hsa-let-7a-1 chr9:95978040-95978159 + UCUUCACUGUGGGAUGAGGUAGUAGGUUGUAUAGUUUUAGGGUCACACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUUUCCUAACGUGAUAGA (((((((..(((((.(((..((((((((((((((((...(((.....))).((....))....))))))))))))))))..))))))))..)))).))) (-42.10) ..............UGAGGUAGUAGGUUGUAUAGUU............................................................... 30 3 hsa-let-7a-1_L01_M J1_ES_demeth ..............UGAGGUAGUAGGUUGUAUAGUU............................................................... 3 3 hsa-let-7a-1_L02 J1_ES_untr ..............UGAGGUAGUAGGUUGUAUAGUUU.............................................................. 1 3 hsa-let-7a-1_L03 J1_ES_demeth ....................................UUAGGGUCACACCCACCACUGGGAGAUAA.................................. 1 1 hsa-let-7a-1_O01 J1_ES_demeth hsa-let-7a-2 chr11:121522420-121522531 - GCAUGCUCCCAGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCUUGGGUCUUG .......((((((..(((.(((.(((((((((((((.....(..(.....)..)...))))))))))))).))).)))..))))))..... (-34.40) ..............UGAGGUAGUAGGUUGUAUAGUU....................................................... 30 3 hsa-let-7a-2_L01_M J1_ES_demeth ..............UGAGGUAGUAGGUUGUAUAGUU....................................................... 3 3 hsa-let-7a-2_L02 J1_ES_untr ..............UGAGGUAGUAGGUUGUAUAGUUU...................................................... 1 3 hsa-let-7a-2_L03 J1_ES_demeth hsa-let-7a-3 chr22:44887273-44887386 + UGCCCUUUGGGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCUGAAGUGGCUG .((((((..(((.(((..((((((((((((((((((((((...)))))).........))))))))))))))))..))))))..))).))).. (-46.00) ............UGAGGUAGUAGGUUGUAUAGUU........................................................... 30 3 hsa-let-7a-3_L01_M J1_ES_demeth ............UGAGGUAGUAGGUUGUAUAGUU........................................................... 3 3 hsa-let-7a-3_L02 J1_ES_untr ............UGAGGUAGUAGGUUGUAUAGUUU.......................................................... 1 3 hsa-let-7a-3_L03 J1_ES_demeth hsa-let-7b chr22:44888210-44888332 + CGGGCCUGGCGGGGUGAGGUAGUAGGUUGUGUGGUUUCAGGGCAGUGAUGUUGCCCCUCGGAAGAUAACUAUACAACCUACUGCCUUCCCUGAGGAGCCCAG .((((((..(((((.(((((((((((((((((((((...((((((.....)))))).((....)).)))))))))))))))))))))))))).)).)))).. (-63.00) ..............UGAGGUAGUAGGUUGUGUGGUU.................................................................. 1 1 hsa-let-7b_L01_M J1_ES_untr hsa-let-7c chr21:16833999-16834122 + AAGCUGUGUGCAUCCGGGUUGAGGUAGUAGGUUGUAUGGUUUAGAGUUACACCCUGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUGGAGCACACUUGAGC ..(((((((((.((((((..(((.(((.(((((((((((((..((.(..(.....)..).))))))))))))))).))).)))..))))))))))))...))) (-44.10) ...................UGAGGUAGUAGGUUGUAUGGUU.............................................................. 11 1 hsa-let-7c_L01_M J1_ES_demeth ...................UGAGGUAGUAGGUUGUAUGGUU.............................................................. 8 1 hsa-let-7c_L02 J1_ES_untr ...................UGAGGUAGUAGGUUGUAUGGUUU............................................................. 2 1 hsa-let-7c_L03 J1_ES_untr ...................UGAGGUAGUAGGUUGUAUGGU............................................................... 1 1 hsa-let-7c_L04 ES_Dicer ...................UGAGGUAGUAGGUUGUAUGG................................................................ 1 1 hsa-let-7c_L05 ES_Dicer ...................UGAGGUAGUAGGUUGUAUGGUU.............................................................. 1 1 hsa-let-7c_L06 ES_Dicer ...................UGAGGUAGUAGGUUGUAUGGU............................................................... 1 1 hsa-let-7c_L07 J1_ES_demeth hsa-let-7d chr9:95980917-95981043 + AAAAAAAUGGGUUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUUAU .....((((((..(((((((.((((((((((((((.((((((...((((((.....)))))).(.....)..)))))).)))))))))))))))))))))..)))))).. (-50.20) ....................AGAGGUAGUAGGUUGCAUAGUU.................................................................... 4 1 hsa-let-7d_L01_M J1_ES_demeth ............................................................................AUACGACCUGCUGCCUUUC............... 1 1 hsa-let-7d_R01*_M ES_Dicer-DEL hsa-let-7e chr19:56887831-56887949 + GCCGCGCCCCCCGGGCUGAGGUAGGAGGUUGUAUAGUUGAGGAGGACACCCAAGGAGAUCACUAUACGGCCUCCUAGCUUUCCCCAGGCUGCGCCCUG ...((((..((.(((..(((.((((((((((((((((.((...((....)).......)))))))))))))))))).)))..))).))..)))).... (-46.90) ................UGAGGUAGGAGGUUGUAUAGUU............................................................ 67 1 hsa-let-7e_L01_M J1_ES_demeth ................UGAGGUAGGAGGUUGUAUAGU............................................................. 6 1 hsa-let-7e_L02 J1_ES_demeth ................UGAGGUAGGAGGUUGUAUAGUUG........................................................... 4 1 hsa-let-7e_L03 J1_ES_demeth ................UGAGGUAGGAGGUUGUAUAGUU............................................................ 2 1 hsa-let-7e_L04 ES_Dicer ................UGAGGUAGGAGGUUGUAUAGUU............................................................ 2 1 hsa-let-7e_L05 J1_ES_untr ................UGAGGUAGGAGGUUGUAUAGUUG........................................................... 1 1 hsa-let-7e_L06 J1_ES_untr .................GAGGUAGGAGGUUGUAUAGUUG........................................................... 1 1 hsa-let-7e_L07 J1_ES_demeth hsa-let-7f-1 chr9:95978430-95978556 + AAAACAUUGCUCUAUCAGAGUGAGGUAGUAGAUUGUAUAGUUGUGGGGUAGUGAUUUUACCCUGUUCAGGAGAUAACUAUACAAUCUAUUGCCUUCCCUGAGGAGUAGACU ......(((((((.((((.(..(((((((((((((((((((((((((((((.....))))))).........))))))))))))))))))))))..))))))))))))... (-51.90) ....................UGAGGUAGUAGAUUGUAUAGUU..................................................................... 12 2 hsa-let-7f-1_L01_M J1_ES_demeth ....................UGAGGUAGUAGAUUGUAUAGUU..................................................................... 1 2 hsa-let-7f-1_L02 J1_ES_untr hsa-let-7f-2 chrX:53600858-53600980 - ACUGGUGCUCUGUGGGAUGAGGUAGUAGAUUGUAUAGUUUUAGGGUCAUACCCCAUCUUGGAGAUAACUAUACAGUCUACUGUCUUUCCCACGGUGGUACAC ....(((((((((((((.(((..((((((((((((((((...(((.....))).(((.....)))))))))))))))))))..))))))))))).))))).. (-49.70) .................UGAGGUAGUAGAUUGUAUAGUU............................................................... 12 2 hsa-let-7f-2_L01_M J1_ES_demeth .................UGAGGUAGUAGAUUGUAUAGUU............................................................... 1 2 hsa-let-7f-2_L02 J1_ES_untr ...................................................................CUAUACAGUCUACUGUCUU................ 1 1 hsa-let-7f-2_R01*_M J1_ES_demeth hsa-let-7g chr3:52277314-52277437 - GCCUGAUUCCAGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCAGGAACAGCG ((.((.((((.(((.((((((((.((((((((((((.....((((.((.((((....))))))..)))))))))))))))).))))))))))).)))))))). (-48.00) ..............UGAGGUAGUAGUUUGUACAGUU................................................................... 26 1 hsa-let-7g_L01_M J1_ES_demeth ..............UGAGGUAGUAGUUUGUACAGUU................................................................... 4 1 hsa-let-7g_L02 J1_ES_untr ..............UGAGGUAGUAGUUUGUACAGUU................................................................... 1 1 hsa-let-7g_L03 ES_Dicer ..............UGAGGUAGUAGUUUGUACAGUUU.................................................................. 1 1 hsa-let-7g_L04 J1_ES_untr ..............UGAGGUAGUAGUUUGUACAGUUU.................................................................. 1 1 hsa-let-7g_L05 J1_ES_demeth ..............UGAGGUAGUAGUUUGUACAGU.................................................................... 1 1 hsa-let-7g_L06 J1_ES_demeth hsa-let-7i chr12:61283713-61283836 + ACCAUGGCCCUGGCUGAGGUAGUAGUUUGUGCUGUUGGUCGGGUUGUGACAUUGCCCGCUGUGGAGAUAACUGCGCAAGCUACUGCCUUGCUAGUGCUGGUGAU ((((..((.(((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))).))))))... (-49.50) ..............UGAGGUAGUAGUUUGUGCUGUU.................................................................... 3 1 hsa-let-7i_L01_M J1_ES_demeth hsa-mir-1-1 chr20:60561938-60562048 + CUGCCUGCUUGGGAAACAUACUUCUUUAUAUGCCCAUAUGGACCUGCUAAGCUAUGGAAUGUAAAGAAGUAUGUAUCUCAGGCCGGGACC ...((.((((((((.((((((((((((((((..((((((((.....)))...))))).)))))))))))))))).)))))))).)).... (-40.90) ......................................................UGGAAUGUAAAGAAGUAUGUAU.............. 4 2 hsa-mir-1-1_R01_M J1_ES_demeth ......................................................UGGAAUGUAAAGAAGUAUGUAU.............. 3 2 hsa-mir-1-1_R02 ES_Dicer ......................................................UGGAAUGUAAAGAAGUAUGUAU.............. 3 2 hsa-mir-1-1_R03 J1_ES_untr ......................................................UGGAAUGUAAAGAAGUAUGUA............... 1 2 hsa-mir-1-1_R04 J1_ES_demeth hsa-mir-1-2 chr18:17662943-17663067 - AACUUAGUAAUACCUACUCAGAGUACAUACUUCUUUAUGUACCCAUAUGAACAUACAAUGCUAUGGAAUGUAAAGAAGUAUGUAUUUUUGGUAGGCAAUAAACCA ............((((((.(((((((((((((((((((((..(((((..............))))).))))))))))))))))))))).)))))).......... (-35.64) ...............................................................UGGAAUGUAAAGAAGUAUGUAU.................... 4 2 hsa-mir-1-2_R01_M J1_ES_demeth ...............................................................UGGAAUGUAAAGAAGUAUGUAU.................... 3 2 hsa-mir-1-2_R02 ES_Dicer ...............................................................UGGAAUGUAAAGAAGUAUGUAU.................... 3 2 hsa-mir-1-2_R03 J1_ES_untr ...............................................................UGGAAUGUAAAGAAGUAUGUA..................... 1 2 hsa-mir-1-2_R04 J1_ES_demeth hsa-mir-100 chr11:121528127-121528246 - GAUAUUGAGGCCUGUUGCCACAAACCCGUAGAUCCGAACUUGUGGUAUUAGUCCGCACAAGCUUGUAUCUAUAGGUAUGUGUCUGUUAGGCAAUCUCAC .....(((((((((..(.((((.(((..(((((.(((.(((((((........).)))))).))).)))))..))).)))).)...)))))...)))). (-33.80) ......................AACCCGUAGAUCCGAACUUGUG....................................................... 1 1 hsa-mir-100_L01_M J1_ES_demeth hsa-mir-101-1 chr1:65296685-65296799 - ACUGACAGGCUGCCCUGGCUCAGUUAUCACAGUGCUGAUGCUGUCUAUUCUAAAGGUACAGUACUGUGAUAACUGAAGGAUGGCAGCCAUCUUA .......(((((((.....((((((((((((((((((.((((............)))))))))))))))))))))).....)))))))...... (-47.30) ....................CAGUUAUCACAGUGCUGAUGCU.................................................... 2 1 hsa-mir-101-1_L01*_M J1_ES_untr ....................CAGUUAUCACAGUGCUGAUGCU.................................................... 1 1 hsa-mir-101-1_L02* ES_Dicer ....................CAGUUAUCACAGUGCUGAUG...................................................... 1 1 hsa-mir-101-1_L03* ES_Dicer ...................UCAGUUAUCACAGUGCUGAUGC..................................................... 1 1 hsa-mir-101-1_L04* ES_Dicer ....................CAGUUAUCACAGUGCUGAUGCUG................................................... 1 1 hsa-mir-101-1_L05* ES_Dicer ...................UCAGUUAUCACAGUGCUGAUGCU.................................................... 1 1 hsa-mir-101-1_L06* J1_ES_demeth ...................UCAGUUAUCACAGUGCUGAUGC..................................................... 1 1 hsa-mir-101-1_L07* J1_ES_demeth ...................UCAGUUAUCACAGUGCUGAUGC..................................................... 1 1 hsa-mir-101-1_L08* J1_ES_untr ...................UCAGUUAUCACAGUGCUGAUG...................................................... 1 1 hsa-mir-101-1_L09* J1_ES_untr ...................UCAGUUAUCACAGUGCUGAUGCU.................................................... 1 1 hsa-mir-101-1_L10* ES_Dicer-DEL .......................................................GUACAGUACUGUGAUAACUGAA................. 57 2 hsa-mir-101-1_R01_M J1_ES_demeth ........................................................UACAGUACUGUGAUAACUGAA................. 38 2 hsa-mir-101-1_R02 ES_Dicer ........................................................UACAGUACUGUGAUAACUGAA................. 34 2 hsa-mir-101-1_R03 J1_ES_demeth ........................................................UACAGUACUGUGAUAACUGAAG................ 31 2 hsa-mir-101-1_R04 J1_ES_demeth .......................................................GUACAGUACUGUGAUAACUGAA................. 31 2 hsa-mir-101-1_R05 J1_ES_untr ........................................................UACAGUACUGUGAUAACUGAAG................ 29 2 hsa-mir-101-1_R06 ES_Dicer .......................................................GUACAGUACUGUGAUAACUGAA................. 24 2 hsa-mir-101-1_R07 ES_Dicer ........................................................UACAGUACUGUGAUAACUGAAG................ 20 2 hsa-mir-101-1_R08 J1_ES_untr .......................................................GUACAGUACUGUGAUAACUGA.................. 16 2 hsa-mir-101-1_R09 J1_ES_demeth ........................................................UACAGUACUGUGAUAACUGAA................. 16 2 hsa-mir-101-1_R10 J1_ES_untr .......................................................GUACAGUACUGUGAUAACUGA.................. 9 2 hsa-mir-101-1_R11 ES_Dicer ........................................................UACAGUACUGUGAUAACUGA.................. 8 2 hsa-mir-101-1_R12 ES_Dicer .......................................................GUACAGUACUGUGAUAACUGA.................. 7 2 hsa-mir-101-1_R13 J1_ES_untr ........................................................UACAGUACUGUGAUAACUGA.................. 4 2 hsa-mir-101-1_R14 J1_ES_demeth .......................................................GUACAGUACUGUGAUAACU.................... 2 2 hsa-mir-101-1_R15 ES_Dicer ........................................................UACAGUACUGUGAUAACU.................... 1 2 hsa-mir-101-1_R16 ES_Dicer ...........................................................AGUACUGUGAUAACUGAAG................ 1 2 hsa-mir-101-1_R17 ES_Dicer ........................................................UACAGUACUGUGAUAACUG................... 1 2 hsa-mir-101-1_R18 ES_Dicer .......................................................GUACAGUACUGUGAUAACU.................... 1 2 hsa-mir-101-1_R19 J1_ES_demeth ........................................................UACAGUACUGUGAUAACUGA.................. 1 2 hsa-mir-101-1_R20 J1_ES_untr hsa-mir-101-2 chr9:4840277-4840395 + UGAGACUGAACUGUCCUUUUUCGGUUAUCAUGGUACCGAUGCUGUAUAUCUGAAAGGUACAGUACUGUGAUAACUGAAGAAUGGUGGUGCCAUCACAUU ...((.((.((..((.((((((((((((((((((((.(.((((............))))).)))))))))))))))))))).))..))..))))..... (-34.20) ........................................................GUACAGUACUGUGAUAACUGAA..................... 57 2 hsa-mir-101-2_R01_M J1_ES_demeth .........................................................UACAGUACUGUGAUAACUGAA..................... 38 2 hsa-mir-101-2_R02 ES_Dicer .........................................................UACAGUACUGUGAUAACUGAA..................... 34 2 hsa-mir-101-2_R03 J1_ES_demeth ........................................................GUACAGUACUGUGAUAACUGAA..................... 31 2 hsa-mir-101-2_R04 J1_ES_untr .........................................................UACAGUACUGUGAUAACUGAAG.................... 31 2 hsa-mir-101-2_R05 J1_ES_demeth .........................................................UACAGUACUGUGAUAACUGAAG.................... 29 2 hsa-mir-101-2_R06 ES_Dicer ........................................................GUACAGUACUGUGAUAACUGAA..................... 24 2 hsa-mir-101-2_R07 ES_Dicer .........................................................UACAGUACUGUGAUAACUGAAG.................... 20 2 hsa-mir-101-2_R08 J1_ES_untr .........................................................UACAGUACUGUGAUAACUGAA..................... 16 2 hsa-mir-101-2_R09 J1_ES_untr ........................................................GUACAGUACUGUGAUAACUGA...................... 16 2 hsa-mir-101-2_R10 J1_ES_demeth ........................................................GUACAGUACUGUGAUAACUGA...................... 9 2 hsa-mir-101-2_R11 ES_Dicer .........................................................UACAGUACUGUGAUAACUGA...................... 8 2 hsa-mir-101-2_R12 ES_Dicer ........................................................GUACAGUACUGUGAUAACUGA...................... 7 2 hsa-mir-101-2_R13 J1_ES_untr .........................................................UACAGUACUGUGAUAACUGA...................... 4 2 hsa-mir-101-2_R14 J1_ES_demeth ........................................................GUACAGUACUGUGAUAACU........................ 2 2 hsa-mir-101-2_R15 ES_Dicer .........................................................UACAGUACUGUGAUAACU........................ 1 2 hsa-mir-101-2_R16 ES_Dicer ............................................................AGUACUGUGAUAACUGAAG.................... 1 2 hsa-mir-101-2_R17 ES_Dicer .........................................................UACAGUACUGUGAUAACUG....................... 1 2 hsa-mir-101-2_R18 ES_Dicer .........................................................UACAGUACUGUGAUAACUGA...................... 1 2 hsa-mir-101-2_R19 J1_ES_untr .........................................................UACAGUACUGUGAUAACUGAAGA................... 1 1 hsa-mir-101-2_R20 J1_ES_untr ........................................................GUACAGUACUGUGAUAACU........................ 1 2 hsa-mir-101-2_R21 J1_ES_demeth .........................................................UACAGUACUGUGAUAACUGAAGA................... 1 1 hsa-mir-101-2_R22 J1_ES_demeth hsa-mir-103-1 chr5:167920459-167920576 - GAAGUUUUCUUACUGCCCUCGGCUUCUUUACAGUGCUGCCUUGUUGCAUAUGGAUCAAGCAGCAUUGUACAGGGCUAUGAAGGCAUUGAGACCUGUUCUUCAUG ((((...(((((.((((.((((((.((.(((((((((((.(((.(.(....).).)))))))))))))).))))))..)).)))).)))))......))))... (-39.00) ....................GGCUUCUUUACAGUGCUGCCUUGU............................................................ 3 1 hsa-mir-103-1_L01*_M J1_ES_demeth .....................GCUUCUUUACAGUGCUGCCUUGU............................................................ 1 2 hsa-mir-103-1_L02* J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAUGA........................ 229 2 hsa-mir-103-1_R01_M J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAUGA........................ 94 2 hsa-mir-103-1_R02 J1_ES_untr .........................................................AGCAGCAUUGUACAGGGCUAUG......................... 17 2 hsa-mir-103-1_R03 J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAUGAA....................... 13 2 hsa-mir-103-1_R04 J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAU.......................... 13 3 hsa-mir-103-1_R05 J1_ES_demeth ...........................................................CAGCAUUGUACAGGGCUAUGA........................ 10 2 hsa-mir-103-1_R06 J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAUG......................... 8 2 hsa-mir-103-1_R07 J1_ES_untr .........................................................AGCAGCAUUGUACAGGGCUAUGA........................ 7 2 hsa-mir-103-1_R08 ES_Dicer .........................................................AGCAGCAUUGUACAGGGCUAUG......................... 5 2 hsa-mir-103-1_R09 ES_Dicer .........................................................AGCAGCAUUGUACAGGGCUAUGAA....................... 4 2 hsa-mir-103-1_R10 J1_ES_untr .........................................................AGCAGCAUUGUACAGGGCUA........................... 3 3 hsa-mir-103-1_R11 ES_Dicer .........................................................AGCAGCAUUGUACAGGGCUAU.......................... 2 3 hsa-mir-103-1_R12 J1_ES_untr .........................................................AGCAGCAUUGUACAGGGCUA........................... 2 3 hsa-mir-103-1_R13 J1_ES_demeth ...........................................................CAGCAUUGUACAGGGCUAUG......................... 2 2 hsa-mir-103-1_R14 J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAU.......................... 1 3 hsa-mir-103-1_R15 ES_Dicer ..........................................................GCAGCAUUGUACAGGGCUAUGA........................ 1 2 hsa-mir-103-1_R16 ES_Dicer ...........................................................CAGCAUUGUACAGGGCUAUGA........................ 1 2 hsa-mir-103-1_R17 J1_ES_untr ..............................................................CAUUGUACAGGGCUAUGA........................ 1 2 hsa-mir-103-1_R18 J1_ES_demeth .........................................................AGCAGCAUUGUACAGGGCUAUGAAG...................... 1 1 hsa-mir-103-1_R19 J1_ES_demeth ...........................................................CAGCAUUGUACAGGGCUAUGAA....................... 1 2 hsa-mir-103-1_R20 J1_ES_demeth hsa-mir-103-2 chr20:3846121-3846238 + GCUGCGUCUUUGUGCUUUCAGCUUCUUUACAGUGCUGCCUUGUAGCAUUCAGGUCAAGCAGCAUUGUACAGGGCUAUGAAAGAACCAAGAAUGGGCU (((...((((.((.(((((((((.((.(((((((((((((((.......))))....))))))))))).)))))..)))))).)).))))...))). (-36.00) ...................AGCUUCUUUACAGUGCUGCCUUG....................................................... 20 1 hsa-mir-103-2_L01*_M J1_ES_demeth ...................AGCUUCUUUACAGUGCUGCCUUGU...................................................... 19 1 hsa-mir-103-2_L02* J1_ES_demeth ...................AGCUUCUUUACAGUGCUGCCUUG....................................................... 15 1 hsa-mir-103-2_L03* J1_ES_untr ...................AGCUUCUUUACAGUGCUGCCUUGU...................................................... 10 1 hsa-mir-103-2_L04* J1_ES_untr ...................AGCUUCUUUACAGUGCUGCCUUG....................................................... 4 1 hsa-mir-103-2_L05* ES_Dicer ..................CAGCUUCUUUACAGUGCUGCCUUG....................................................... 2 1 hsa-mir-103-2_L06* ES_Dicer ...................AGCUUCUUUACAGUGCUGCCUUGU...................................................... 2 1 hsa-mir-103-2_L07* ES_Dicer ....................GCUUCUUUACAGUGCUGCCUUGU...................................................... 1 2 hsa-mir-103-2_L08* J1_ES_demeth ...................AGCUUCUUUACAGUGCUGCCUUGUA..................................................... 1 1 hsa-mir-103-2_L09* J1_ES_demeth ...................AGCUUCUUUACAGUGCUGCCU......................................................... 1 1 hsa-mir-103-2_L10* J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAUGA.................. 229 2 hsa-mir-103-2_R01_M J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAUGA.................. 94 2 hsa-mir-103-2_R02 J1_ES_untr ........................................................AGCAGCAUUGUACAGGGCUAUG................... 17 2 hsa-mir-103-2_R03 J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAUGAA................. 13 2 hsa-mir-103-2_R04 J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAU.................... 13 3 hsa-mir-103-2_R05 J1_ES_demeth ..........................................................CAGCAUUGUACAGGGCUAUGA.................. 10 2 hsa-mir-103-2_R06 J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAUG................... 8 2 hsa-mir-103-2_R07 J1_ES_untr ........................................................AGCAGCAUUGUACAGGGCUAUGA.................. 7 2 hsa-mir-103-2_R08 ES_Dicer ........................................................AGCAGCAUUGUACAGGGCUAUG................... 5 2 hsa-mir-103-2_R09 ES_Dicer ........................................................AGCAGCAUUGUACAGGGCUAUGAA................. 4 2 hsa-mir-103-2_R10 J1_ES_untr ........................................................AGCAGCAUUGUACAGGGCUA..................... 3 3 hsa-mir-103-2_R11 ES_Dicer ........................................................AGCAGCAUUGUACAGGGCUAUGAAA................ 3 1 hsa-mir-103-2_R12 J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAU.................... 2 3 hsa-mir-103-2_R13 J1_ES_untr ..........................................................CAGCAUUGUACAGGGCUAUG................... 2 2 hsa-mir-103-2_R14 J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUA..................... 2 3 hsa-mir-103-2_R15 J1_ES_demeth ........................................................AGCAGCAUUGUACAGGGCUAU.................... 1 3 hsa-mir-103-2_R16 ES_Dicer .........................................................GCAGCAUUGUACAGGGCUAUGA.................. 1 2 hsa-mir-103-2_R17 ES_Dicer ..........................................................CAGCAUUGUACAGGGCUAUGA.................. 1 2 hsa-mir-103-2_R18 J1_ES_untr .............................................................CAUUGUACAGGGCUAUGA.................. 1 2 hsa-mir-103-2_R19 J1_ES_demeth ..........................................................CAGCAUUGUACAGGGCUAUGAA................. 1 2 hsa-mir-103-2_R20 J1_ES_demeth ..........................................................CAGCAUUGUACAGGGCUAUGAAA................ 1 1 hsa-mir-103-2_R21 J1_ES_demeth hsa-mir-106a chrX:133131874-133131994 - CAGGAAUAGGCCUUGGCCAUGUAAAAGUGCUUACAGUGCAGGUAGCUUUUUGAGAUCUACUGCAAUGUAAGCACUUCUUACAUUACCAUGGUGAUUUAGU ...((((..(((.(((..(((((((((((((((((.(((((.(((.((.....)).)))))))).))))))))))).))))))..))).))).))))... (-38.80) ......................AAAAGUGCUUACAGUGCAGGUAG....................................................... 3 1 hsa-mir-106a_L01_M J1_ES_untr ..........................GUGCUUACAGUGCAGGUAG....................................................... 2 2 hsa-mir-106a_L02 ES_Dicer ......................AAAAGUGCUUACAGUGCAGGUAG....................................................... 2 1 hsa-mir-106a_L03 J1_ES_demeth .........................AGUGCUUACAGUGCAGGUAG....................................................... 1 2 hsa-mir-106a_L04 ES_Dicer ......................AAAAGUGCUUACAGUGCAGGUAG....................................................... 1 1 hsa-mir-106a_L05 ES_Dicer ...........................UGCUUACAGUGCAGGUAG....................................................... 1 2 hsa-mir-106a_L06 ES_Dicer .......................AAAGUGCUUACAGUGCAGGUAG....................................................... 1 2 hsa-mir-106a_L07 J1_ES_untr ..........................GUGCUUACAGUGCAGGUAGC...................................................... 1 1 hsa-mir-106a_L08 ES_Dicer-DEL hsa-mir-106b chr7:99529532-99529653 - UCCCCACCUCCCGCUCCAGCCCUGCCGGGGCUAAAGUGCUGACAGUGCAGAUAGUGGUCCUCUCCGUGCUACCGCACUGUGGGUACUUGCUGCUCCAGCAGGGCACGCACAGCGUCCGUGG ...((((....((((...(((((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))))......))))...)))) (-60.10) ...............................UAAAGUGCUGACAGUGCAGAUA.................................................................... 234 1 hsa-mir-106b_L01_M ES_Dicer ...............................UAAAGUGCUGACAGUGCAGAU..................................................................... 141 1 hsa-mir-106b_L02 ES_Dicer ...............................UAAAGUGCUGACAGUGCAGAUA.................................................................... 126 1 hsa-mir-106b_L03 J1_ES_demeth ...............................UAAAGUGCUGACAGUGCAGAUA.................................................................... 67 1 hsa-mir-106b_L04 J1_ES_untr ...............................UAAAGUGCUGACAGUGCAGAU..................................................................... 39 1 hsa-mir-106b_L05 J1_ES_demeth ...............................UAAAGUGCUGACAGUGCAGAU..................................................................... 19 1 hsa-mir-106b_L06 J1_ES_untr ...............................UAAAGUGCUGACAGUGCAGA...................................................................... 8 1 hsa-mir-106b_L07 J1_ES_demeth ...............................UAAAGUGCUGACAGUGCAGA...................................................................... 7 1 hsa-mir-106b_L08 ES_Dicer ...............................UAAAGUGCUGACAGUGCAGAUAG................................................................... 4 1 hsa-mir-106b_L09 ES_Dicer ...............................UAAAGUGCUGACAGUGCAGAUAG................................................................... 3 1 hsa-mir-106b_L10 J1_ES_untr ...............................UAAAGUGCUGACAGUGCAGAUAG................................................................... 2 1 hsa-mir-106b_L11 J1_ES_demeth ...............................UAAAGUGCUGACAGUGCAG....................................................................... 2 1 hsa-mir-106b_L12 ES_Dicer-DEL .................................AAGUGCUGACAGUGCAGAU..................................................................... 1 1 hsa-mir-106b_L13 ES_Dicer ................................AAAGUGCUGACAGUGCAGAU..................................................................... 1 1 hsa-mir-106b_L14 ES_Dicer ................................AAAGUGCUGACAGUGCAGAUA.................................................................... 1 1 hsa-mir-106b_L15 ES_Dicer ...............................UAAAGUGCUGACAGUGCAGAUAGU.................................................................. 1 1 hsa-mir-106b_L16 J1_ES_demeth .................................AAGUGCUGACAGUGCAGAUA.................................................................... 1 1 hsa-mir-106b_L17 J1_ES_untr ...............................UAAAGUGCUGACAGUGCAGA...................................................................... 1 1 hsa-mir-106b_L18 J1_ES_untr ...................................GUGCUGACAGUGCAGAUA.................................................................... 1 1 hsa-mir-106b_L19 J1_ES_untr ...............................UAAAGUGCUGACAGUGCAGAUAG................................................................... 1 1 hsa-mir-106b_L20 ES_Dicer-DEL .......................................................................CCGCACUGUGGGUACUUGCUG............................. 46 1 hsa-mir-106b_R01*_M J1_ES_demeth .......................................................................CCGCACUGUGGGUACUUGCUGC............................ 32 1 hsa-mir-106b_R02* J1_ES_demeth .......................................................................CCGCACUGUGGGUACUUGCUG............................. 21 1 hsa-mir-106b_R03* J1_ES_untr .......................................................................CCGCACUGUGGGUACUUGCUGC............................ 20 1 hsa-mir-106b_R04* J1_ES_untr .......................................................................CCGCACUGUGGGUACUUGCUGC............................ 8 1 hsa-mir-106b_R05* ES_Dicer .......................................................................CCGCACUGUGGGUACUUGCUG............................. 8 1 hsa-mir-106b_R06* ES_Dicer .......................................................................CCGCACUGUGGGUACUUGCU.............................. 8 1 hsa-mir-106b_R07* J1_ES_demeth .......................................................................CCGCACUGUGGGUACUUGCU.............................. 4 1 hsa-mir-106b_R08* J1_ES_untr .......................................................................CCGCACUGUGGGUACUUGCUGCU........................... 2 1 hsa-mir-106b_R09* J1_ES_demeth .......................................................................CCGCACUGUGGGUACUUGC............................... 2 1 hsa-mir-106b_R10* J1_ES_demeth .......................................................................CCGCACUGUGGGUACUUGCU.............................. 1 1 hsa-mir-106b_R11* ES_Dicer .......................................................................CCGCACUGUGGGUACUUG................................ 1 1 hsa-mir-106b_R12* J1_ES_demeth .......................................................................CCGCACUGUGGGUACUUGCUGCU........................... 1 1 hsa-mir-106b_R13* J1_ES_untr hsa-mir-107 chr10:91342464-91342584 - UGCAAUAUUCGAUAUUCUCUCUGCUUUCAGCUUCUUUACAGUGUUGCCUUGUGGCAUGGAGUUCAAGCAGCAUUGUACAGGGCUAUCAAAGCACAGAGAGCUUGCU .((((.........((((((.((((((.((((.((.(((((((((((.(((.(((.....))))))))))))))))).))))))...)))))).)))))).)))). (-35.80) ............................AGCUUCUUUACAGUGUUGCCU......................................................... 1 1 hsa-mir-107_L01*_M J1_ES_demeth .................................................................AGCAGCAUUGUACAGGGCUAU.................... 13 3 hsa-mir-107_R01_M J1_ES_demeth .................................................................AGCAGCAUUGUACAGGGCUAUCA.................. 5 1 hsa-mir-107_R02 J1_ES_demeth .................................................................AGCAGCAUUGUACAGGGCUA..................... 3 3 hsa-mir-107_R03 ES_Dicer .................................................................AGCAGCAUUGUACAGGGCUAU.................... 2 3 hsa-mir-107_R04 J1_ES_untr .................................................................AGCAGCAUUGUACAGGGCUAUCA.................. 2 1 hsa-mir-107_R05 J1_ES_untr .................................................................AGCAGCAUUGUACAGGGCUA..................... 2 3 hsa-mir-107_R06 J1_ES_demeth .................................................................AGCAGCAUUGUACAGGGCUAU.................... 1 3 hsa-mir-107_R07 ES_Dicer hsa-mir-10a chr17:44012179-44012328 - GGGCCAAGAAGAUCUGUCUGUCUUCUGUAUAUACCCUGUAGAUCCGAAUUUGUGUAAGGAAUUUUGUGGUCACAAAUUCGUAUCUAGGGGAAUAUGUAGUUGACAUAAACACUCCGCUCUUAUUUUUCCAGAAG ((((..((.(((....)))(((..((((((((.((((.(((((.((((((((((................)))))))))).))))))))).))))))))..))).......))..))))............... (-36.19) ...............................UACCCUGUAGAUCCGAAUUUGUG................................................................................ 2 1 hsa-mir-10a_L01_M J1_ES_demeth ...............................UACCCUGUAGAUCCGAAUUUGU................................................................................. 1 1 hsa-mir-10a_L02 J1_ES_demeth ...............................UACCCUGUAGAUCCGAAUUUGUG................................................................................ 1 1 hsa-mir-10a_L03 J1_ES_untr ...............................UACCCUGUAGAUCCGAAUUUGU................................................................................. 1 1 hsa-mir-10a_L04 J1_ES_untr hsa-mir-10b chr2:176723257-176723406 + GGGUGGGACCCAGAGGUUGUAACGUUGUCUAUAUAUACCCUGUAGAACCGAAUUUGUGUGGUAUCCGUAUAGUCACAGAUUCGAUUCUAGGGGAAUAUAUGGUCGAUGCAAAAACUUCACGUUUCUUCG (((.....))).((((((....(((((.((((((((.((((.(((((.((((((((((..(((....)))...)))))))))).))))))))).)))))))).)))))....))))))........... (-49.40) ...................................UACCCUGUAGAACCGAAUUUGU........................................................................ 3 1 hsa-mir-10b_L01_M J1_ES_demeth ...................................UACCCUGUAGAACCGAAUUUGUG....................................................................... 1 1 hsa-mir-10b_L02 J1_ES_demeth ....................................ACCCUGUAGAACCGAAUUUGU........................................................................ 1 1 hsa-mir-10b_L03 J1_ES_demeth hsa-mir-1197 chr14:100561634-100561761 + GGUCAGCGUCACUUCCUGGUAUUUGAAGAUGCGGUUGACCAUGGUGUGUACGCUUUAUUUGUGACGUAGGACACAUGGUCUACUUCUUCUCAAUAUCACAUCUCGCCU .....(((........(((((((.(((((...(((.(((((((...(.(((((.........).)))).)...))))))).))))))))..))))))).....))).. (-29.32) ..................................................................UAGGACACAUGGUCUACUUCU..................... 7 1 hsa-mir-1197_R01_M J1_ES_demeth ..................................................................UAGGACACAUGGUCUACUUCU..................... 2 1 hsa-mir-1197_R02 ES_Dicer ..................................................................UAGGACACAUGGUCUACUUCU..................... 