ID: mmu-mir-6418
GENE: Gnb2(6)
chr5:137970688-137970880-


(1)
AGO.mut 		(2)
AGO1.ip 		(21)
AGO2.ip 		(2)
AGO3.ip 		(11)
B-CELL 		(39)
BRAIN 		(12)
CELL-LINE 		(3)
DCR.mut 		(3)
DGCR8.mut 		(16)
EMBRYO 		(9)
ESC 		(8)
FIBROBLAST 		(8)
HEART 		(2)
KIDNEY 		(14)
LIVER 		(1)
LUNG 		(4)
LYMPH 		(26)
OTHER 		(12)
OTHER.mut 		(2)
OVARY 		(2)
PANCREAS 		(2)
PIWI.ip 		(10)
SKIN 		(10)
SPLEEN 		(27)
TESTES 		(4)
THYMUS 		(10)
TOTAL-RNA 		(1)
UTERUS

Sense strand
GACCCGAGAGGGCAATGTCAGGGTCAGCAGAGAGCTGCCTGGCCACACTGGTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGGGTACCTGTCATGCTGCCGCTTCCTGGACGACAACCAAATCATCACCAGC
....................................................................................((((((((((((((((.....))).)))....(((......)))...))))))))))....................................................
.............................................................................78...............................................................143................................................
SizePerfect hitTotal NormPerfect NormSRR546155(SRX180174)
Global profiling of miRNA and the hairpin pre. (ago2 Neuroblastoma)		Ago1IP812(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)		SRR346421(SRX098263)
Global profiling of miRNA and the hairpin pre. (mixture)		Ago1IP517(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)		SRR038742(GSM527277)
small RNA-Seq. (dgcr8 brain)		SRR685339(GSM1079783)
"Small RNAs (15-50 nts in length) from immort. (cell line)		SRR346424(SRX098266)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)		SRR306533(GSM750576)
19-24nt. (ago2 brain)		Ago3IP805(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)		SRR059769(GSM562831)
Treg_Drosha. (spleen)		SRR038744(GSM527279)
small RNA-Seq. (brain)		mjLiverKO1()
Liver Data. (Zcchc11 liver)		mjTestesWT4()
Testes Data. (testes)		SRR553583(SRX182789)
source: Cerebellum. (Cerebellum)		SRR206942(GSM723283)
other. (brain)		SRR306534(GSM750577)
19-24nt. (ago2 brain)		SRR346417(SRX098258)
Global profiling of miRNA and the hairpin pre. (Brain)		SRR206941(GSM723282)
other. (brain)		SRR306540(GSM750583)
19-24nt. (ago2 brain)		SRR346423(SRX098265)
Global profiling of miRNA and the hairpin pre. (Brain)		SRR073954(GSM629280)
total RNA. (blood)		SRR206940(GSM723281)
other. (brain)		SRR038741(GSM527276)
small RNA-Seq. (brain)		Ago3IP812(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)		SRR553602(SRX182808)
source: Sertoli cells. (Sertoli cells)		SRR346414(SRX098255)
Global profiling of miRNA and the hairpin pre. (Spleen)		SRR390300(GSM849858)
cell line: NIH-3T3cell type: fibroblastinfect. (ago2 fibroblast)		SRR306541(GSM750584)
19-24nt. (ago2 brain)		SRR306535(GSM750578)
19-24nt. (ago2 brain)		SRR039610(GSM527274)
small RNA-Seq. (brain)		SRR306542(GSM750585)
19-24nt. (ago2 brain)		SRR390299(GSM849857)
cell line: NIH-3T3cell type: fibroblastip ant. (ago2 fibroblast)		SRR346415(SRX098256)
source: Testis. (Testes)		GSM510456(GSM510456)
newborn_rep12. (total RNA)		SRR391853(GSM852148)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)		SRR391852(GSM852147)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)		SRR306532(GSM750575)
19-24nt. (ago2 brain)		SRR038745(GSM527280)
small RNA-Seq. (dgcr8 brain)		SRR029043(GSM433295)
18.5dpc_homo_tdrd1-KO. (tdrd1 testes)		GSM510444(GSM510444)
brain_rep5. (brain)		SRR391851(GSM852146)
gender: femalegenotype/variation: wild typeti. (embryo)		SRR553582(SRX182788)
source: Brain. (Brain)		SRR346419(SRX098260)
Global profiling of miRNA and the hairpin pre. (Lung)		SRR390297(GSM849855)
cell line: NIH-3T3cell type: fibroblastip ant. (fibroblast)		SRR346425(SRX098267)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)		GSM314557(GSM314557)
ESC dgcr8 (Illumina). (ESC)		SRR038743(GSM527278)
small RNA-Seq. (dicer brain)		SRR206939(GSM723280)
other. (brain)		Ago2IP504(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)		SRR059770(GSM562832)
Treg_Dicer. (spleen)		mjLiverWT3()
Liver Data. (liver)		SRR306536(GSM750579)
19-24nt. (ago2 brain)		SRR402762(SRX117945)
source: ES E14 male cells. (ESC)		SRR248527(GSM733815)
cell type: spermatogonial stem cell enriched . (testes)		SRR346416(SRX098257)
Global profiling of miRNA and the hairpin pre. (Kidney)		SRR391848(GSM852143)
gender: femalegenotype/variation: wild typeti. (embryo)		mjTestesWT3()
Testes Data. (testes)		SRR039185(GSM485325)
shLuc.1309;ROSA-rtTA (-dox). (fibroblast)		SRR306539(GSM750582)
19-24nt. (ago2 brain)		SRR279904(GSM689054)
cell type: mouse embryonic stem cellcell line. (ESC)		SRR029042(GSM433294)
18.5dpc_hetero_tdrd1-KO. (tdrd1 testes)		SRR306537(GSM750580)
19-24nt. (ago2 brain)		SRR037914(GSM510451)
newborn_rep7. (total RNA)		SRR346422(SRX098264)
Global profiling of miRNA and the hairpin pre. (Muscle)		SRR042471(GSM539863)
mouse TFHS cells [09-002]. (spleen)		GSM510453(GSM510453)
newborn_rep9. (total RNA)		SRR042458(GSM539850)
mouse basophil cells [09-002]. (b cell)		SRR248526(GSM733814)
cell type: Thy1- spermatogonial stem cellstra. (testes)		SRR040489(GSM533912)
E18.5 Ago2 catalytically inactive LIVER small RNA. (ago2 liver)		SRR346420(SRX098261)
Global profiling of miRNA and the hairpin pre. (Uterus)		Ago2IP517(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)		SRR391847(GSM852142)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)		SRR029036(GSM433288)
18dpp_hetero_tdrd6-KO. (tdrd6 testes)		SRR042469(GSM539861)
mouse Th2 cells [09-002]. (lymph)		GSM475281(GSM475281)
total RNA. (testes)		SRR042447(GSM539839)
mouse mature B cells (spleen) replicate 2 [09-002]. (b cell)		SRR042459(GSM539851)
mouse neutrophil cells replicate 1 [09-002]. (blood)		SRR042445(GSM539837)
mouse immature B cells [09-002]. (b cell)		mjLiverKO3()
Liver Data. (Zcchc11 liver)		GSM510452(GSM510452)
newborn_rep8. (total RNA)		SRR116846(GSM678422)
Small RNA deep sequencing from mouse epididym. (epididymis)		SRR306544(GSM750587)
19-24nt. (ago2 brain)		SRR391846(GSM852141)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)		SRR279903(GSM689053)
cell type: mouse embryonic stem cellcell line. (ESC)		SRR037924(GSM510462)
e9p5_rep2. (embryo)		SRR306538(GSM750581)
19-24nt. (ago2 brain)		SRR037942(GSM510480)
293DroshaTN_cand5. (cell line)		mjLiverWT1()
Liver Data. (liver)		SRR037925(GSM510463)
e9p5_rep3. (embryo)		GSM519104(GSM519104)
mouse_granulocyte_nuclei_smallRNAs. (cell line)		SRR059765(GSM562827)
DN3_control. (thymus)		SRR037920(GSM510458)
e12p5_rep2. (embryo)		mjTestesWT1()
Testes Data. (testes)		SRR042463(GSM539855)
mouse natural killer cells [09-002]. (spleen)		SRR023847(GSM307156)
mESv6.5smallrna_rep1. (cell line)		SRR037905(GSM510441)
brain_rep2. (brain)		GSM510450(GSM510450)
newborn_rep6. (total RNA)		SRR248523(GSM733811)
cell type: Thy1+ spermatogonial stem cellstra. (testes)		SRR306543(GSM750586)
19-24nt. (ago2 brain)		SRR042456(GSM539848)
mouse hematopoetic progenitor cells [09-002]. (bone marrow)		RuiDGCR8WT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)		SRR037921(GSM510459)
e12p5_rep3. (embryo)		mjTestesWT2()
Testes Data. (testes)		SRR039183(GSM485323)
shLuc.1309 (-dox). (fibroblast)		mjTestesKO6()
Testes Data. (Zcchc11 testes)		SRR029038(GSM433290)
25dpp_hetero_tdrd6-KO. (tdrd6 testes)		mjTestesKO8()
Testes Data. (Zcchc11 testes)		SRR042466(GSM539858)
mouse CD8+ T cells (spleen) [09-002]. (spleen)		GSM314552(GSM314552)
ESC wild type (Illumina). (ESC)		SRR040488(GSM533911)
E18.5 wild type LIVER small RNA. (liver)		SRR059768(GSM562830)
Treg_control. (spleen)		SRR553585(SRX182791)
source: Kidney. (Kidney)		SRR037902(GSM510438)
testes_rep3. (testes)		SRR346418(SRX098259)
Global profiling of miRNA and the hairpin pre. (Liver)		SRR029037(GSM433289)
18dpp_homo_tdrd6-KO. (tdrd6 testes)		SRR391845(GSM852140)
gender: femalegenotype/variation: wild typeti. (embryo)		SRR391849(GSM852144)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)		SRR042448(GSM539840)
mouse B cells activated in vitro with LPS/IL4 replicate 1 [09-002]. (b cell)		SRR095855BC1(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR037909(GSM510446)
newborn_rep2. (total RNA)		SRR042488(GSM539880)
mouse BclXL germinal center B cells [BalbC] [09-002]. (B cell)		SRR059772(GSM562834)
CD4_Drosha. (spleen)		SRR306527(GSM750570)
19-24nt. (ago2 brain)		GSM416732(GSM416732)
MEF. (cell line)		SRR095855BC8(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR029041(GSM433293)
6w_homo_tdrd6-KO. (tdrd6 testes)		SRR042449(GSM539841)
