX091740)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR363673(GSM830250)
cell type: human foreskin fibroblasts (HFF)tr. (fibroblast)		GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)		DRR001489(DRX001043)
Hela short nuclear cell fraction, control. (hela)		TAX577588(Rovira)
total RNA. (breast)		SRR330919(SRX091757)
tissue: normal skindisease state: normal. (skin)		SRR330886(SRX091724)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR040035(GSM532920)
G001T. (cervix)		SRR330890(SRX091728)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR033731(GSM497076)
h929 Cell line (h929). (B cell)		SRR033729(GSM497074)
splenic MZL (Splenic414). (B cell)		DRR000561(DRX000319)
Isolation of RNA following immunoprecipitatio. (ago2 cell line)		SRR330878(SRX091716)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039617(GSM531980)
HBV(+) Adjacent Tissue Sample 1. (liver)		DRR001483(DRX001037)
Hela long cytoplasmic cell fraction, control. (hela)		SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)		SRR040010(GSM532895)
G529N. (cervix)		SRR363675(GSM830252)
cell type: human foreskin fibroblasts (HFF)tr. (fibroblast)		SRR037934(GSM510472)
293cand4_rep3. (cell line)		SRR029128(GSM416757)
H520. (cell line)		SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)		SRR207116(GSM721078)
Nuclear RNA. (cell line)		SRR040039(GSM532924)
G531T. (cervix)		SRR330866(SRX091704)
tissue: skin psoriatic involveddisease state:. (skin)		SRR038856(GSM458539)
D11. (cell line)		SRR191495(GSM715605)
159genomic small RNA (size selected RNA from . (breast)		SRR060169(GSM565979)
5-8F_cytoplasm. (cell line)		SRR037876(GSM522374)
fibroblasts_cell_culture. (fibroblast)		SRR191598(GSM715708)
79genomic small RNA (size selected RNA from t. (breast)		SRR191550(GSM715660)
27genomic small RNA (size selected RNA from t. (breast)		SRR330895(SRX091733)
tissue: skin psoriatic uninvolveddisease stat. (skin)		DRR000557(DRX000315)
THP-1 whole cell RNA, after 3 day treatment w. (cell line)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		SRR191622(GSM715732)
175genomic small RNA (size selected RNA from . (breast)		SRR039635(GSM518472)
THP1_nuc_sRNAs. (cell line)		SRR039619(GSM531982)
HBV(+) HCC Tissue Sample 1. (liver)		SRR191553(GSM715663)
96genomic small RNA (size selected RNA from t. (breast)		SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR191399(GSM715509)
36genomic small RNA (size selected RNA from t. (breast)		SRR330921(SRX091759)
tissue: normal skindisease state: normal. (skin)		SRR553576(SRX182782)
source: Testis. (testes)		SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)		SRR037933(GSM510471)
293cand4_rep2. (cell line)		SRR039637(GSM518474)
THP1_total_sRNAs. (cell line)		SRR553575(SRX182781)
source: Kidney. (Kidney)		SRR038859(GSM458542)
MM386. (cell line)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR191554(GSM715664)
99genomic small RNA (size selected RNA from t. (breast)		SRR039621(GSM531984)
HBV(+) HCC Tissue Sample 2. (liver)		SRR343333(GSM796036)
KSHV (HHV8). (cell line)		SRR342901(SRX096797)
small RNA seq of Left atrial tissue. (heart)		SRR095854(SRX039177)
miRNA were isolated from FirstChoice Human Br. (brain)		SRR207117(GSM721079)
Whole cell RNA. (cell line)		SRR330918(SRX091756)
tissue: normal skindisease state: normal. (skin)		SRR330911(SRX091749)
tissue: normal skindisease state: normal. (skin)		SRR330867(SRX091705)
tissue: skin psoriatic involveddisease state:. (skin)		DRR000562(DRX000320)
Isolation of RNA following immunoprecipitatio. (ago3 cell line)		SRR038862(GSM458545)
MM472. (cell line)		SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR040012(GSM532897)
G648N. (cervix)		SRR029129(GSM416758)
SW480. (cell line)		SRR553574(SRX182780)
source: Heart. (Heart)		SRR330864(SRX091702)
tissue: skin psoriatic involveddisease state:. (skin)		SRR060985(GSM569189)
Human naive B cell [09-001]. (cell line)		GSM450603(GSM450603)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR330859(SRX091697)
tissue: skin psoriatic involveddisease state:. (skin)		SRR191597(GSM715707)
75genomic small RNA (size selected RNA from t. (breast)		SRR330920(SRX091758)
tissue: normal skindisease state: normal. (skin)		SRR189785SRR191525(GSM715635)
121genomic small RNA (size selected RNA from . (breast)		SRR040028(GSM532913)
G026N. (cervix)		SRR189777(GSM714637)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR342894(SRX096790)
small RNA seq of Right atrial tissue. (heart)
..............................................................................................................................................................................................................................................................................................................................................................................................................................................CATTCTCCTCTGTCCAGA................................................. 1811.001.00---------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------
.....................................................................................................................................................................................................................................................................GAGAAAAAAGGGCCAGCCT......................................................................................................................................................................................................................... 191.000.00-----------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................................................................................................................................................................................................................................................TCCTCTGTCCAGAGTAAC............................................ 181.000.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................CCACCTCATTGCTACAGG.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 1811.001.00-----------------------------------------------------------------------------------------------------------------------1.00------------------------------------------------------------------
..................................................................................................................................................................................................................................................................AAAGAGAAAAAAGGGCCATTCT......................................................................................................................................................................................................................... 221.000.00------------------------------------------------------------------------------------------------------------------------------------------------------1.00-----------------------------------
..........................................................................................................................................CTTGAGTTAGGAGTTGAGCTGAAATAGGAAATA...................................................................................................................................................................................................................................................................................................................................... 3311.001.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------
.....................................CTCATTGCTACAGGTTGC.......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 181.000.00----------------------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................................................................................................................................................................................................................................................................................TCCTCTGTCCAGAGTACCT........................................... 1911.001.00-----------------------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------
....................................CCTCATTGCTACAGGT............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 1620.500.50------0.50-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................................................CTAGAGAAACGAAC..................................................................................................................................................................................................................................................................................................... 1440.250.25-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.25
.............................................................................................................................................................................................................................................................................................................................................................................GGAAAGAAGGAAGAGTTA.................................................................................................................. 1840.250.25----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.25-