2 1 hsa-mir-1197_R03 J1_ES_untr hsa-mir-122 chr18:54269266-54269390 + ACAGAGUUUCCUUAGCAGAGCUGUGGAGUGUGACAAUGGUGUUUGUGUCUAAACUAUCAAACGCCAUUAUCACACUAAAUAGCUACUGCUAGGCAAUCCUUCCC ..((..((.(((.(((((((((((..(((((((.(((((((((((.((....))...))))))))))).)))))))..)))))).)))))))).))..)).... (-47.20) .......................UGGAGUGUGACAAUGGUGU.............................................................. 1 1 hsa-mir-122_L01_M ES_Dicer-DEL .......................UGGAGUGUGACAAUGGUGUUU............................................................ 1 1 hsa-mir-122_L02 ES_Dicer-DEL hsa-mir-124-1 chr8:9798288-9798412 - CCUUUCCUUCCUCAGGAGAAAGGCCUCUCUCUCCGUGUUCACAGCGGACCUUGAUUUAAAUGUCCAUACAAUUAAGGCACGCGGUGAAUGCCAAGAAUGGGGCUGGCUGAGCAC ..........(((((......((((((..(((..((((((((.(((..((((((((.............))))))))..))).))))))))..)))..))))))..)))))... (-40.92) .................................CGUGUUCACAGCGGACCUUGAU........................................................... 12 3 hsa-mir-124-1_L01*_M J1_ES_demeth .................................CGUGUUCACAGCGGACCUUGAU........................................................... 5 3 hsa-mir-124-1_L02* ES_Dicer .................................CGUGUUCACAGCGGACCUUGAU........................................................... 4 3 hsa-mir-124-1_L03* J1_ES_untr .................................CGUGUUCACAGCGGACCUUGA............................................................ 3 3 hsa-mir-124-1_L04* J1_ES_demeth .................................CGUGUUCACAGCGGACCUUGAUU.......................................................... 3 3 hsa-mir-124-1_L05* J1_ES_demeth .................................CGUGUUCACAGCGGACCUUGAUU.......................................................... 2 3 hsa-mir-124-1_L06* J1_ES_untr .................................CGUGUUCACAGCGGACCUUGA............................................................ 1 3 hsa-mir-124-1_L07* J1_ES_untr ........................................................................UAAGGCACGCGGUGAAUGCCAA.................... 288 3 hsa-mir-124-1_R01_M J1_ES_demeth ........................................................................UAAGGCACGCGGUGAAUGCCAA.................... 159 3 hsa-mir-124-1_R02 ES_Dicer ........................................................................UAAGGCACGCGGUGAAUGCCA..................... 91 3 hsa-mir-124-1_R03 J1_ES_demeth ........................................................................UAAGGCACGCGGUGAAUGCCA..................... 81 3 hsa-mir-124-1_R04 ES_Dicer ........................................................................UAAGGCACGCGGUGAAUGCCAA.................... 75 3 hsa-mir-124-1_R05 J1_ES_untr ........................................................................UAAGGCACGCGGUGAAUGCCA..................... 27 3 hsa-mir-124-1_R06 J1_ES_untr .......................................................................UUAAGGCACGCGGUGAAUGCCAA.................... 14 3 hsa-mir-124-1_R07 J1_ES_demeth ........................................................................UAAGGCACGCGGUGAAUGC....................... 10 3 hsa-mir-124-1_R08 J1_ES_demeth .......................................................................UUAAGGCACGCGGUGAAUGC....................... 10 3 hsa-mir-124-1_R09 J1_ES_demeth ........................................................................UAAGGCACGCGGUGAAUGC....................... 8 3 hsa-mir-124-1_R10 ES_Dicer .........................................................................AAGGCACGCGGUGAAUGCCAA.................... 8 3 hsa-mir-124-1_R11 ES_Dicer .......................................................................UUAAGGCACGCGGUGAAUGCCAA.................... 7 3 hsa-mir-124-1_R12 ES_Dicer ........................................................................UAAGGCACGCGGUGAAUGCC...................... 6 3 hsa-mir-124-1_R13 ES_Dicer .......................................................................UUAAGGCACGCGGUGAAUGCCAA.................... 5 3 hsa-mir-124-1_R14 J1_ES_untr .........................................................................AAGGCACGCGGUGAAUGCCAA.................... 5 3 hsa-mir-124-1_R15 J1_ES_demeth .......................................................................UUAAGGCACGCGGUGAAUGC....................... 4 3 hsa-mir-124-1_R16 ES_Dicer .......................................................................UUAAGGCACGCGGUGAAUGCCA..................... 4 3 hsa-mir-124-1_R17 ES_Dicer .......................................................................UUAAGGCACGCGGUGAAUGCCA..................... 4 3 hsa-mir-124-1_R18 J1_ES_demeth ........................................................................UAAGGCACGCGGUGAAUG........................ 3 3 hsa-mir-124-1_R19 ES_Dicer ........................................................................UAAGGCACGCGGUGAAUGC....................... 3 3 hsa-mir-124-1_R20 J1_ES_untr .......................................................................UUAAGGCACGCGGUGAAUGC....................... 2 3 hsa-mir-124-1_R21 J1_ES_untr ........................................................................UAAGGCACGCGGUGAAUGCCAAG................... 2 3 hsa-mir-124-1_R22 J1_ES_demeth .........................................................................AAGGCACGCGGUGAAUGCCA..................... 2 3 hsa-mir-124-1_R23 J1_ES_demeth ........................................................................UAAGGCACGCGGUGAAUGCC...................... 2 3 hsa-mir-124-1_R24 J1_ES_demeth .......................................................................UUAAGGCACGCGGUGAAUGCC...................... 1 3 hsa-mir-124-1_R25 ES_Dicer .........................................................................AAGGCACGCGGUGAAUGCCA..................... 1 3 hsa-mir-124-1_R26 ES_Dicer ........................................................................UAAGGCACGCGGUGAAUGCCAAG................... 1 3 hsa-mir-124-1_R27 ES_Dicer ........................................................................UAAGGCACGCGGUGAAUGCCAAGA.................. 1 3 hsa-mir-124-1_R28 J1_ES_untr .......................................................................UUAAGGCACGCGGUGAAUG........................ 1 3 hsa-mir-124-1_R29 J1_ES_demeth .......................................................................UUAAGGCACGCGGUGAAUGCC...................... 1 3 hsa-mir-124-1_R30 J1_ES_demeth hsa-mir-124-2 chr8:65454240-65454388 + ACUUUCCGGAUCAAGAUUAGAGGCUCUGCUCUCCGUGUUCACAGCGGACCUUGAUUUAAUGUCAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGCGGAGCCUACGGCUGCACUUGAAGGACACCAAA ....(((...(((((..(((((((((((((((..((((((((.(((..((((((((...........))))))))..))).))))))))..))))))))))))....)))..))))).)))....... (-54.20) .................................CGUGUUCACAGCGGACCUUGAU......................................................................... 12 3 hsa-mir-124-2_L01*_M J1_ES_demeth .................................CGUGUUCACAGCGGACCUUGAU......................................................................... 5 3 hsa-mir-124-2_L02* ES_Dicer .................................CGUGUUCACAGCGGACCUUGAU......................................................................... 4 3 hsa-mir-124-2_L03* J1_ES_untr .................................CGUGUUCACAGCGGACCUUGA.......................................................................... 3 3 hsa-mir-124-2_L04* J1_ES_demeth .................................CGUGUUCACAGCGGACCUUGAUU........................................................................ 3 3 hsa-mir-124-2_L05* J1_ES_demeth .................................CGUGUUCACAGCGGACCUUGAUU........................................................................ 2 3 hsa-mir-124-2_L06* J1_ES_untr .................................CGUGUUCACAGCGGACCUUGA.......................................................................... 1 3 hsa-mir-124-2_L07* J1_ES_untr ......................................................................UAAGGCACGCGGUGAAUGCCAA.................................... 288 3 hsa-mir-124-2_R01_M J1_ES_demeth ......................................................................UAAGGCACGCGGUGAAUGCCAA.................................... 159 3 hsa-mir-124-2_R02 ES_Dicer ......................................................................UAAGGCACGCGGUGAAUGCCA..................................... 91 3 hsa-mir-124-2_R03 J1_ES_demeth ......................................................................UAAGGCACGCGGUGAAUGCCA..................................... 81 3 hsa-mir-124-2_R04 ES_Dicer ......................................................................UAAGGCACGCGGUGAAUGCCAA.................................... 75 3 hsa-mir-124-2_R05 J1_ES_untr ......................................................................UAAGGCACGCGGUGAAUGCCA..................................... 27 3 hsa-mir-124-2_R06 J1_ES_untr .....................................................................UUAAGGCACGCGGUGAAUGCCAA.................................... 14 3 hsa-mir-124-2_R07 J1_ES_demeth ......................................................................UAAGGCACGCGGUGAAUGC....................................... 10 3 hsa-mir-124-2_R08 J1_ES_demeth .....................................................................UUAAGGCACGCGGUGAAUGC....................................... 10 3 hsa-mir-124-2_R09 J1_ES_demeth ......................................................................UAAGGCACGCGGUGAAUGC....................................... 8 3 hsa-mir-124-2_R10 ES_Dicer .......................................................................AAGGCACGCGGUGAAUGCCAA.................................... 8 3 hsa-mir-124-2_R11 ES_Dicer .....................................................................UUAAGGCACGCGGUGAAUGCCAA.................................... 7 3 hsa-mir-124-2_R12 ES_Dicer ......................................................................UAAGGCACGCGGUGAAUGCC...................................... 6 3 hsa-mir-124-2_R13 ES_Dicer .....................................................................UUAAGGCACGCGGUGAAUGCCAA.................................... 5 3 hsa-mir-124-2_R14 J1_ES_untr .......................................................................AAGGCACGCGGUGAAUGCCAA.................................... 5 3 hsa-mir-124-2_R15 J1_ES_demeth .....................................................................UUAAGGCACGCGGUGAAUGC....................................... 4 3 hsa-mir-124-2_R16 ES_Dicer .....................................................................UUAAGGCACGCGGUGAAUGCCA..................................... 4 3 hsa-mir-124-2_R17 ES_Dicer .....................................................................UUAAGGCACGCGGUGAAUGCCA..................................... 4 3 hsa-mir-124-2_R18 J1_ES_demeth ......................................................................UAAGGCACGCGGUGAAUG........................................ 3 3 hsa-mir-124-2_R19 ES_Dicer ......................................................................UAAGGCACGCGGUGAAUGC....................................... 3 3 hsa-mir-124-2_R20 J1_ES_untr .....................................................................UUAAGGCACGCGGUGAAUGC....................................... 2 3 hsa-mir-124-2_R21 J1_ES_untr ......................................................................UAAGGCACGCGGUGAAUGCCAAG................................... 2 3 hsa-mir-124-2_R22 J1_ES_demeth .......................................................................AAGGCACGCGGUGAAUGCCA..................................... 2 3 hsa-mir-124-2_R23 J1_ES_demeth ......................................................................UAAGGCACGCGGUGAAUGCC...................................... 2 3 hsa-mir-124-2_R24 J1_ES_demeth .....................................................................UUAAGGCACGCGGUGAAUGCC...................................... 1 3 hsa-mir-124-2_R25 ES_Dicer .......................................................................AAGGCACGCGGUGAAUGCCA..................................... 1 3 hsa-mir-124-2_R26 ES_Dicer ......................................................................UAAGGCACGCGGUGAAUGCCAAG................................... 1 3 hsa-mir-124-2_R27 ES_Dicer ......................................................................UAAGGCACGCGGUGAAUGCCAAGA.................................. 1 3 hsa-mir-124-2_R28 J1_ES_untr .....................................................................UUAAGGCACGCGGUGAAUG........................................ 1 3 hsa-mir-124-2_R29 J1_ES_demeth .....................................................................UUAAGGCACGCGGUGAAUGCC...................................... 1 3 hsa-mir-124-2_R30 J1_ES_demeth hsa-mir-124-3 chr20:61280277-61280403 + CCCCAGCCCUGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCCGCCGCUCCUU ....(((...(((((((.(((((.((((((((.(((..((((((((............))))))))..))).))))))))).)))).))).))))....))).... (-42.20) .......................CGUGUUCACAGCGGACCUUGAU............................................................. 12 3 hsa-mir-124-3_L01*_M J1_ES_demeth .......................CGUGUUCACAGCGGACCUUGAU............................................................. 5 3 hsa-mir-124-3_L02* ES_Dicer .......................CGUGUUCACAGCGGACCUUGAU............................................................. 4 3 hsa-mir-124-3_L03* J1_ES_untr .......................CGUGUUCACAGCGGACCUUGA.............................................................. 3 3 hsa-mir-124-3_L04* J1_ES_demeth .......................CGUGUUCACAGCGGACCUUGAUU............................................................ 3 3 hsa-mir-124-3_L05* J1_ES_demeth .......................CGUGUUCACAGCGGACCUUGAUU............................................................ 2 3 hsa-mir-124-3_L06* J1_ES_untr .......................CGUGUUCACAGCGGACCUUGA.............................................................. 1 3 hsa-mir-124-3_L07* J1_ES_untr .............................................................UAAGGCACGCGGUGAAUGCCAA....................... 288 3 hsa-mir-124-3_R01_M J1_ES_demeth .............................................................UAAGGCACGCGGUGAAUGCCAA....................... 159 3 hsa-mir-124-3_R02 ES_Dicer .............................................................UAAGGCACGCGGUGAAUGCCA........................ 91 3 hsa-mir-124-3_R03 J1_ES_demeth .............................................................UAAGGCACGCGGUGAAUGCCA........................ 81 3 hsa-mir-124-3_R04 ES_Dicer .............................................................UAAGGCACGCGGUGAAUGCCAA....................... 75 3 hsa-mir-124-3_R05 J1_ES_untr .............................................................UAAGGCACGCGGUGAAUGCCA........................ 27 3 hsa-mir-124-3_R06 J1_ES_untr ............................................................UUAAGGCACGCGGUGAAUGCCAA....................... 14 3 hsa-mir-124-3_R07 J1_ES_demeth .............................................................UAAGGCACGCGGUGAAUGC.......................... 10 3 hsa-mir-124-3_R08 J1_ES_demeth ............................................................UUAAGGCACGCGGUGAAUGC.......................... 10 3 hsa-mir-124-3_R09 J1_ES_demeth .............................................................UAAGGCACGCGGUGAAUGC.......................... 8 3 hsa-mir-124-3_R10 ES_Dicer ..............................................................AAGGCACGCGGUGAAUGCCAA....................... 8 3 hsa-mir-124-3_R11 ES_Dicer ............................................................UUAAGGCACGCGGUGAAUGCCAA....................... 7 3 hsa-mir-124-3_R12 ES_Dicer .............................................................UAAGGCACGCGGUGAAUGCC......................... 6 3 hsa-mir-124-3_R13 ES_Dicer ............................................................UUAAGGCACGCGGUGAAUGCCAA....................... 5 3 hsa-mir-124-3_R14 J1_ES_untr ..............................................................AAGGCACGCGGUGAAUGCCAA....................... 5 3 hsa-mir-124-3_R15 J1_ES_demeth ............................................................UUAAGGCACGCGGUGAAUGC.......................... 4 3 hsa-mir-124-3_R16 ES_Dicer ............................................................UUAAGGCACGCGGUGAAUGCCA........................ 4 3 hsa-mir-124-3_R17 ES_Dicer ............................................................UUAAGGCACGCGGUGAAUGCCA........................ 4 3 hsa-mir-124-3_R18 J1_ES_demeth .............................................................UAAGGCACGCGGUGAAUG........................... 3 3 hsa-mir-124-3_R19 ES_Dicer .............................................................UAAGGCACGCGGUGAAUGC.......................... 3 3 hsa-mir-124-3_R20 J1_ES_untr ............................................................UUAAGGCACGCGGUGAAUGC.......................... 2 3 hsa-mir-124-3_R21 J1_ES_untr .............................................................UAAGGCACGCGGUGAAUGCCAAG...................... 2 3 hsa-mir-124-3_R22 J1_ES_demeth ..............................................................AAGGCACGCGGUGAAUGCCA........................ 2 3 hsa-mir-124-3_R23 J1_ES_demeth .............................................................UAAGGCACGCGGUGAAUGCC......................... 2 3 hsa-mir-124-3_R24 J1_ES_demeth ............................................................UUAAGGCACGCGGUGAAUGCC......................... 1 3 hsa-mir-124-3_R25 ES_Dicer ..............................................................AAGGCACGCGGUGAAUGCCA........................ 1 3 hsa-mir-124-3_R26 ES_Dicer .............................................................UAAGGCACGCGGUGAAUGCCAAG...................... 1 3 hsa-mir-124-3_R27 ES_Dicer .............................................................UAAGGCACGCGGUGAAUGCCAAGA..................... 1 3 hsa-mir-124-3_R28 J1_ES_untr ............................................................UUAAGGCACGCGGUGAAUG........................... 1 3 hsa-mir-124-3_R29 J1_ES_demeth ............................................................UUAAGGCACGCGGUGAAUGCC......................... 1 3 hsa-mir-124-3_R30 J1_ES_demeth hsa-mir-1248 chr3:187987135-187987280 + GAUUGUUAGACAUUAUUUUACCUUCUUGUAUAAGCACUGUGCUAAAAUUGCAGACACUAGGACCAUGUCUUGGUUUUUGCAAUAAUGCUAGCAGAGUACACACAAGAAGAAAAGUAACAGCACUAGAUUGUAA ((((........(((((((..((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).)))))))........)))).... (-36.69) ...................ACCUUCUUGUAUAAGCACUGUGCUAAA....................................................................................... 2 1 hsa-mir-1248_L01_M J1_ES_demeth ...................ACCUUCUUGUAUAAGCACUG.............................................................................................. 1 1 hsa-mir-1248_L02 ES_Dicer ...........................GUAUAAGCACUGUGCUAAA....................................................................................... 1 1 hsa-mir-1248_L03 ES_Dicer-DEL ......................UUCUUGUAUAAGCACUGUGC........................................................................................... 1 1 hsa-mir-1248_L04 ES_Dicer-DEL ...............................................................................................GUACACACAAGAAGAAAAG................... 1 1 hsa-mir-1248_R01*_M J1_ES_demeth hsa-mir-1249 chr22:43975479-43975584 - UGUUGGCAUGGGGAGGAGGGAGGAGAUGGGCCAAGUUCCCUCUGGCUGGAACGCCCUUCCCCCCCUUCUUCACCUGGCGAACUCC .(((.((..(((((((((((.((.((.((((...(((((........))))))))).)).))))))))))).))..)).)))... (-41.20) ..................................................ACGCCCUUCCCCCCCUUCUUCA............. 1 1 hsa-mir-1249_R01_M ES_Dicer ..................................................ACGCCCUUCCCCCCCUUCUUCA............. 1 1 hsa-mir-1249_R02 J1_ES_demeth hsa-mir-125a chr19:56888299-56888424 + ACACCAUGUUGCCAGUCUCUAGGUCCCUGAGACCCUUUAACCUGUGAGGACAUCCAGGGUCACAGGUGAGGUUCUUGGGAGCCUGGCGUCUGGCCCAACCACACA ..........(((((.(.(((((..((..(((.((((..((((((((((....))....)))))))))))).)))..))..))))).).)))))........... (-48.10) .......................UCCCUGAGACCCUUUAACCUGUGA.......................................................... 75 1 hsa-mir-125a_L01_M J1_ES_demeth .......................UCCCUGAGACCCUUUAACCUGU............................................................ 33 1 hsa-mir-125a_L02 J1_ES_demeth .......................UCCCUGAGACCCUUUAACCUGUGA.......................................................... 26 1 hsa-mir-125a_L03 J1_ES_untr .......................UCCCUGAGACCCUUUAACCUGUG........................................................... 19 1 hsa-mir-125a_L04 J1_ES_demeth .......................UCCCUGAGACCCUUUAACCUGUGA.......................................................... 9 1 hsa-mir-125a_L05 ES_Dicer .......................UCCCUGAGACCCUUUAACCUGUG........................................................... 9 1 hsa-mir-125a_L06 J1_ES_untr .......................UCCCUGAGACCCUUUAACCUGU............................................................ 5 1 hsa-mir-125a_L07 ES_Dicer .......................UCCCUGAGACCCUUUAACCUGU............................................................ 3 1 hsa-mir-125a_L08 J1_ES_untr .......................UCCCUGAGACCCUUUAACCUGUG........................................................... 2 1 hsa-mir-125a_L09 ES_Dicer ...........................UGAGACCCUUUAACCUGUGA.......................................................... 1 1 hsa-mir-125a_L10 J1_ES_demeth ...............................................................AGGUGAGGUUCUUGGGAGCC...................... 2 1 hsa-mir-125a_R01*_M J1_ES_demeth .............................................................ACAGGUGAGGUUCUUGGGAGCCU..................... 1 1 hsa-mir-125a_R02* J1_ES_demeth hsa-mir-125b-1 chr11:121475655-121475782 - AAAACAUUGUUGCGCUCCUCUCAGUCCCUGAGACCCUAACUUGUGAUGUUUACCGUUUAAAUCCACGGGUUAGGCUCUUGGGAGCUGCGAGUCGUGCUUUUGCAUCC .......(((.((((..(((.(((..((..(((.(((((((((((..(((((.....))))).))))))))))).)))..))..))).)))..))))....)))... (-44.50) ........................UCCCUGAGACCCUAACUUGUGA............................................................. 229 2 hsa-mir-125b-1_L01_M J1_ES_demeth ........................UCCCUGAGACCCUAACUUGUGA............................................................. 21 2 hsa-mir-125b-1_L02 J1_ES_untr ........................UCCCUGAGACCCUAACUUGUGA............................................................. 13 2 hsa-mir-125b-1_L03 ES_Dicer ........................UCCCUGAGACCCUAACUUGUG.............................................................. 7 2 hsa-mir-125b-1_L04 J1_ES_demeth ........................UCCCUGAGACCCUAACUUGUG.............................................................. 1 2 hsa-mir-125b-1_L05 ES_Dicer ........................UCCCUGAGACCCUAACUUGUGAU............................................................ 1 1 hsa-mir-125b-1_L06 J1_ES_demeth ...........................CUGAGACCCUAACUUGUGA............................................................. 1 2 hsa-mir-125b-1_L07 J1_ES_demeth .............................................................UCCACGGGUUAGGCUCUUGGGAG....................... 8 1 hsa-mir-125b-1_R01*_M J1_ES_demeth .............................................................UCCACGGGUUAGGCUCUUGGGA........................ 1 1 hsa-mir-125b-1_R02* J1_ES_demeth hsa-mir-125b-2 chr21:16884408-16884536 + CCGCAUCAAACCAGACUUUUCCUAGUCCCUGAGACCCUAACUUGUGAGGUAUUUUAGUAACAUCACAAGUCAGGCUCUUGGGACCUAGGCGGAGGGGAACCAGCAGCU ..((......((...(((..(((((..((..(((.(((.((((((((..(((....)))...)))))))).))).)))..))..)))))..))).)).....)).... (-41.30) .........................UCCCUGAGACCCUAACUUGUGA............................................................. 229 2 hsa-mir-125b-2_L01_M J1_ES_demeth .........................UCCCUGAGACCCUAACUUGUGA............................................................. 21 2 hsa-mir-125b-2_L02 J1_ES_untr .........................UCCCUGAGACCCUAACUUGUGA............................................................. 13 2 hsa-mir-125b-2_L03 ES_Dicer .........................UCCCUGAGACCCUAACUUGUG.............................................................. 7 2 hsa-mir-125b-2_L04 J1_ES_demeth .........................UCCCUGAGACCCUAACUUGUG.............................................................. 1 2 hsa-mir-125b-2_L05 ES_Dicer ............................CUGAGACCCUAACUUGUGA............................................................. 1 2 hsa-mir-125b-2_L06 J1_ES_demeth hsa-mir-126 chr9:138684855-138684979 + CCACGCCUCCGCUGGCGACGGGACAUUAUUACUUUUGGUACGCGCUGUGACACUUCAAACUCGUACCGUGAGUAAUAAUGCGCCGUCCACGGCACCGCAUCGAA ....((....((((..((((((.(((((((((((.(((((((.(...(((....)))..).))))))).)))))))))))).)))))..))))...))...... (-40.90) .......................CAUUAUUACUUUUGGUACGCG............................................................ 21 1 hsa-mir-126_L01*_M J1_ES_demeth .......................CAUUAUUACUUUUGGUACGCG............................................................ 20 1 hsa-mir-126_L02* J1_ES_untr .......................CAUUAUUACUUUUGGUACGCG............................................................ 8 1 hsa-mir-126_L03* ES_Dicer .......................CAUUAUUACUUUUGGUACG.............................................................. 2 1 hsa-mir-126_L04* ES_Dicer .......................CAUUAUUACUUUUGGUACGC............................................................. 2 1 hsa-mir-126_L05* J1_ES_demeth ........................AUUAUUACUUUUGGUACGCGC........................................................... 1 1 hsa-mir-126_L06* J1_ES_untr .......................CAUUAUUACUUUUGGUACGCGC........................................................... 1 1 hsa-mir-126_L07* J1_ES_demeth .......................CAUUAUUACUUUUGGUACG.............................................................. 1 1 hsa-mir-126_L08* J1_ES_demeth ............................................................UCGUACCGUGAGUAAUAAUGCG...................... 29 1 hsa-mir-126_R01_M J1_ES_untr ............................................................UCGUACCGUGAGUAAUAAUGCG...................... 19 1 hsa-mir-126_R02 J1_ES_demeth .............................................................CGUACCGUGAGUAAUAAUGCG...................... 11 1 hsa-mir-126_R03 J1_ES_demeth ............................................................UCGUACCGUGAGUAAUAAUGCG...................... 8 1 hsa-mir-126_R04 ES_Dicer .............................................................CGUACCGUGAGUAAUAAUGCG...................... 7 1 hsa-mir-126_R05 ES_Dicer .............................................................CGUACCGUGAGUAAUAAUGC....................... 4 1 hsa-mir-126_R06 ES_Dicer .............................................................CGUACCGUGAGUAAUAAUGCG...................... 4 1 hsa-mir-126_R07 J1_ES_untr ............................................................UCGUACCGUGAGUAAUAAUGC....................... 3 1 hsa-mir-126_R08 J1_ES_untr ............................................................UCGUACCGUGAGUAAUAAUGC....................... 3 1 hsa-mir-126_R09 J1_ES_demeth ............................................................UCGUACCGUGAGUAAUAAUG........................ 2 1 hsa-mir-126_R10 ES_Dicer ...........................................................CUCGUACCGUGAGUAAUAAUGCG...................... 2 1 hsa-mir-126_R11 ES_Dicer .............................................................CGUACCGUGAGUAAUAAUG........................ 2 1 hsa-mir-126_R12 ES_Dicer ...........................................................CUCGUACCGUGAGUAAUAAUGCG...................... 2 1 hsa-mir-126_R13 J1_ES_untr .............................................................CGUACCGUGAGUAAUAAUGC....................... 2 1 hsa-mir-126_R14 J1_ES_demeth .............................................................CGUACCGUGAGUAAUAAUGC....................... 1 1 hsa-mir-126_R15 J1_ES_untr hsa-mir-1264 chrX:113793366-113793474 + GCAUAUAGCAGGUCCUCAAUAAGUAUUUGUUGAAAGAAUAAAUAAACCAACAAGUCUUAUUUGAGCACCUGUUAUGUGGAGGAUACAA .((((((((((((.(((((((((.((((((((...............)))))))))))).))))).)))))))))))).......... (-32.56) .........AGGUCCUCAAUAAGUAUUUGUU......................................................... 1 1 hsa-mir-1264_L01_M J1_ES_untr hsa-mir-127 chr14:100419049-100419185 + AGGUCUCGCUGUGAUCACUGUCUCCAGCCUGCUGAAGCUCAGAGGGCUCUGAUUCAGAAAGAUCAUCGGAUCCGUCUGAGCUUGGCUGGUCGGAAGUCUCAUCAUCUGCUUCCUUC .((((.......)))).......((((((.....(((((((((.((.((((((((.....))..)))))).)).)))))))))))))))..((((((..........))))))... (-44.50) ...............................CUGAAGCUCAGAGGGCUCUGAU............................................................... 29 1 hsa-mir-127_L01*_M J1_ES_untr ...............................CUGAAGCUCAGAGGGCUCUGAU............................................................... 23 1 hsa-mir-127_L02* J1_ES_demeth ...............................CUGAAGCUCAGAGGGCUCUGAUU.............................................................. 15 1 hsa-mir-127_L03* J1_ES_demeth .................................GAAGCUCAGAGGGCUCUGAUUC............................................................. 13 1 hsa-mir-127_L04* J1_ES_untr ...............................CUGAAGCUCAGAGGGCUCUGAUU.............................................................. 13 1 hsa-mir-127_L05* J1_ES_untr .................................GAAGCUCAGAGGGCUCUGAUU.............................................................. 11 1 hsa-mir-127_L06* J1_ES_untr .................................GAAGCUCAGAGGGCUCUGAUUC............................................................. 6 1 hsa-mir-127_L07* J1_ES_demeth ...............................CUGAAGCUCAGAGGGCUCUGA................................................................ 6 1 hsa-mir-127_L08* J1_ES_untr ...............................CUGAAGCUCAGAGGGCUCUGA................................................................ 4 1 hsa-mir-127_L09* J1_ES_demeth .................................GAAGCUCAGAGGGCUCUGAUUCA............................................................ 4 1 hsa-mir-127_L10* J1_ES_untr ................................UGAAGCUCAGAGGGCUCUGAUU.............................................................. 3 1 hsa-mir-127_L11* J1_ES_untr ...............................CUGAAGCUCAGAGGGCUCUGAU............................................................... 2 1 hsa-mir-127_L12* ES_Dicer ...............................CUGAAGCUCAGAGGGCUCUGAUU.............................................................. 1 1 hsa-mir-127_L13* ES_Dicer .................................GAAGCUCAGAGGGCUCUGAUUCA............................................................ 1 1 hsa-mir-127_L14* ES_Dicer ................................UGAAGCUCAGAGGGCUCUGAUUC............................................................. 1 1 hsa-mir-127_L15* J1_ES_demeth .............................UGCUGAAGCUCAGAGGGCUCUGA................................................................ 1 1 hsa-mir-127_L16* J1_ES_demeth .................................GAAGCUCAGAGGGCUCUGAUU.............................................................. 1 1 hsa-mir-127_L17* J1_ES_demeth ................................UGAAGCUCAGAGGGCUCUGAU............................................................... 1 1 hsa-mir-127_L18* J1_ES_demeth .............................UGCUGAAGCUCAGAGGGCUCUGA................................................................ 1 1 hsa-mir-127_L19* J1_ES_untr .............................UGCUGAAGCUCAGAGGGCUCUGAU............................................................... 1 1 hsa-mir-127_L20* J1_ES_untr .................................................................UCGGAUCCGUCUGAGCUUGGCU............................. 321 1 hsa-mir-127_R01_M J1_ES_untr .................................................................UCGGAUCCGUCUGAGCUUGGCU............................. 171 1 hsa-mir-127_R02 J1_ES_demeth .................................................................UCGGAUCCGUCUGAGCUUGGCU............................. 44 1 hsa-mir-127_R03 ES_Dicer .................................................................UCGGAUCCGUCUGAGCUUGG............................... 36 1 hsa-mir-127_R04 J1_ES_untr .................................................................UCGGAUCCGUCUGAGCUUGG............................... 29 1 hsa-mir-127_R05 J1_ES_demeth .................................................................UCGGAUCCGUCUGAGCUUGG............................... 22 1 hsa-mir-127_R06 ES_Dicer .................................................................UCGGAUCCGUCUGAGCUUGGC.............................. 17 1 hsa-mir-127_R07 J1_ES_untr .................................................................UCGGAUCCGUCUGAGCUUGGC.............................. 7 1 hsa-mir-127_R08 ES_Dicer .................................................................UCGGAUCCGUCUGAGCUUGGC.............................. 6 1 hsa-mir-127_R09 J1_ES_demeth .................................................................UCGGAUCCGUCUGAGCUUG................................ 2 1 hsa-mir-127_R10 J1_ES_demeth .....................................................................AUCCGUCUGAGCUUGGCU............................. 2 1 hsa-mir-127_R11 J1_ES_demeth ..................................................................CGGAUCCGUCUGAGCUUGGCU............................. 2 1 hsa-mir-127_R12 J1_ES_untr ..................................................................CGGAUCCGUCUGAGCUUGGCU............................. 1 1 hsa-mir-127_R13 ES_Dicer .................................................................UCGGAUCCGUCUGAGCUUGG............................... 1 1 hsa-mir-127_R14 ES_Dicer-DEL hsa-mir-1274a chr5:41511471-41511581 + UUUGUCCCUGAUGUCCCUGUUUGUCCCUGUUCAGGCGCCACCUGUGGCUGUCUGCCACAAGUACUAUUUGAGACCAUCACUACGACAGUU .(((((..(((((((.(.....((.(.(((.(((((((((....)))).)))))..))).).)).....).)).)))))....))))).. (-23.80) .....................UGUCCCUGUUCAGGCGCCA.................................................. 5 1 hsa-mir-1274a_L01_M ES_Dicer-DEL ......................GUCCCUGUUCAGGCGCCA.................................................. 3 1 hsa-mir-1274a_L02 J1_ES_demeth .....................UGUCCCUGUUCAGGCGCCA.................................................. 1 1 hsa-mir-1274a_L03 ES_Dicer ......................GUCCCUGUUCAGGCGCCA.................................................. 1 1 hsa-mir-1274a_L04 ES_Dicer-DEL hsa-mir-1274b chr19:62716167-62716273 - UCCAGCAGACCUUCUUCACUCACGUCCCUGUUCGGGCGCCACUUGUGGCUGUCGGUUCGGGACUGAAUGAAGAAGGACAAAUGCAG ....(((..(((((((((.(((.(((((.(..(.(((((((....)))).))).)..))))))))).))))))))).....))).. (-40.40) .......................GUCCCUGUUCGGGCGCCA............................................. 26 1 hsa-mir-1274b_L01_M J1_ES_demeth .......................GUCCCUGUUCGGGCGCCA............................................. 10 1 hsa-mir-1274b_L02 ES_Dicer-DEL .......................GUCCCUGUUCGGGCGCCA............................................. 