mouse B cells activated in vitro with LPS/IL4 replicate 2 [09-002]. (b cell)		GSM510455(GSM510455)
newborn_rep11. (total RNA)		SRR037912(GSM510449)
newborn_rep5. (total RNA)		SRR042468(GSM539860)
mouse Th1 cells [09-002]. (lymph)		SRR402761(SRX117944)
source: ES E14 male cells. (ESC)		SRR095855BC7(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR073955(GSM629281)
total RNA. (blood)		GSM510454(GSM510454)
newborn_rep10. (total RNA)		SRR059766(GSM562828)
DN3_Drosha. (thymus)		SRR685340(GSM1079784)
"Small RNAs (15-50 nts in length) from immort. (dicer cell line)		SRR037906(GSM510442)
brain_rep3. (brain)		RuiDGCR8KO(Rui)
DGCR8-dependent microRNA biogenesis is essent. (dgcr8 skin)		SRR042455(GSM539847)
mouse plasma cells [09-002]. (blood)		SRR039184(GSM485324)
shLuc.1309 (+dox). (fibroblast)		SRR042467(GSM539859)
mouse T cells activated in vitro with Concanavalin A [09-002]. (spleen)		SRR042477(GSM539869)
mouse brain tissue [09-002]. (brain)		SRR095855BC6(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR279906(GSM689056)
cell type: mouse embryonic stem cellcell line. (ESC)		SRR069834(GSM304914)
Analysis of small RNAs in murine neutrophils cultured in vitro by Solexa/Illumina genome analyzer. (blood)		SRR029123(GSM416611)
NIH3T3. (cell line)		SRR037901(GSM510437)
testes_rep2. (testes)		SRR346413(SRX098254)
Global profiling of miRNA and the hairpin pre. (Heart)		SRR402760(SRX117943)
source: ES E14 male cells. (ESC)		SRR042450(GSM539842)
mouse B cells activated in vitro with LPS/IL4 replicate 3 [09-002]. (b cell)		SRR248525(GSM733813)
cell type: Thy1- spermatogonial stem cellstra. (testes)		SRR065059(SRR065059)
Tissue-specific Regulation of Mouse MicroRNA . (pancreas)		SRR042484(GSM539876)
mouse salivary gland tissue [09-002]. (gland)		SRR059767(GSM562829)
DN3_Dicer. (thymus)		SRR037904(GSM510440)
brain_rep1. (brain)		SRR248524(GSM733812)
cell type: Thy1+ spermatogonial stem cellstra. (testes)		SRR042473(GSM539865)
mouse nTreg cells [09-002]. (lymph)		SRR042462(GSM539854)
mouse macrophages [09-002]. (bone marrow)		SRR042457(GSM539849)
mouse mast cells [09-002]. (bone marrow)		SRR065056(SRR065056)
Tissue-specific Regulation of Mouse MicroRNA . (jejunum)		SRR391850(GSM852145)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)		SRR306528(GSM750571)
19-24nt. (ago2 brain)		SRR394084(GSM855970)
"background strain: C57BL6/SV129cell type: KR. (dicer cell line)		SRR042461(GSM539853)
mouse dendritic cells [09-002]. (bone marrow)		SRR042474(GSM539866)
mouse embryonic stem cells [09-002]. (ESC)		SRR345200(SRX097261)
source: size fractionated RNA from mouse hipp. (brain)		SRR042470(GSM539862)
mouse Th17 cells [09-002]. (lymph)		SRR065054(SRR065054)
Tissue-specific Regulation of Mouse MicroRNA . (jejunum)		SRR095855BC10(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR095855BC3(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR042444(GSM539836)
mouse pre B cells [09-002]. (b cell)		SRR042465(GSM539857)
mouse CD4+ T cells (spleen) [09-002]. (spleen)		SRR042482(GSM539874)
mouse skin tissue [09-002]. (skin)		SRR065049(SRR065049)
Tissue-specific Regulation of Mouse MicroRNA . (liver)		GSM640579(GSM640579)
small RNA in the liver with paternal Low pro. (liver)		SRR553603(SRX182809)
source: Spermatids. (Spermatids)		GSM475280(GSM475280)
Mili-IP. (mili testes)		GSM640580(GSM640580)
small RNA in the liver with paternal Low pro. (liver)		SRR014232(GSM319956)
16.5 dpc MILI. (mili testes)		SRR037907(GSM510443)
brain_rep4. (brain)		SRR065058(SRR065058)
Tissue-specific Regulation of Mouse MicroRNA . (pancreas)		SRR039186(GSM485326)
shLuc.1309;ROSA-rtTA (+dox). (fibroblast)		SRR039154(GSM471931)
HL1_siSrf2_smallRNAseq. (muscle)		SRR039153(GSM471930)
HL1_siSrf1_smallRNAseq. (muscle)		GSM261959(GSM261959)
oocytesmallRNA-19to30. (oocyte)		SRR077865(GSM637802)
18-30 nt small RNAs. (liver)		SRR023851(GSM307160)
ZHBT-c412hsmallrna_rep1. (cell line)		SRR060845(GSM561991)
total RNA. (brain)		SRR042475(GSM539867)
mouse embryonic fibroblast cells [09-002]. (fibroblast)		SRR037910(GSM510447)
newborn_rep3. (total RNA)		mjTestesKO5()
Testes Data. (Zcchc11 testes)		SRR037930(GSM510468)
e7p5_rep4. (embryo)		SRR525244(SRA056111/SRX170320)
Mus musculus domesticus miRNA sequencing. (ago2 Blood)		SRR345197(SRX097258)
source: size fractionated RNA from mouse hipp. (brain)		SRR042454(GSM539846)
mouse germinal center B cells (lymph node) [09-002]. (b cell)		SRR042486(GSM539878)
mouse ovaries [09-002]. (ovary)		RuiDcrWT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)		SRR037929(GSM510467)
e7p5_rep3. (embryo)		SRR037928(GSM510466)
e7p5_rep2. (embryo)		SRR095855BC2(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR023852(GSM307161)
ZHBT-c424hsmallrna_rep1. (cell line)		SRR345203(SRX097264)
source: size fractionated RNA from mouse hipp. (brain)		SRR029039(GSM433291)
25dpp_homo_tdrd6-KO. (tdrd6 testes)		SRR069809(GSM610965)
small RNA sequencing; sample 1. (testes)		SRR042483(GSM539875)
mouse muscle tissue [09-002]. (muscle)		SRR042464(GSM539856)
mouse CD4+CD8+ T cells (thymus) [09-002]. (thymus)		SRR042443(GSM539835)
mouse pro B cells [09-002]. (b cell)		SRR037897(GSM510433)
ovary_rep2. (ovary)		SRR042451(GSM539843)
mouse B cells activated in vitro with LPS/aIgD-Dextran [09-002]. (b cell)		GSM640581(GSM640581)
small RNA in the liver with paternal control. (liver)		SRR077864(GSM637801)
18-30 nt small RNAs. (liver)		SRR023849(GSM307158)
NPCsmallrna_rep1. (cell line)		GSM509279(GSM509279)
MVH-/- E16.5 small RNA. (testes)		SRR077866(GSM637803)
18-30 nt small RNAs. (liver)		SRR345204(SRX097265)
source: size fractionated RNA from mouse hipp. (brain)		SRR394083(GSM855969)
"background strain: C57BL6/SV129cell type: KR. (cell line)
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGT.................................................2211481.00153.00220.0037.00-33.0043.0044.0036.0045.0016.0026.0029.0026.0010.0025.0024.0022.0020.0027.0030.0017.0020.0022.0019.0015.0018.0015.0016.0020.0021.0015.0014.009.0014.005.0010.0011.0016.0015.0018.0012.0010.0014.0011.0011.0012.0012.0011.0010.005.0010.006.0012.004.009.0011.008.005.008.009.008.006.0010.003.005.005.001.002.005.006.009.003.001.004.001.004.004.003.005.006.002.003.005.002.00--5.00-5.00-1.005.003.005.002.00-2.001.003.003.002.004.003.001.002.002.001.002.002.004.003.003.002.004.002.003.002.003.00-2.001.001.00-2.003.003.003.00--1.00-3.003.00-3.001.00-2.002.00-2.002.001.002.002.002.00-2.001.002.00-1.001.001.001.002.00--1.001.002.001.002.00-2.001.00-1.00---1.001.00-1.00-1.001.00--1.00-1.00-1.001.00-1.00-1.00-1.00-1.00--1.001.001.001.001.001.00-1.00-1.00----1.00------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAG..................................................211153.00153.0027.007.00-3.002.001.004.00-2.004.005.0012.0014.004.002.006.004.00--5.001.001.001.00-1.005.00---2.002.00--2.00-1.001.00--1.00-1.001.00----1.00-1.001.00-1.002.00-1.00------1.001.001.001.00----1.00-2.00--1.00----1.00----1.00-------1.00-1.00------1.00--------2.00-----1.00--------------1.00------------------1.001.00----1.00----------------1.00-----1.00------1.00--------------------------1.00-
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGA.................................................221147.00153.0013.00---2.004.002.00---1.00-7.003.00--4.001.00-1.002.001.00-1.003.001.009.00----9.00-3.009.005.00---2.004.00--5.001.00--1.00--7.00-6.00-1.001.002.00--1.00--3.001.00-5.00-2.00----------1.001.001.00---1.00---1.001.00-1.00-1.00-1.001.00----1.00--2.00-------------1.00-------------2.00-1.00--------------1.001.00----1.00-------------1.00---------------------------------1.00------1.001.00----