1 1 hsa-mir-1274b_L03 ES_Dicer ...................UCACGUCCCUGUUCGGGCGCCA............................................. 1 1 hsa-mir-1274b_L04 ES_Dicer-DEL hsa-mir-128-1 chr2:136139417-136139538 + CCUUGUUCCUGAGCUGUUGGAUUCGGGGCCGUAGCACUGUCUGAGAGGUUUACAUUUCUCACAGUGAACCGGUCUCUUUUUCAGCUGCUUCCUGGCUUCUU .......((.((((.((((((...(((((((...((((((..(((((((....)))))))))))))...)))))))...)))))).))))...))...... (-37.20) .......................CGGGGCCGUAGCACUGUCUGA......................................................... 1 1 hsa-mir-128-1_L01*_M ES_Dicer ..........................................................UCACAGUGAACCGGUCUCUUU...................... 197 2 hsa-mir-128-1_R01_M J1_ES_demeth ..........................................................UCACAGUGAACCGGUCUCUUU...................... 187 2 hsa-mir-128-1_R02 J1_ES_untr ..........................................................UCACAGUGAACCGGUCUCUUUU..................... 30 1 hsa-mir-128-1_R03 J1_ES_demeth ..........................................................UCACAGUGAACCGGUCUCUUUU..................... 14 1 hsa-mir-128-1_R04 J1_ES_untr ..........................................................UCACAGUGAACCGGUCUCUU....................... 14 2 hsa-mir-128-1_R05 J1_ES_demeth ..........................................................UCACAGUGAACCGGUCUCUU....................... 4 2 hsa-mir-128-1_R06 J1_ES_untr ..........................................................UCACAGUGAACCGGUCUCUUU...................... 3 2 hsa-mir-128-1_R07 ES_Dicer ..........................................................UCACAGUGAACCGGUCUCUU....................... 1 2 hsa-mir-128-1_R08 ES_Dicer hsa-mir-128-2 chr3:35760952-35761075 + CGGCAGCCACUGUGCAGUGGGAAGGGGGGCCGAUACACUGUACGAGAGUGAGUAGCAGGUCUCACAGUGAACCGGUCUCUUUCCCUACUGUGUCACACUCCUAA .((.((.....(..(((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).)))))))..)....))))... (-41.50) .............................................................UCACAGUGAACCGGUCUCUUU...................... 197 2 hsa-mir-128-2_R01_M J1_ES_demeth .............................................................UCACAGUGAACCGGUCUCUUU...................... 187 2 hsa-mir-128-2_R02 J1_ES_untr .............................................................UCACAGUGAACCGGUCUCUU....................... 14 2 hsa-mir-128-2_R03 J1_ES_demeth .............................................................UCACAGUGAACCGGUCUCUU....................... 4 2 hsa-mir-128-2_R04 J1_ES_untr .............................................................UCACAGUGAACCGGUCUCUUU...................... 3 2 hsa-mir-128-2_R05 ES_Dicer .............................................................UCACAGUGAACCGGUCUCUU....................... 1 2 hsa-mir-128-2_R06 ES_Dicer hsa-mir-129-1 chr7:127635141-127635252 + GUCUCCUUUGGAUCUUUUUGCGGUCUGGGCUUGCUGUUCCUCUCAACAGUAGUCAGGAAGCCCUUACCCCAAAAAGUAUCUGCGGGAGGCCU (((((((.((((((((((((.(((..((((((.(((..(..((....))..).))).))))))..))).))))))).))))).))))))).. (-42.60) .............CUUUUUGCGGUCUGGGCUUGC.......................................................... 3 2 hsa-mir-129-1_L01_M J1_ES_untr ............UCUUUUUGCGGUCUGGGCUUGC.......................................................... 2 2 hsa-mir-129-1_L02 J1_ES_untr .............CUUUUUGCGGUCUGGGCUUGC.......................................................... 2 2 hsa-mir-129-1_L03 J1_ES_demeth .............CUUUUUGCGGUCUGGGCUUGC.......................................................... 1 2 hsa-mir-129-1_L04 ES_Dicer .............CUUUUUGCGGUCUGGGCUUG........................................................... 1 2 hsa-mir-129-1_L05 J1_ES_demeth .........................................................AAGCCCUUACCCCAAAAAGUAU............. 2 1 hsa-mir-129-1_R01*_M J1_ES_demeth .........................................................AAGCCCUUACCCCAAAAAG................ 1 2 hsa-mir-129-1_R02* J1_ES_demeth hsa-mir-129-2 chr11:43559500-43559629 + GGCAUAUUCUGCCCUUCGCGAAUCUUUUUGCGGUCUGGGCUUGCUGUACAUAACUCAAUAGCCGGAAGCCCUUACCCCAAAAAGCAUUUGCGGAGGGCGCACUCGUCGA (((......(((((((((((((((((((((.(((..(((((((((((..........)))))...))))))..))).))))))).)))))))))))))).....))).. (-50.40) .......................CUUUUUGCGGUCUGGGCUUGC................................................................. 3 2 hsa-mir-129-2_L01*_M J1_ES_untr ......................UCUUUUUGCGGUCUGGGCUUGC................................................................. 2 2 hsa-mir-129-2_L02* J1_ES_untr .......................CUUUUUGCGGUCUGGGCUUGC................................................................. 2 2 hsa-mir-129-2_L03* J1_ES_demeth .......................CUUUUUGCGGUCUGGGCUUGC................................................................. 1 2 hsa-mir-129-2_L04* ES_Dicer .......................CUUUUUGCGGUCUGGGCUUG.................................................................. 1 2 hsa-mir-129-2_L05* J1_ES_demeth .................................................................AAGCCCUUACCCCAAAAAGCAU...................... 36 1 hsa-mir-129-2_R01_M J1_ES_demeth .................................................................AAGCCCUUACCCCAAAAAGCAU...................... 21 1 hsa-mir-129-2_R02 J1_ES_untr .................................................................AAGCCCUUACCCCAAAAAGCA....................... 2 1 hsa-mir-129-2_R03 J1_ES_demeth .................................................................AAGCCCUUACCCCAAAAAG......................... 1 2 hsa-mir-129-2_R04 J1_ES_demeth ..................................................................AGCCCUUACCCCAAAAAGCAUU..................... 1 1 hsa-mir-129-2_R05 J1_ES_demeth hsa-mir-1306 chr22:18453561-18453685 + CGCUGCCCCGUGAGCAGUCUCCACCACCUCCCCUGCAAACGUCCAGUGGUGCAGAGGUAAUGGACGUUGGCUCUGGUGGUGAUGGACAGUCCGAACUCCCUGCU .(((((.......))))).((((.((((.((...((.((((((((....(((....))).)))))))).))...)).)))).)))).................. (-36.30) .......................CCACCUCCCCUGCAAACGUCCA........................................................... 1 1 hsa-mir-1306_L01*_M J1_ES_untr ..............................................................GACGUUGGCUCUGGUGGUGAU..................... 2 1 hsa-mir-1306_R01_M J1_ES_demeth ..............................................................GACGUUGGCUCUGGUGGUGAU..................... 1 1 hsa-mir-1306_R02 J1_ES_untr hsa-mir-130a chr11:57165227-57165355 + GCAUGCCUCUGCUGCUGGCCAGAGCUCUUUUCACAUUGUGCUACUGUCUGCACCUGUCACUAGCAGUGCAAUGUUAAAAGGGCAUUGGCCGUGUAGUGCUACCCAGCG ((.((.....((((((((((((.((((((((.((((((..((.(((...((....))...))).))..)))))).)))))))).))))))).)))))......)))). (-43.90) .......................GCUCUUUUCACAUUGUGCUACU............................................................... 39 1 hsa-mir-130a_L01*_M J1_ES_demeth .......................GCUCUUUUCACAUUGUGCUACU............................................................... 16 1 hsa-mir-130a_L02* J1_ES_untr .......................GCUCUUUUCACAUUGUGCUACU............................................................... 6 1 hsa-mir-130a_L03* ES_Dicer .......................GCUCUUUUCACAUUGUGCUAC................................................................ 4 1 hsa-mir-130a_L04* J1_ES_demeth .....................GAGCUCUUUUCACAUUGUGCUACU............................................................... 1 1 hsa-mir-130a_L05* J1_ES_demeth ...............................................................CAGUGCAAUGUUAAAAGGGCAU....................... 1571 1 hsa-mir-130a_R01_M J1_ES_demeth ...............................................................CAGUGCAAUGUUAAAAGGGCAU....................... 1003 1 hsa-mir-130a_R02 J1_ES_untr ...............................................................CAGUGCAAUGUUAAAAGGGCAUU...................... 155 1 hsa-mir-130a_R03 J1_ES_demeth ...............................................................CAGUGCAAUGUUAAAAGGGCAU....................... 120 1 hsa-mir-130a_R04 ES_Dicer ...............................................................CAGUGCAAUGUUAAAAGGGCAUU...................... 98 1 hsa-mir-130a_R05 J1_ES_untr ...............................................................CAGUGCAAUGUUAAAAGGGC......................... 51 1 hsa-mir-130a_R06 ES_Dicer ...............................................................CAGUGCAAUGUUAAAAGGG.......................... 42 1 hsa-mir-130a_R07 ES_Dicer ...............................................................CAGUGCAAUGUUAAAAGGGCA........................ 30 1 hsa-mir-130a_R08 J1_ES_demeth ...............................................................CAGUGCAAUGUUAAAAGGGCA........................ 27 1 hsa-mir-130a_R09 J1_ES_untr ...............................................................CAGUGCAAUGUUAAAAGGGCAUU...................... 22 1 hsa-mir-130a_R10 ES_Dicer ................................................................AGUGCAAUGUUAAAAGGGCAU....................... 14 1 hsa-mir-130a_R11 J1_ES_demeth ...............................................................CAGUGCAAUGUUAAAAGGGC......................... 5 1 hsa-mir-130a_R12 J1_ES_demeth ..............................................................GCAGUGCAAUGUUAAAAGGGCAU....................... 3 1 hsa-mir-130a_R13 J1_ES_demeth ...............................................................CAGUGCAAUGUUAAAAGGGCA........................ 2 1 hsa-mir-130a_R14 ES_Dicer ................................................................AGUGCAAUGUUAAAAGGGCAU....................... 2 1 hsa-mir-130a_R15 J1_ES_untr ...............................................................CAGUGCAAUGUUAAAAGGGC......................... 2 1 hsa-mir-130a_R16 J1_ES_untr ...............................................................CAGUGCAAUGUUAAAAGGG.......................... 2 1 hsa-mir-130a_R17 J1_ES_demeth ................................................................AGUGCAAUGUUAAAAGGGCAUU...................... 2 1 hsa-mir-130a_R18 J1_ES_demeth ..................................................................UGCAAUGUUAAAAGGGCAU....................... 2 1 hsa-mir-130a_R19 J1_ES_demeth ................................................................AGUGCAAUGUUAAAAGGGCAU....................... 1 1 hsa-mir-130a_R20 ES_Dicer ..............................................................GCAGUGCAAUGUUAAAAGGGC......................... 1 1 hsa-mir-130a_R21 ES_Dicer ..............................................................GCAGUGCAAUGUUAAAAGGGCAU....................... 1 1 hsa-mir-130a_R22 J1_ES_untr ................................................................AGUGCAAUGUUAAAAGGGCAUU...................... 1 1 hsa-mir-130a_R23 J1_ES_untr ..................................................................UGCAAUGUUAAAAGGGCAUU...................... 1 1 hsa-mir-130a_R24 J1_ES_demeth hsa-mir-130b chr22:20337573-20337694 + GCACUGGCAGGCCUGCCCGACACUCUUUCCCUGUUGCACUACUAUAGGCCGCUGGGAAGCAGUGCAAUGAUGAAAGGGCAUCGGUCAGGUCCAGCCUGCUACCCUGGGAG (((..(((.((((((.((((..(((((((..(((((((((.((.(((....)))...)).)))))))))..)))))))..)))).))))))..))))))........... (-44.40) .....................ACUCUUUCCCUGUUGCACUACU................................................................... 48 1 hsa-mir-130b_L01*_M J1_ES_untr .....................ACUCUUUCCCUGUUGCACUACU................................................................... 32 1 hsa-mir-130b_L02* J1_ES_demeth .....................ACUCUUUCCCUGUUGCACUACU................................................................... 13 1 hsa-mir-130b_L03* ES_Dicer .....................ACUCUUUCCCUGUUGCACUAC.................................................................... 3 1 hsa-mir-130b_L04* J1_ES_demeth .....................ACUCUUUCCCUGUUGCACUAC.................................................................... 2 1 hsa-mir-130b_L05* J1_ES_untr .....................ACUCUUUCCCUGUUGCACUAC.................................................................... 1 1 hsa-mir-130b_L06* ES_Dicer .....................ACUCUUUCCCUGUUGCACUA..................................................................... 1 1 hsa-mir-130b_L07* ES_Dicer ....................CACUCUUUCCCUGUUGCACUAC.................................................................... 1 1 hsa-mir-130b_L08* J1_ES_untr .......................UCUUUCCCUGUUGCACUACU................................................................... 1 1 hsa-mir-130b_L09* J1_ES_demeth ...........................................................CAGUGCAAUGAUGAAAGGGCAU............................. 271 1 hsa-mir-130b_R01_M J1_ES_untr ...........................................................CAGUGCAAUGAUGAAAGGGCAU............................. 134 1 hsa-mir-130b_R02 J1_ES_demeth ...........................................................CAGUGCAAUGAUGAAAGGGCAU............................. 21 1 hsa-mir-130b_R03 ES_Dicer ...........................................................CAGUGCAAUGAUGAAAGGGC............................... 15 1 hsa-mir-130b_R04 ES_Dicer ...........................................................CAGUGCAAUGAUGAAAGGGCA.............................. 13 1 hsa-mir-130b_R05 J1_ES_untr ...........................................................CAGUGCAAUGAUGAAAGGG................................ 8 1 hsa-mir-130b_R06 ES_Dicer ............................................................AGUGCAAUGAUGAAAGGGCAU............................. 6 1 hsa-mir-130b_R07 J1_ES_demeth ............................................................AGUGCAAUGAUGAAAGGGCAU............................. 4 1 hsa-mir-130b_R08 J1_ES_untr ..............................................................UGCAAUGAUGAAAGGGCAU............................. 4 1 hsa-mir-130b_R09 J1_ES_untr ...........................................................CAGUGCAAUGAUGAAAGGGCA.............................. 4 1 hsa-mir-130b_R10 J1_ES_demeth ............................................................AGUGCAAUGAUGAAAGGGCAU............................. 2 1 hsa-mir-130b_R11 ES_Dicer .............................................................GUGCAAUGAUGAAAGGGCAU............................. 1 1 hsa-mir-130b_R12 ES_Dicer ...........................................................CAGUGCAAUGAUGAAAGGGCAUC............................ 1 1 hsa-mir-130b_R13 J1_ES_untr .............................................................GUGCAAUGAUGAAAGGGCAU............................. 1 1 hsa-mir-130b_R14 J1_ES_demeth hsa-mir-132 chr17:1899932-1900072 - CGCCGUCCGCGCGCCCCGCCCCCGCGUCUCCAGGGCAACCGUGGCUUUCGAUUGUUACUGUGGGAACUGGAGGUAACAGUCUACAGCCAUGGUCGCCCCGCAGCACGCCCACGCGCCGCGCCACGCCGCGCCC (((.((..(((((...(((....((((((.(.((((.(((((((((...((((((((((..(....)....))))))))))...))))))))).)))).).)).))))....))).)))))...)).)))... (-61.90) .........................................................................UAACAGUCUACAGCCAUGGUCG...................................... 13 1 hsa-mir-132_R01_M J1_ES_demeth .........................................................................UAACAGUCUACAGCCAUGGUCG...................................... 6 1 hsa-mir-132_R02 J1_ES_untr .........................................................................UAACAGUCUACAGCCAUGGUC....................................... 1 1 hsa-mir-132_R03 J1_ES_demeth hsa-mir-133a-1 chr18:17659637-17659764 - UAGCAGCACUACAAUGCUUUGCUAGAGCUGGUAAAAUGGAACCAAAUCGCCUCUUCAAUGGAUUUGGUCCCCUUCAACCAGCUGUAGCUAUGCAUUGAUUACUACGG ...........((((((...((((.(((((((..((.((.((((((((............)))))))).)).))..))))))).))))...)))))).......... (-40.50) ..........................GCUGGUAAAAUGGAACCAAAU............................................................ 1 2 hsa-mir-133a-1_L01*_M J1_ES_demeth ..............................................................UUUGGUCCCCUUCAACCAGCUGU...................... 3 2 hsa-mir-133a-1_R01_M J1_ES_demeth ..............................................................UUUGGUCCCCUUCAACCAGCUG....................... 3 2 hsa-mir-133a-1_R02 J1_ES_untr ...............................................................UUGGUCCCCUUCAACCAGCUG....................... 1 2 hsa-mir-133a-1_R03 J1_ES_demeth ...............................................................UUGGUCCCCUUCAACCAGCUGU...................... 1 2 hsa-mir-133a-1_R04 J1_ES_demeth ..............................................................UUUGGUCCCCUUCAACCAGCUG....................... 1 2 hsa-mir-133a-1_R05 J1_ES_demeth hsa-mir-133a-2 chr20:60572544-60572685 + CUCGGAUCUGGGAGCCAAAUGCUUUGCUAGAGCUGGUAAAAUGGAACCAAAUCGACUGUCCAAUGGAUUUGGUCCCCUUCAACCAGCUGUAGCUGUGCAUUGAUGGCGCCGUGCGGCCCGGCCG ..(((..(((((.(((((((((...((((.(((((((..((.((.((((((((.(........).)))))))).)).))..))))))).))))...)))))..)))).((....)))))))))) (-53.40) ...............................GCUGGUAAAAUGGAACCAAAU........................................................................ 1 2 hsa-mir-133a-2_L01*_M J1_ES_demeth ...................................................................UUUGGUCCCCUUCAACCAGCUGU.................................. 3 2 hsa-mir-133a-2_R01_M J1_ES_demeth ...................................................................UUUGGUCCCCUUCAACCAGCUG................................... 3 2 hsa-mir-133a-2_R02 J1_ES_untr ....................................................................UUGGUCCCCUUCAACCAGCUG................................... 1 2 hsa-mir-133a-2_R03 J1_ES_demeth ....................................................................UUGGUCCCCUUCAACCAGCUGU.................................. 1 2 hsa-mir-133a-2_R04 J1_ES_demeth ...................................................................UUUGGUCCCCUUCAACCAGCUG................................... 1 2 hsa-mir-133a-2_R05 J1_ES_demeth hsa-mir-134 chr14:100590757-100590869 + AGCACCGUCCAGGGUGUGUGACUGGUUGACCAGAGGGGCAUGCACUGUGUUCACCCUGUGGGCCACCUAGUCACCAACCCUCAGCAUCACUCCCA ......((..(((((..((((((((.((.(((.((((((((.....))))...)))).)))..)).))))))))..)))))..)).......... (-37.50) ................UGUGACUGGUUGACCAGAGGGG......................................................... 25 1 hsa-mir-134_L01_M J1_ES_untr ................UGUGACUGGUUGACCAGAGGG.......................................................... 17 1 hsa-mir-134_L02 J1_ES_untr ................UGUGACUGGUUGACCAGAGGG.......................................................... 14 1 hsa-mir-134_L03 J1_ES_demeth ................UGUGACUGGUUGACCAGAGGGG......................................................... 12 1 hsa-mir-134_L04 J1_ES_demeth ................UGUGACUGGUUGACCAGAGGG.......................................................... 1 1 hsa-mir-134_L05 ES_Dicer ...............GUGUGACUGGUUGACCAGAGGG.......................................................... 1 1 hsa-mir-134_L06 J1_ES_demeth ................UGUGACUGGUUGACCAGAG............................................................ 1 1 hsa-mir-134_L07 J1_ES_demeth .......................................................CUGUGGGCCACCUAGUCACCA................... 1 1 hsa-mir-134_R01*_M J1_ES_demeth hsa-mir-135b chr1:203684033-203684169 - UGGACCCCUCCACUCUGCUGUGGCCUAUGGCUUUUCAUUCCUAUGUGAUUGCUGUCCCAAACUCAUGUAGGGCUAAAAGCCAUGGGCUACAGUGAGGGGCGAGCUCCUUCUCCUGC .(((((((((......(((((((((((((((((((...(((((((((((((......)))..))))))))))..))))))))))))))))))))))))).....)))......... (-54.40) .........................UAUGGCUUUUCAUUCCUAUGUGA.................................................................... 88 1 hsa-mir-135b_L01_M J1_ES_demeth .........................UAUGGCUUUUCAUUCCUAUGUGA.................................................................... 62 1 hsa-mir-135b_L02 J1_ES_untr .........................UAUGGCUUUUCAUUCCUAUGUG..................................................................... 25 1 hsa-mir-135b_L03 J1_ES_demeth .........................UAUGGCUUUUCAUUCCUAUGUG..................................................................... 14 1 hsa-mir-135b_L04 J1_ES_untr .........................UAUGGCUUUUCAUUCCUAUGUGA.................................................................... 10 1 hsa-mir-135b_L05 ES_Dicer .........................UAUGGCUUUUCAUUCCUAUGU...................................................................... 4 1 hsa-mir-135b_L06 ES_Dicer .........................UAUGGCUUUUCAUUCCUAUGU...................................................................... 3 1 hsa-mir-135b_L07 J1_ES_demeth .........................UAUGGCUUUUCAUUCCUAUGU...................................................................... 2 1 hsa-mir-135b_L08 J1_ES_untr ..............................CUUUUCAUUCCUAUGUGA.................................................................... 2 1 hsa-mir-135b_L09 J1_ES_demeth .........................UAUGGCUUUUCAUUCCUAUGUG..................................................................... 1 1 hsa-mir-135b_L10 ES_Dicer hsa-mir-136 chr14:100420772-100420893 + GGUGUUGGAUGAGCCCUCGGAGGACUCCAUUUGUUUUGAUGAUGGAUUCUUAUGCUCCAUCAUCGUCUCAAAUGAGUCUUCAGAGGGUUCUAUCAUUUCGU .......(((((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).)))....... (-48.10) .......................ACUCCAUUUGUUUUGAUGAUGGA....................................................... 26 1 hsa-mir-136_L01_M J1_ES_demeth .......................ACUCCAUUUGUUUUGAUGAUGGA....................................................... 23 1 hsa-mir-136_L02 J1_ES_untr .......................ACUCCAUUUGUUUUGAUGAUGGA....................................................... 12 1 hsa-mir-136_L03 ES_Dicer .......................ACUCCAUUUGUUUUGAUGAUGG........................................................ 8 1 hsa-mir-136_L04 ES_Dicer .......................ACUCCAUUUGUUUUGAUGAUG......................................................... 2 1 hsa-mir-136_L05 ES_Dicer .......................ACUCCAUUUGUUUUGAUGAU.......................................................... 2 1 hsa-mir-136_L06 ES_Dicer .......................ACUCCAUUUGUUUUGAUGAUG......................................................... 2 1 hsa-mir-136_L07 J1_ES_demeth .......................ACUCCAUUUGUUUUGAUGAU.......................................................... 2 1 hsa-mir-136_L08 J1_ES_demeth .......................ACUCCAUUUGUUUUGAUGAUGG........................................................ 2 1 hsa-mir-136_L09 J1_ES_demeth .......................ACUCCAUUUGUUUUGAUGAUGG........................................................ 2 1 hsa-mir-136_L10 J1_ES_untr ...................GAGGACUCCAUUUGUUUUGAUGAUGGA....................................................... 2 1 hsa-mir-136_L11 J1_ES_untr ........................CUCCAUUUGUUUUGAUGAUGG........................................................ 1 1 hsa-mir-136_L12 ES_Dicer ........................CUCCAUUUGUUUUGAUGAUGGA....................................................... 1 1 hsa-mir-136_L13 J1_ES_demeth .......................ACUCCAUUUGUUUUGAUGAUGGAU...................................................... 1 1 hsa-mir-136_L14 J1_ES_demeth .......................ACUCCAUUUGUUUUGAUGAUG......................................................... 1 1 hsa-mir-136_L15 J1_ES_untr ..UGUUGGAUGAGCCCUCGGA................................................................................ 1 1 hsa-mir-136_L16 ES_Dicer-DEL .GUGUUGGAUGAGCCCUCGGA................................................................................ 1 1 hsa-mir-136_L17 ES_Dicer-DEL .........................................................CAUCAUCGUCUCAAAUGAGUCU...................... 15 1 hsa-mir-136_R01*_M J1_ES_untr ..........................................................AUCAUCGUCUCAAAUGAGUCU...................... 13 1 hsa-mir-136_R02* ES_Dicer ..........................................................AUCAUCGUCUCAAAUGAGUCU...................... 11 1 hsa-mir-136_R03* J1_ES_untr ..........................................................AUCAUCGUCUCAAAUGAGUCU...................... 9 1 hsa-mir-136_R04* J1_ES_demeth .........................................................CAUCAUCGUCUCAAAUGAGUCU...................... 8 1 hsa-mir-136_R05* J1_ES_demeth ...........................................................UCAUCGUCUCAAAUGAGUCUU..................... 8 1 hsa-mir-136_R06* J1_ES_demeth .........................................................CAUCAUCGUCUCAAAUGAGUCU...................... 6 1 hsa-mir-136_R07* ES_Dicer ...........................................................UCAUCGUCUCAAAUGAGUCUU..................... 6 1 hsa-mir-136_R08* J1_ES_untr ...........................................................UCAUCGUCUCAAAUGAGUCUUC.................... 2 1 hsa-mir-136_R09* J1_ES_untr .........................................................CAUCAUCGUCUCAAAUGAGUC....................... 2 1 hsa-mir-136_R10* J1_ES_untr .........................................................CAUCAUCGUCUCAAAUGAGUC....................... 1 1 hsa-mir-136_R11* ES_Dicer ............................................................CAUCGUCUCAAAUGAGUCUUC.................... 1 1 hsa-mir-136_R12* J1_ES_demeth ...........................................................UCAUCGUCUCAAAUGAGUCU...................... 1 1 hsa-mir-136_R13* J1_ES_demeth ............................................................CAUCGUCUCAAAUGAGUCUU..................... 1 1 hsa-mir-136_R14* J1_ES_demeth ..........................................................AUCAUCGUCUCAAAUGAGUC....................... 1 1 hsa-mir-136_R15* J1_ES_untr ............................................................CAUCGUCUCAAAUGAGUCUUC.................... 1 1 hsa-mir-136_R16* J1_ES_untr hsa-mir-137 chr1:98284194-98284335 - GCGGCAGCUUGGUCCUCUGACUCUCUUCGGUGACGGGUAUUCUUGGGUGGAUAAUACGGAUUACGUUGUUAUUGCUUAAGAAUACGCGUAGUCGAGGAGAGUACCAGCGGCAGGGGGGCAG ((....)).((.((((((((((((((((((..(((.(((((((((((..(.(((((((.....)).))))))..))))))))))).)))..)))))))))))........))))))).)). (-55.60) ....................................................................UUAUUGCUUAAGAAUACGCGUAG.............................. 1 1 hsa-mir-137_R01_M J1_ES_demeth hsa-mir-138-1 chr3:44130688-44130826 + CAGAGACCUCCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGGCAGCAUUCCAG ..(((..((.((((...((((((((((.(((..(((((((((((((...(((((((..(.....)..)))))))..))))))))))))).))).)))))))))))))).))..)))... (-61.00) ...............................AGCUGGUGUUGUGAAUCAGGCCG................................................................. 14 2 hsa-mir-138-1_L01_M J1_ES_demeth ...............................AGCUGGUGUUGUGAAUCAGGCCGU................................................................ 12 1 hsa-mir-138-1_L02 J1_ES_demeth ...............................AGCUGGUGUUGUGAAUCAGGCC.................................................................. 5 2 hsa-mir-138-1_L03 J1_ES_demeth ...............................AGCUGGUGUUGUGAAUCAGGCCGUU............................................................... 4 1 hsa-mir-138-1_L04 J1_ES_demeth ...............................AGCUGGUGUUGUGAAUCAGGC................................................................... 4 2 hsa-mir-138-1_L05 J1_ES_demeth ...............................AGCUGGUGUUGUGAAUCAGGCCGU................................................................ 2 1 hsa-mir-138-1_L06 J1_ES_untr ...............................AGCUGGUGUUGUGAAUCAGGCCG................................................................. 1 2 hsa-mir-138-1_L07 ES_Dicer ...............................AGCUGGUGUUGUGAAUCAGGC................................................................... 1 2 hsa-mir-138-1_L08 J1_ES_untr ...............................AGCUGGUGUUGUGAAUCAGGCCGUU............................................................... 1 1 hsa-mir-138-1_L09 J1_ES_untr hsa-mir-138-2 chr16:55449911-55450034 + GCGGAGUUCUGGUAUCGUUGCUGCAGCUGGUGUUGUGAAUCAGGCCGACGAGCAGCGCAUCCUCUUACCCGGCUAUUUCACGACACCAGGGUUGCAUCAUACCCAUCCUCUC ..((((....(((((.(.(((.((..(((((((((((((...(((((..(((.((......)))))...)))))..))))))))))))).)).))).))))))....)))). (-44.40) ........................AGCUGGUGUUGUGAAUCAGGCCG................................................................. 14 2 hsa-mir-138-2_L01_M J1_ES_demeth ........................AGCUGGUGUUGUGAAUCAGGCC.................................................................. 5 2 hsa-mir-138-2_L02 J1_ES_demeth ........................AGCUGGUGUUGUGAAUCAGGC................................................................... 4 2 hsa-mir-138-2_L03 J1_ES_demeth ........................AGCUGGUGUUGUGAAUCAGGCCGA................................................................ 2 1 hsa-mir-138-2_L04 J1_ES_demeth ........................AGCUGGUGUUGUGAAUCAGGCCG................................................................. 1 2 hsa-mir-138-2_L05 ES_Dicer ........................AGCUGGUGUUGUGAAUCAGGC................................................................... 1 2 hsa-mir-138-2_L06 J1_ES_untr hsa-mir-139 chr11:72003735-72003842 - CUGGGACUGGCUCAGGUGUAUUCUACAGUGCACGUGUCUCCAGUGUGGCUCGGAGGCUGGAGACGCGGCCCUGUUGGAGUAACAACUGAAGC .........((((((.((((((((((((.((.((((((((((((.(.......).)))))))))))))).))).)))))).))).))).))) (-42.10) .....................UCUACAGUGCACGUGUCUCCAGU................................................ 1 1 hsa-mir-139_L01_M ES_Dicer .....................UCUACAGUGCACGUGUCUCCAGU................................................ 1 1 hsa-mir-139_L02 J1_ES_demeth hsa-mir-140 chr16:68524465-68524604 + CCGCGCCCUGUGUGUGUCUCUCUCUGUGUCCUGCCAGUGGUUUUACCCUAUGGUAGGUUACGUCAUGCUGUUCUACCACAGGGUAGAACCACGGACAGGAUACCGGGGCACCCUCUGCGUCG ..((((...(.(.(((((((.....((((((((((.(((((((((((((.(((((((..(((......)))))))))).))))))))))))))).)))))))).))))))).).).)))).. (-60.20) ..................................CAGUGGUUUUACCCUAUGGUAG.................................................................. 27 1 hsa-mir-140_L01_M J1_ES_demeth ..................................CAGUGGUUUUACCCUAUGGUAG.................................................................. 22 1 hsa-mir-140_L02 J1_ES_untr ..................................CAGUGGUUUUACCCUAUGGUAG.................................................................. 19 1 hsa-mir-140_L03 ES_Dicer ..................................CAGUGGUUUUACCCUAUGGU.................................................................... 1 1 hsa-mir-140_L04 J1_ES_demeth ..................................CAGUGGUUUUACCCUAUGGUA................................................................... 1 1 hsa-mir-140_L05 J1_ES_untr ..........................................................................ACCACAGGGUAGAACCACGGAC.......................... 13 1 hsa-mir-140_R01*_M ES_Dicer ..........................................................................ACCACAGGGUAGAACCACGGAC.......................... 12 1 hsa-mir-140_R02* J1_ES_demeth .........................................................................UACCACAGGGUAGAACCACGGAC.......................... 12 1 hsa-mir-140_R03* J1_ES_untr ..........................................................................ACCACAGGGUAGAACCACGGACA......................... 9 1 hsa-mir-140_R04* J1_ES_demeth .........................................................................UACCACAGGGUAGAACCACGGAC.......................... 9 1 hsa-mir-140_R05* J1_ES_demeth ..........................................................................ACCACAGGGUAGAACCACGGAC.......................... 7 1 hsa-mir-140_R06* J1_ES_untr .........................................................................UACCACAGGGUAGAACCACGGACA......................... 7 1 hsa-mir-140_R07* J1_ES_untr ..........................................................................ACCACAGGGUAGAACCACGGA........................... 5 1 hsa-mir-140_R08* ES_Dicer .........................................................................UACCACAGGGUAGAACCACGGACA......................... 4 1 hsa-mir-140_R09* J1_ES_demeth ..........................................................................ACCACAGGGUAGAACCACGG............................ 2 1 hsa-mir-140_R10* ES_Dicer ..........................................................................ACCACAGGGUAGAACCACGGA........................... 2 1 hsa-mir-140_R11* J1_ES_demeth ..........................................................................ACCACAGGGUAGAACCACGGACA......................... 2 1 hsa-mir-140_R12* J1_ES_untr ..........................................................................ACCACAGGGUAGAACCACGGA........................... 2 1 hsa-mir-140_R13* J1_ES_untr .........................................................................UACCACAGGGUAGAACCACGGAC.......................... 1 1 hsa-mir-140_R14* ES_Dicer ...........................................................................CCACAGGGUAGAACCACGGACA......................... 1 1 hsa-mir-140_R15* ES_Dicer ...........................................................................CCACAGGGUAGAACCACGGAC.......................... 1 1 hsa-mir-140_R16* ES_Dicer .........................................................................UACCACAGGGUAGAACCACGGA........................... 1 1 hsa-mir-140_R17* ES_Dicer .......................................................................UCUACCACAGGGUAGAACCACGGAC.......................... 1 1 hsa-mir-140_R18* ES_Dicer-DEL hsa-mir-141 chr12:6943501-6943635 + AGUUCUCUGUCGGCCGGCCCUGGGUCCAUCUUCCAGUACAGUGUUGGAUGGUCUAAUUGUGAAGCUCCUAACACUGUCUGGUAAAGAUGGCUCCCGGGUGGGUUCUCUCGGCAGU ......(((((((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).))).....)))))). (-55.30) ....................................................................UAACACUGUCUGGUAAAGAUG.......................... 41 1 hsa-mir-141_R01_M ES_Dicer ....................................................................UAACACUGUCUGGUAAAGAUGGC........................ 11 1 hsa-mir-141_R02 J1_ES_demeth ....................................................................UAACACUGUCUGGUAAAGAUGGC........................ 9 1 hsa-mir-141_R03 J1_ES_untr ....................................................................UAACACUGUCUGGUAAAGAUGG......................... 9 1 hsa-mir-141_R04 J1_ES_demeth ....................................................................UAACACUGUCUGGUAAAGAUGG......................... 8 1 hsa-mir-141_R05 ES_Dicer ....................................................................UAACACUGUCUGGUAAAGAUG.......................... 8 1 hsa-mir-141_R06 J1_ES_demeth ....................................................................UAACACUGUCUGGUAAAGAUGG......................... 7 1 hsa-mir-141_R07 J1_ES_untr ....................................................................UAACACUGUCUGGUAAAGAUGGC........................ 6 1 hsa-mir-141_R08 ES_Dicer ....................................................................UAACACUGUCUGGUAAAGAU........................... 3 1 hsa-mir-141_R09 J1_ES_demeth ....................................................................UAACACUGUCUGGUAAAGAU........................... 2 1 hsa-mir-141_R10 J1_ES_untr ...................................................................CUAACACUGUCUGGUAAAGAUG.......................... 1 1 hsa-mir-141_R11 ES_Dicer ....................................................................UAACACUGUCUGGUAAAGAUGGCU....................... 1 1 hsa-mir-141_R12 ES_Dicer hsa-mir-142 chr17:53763572-53763698 - CGGACAGACAGACAGUGCAGUCACCCAUAAAGUAGAAAGCACUACUAACAGCACUGGAGGGUGUAGUGUUUCCUACUUUAUGGAUGAGUGUACUGUGGGCUUCGGA (.((.((.(..((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).))))))))..))))).). (-47.40) .......................CCCAUAAAGUAGAAAGCACUAC............................................................. 23 1 hsa-mir-142_L01*_M J1_ES_demeth .......................CCCAUAAAGUAGAAAGCACUAC............................................................. 22 1 hsa-mir-142_L02* ES_Dicer .........................CAUAAAGUAGAAAGCACUACUA........................................................... 14 1 hsa-mir-142_L03* ES_Dicer .........................CAUAAAGUAGAAAGCACUACU............................................................ 8 1 hsa-mir-142_L04* ES_Dicer ..........................AUAAAGUAGAAAGCACUACUAA.......................................................... 5 1 hsa-mir-142_L05* ES_Dicer .......................CCCAUAAAGUAGAAAGCACUAC............................................................. 5 1 hsa-mir-142_L06* J1_ES_untr ..........................AUAAAGUAGAAAGCACUACU............................................................ 3 1 hsa-mir-142_L07* ES_Dicer ..........................AUAAAGUAGAAAGCACUACUAA.......................................................... 3 1 hsa-mir-142_L08* J1_ES_demeth ........................CCAUAAAGUAGAAAGCACUAC............................................................. 2 1 hsa-mir-142_L09* ES_Dicer .........................CAUAAAGUAGAAAGCACUAC............................................................. 2 1 hsa-mir-142_L10* ES_Dicer .......................CCCAUAAAGUAGAAAGCACUA.............................................................. 2 1 hsa-mir-142_L11* J1_ES_demeth .......................CCCAUAAAGUAGAAAGCACUA.............................................................. 1 1 hsa-mir-142_L12* ES_Dicer ..........................AUAAAGUAGAAAGCACUACUA........................................................... 1 1 hsa-mir-142_L13* ES_Dicer ......................ACCCAUAAAGUAGAAAGCACUA.............................................................. 1 1 hsa-mir-142_L14* J1_ES_untr .......................CCCAUAAAGUAGAAAGCACUA.............................................................. 1 1 hsa-mir-142_L15* J1_ES_untr ..........................AUAAAGUAGAAAGCACUACU............................................................ 1 1 hsa-mir-142_L16* ES_Dicer-DEL ...........................UAAAGUAGAAAGCACUACUAA.......................................................... 1 1 hsa-mir-142_L17* ES_Dicer-DEL ..............................................................GUAGUGUUUCCUACUUUAUGGA...................... 86 1 hsa-mir-142_R01_M ES_Dicer ..............................................................GUAGUGUUUCCUACUUUAUGGA...................... 21 1 hsa-mir-142_R02 J1_ES_demeth ..............................................................GUAGUGUUUCCUACUUUAUGG....................... 17 1 hsa-mir-142_R03 ES_Dicer .............................................................UGUAGUGUUUCCUACUUUAUGGA...................... 15 1 hsa-mir-142_R04 ES_Dicer .............................................................UGUAGUGUUUCCUACUUUAUGG....................... 13 1 hsa-mir-142_R05 ES_Dicer .............................................................UGUAGUGUUUCCUACUUUAUGG....................... 12 1 hsa-mir-142_R06 J1_ES_demeth .............................................................UGUAGUGUUUCCUACUUUAUGGA...................... 9 1 hsa-mir-142_R07 J1_ES_demeth ................................................................AGUGUUUCCUACUUUAUGGAUG.................... 8 1 hsa-mir-142_R08 ES_Dicer ...............................................................UAGUGUUUCCUACUUUAUGGA...................... 8 1 hsa-mir-142_R09 ES_Dicer ..............................................................GUAGUGUUUCCUACUUUAUGGA...................... 5 1 hsa-mir-142_R10 J1_ES_untr .............................................................UGUAGUGUUUCCUACUUUAUGG....................... 5 1 hsa-mir-142_R11 J1_ES_untr .............................................................UGUAGUGUUUCCUACUUUAUGGA...................... 3 1 hsa-mir-142_R12 J1_ES_untr ...............................................................UAGUGUUUCCUACUUUAUGGAU..................... 2 1 hsa-mir-142_R13 ES_Dicer ..............................................................GUAGUGUUUCCUACUUUAUGGAU..................... 2 1 hsa-mir-142_R14 ES_Dicer ..............................................................GUAGUGUUUCCUACUUUAUGG....................... 2 1 hsa-mir-142_R15 J1_ES_demeth ................................................................AGUGUUUCCUACUUUAUGGAU..................... 1 1 hsa-mir-142_R16 ES_Dicer ................................................................AGUGUUUCCUACUUUAUGGAUG.................... 1 1 hsa-mir-142_R17 J1_ES_demeth ...............................................................UAGUGUUUCCUACUUUAUGG....................... 1 1 hsa-mir-142_R18 J1_ES_demeth ...............................................................UAGUGUUUCCUACUUUAUGGA...................... 1 1 hsa-mir-142_R19 J1_ES_demeth hsa-mir-143 chr5:148788654-148788799 + AGCGGAGCAGCGCAGCGCCCUGUCUCCCAGCCUGAGGUGCAGUGCUGCAUCUCUGGUCAGUUGGGAGUCUGAGAUGAAGCACUGUAGCUCAGGAAGAGAGAAGUUGUUCUGCAGCCAUCAGCCUG .((((((((((.(((....)))((((.(..((((((.(((((((((.((((((.((((......)).)).)))))).))))))))).))))))..).)))).))))))))))............. (-59.00) ...................................GGUGCAGUGCUGCAUCUCUGGU.................................................................... 2 1 hsa-mir-143_L01*_M J1_ES_demeth ....................................GUGCAGUGCUGCAUCUCUGGU.................................................................... 1 1 hsa-mir-143_L02* J1_ES_demeth ...................................GGUGCAGUGCUGCAUCUCUGGUC................................................................... 1 1 hsa-mir-143_L03* J1_ES_demeth .....................................................................UGAGAUGAAGCACUGUAGCUC................................... 50 1 hsa-mir-143_R01_M J1_ES_demeth .....................................................................UGAGAUGAAGCACUGUAGCU.................................... 12 1 hsa-mir-143_R02 J1_ES_demeth .....................................................................UGAGAUGAAGCACUGUAGCUCA.................................. 10 1 hsa-mir-143_R03 J1_ES_demeth .....................................................................UGAGAUGAAGCACUGUAGCUC................................... 9 1 hsa-mir-143_R04 J1_ES_untr .....................................................................UGAGAUGAAGCACUGUAGCUCA.................................. 3 1 hsa-mir-143_R05 J1_ES_untr .....................................................................UGAGAUGAAGCACUGUAGCUCA.................................. 2 1 hsa-mir-143_R06 ES_Dicer .....................................................................UGAGAUGAAGCACUGUAGCU.................................... 2 1 hsa-mir-143_R07 ES_Dicer hsa-mir-144 chr17:24212657-24212782 - GUGCCCCCAGUGGGGCCCUGGCUGGGAUAUCAUCAUAUACUGUAAGUUUGCGAUGAGACACUACAGUAUAGAUGAUGUACUAGUCCGGGCACCCCCAGCUCUGGA ......((((.(((((((.((((((.((((((((.(((((((((.((((......))))..))))))))))))))))).)))))).)))).)))......)))). (-48.50) ........................GGAUAUCAUCAUAUACUGUAAGU.......................................................... 1 1 hsa-mir-144_L01_M J1_ES_demeth .............................................................UACAGUAUAGAUGAUGUACUA....................... 1 1 hsa-mir-144_R01*_M ES_Dicer hsa-mir-145 chr5:148790382-148790509 + ACUCGCUCCCACCUUGUCCUCACGGUCCAGUUUUCCCAGGAAUCCCUUAGAUGCUAAGAUGGGGAUUCCUGGAAAUACUGUUCUUGAGGUCAUGGUUUCACAGCUGG ....(((...(((.((.(((((.((..((((.((.((((((((((((.............)))))))))))).)).))))..))))))).)).))).....)))... (-44.02) ........................GUCCAGUUUUCCCAGGAAUCCCU............................................................ 24 1 hsa-mir-145_L01_M J1_ES_demeth ........................GUCCAGUUUUCCCAGGAAUCC.............................................................. 12 1 hsa-mir-145_L02 J1_ES_demeth ........................GUCCAGUUUUCCCAGGAAUCCCU............................................................ 9 1 hsa-mir-145_L03 J1_ES_untr ........................GUCCAGUUUUCCCAGGAAUCCC............................................................. 8 1 hsa-mir-145_L04 J1_ES_demeth ........................GUCCAGUUUUCCCAGGAAUC............................................................... 2 1 hsa-mir-145_L05 ES_Dicer ........................GUCCAGUUUUCCCAGGAAUCCC............................................................. 2 1 hsa-mir-145_L06 J1_ES_untr ........................GUCCAGUUUUCCCAGGAAUCCCUU........................................................... 2 1 hsa-mir-145_L07 J1_ES_demeth ........................GUCCAGUUUUCCCAGGAAUC............................................................... 2 1 hsa-mir-145_L08 J1_ES_demeth ........................GUCCAGUUUUCCCAGGAAU................................................................ 1 1 hsa-mir-145_L09 J1_ES_demeth .........................UCCAGUUUUCCCAGGAAUCCCU............................................................ 1 1 hsa-mir-145_L10 J1_ES_demeth ................................................................AUUCCUGGAAAUACUGUUCUU...................... 6 1 hsa-mir-145_R01*_M J1_ES_demeth ..............................................................GGAUUCCUGGAAAUACUGUUCU....................... 2 1 hsa-mir-145_R02* J1_ES_untr ...............................................................GAUUCCUGGAAAUACUGUUCU....................... 1 1 hsa-mir-145_R03* J1_ES_demeth ................................................................AUUCCUGGAAAUACUGUUCU....................... 1 1 hsa-mir-145_R04* J1_ES_demeth ..............................................................GGAUUCCUGGAAAUACUGUUCU....................... 1 1 hsa-mir-145_R05* J1_ES_demeth hsa-mir-146a chr5:159844917-159845055 + AUCUCUGAAAAGCCGAUGUGUAUCCUCAGCUUUGAGAACUGAAUUCCAUGGGUUGUGUCAGUGUCAGACCUCUGAAAUUCAGUUCUUCAGCUGGGAUAUCUCUGUCAUCGUGGGCUUGAGGA ...(((...(((((.(((.((((((.(((((..((((((((((((.((.(((((.((.......))))))).)).)))))))))))).))))))))))).........))).)))))..))) (-46.70) ................................UGAGAACUGAAUUCCAUGGGUU.................................................................... 6 1 hsa-mir-146a_L01_M J1_ES_untr ................................UGAGAACUGAAUUCCAUGGGUU.................................................................... 2 1 hsa-mir-146a_L02 J1_ES_demeth hsa-mir-146b chr10:104186239-104186351 + CUUUGGCCACCUGGCACUGAGAACUGAAUUCCAUAGGCUGUGAGCUCUAGCAAUGCCCUGUGGACUCAGUUCUGGUGCCCGGCAGUGCUACA ...(((((.((.((((((.((((((((..((((((((..((..((....)).))..)))))))).)))))))))))))).))..).)))).. (-41.20) .................UGAGAACUGAAUUCCAUAGGCUGU................................................... 8 1 hsa-mir-146b_L01_M J1_ES_demeth .................UGAGAACUGAAUUCCAUAGGCUGU................................................... 6 1 hsa-mir-146b_L02 J1_ES_untr .................UGAGAACUGAAUUCCAUAGGCUG.................................................... 2 1 hsa-mir-146b_L03 J1_ES_untr ......................ACUGAAUUCCAUAGGCUGU................................................... 1 1 hsa-mir-146b_L04 J1_ES_demeth .................UGAGAACUGAAUUCCAUAGGCUG.................................................... 1 1 hsa-mir-146b_L05 J1_ES_demeth hsa-mir-147b chr15:43512520-43512639 + AGAGUACUCUAUAAAUCUAGUGGAAACAUUUCUGCACAAACUAGAUUCUGGACACCAGUGUGCGGAAAUGCUUCUGCUACAUUUUUAGGGUUUGUCUAC (((..((((((.((((.(((..(((.((((((((((((.........((((...)))))))))))))))).)))..))).)))).))))))...))).. (-37.80) .........................................................GUGUGCGGAAAUGCUUCUGCUA.................... 2 1 hsa-mir-147b_R01_M ES_Dicer .........................................................GUGUGCGGAAAUGCUUCUGCUA.................... 1 1 hsa-mir-147b_R02 J1_ES_demeth hsa-mir-148a chr7:25956044-25956151 - UUGGUCUUUUGAGGCAAAGUUCUGAGACACUCCGACUCUGAGUAUGAUAGAAGUCAGUGCACUACAGAACUUUGUCUCUAGAGGCUG ..(((((((.((((((((((((((((.((((..(((((((.......))).))))))))..)).)))))))))))))).))))))). (-37.60) ...............AAAGUUCUGAGACACUCCGACU.................................................. 1 1 hsa-mir-148a_L01*_M J1_ES_untr ................AAGUUCUGAGACACUCCGACU.................................................. 1 1 hsa-mir-148a_L02* J1_ES_demeth .....................................................UCAGUGCACUACAGAACUUUGU............ 252 1 hsa-mir-148a_R01_M J1_ES_demeth .....................................................UCAGUGCACUACAGAACUUUGU............ 129 1 hsa-mir-148a_R02 J1_ES_untr .....................................................UCAGUGCACUACAGAACUUUGU............ 90 1 hsa-mir-148a_R03 ES_Dicer .....................................................UCAGUGCACUACAGAACUUUGUC........... 34 1 hsa-mir-148a_R04 J1_ES_demeth .....................................................UCAGUGCACUACAGAACUUUGUC........... 16 1 hsa-mir-148a_R05 J1_ES_untr .....................................................UCAGUGCACUACAGAACUUUGUC........... 6 1 hsa-mir-148a_R06 ES_Dicer .....................................................UCAGUGCACUACAGAACUUU.............. 2 1 hsa-mir-148a_R07 ES_Dicer .....................................................UCAGUGCACUACAGAACUUUGUCU.......... 2 1 hsa-mir-148a_R08 J1_ES_untr ......................................................CAGUGCACUACAGAACUUUGUCU.......... 2 1 hsa-mir-148a_R09 J1_ES_demeth .....................................................UCAGUGCACUACAGAACUUUGUCU.......... 1 1 hsa-mir-148a_R10 ES_Dicer .....................................................UCAGUGCACUACAGAACUUUG............. 1 1 hsa-mir-148a_R11 ES_Dicer ......................................................CAGUGCACUACAGAACUUUGU............ 1 1 hsa-mir-148a_R12 ES_Dicer .....................................................UCAGUGCACUACAGAACUUUGUCU.......... 1 1 hsa-mir-148a_R13 J1_ES_demeth hsa-mir-148b chr12:53017247-53017385 + CAUCAUUUCCAAGCACGAUUAGCAUUUGAGGUGAAGUUCUGUUAUACACUCAGGCUGUGGCUCUCUGAAAGUCAGUGCAUCACAGAACUUUGUCUCGAAAGCUUUCUAGCAGCUACCC ............((..((..(((.(((((((..(((((((((.((.((((..((((....(.....)..)))))))).)).)))))))))..))))))).))).))..))........ (-36.90) ................................GAAGUUCUGUUAUACACUCAGGCU.............................................................. 11 1 hsa-mir-148b_L01*_M J1_ES_demeth ................................GAAGUUCUGUUAUACACUCAG................................................................. 1 1 hsa-mir-148b_L02* ES_Dicer .......................................................................UCAGUGCAUCACAGAACUUUGU......................... 99 1 hsa-mir-148b_R01_M J1_ES_demeth .......................................................................UCAGUGCAUCACAGAACUUUGU......................... 46 1 hsa-mir-148b_R02 J1_ES_untr .......................................................................UCAGUGCAUCACAGAACUUUGU......................... 42 1 hsa-mir-148b_R03 ES_Dicer .......................................................................UCAGUGCAUCACAGAACUUUG.......................... 2 1 hsa-mir-148b_R04 ES_Dicer .......................................................................UCAGUGCAUCACAGAACUU............................ 2 1 hsa-mir-148b_R05 ES_Dicer .......................................................................UCAGUGCAUCACAGAACUUU........................... 1 1 hsa-mir-148b_R06 ES_Dicer .......................................................................UCAGUGCAUCACAGAACUUUGUC........................ 1 1 hsa-mir-148b_R07 ES_Dicer .......................................................................UCAGUGCAUCACAGAACUUUG.......................... 1 1 hsa-mir-148b_R08 J1_ES_demeth .......................................................................UCAGUGCAUCACAGAACUUU........................... 1 1 hsa-mir-148b_R09 J1_ES_demeth hsa-mir-149 chr2:241044071-241044199 + GGCUCCCAGGCCGGCGCCCGAGCUCUGGCUCCGUGUCUUCACUCCCGUGCUUGUCCGAGGAGGGAGGGAGGGACGGGGGCUGUGCUGGGGCAGCUGGAACAACGCAGG .((.......(((((((((.(((.(.(.((((((.(((((.(((((.(.(((....))).))))))))))).)))))).).).))).)))).)))))......))... (-57.42) .......................UCUGGCUCCGUGUCUUCACUCCC.............................................................. 1 1 hsa-mir-149_L01_M ES_Dicer .......................UCUGGCUCCGUGUCUUCACUCCC.............................................................. 1 1 hsa-mir-149_L02 J1_ES_untr hsa-mir-150 chr19:54695834-54695957 - GGCAGCGGCGGCUCCUCUCCCCAUGGCCCUGUCUCCCAACCCUUGUACCAGUGCUGGGCUCAGACCCUGGUACAGGCCUGGGGGACAGGGACCUGGGGACCCCGGCACC .((..(((.((......((((((.((((((((((((((..(((.(((((((.((((....))).).))))))))))..)))))))))))).)))))))))))))))... (-63.30) ...............................UCUCCCAACCCUUGUACCAGUG........................................................ 176 1 hsa-mir-150_L01_M J1_ES_demeth ...............................UCUCCCAACCCUUGUACCAGUGC....................................................... 54 1 hsa-mir-150_L02 J1_ES_demeth ...............................UCUCCCAACCCUUGUACCAGUG........................................................ 45 1 hsa-mir-150_L03 ES_Dicer ...............................UCUCCCAACCCUUGUACCAGU......................................................... 41 1 hsa-mir-150_L04 J1_ES_demeth ...............................UCUCCCAACCCUUGUACCAGUG........................................................ 40 1 hsa-mir-150_L05 J1_ES_untr ...............................UCUCCCAACCCUUGUACCAGU......................................................... 29 1 hsa-mir-150_L06 J1_ES_untr ...............................UCUCCCAACCCUUGUACCAGU......................................................... 9 1 hsa-mir-150_L07 ES_Dicer ...............................UCUCCCAACCCUUGUACCAG.......................................................... 5 1 hsa-mir-150_L08 J1_ES_demeth ...............................UCUCCCAACCCUUGUACCAGUGC....................................................... 4 1 hsa-mir-150_L09 ES_Dicer ..............................GUCUCCCAACCCUUGUACCAGUG........................................................ 2 1 hsa-mir-150_L10 ES_Dicer ...............................UCUCCCAACCCUUGUACCAGUGC....................................................... 2 1 hsa-mir-150_L11 J1_ES_untr ..............................GUCUCCCAACCCUUGUACCAGUGC....................................................... 1 1 hsa-mir-150_L12 ES_Dicer ..............................GUCUCCCAACCCUUGUACCAGUG........................................................ 1 1 hsa-mir-150_L13 J1_ES_untr ..................................CCCAACCCUUGUACCAGU......................................................... 1 1 hsa-mir-150_L14 J1_ES_demeth .............................UGUCUCCCAACCCUUGUACCAGU......................................................... 1 1 hsa-mir-150_L15 J1_ES_demeth ..............................GUCUCCCAACCCUUGUACCAGUGC....................................................... 1 1 hsa-mir-150_L16 J1_ES_demeth ..............................GUCUCCCAACCCUUGUACCAGU......................................................... 1 1 hsa-mir-150_L17 J1_ES_demeth hsa-mir-151 chr8:141811825-141811954 - CUAAAACACUUUUCCUGCCCUCGAGGAGCUCACAGUCUAGUAUGUCUCAUCCCCUACUAGACUGAAGCUCCUUGAGGACAGGGAUGGUCAUACUCACCUCGGUGUUGCC ....((((((.((((((.((((((((((((..((((((((((.(........).)))))))))).)))))))))))).)))))).(((.......)))..))))))... (-51.40) ....................UCGAGGAGCUCACAGUCUAGUA................................................................... 182 1 hsa-mir-151_L01_M J1_ES_untr ....................UCGAGGAGCUCACAGUCUAGU.................................................................... 169 1 hsa-mir-151_L02 J1_ES_demeth ....................UCGAGGAGCUCACAGUCUAGUA................................................................... 151 1 hsa-mir-151_L03 J1_ES_demeth ....................UCGAGGAGCUCACAGUCUAGU.................................................................... 99 1 hsa-mir-151_L04 J1_ES_untr ....................UCGAGGAGCUCACAGUCUAGUAU.................................................................. 34 1 hsa-mir-151_L05 J1_ES_demeth ....................UCGAGGAGCUCACAGUCUAGUAU.................................................................. 18 1 hsa-mir-151_L06 J1_ES_untr ....................UCGAGGAGCUCACAGUCUAGUA................................................................... 9 1 hsa-mir-151_L07 ES_Dicer ....................UCGAGGAGCUCACAGUCUAGU.................................................................... 4 1 hsa-mir-151_L08 ES_Dicer ....................UCGAGGAGCUCACAGUCUAG..................................................................... 4 1 hsa-mir-151_L09 J1_ES_demeth ....................UCGAGGAGCUCACAGUCUAGUAU.................................................................. 2 1 hsa-mir-151_L10 ES_Dicer ....................UCGAGGAGCUCACAGUCUAG..................................................................... 2 1 hsa-mir-151_L11 J1_ES_untr ....................UCGAGGAGCUCACAGUCU....................................................................... 2 1 hsa-mir-151_L12 J1_ES_demeth ...................CUCGAGGAGCUCACAGUCUAGU.................................................................... 1 1 hsa-mir-151_L13 J1_ES_untr ......................GAGGAGCUCACAGUCUAGU.................................................................... 1 1 hsa-mir-151_L14 J1_ES_untr ....................UCGAGGAGCUCACAGUCUA...................................................................... 1 1 hsa-mir-151_L15 J1_ES_demeth hsa-mir-152 chr17:43469506-43469632 - GCUCGGCCCGCUGUCCCCCCCGGCCCAGGUUCUGUGAUACACUCCGACUCGGGCUCUGGAGCAGUCAGUGCAUGACAGAACUUGGGCCCGGAAGGACCUUCUGCACC .....((.....((((..((.((((((((((((((.((.((((..((((...(((....))))))))))).)).)))))))))))))).))..)))).....))... (-50.00) ..........................AGGUUCUGUGAUACACUCCGACU.......................................................... 2 1 hsa-mir-152_L01*_M J1_ES_demeth ................................................................UCAGUGCAUGACAGAACUUGG...................... 40 1 hsa-mir-152_R01_M J1_ES_demeth ................................................................UCAGUGCAUGACAGAACUUGG...................... 10 1 hsa-mir-152_R02 ES_Dicer ................................................................UCAGUGCAUGACAGAACUUGGG..................... 6 1 hsa-mir-152_R03 J1_ES_demeth ................................................................UCAGUGCAUGACAGAACUUGG...................... 5 1 hsa-mir-152_R04 J1_ES_untr ................................................................UCAGUGCAUGACAGAACUUGGG..................... 1 1 hsa-mir-152_R05 J1_ES_untr ................................................................UCAGUGCAUGACAGAACUUG....................... 1 1 hsa-mir-152_R06 J1_ES_demeth hsa-mir-153-1 chr2:219867057-219867186 - CUCUCUCUCCCUCACAGCUGCCAGUGUCAUUUUUGUGAUCUGCAGCUAGUAUUCUCACUCCAGUUGCAUAGUCACAAAAGUGAUCAUUGGCAGGUGUGGCUGCUGCAUGGACAG ....((.(((..((((.((((((((((((((((((((((.((((((((((......)))..)))))))..))))))))))))).))))))))).))))((....))..))).)) (-50.50) ...............................................................UUGCAUAGUCACAAAAGUGAUC............................. 3 2 hsa-mir-153-1_R01_M J1_ES_untr ...............................................................UUGCAUAGUCACAAAAGUGAUCAU........................... 3 2 hsa-mir-153-1_R02 J1_ES_demeth ...............................................................UUGCAUAGUCACAAAAGUGAUCAU........................... 2 2 hsa-mir-153-1_R03 J1_ES_untr ...............................................................UUGCAUAGUCACAAAAGUGAUCA............................ 1 2 hsa-mir-153-1_R04 ES_Dicer hsa-mir-153-2 chr7:157059769-157059895 - CCAGCUAAUUAGCGGUGGCCAGUGUCAUUUUUGUGAUGUUGCAGCUAGUAAUAUGAGCCCAGUUGCAUAGUCACAAAAGUGAUCAUUGGAAACUGUGACUGUACUG .(((.((....(((((..(((((((((((((((((((..(((((((.((.......))..)))))))..))))))))))))).))))))..))))).....))))) (-42.90) ..............................................................UUGCAUAGUCACAAAAGUGAUC...................... 3 2 hsa-mir-153-2_R01_M J1_ES_untr ..............................................................UUGCAUAGUCACAAAAGUGAUCAU.................... 3 2 hsa-mir-153-2_R02 J1_ES_demeth ..............................................................UUGCAUAGUCACAAAAGUGAUCAU.................... 2 2 hsa-mir-153-2_R03 J1_ES_untr ..............................................................UUGCAUAGUCACAAAAGUGAUCA..................... 1 2 hsa-mir-153-2_R04 ES_Dicer hsa-mir-154 chr14:100595825-100595948 + CGCUAGCGUGUGGUACUUGAAGAUAGGUUAUCCGUGUUGCCUUCGCUUUAUUUGUGACGAAUCAUACACGGUUGACCUAUUUUUCAGUACCAAAUCCCGCCUU .....(((..(((((((.((((((((((((.((((((....(((((.........).))))....)))))).)))))))))))).))))))).....)))... (-40.50) .......................UAGGUUAUCCGUGUUGCCUUCG.......................................................... 110 1 hsa-mir-154_L01*_M J1_ES_untr .......................UAGGUUAUCCGUGUUGCCUUCG.......................................................... 93 1 hsa-mir-154_L02* J1_ES_demeth .......................UAGGUUAUCCGUGUUGCCUUCG.......................................................... 15 1 hsa-mir-154_L03* ES_Dicer .......................UAGGUUAUCCGUGUUGCCUUC........................................................... 12 1 hsa-mir-154_L04* J1_ES_demeth .......................UAGGUUAUCCGUGUUGCCUUC........................................................... 5 1 hsa-mir-154_L05* J1_ES_untr .......................UAGGUUAUCCGUGUUGCCUU............................................................ 3 1 hsa-mir-154_L06* ES_Dicer .......................UAGGUUAUCCGUGUUGCCUUC........................................................... 2 1 hsa-mir-154_L07* ES_Dicer .......................UAGGUUAUCCGUGUUGCCUU............................................................ 1 1 hsa-mir-154_L08* J1_ES_demeth ...........................................................AAUCAUACACGGUUGACCUAUU...................... 1074 1 hsa-mir-154_R01_M J1_ES_untr ...........................................................AAUCAUACACGGUUGACCUAUU...................... 540 1 hsa-mir-154_R02 J1_ES_demeth ...........................................................AAUCAUACACGGUUGACCUAUU...................... 338 1 hsa-mir-154_R03 ES_Dicer ...........................................................AAUCAUACACGGUUGACCUAU....................... 59 1 hsa-mir-154_R04 J1_ES_untr ...........................................................AAUCAUACACGGUUGACCUAU....................... 56 1 hsa-mir-154_R05 J1_ES_demeth ...........................................................AAUCAUACACGGUUGACCUAU....................... 30 1 hsa-mir-154_R06 ES_Dicer ...........................................................AAUCAUACACGGUUGACCUAUUU..................... 20 1 hsa-mir-154_R07 J1_ES_untr ...........................................................AAUCAUACACGGUUGACCUA........................ 9 1 hsa-mir-154_R08 ES_Dicer ...........................................................AAUCAUACACGGUUGACCUAUUU..................... 8 1 hsa-mir-154_R09 J1_ES_demeth ............................................................AUCAUACACGGUUGACCUAUU...................... 7 1 hsa-mir-154_R10 ES_Dicer ...........................................................AAUCAUACACGGUUGACCUAUUU..................... 6 1 hsa-mir-154_R11 ES_Dicer ............................................................AUCAUACACGGUUGACCUAUU...................... 6 1 hsa-mir-154_R12 J1_ES_demeth ............................................................AUCAUACACGGUUGACCUAUU...................... 3 1 hsa-mir-154_R13 J1_ES_untr ...........................................................AAUCAUACACGGUUGACCU......................... 2 1 hsa-mir-154_R14 ES_Dicer ...........................................................AAUCAUACACGGUUGACCU......................... 2 1 hsa-mir-154_R15 J1_ES_untr ............................................................AUCAUACACGGUUGACCUAUUU..................... 1 1 hsa-mir-154_R16 ES_Dicer .............................................................UCAUACACGGUUGACCUAUU...................... 1 1 hsa-mir-154_R17 ES_Dicer ..........................................................GAAUCAUACACGGUUGACCUAUU...................... 1 1 hsa-mir-154_R18 J1_ES_untr ...........................................................AAUCAUACACGGUUGACCUAUUUU.................... 1 1 hsa-mir-154_R19 J1_ES_untr hsa-mir-15a chr13:49521236-49521358 - UAAAAAAAAUAAAACCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGGAUCUGAUCU ..............(((((.......(..((((((((..((((((((((..((.....))..))))))))))..))))))))..).......)))))......... (-32.34) ...........................UAGCAGCACAUAAUGGUUUGUG......................................................... 150 1 hsa-mir-15a_L01_M J1_ES_demeth ...........................UAGCAGCACAUAAUGGUUUGU.......................................................... 118 1 hsa-mir-15a_L02 J1_ES_demeth ...........................UAGCAGCACAUAAUGGUUUGUG......................................................... 86 1 hsa-mir-15a_L03 J1_ES_untr ...........................UAGCAGCACAUAAUGGUUUGUG......................................................... 52 1 hsa-mir-15a_L04 ES_Dicer ...........................UAGCAGCACAUAAUGGUUUGU.......................................................... 49 1 hsa-mir-15a_L05 J1_ES_untr ...........................UAGCAGCACAUAAUGGUUUGU.......................................................... 44 1 hsa-mir-15a_L06 ES_Dicer ...........................UAGCAGCACAUAAUGGUUUG........................................................... 30 1 hsa-mir-15a_L07 ES_Dicer ...........................UAGCAGCACAUAAUGGUUU............................................................ 17 1 hsa-mir-15a_L08 ES_Dicer ...........................UAGCAGCACAUAAUGGUUUGUGGA....................................................... 4 1 hsa-mir-15a_L09 J1_ES_untr ...........................UAGCAGCACAUAAUGGUUUGUGG........................................................ 3 1 hsa-mir-15a_L10 ES_Dicer ...........................UAGCAGCACAUAAUGGUUUGUGGA....................................................... 3 1 hsa-mir-15a_L11 ES_Dicer ...........................UAGCAGCACAUAAUGGUUUGUGGA....................................................... 2 1 hsa-mir-15a_L12 J1_ES_demeth ...........................UAGCAGCACAUAAUGGUUUGUGG........................................................ 2 1 hsa-mir-15a_L13 J1_ES_demeth ...........................UAGCAGCACAUAAUGGUUUGUGGAU...................................................... 1 1 hsa-mir-15a_L14 J1_ES_untr ...........................UAGCAGCACAUAAUGGUUUG........................................................... 1 1 hsa-mir-15a_L15 J1_ES_untr ..........................GUAGCAGCACAUAAUGGUUUG........................................................... 1 1 hsa-mir-15a_L16 J1_ES_demeth ...........................UAGCAGCACAUAAUGGUUUG........................................................... 1 1 hsa-mir-15a_L17 J1_ES_demeth hsa-mir-15b chr3:161605050-161605187 + AAUCCUACAUUUUUGAGGCCUUAAAGUACUGUAGCAGCACAUCAUGGUUUACAUGCUACAGUCAAGAUGCGAAUCAUUAUUUGCUGCUCUAGAAAUUUAAGGAAAUUCAUUCAAAACUAU .............((((.(((((((...(((.(((((((.((.((((((..(((.((.......)))))..)))))).)).))))))).)))...)))))))...))))........... (-32.70) ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 1504 1 hsa-mir-15b_L01_M J1_ES_untr ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 1451 1 hsa-mir-15b_L02 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 438 1 hsa-mir-15b_L03 ES_Dicer ...............................UAGCAGCACAUCAUGGUUUAC.................................................................... 429 1 hsa-mir-15b_L04 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUUUAC.................................................................... 334 1 hsa-mir-15b_L05 J1_ES_untr ...............................UAGCAGCACAUCAUGGUUUAC.................................................................... 127 1 hsa-mir-15b_L06 ES_Dicer ...............................UAGCAGCACAUCAUGGUUUA..................................................................... 38 1 hsa-mir-15b_L07 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUUUA..................................................................... 23 1 hsa-mir-15b_L08 J1_ES_untr ...............................UAGCAGCACAUCAUGGUUU...................................................................... 21 1 hsa-mir-15b_L09 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUUUACAU.................................................................. 9 1 hsa-mir-15b_L10 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUUUACAU.................................................................. 6 1 hsa-mir-15b_L11 J1_ES_untr ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 5 1 hsa-mir-15b_L12 ES_Dicer-DEL ...............................UAGCAGCACAUCAUGGUUU...................................................................... 4 1 hsa-mir-15b_L13 J1_ES_untr ..............................GUAGCAGCACAUCAUGGUUUACA................................................................... 3 1 hsa-mir-15b_L14 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUUUA..................................................................... 2 1 hsa-mir-15b_L15 ES_Dicer ...............................UAGCAGCACAUCAUGGUUUACAU.................................................................. 2 1 hsa-mir-15b_L16 ES_Dicer-DEL ...............................UAGCAGCACAUCAUGGUUUAC.................................................................... 2 1 hsa-mir-15b_L17 ES_Dicer-DEL ...............................UAGCAGCACAUCAUGGUUUA..................................................................... 2 1 hsa-mir-15b_L18 ES_Dicer-DEL ................................AGCAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L19 ES_Dicer ...............................UAGCAGCACAUCAUGGUUU...................................................................... 1 1 hsa-mir-15b_L20 ES_Dicer ..................................CAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L21 ES_Dicer ................................AGCAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L22 J1_ES_demeth ..............................GUAGCAGCACAUCAUGGUUUAC.................................................................... 1 1 hsa-mir-15b_L23 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUU....................................................................... 1 1 hsa-mir-15b_L24 J1_ES_demeth ...............................UAGCAGCACAUCAUGGUU....................................................................... 