...........................................................................................................................CTGCAACCTCCTTTCTCCAGT.................................................211143.006.0011.0010.00-12.002.00-1.002.0016.004.003.00---4.004.00-1.00-1.001.002.003.006.001.00--3.003.001.004.00--1.00--3.00----1.00--3.002.00--7.00--2.001.00----2.002.00-1.00-------3.00-3.002.00----1.00----1.00-4.00-----1.00-------------1.00------1.00--------1.00-1.001.00-------------1.00-------------------1.00-----------1.00-----------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAG..................................................93146.0046.00--46.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCA...................................................20144.0044.008.00---3.00---1.00----1.004.00-2.00--1.00------------3.002.00---1.00---1.001.00---1.00-1.001.00----------1.00-----1.00---1.001.00--1.00-----1.00-------------3.00-2.00---------1.00----------------------------------------1.00--------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGTT................................................22125.006.006.006.00-3.00----3.00-1.00-----------1.002.001.00-----1.00----------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................TGCAACCTCCTTTCTCCAGT.................................................2018.000.00---1.00------------------1.00----------2.00----------------------------2.00--1.00-------------2.00----4.00---3.00------------------------------1.00--------1.00---------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGC.................................................22118.00153.003.00----3.004.00----------1.00-1.00-------------1.00-----1.00-----------------------1.00---------------------------------------------------------------1.00--------------------------------1.00----------------------------1.00--------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCC....................................................19118.0018.002.001.00--4.00-----1.00-----1.00--1.00-----1.00-------------1.00------1.00-1.00------1.00-----------1.00------1.00----------------------------------------------------------------------------------------------------------------------------------1.00----------
..........................................................................................................................ACTGCAACCTCCTTTCTCCATT.................................................22112.0044.001.001.00--2.00--------1.00------1.00---1.00----------------1.00-----1.00-1.00------------------------1.001.00--------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTT................................................2317.00153.001.001.00-----------------------1.00-----------1.00----------------1.001.00---------------------------------------------------1.00------------------------------------------------------------------------------------------------------------
.......................................................................................................................CTGACTGCAACCTCCTTTCTCCAG..................................................2417.007.00------------5.00--------------------2.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACT........................................................................................2317.007.00--------1.00---------------------------------------------------------2.00------2.00----------------------------------------------------1.00-----------1.00-----------------------------------------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCACTGT......................................................................................2417.007.00------3.00----------------------------------------------------------------------1.00---------------------------------------1.00------------------------------------------------------------1.00---------------------------1.00---------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCA...................................................9216.006.00--6.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAG..................................................2016.006.002.001.00---------------------------1.00---------------------------------------------1.00--------------------------1.00-----------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTA................................................2316.00153.001.00--1.00-1.00-------------1.00------------1.00--------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCCGT.................................................2216.0018.00-------------1.00------3.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAT..................................................2115.0044.002.00------------------------------------1.00---------1.00-------------------------------------------1.00----------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGC.................................................2115.006.00---------------------------------2.00-------------------------------1.00-------------------------------------------------------------1.001.00---------------------------------------------------------------------------------------
.......................................................................................................................CTGACTGCAACCTCCGACA.......................................................195.000.00--------------------------------------------------------------------------------------5.00---------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGTA................................................2215.006.00---1.00-------------1.00---------------1.00----------------------------1.00------------------------------------------1.00--------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCATA.................................................2214.0044.00-1.00---------------------------1.00---------------------------------1.00-----------------------------------------------------------------------------1.00--------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGG.................................................2214.004.001.00--1.00-----------------------1.00-----------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCAC.........................................................................................2314.004.00---------3.00------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00-------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCACTG.......................................................................................2313.003.00---------1.00---------------------------------------------------------------1.00-------------------------------------------------------1.00--------------------------------------------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGA.................................................9413.0046.00--3.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCACTGTC.....................................................................................2513.003.00------------------------------------------------------------------1.00----------------------------------------1.00----------------------------------------------------------------------------------------------------1.00-------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGTTA...............................................2313.006.002.00--------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTGT......................................................................................2513.003.00-------------------------------------------------1.00-----------------1.00-------------------------------------------------------------1.00--------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCACTG.......................................................................................2513.003.00-----------------------------------------------------------------------------------2.00---------1.00--------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGA.................................................2113.006.001.00---------------1.00-----------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------
............................................................................................................................TGCAACCTCCTTTCTCCAGTAGA..............................................233.000.00-------------------------------3.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTC.....................................................1813.003.00-------------------------1.00---1.00-----------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCAAGT.................................................2213.003.00-----1.00----------------------------------------------------------------------1.00---------------------1.00---------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGAA................................................2313.00153.00-----------------------------------------------------------------------------1.00-------------------------------------------------------------------2.00----------------------------------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCACT........................................................................................2213.003.00----------------------------------------------------------------2.00--------1.00----------------------------------------------------------------------------------------------------------------------------------------------