1 1 hsa-mir-15b_L25 J1_ES_untr ..............................GUAGCAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L26 J1_ES_untr ..................................CAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L27 ES_Dicer-DEL .....................................................................CGAAUCAUUAUUUGCUGCUCUA............................. 12 1 hsa-mir-15b_R01*_M J1_ES_demeth .....................................................................CGAAUCAUUAUUUGCUGCUCUA............................. 6 1 hsa-mir-15b_R02* J1_ES_untr .....................................................................CGAAUCAUUAUUUGCUGCUCU.............................. 4 1 hsa-mir-15b_R03* J1_ES_untr .....................................................................CGAAUCAUUAUUUGCUGCUCU.............................. 3 1 hsa-mir-15b_R04* ES_Dicer ....................................................................GCGAAUCAUUAUUUGCUGCUCU.............................. 3 1 hsa-mir-15b_R05* J1_ES_demeth .....................................................................CGAAUCAUUAUUUGCUGCUCU.............................. 2 1 hsa-mir-15b_R06* J1_ES_demeth ...................................................................UGCGAAUCAUUAUUUGCUGCUC............................... 1 1 hsa-mir-15b_R07* J1_ES_demeth .....................................................................CGAAUCAUUAUUUGCUGC................................. 1 1 hsa-mir-15b_R08* J1_ES_demeth ....................................................................GCGAAUCAUUAUUUGCUGCUCUA............................. 1 1 hsa-mir-15b_R09* J1_ES_demeth .....................................................................CGAAUCAUUAUUUGCUGCUC............................... 1 1 hsa-mir-15b_R10* J1_ES_untr ....................................................................GCGAAUCAUUAUUUGCUGCUCU.............................. 1 1 hsa-mir-15b_R11* J1_ES_untr hsa-mir-16-1 chr13:49521090-49521218 - UGAUAGCAAUGUCAGCAGUGCCUUAGCAGCACGUAAAUAUUGGCGUUAAGAUUCUAAAAUUAUCUCCAGUAUUAACUGUGCUGCUGAAGUAAGGUUGACCAUACUCUACAGUU ..........((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..)))))).............. (-38.50) .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 1406 2 hsa-mir-16-1_L01_M J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 1089 2 hsa-mir-16-1_L02 J1_ES_untr .......................UAGCAGCACGUAAAUAUUGGCGU................................................................... 464 2 hsa-mir-16-1_L03 J1_ES_untr .......................UAGCAGCACGUAAAUAUUGGCGU................................................................... 450 2 hsa-mir-16-1_L04 J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 352 2 hsa-mir-16-1_L05 ES_Dicer .......................UAGCAGCACGUAAAUAUUGGC..................................................................... 95 2 hsa-mir-16-1_L06 J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGGC..................................................................... 59 2 hsa-mir-16-1_L07 ES_Dicer .......................UAGCAGCACGUAAAUAUUGGC..................................................................... 59 2 hsa-mir-16-1_L08 J1_ES_untr .......................UAGCAGCACGUAAAUAUUGG...................................................................... 15 2 hsa-mir-16-1_L09 J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGG...................................................................... 7 2 hsa-mir-16-1_L10 ES_Dicer .......................UAGCAGCACGUAAAUAUUGGCGU................................................................... 7 2 hsa-mir-16-1_L11 ES_Dicer .......................UAGCAGCACGUAAAUAUUGGCGUU.................................................................. 7 1 hsa-mir-16-1_L12 J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGGCGUU.................................................................. 7 1 hsa-mir-16-1_L13 J1_ES_untr .......................UAGCAGCACGUAAAUAUUG....................................................................... 4 2 hsa-mir-16-1_L14 ES_Dicer .......................UAGCAGCACGUAAAUAUUGGCGUUA................................................................. 3 1 hsa-mir-16-1_L15 J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGG...................................................................... 3 2 hsa-mir-16-1_L16 J1_ES_untr .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 3 2 hsa-mir-16-1_L17 ES_Dicer-DEL ........................AGCAGCACGUAAAUAUUGGCGU................................................................... 2 2 hsa-mir-16-1_L18 J1_ES_demeth .......................UAGCAGCACGUAAAUAUUGGCGUUA................................................................. 2 1 hsa-mir-16-1_L19 J1_ES_untr .......................UAGCAGCACGUAAAUAUUGGC..................................................................... 2 2 hsa-mir-16-1_L20 ES_Dicer-DEL ........................AGCAGCACGUAAAUAUUGGCGU................................................................... 1 2 hsa-mir-16-1_L21 ES_Dicer ..........................CAGCACGUAAAUAUUGGCG.................................................................... 1 2 hsa-mir-16-1_L22 ES_Dicer ............................GCACGUAAAUAUUGGCGU................................................................... 1 2 hsa-mir-16-1_L23 J1_ES_demeth ........................AGCAGCACGUAAAUAUUGGCGU................................................................... 1 2 hsa-mir-16-1_L24 J1_ES_untr ........................AGCAGCACGUAAAUAUUGGCG.................................................................... 1 2 hsa-mir-16-1_L25 J1_ES_untr .......................UAGCAGCACGUAAAUAUUGG...................................................................... 1 2 hsa-mir-16-1_L26 ES_Dicer-DEL .......................UAGCAGCACGUAAAUAUUGGCGUU.................................................................. 1 1 hsa-mir-16-1_L27 ES_Dicer-DEL hsa-mir-16-2 chr3:161605207-161605327 + UGACAUACUUGUUCCACUCUAGCAGCACGUAAAUAUUGGCGUAGUGAAAUAUAUAUUAAACACCAAUAUUACUGUGCUGCUUUAGUGUGACAGGGAUACAG .......(((((..((((..(((((((((..((((((((.((..(((........))).)).))))))))..)))))))))..))))..)))))....... (-37.40) ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 1406 2 hsa-mir-16-2_L01_M J1_ES_demeth ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 1089 2 hsa-mir-16-2_L02 J1_ES_untr ...................UAGCAGCACGUAAAUAUUGGCGU........................................................... 464 2 hsa-mir-16-2_L03 J1_ES_untr ...................UAGCAGCACGUAAAUAUUGGCGU........................................................... 450 2 hsa-mir-16-2_L04 J1_ES_demeth ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 352 2 hsa-mir-16-2_L05 ES_Dicer ...................UAGCAGCACGUAAAUAUUGGC............................................................. 95 2 hsa-mir-16-2_L06 J1_ES_demeth ...................UAGCAGCACGUAAAUAUUGGC............................................................. 59 2 hsa-mir-16-2_L07 ES_Dicer ...................UAGCAGCACGUAAAUAUUGGC............................................................. 59 2 hsa-mir-16-2_L08 J1_ES_untr ...................UAGCAGCACGUAAAUAUUGG.............................................................. 15 2 hsa-mir-16-2_L09 J1_ES_demeth ...................UAGCAGCACGUAAAUAUUGGCGUA.......................................................... 11 1 hsa-mir-16-2_L10 J1_ES_untr ...................UAGCAGCACGUAAAUAUUGGCGUA.......................................................... 8 1 hsa-mir-16-2_L11 J1_ES_demeth ...................UAGCAGCACGUAAAUAUUGG.............................................................. 7 2 hsa-mir-16-2_L12 ES_Dicer ...................UAGCAGCACGUAAAUAUUGGCGU........................................................... 7 2 hsa-mir-16-2_L13 ES_Dicer ...................UAGCAGCACGUAAAUAUUG............................................................... 4 2 hsa-mir-16-2_L14 ES_Dicer ...................UAGCAGCACGUAAAUAUUGG.............................................................. 3 2 hsa-mir-16-2_L15 J1_ES_untr ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 3 2 hsa-mir-16-2_L16 ES_Dicer-DEL ....................AGCAGCACGUAAAUAUUGGCGU........................................................... 2 2 hsa-mir-16-2_L17 J1_ES_demeth ...................UAGCAGCACGUAAAUAUUGGC............................................................. 2 2 hsa-mir-16-2_L18 ES_Dicer-DEL ..................CUAGCAGCACGUAAAUAUUGG.............................................................. 1 1 hsa-mir-16-2_L19 ES_Dicer ....................AGCAGCACGUAAAUAUUGGCGU........................................................... 1 2 hsa-mir-16-2_L20 ES_Dicer ......................CAGCACGUAAAUAUUGGCG............................................................ 1 2 hsa-mir-16-2_L21 ES_Dicer ........................GCACGUAAAUAUUGGCGU........................................................... 1 2 hsa-mir-16-2_L22 J1_ES_demeth ..................CUAGCAGCACGUAAAUAUUGGCGU........................................................... 1 1 hsa-mir-16-2_L23 J1_ES_untr ....................AGCAGCACGUAAAUAUUGGCGU........................................................... 1 2 hsa-mir-16-2_L24 J1_ES_untr ....................AGCAGCACGUAAAUAUUGGCG............................................................ 1 2 hsa-mir-16-2_L25 J1_ES_untr ...................UAGCAGCACGUAAAUAUUGG.............................................................. 1 2 hsa-mir-16-2_L26 ES_Dicer-DEL ...................UAGCAGCACGUAAAUAUUGGCGUAG......................................................... 1 1 hsa-mir-16-2_L27 ES_Dicer-DEL hsa-mir-17 chr13:90800840-90800963 + UUGUGACCAGUCAGAAUAAUGUCAAAGUGCUUACAGUGCAGGUAGUGAUAUGUGCAUCUACUGCAGUGAAGGCACUUGUAGCAUUAUGGUGACAGCUGCCUCG .........((((..(((((((..((((((((.((.(((((.(((((.......)).)))))))).)).))))))))...)))))))..)))).......... (-36.20) ......................CAAAGUGCUUACAGUGCAGGUAG.......................................................... 593 1 hsa-mir-17_L01_M J1_ES_demeth ......................CAAAGUGCUUACAGUGCAGGUAG.......................................................... 545 1 hsa-mir-17_L02 J1_ES_untr ......................CAAAGUGCUUACAGUGCAGGUAG.......................................................... 490 1 hsa-mir-17_L03 ES_Dicer ......................CAAAGUGCUUACAGUGCAGGUAGU......................................................... 44 1 hsa-mir-17_L04 J1_ES_untr ......................CAAAGUGCUUACAGUGCAGGUA........................................................... 38 1 hsa-mir-17_L05 J1_ES_untr ......................CAAAGUGCUUACAGUGCAGGUAGU......................................................... 32 1 hsa-mir-17_L06 J1_ES_demeth ......................CAAAGUGCUUACAGUGCAGGU............................................................ 30 1 hsa-mir-17_L07 ES_Dicer ......................CAAAGUGCUUACAGUGCAGGUAGU......................................................... 25 1 hsa-mir-17_L08 ES_Dicer ......................CAAAGUGCUUACAGUGCAGGUA........................................................... 11 1 hsa-mir-17_L09 J1_ES_demeth ......................CAAAGUGCUUACAGUGCAGGU............................................................ 11 1 hsa-mir-17_L10 J1_ES_demeth ......................CAAAGUGCUUACAGUGCAGGUA........................................................... 8 1 hsa-mir-17_L11 ES_Dicer ......................CAAAGUGCUUACAGUGCAGGU............................................................ 8 1 hsa-mir-17_L12 J1_ES_untr .....................UCAAAGUGCUUACAGUGCAGGUAG.......................................................... 7 1 hsa-mir-17_L13 J1_ES_untr .....................UCAAAGUGCUUACAGUGCAGGU............................................................ 7 1 hsa-mir-17_L14 J1_ES_untr .....................UCAAAGUGCUUACAGUGCAGGU............................................................ 4 1 hsa-mir-17_L15 ES_Dicer .....................UCAAAGUGCUUACAGUGCAGGU............................................................ 4 1 hsa-mir-17_L16 J1_ES_demeth .....................UCAAAGUGCUUACAGUGCAGGUAG.......................................................... 3 1 hsa-mir-17_L17 ES_Dicer .....................UCAAAGUGCUUACAGUGCAGGUA........................................................... 3 1 hsa-mir-17_L18 J1_ES_untr .....................UCAAAGUGCUUACAGUGCAGGUAG.......................................................... 3 1 hsa-mir-17_L19 J1_ES_demeth ..........................GUGCUUACAGUGCAGGUAG.......................................................... 2 2 hsa-mir-17_L20 ES_Dicer ......................CAAAGUGCUUACAGUGCAG.............................................................. 2 1 hsa-mir-17_L21 ES_Dicer ......................CAAAGUGCUUACAGUGCAG.............................................................. 2 1 hsa-mir-17_L22 J1_ES_demeth .....................UCAAAGUGCUUACAGUGCAGGUA........................................................... 2 1 hsa-mir-17_L23 J1_ES_demeth .........................AGUGCUUACAGUGCAGGUAG.......................................................... 1 2 hsa-mir-17_L24 ES_Dicer ...........................UGCUUACAGUGCAGGUAG.......................................................... 1 2 hsa-mir-17_L25 ES_Dicer .......................AAAGUGCUUACAGUGCAGGUAG.......................................................... 1 2 hsa-mir-17_L26 J1_ES_untr ......................CAAAGUGCUUACAGUGCAG.............................................................. 1 1 hsa-mir-17_L27 J1_ES_untr ......................CAAAGUGCUUACAGUGCA............................................................... 1 1 hsa-mir-17_L28 J1_ES_demeth hsa-mir-181a-1 chr1:197094776-197094925 - GAGUAGAAUUCUGAGUUUUGAGGUUGCUUCAGUGAACAUUCAACGCUGUCGGUGAGUUUGGAAUUAAAAUCAAAACCAUCGACCGUUGAUUGUACCCUAUGGCUAACCAUCAUCUACUCCAUGGUGCUCAGAA (((((..((...((((..((((((((((..((.(.(((.((((((..(((((((.((((.((.......)).))))))))))))))))).))).).))..))).)))).)))...)))).))..))))).... (-43.90) ..................................AACAUUCAACGCUGUCGGUGAGUUU.......................................................................... 188 2 hsa-mir-181a-1_L01_M J1_ES_demeth ..................................AACAUUCAACGCUGUCGGUGAGUU........................................................................... 48 2 hsa-mir-181a-1_L02 J1_ES_demeth ..................................AACAUUCAACGCUGUCGGUGAGU............................................................................ 24 2 hsa-mir-181a-1_L03 J1_ES_demeth ..................................AACAUUCAACGCUGUCGGUGAGUUU.......................................................................... 17 2 hsa-mir-181a-1_L04 J1_ES_untr ..................................AACAUUCAACGCUGUCGGUGAG............................................................................. 12 2 hsa-mir-181a-1_L05 J1_ES_demeth ..................................AACAUUCAACGCUGUCGGUGA.............................................................................. 7 2 hsa-mir-181a-1_L06 J1_ES_demeth ..................................AACAUUCAACGCUGUCGGUGAGUU........................................................................... 7 2 hsa-mir-181a-1_L07 J1_ES_untr ...................................ACAUUCAACGCUGUCGGUGAGUUU.......................................................................... 6 2 hsa-mir-181a-1_L08 J1_ES_demeth ...................................ACAUUCAACGCUGUCGGUGAGUUU.......................................................................... 1 2 hsa-mir-181a-1_L09 J1_ES_untr ..................................AACAUUCAACGCUGUCGGUGAGU............................................................................ 1 2 hsa-mir-181a-1_L10 J1_ES_untr ..........................................................................ACCAUCGACCGUUGAUUGUACC..................................... 1 1 hsa-mir-181a-1_R01*_M J1_ES_demeth hsa-mir-181a-2 chr9:126494522-126494671 + GGAGAAUGAAGAAGGGCUAUCAGGCCAGCCUUCAGAGGACUCCAAGGAACAUUCAACGCUGUCGGUGAGUUUGGGAUUUGAAAAAACCACUGACCGUUGACUGUACCUUGGGGUCCUUACAGACGACAC (..(..(((((...((((....))))...)))))(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).....)..).. (-56.70) ...............................................AACAUUCAACGCUGUCGGUGAGUUU......................................................... 188 2 hsa-mir-181a-2_L01_M J1_ES_demeth ...............................................AACAUUCAACGCUGUCGGUGAGUU.......................................................... 48 2 hsa-mir-181a-2_L02 J1_ES_demeth ...............................................AACAUUCAACGCUGUCGGUGAGU........................................................... 24 2 hsa-mir-181a-2_L03 J1_ES_demeth ...............................................AACAUUCAACGCUGUCGGUGAGUUU......................................................... 17 2 hsa-mir-181a-2_L04 J1_ES_untr ...............................................AACAUUCAACGCUGUCGGUGAG............................................................ 12 2 hsa-mir-181a-2_L05 J1_ES_demeth ...............................................AACAUUCAACGCUGUCGGUGA............................................................. 7 2 hsa-mir-181a-2_L06 J1_ES_demeth ...............................................AACAUUCAACGCUGUCGGUGAGUU.......................................................... 7 2 hsa-mir-181a-2_L07 J1_ES_untr ................................................ACAUUCAACGCUGUCGGUGAGUUU......................................................... 6 2 hsa-mir-181a-2_L08 J1_ES_demeth ................................................ACAUUCAACGCUGUCGGUGAGUUU......................................................... 1 2 hsa-mir-181a-2_L09 J1_ES_untr ...............................................AACAUUCAACGCUGUCGGUGAGU........................................................... 1 2 hsa-mir-181a-2_L10 J1_ES_untr hsa-mir-181b-1 chr1:197094605-197094754 - CUUUCUCUUCCCUGUGCAGAGAUUAUUUUUUAAAAGGUCACAAUCAACAUUCAUUGCUGUCGGUGGGUUGAACUGUGUGGACAAGCUCACUGAACAAUGAAUGCAACUGUGGCCCCGCUUUUUGCUGUC ...(((((.(.....).))))).............(((((((.....(((((((((...((((((((((...((....))...)))))))))).)))))))))....)))))))..((.....)).... (-38.70) .............................................AACAUUCAUUGCUGUCGGUGGGUU............................................................ 43 2 hsa-mir-181b-1_L01_M J1_ES_demeth .............................................AACAUUCAUUGCUGUCGGUGGG.............................................................. 9 2 hsa-mir-181b-1_L02 J1_ES_demeth .............................................AACAUUCAUUGCUGUCGGUGGGU............................................................. 4 2 hsa-mir-181b-1_L03 J1_ES_demeth .............................................AACAUUCAUUGCUGUCGGUGGGUU............................................................ 4 2 hsa-mir-181b-1_L04 J1_ES_untr .............................................AACAUUCAUUGCUGUCGGUGG............................................................... 2 2 hsa-mir-181b-1_L05 J1_ES_demeth hsa-mir-181b-2 chr9:126495790-126495918 + CUGAAAACACUGAUGGCUGCACUCAACAUUCAUUGCUGUCGGUGGGUUUGAGUCUGAAUCAACUCACUGAUCAAUGAAUGCAAACUGCGGACCAAACAACCCAAAGGA .............((((((((.....(((((((((..(((((((((((.((.......)))))))))))))))))))))).....))))).))).....((....)). (-35.30) ........................AACAUUCAUUGCUGUCGGUGGGUU............................................................ 43 2 hsa-mir-181b-2_L01_M J1_ES_demeth ........................AACAUUCAUUGCUGUCGGUGGG.............................................................. 9 2 hsa-mir-181b-2_L02 J1_ES_demeth ........................AACAUUCAUUGCUGUCGGUGGGUUU........................................................... 9 1 hsa-mir-181b-2_L03 J1_ES_demeth ........................AACAUUCAUUGCUGUCGGUGGGU............................................................. 4 2 hsa-mir-181b-2_L04 J1_ES_demeth ........................AACAUUCAUUGCUGUCGGUGGGUU............................................................ 4 2 hsa-mir-181b-2_L05 J1_ES_untr ........................AACAUUCAUUGCUGUCGGUGG............................................................... 2 2 hsa-mir-181b-2_L06 J1_ES_demeth ........................AACAUUCAUUGCUGUCGGUGGGUUU........................................................... 1 1 hsa-mir-181b-2_L07 J1_ES_untr hsa-mir-181c chr19:13846493-13846642 + ACUCCAGGUCCCGGAAAAUUUGCCAAGGGUUUGGGGGAACAUUCAACCUGUCGGUGAGUUUGGGCAGCUCAGGCAAACCAUCGACCGUUGAGUGGACCCUGAGGCCUGGAAUUGCCAUCCUCCUGCCGGUG (((.((((....(((.......(((.((.((..(((...((((((((..(((((((.(((((...........)))))))))))).))))))))..)))..)).)))))........))).))))..))). (-49.26) .....................................AACAUUCAACCUGUCGGUGAGUUU...................................................................... 983 1 hsa-mir-181c_L01_M J1_ES_demeth .....................................AACAUUCAACCUGUCGGUGAGUUU...................................................................... 421 1 hsa-mir-181c_L02 J1_ES_untr .....................................AACAUUCAACCUGUCGGUGAGUU....................................................................... 211 1 hsa-mir-181c_L03 J1_ES_demeth .....................................AACAUUCAACCUGUCGGUGAGUU....................................................................... 137 1 hsa-mir-181c_L04 J1_ES_untr .....................................AACAUUCAACCUGUCGGUGAGUUUG..................................................................... 43 1 hsa-mir-181c_L05 J1_ES_demeth .....................................AACAUUCAACCUGUCGGUGAGUUU...................................................................... 31 1 hsa-mir-181c_L06 ES_Dicer .....................................AACAUUCAACCUGUCGGUGAGUU....................................................................... 23 1 hsa-mir-181c_L07 ES_Dicer .....................................AACAUUCAACCUGUCGGUGAGU........................................................................ 15 1 hsa-mir-181c_L08 J1_ES_untr .....................................AACAUUCAACCUGUCGGUGAGUUUG..................................................................... 14 1 hsa-mir-181c_L09 J1_ES_untr .....................................AACAUUCAACCUGUCGGUGAGU........................................................................ 14 1 hsa-mir-181c_L10 J1_ES_demeth ....................................GAACAUUCAACCUGUCGGUGAGUUU...................................................................... 12 1 hsa-mir-181c_L11 J1_ES_demeth ......................................ACAUUCAACCUGUCGGUGAGUUU...................................................................... 7 1 hsa-mir-181c_L12 J1_ES_demeth ....................................GAACAUUCAACCUGUCGGUGAGUUU...................................................................... 6 1 hsa-mir-181c_L13 J1_ES_untr ......................................ACAUUCAACCUGUCGGUGAGUU....................................................................... 4 1 hsa-mir-181c_L14 J1_ES_demeth .....................................AACAUUCAACCUGUCGGUGAGU........................................................................ 3 1 hsa-mir-181c_L15 ES_Dicer .....................................AACAUUCAACCUGUCGGUGAG......................................................................... 3 1 hsa-mir-181c_L16 J1_ES_untr ....................................GAACAUUCAACCUGUCGGUGAGU........................................................................ 2 1 hsa-mir-181c_L17 J1_ES_untr .....................................AACAUUCAACCUGUCGGUGAG......................................................................... 2 1 hsa-mir-181c_L18 J1_ES_demeth ....................................GAACAUUCAACCUGUCGGUGAGUU....................................................................... 2 1 hsa-mir-181c_L19 J1_ES_demeth .........................................UUCAACCUGUCGGUGAGUUU...................................................................... 2 1 hsa-mir-181c_L20 J1_ES_demeth ........................................AUUCAACCUGUCGGUGAGUUU...................................................................... 2 1 hsa-mir-181c_L21 J1_ES_demeth ....................................GAACAUUCAACCUGUCGGUGAGU........................................................................ 1 1 hsa-mir-181c_L22 ES_Dicer .....................................AACAUUCAACCUGUCGGUGAG......................................................................... 1 1 hsa-mir-181c_L23 ES_Dicer ......................................ACAUUCAACCUGUCGGUGAGUUU...................................................................... 1 1 hsa-mir-181c_L24 J1_ES_untr .....................................AACAUUCAACCUGUCGGUGA.......................................................................... 1 1 hsa-mir-181c_L25 J1_ES_demeth ......................................ACAUUCAACCUGUCGGUGAGUUUG..................................................................... 1 1 hsa-mir-181c_L26 J1_ES_demeth ..........................................UCAACCUGUCGGUGAGUUU...................................................................... 1 1 hsa-mir-181c_L27 J1_ES_demeth ....................................GAACAUUCAACCUGUCGGUGAGU........................................................................ 1 1 hsa-mir-181c_L28 J1_ES_demeth ...........................................................................AACCAUCGACCGUUGAGUGGAC.................................. 4 1 hsa-mir-181c_R01*_M J1_ES_demeth ............................................................................ACCAUCGACCGUUGAGUGG.................................... 2 1 hsa-mir-181c_R02* ES_Dicer .............................................................................CCAUCGACCGUUGAGUGGACC................................. 1 1 hsa-mir-181c_R03* ES_Dicer ...........................................................................AACCAUCGACCGUUGAGUGGA................................... 1 1 hsa-mir-181c_R04* J1_ES_untr ............................................................................ACCAUCGACCGUUGAGUGGA................................... 1 1 hsa-mir-181c_R05* J1_ES_demeth hsa-mir-181d chr19:13846669-13846845 + CCUGGGCACGUCCCCUCCCCUAGGCCACAGCCGAGGUCACAAUCAACAUUCAUUGUUGUCGGUGGGUUGUGAGGACUGAGGCCAGACCCACCGGGGGAUGAAUGUCACUGUGGCUGGGCCAGACACGGCUUAAGGGGAAUGGGGACUGGGGACAGG ((((..(..(((((((((((((((((...(((..(((((((....(((((((((.(..((((((((((....((.(....))).))))))))))).)))))))))...))))))).))).......))))).))))))..))))))...)..)))) (-76.30) ............................................AACAUUCAUUGUUGUCGGUGGGUU........................................................................................ 129 1 hsa-mir-181d_L01_M J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGUGGGUU........................................................................................ 54 1 hsa-mir-181d_L02 J1_ES_untr ............................................AACAUUCAUUGUUGUCGGUGGGU......................................................................................... 30 1 hsa-mir-181d_L03 J1_ES_untr ............................................AACAUUCAUUGUUGUCGGUGGGU......................................................................................... 24 1 hsa-mir-181d_L04 J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGUGGGUU........................................................................................ 8 1 hsa-mir-181d_L05 ES_Dicer ............................................AACAUUCAUUGUUGUCGGUGGGU......................................................................................... 7 1 hsa-mir-181d_L06 ES_Dicer ............................................AACAUUCAUUGUUGUCGGU............................................................................................. 5 1 hsa-mir-181d_L07 ES_Dicer ............................................AACAUUCAUUGUUGUCGGUGGG.......................................................................................... 4 1 hsa-mir-181d_L08 J1_ES_untr ............................................AACAUUCAUUGUUGUCGGUGGG.......................................................................................... 3 1 hsa-mir-181d_L09 ES_Dicer ............................................AACAUUCAUUGUUGUCGGUGG........................................................................................... 3 1 hsa-mir-181d_L10 J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGUGG........................................................................................... 2 1 hsa-mir-181d_L11 ES_Dicer ............................................AACAUUCAUUGUUGUCGGUGGG.......................................................................................... 2 1 hsa-mir-181d_L12 J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGUGG........................................................................................... 2 1 hsa-mir-181d_L13 J1_ES_untr ..............................................CAUUCAUUGUUGUCGGUGGGU......................................................................................... 1 1 hsa-mir-181d_L14 ES_Dicer ............................................AACAUUCAUUGUUGUCGGUGGGUUGU...................................................................................... 1 1 hsa-mir-181d_L15 J1_ES_demeth .............................................ACAUUCAUUGUUGUCGGUGGGU......................................................................................... 1 1 hsa-mir-181d_L16 J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGUGGGUUG....................................................................................... 1 1 hsa-mir-181d_L17 J1_ES_demeth .............................................ACAUUCAUUGUUGUCGGUGGGUU........................................................................................ 1 1 hsa-mir-181d_L18 J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGU............................................................................................. 1 1 hsa-mir-181d_L19 J1_ES_demeth ............................................AACAUUCAUUGUUGUCGGUGGGUUG....................................................................................... 1 1 hsa-mir-181d_L20 J1_ES_untr ............................................AACAUUCAUUGUUGUCGGUGGGUUG....................................................................................... 1 1 hsa-mir-181d_L21 ES_Dicer-DEL .......................................................................................CCACCGGGGGAUGAAUGUCA................................................. 2 1 hsa-mir-181d_R01*_M J1_ES_demeth ......................................................................................CCCACCGGGGGAUGAAUGUCA................................................. 1 1 hsa-mir-181d_R02* J1_ES_demeth ......................................................................................CCCACCGGGGGAUGAAUGUCAC................................................ 1 1 hsa-mir-181d_R03* J1_ES_demeth hsa-mir-182 chr7:129197439-129197588 - CUCCUGGGGGGAGCUGCUUGCCUCCCCCCGUUUUUGGCAAUGGUAGAACUCACACUGGUGAGGUAACAGGAUCCGGUGGUUCUAGACUUGCCAACUAUGGGGCGAGGACUCAGCCGGCACCCUGUGCAC .....(.((((.((((((..((((.((((((..(((((((.(.((((((...((((((..............))))))))))))..))))))))..)))))).))))....)).)))).)))).).... (-54.34) ................................UUUGGCAAUGGUAGAACUCACAC.......................................................................... 248 1 hsa-mir-182_L01_M J1_ES_untr ................................UUUGGCAAUGGUAGAACUCACAC.......................................................................... 230 1 hsa-mir-182_L02 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCACA........................................................................... 121 1 hsa-mir-182_L03 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCACA........................................................................... 78 1 hsa-mir-182_L04 J1_ES_untr ................................UUUGGCAAUGGUAGAACUCAC............................................................................ 50 1 hsa-mir-182_L05 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCAC............................................................................ 29 1 hsa-mir-182_L06 J1_ES_untr ................................UUUGGCAAUGGUAGAACUCACAC.......................................................................... 17 1 hsa-mir-182_L07 ES_Dicer ...............................UUUUGGCAAUGGUAGAACUCACAC.......................................................................... 9 1 hsa-mir-182_L08 J1_ES_untr .................................UUGGCAAUGGUAGAACUCACAC.......................................................................... 7 1 hsa-mir-182_L09 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCAC............................................................................ 6 1 hsa-mir-182_L10 ES_Dicer .................................UUGGCAAUGGUAGAACUCACA........................................................................... 6 1 hsa-mir-182_L11 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCA............................................................................. 5 1 hsa-mir-182_L12 J1_ES_untr .................................UUGGCAAUGGUAGAACUCAC............................................................................ 4 1 hsa-mir-182_L13 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCA............................................................................. 4 1 hsa-mir-182_L14 J1_ES_demeth ................................UUUGGCAAUGGUAGAACUCACACU......................................................................... 4 1 hsa-mir-182_L15 J1_ES_untr .................................UUGGCAAUGGUAGAACUCACA........................................................................... 4 1 hsa-mir-182_L16 J1_ES_untr ................................UUUGGCAAUGGUAGAACUCACA........................................................................... 3 1 hsa-mir-182_L17 ES_Dicer ................................UUUGGCAAUGGUAGAACUCACACU......................................................................... 2 1 hsa-mir-182_L18 J1_ES_demeth ...............................UUUUGGCAAUGGUAGAACUCAC............................................................................ 2 1 hsa-mir-182_L19 J1_ES_untr ...............................UUUUGGCAAUGGUAGAACUCACA........................................................................... 2 1 hsa-mir-182_L20 J1_ES_untr ................................UUUGGCAAUGGUAGAACUCACAC.......................................................................... 2 1 hsa-mir-182_L21 ES_Dicer-DEL .................................UUGGCAAUGGUAGAACUCACAC.......................................................................... 1 1 hsa-mir-182_L22 ES_Dicer ................................UUUGGCAAUGGUAGAACUCA............................................................................. 1 1 hsa-mir-182_L23 ES_Dicer ...................................GGCAAUGGUAGAACUCACAC.......................................................................... 1 1 hsa-mir-182_L24 ES_Dicer ................................UUUGGCAAUGGUAGAACUC.............................................................................. 1 1 hsa-mir-182_L25 J1_ES_demeth .................................UUGGCAAUGGUAGAACUCACAC.......................................................................... 1 1 hsa-mir-182_L26 J1_ES_untr ...........................................................................GUGGUUCUAGACUUGCCAACUA................................ 1 1 hsa-mir-182_R01*_M J1_ES_demeth ...........................................................................GUGGUUCUAGACUUGCCAACU................................. 1 1 hsa-mir-182_R02* J1_ES_demeth ............................................................................UGGUUCUAGACUUGCCAACU................................. 1 1 hsa-mir-182_R03* J1_ES_untr hsa-mir-1826 chr16:33872989-33873113 + GCAGGACAGAUUGAUCAUCGACACUUCGAACGCAAUUGCAGCCCGGGUUCCUCCCAGGGCUUUGCCUGUCUGAGCGUCGCUUGCCGAUCAGUAGUCCCCGGGGGU ...((((..(((((((..((((.(((.((..((((....((((((((.....))).)))))))))...)).))).))))......))))))).))))........ (-37.40) ...............CAUCGACACUUCGAACGCA....................................................................... 5 1 hsa-mir-1826_L01*_M J1_ES_untr ..............UCAUCGACACUUCGAACGCA....................................................................... 1 1 hsa-mir-1826_L02* J1_ES_demeth ...............CAUCGACACUUCGAACGCA....................................................................... 1 1 hsa-mir-1826_L03* J1_ES_demeth ...........UGAUCAUCGACACUUCGAA........................................................................... 1 1 hsa-mir-1826_L04* J1_ES_demeth ..........UUGAUCAUCGACACUUCGAACGC........................................................................ 1 1 hsa-mir-1826_L05* J1_ES_untr .........AUUGAUCAUCGACACUUCGAACGCA....................................................................... 1 1 hsa-mir-1826_L06* J1_ES_untr .............AUCAUCGACACUUCGAACG......................................................................... 1 1 hsa-mir-1826_L07* ES_Dicer-DEL ............GAUCAUCGACACUUCGAACG......................................................................... 1 1 hsa-mir-1826_L08* ES_Dicer-DEL ...............................................................GCCUGUCUGAGCGUCGCU........................ 99 1 hsa-mir-1826_R01_M ES_Dicer-DEL ...............................................................GCCUGUCUGAGCGUCGCUU....................... 26 1 hsa-mir-1826_R02 ES_Dicer-DEL ...............................................................GCCUGUCUGAGCGUCGCU........................ 18 1 hsa-mir-1826_R03 ES_Dicer ...............................................................GCCUGUCUGAGCGUCGCUU....................... 6 1 hsa-mir-1826_R04 ES_Dicer ...............................................................GCCUGUCUGAGCGUCGCU........................ 3 1 hsa-mir-1826_R05 J1_ES_demeth ...............................................................GCCUGUCUGAGCGUCGCUUG...................... 1 1 hsa-mir-1826_R06 ES_Dicer-DEL hsa-mir-183 chr7:129201961-129202110 - GGUCGGCAGGCCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGAGGGCCUCCGGA ..((((.(((((.(...(((.((.(((((((((((.((((((..(((((..(((((((((((......)))..)))))))))))))....)))))).))))))))).))....)))))..)))))))))). (-56.70) ....................................UAUGGCACUGGUAGAAUUCACU......................................................................... 408 1 hsa-mir-183_L01_M J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUCACU......................................................................... 213 1 hsa-mir-183_L02 J1_ES_untr ....................................UAUGGCACUGGUAGAAUUCACUG........................................................................ 209 1 hsa-mir-183_L03 J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUCACUG........................................................................ 117 1 hsa-mir-183_L04 J1_ES_untr .....................................AUGGCACUGGUAGAAUUCACU......................................................................... 112 1 hsa-mir-183_L05 J1_ES_demeth .....................................AUGGCACUGGUAGAAUUCACUG........................................................................ 70 1 hsa-mir-183_L06 J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUCAC.......................................................................... 53 1 hsa-mir-183_L07 J1_ES_demeth .....................................AUGGCACUGGUAGAAUUCACUG........................................................................ 40 1 hsa-mir-183_L08 J1_ES_untr .....................................AUGGCACUGGUAGAAUUCACU......................................................................... 32 1 hsa-mir-183_L09 J1_ES_untr .....................................AUGGCACUGGUAGAAUUCACUGU....................................................................... 31 1 hsa-mir-183_L10 J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUCACUGU....................................................................... 31 1 hsa-mir-183_L11 J1_ES_untr ....................................UAUGGCACUGGUAGAAUUCACU......................................................................... 27 1 hsa-mir-183_L12 ES_Dicer ....................................UAUGGCACUGGUAGAAUUCACUGU....................................................................... 24 1 hsa-mir-183_L13 J1_ES_demeth .....................................AUGGCACUGGUAGAAUUCACUGU....................................................................... 21 1 hsa-mir-183_L14 J1_ES_untr ....................................UAUGGCACUGGUAGAAUUCAC.......................................................................... 20 1 hsa-mir-183_L15 J1_ES_untr ....................................UAUGGCACUGGUAGAAUUCA........................................................................... 17 1 hsa-mir-183_L16 J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUCACUG........................................................................ 16 1 hsa-mir-183_L17 ES_Dicer .....................................AUGGCACUGGUAGAAUUCAC.......................................................................... 11 1 hsa-mir-183_L18 J1_ES_demeth .....................................AUGGCACUGGUAGAAUUCACUG........................................................................ 10 1 hsa-mir-183_L19 ES_Dicer ....................................UAUGGCACUGGUAGAAUUCA........................................................................... 6 1 hsa-mir-183_L20 J1_ES_untr .....................................AUGGCACUGGUAGAAUUCACU......................................................................... 5 1 hsa-mir-183_L21 ES_Dicer .........................................CACUGGUAGAAUUCACUG........................................................................ 5 1 hsa-mir-183_L22 J1_ES_demeth .....................................AUGGCACUGGUAGAAUUCACUGU....................................................................... 2 1 hsa-mir-183_L23 ES_Dicer ......................................UGGCACUGGUAGAAUUCACUG........................................................................ 2 1 hsa-mir-183_L24 ES_Dicer ...................................GUAUGGCACUGGUAGAAUUCACU......................................................................... 2 1 hsa-mir-183_L25 J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUCAC.......................................................................... 2 1 hsa-mir-183_L26 ES_Dicer-DEL ....................................UAUGGCACUGGUAGAAUUCA........................................................................... 1 1 hsa-mir-183_L27 ES_Dicer .....................................AUGGCACUGGUAGAAUUC............................................................................ 1 1 hsa-mir-183_L28 J1_ES_demeth .........................................CACUGGUAGAAUUCACUGU....................................................................... 1 1 hsa-mir-183_L29 J1_ES_demeth ....................................UAUGGCACUGGUAGAAUUC............................................................................ 1 1 hsa-mir-183_L30 J1_ES_demeth ..................................UGUAUGGCACUGGUAGAAUUCACU......................................................................... 1 1 hsa-mir-183_L31 J1_ES_untr .....................................AUGGCACUGGUAGAAUUCAC.......................................................................... 1 1 hsa-mir-183_L32 J1_ES_untr ....................................UAUGGCACUGGUAGAAUUCA........................................................................... 1 1 hsa-mir-183_L33 ES_Dicer-DEL ....................................UAUGGCACUGGUAGAAUUCACU......................................................................... 1 1 hsa-mir-183_L34 ES_Dicer-DEL ............................................................................UGAAUUACCGAAGGGCCAUAA.................................. 255 1 hsa-mir-183_R01*_M J1_ES_demeth ............................................................................UGAAUUACCGAAGGGCCAUAAA................................. 126 1 hsa-mir-183_R02* J1_ES_demeth ............................................................................UGAAUUACCGAAGGGCCAUAA.................................. 67 1 hsa-mir-183_R03* J1_ES_untr ............................................................................UGAAUUACCGAAGGGCCAUA................................... 45 1 hsa-mir-183_R04* J1_ES_demeth ............................................................................UGAAUUACCGAAGGGCCAUAAA................................. 39 1 hsa-mir-183_R05* J1_ES_untr ...........................................................................GUGAAUUACCGAAGGGCCAUAA.................................. 33 1 hsa-mir-183_R06* J1_ES_demeth ...........................................................................GUGAAUUACCGAAGGGCCAUAA.................................. 13 1 hsa-mir-183_R07* J1_ES_untr ............................................................................UGAAUUACCGAAGGGCCAUAA.................................. 9 1 hsa-mir-183_R08* ES_Dicer ............................................................................UGAAUUACCGAAGGGCCAU.................................... 9 1 hsa-mir-183_R09* J1_ES_demeth ............................................................................UGAAUUACCGAAGGGCCAUA................................... 8 1 hsa-mir-183_R10* J1_ES_untr ............................................................................UGAAUUACCGAAGGGCCAUAAA................................. 5 1 hsa-mir-183_R11* ES_Dicer ...........................................................................GUGAAUUACCGAAGGGCCAUA................................... 5 1 hsa-mir-183_R12* J1_ES_demeth ...........................................................................GUGAAUUACCGAAGGGCCAUAAA................................. 4 1 hsa-mir-183_R13* J1_ES_untr ............................................................................UGAAUUACCGAAGGGCCAUAAACA............................... 3 1 hsa-mir-183_R14* J1_ES_demeth ...........................................................................GUGAAUUACCGAAGGGCCAUAAA................................. 2 1 hsa-mir-183_R15* J1_ES_demeth ...........................................................................GUGAAUUACCGAAGGGCCAUA................................... 2 1 hsa-mir-183_R16* J1_ES_untr ............................................................................UGAAUUACCGAAGGGCCAU.................................... 2 1 hsa-mir-183_R17* J1_ES_untr ...........................................................................GUGAAUUACCGAAGGGCCAUAAA................................. 1 1 hsa-mir-183_R18* ES_Dicer ............................................................................UGAAUUACCGAAGGGCCAUA................................... 1 1 hsa-mir-183_R19* ES_Dicer ............................................................................UGAAUUACCGAAGGGCCAUAAAC................................ 1 1 hsa-mir-183_R20* ES_Dicer ........................................................................UCAGUGAAUUACCGAAGGGCCAUAA.................................. 1 1 hsa-mir-183_R21* J1_ES_demeth ........................................................................UCAGUGAAUUACCGAAGGGCCAUAAA................................. 1 1 hsa-mir-183_R22* J1_ES_untr hsa-mir-184 chr15:77289165-77289288 + CUUUGCCGGCCAGUCACGUCCCCUUAUCACUUUUCCAGCCCAGCUUUGUGACUGUAAGUGUUGGACGGAGAACUGAUAAGGGUAGGUGAUUGACACUCACAGCCU .......((((((((((.(.(((((((((.((((((.(.(((((((((......)))).))))).))))))).))))))))).).))))))).........))). (-39.90) .............................................................UGGACGGAGAACUGAUAAGGG....................... 5 1 hsa-mir-184_R01_M J1_ES_demeth .............................................................UGGACGGAGAACUGAUAAGGGU...................... 2 1 hsa-mir-184_R02 J1_ES_demeth .............................................................UGGACGGAGAACUGAUAAGGGU...................... 1 1 hsa-mir-184_R03 J1_ES_untr hsa-mir-185 chr22:18400642-18400763 + GGCUCGAGCAGGGGGCGAGGGAUUGGAGAGAAAGGCAGUUCCUGAUGGUCCCCUCCCCAGGGGCUGGCUUUCCUCUGGUCCUUCCCUCCCAAUGACCGCGU ((.(((....(((((.(((((((..(((.(((((.(((((((((..((......)).))))))))).))))))))..))))))))))))...))))).... (-55.00) .......................UGGAGAGAAAGGCAGUUCCUGA........................................................ 34 1 hsa-mir-185_L01_M J1_ES_demeth .......................UGGAGAGAAAGGCAGUUCCUGA........................................................ 19 1 hsa-mir-185_L02 J1_ES_untr .......................UGGAGAGAAAGGCAGUUCCUGA........................................................ 6 1 hsa-mir-185_L03 ES_Dicer .......................UGGAGAGAAAGGCAGUUCCUGAU....................................................... 4 1 hsa-mir-185_L04 J1_ES_demeth .......................UGGAGAGAAAGGCAGUUCCUG......................................................... 1 1 hsa-mir-185_L05 J1_ES_untr .......................UGGAGAGAAAGGCAGUUCCU.......................................................... 1 1 hsa-mir-185_L06 J1_ES_demeth .......................UGGAGAGAAAGGCAGUUCCUG......................................................... 1 1 hsa-mir-185_L07 J1_ES_demeth ..........................................................AGGGGCUGGCUUUCCUCUGGU...................... 3 1 hsa-mir-185_R01*_M J1_ES_demeth ..........................................................AGGGGCUGGCUUUCCUCUGGU...................... 1 1 hsa-mir-185_R02* ES_Dicer ..........................................................AGGGGCUGGCUUUCCUCUGGU...................... 1 1 hsa-mir-185_R03* J1_ES_untr hsa-mir-186 chr1:71305882-71306007 - AUUUUUUCAUUGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCUAAAUUCCUUC ...........(((((.(((((((((((((((((.(((((.((((((..............))))))))))).))))))))))))))))))))))........... (-41.24) ........................CAAAGAAUUCUCCUUUUGGGCUU........................................................... 16 1 hsa-mir-186_L01_M J1_ES_demeth ........................CAAAGAAUUCUCCUUUUGGGCU............................................................ 11 1 hsa-mir-186_L02 J1_ES_demeth ........................CAAAGAAUUCUCCUUUUGGGC............................................................. 9 1 hsa-mir-186_L03 J1_ES_demeth ........................CAAAGAAUUCUCCUUUUGGGCUUU.......................................................... 9 1 hsa-mir-186_L04 J1_ES_demeth .......................CCAAAGAAUUCUCCUUUUGGGCU............................................................ 9 1 hsa-mir-186_L05 J1_ES_demeth ........................CAAAGAAUUCUCCUUUUGGGCUU........................................................... 6 1 hsa-mir-186_L06 J1_ES_untr ........................CAAAGAAUUCUCCUUUUGGGCU............................................................ 5 1 hsa-mir-186_L07 J1_ES_untr ........................CAAAGAAUUCUCCUUUUGGGCUU........................................................... 2 1 hsa-mir-186_L08 ES_Dicer .......................CCAAAGAAUUCUCCUUUUGGGCUUU.......................................................... 2 1 hsa-mir-186_L09 J1_ES_demeth ........................CAAAGAAUUCUCCUUUUGGGC............................................................. 1 1 hsa-mir-186_L10 ES_Dicer .......................CCAAAGAAUUCUCCUUUUGGGCU............................................................ 1 1 hsa-mir-186_L11 J1_ES_untr .......................CCAAAGAAUUCUCCUUUUGGGC............................................................. 1 1 hsa-mir-186_L12 J1_ES_untr ........................CAAAGAAUUCUCCUUUUGGGC............................................................. 1 1 hsa-mir-186_L13 J1_ES_untr .........................AAAGAAUUCUCCUUUUGGGCUU........................................................... 1 1 hsa-mir-186_L14 J1_ES_untr ........................CAAAGAAUUCUCCUUUUGGG.............................................................. 1 1 hsa-mir-186_L15 J1_ES_demeth .......................CCAAAGAAUUCUCCUUUUGGGC............................................................. 1 1 hsa-mir-186_L16 J1_ES_demeth ........................CAAAGAAUUCUCCUUUUGG............................................................... 1 1 hsa-mir-186_L17 J1_ES_demeth .........................AAAGAAUUCUCCUUUUGGGCUU........................................................... 1 1 hsa-mir-186_L18 J1_ES_demeth hsa-mir-187 chr18:31738759-31738907 - AGGUGCUGCAGGUCGGGCUCACCAUGACACAGUGUGAGACCUCGGGCUACAACACAGGACCCGGGCGCUGCUCUGACCCCUCGUGUCUUGUGUUGCAGCCGGAGGGACGCAGGUCCGCAGCAGAGCCU (((((((((.(..(...((((((........).))))).((((.((((.(((((((((((.((((.((......).).)).)).))))))))))).)))).))))......)..).)))))...)))) (-58.70) ................................................................................UCGUGUCUUGUGUUGCAGCCGG.......................... 8 1 hsa-mir-187_R01_M J1_ES_demeth ................................................................................UCGUGUCUUGUGUUGCAGCCGGA......................... 3 1 hsa-mir-187_R02 J1_ES_demeth .................................................................................CGUGUCUUGUGUUGCAGCCGGA......................... 2 1 hsa-mir-187_R03 J1_ES_demeth ................................................................................UCGUGUCUUGUGUUGCAGCCG........................... 1 1 hsa-mir-187_R04 J1_ES_demeth ................................................................................UCGUGUCUUGUGUUGCAGCCGGAG........................ 1 1 hsa-mir-187_R05 J1_ES_demeth ................................................................................UCGUGUCUUGUGUUGCAGCCGG.......................... 1 1 hsa-mir-187_R06 J1_ES_untr ................................................................................UCGUGUCUUGUGUUGCAGCCGGA......................... 1 1 hsa-mir-187_R07 J1_ES_untr ................................................................................UCGUGUCUUGUGUUGCAGCCG........................... 1 1 hsa-mir-187_R08 J1_ES_untr hsa-mir-188 chrX:49654829-49654954 + GCCCUUCCCUGCUCCCUCUCUCACAUCCCUUGCAUGGUGGAGGGUGAGCUUUCUGAAAACCCCUCCCACAUGCAGGGUUUGCAGGAUGGCGAGCCUCAGCUUUCC ..........((((((..(((..((..(((((((((..((((((....(.....).....))))))..)))))))))..))..))).)).))))........... (-39.80) .......................CAUCCCUUGCAUGGUGGAGGGU............................................................ 3 1 hsa-mir-188_L01*_M ES_Dicer .......................CAUCCCUUGCAUGGUGGAG............................................................... 1 1 hsa-mir-188_L02* ES_Dicer .......................CAUCCCUUGCAUGGUGGAGGG............................................................. 1 1 hsa-mir-188_L03* ES_Dicer ..............................................................CUCCCACAUGCAGGGUUUGCA...................... 4 1 hsa-mir-188_R01_M ES_Dicer ..............................................................CUCCCACAUGCAGGGUUUGCA...................... 1 1 hsa-mir-188_R02 J1_ES_untr hsa-mir-18a chr13:90800986-90801096 + AGUGCUUUUUGUUCUAAGGUGCAUCUAGUGCAGAUAGUGAAGUAGAUUAGCAUCUACUGCCCUAAGUGCUCCUUCUGGCAUAAGAAGUUA ...(((((((((.((((((.(((..(((.((((.(((((..(.....)..)).))))))).)))..))).)))..))).))))))))).. (-27.30) ..............UAAGGUGCAUCUAGUGCAGAUAG..................................................... 269 1 hsa-mir-18a_L01_M J1_ES_untr ..............UAAGGUGCAUCUAGUGCAGAUAG..................................................... 248 1 hsa-mir-18a_L02 J1_ES_demeth ..............UAAGGUGCAUCUAGUGCAGAUA...................................................... 148 1 hsa-mir-18a_L03 J1_ES_untr ..............UAAGGUGCAUCUAGUGCAGAUA...................................................... 110 1 hsa-mir-18a_L04 J1_ES_demeth ..............UAAGGUGCAUCUAGUGCAGAUAG..................................................... 100 1 hsa-mir-18a_L05 ES_Dicer ..............UAAGGUGCAUCUAGUGCAGAUA...................................................... 80 1 hsa-mir-18a_L06 ES_Dicer ..............UAAGGUGCAUCUAGUGCAGAU....................................................... 77 1 hsa-mir-18a_L07 J1_ES_untr ..............UAAGGUGCAUCUAGUGCAGAU....................................................... 70 1 hsa-mir-18a_L08 ES_Dicer ..............UAAGGUGCAUCUAGUGCAGAU....................................................... 49 1 hsa-mir-18a_L09 J1_ES_demeth ..............UAAGGUGCAUCUAGUGCAGA........................................................ 8 1 hsa-mir-18a_L10 J1_ES_demeth ..............UAAGGUGCAUCUAGUGCAGAUAGU.................................................... 7 1 hsa-mir-18a_L11 J1_ES_untr ..............UAAGGUGCAUCUAGUGCAGAUAGU.................................................... 6 1 hsa-mir-18a_L12 J1_ES_demeth ..............UAAGGUGCAUCUAGUGCAGAUAGU.................................................... 4 1 hsa-mir-18a_L13 ES_Dicer ..............UAAGGUGCAUCUAGUGCAGA........................................................ 3 1 hsa-mir-18a_L14 J1_ES_untr ..............UAAGGUGCAUCUAGUGCAGA........................................................ 2 1 hsa-mir-18a_L15 ES_Dicer ...............AAGGUGCAUCUAGUGCAGAUA...................................................... 2 1 hsa-mir-18a_L16 ES_Dicer ................AGGUGCAUCUAGUGCAGAUAG..................................................... 1 1 hsa-mir-18a_L17 ES_Dicer ..............UAAGGUGCAUCUAGUGCAG......................................................... 1 2 hsa-mir-18a_L18 J1_ES_demeth ..................GUGCAUCUAGUGCAGAUA...................................................... 1 1 hsa-mir-18a_L19 J1_ES_demeth .......................................................ACUGCCCUAAGUGCUCCUUCUGG............ 5 1 hsa-mir-18a_R01*_M J1_ES_untr ........................................................CUGCCCUAAGUGCUCCUUCUGGC........... 3 1 hsa-mir-18a_R02* J1_ES_untr .......................................................ACUGCCCUAAGUGCUCCUUCUGG............ 3 1 hsa-mir-18a_R03* J1_ES_demeth .......................................................ACUGCCCUAAGUGCUCCUUCUGGC........... 3 1 hsa-mir-18a_R04* J1_ES_demeth .......................................................ACUGCCCUAAGUGCUCCUUCU.............. 2 1 hsa-mir-18a_R05* ES_Dicer .......................................................ACUGCCCUAAGUGCUCCUUCUGG............ 2 1 hsa-mir-18a_R06* ES_Dicer .......................................................ACUGCCCUAAGUGCUCCUUCUGGC........... 2 1 hsa-mir-18a_R07* J1_ES_untr ........................................................CUGCCCUAAGUGCUCCUUCUGGC........... 2 1 hsa-mir-18a_R08* J1_ES_demeth .......................................................ACUGCCCUAAGUGCUCCUUCUG............. 1 1 hsa-mir-18a_R09* ES_Dicer .......................................................ACUGCCCUAAGUGCUCCUUCU.............. 1 1 hsa-mir-18a_R10* J1_ES_untr .......................................................ACUGCCCUAAGUGCUCCUUCUG............. 1 1 hsa-mir-18a_R11* J1_ES_untr .......................................................ACUGCCCUAAGUGCUCCUUC............... 1 1 hsa-mir-18a_R12* J1_ES_demeth .......................................................ACUGCCCUAAGUGCUCCUUCU.............. 1 1 hsa-mir-18a_R13* J1_ES_demeth hsa-mir-18b chrX:133131717-133131827 - UCUUAUAAUGUGUCUCUUGUGUUAAGGUGCAUCUAGUGCAGUUAGUGAAGCAGCUUAGAAUCUACUGCCCUAAAUGCCCCUUCUGGCACAGGCUGCC ...........((..((((((((((((.((((.(((.(((((..((.(((...)))...))..))))).))).)))).)))..)))))))))..)). (-28.80) ......................UAAGGUGCAUCUAGUGCAG........................................................ 1 2 hsa-mir-18b_L01*_M J1_ES_demeth ..............................................................UACUGCCCUAAAUGCCCCUUCU............. 3 1 hsa-mir-18b_R01_M J1_ES_untr ..............................................................UACUGCCCUAAAUGCCCCUUCU............. 1 1 hsa-mir-18b_R02 J1_ES_demeth hsa-mir-190 chr15:60903189-60903313 + UGCCUUUUCUGCAGGCCUCUGUGUGAUAUGUUUGAUAUAUUAGGUUGUUAUUUAAUCCAACUAUAUAUCAAACAUAUUCCUACAGUGUCUUGCCCUGUCUCCGG ..........(((((.(.(((((..(((((((((((((((..(((((..........))))))))))))))))))))..).)))).).)))))........... (-32.50) .......................UGAUAUGUUUGAUAUAUUAGGUU.......................................................... 22 1 hsa-mir-190_L01_M J1_ES_untr .......................UGAUAUGUUUGAUAUAUUAGGUU.......................................................... 21 1 hsa-mir-190_L02 J1_ES_demeth .......................UGAUAUGUUUGAUAUAUUAGGUUG......................................................... 5 1 hsa-mir-190_L03 J1_ES_untr .......................UGAUAUGUUUGAUAUAUUAGGUU.......................................................... 4 1 hsa-mir-190_L04 ES_Dicer .......................UGAUAUGUUUGAUAUAUUAGGU........................................................... 3 1 hsa-mir-190_L05 ES_Dicer .......................UGAUAUGUUUGAUAUAUUAGGU........................................................... 3 1 hsa-mir-190_L06 J1_ES_demeth ......................GUGAUAUGUUUGAUAUAUUAG............................................................. 1 1 hsa-mir-190_L07 ES_Dicer ......................GUGAUAUGUUUGAUAUAUUAGGU........................................................... 1 1 hsa-mir-190_L08 J1_ES_untr .......................UGAUAUGUUUGAUAUAUUAGGU........................................................... 1 1 hsa-mir-190_L09 J1_ES_untr ........................GAUAUGUUUGAUAUAUUAGGUU.......................................................... 1 1 hsa-mir-190_L10 J1_ES_demeth hsa-mir-190b chr1:152432745-152432863 - CUCUCCUGCCUGCUUCUGUGUGAUAUGUUUGAUAUUGGGUUGUUUAAUUAGGAACCAACUAAAUGUCAAACAUAUUCUUACAGCAGCAGGUGAUUCAG .......(((((((.(((((.(((((((((((((((.((((((((......))).))))).)))))))))))))))..))))).)))))))....... (-40.60) ....................UGAUAUGUUUGAUAUUGGGUUG........................................................ 1 1 hsa-mir-190b_L01_M J1_ES_demeth hsa-mir-191 chr3:49033035-49033166 - CCCCCGCCAACGGCUGGACAGCGGGCAACGGAAUCCCAAAAGCAGCUGUUGUCUCCAGAGCAUUCCAGCUGCGCUUGGAUUUCGUCCCCUGCUCUCCUGCCUGAGCAGCGC .....((((..(((.(((.((((((..(((((((((.((..(((((((..((((....)).))..)))))))..)))))))))))..)))))).))).))))).))..... (-51.20) .........................CAACGGAAUCCCAAAAGCAGCU................................................................ 160 1 hsa-mir-191_L01_M J1_ES_demeth .........................CAACGGAAUCCCAAAAGCAGCU................................................................ 116 1 hsa-mir-191_L02 J1_ES_untr .........................CAACGGAAUCCCAAAAGCAGCUG............................................................... 97 1 hsa-mir-191_L03 J1_ES_demeth .........................CAACGGAAUCCCAAAAGCAGCUGU.............................................................. 97 1 hsa-mir-191_L04 J1_ES_demeth .........................CAACGGAAUCCCAAAAGCAGCUGU.............................................................. 84 1 hsa-mir-191_L05 J1_ES_untr .........................CAACGGAAUCCCAAAAGCAGCUG............................................................... 66 1 hsa-mir-191_L06 J1_ES_untr .........................CAACGGAAUCCCAAAAGCAGC................................................................. 49 1 hsa-mir-191_L07 J1_ES_demeth .........................CAACGGAAUCCCAAAAGCAGC................................................................. 22 1 hsa-mir-191_L08 J1_ES_untr .........................CAACGGAAUCCCAAAAGCAG.................................................................. 18 1 hsa-mir-191_L09 J1_ES_demeth .........................CAACGGAAUCCCAAAAGCAGCU................................................................ 17 1 hsa-mir-191_L10 ES_Dicer .........................CAACGGAAUCCCAAAAGCAGCUG............................................................... 16 1 hsa-mir-191_L11 ES_Dicer .........................CAACGGAAUCCCAAAAGCAGCUGUU............................................................. 7 1 hsa-mir-191_L12 J1_ES_demeth .........................CAACGGAAUCCCAAAAGCAGCUGU.............................................................. 5 1 hsa-mir-191_L13 ES_Dicer .........................CAACGGAAUCCCAAAAGCAG.................................................................. 3 1 hsa-mir-191_L14 ES_Dicer .........................CAACGGAAUCCCAAAAGCAG.................................................................. 3 1 hsa-mir-191_L15 J1_ES_untr .........................CAACGGAAUCCCAAAAGCAGCUGUU............................................................. 3 1 hsa-mir-191_L16 J1_ES_untr .........................CAACGGAAUCCCAAAAGCAGC................................................................. 2 1 hsa-mir-191_L17 ES_Dicer ..........................AACGGAAUCCCAAAAGCAGCUGU.............................................................. 2 1 hsa-mir-191_L18 J1_ES_demeth ..........................AACGGAAUCCCAAAAGCAGCU................................................................ 1 1 hsa-mir-191_L19 J1_ES_demeth ........................GCAACGGAAUCCCAAAAGCAGCU................................................................ 1 1 hsa-mir-191_L20 J1_ES_demeth ..........................AACGGAAUCCCAAAAGCAGCUG............................................................... 1 1 hsa-mir-191_L21 J1_ES_demeth .............................GGAAUCCCAAAAGCAGCUG............................................................... 1 1 hsa-mir-191_L22 J1_ES_demeth ..........................AACGGAAUCCCAAAAGCAGCUGU.............................................................. 1 1 hsa-mir-191_L23 J1_ES_untr .........................................................................................UGCUCUCCUGCCUGAGCAGC.. 1 1 hsa-mir-191_R01*_M ES_Dicer-DEL ................................................UUGUCUCCAGAGCAUUCCA............................................ 3 1 hsa-mir-191_O01 J1_ES_demeth ................................................UUGUCUCCAGAGCAUUCCA............................................ 1 1 hsa-mir-191_O02 J1_ES_untr hsa-mir-192 chr11:64415165-64415314 - UCGGUGGGCUGCCGAGACCGAGUGCACAGGGCUCUGACCUAUGAAUUGACAGCCAGUGCUCUCGUCUCCCCUCUGGCUGCCAAUUCCAUAGGUCACAGGUAUGUUCGCCUCAAUGCCAGCCACCAGGAC ..(((((.(((.((.....(((.(((((.(.((.((((((((((((((.(((((((................))))))).))))).))))))))).)).).)))..)))))..)).))))))))..... (-50.79) .................................CUGACCUAUGAAUUGACAGCC........................................................................... 6 1 hsa-mir-192_L01_M ES_Dicer ..................................UGACCUAUGAAUUGACAGCCAG......................................................................... 4 1 hsa-mir-192_L02 J1_ES_demeth .................................CUGACCUAUGAAUUGACAGCCA.......................................................................... 3 1 hsa-mir-192_L03 ES_Dicer ..................................UGACCUAUGAAUUGACAGCCAGU........................................................................ 3 1 hsa-mir-192_L04 J1_ES_demeth .................................CUGACCUAUGAAUUGACAGCCA.......................................................................... 3 1 hsa-mir-192_L05 J1_ES_demeth ..................................UGACCUAUGAAUUGACAGCCAGU........................................................................ 2 1 hsa-mir-192_L06 J1_ES_untr ..................................UGACCUAUGAAUUGACAGCCAG......................................................................... 2 1 hsa-mir-192_L07 J1_ES_untr .................................CUGACCUAUGAAUUGACAGC............................................................................ 2 1 hsa-mir-192_L08 J1_ES_demeth .................................CUGACCUAUGAAUUGACAGCCA.......................................................................... 1 1 hsa-mir-192_L09 J1_ES_untr ..................................UGACCUAUGAAUUGACAGCCA.......................................................................... 1 1 hsa-mir-192_L10 J1_ES_demeth ............................................................................CUGCCAAUUCCAUAGGUCACAG............................... 1 1 hsa-mir-192_R01*_M ES_Dicer ............................................................................CUGCCAAUUCCAUAGGUCACAG............................... 1 1 hsa-mir-192_R02* J1_ES_demeth hsa-mir-193a chr17:26911108-26911235 + CGCACCCCGAACUCCGAGGAUGGGAGCUGAGGGCUGGGUCUUUGCGGGCGAGAUGAGGGUGUCGGAUCAACUGGCCUACAAAGUCCCAGUUCUCGGCCCCCGGGACCAGCGU (((..((((...((....)).(((.(((((((((((((.(((((..(((.((.(((..........))).)).)))..))))).))))))))))))))))))))....))). (-57.70) ....................................................................AACUGGCCUACAAAGUCCCAGU...................... 77 1 hsa-mir-193a_R01_M ES_Dicer ....................................................................AACUGGCCUACAAAGUCCCAGU...................... 21 1 hsa-mir-193a_R02 J1_ES_demeth ....................................................................AACUGGCCUACAAAGUCCCA........................ 7 1 hsa-mir-193a_R03 ES_Dicer ....................................................................AACUGGCCUACAAAGUCCCAGUU..................... 3 1 hsa-mir-193a_R04 ES_Dicer ....................................................................AACUGGCCUACAAAGUCCCAGU...................... 2 1 hsa-mir-193a_R05 J1_ES_untr hsa-mir-194-1 chr1:218358102-218358226 - UAUAUGUUUAAUGGUGUUAUCAAGUGUAACAGCAACUCCAUGUGGACUGUGUACCAAUUUCCAGUGGAGAUGCUGUUACUUUUGAUGGUUACCAACUUGCUACA .....((....(((((..((((((.(((((((((.((((((.((((..((......)).)))))))))).))))))))).))))))..).))))....)).... (-38.40) ........................UGUAACAGCAACUCCAUGUGGA.......................................................... 35 2 hsa-mir-194-1_L01_M J1_ES_demeth ........................UGUAACAGCAACUCCAUGUGGA.......................................................... 32 2 hsa-mir-194-1_L02 J1_ES_untr ........................UGUAACAGCAACUCCAUGUGG........................................................... 7 2 hsa-mir-194-1_L03 J1_ES_demeth ........................UGUAACAGCAACUCCAUGUGGA.......................................................... 