........................................................................................................................TGACTGCAACCTCCTTTCTCCAGA.................................................2413.002.00--------------------------------------------------------3.00---------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCATT.................................................213.000.00---1.00------------------------------------------------------------------1.00---------------------------------------------------------------------------------------1.00---------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGTTT...............................................643.000.00--3.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................................GCAACCTCCTTTCTCCAGT.................................................193.000.00---------------1.00-----------------------------------------1.00---------------------------------------------1.00----------------------------------------------------------------------------------------------------------------
............................................................................................................................TGCAACCTCCTTTCTCCAGTT................................................213.000.00-1.00------------------------------------------------------------------------1.00----------------------------------------------1.00----------------------------------------------------------------------------------------------
.......................................................................................................................CTGACTGCAACCTCCTTTCTCCAGA.................................................2512.007.00------1.00------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTAAA..............................................2512.00153.00----------------------------------------------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------
...........................................................................................................................CTGCAACCTCCTTTCTCCAT..................................................202.000.001.00----------------------------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCA..........................................................................................2212.002.00------------------------------------------------------------------1.00------1.00----------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGTTT...............................................2312.006.002.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAA..................................................2112.0044.001.00----------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------
....CGAGAGGGCAATGTCAGGGTCAG......................................................................................................................................................................2312.002.00------1.00--------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................CCTGGACGACAACCAAATCATC......2212.002.00-----------------------------------------------------------------------1.00-------------------------------------------1.00----------------------------------------------------------------------------------------------------
........................................................................................................................................................................GGACGACAACCAAATCATC......1912.002.00----------------------------------------------------------------------------------2.00-------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................CCTGGACGACAACCAAATC.........1912.002.00----------------------------------------------1.00--------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCTAGT.................................................2212.003.00------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------------1.00------------------------------
.......................................................................................................................................................TCATGCTGCCGCTTCCTGGACG....................2212.002.00---------------------------------------------------------------------------------------------------------------------------------------2.00--------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTAA...............................................2412.00153.001.00-----------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCACT........................................................................................2412.002.00------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------1.00---
........................................................................................................................TGACTGCAACCTCCTTTCTCCAG..................................................2312.002.00------------------------1.00--------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------
................GTCAGGGTCAGCAGAGAGCT.............................................................................................................................................................2012.002.00-----------------------------------------------------------------------1.00----------1.00-------------------------------------------------------------------------------------------------------------------------------------
................GTCAGGGTCAGCAGAGAG...............................................................................................................................................................1812.002.00----------------------------------------------------------------------------------------------2.00-------------------------------------------------------------------------------------------------------------------------
................GTCAGGGTCAGCAGAGAGCTGCCTGGCC.....................................................................................................................................................2812.002.00------------------------------------------------------------------------------------1.00---1.00-------------------------------------------------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCACTGT......................................................................................2612.002.00------------------------------------------------------------------------------------------------------------------------------------------------------------------2.00-----------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCATTT................................................222.000.00-1.00------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGATT...............................................2312.006.00----------------------1.00-------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGAT................................................2211.006.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTC................................................2311.00153.00---1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCT......................................................8911.001.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................TCAGGGTCAGCAGAGAGCTGCC..........................................................................................................................................................2211.001.00-----------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................................................................TGCCGCTTCCTGGACGACA.................1911.001.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00--
.....................................................AGTGGAGCCAGAAGAGGCAAGAACACGGT...............................................................................................................2911.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------1.00------------------------------------------------------------
....................................................................................................................................................................TCCTGGACGACAACCAAATCATCACC...2611.001.00-----------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCC....................................................9111.001.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAA..................................................201.000.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................................................................AGGGAAGAGATGCACTGTCCTC..................................................................................2211.001.00------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................................................................ACGACAACCAAATCATCACCAGC2311.001.00----------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................CCTGTCATGCTGCCGCTTC...........................1911.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------1.00------------------------------------------------------------------
........................................................................................................................................................................GGACGACAACCAAATCATCACC...2211.001.00----------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTAT...............................................2411.00153.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................AGGGTCAGCAGAGAGCTGC...........................................................................................................................................................1911.001.00-----------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................GCTGCCTGGCCACACTGGG.............................................................................................................................................191.000.00----------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................................TGGACGACAACCAAATCATCACCAGC2611.001.00------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCAATAG......................................................................................2611.002.00---------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------
...................................................TGAGTGGAGCCAGAAGAGGCAAGAACA...................................................................................................................2711.001.00-------------------------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCATTT................................................2311.0044.00-----------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCCGC.................................................2211.0018.00---------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
........AGGGCAATGTCAGGGTCAG......................................................................................................................................................................1911.001.00----------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACAGT......................................................................................2511.001.00------------------------------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------
....................................................................................................................................................................TCCTGGACGACAACCAAATC.........2011.001.00-----------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................AGAGAGCTGCCTGGCCAC...................................................................................................................................................1811.001.00-------------------------------------------------------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACAC..................................................................................................................2911.001.00------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTG.......................................................................................2411.001.00-------------------------------------------------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCA..........................................................................................2111.001.00------------------------------------------------------------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------
................................................................................................................................................................CGCTTCCTGGACGACAACCAAAT..........2311.001.00-----------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCACT.................................................2211.0044.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCAC.........................................................................................2111.001.00---------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAA..................................................9311.006.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTGTC.....................................................................................2611.001.00----------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTGTCC....................................................................................2711.001.00---------------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------
...................................................................................................................................................CCTGTCATGCTGCCGCTTCCTGGACGAC..................2811.001.00-----------------------------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCCGA.................................................2211.0018.00--------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................GGGTACCTGTCATGCTGCCGCTTCCTG........................2711.001.00------------------------------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------
................................................................................GTCAGGGGAAGGGAAGAGATGCAA.........................................................................................241.000.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00------------------------
........................................................................................................................................................CATGCTGCCGCTTCCTGGACGAC..................2311.001.00------------------------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------
...............................................................................................................................AACCTCCTTTCTCCAGT.................................................171.000.00---------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGAGA...............................................2411.00153.00------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCT...................................................2011.0018.00----------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGC...........................................................................................2111.001.00---------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAG.......................................................................................................................2411.001.00----------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
........AGGGCAATGTCAGGGTCAGCAGAG.................................................................................................................................................................2411.001.00----------------------------------------------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTAG...............................................2411.00153.00-----------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCATAA................................................2311.0044.00-------------------------1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCAC.........................................................................................2211.001.00-------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAGTGA...............................................2411.00153.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................GCTTCCTGGACGACAACCAAA...........2111.001.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................ACCTGTCATGCTGCCGCTTC...........................2011.001.00---------------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------