5 2 hsa-mir-194-1_L04 ES_Dicer ........................UGUAACAGCAACUCCAUGUGGAC......................................................... 2 1 hsa-mir-194-1_L05 J1_ES_demeth ........................UGUAACAGCAACUCCAUGUGG........................................................... 1 2 hsa-mir-194-1_L06 J1_ES_untr hsa-mir-194-2 chr11:64415383-64415507 - CCCCGGUCUCCAAUUGGUUCCCGCCCCCUGUAACAGCAACUCCAUGUGGAAGUGCCCACUGGUUCCAGUGGGGCUGCUGUUAUCUGGGGCGAGGGCCAGUACCCACGA ....(((.....((((((((.((((((..(((((((((..(((....)))....(((((((....)))))))..)))))))))..)))))).)))))))))))..... (-54.60) ............................UGUAACAGCAACUCCAUGUGGAA......................................................... 70 1 hsa-mir-194-2_L01_M J1_ES_demeth ............................UGUAACAGCAACUCCAUGUGGAA......................................................... 43 1 hsa-mir-194-2_L02 J1_ES_untr ............................UGUAACAGCAACUCCAUGUGGA.......................................................... 35 2 hsa-mir-194-2_L03 J1_ES_demeth ............................UGUAACAGCAACUCCAUGUGGA.......................................................... 32 2 hsa-mir-194-2_L04 J1_ES_untr ............................UGUAACAGCAACUCCAUGUGGAA......................................................... 7 1 hsa-mir-194-2_L05 ES_Dicer ............................UGUAACAGCAACUCCAUGUGG........................................................... 7 2 hsa-mir-194-2_L06 J1_ES_demeth ............................UGUAACAGCAACUCCAUGUGGA.......................................................... 5 2 hsa-mir-194-2_L07 ES_Dicer ............................UGUAACAGCAACUCCAUGUGG........................................................... 1 2 hsa-mir-194-2_L08 J1_ES_untr hsa-mir-195 chr17:6861638-6861764 - GCCCACACCCAGCUUCCCUGGCUCUAGCAGCACAGAAAUAUUGGCACAGGGAAGCGAGUCUGCCAAUAUUGGCUGUGCUGCUCCAGGCAGGGUGGUGAAAACUACC .....((((......(((((.((..((((((((((.((((((((((..............))))))))))..))))))))))..)).))))).))))......... (-47.64) ........................UAGCAGCACAGAAAUAUUGGCA............................................................ 30 1 hsa-mir-195_L01_M J1_ES_untr ........................UAGCAGCACAGAAAUAUUGGC............................................................. 6 1 hsa-mir-195_L02 ES_Dicer ........................UAGCAGCACAGAAAUAUUGGCA............................................................ 6 1 hsa-mir-195_L03 J1_ES_demeth ........................UAGCAGCACAGAAAUAUUGGC............................................................. 5 1 hsa-mir-195_L04 J1_ES_demeth ........................UAGCAGCACAGAAAUAUUGGC............................................................. 4 1 hsa-mir-195_L05 J1_ES_untr ........................UAGCAGCACAGAAAUAUUGGCA............................................................ 3 1 hsa-mir-195_L06 ES_Dicer ........................UAGCAGCACAGAAAUAUUGG.............................................................. 2 1 hsa-mir-195_L07 J1_ES_demeth ........................UAGCAGCACAGAAAUAUUGG.............................................................. 1 1 hsa-mir-195_L08 ES_Dicer hsa-mir-196a-1 chr17:44064831-44064940 - GAACUGCUGAGUGAAUUAGGUAGUUUCAUGUUGUUGGGCCUGGGUUUCUGAACACAACAACAUUAAACCACCCGAUUCACGGCAGUUAC .(((((((..((((((..(((.((((.((((((((((..(.........)..).))))))))).)))).)))..))))))))))))).. (-35.90) ................UAGGUAGUUUCAUGUUGUUGGG................................................... 11 2 hsa-mir-196a-1_L01_M J1_ES_demeth ................UAGGUAGUUUCAUGUUGUUGG.................................................... 3 2 hsa-mir-196a-1_L02 J1_ES_demeth ................UAGGUAGUUUCAUGUUGUUGGG................................................... 2 2 hsa-mir-196a-1_L03 J1_ES_untr ................UAGGUAGUUUCAUGUUGUUGGG................................................... 1 2 hsa-mir-196a-1_L04 ES_Dicer ................UAGGUAGUUUCAUGUUGUU...................................................... 1 2 hsa-mir-196a-1_L05 J1_ES_demeth hsa-mir-196a-2 chr12:52671769-52671918 + CUCCCGCCCUGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGCCCCAACCCAC .....(((((...((...(((((((.((((((((((((((((((.((((((((((.(..(...)..).)))))))))).))))))))))))))))))...)))))))..))...))))).......... (-56.80) .................................UAGGUAGUUUCAUGUUGUUGGG.......................................................................... 11 2 hsa-mir-196a-2_L01_M J1_ES_demeth .................................UAGGUAGUUUCAUGUUGUUGGGA......................................................................... 5 1 hsa-mir-196a-2_L02 J1_ES_demeth .................................UAGGUAGUUUCAUGUUGUUGG........................................................................... 3 2 hsa-mir-196a-2_L03 J1_ES_demeth .................................UAGGUAGUUUCAUGUUGUUGGG.......................................................................... 2 2 hsa-mir-196a-2_L04 J1_ES_untr .................................UAGGUAGUUUCAUGUUGUUGGG.......................................................................... 1 2 hsa-mir-196a-2_L05 ES_Dicer .................................UAGGUAGUUUCAUGUUGUUGGGA......................................................................... 1 1 hsa-mir-196a-2_L06 J1_ES_untr .................................UAGGUAGUUUCAUGUUGUU............................................................................. 1 2 hsa-mir-196a-2_L07 J1_ES_demeth hsa-mir-196b chr7:27175604-27175727 - CAGCACCAGAACUGGUCGGUGAUUUAGGUAGUUUCCUGUUGUUGGGAUCCACCUUUCUCUCGACAGCACGACACUGCCUUCAUUACUUCAGUUGAAAUCGUCU .........((((((..((((((..(((((((.((.(((((((((((..........))))))))))).)).)))))))..)))))))))))).......... (-36.20) ........................UAGGUAGUUUCCUGUUGUUGG.......................................................... 2 1 hsa-mir-196b_L01_M J1_ES_demeth ........................UAGGUAGUUUCCUGUUGUUGGG......................................................... 1 1 hsa-mir-196b_L02 J1_ES_demeth ........................UAGGUAGUUUCCUGUUGUUGGGA........................................................ 1 1 hsa-mir-196b_L03 J1_ES_demeth hsa-mir-199a-1 chr19:10789082-10789192 - AGCCGGCCCCGCCAACCCAGUGUUCAGACUACCUGUUCAGGAGGCUCUCAAUGUGUACAGUAGUCUGCACAUUGGUUAGGCUGGGCUUGGG ..(((((((.(((...(((((((.((((((((.(((.((.(((...)))....)).))))))))))).)))))))...))).)))).))). (-43.30) ...............CCCAGUGUUCAGACUACCUGUU...................................................... 1 2 hsa-mir-199a-1_L01*_M J1_ES_demeth ...............CCCAGUGUUCAGACUACCUGUUC..................................................... 1 2 hsa-mir-199a-1_L02* J1_ES_demeth ........................................................ACAGUAGUCUGCACAUUGGUUA............. 8 3 hsa-mir-199a-1_R01_M J1_ES_demeth .......................................................UACAGUAGUCUGCACAUUGGUU.............. 4 3 hsa-mir-199a-1_R02 J1_ES_demeth .......................................................UACAGUAGUCUGCACAUUGGUU.............. 3 3 hsa-mir-199a-1_R03 J1_ES_untr .........................................................CAGUAGUCUGCACAUUGGUUA............. 3 3 hsa-mir-199a-1_R04 J1_ES_demeth ........................................................ACAGUAGUCUGCACAUUGGUU.............. 2 3 hsa-mir-199a-1_R05 J1_ES_untr ........................................................ACAGUAGUCUGCACAUUGGUU.............. 2 3 hsa-mir-199a-1_R06 J1_ES_demeth ........................................................ACAGUAGUCUGCACAUUGGUUA............. 1 3 hsa-mir-199a-1_R07 ES_Dicer ........................................................ACAGUAGUCUGCACAUUGGUUA............. 1 3 hsa-mir-199a-1_R08 J1_ES_untr ...........................................................GUAGUCUGCACAUUGGUUA............. 1 3 hsa-mir-199a-1_R09 J1_ES_demeth hsa-mir-199a-2 chr1:170380278-170380427 - AGUACAUAGAAGGAAGCUUCUGGAGAUCCUGCUCCGUCGCCCCAGUGUUCAGACUACCUGUUCAGGACAAUGCCGUUGUACAGUAGUCUGCACAUUGGUUAGACUGGGCAAGGGAGAGCAACGCCAUGG .((...((((((....))))))....((((((((.(((...(((((((.((((((((.(((...((......)).....))))))))))).)))))))...))).)))).))))...)).......... (-47.40) ........................................CCCAGUGUUCAGACUACCUGUU................................................................... 1 2 hsa-mir-199a-2_L01*_M J1_ES_demeth ........................................CCCAGUGUUCAGACUACCUGUUC.................................................................. 1 2 hsa-mir-199a-2_L02* J1_ES_demeth ...............................................................................ACAGUAGUCUGCACAUUGGUUA............................ 8 3 hsa-mir-199a-2_R01_M J1_ES_demeth ..............................................................................UACAGUAGUCUGCACAUUGGUU............................. 4 3 hsa-mir-199a-2_R02 J1_ES_demeth ..............................................................................UACAGUAGUCUGCACAUUGGUU............................. 3 3 hsa-mir-199a-2_R03 J1_ES_untr ................................................................................CAGUAGUCUGCACAUUGGUUA............................ 3 3 hsa-mir-199a-2_R04 J1_ES_demeth ...............................................................................ACAGUAGUCUGCACAUUGGUU............................. 2 3 hsa-mir-199a-2_R05 J1_ES_untr ...............................................................................ACAGUAGUCUGCACAUUGGUU............................. 2 3 hsa-mir-199a-2_R06 J1_ES_demeth ...............................................................................ACAGUAGUCUGCACAUUGGUUA............................ 1 3 hsa-mir-199a-2_R07 ES_Dicer ...............................................................................ACAGUAGUCUGCACAUUGGUUA............................ 1 3 hsa-mir-199a-2_R08 J1_ES_untr ..................................................................................GUAGUCUGCACAUUGGUUA............................ 1 3 hsa-mir-199a-2_R09 J1_ES_demeth hsa-mir-199b chr9:130046801-130046950 - GCCUGGAUGGACCAGAGGACACCUCCACUCCGUCUACCCAGUGUUUAGACUAUCUGUUCAGGACUCCCAAAUUGUACAGUAGUCUGCACAUUGGUUAGGCUGGGCUGGGUUAGACCCUCGGCACCGCCGCCA ...((((((((...((((...))))...)))))))).(((((((.(((((((.((((.((((....))....)).))))))))))).)))))))...(((.((((((((.......)))))).))))).... (-51.70) ...........................................................................ACAGUAGUCUGCACAUUGGUUA................................... 8 3 hsa-mir-199b_R01_M J1_ES_demeth ..........................................................................UACAGUAGUCUGCACAUUGGUU.................................... 4 3 hsa-mir-199b_R02 J1_ES_demeth ..........................................................................UACAGUAGUCUGCACAUUGGUU.................................... 3 3 hsa-mir-199b_R03 J1_ES_untr ............................................................................CAGUAGUCUGCACAUUGGUUA................................... 3 3 hsa-mir-199b_R04 J1_ES_demeth ...........................................................................ACAGUAGUCUGCACAUUGGUU.................................... 2 3 hsa-mir-199b_R05 J1_ES_untr ...........................................................................ACAGUAGUCUGCACAUUGGUU.................................... 2 3 hsa-mir-199b_R06 J1_ES_demeth ...........................................................................ACAGUAGUCUGCACAUUGGUUA................................... 1 3 hsa-mir-199b_R07 ES_Dicer ...........................................................................ACAGUAGUCUGCACAUUGGUUA................................... 1 3 hsa-mir-199b_R08 J1_ES_untr ..............................................................................GUAGUCUGCACAUUGGUUA................................... 1 3 hsa-mir-199b_R09 J1_ES_demeth hsa-mir-19a chr13:90801126-90801247 + AGUUUUUGUUUGCAGUCCUCUGUUAGUUUUGCAUAGUUGCACUACAAGAAGAAUGUAGUUGUGCAAAUCUAUGCAAAACUGAUGGUGGCCUGCUAUUUCCUUC ...........((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).)))).......... (-40.30) .......................UAGUUUUGCAUAGUUGCACUAC.......................................................... 11 1 hsa-mir-19a_L01*_M J1_ES_untr .......................UAGUUUUGCAUAGUUGCACUAC.......................................................... 11 1 hsa-mir-19a_L02* J1_ES_demeth ........................AGUUUUGCAUAGUUGCACUAC.......................................................... 10 1 hsa-mir-19a_L03* J1_ES_demeth .......................UAGUUUUGCAUAGUUGCACUAC.......................................................... 8 1 hsa-mir-19a_L04* ES_Dicer ........................AGUUUUGCAUAGUUGCACUAC.......................................................... 4 1 hsa-mir-19a_L05* J1_ES_untr .......................UAGUUUUGCAUAGUUGCACUACA......................................................... 3 1 hsa-mir-19a_L06* J1_ES_untr ........................AGUUUUGCAUAGUUGCACUAC.......................................................... 2 1 hsa-mir-19a_L07* ES_Dicer ........................AGUUUUGCAUAGUUGCACUACA......................................................... 1 1 hsa-mir-19a_L08* ES_Dicer .......................UAGUUUUGCAUAGUUGCACUA........................................................... 1 1 hsa-mir-19a_L09* ES_Dicer ......................UUAGUUUUGCAUAGUUGCACUACA......................................................... 1 1 hsa-mir-19a_L10* J1_ES_untr .......................UAGUUUUGCAUAGUUGCACUA........................................................... 1 1 hsa-mir-19a_L11* J1_ES_demeth ........................AGUUUUGCAUAGUUGCACUACA......................................................... 1 1 hsa-mir-19a_L12* J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACUGA..................... 1409 1 hsa-mir-19a_R01_M J1_ES_untr ...........................................................UGUGCAAAUCUAUGCAAAACUGA..................... 927 1 hsa-mir-19a_R02 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACUG...................... 207 1 hsa-mir-19a_R03 J1_ES_untr ...........................................................UGUGCAAAUCUAUGCAAAACUGA..................... 197 1 hsa-mir-19a_R04 ES_Dicer ...........................................................UGUGCAAAUCUAUGCAAAACU....................... 160 1 hsa-mir-19a_R05 J1_ES_untr ...........................................................UGUGCAAAUCUAUGCAAAACU....................... 135 1 hsa-mir-19a_R06 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACUG...................... 128 1 hsa-mir-19a_R07 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACUG...................... 78 1 hsa-mir-19a_R08 ES_Dicer ..........................................................UUGUGCAAAUCUAUGCAAAACUGA..................... 78 1 hsa-mir-19a_R09 J1_ES_untr ..........................................................UUGUGCAAAUCUAUGCAAAACUGA..................... 67 1 hsa-mir-19a_R10 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACUGAU.................... 49 1 hsa-mir-19a_R11 J1_ES_untr ...........................................................UGUGCAAAUCUAUGCAAAACUGAU.................... 48 1 hsa-mir-19a_R12 J1_ES_demeth ..........................................................UUGUGCAAAUCUAUGCAAAACUG...................... 21 1 hsa-mir-19a_R13 J1_ES_untr ..........................................................UUGUGCAAAUCUAUGCAAAACU....................... 21 1 hsa-mir-19a_R14 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAAC........................ 17 1 hsa-mir-19a_R15 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACU....................... 15 1 hsa-mir-19a_R16 ES_Dicer ..........................................................UUGUGCAAAUCUAUGCAAAACU....................... 14 1 hsa-mir-19a_R17 J1_ES_untr ..........................................................UUGUGCAAAUCUAUGCAAAACUG...................... 9 1 hsa-mir-19a_R18 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAAC........................ 8 1 hsa-mir-19a_R19 J1_ES_untr ..........................................................UUGUGCAAAUCUAUGCAAAACUGA..................... 7 1 hsa-mir-19a_R20 ES_Dicer ..........................................................UUGUGCAAAUCUAUGCAAAACUG...................... 7 1 hsa-mir-19a_R21 ES_Dicer ..........................................................UUGUGCAAAUCUAUGCAAAAC........................ 5 1 hsa-mir-19a_R22 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAACUGAU.................... 4 1 hsa-mir-19a_R23 ES_Dicer ...........................................................UGUGCAAAUCUAUGCAAAAC........................ 3 1 hsa-mir-19a_R24 ES_Dicer ..........................................................UUGUGCAAAUCUAUGCAAAACUGAU.................... 3 1 hsa-mir-19a_R25 J1_ES_demeth .............................................................UGCAAAUCUAUGCAAAACUGA..................... 2 1 hsa-mir-19a_R26 ES_Dicer ..........................................................UUGUGCAAAUCUAUGCAAAACU....................... 2 1 hsa-mir-19a_R27 ES_Dicer ............................................................GUGCAAAUCUAUGCAAAACUGA..................... 2 1 hsa-mir-19a_R28 J1_ES_untr ...........................................................UGUGCAAAUCUAUGCAAA.......................... 2 1 hsa-mir-19a_R29 J1_ES_demeth ...........................................................UGUGCAAAUCUAUGCAAAA......................... 2 1 hsa-mir-19a_R30 J1_ES_demeth ............................................................GUGCAAAUCUAUGCAAAACUGA..................... 1 1 hsa-mir-19a_R31 ES_Dicer .............................................................UGCAAAUCUAUGCAAAACUGA..................... 1 1 hsa-mir-19a_R32 J1_ES_untr ..........................................................UUGUGCAAAUCUAUGCAAAAC........................ 1 1 hsa-mir-19a_R33 J1_ES_untr ...........................................................UGUGCAAAUCUAUGCAAAA......................... 1 1 hsa-mir-19a_R34 J1_ES_untr ............................................................GUGCAAAUCUAUGCAAAACUGA..................... 1 1 hsa-mir-19a_R35 J1_ES_demeth .....................................................UGUAGUUGUGCAAAUCUAUGCAAAACUGA..................... 1 1 hsa-mir-19a_R36 J1_ES_demeth .............................................................UGCAAAUCUAUGCAAAACU....................... 1 1 hsa-mir-19a_R37 J1_ES_demeth ............................................................GUGCAAAUCUAUGCAAAACU....................... 1 1 hsa-mir-19a_R38 J1_ES_demeth hsa-mir-19b-1 chr13:90801427-90801553 + GUUACUGAACACUGUUCUAUGGUUAGUUUUGCAGGUUUGCAUCCAGCUGUGUGAUAUUCUGCUGUGCAAAUCCAUGCAAAACUGACUGUGGUAGUGAAAAGUCUGU ...(((...(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))...))).... (-40.92) ........................AGUUUUGCAGGUUUGCAUCCAGC........................................................... 26 1 hsa-mir-19b-1_L01*_M J1_ES_untr ........................AGUUUUGCAGGUUUGCAUCCAGC........................................................... 17 1 hsa-mir-19b-1_L02* J1_ES_demeth ........................AGUUUUGCAGGUUUGCAUCCAG............................................................ 2 1 hsa-mir-19b-1_L03* J1_ES_demeth ........................AGUUUUGCAGGUUUGCAUCCAG............................................................ 1 1 hsa-mir-19b-1_L04* ES_Dicer ........................AGUUUUGCAGGUUUGCAUCC.............................................................. 1 1 hsa-mir-19b-1_L05* J1_ES_demeth ........................AGUUUUGCAGGUUUGCAUCCA............................................................. 1 1 hsa-mir-19b-1_L06* J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAAACUGA..................... 10072 2 hsa-mir-19b-1_R01_M J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAACUGA..................... 6945 2 hsa-mir-19b-1_R02 J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAAACUG...................... 1611 2 hsa-mir-19b-1_R03 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAACU....................... 1004 2 hsa-mir-19b-1_R04 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAACUG...................... 911 2 hsa-mir-19b-1_R05 J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAAACUGA..................... 901 2 hsa-mir-19b-1_R06 ES_Dicer ..............................................................UGUGCAAAUCCAUGCAAAACU....................... 845 2 hsa-mir-19b-1_R07 J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAAACUG...................... 453 2 hsa-mir-19b-1_R08 ES_Dicer ..............................................................UGUGCAAAUCCAUGCAAAACU....................... 162 2 hsa-mir-19b-1_R09 ES_Dicer ..............................................................UGUGCAAAUCCAUGCAAAAC........................ 71 2 hsa-mir-19b-1_R10 J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAAAC........................ 62 2 hsa-mir-19b-1_R11 J1_ES_untr .............................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 56 2 hsa-mir-19b-1_R12 J1_ES_untr .............................................................CUGUGCAAAUCCAUGCAAAACUG...................... 35 2 hsa-mir-19b-1_R13 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAAC........................ 24 2 hsa-mir-19b-1_R14 ES_Dicer ..............................................................UGUGCAAAUCCAUGCAAAA......................... 21 2 hsa-mir-19b-1_R15 J1_ES_demeth .............................................................CUGUGCAAAUCCAUGCAAAACU....................... 18 2 hsa-mir-19b-1_R16 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAACUGAC.................... 17 1 hsa-mir-19b-1_R17 J1_ES_untr .............................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 15 2 hsa-mir-19b-1_R18 J1_ES_demeth .............................................................CUGUGCAAAUCCAUGCAAAACUG...................... 11 2 hsa-mir-19b-1_R19 J1_ES_demeth .............................................................CUGUGCAAAUCCAUGCAAAACU....................... 7 2 hsa-mir-19b-1_R20 J1_ES_demeth ................................................................UGCAAAUCCAUGCAAAACUGA..................... 7 2 hsa-mir-19b-1_R21 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAA......................... 6 2 hsa-mir-19b-1_R22 ES_Dicer ................................................................UGCAAAUCCAUGCAAAACUGA..................... 5 2 hsa-mir-19b-1_R23 J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAAA......................... 5 2 hsa-mir-19b-1_R24 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAACUGAC.................... 4 1 hsa-mir-19b-1_R25 J1_ES_demeth ..............................................................UGUGCAAAUCCAUGCAAA.......................... 4 2 hsa-mir-19b-1_R26 J1_ES_demeth .............................................................CUGUGCAAAUCCAUGCAAAACUG...................... 3 2 hsa-mir-19b-1_R27 ES_Dicer .............................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 2 2 hsa-mir-19b-1_R28 ES_Dicer ................................................................UGCAAAUCCAUGCAAAACUGA..................... 2 2 hsa-mir-19b-1_R29 ES_Dicer ...............................................................GUGCAAAUCCAUGCAAAACUG...................... 2 2 hsa-mir-19b-1_R30 J1_ES_demeth .............................................................CUGUGCAAAUCCAUGCAAAACU....................... 1 2 hsa-mir-19b-1_R31 ES_Dicer ..............................................................UGUGCAAAUCCAUGCAAA.......................... 1 2 hsa-mir-19b-1_R32 ES_Dicer ...............................................................GUGCAAAUCCAUGCAAAACUG...................... 1 2 hsa-mir-19b-1_R33 ES_Dicer ..............................................................UGUGCAAAUCCAUGCAAA.......................... 1 2 hsa-mir-19b-1_R34 J1_ES_untr ...............................................................GUGCAAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-1_R35 J1_ES_untr ...............................................................GUGCAAAUCCAUGCAAAACU....................... 1 2 hsa-mir-19b-1_R36 J1_ES_untr ..............................................................UGUGCAAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-1_R37 ES_Dicer-DEL ..............................................................UGUGCAAAUCCAUGCAAAAC........................ 1 2 hsa-mir-19b-1_R38 ES_Dicer-DEL hsa-mir-19b-2 chrX:133131347-133131482 - GAUGGAGAGAAUAUUCAAAGACAUUGCUACUUACAAUUAGUUUUGCAGGUUUGCAUUUCAGCGUAUAUAUGUAUAUGUGGCUGUGCAAAUCCAUGCAAAACUGAUUGUGAUAAUGUGUGCUUCCU ...((((.((....))..(.((((((....((((((((((((((((((((((((((....(((((((....)))))))....))))))).)).))))))))))))))))))))))).)..)))). (-44.10) .................................................................................UGUGCAAAUCCAUGCAAAACUGA..................... 10072 2 hsa-mir-19b-2_R01_M J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAACUGA..................... 6945 2 hsa-mir-19b-2_R02 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUG...................... 1611 2 hsa-mir-19b-2_R03 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAACU....................... 1004 2 hsa-mir-19b-2_R04 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAACUG...................... 911 2 hsa-mir-19b-2_R05 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUGA..................... 901 2 hsa-mir-19b-2_R06 ES_Dicer .................................................................................UGUGCAAAUCCAUGCAAAACU....................... 845 2 hsa-mir-19b-2_R07 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUG...................... 453 2 hsa-mir-19b-2_R08 ES_Dicer .................................................................................UGUGCAAAUCCAUGCAAAACU....................... 162 2 hsa-mir-19b-2_R09 ES_Dicer .................................................................................UGUGCAAAUCCAUGCAAAAC........................ 71 2 hsa-mir-19b-2_R10 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUGAU.................... 69 1 hsa-mir-19b-2_R11 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAAC........................ 62 2 hsa-mir-19b-2_R12 J1_ES_untr ................................................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 56 2 hsa-mir-19b-2_R13 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAACUGAU.................... 53 1 hsa-mir-19b-2_R14 J1_ES_untr ................................................................................CUGUGCAAAUCCAUGCAAAACUG...................... 35 2 hsa-mir-19b-2_R15 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAAC........................ 24 2 hsa-mir-19b-2_R16 ES_Dicer .................................................................................UGUGCAAAUCCAUGCAAAA......................... 21 2 hsa-mir-19b-2_R17 J1_ES_demeth ................................................................................CUGUGCAAAUCCAUGCAAAACU....................... 18 2 hsa-mir-19b-2_R18 J1_ES_untr ................................................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 15 2 hsa-mir-19b-2_R19 J1_ES_demeth ................................................................................CUGUGCAAAUCCAUGCAAAACUG...................... 11 2 hsa-mir-19b-2_R20 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUGAU.................... 7 1 hsa-mir-19b-2_R21 ES_Dicer ................................................................................CUGUGCAAAUCCAUGCAAAACU....................... 7 2 hsa-mir-19b-2_R22 J1_ES_demeth ...................................................................................UGCAAAUCCAUGCAAAACUGA..................... 7 2 hsa-mir-19b-2_R23 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAA......................... 6 2 hsa-mir-19b-2_R24 ES_Dicer ...................................................................................UGCAAAUCCAUGCAAAACUGA..................... 5 2 hsa-mir-19b-2_R25 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAA......................... 5 2 hsa-mir-19b-2_R26 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAA.......................... 4 2 hsa-mir-19b-2_R27 J1_ES_demeth ................................................................................CUGUGCAAAUCCAUGCAAAACUG...................... 3 2 hsa-mir-19b-2_R28 ES_Dicer ................................................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 2 2 hsa-mir-19b-2_R29 ES_Dicer ...................................................................................UGCAAAUCCAUGCAAAACUGA..................... 2 2 hsa-mir-19b-2_R30 ES_Dicer ..................................................................................GUGCAAAUCCAUGCAAAACUG...................... 2 2 hsa-mir-19b-2_R31 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUGAUU................... 2 1 hsa-mir-19b-2_R32 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAAACUGAUU................... 2 1 hsa-mir-19b-2_R33 J1_ES_untr ..................................................................................GUGCAAAUCCAUGCAAAACUGAU.................... 1 1 hsa-mir-19b-2_R34 ES_Dicer ................................................................................CUGUGCAAAUCCAUGCAAAACU....................... 1 2 hsa-mir-19b-2_R35 ES_Dicer .................................................................................UGUGCAAAUCCAUGCAAA.......................... 1 2 hsa-mir-19b-2_R36 ES_Dicer ..................................................................................GUGCAAAUCCAUGCAAAACUG...................... 1 2 hsa-mir-19b-2_R37 ES_Dicer ................................................................................CUGUGCAAAUCCAUGCAAAACUGAU.................... 1 1 hsa-mir-19b-2_R38 J1_ES_demeth .................................................................................UGUGCAAAUCCAUGCAAA.......................... 1 2 hsa-mir-19b-2_R39 J1_ES_untr ................................................................................CUGUGCAAAUCCAUGCAAAACUGAU.................... 1 1 hsa-mir-19b-2_R40 J1_ES_untr ..................................................................................GUGCAAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-2_R41 J1_ES_untr ..................................................................................GUGCAAAUCCAUGCAAAACU....................... 1 2 hsa-mir-19b-2_R42 J1_ES_untr .................................................................................UGUGCAAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-2_R43 ES_Dicer-DEL .................................................................................UGUGCAAAUCCAUGCAAAAC........................ 1 2 hsa-mir-19b-2_R44 ES_Dicer-DEL hsa-mir-200a chr1:1093086-1093215 + ACGUCCCUCCCGGGCCCCUGUGAGCAUCUUACCGGACAGUGCUGGAUUUCCCAGCUUGACUCUAACACUGUCUGGUAACGAUGUUCAAAGGUGACCCGCCGCUCGCCGGGGACA ..((((((..(((((((((.(((((((((((((((((((((((((.....)))))...........)))))))))))).)))))))).))).).......)))))..)))))). (-56.41) ........................CAUCUUACCGGACAGUGCUGGA.................................................................... 12 1 hsa-mir-200a_L01*_M J1_ES_untr ........................CAUCUUACCGGACAGUGCUG...................................................................... 3 1 hsa-mir-200a_L02* ES_Dicer ........................CAUCUUACCGGACAGUGCUGGA.................................................................... 2 1 hsa-mir-200a_L03* ES_Dicer ........................CAUCUUACCGGACAGUGCUGGAU................................................................... 1 1 hsa-mir-200a_L04* J1_ES_untr ........................CAUCUUACCGGACAGUGCUGGA.................................................................... 1 1 hsa-mir-200a_L05* J1_ES_demeth ..............................................................UAACACUGUCUGGUAACGAUGUU............................. 362 1 hsa-mir-200a_R01_M J1_ES_untr ..............................................................UAACACUGUCUGGUAACGAUGUU............................. 328 1 hsa-mir-200a_R02 J1_ES_demeth ..............................................................UAACACUGUCUGGUAACGAUGUU............................. 89 1 hsa-mir-200a_R03 ES_Dicer ..............................................................UAACACUGUCUGGUAACGAUGU.............................. 58 1 hsa-mir-200a_R04 J1_ES_demeth ..............................................................UAACACUGUCUGGUAACGAU................................ 54 1 hsa-mir-200a_R05 ES_Dicer ..............................................................UAACACUGUCUGGUAACGAUGU.............................. 53 1 hsa-mir-200a_R06 J1_ES_untr ..............................................................UAACACUGUCUGGUAACGAUGU.............................. 31 1 hsa-mir-200a_R07 ES_Dicer ..............................................................UAACACUGUCUGGUAACGAUG............................... 8 1 hsa-mir-200a_R08 ES_Dicer ..................................................................ACUGUCUGGUAACGAUGUU............................. 5 1 hsa-mir-200a_R09 J1_ES_demeth ..............................................................UAACACUGUCUGGUAACGA................................. 3 1 hsa-mir-200a_R10 ES_Dicer ..............................................................UAACACUGUCUGGUAACGAU................................ 3 1 hsa-mir-200a_R11 J1_ES_untr ..............................................................UAACACUGUCUGGUAACGAUG............................... 2 1 hsa-mir-200a_R12 J1_ES_untr ..............................................................UAACACUGUCUGGUAACGAU................................ 2 1 hsa-mir-200a_R13 J1_ES_demeth ...............................................................AACACUGUCUGGUAACGAUGUU............................. 2 1 hsa-mir-200a_R14 J1_ES_demeth ...............................................................AACACUGUCUGGUAACGAUGUU............................. 1 1 hsa-mir-200a_R15 ES_Dicer ..................................................................ACUGUCUGGUAACGAUGUU............................. 1 1 hsa-mir-200a_R16 J1_ES_untr ..............................................................UAACACUGUCUGGUAACGA................................. 1 1 hsa-mir-200a_R17 J1_ES_demeth ..............................................................UAACACUGUCUGGUAACGAUG............................... 1 1 hsa-mir-200a_R18 J1_ES_demeth hsa-mir-200b chr1:1092327-1092461 + GGGCGGCCCCCGGACCCAGCUCGGGCAGCCGUGGCCAUCUUACUGGGCAGCAUUGGAUGGAGUCAGGUCUCUAAUACUGCCUGGUAAUGAUGACGGCGGAGCCCUGCACGCAGCGACCGG (((...)))((((.....(((((.((((((((.(.((((((((..(((((.((((((.((.......)))))))).)))))..)))).)))).).))))....)))).)).)))..)))) (-50.20) ...................................CAUCUUACUGGGCAGCAUUGGA............................................................... 19 1 hsa-mir-200b_L01*_M J1_ES_untr ...................................CAUCUUACUGGGCAGCAUUGGA............................................................... 