..........................................................................................................................ACTGCAACCTCCTTTCTCCAAT.................................................2211.0044.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
........................................................................................................................................................................GGACGACAACCAAATGCTC......191.000.00----------------------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------
......AGAGGGCAATGTCAGGGTCAGCAGAGAG...............................................................................................................................................................2811.001.00------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................CTGACTGCAACCTCCTTTCTCCAGAA................................................2611.007.00--------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.........................................GCCACACTGGTGAGTGT.......................................................................................................................................171.000.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00----------------------
.........................AGCAGAGAGCTGCCTGGCCAC...................................................................................................................................................2111.001.00------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCACTGTTT....................................................................................2611.007.00------------------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGTAG...............................................2311.006.00---------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................CCTGACTGCAACCTCCTTTCTCCAG..................................................2511.001.00--------------------------------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................CAGAGAGCTGCCTGGCC.....................................................................................................................................................1731.001.00--------------------------------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................AGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGA.................................................791.000.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGC...........................................................................................2011.001.00-1.00----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................TCAGGGGAAGGGAAGAGATGCACTGTC.....................................................................................2711.001.00---------------------------------------------------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................GGTACCTGTCATGCTGCC................................1811.001.00------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................................CTTCCTGGACGACAA................1511.001.00-----------------------------------------------------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGAC................................................2211.006.00---1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGA.................................................931.000.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................GGGAAGGGAAGAGATGCACTGTCT....................................................................................241.000.00---------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................TCTAAAATGCCTGACTGCAACCTC............................................................2411.001.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------
......................................................................................................................................................................CTGGACGACAACCAAATCATCA.....2211.001.00------------------------------------------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------------------
.................................................................................................................................................................GCTTCCTGGACGACAACCA.............1911.001.00-----------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------
................................................................................GTCAGGGGAAGGGAAGAGATGCAT.........................................................................................241.000.00-----------------------------------------------------------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------
....................................................................................................................................................................TCCTGGACGACAACCAAATCA........2111.001.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00---------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGTAT...............................................2311.006.00----------------------------------------------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................GCTTCCTGGACGACAACCAAATCATCACCAGC3211.001.00--------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
........................................................................................................................TGACTGCAACCTCCTTTCTCCAGAA................................................2511.002.00----------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................GTCATGCTGCCGCTTCCTGGAC.....................2211.001.00----------------------------------------1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................CTGCAACCTCCTTTCTCCAGAA................................................2211.006.00---1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................GCTTCCTGGACGACAACCAAATCA........2411.001.00-------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................GCTTCCTGGACGACAACCAA............2011.001.00-------------------------------------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------
...................................................................................AGGGGAAGGGAAGAGATGCAA.........................................................................................211.000.00--------------------------------------------------------------------------------------------------------------------------------------1.00---------------------------------------------------------------------------------
..............................................................................................................................CAACCTCCTTTCTCCAGT.................................................181.000.00------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGT.................................................621.000.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.......GAGGGCAATGTCAGGGTCAGC.....................................................................................................................................................................2111.001.00-------------------------------------------------------------------------------1.00----------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................GCCGCTTCCTGGACGACAACCAA............2311.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00------------------------------------------------
..................................................GTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTA................................................................................6311.001.00--1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
...................AGGGTCAGCAGAGAGCTGCCTGGC......................................................................................................................................................2411.001.00--------------------------------1.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................TCATGCTGCCGCTTCCTGGACGA...................2311.001.00-----------------------1.00------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGATGCACTGG......................................................................................2511.001.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00---------------------------------------------------
....................................................................GGCAAGAACACGGTCAGGGGAAG......................................................................................................2311.001.00----1.00-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
..................CAGGGTCAGCAGAGAGCT.............................................................................................................................................................1820.500.50----------------------------------0.50-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.............AATGTCAGGGTCAGCAG...................................................................................................................................................................1720.500.50------------------------------------------0.50-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
.............................GAGAGCTGCCTGGCCAC...................................................................................................................................................1730.330.33-------------------------------------0.33----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
............................AGAGAGCTGCCTGGCC.....................................................................................................................................................1670.140.14-----------------------------------------------------------------------------------------------------------------0.14------------------------------------------------------------------------------------------------------
..............................................................................................AGAGATGCACTGTCC....................................................................................1590.110.11---------------------------------------------------------------------------------------------------------------------------------------------------------------------0.11--------------------------------------------------

Antisense strand
GACCCGAGAGGGCAATGTCAGGGTCAGCAGAGAGCTGCCTGGCCACACTGGTGAGTGGAGCCAGAAGAGGCAAGAACACGGTCAGGGGAAGGGAAGAGATGCACTGTCCTCTAAAATGCCTGACTGCAACCTCCTTTCTCCAGGGTACCTGTCATGCTGCCGCTTCCTGGACGACAACCAAATCATCACCAGC
....................................................................................((((((((((((((((.....))).)))....(((......)))...))))))))))....................................................
.............................................................................78...............................................................143................................................
SizePerfect hitTotal NormPerfect NormSRR546155(SRX180174)
Global profiling of miRNA and the hairpin pre. (ago2 Neuroblastoma)		Ago1IP812(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)		SRR346421(SRX098263)
Global profiling of miRNA and the hairpin pre. (mixture)		Ago1IP517(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)		SRR038742(GSM527277)
small RNA-Seq. (dgcr8 brain)		SRR685339(GSM1079783)
"Small RNAs (15-50 nts in length) from immort. (cell line)		SRR346424(SRX098266)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)		SRR306533(GSM750576)
19-24nt. (ago2 brain)		Ago3IP805(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)		SRR059769(GSM562831)
Treg_Drosha. (spleen)		SRR038744(GSM527279)
small RNA-Seq. (brain)		mjLiverKO1()
Liver Data. (Zcchc11 liver)		mjTestesWT4()
Testes Data. (testes)		SRR553583(SRX182789)
source: Cerebellum. (Cerebellum)		SRR206942(GSM723283)
other. (brain)		SRR306534(GSM750577)
19-24nt. (ago2 brain)		SRR346417(SRX098258)
Global profiling of miRNA and the hairpin pre. (Brain)		SRR206941(GSM723282)
other. (brain)		SRR306540(GSM750583)
19-24nt. (ago2 brain)		SRR346423(SRX098265)
Global profiling of miRNA and the hairpin pre. (Brain)		SRR073954(GSM629280)
total RNA. (blood)		SRR206940(GSM723281)
other. (brain)		SRR038741(GSM527276)
small RNA-Seq. (brain)		Ago3IP812(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)		SRR553602(SRX182808)
source: Sertoli cells. (Sertoli cells)		SRR346414(SRX098255)
Global profiling of miRNA and the hairpin pre. (Spleen)		SRR390300(GSM849858)
cell line: NIH-3T3cell type: fibroblastinfect. (ago2 fibroblast)		SRR306541(GSM750584)
19-24nt. (ago2 brain)		SRR306535(GSM750578)
19-24nt. (ago2 brain)		SRR039610(GSM527274)
small RNA-Seq. (brain)		SRR306542(GSM750585)
19-24nt. (ago2 brain)		SRR390299(GSM849857)
cell line: NIH-3T3cell type: fibroblastip ant. (ago2 fibroblast)		SRR346415(SRX098256)
source: Testis. (Testes)		GSM510456(GSM510456)
newborn_rep12. (total RNA)		SRR391853(GSM852148)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)		SRR391852(GSM852147)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)		SRR306532(GSM750575)
19-24nt. (ago2 brain)		SRR038745(GSM527280)
small RNA-Seq. (dgcr8 brain)		SRR029043(GSM433295)
18.5dpc_homo_tdrd1-KO. (tdrd1 testes)		GSM510444(GSM510444)
brain_rep5. (brain)		SRR391851(GSM852146)
gender: femalegenotype/variation: wild typeti. (embryo)		SRR553582(SRX182788)
source: Brain. (Brain)		SRR346419(SRX098260)
Global profiling of miRNA and the hairpin pre. (Lung)		SRR390297(GSM849855)
cell line: NIH-3T3cell type: fibroblastip ant. (fibroblast)		SRR346425(SRX098267)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)		GSM314557(GSM314557)
ESC dgcr8 (Illumina). (ESC)		SRR038743(GSM527278)
small RNA-Seq. (dicer brain)		SRR206939(GSM723280)
other. (brain)		Ago2IP504(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)		SRR059770(GSM562832)
Treg_Dicer. (spleen)		mjLiverWT3()
Liver Data. (liver)		SRR306536(GSM750579)
19-24nt. (ago2 brain)		SRR402762(SRX117945)
source: ES E14 male cells. (ESC)		SRR248527(GSM733815)
cell type: spermatogonial stem cell enriched . (testes)		SRR346416(SRX098257)
Global profiling of miRNA and the hairpin pre. (Kidney)		SRR391848(GSM852143)
gender: femalegenotype/variation: wild typeti. (embryo)		mjTestesWT3()
Testes Data. (testes)		SRR039185(GSM485325)
shLuc.1309;ROSA-rtTA (-dox). (fibroblast)		SRR306539(GSM750582)
19-24nt. (ago2 brain)		SRR279904(GSM689054)
cell type: mouse embryonic stem cellcell line. (ESC)		SRR029042(GSM433294)
18.5dpc_hetero_tdrd1-KO. (tdrd1 testes)		SRR306537(GSM750580)
19-24nt. (ago2 brain)		SRR037914(GSM510451)
newborn_rep7. (total RNA)		SRR346422(SRX098264)
Global profiling of miRNA and the hairpin pre. (Muscle)		SRR042471(GSM539863)
mouse TFHS cells [09-002]. (spleen)		GSM510453(GSM510453)
newborn_rep9. (total RNA)		SRR042458(GSM539850)
mouse basophil cells [09-002]. (b cell)		SRR248526(GSM733814)
cell type: Thy1- spermatogonial stem cellstra. (testes)		SRR040489(GSM533912)
E18.5 Ago2 catalytically inactive LIVER small RNA. (ago2 liver)		SRR346420(SRX098261)
Global profiling of miRNA and the hairpin pre. (Uterus)		Ago2IP517(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)		SRR391847(GSM852142)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)		SRR029036(GSM433288)
18dpp_hetero_tdrd6-KO. (tdrd6 testes)		SRR042469(GSM539861)
mouse Th2 cells [09-002]. (lymph)		GSM475281(GSM475281)
total RNA. (testes)		SRR042447(GSM539839)
mouse mature B cells (spleen) replicate 2 [09-002]. (b cell)		SRR042459(GSM539851)
mouse neutrophil cells replicate 1 [09-002]. (blood)		SRR042445(GSM539837)
mouse immature B cells [09-002]. (b cell)		mjLiverKO3()
Liver Data. (Zcchc11 liver)		GSM510452(GSM510452)
newborn_rep8. (total RNA)		SRR116846(GSM678422)
Small RNA deep sequencing from mouse epididym. (epididymis)		SRR306544(GSM750587)
19-24nt. (ago2 brain)		SRR391846(GSM852141)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)		SRR279903(GSM689053)
cell type: mouse embryonic stem cellcell line. (ESC)		SRR037924(GSM510462)
e9p5_rep2. (embryo)		SRR306538(GSM750581)
19-24nt. (ago2 brain)		SRR037942(GSM510480)
293DroshaTN_cand5. (cell line)		mjLiverWT1()
Liver Data. (liver)		SRR037925(GSM510463)
e9p5_rep3. (embryo)		GSM519104(GSM519104)
mouse_granulocyte_nuclei_smallRNAs. (cell line)		SRR059765(GSM562827)
DN3_control. (thymus)		SRR037920(GSM510458)
e12p5_rep2. (embryo)		mjTestesWT1()
Testes Data. (testes)		SRR042463(GSM539855)
mouse natural killer cells [09-002]. (spleen)		SRR023847(GSM307156)
mESv6.5smallrna_rep1. (cell line)		SRR037905(GSM510441)
brain_rep2. (brain)		GSM510450(GSM510450)
newborn_rep6. (total RNA)		SRR248523(GSM733811)
cell type: Thy1+ spermatogonial stem cellstra. (testes)		SRR306543(GSM750586)
19-24nt. (ago2 brain)		SRR042456(GSM539848)
mouse hematopoetic progenitor cells [09-002]. (bone marrow)		RuiDGCR8WT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)		SRR037921(GSM510459)
e12p5_rep3. (embryo)		mjTestesWT2()
Testes Data. (testes)		SRR039183(GSM485323)
shLuc.1309 (-dox). (fibroblast)		mjTestesKO6()
Testes Data. (Zcchc11 testes)		SRR029038(GSM433290)
25dpp_hetero_tdrd6-KO. (tdrd6 testes)		mjTestesKO8()
Testes Data. (Zcchc11 testes)		SRR042466(GSM539858)
mouse CD8+ T cells (spleen) [09-002]. (spleen)		GSM314552(GSM314552)
ESC wild type (Illumina). (ESC)		SRR040488(GSM533911)
E18.5 wild type LIVER small RNA. (liver)		SRR059768(GSM562830)
Treg_control. (spleen)		SRR553585(SRX182791)
source: Kidney. (Kidney)		SRR037902(GSM510438)
testes_rep3. (testes)		SRR346418(SRX098259)
Global profiling of miRNA and the hairpin pre. (Liver)		SRR029037(GSM433289)
18dpp_homo_tdrd6-KO. (tdrd6 testes)		SRR391845(GSM852140)
gender: femalegenotype/variation: wild typeti. (embryo)		SRR391849(GSM852144)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)		SRR042448(GSM539840)
mouse B cells activated in vitro with LPS/IL4 replicate 1 [09-002]. (b cell)		SRR095855BC1(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR037909(GSM510446)
newborn_rep2. (total RNA)		SRR042488(GSM539880)
mouse BclXL germinal center B cells [BalbC] [09-002]. (B cell)		SRR059772(GSM562834)
CD4_Drosha. (spleen)		SRR306527(GSM750570)
19-24nt. (ago2 brain)		GSM416732(GSM416732)
MEF. (cell line)		SRR095855BC8(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR029041(GSM433293)
6w_homo_tdrd6-KO. (tdrd6 testes)		SRR042449(GSM539841)
mouse B cells activated in vitro with LPS/IL4 replicate 2 [09-002]. (b cell)		GSM510455(GSM510455)
newborn_rep11. (total RNA)		SRR037912(GSM510449)
newborn_rep5. (total RNA)		SRR042468(GSM539860)
mouse Th1 cells [09-002]. (lymph)		SRR402761(SRX117944)
source: ES E14 male cells. (ESC)		SRR095855BC7(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR073955(GSM629281)
total RNA. (blood)		GSM510454(GSM510454)
newborn_rep10. (total RNA)		SRR059766(GSM562828)
DN3_Drosha. (thymus)		SRR685340(GSM1079784)
"Small RNAs (15-50 nts in length) from immort. (dicer cell line)		SRR037906(GSM510442)
brain_rep3. (brain)		RuiDGCR8KO(Rui)
DGCR8-dependent microRNA biogenesis is essent. (dgcr8 skin)		SRR042455(GSM539847)
mouse plasma cells [09-002]. (blood)		SRR039184(GSM485324)
shLuc.1309 (+dox). (fibroblast)		SRR042467(GSM539859)
mouse T cells activated in vitro with Concanavalin A [09-002]. (spleen)		SRR042477(GSM539869)
mouse brain tissue [09-002]. (brain)		SRR095855BC6(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR279906(GSM689056)
cell type: mouse embryonic stem cellcell line. (ESC)		SRR069834(GSM304914)
Analysis of small RNAs in murine neutrophils cultured in vitro by Solexa/Illumina genome analyzer. (blood)		SRR029123(GSM416611)
NIH3T3. (cell line)		SRR037901(GSM510437)
testes_rep2. (testes)		SRR346413(SRX098254)
Global profiling of miRNA and the hairpin pre. (Heart)		SRR402760(SRX117943)
source: ES E14 male cells. (ESC)		SRR042450(GSM539842)
mouse B cells activated in vitro with LPS/IL4 replicate 3 [09-002]. (b cell)		SRR248525(GSM733813)
cell type: Thy1- spermatogonial stem cellstra. (testes)		SRR065059(SRR065059)
Tissue-specific Regulation of Mouse MicroRNA . (pancreas)		SRR042484(GSM539876)
mouse salivary gland tissue [09-002]. (gland)		SRR059767(GSM562829)
DN3_Dicer. (thymus)		SRR037904(GSM510440)
brain_rep1. (brain)		SRR248524(GSM733812)
cell type: Thy1+ spermatogonial stem cellstra. (testes)		SRR042473(GSM539865)
mouse nTreg cells [09-002]. (lymph)		SRR042462(GSM539854)
mouse macrophages [09-002]. (bone marrow)		SRR042457(GSM539849)
mouse mast cells [09-002]. (bone marrow)		SRR065056(SRR065056)
Tissue-specific Regulation of Mouse MicroRNA . (jejunum)		SRR391850(GSM852145)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)		SRR306528(GSM750571)
19-24nt. (ago2 brain)		SRR394084(GSM855970)
"background strain: C57BL6/SV129cell type: KR. (dicer cell line)		SRR042461(GSM539853)
mouse dendritic cells [09-002]. (bone marrow)		SRR042474(GSM539866)
mouse embryonic stem cells [09-002]. (ESC)		SRR345200(SRX097261)
source: size fractionated RNA from mouse hipp. (brain)		SRR042470(GSM539862)
mouse Th17 cells [09-002]. (lymph)		SRR065054(SRR065054)
Tissue-specific Regulation of Mouse MicroRNA . (jejunum)		SRR095855BC10(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR095855BC3(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR042444(GSM539836)
mouse pre B cells [09-002]. (b cell)		SRR042465(GSM539857)
mouse CD4+ T cells (spleen) [09-002]. (spleen)		SRR042482(GSM539874)
mouse skin tissue [09-002]. (skin)		SRR065049(SRR065049)
Tissue-specific Regulation of Mouse MicroRNA . (liver)		GSM640579(GSM640579)
small RNA in the liver with paternal Low pro. (liver)		SRR553603(SRX182809)
source: Spermatids. (Spermatids)		GSM475280(GSM475280)
Mili-IP. (mili testes)		GSM640580(GSM640580)
small RNA in the liver with paternal Low pro. (liver)		SRR014232(GSM319956)
16.5 dpc MILI. (mili testes)		SRR037907(GSM510443)
brain_rep4. (brain)		SRR065058(SRR065058)
Tissue-specific Regulation of Mouse MicroRNA . (pancreas)		SRR039186(GSM485326)
shLuc.1309;ROSA-rtTA (+dox). (fibroblast)		SRR039154(GSM471931)
HL1_siSrf2_smallRNAseq. (muscle)		SRR039153(GSM471930)
HL1_siSrf1_smallRNAseq. (muscle)		GSM261959(GSM261959)
oocytesmallRNA-19to30. (oocyte)		SRR077865(GSM637802)
18-30 nt small RNAs. (liver)		SRR023851(GSM307160)
ZHBT-c412hsmallrna_rep1. (cell line)		SRR060845(GSM561991)
total RNA. (brain)		SRR042475(GSM539867)
mouse embryonic fibroblast cells [09-002]. (fibroblast)		SRR037910(GSM510447)
newborn_rep3. (total RNA)		mjTestesKO5()
Testes Data. (Zcchc11 testes)		SRR037930(GSM510468)
e7p5_rep4. (embryo)		SRR525244(SRA056111/SRX170320)
Mus musculus domesticus miRNA sequencing. (ago2 Blood)		SRR345197(SRX097258)
source: size fractionated RNA from mouse hipp. (brain)		SRR042454(GSM539846)
mouse germinal center B cells (lymph node) [09-002]. (b cell)		SRR042486(GSM539878)
mouse ovaries [09-002]. (ovary)		RuiDcrWT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)		SRR037929(GSM510467)
e7p5_rep3. (embryo)		SRR037928(GSM510466)
e7p5_rep2. (embryo)		SRR095855BC2(SRX039178)
sequencing of miRNA from wild type and diseas. (heart)		SRR023852(GSM307161)
ZHBT-c424hsmallrna_rep1. (cell line)		SRR345203(SRX097264)
source: size fractionated RNA from mouse hipp. (brain)		SRR029039(GSM433291)
25dpp_homo_tdrd6-KO. (tdrd6 testes)		SRR069809(GSM610965)
small RNA sequencing; sample 1. (testes)		SRR042483(GSM539875)
mouse muscle tissue [09-002]. (muscle)		SRR042464(GSM539856)
mouse CD4+CD8+ T cells (thymus) [09-002]. (thymus)		SRR042443(GSM539835)
mouse pro B cells [09-002]. (b cell)		SRR037897(GSM510433)
ovary_rep2. (ovary)		SRR042451(GSM539843)
mouse B cells activated in vitro with LPS/aIgD-Dextran [09-002]. (b cell)		GSM640581(GSM640581)
small RNA in the liver with paternal control. (liver)		SRR077864(GSM637801)
18-30 nt small RNAs. (liver)		SRR023849(GSM307158)
NPCsmallrna_rep1. (cell line)		GSM509279(GSM509279)
MVH-/- E16.5 small RNA. (testes)		SRR077866(GSM637803)
18-30 nt small RNAs. (liver)		SRR345204(SRX097265)
source: size fractionated RNA from mouse hipp. (brain)		SRR394083(GSM855969)
"background strain: C57BL6/SV129cell type: KR. (cell line)
......................................................................................................ACTGTCCTCTAAAATCTC......................................................................... 181.000.00--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00---------------------------------
.........................AGCAGAGAGCTGCCTCCCG..................................................................................................................................................... 191.000.00---------------------------------------------------------------------------------------------------------------------------------------------------------------------1.00--------------------------------------------------
.............................................................................................................................GCAACCTCCTTTCTCCAGGG................................................ 2011.001.00---------------------------------------------------------1.00--------------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................................................CAGGGGAAGGGAAGAGA.............................................................................................. 1780.250.25-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------0.25