9 1 hsa-mir-200b_L02* J1_ES_demeth ...................................CAUCUUACUGGGCAGCAUUGG................................................................ 8 1 hsa-mir-200b_L03* J1_ES_demeth ...................................CAUCUUACUGGGCAGCAUUGG................................................................ 5 1 hsa-mir-200b_L04* J1_ES_untr ...................................CAUCUUACUGGGCAGCAUUGG................................................................ 2 1 hsa-mir-200b_L05* ES_Dicer ...................................CAUCUUACUGGGCAGCAUUG................................................................. 2 1 hsa-mir-200b_L06* J1_ES_demeth ....................................AUCUUACUGGGCAGCAUUGGA............................................................... 2 1 hsa-mir-200b_L07* J1_ES_demeth ...................................CAUCUUACUGGGCAGCAUUGGAU.............................................................. 1 1 hsa-mir-200b_L08* J1_ES_untr ....................................AUCUUACUGGGCAGCAUUGGAU.............................................................. 1 1 hsa-mir-200b_L09* J1_ES_demeth .......................................................................UAAUACUGCCUGGUAAUGAUGAC.......................... 420 1 hsa-mir-200b_R01_M J1_ES_untr .......................................................................UAAUACUGCCUGGUAAUGAUGA........................... 255 1 hsa-mir-200b_R02 J1_ES_untr .......................................................................UAAUACUGCCUGGUAAUGAUGAC.......................... 250 1 hsa-mir-200b_R03 J1_ES_demeth .......................................................................UAAUACUGCCUGGUAAUGAUGA........................... 219 1 hsa-mir-200b_R04 J1_ES_demeth .......................................................................UAAUACUGCCUGGUAAUGAUGAC.......................... 103 1 hsa-mir-200b_R05 ES_Dicer .......................................................................UAAUACUGCCUGGUAAUGAUGA........................... 81 1 hsa-mir-200b_R06 ES_Dicer .......................................................................UAAUACUGCCUGGUAAUGAUG............................ 66 1 hsa-mir-200b_R07 J1_ES_demeth .......................................................................UAAUACUGCCUGGUAAUGAUG............................ 27 1 hsa-mir-200b_R08 J1_ES_untr .......................................................................UAAUACUGCCUGGUAAUGAUG............................ 15 1 hsa-mir-200b_R09 ES_Dicer .......................................................................UAAUACUGCCUGGUAAUGAU............................. 8 1 hsa-mir-200b_R10 J1_ES_demeth .......................................................................UAAUACUGCCUGGUAAUGAU............................. 3 1 hsa-mir-200b_R11 J1_ES_untr .......................................................................UAAUACUGCCUGGUAAUGAU............................. 2 1 hsa-mir-200b_R12 ES_Dicer ......................................................................CUAAUACUGCCUGGUAAUGAUGAC.......................... 2 1 hsa-mir-200b_R13 ES_Dicer ........................................................................AAUACUGCCUGGUAAUGAUGAC.......................... 2 1 hsa-mir-200b_R14 J1_ES_demeth ..........................................................................UACUGCCUGGUAAUGAUGAC.......................... 1 1 hsa-mir-200b_R15 ES_Dicer ........................................................................AAUACUGCCUGGUAAUGAUGAC.......................... 1 1 hsa-mir-200b_R16 J1_ES_untr .........................................................................AUACUGCCUGGUAAUGAUGA........................... 1 1 hsa-mir-200b_R17 J1_ES_untr .........................................................................AUACUGCCUGGUAAUGAUGAC.......................... 1 1 hsa-mir-200b_R18 J1_ES_demeth ............................................................................CUGCCUGGUAAUGAUGAC.......................... 1 1 hsa-mir-200b_R19 J1_ES_demeth hsa-mir-200c chr12:6943103-6943210 + GGGCGGGGGCCCUCGUCUUACCCAGCAGUGUUUGGGUGCGGUUGGGAGUCUCUAAUACUGCCGGGUAAUGAUGGAGGCCCCUGUCCC (((((((((((..((((((((((.((((((((.(((.((........))))).)))))))).)))))).))))..))))))))))). (-56.20) .............CGUCUUACCCAGCAGUGUUUGG.................................................... 1 1 hsa-mir-200c_L01*_M J1_ES_untr ....................................................UAAUACUGCCGGGUAAUGAUGGA............ 60 1 hsa-mir-200c_R01_M J1_ES_untr ....................................................UAAUACUGCCGGGUAAUGAUGGA............ 26 1 hsa-mir-200c_R02 J1_ES_demeth ....................................................UAAUACUGCCGGGUAAUGAUGGA............ 19 1 hsa-mir-200c_R03 ES_Dicer ....................................................UAAUACUGCCGGGUAAUGAUGG............. 19 1 hsa-mir-200c_R04 J1_ES_demeth ....................................................UAAUACUGCCGGGUAAUGAUGG............. 6 1 hsa-mir-200c_R05 J1_ES_untr ....................................................UAAUACUGCCGGGUAAUGAUG.............. 5 1 hsa-mir-200c_R06 J1_ES_demeth ....................................................UAAUACUGCCGGGUAAUGAUGG............. 2 1 hsa-mir-200c_R07 ES_Dicer ....................................................UAAUACUGCCGGGUAAUGAUG.............. 2 1 hsa-mir-200c_R08 ES_Dicer ....................................................UAAUACUGCCGGGUAAUGAUG.............. 2 1 hsa-mir-200c_R09 J1_ES_untr ....................................................UAAUACUGCCGGGUAAUGAU............... 2 1 hsa-mir-200c_R10 J1_ES_demeth ...................................................CUAAUACUGCCGGGUAAUGAUG.............. 1 1 hsa-mir-200c_R11 ES_Dicer ....................................................UAAUACUGCCGGGUAAUGAU............... 1 1 hsa-mir-200c_R12 ES_Dicer ...................................................CUAAUACUGCCGGGUAAUGAUGG............. 1 1 hsa-mir-200c_R13 J1_ES_demeth hsa-mir-203 chr14:103653475-103653624 + GAACCGACGGUGUUGGGGACUCGCGCGCUGGGUCCAGUGGUUCUUAACAGUUCAACAGUUCUGUAGCGCAAUUGUGAAAUGUUUAGGACCACUAGACCCGGCGGGCGCGGCGACAGCGACGGAGCGUCC ...(((.((.(((((....(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).))))).)).)))....... (-63.50) .........................................................................GUGAAAUGUUUAGGACCACUAGA................................. 5 1 hsa-mir-203_R01_M J1_ES_untr ..........................................................................UGAAAUGUUUAGGACCACUAG.................................. 2 1 hsa-mir-203_R02 J1_ES_demeth .........................................................................GUGAAAUGUUUAGGACCACU.................................... 1 1 hsa-mir-203_R03 J1_ES_demeth ..........................................................................UGAAAUGUUUAGGACCACUAGA................................. 1 1 hsa-mir-203_R04 J1_ES_demeth ........................................................................UGUGAAAUGUUUAGGACCACUA................................... 1 1 hsa-mir-203_R05 J1_ES_demeth .........................................................................GUGAAAUGUUUAGGACCACUAG.................................. 1 1 hsa-mir-203_R06 J1_ES_untr hsa-mir-204 chr9:72614691-72614840 - GCGUACCCAUGGCUACAGUCUUUCUUCAUGUGACUCGUGGACUUCCCUUUGUCAUCCUAUGCCUGAGAAUAUAUGAAGGAGGCUGGGAAGGCAAAGGGACGUUCAAUUGUCAUCACUGGCAUCUUUUUU ((........(((....))).........(((((...(((((.((((((((((.(((((.((((...............))))))))).)))))))))).)))))...))))).....))......... (-44.06) ..........................................UUCCCUUUGUCAUCCUAUGCCUG................................................................ 1 1 hsa-mir-204_L01_M J1_ES_demeth hsa-mir-205 chr1:207672081-207672230 + CCCUCUGAGAAAAAGAUCCUCAGACAAUCCAUGUGCUUCUCUUGUCCUUCAUUCCACCGGAGUCUGUCUCAUACCCAACCAGAUUUCAGUGGAGUGAAGUUCAGGAGGCAUGGAGCUGACAACCAUGAGGCC .((((((.((......)).((((....(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))).))))....)).)))).. (-52.72) ............................................UCCUUCAUUCCACCGGAGUCUG.................................................................. 52 1 hsa-mir-205_L01_M J1_ES_untr ............................................UCCUUCAUUCCACCGGAGUCU................................................................... 51 1 hsa-mir-205_L02 J1_ES_demeth ............................................UCCUUCAUUCCACCGGAGUCUG.................................................................. 32 1 hsa-mir-205_L03 J1_ES_demeth ............................................UCCUUCAUUCCACCGGAGUCUG.................................................................. 28 1 hsa-mir-205_L04 ES_Dicer ............................................UCCUUCAUUCCACCGGAGUCUGU................................................................. 24 1 hsa-mir-205_L05 J1_ES_untr ............................................UCCUUCAUUCCACCGGAGUCU................................................................... 21 1 hsa-mir-205_L06 J1_ES_untr ............................................UCCUUCAUUCCACCGGAGUCUGU................................................................. 18 1 hsa-mir-205_L07 J1_ES_demeth ............................................UCCUUCAUUCCACCGGAGUCU................................................................... 13 1 hsa-mir-205_L08 ES_Dicer ............................................UCCUUCAUUCCACCGGAGUC.................................................................... 3 1 hsa-mir-205_L09 J1_ES_demeth ............................................UCCUUCAUUCCACCGGAGUCUGU................................................................. 2 1 hsa-mir-205_L10 ES_Dicer ............................................UCCUUCAUUCCACCGGAGU..................................................................... 1 1 hsa-mir-205_L11 J1_ES_demeth ............................................UCCUUCAUUCCACCGGAGUC.................................................................... 1 1 hsa-mir-205_L12 J1_ES_untr ............................................UCCUUCAUUCCACCGGAGUC.................................................................... 1 1 hsa-mir-205_L13 ES_Dicer-DEL hsa-mir-208a chr14:22927625-22927735 - CCACUUCCUGUGACGGGCGAGCUUUUGGCCCGGGUUAUACCUGAUGCUCACGUAUAAGACGAGCAAAAAGCUUGUUGGUCAGAGGAGCUA ....(((((.((((.(((((((((((.((.((..((((((.((.....)).))))))..)).)).))))))))))).)))).)))))... (-41.90) ..................GAGCUUUUGGCCCGGGUUAUAC.................................................. 1 1 hsa-mir-208a_L01_M J1_ES_demeth hsa-mir-208b chr14:22957016-22957132 - CACCUCCUUCUCCUCUCAGGGAAGCUUUUUGCUCGAAUUAUGUUUCUGAUCCGAAUAUAAGACGAACAAAAGGUUUGUCUGAGGGCAGAGUGCUUCC .......((((.((((((((.((((((((((.(((..((((((((.......))))))))..))).)))))))))).)))))))).))))....... (-34.80) .........................................................UAAGACGAACAAAAGGUUUGU................... 2 1 hsa-mir-208b_R01_M J1_ES_demeth .......................................................UAUAAGACGAACAAAAGGUUU..................... 1 1 hsa-mir-208b_R02 J1_ES_demeth hsa-mir-20a chr13:90801300-90801410 + GACAGCUUCUGUAGCACUAAAGUGCUUAUAGUGCAGGUAGUGUUUAGUUAUCUACUGCAUUAUGAGCACUUAAAGUACUGCUAGCUGUAGA .((((((...((((.(((.(((((((((((((((((.(((((......)).))))))))))))))))))))..))).)))).))))))... (-41.50) .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 565 1 hsa-mir-20a_L01_M ES_Dicer .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 243 1 hsa-mir-20a_L02 J1_ES_demeth .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 223 1 hsa-mir-20a_L03 J1_ES_untr .................UAAAGUGCUUAUAGUGCAGGU..................................................... 41 1 hsa-mir-20a_L04 ES_Dicer .................UAAAGUGCUUAUAGUGCAGGUA.................................................... 21 1 hsa-mir-20a_L05 J1_ES_untr .................UAAAGUGCUUAUAGUGCAGGUA.................................................... 16 1 hsa-mir-20a_L06 ES_Dicer .................UAAAGUGCUUAUAGUGCAGGU..................................................... 15 1 hsa-mir-20a_L07 J1_ES_demeth .................UAAAGUGCUUAUAGUGCAGGUAGU.................................................. 11 1 hsa-mir-20a_L08 J1_ES_untr .................UAAAGUGCUUAUAGUGCAGGUAGU.................................................. 8 1 hsa-mir-20a_L09 J1_ES_demeth .................UAAAGUGCUUAUAGUGCAGGUAGU.................................................. 6 1 hsa-mir-20a_L10 ES_Dicer .................UAAAGUGCUUAUAGUGCAGGUA.................................................... 6 1 hsa-mir-20a_L11 J1_ES_demeth .................UAAAGUGCUUAUAGUGCAGGU..................................................... 6 1 hsa-mir-20a_L12 J1_ES_untr .................UAAAGUGCUUAUAGUGCAG....................................................... 4 1 hsa-mir-20a_L13 ES_Dicer .....................GUGCUUAUAGUGCAGGUAG................................................... 3 1 hsa-mir-20a_L14 ES_Dicer ..................AAAGUGCUUAUAGUGCAGGUAG................................................... 2 1 hsa-mir-20a_L15 ES_Dicer ................CUAAAGUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L16 ES_Dicer .....................GUGCUUAUAGUGCAGGUAGU.................................................. 1 1 hsa-mir-20a_L17 ES_Dicer .....................GUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L18 J1_ES_untr ...................AAGUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L19 J1_ES_untr .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L20 ES_Dicer-DEL hsa-mir-20b chrX:133131485-133131593 - GAUAAGAUUGGGUCCUAGUAGUACCAAAGUGCUCAUAGUGCAGGUAGUUUUGGCAUGACUCUACUGUAGUAUGGGCACUUCCAGUACUCUUGGAUAA ...........((((.((.(((((..(((((((((((.(((((..((((.......))))...))))).)))))))))))...))))))).)))).. (-37.60) ........................CAAAGUGCUCAUAGUGCAGGUAG.................................................. 735 1 hsa-mir-20b_L01_M J1_ES_untr ........................CAAAGUGCUCAUAGUGCAGGUAG.................................................. 340 1 hsa-mir-20b_L02 ES_Dicer ........................CAAAGUGCUCAUAGUGCAGGUAG.................................................. 126 1 hsa-mir-20b_L03 J1_ES_demeth ........................CAAAGUGCUCAUAGUGCAGGUAGU................................................. 54 1 hsa-mir-20b_L04 J1_ES_untr ........................CAAAGUGCUCAUAGUGCAGGUA................................................... 28 1 hsa-mir-20b_L05 J1_ES_untr ........................CAAAGUGCUCAUAGUGCAGGU.................................................... 20 1 hsa-mir-20b_L06 ES_Dicer ........................CAAAGUGCUCAUAGUGCAGGU.................................................... 8 1 hsa-mir-20b_L07 J1_ES_untr ........................CAAAGUGCUCAUAGUGCAGGUAGU................................................. 7 1 hsa-mir-20b_L08 ES_Dicer ........................CAAAGUGCUCAUAGUGCAGGUAGU................................................. 6 1 hsa-mir-20b_L09 J1_ES_demeth ........................CAAAGUGCUCAUAGUGCAGGUA................................................... 5 1 hsa-mir-20b_L10 ES_Dicer ........................CAAAGUGCUCAUAGUGCAGGUA................................................... 5 1 hsa-mir-20b_L11 J1_ES_demeth ............................GUGCUCAUAGUGCAGGUAGU................................................. 3 1 hsa-mir-20b_L12 ES_Dicer ........................CAAAGUGCUCAUAGUGCAGGU.................................................... 3 1 hsa-mir-20b_L13 J1_ES_demeth ............................GUGCUCAUAGUGCAGGUAG.................................................. 2 1 hsa-mir-20b_L14 J1_ES_untr .........................AAAGUGCUCAUAGUGCAGGUAG.................................................. 2 1 hsa-mir-20b_L15 J1_ES_untr ........................CAAAGUGCUCAUAGUGCAG...................................................... 2 1 hsa-mir-20b_L16 J1_ES_demeth .........................AAAGUGCUCAUAGUGCAGGUAG.................................................. 1 1 hsa-mir-20b_L17 ES_Dicer ........................CAAAGUGCUCAUAGUGCAGGUAGUUU............................................... 1 1 hsa-mir-20b_L18 J1_ES_untr ........................CAAAGUGCUCAUAGUGCAG...................................................... 1 1 hsa-mir-20b_L19 J1_ES_untr .........................AAAGUGCUCAUAGUGCAGGUAG.................................................. 1 1 hsa-mir-20b_L20 J1_ES_demeth hsa-mir-21 chr17:55273389-55273500 + GUACCACCUUGUCGGGUAGCUUAUCAGACUGAUGUUGACUGUUGAAUCUCAUGGCAACACCAGUCGAUGGGCUGUCUGACAUUUUGGUAUC ((((((...((((((..((((((((.(((((.(((((.((((.(.....)))))))))).)))))))))))))..))))))...)))))). (-43.40) ................UAGCUUAUCAGACUGAUGUUGAC.................................................... 3411 1 hsa-mir-21_L01_M J1_ES_untr ................UAGCUUAUCAGACUGAUGUUGAC.................................................... 2997 1 hsa-mir-21_L02 J1_ES_demeth ................UAGCUUAUCAGACUGAUGUUGA..................................................... 2521 1 hsa-mir-21_L03 J1_ES_demeth ................UAGCUUAUCAGACUGAUGUUGA..................................................... 1438 1 hsa-mir-21_L04 J1_ES_untr ................UAGCUUAUCAGACUGAUGUUGAC.................................................... 456 1 hsa-mir-21_L05 ES_Dicer ................UAGCUUAUCAGACUGAUGUUGA..................................................... 328 1 hsa-mir-21_L06 ES_Dicer ................UAGCUUAUCAGACUGAUGUUG...................................................... 262 1 hsa-mir-21_L07 J1_ES_demeth ................UAGCUUAUCAGACUGAUGUUGACU................................................... 132 1 hsa-mir-21_L08 J1_ES_demeth ................UAGCUUAUCAGACUGAUGUUGACU................................................... 94 1 hsa-mir-21_L09 J1_ES_untr ................UAGCUUAUCAGACUGAUGUUG...................................................... 55 1 hsa-mir-21_L10 J1_ES_untr ................UAGCUUAUCAGACUGAUGUUG...................................................... 47 1 hsa-mir-21_L11 ES_Dicer ...............GUAGCUUAUCAGACUGAUGUUGAC.................................................... 11 1 hsa-mir-21_L12 J1_ES_demeth ...............GUAGCUUAUCAGACUGAUGUUGAC.................................................... 11 1 hsa-mir-21_L13 J1_ES_untr ................UAGCUUAUCAGACUGAUGUUGACU................................................... 8 1 hsa-mir-21_L14 ES_Dicer ....................UUAUCAGACUGAUGUUGAC.................................................... 8 1 hsa-mir-21_L15 J1_ES_demeth ...............GUAGCUUAUCAGACUGAUGUUGAC.................................................... 4 1 hsa-mir-21_L16 ES_Dicer ...................CUUAUCAGACUGAUGUUGA..................................................... 4 1 hsa-mir-21_L17 J1_ES_demeth ...................CUUAUCAGACUGAUGUUGAC.................................................... 4 1 hsa-mir-21_L18 J1_ES_demeth ................UAGCUUAUCAGACUGAUGUUGAC.................................................... 4 1 hsa-mir-21_L19 ES_Dicer-DEL ................UAGCUUAUCAGACUGAUGUUGA..................................................... 4 1 hsa-mir-21_L20 ES_Dicer-DEL ................UAGCUUAUCAGACUGAUGUUGACU................................................... 4 1 hsa-mir-21_L21 ES_Dicer-DEL .................AGCUUAUCAGACUGAUGUUGAC.................................................... 3 1 hsa-mir-21_L22 ES_Dicer .................AGCUUAUCAGACUGAUGUUGA..................................................... 3 1 hsa-mir-21_L23 J1_ES_demeth .................AGCUUAUCAGACUGAUGUUGAC.................................................... 3 1 hsa-mir-21_L24 J1_ES_untr ................UAGCUUAUCAGACUGAUGUUG...................................................... 3 1 hsa-mir-21_L25 ES_Dicer-DEL ...............GUAGCUUAUCAGACUGAUGUUGA..................................................... 2 1 hsa-mir-21_L26 ES_Dicer ................UAGCUUAUCAGACUGAUGUU....................................................... 2 1 hsa-mir-21_L27 J1_ES_demeth ..................GCUUAUCAGACUGAUGUUGAC.................................................... 2 1 hsa-mir-21_L28 J1_ES_demeth ....................UUAUCAGACUGAUGUUGA..................................................... 2 1 hsa-mir-21_L29 J1_ES_demeth ...................CUUAUCAGACUGAUGUUGA..................................................... 1 1 hsa-mir-21_L30 ES_Dicer ................UAGCUUAUCAGACUGAUGUU....................................................... 1 1 hsa-mir-21_L31 ES_Dicer ..................GCUUAUCAGACUGAUGUUGAC.................................................... 1 1 hsa-mir-21_L32 ES_Dicer ....................UUAUCAGACUGAUGUUGAC.................................................... 1 1 hsa-mir-21_L33 ES_Dicer ...................CUUAUCAGACUGAUGUUGAC.................................................... 1 1 hsa-mir-21_L34 ES_Dicer ...............GUAGCUUAUCAGACUGAUGUUG...................................................... 1 1 hsa-mir-21_L35 ES_Dicer ..............GGUAGCUUAUCAGACUGAUGUUGAC.................................................... 1 1 hsa-mir-21_L36 J1_ES_demeth ...............GUAGCUUAUCAGACUGAUGUUGA..................................................... 1 1 hsa-mir-21_L37 J1_ES_demeth ................UAGCUUAUCAGACUGAUGU........................................................ 1 1 hsa-mir-21_L38 J1_ES_demeth ...............GUAGCUUAUCAGACUGAUGUUGA..................................................... 1 1 hsa-mir-21_L39 J1_ES_untr .................AGCUUAUCAGACUGAUGUUGA..................................................... 1 1 hsa-mir-21_L40 J1_ES_untr ..................GCUUAUCAGACUGAUGUUGAC.................................................... 1 1 hsa-mir-21_L41 J1_ES_untr ....................UUAUCAGACUGAUGUUGAC.................................................... 1 1 hsa-mir-21_L42 J1_ES_untr hsa-mir-210 chr11:558069-558218 - UCCCUCCGCCCGCCCACCCGGCAGUGCCUCCAGGCGCAGGGCAGCCCCUGCCCACCGCACACUGCGCUGCCCCAGACCCACUGUGCGUGUGACAGCGGCUGAUCUGUGCCUGGGCAGCGCGACCCUCCUGGCCCC .......(((.(((.....))).((((.(((((((((((..(((((.(((..(((((((((.((.((((...))).).)).)))))).))).))).)))))..)))))))))))..)))).........)))... (-65.30) ................................................................................CUGUGCGUGUGACAGCGGCUGA................................. 256 1 hsa-mir-210_R01_M J1_ES_untr ................................................................................CUGUGCGUGUGACAGCGGCUGA................................. 57 1 hsa-mir-210_R02 ES_Dicer ................................................................................CUGUGCGUGUGACAGCGGCUGA................................. 35 1 hsa-mir-210_R03 J1_ES_demeth ................................................................................CUGUGCGUGUGACAGCGGCUG.................................. 7 1 hsa-mir-210_R04 J1_ES_demeth ................................................................................CUGUGCGUGUGACAGCGGCUGAU................................ 6 1 hsa-mir-210_R05 J1_ES_untr ................................................................................CUGUGCGUGUGACAGCGGCUG.................................. 5 1 hsa-mir-210_R06 J1_ES_untr ...............................................................................ACUGUGCGUGUGACAGCGGCUGA................................. 4 1 hsa-mir-210_R07 J1_ES_untr ................................................................................CUGUGCGUGUGACAGCGGCUG.................................. 2 1 hsa-mir-210_R08 ES_Dicer ................................................................................CUGUGCGUGUGACAGCGGCUGAU................................ 2 1 hsa-mir-210_R09 ES_Dicer ...............................................................................ACUGUGCGUGUGACAGCGGCUGA................................. 1 1 hsa-mir-210_R10 ES_Dicer ...............................................................................ACUGUGCGUGUGACAGCGGCUG.................................. 1 1 hsa-mir-210_R11 ES_Dicer ...............................................................................ACUGUGCGUGUGACAGCGGCUG.................................. 1 1 hsa-mir-210_R12 J1_ES_untr ...............................................................................ACUGUGCGUGUGACAGCGGCUG.................................. 1 1 hsa-mir-210_R13 J1_ES_demeth ................................................................................CUGUGCGUGUGACAGCGGCUGAU................................ 1 1 hsa-mir-210_R14 J1_ES_demeth hsa-mir-214 chr1:170374541-170374690 - AGGAACCAAGGGCCUGGCUGGACAGAGUUGUCAUGUGUCUGCCUGUCUACACUUGCUGUGCAGAACAUCCGCUCACCUGUACAGCAGGCACAGACAGGCAGUCACAUGACAACCCAGCCUGAAUGACAA (((..(...)..)))((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).......... (-68.72) ................................................................................ACAGCAGGCACAGACAGGCAGU........................... 3 1 hsa-mir-214_R01_M J1_ES_demeth ...............................................................................UACAGCAGGCACAGACAGGCAGU........................... 2 1 hsa-mir-214_R02 J1_ES_demeth hsa-mir-218-1 chr4:20138976-20139125 + GUUGGUGUAGUGAUAAUGUAGCGAGAUUUUCUGUUGUGCUUGAUCUAACCAUGUGGUUGCGAGGUAUGAGUAAAACAUGGUUCCGUCAAGCACCAUGGAACGUCACGCAGCUUUCUACAGCAUGACAAG ..((.(((((.......((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))...))))).))....... (-48.60) .................................UUGUGCUUGAUCUAACCAUGUG.......................................................................... 8 2 hsa-mir-218-1_L01_M J1_ES_demeth .................................UUGUGCUUGAUCUAACCAUGU........................................................................... 7 2 hsa-mir-218-1_L02 J1_ES_untr .................................UUGUGCUUGAUCUAACCAUGU........................................................................... 7 2 hsa-mir-218-1_L03 J1_ES_demeth .................................UUGUGCUUGAUCUAACCAUGUG.......................................................................... 5 2 hsa-mir-218-1_L04 J1_ES_untr .................................UUGUGCUUGAUCUAACCAUGUGG......................................................................... 5 2 hsa-mir-218-1_L05 J1_ES_untr .................................UUGUGCUUGAUCUAACCAUGUG.......................................................................... 2 2 hsa-mir-218-1_L06 ES_Dicer .................................UUGUGCUUGAUCUAACCAUGU........................................................................... 2 2 hsa-mir-218-1_L07 ES_Dicer .................................UUGUGCUUGAUCUAACCAUGUGG......................................................................... 1 2 hsa-mir-218-1_L08 J1_ES_demeth ........................................................................AAACAUGGUUCCGUCAAGCAC.................................... 1 1 hsa-mir-218-1_R01*_M J1_ES_untr hsa-mir-218-2 chr5:168127709-168127858 - CCUUGACUCUGACCAGUCGCUGCGGGGCUUUCCUUUGUGCUUGAUCUAACCAUGUGGUGGAACGAUGGAAACGGAACAUGGUUCUGUCAAGCACCGCGGAAAGCACCGUGCUCUCCUGCAGCAUGGCCC ............(((...(((((((((((((((...(((((((((..((((((((..........((....))..))))))))..)))))))))...)))))))..........)))))))).)))... (-52.50) ..................................UUGUGCUUGAUCUAACCAUGUG......................................................................... 8 2 hsa-mir-218-2_L01_M J1_ES_demeth ..................................UUGUGCUUGAUCUAACCAUGU.......................................................................... 7 2 hsa-mir-218-2_L02 J1_ES_untr ..................................UUGUGCUUGAUCUAACCAUGU.......................................................................... 7 2 hsa-mir-218-2_L03 J1_ES_demeth ..................................UUGUGCUUGAUCUAACCAUGUG......................................................................... 5 2 hsa-mir-218-2_L04 J1_ES_untr ..................................UUGUGCUUGAUCUAACCAUGUGG........................................................................ 5 2 hsa-mir-218-2_L05 J1_ES_untr ..................................UUGUGCUUGAUCUAACCAUGUG......................................................................... 2 2 hsa-mir-218-2_L06 ES_Dicer ..................................UUGUGCUUGAUCUAACCAUGU.......................................................................... 2 2 hsa-mir-218-2_L07 ES_Dicer .................................UUUGUGCUUGAUCUAACCAUGU.......................................................................... 2 1 hsa-mir-218-2_L08 J1_ES_untr ..................................UUGUGCUUGAUCUAACCAUGUGG........................................................................ 1 2 hsa-mir-218-2_L09 J1_ES_demeth .................................UUUGUGCUUGAUCUAACCAUGU.......................................................................... 1 1 hsa-mir-218-2_L10 J1_ES_demeth .............................................................................AUGGUUCUGUCAAGCACCGCG............................... 1 1 hsa-mir-218-2_R01*_M J1_ES_demeth hsa-mir-219-1 chr6:33283570-33283719 + CUCCCUUCCCCGCCCCGGGCCGCGGCUCCUGAUUGUCCAAACGCAAUUCUCGAGUCUAUGGCUCCGGCCGAGAGUUGAGUCUGGACGUCCCGAGCCGCCGCCCCCAAACCUCGAGCGGGAGAGCGGGUC ..(((((((((((.(.((((.(((((((..(((.(((((.((.(((((((((.(((.........)))))))))))).)).))))))))..))))))).)))).........).))))).))).))).. (-64.60) .............................UGAUUGUCCAAACGCAAUUCUCG............................................................................. 106 1 hsa-mir-219-1_L01_M J1_ES_demeth .............................UGAUUGUCCAAACGCAAUUCUCG............................................................................. 68 1 hsa-mir-219-1_L02 J1_ES_untr .............................UGAUUGUCCAAACGCAAUUCUCG............................................................................. 7 1 hsa-mir-219-1_L03 ES_Dicer .............................UGAUUGUCCAAACGCAAUUCUC.............................................................................. 5 1 hsa-mir-219-1_L04 J1_ES_untr .............................UGAUUGUCCAAACGCAAUUCUC.............................................................................. 5 1 hsa-mir-219-1_L05 J1_ES_demeth .............................UGAUUGUCCAAACGCAAUUCU............................................................................... 5 2 hsa-mir-219-1_L06 J1_ES_demeth .............................UGAUUGUCCAAACGCAAUUCUCGA............................................................................ 5 1 hsa-mir-219-1_L07 J1_ES_demeth .............................UGAUUGUCCAAACGCAAUUCUCGA............................................................................ 3 1 hsa-mir-219-1_L08 J1_ES_untr .............................UGAUUGUCCAAACGCAAUUCUC.............................................................................. 1 1 hsa-mir-219-1_L09 ES_Dicer ...............................AUUGUCCAAACGCAAUUCUC.............................................................................. 1 1 hsa-mir-219-1_L10 J1_ES_demeth ..............................GAUUGUCCAAACGCAAUUCUCG............................................................................. 1 1 hsa-mir-219-1_L11 J1_ES_demeth hsa-mir-219-2 chr9:130194698-130194834 - GACCAGGGCCCUGAACUCAGGGGCUUCGCCACUGAUUGUCCAAACGCAAUUCUUGUACGAGUCUGCGGCCAACCGAGAAUUGUGGCUGGACAUCUGUGGCUGAGCUCCGGGCGCAACAGGGGCG ......(.(((((..(((.(((((((.(((((.(((.(((((..(((((((((((...(.((.....)))...)))))))))))..)))))))).))))).)))))))))).....))))).). (-60.30) ................................UGAUUGUCCAAACGCAAUUCU....................................................................... 5 2 hsa-mir-219-2_L01_M J1_ES_demeth ................................UGAUUGUCCAAACGCAAUUCUU...................................................................... 2 1 hsa-mir-219-2_L02 J1_ES_demeth ................................UGAUUGUCCAAACGCAAUUCUUG..................................................................... 2 1 hsa-mir-219-2_L03 J1_ES_demeth ................................UGAUUGUCCAAACGCAAUUCUUGU.................................................................... 1 1 hsa-mir-219-2_L04 J1_ES_demeth ................................UGAUUGUCCAAACGCAAUUCUUG..................................................................... 1 1 hsa-mir-219-2_L05 J1_ES_untr ................................UGAUUGUCCAAACGCAAUUCUU...................................................................... 1 1 hsa-mir-219-2_L06 J1_ES_untr ...........................................................................AGAAUUGUGGCUGGACAUCUGU........................... 3 1 hsa-mir-219-2_R01*_M J1_ES_untr hsa-mir-22 chr17:1563927-1564051 - GCCCUCACCUGGCUGAGCCGCAGUAGUUCUUCAGUGGCAAGCUUUAUGUCCUGACCCAGCUAAAGCUGCCAGUUGAAGAACUGUUGCCCUCUGCCCCUGGCUUC (((.......(((.(((..((((((((((((((((((((.((((((.((.........))))))))))))).))))))))))))))).))).)))...)))... (-43.20) ........................AGUUCUUCAGUGGCAAGCUUUA.......................................................... 39 1 hsa-mir-22_L01*_M J1_ES_demeth ........................AGUUCUUCAGUGGCAAGCUUU........................................................... 20 1 hsa-mir-22_L02* J1_ES_demeth ........................AGUUCUUCAGUGGCAAGCUUUA.......................................................... 8 1 hsa-mir-22_L03* J1_ES_untr ........................AGUUCUUCAGUGGCAAGCUUUAU......................................................... 2 1 hsa-mir-22_L04* J1_ES_demeth ........................AGUUCUUCAGUGGCAAGCUU............................................................ 1 1 hsa-mir-22_L05* ES_Dicer ........................AGUUCUUCAGUGGCAAGCUUU........................................................... 1 1 hsa-mir-22_L06* J1_ES_untr .........................GUUCUUCAGUGGCAAGCUUUA.......................................................... 1 1 hsa-mir-22_L07* J1_ES_demeth ..............................................................AAGCUGCCAGUUGAAGAACUGU.................... 401 1 hsa-mir-22_R01_M J1_ES_demeth ..............................................................AAGCUGCCAGUUGAAGAACUGU.................... 70 1 hsa-mir-22_R02 J1_ES_untr ..............................................................AAGCUGCCAGUUGAAGAACUGU.................... 44 1 hsa-mir-22_R03 ES_Dicer ..............................................................AAGCUGCCAGUUGAAGAACU...................... 17 1 hsa-mir-22_R04 ES_Dicer ..............................................................AAGCUGCCAGUUGAAGAACUGUU................... 12 1 hsa-mir-22_R05 J1_ES_demeth ..............................................................AAGCUGCCAGUUGAAGAACUG..................... 4 1 hsa-mir-22_R06 J1_ES_demeth ...............................................................AGCUGCCAGUUGAAGAACUGU.................... 4 1 hsa-mir-22_R07 J1_ES_demeth ..............................................................AAGCUGCCAGUUGAAGAACU...................... 3 1 hsa-mir-22_R08 J1_ES_demeth ...............................................................AGCUGCCAGUUGAAGAACUGU.................... 2 1 hsa-mir-22_R09 ES_Dicer ..............................................................AAGCUGCCAGUUGAAGAACUG..................... 1 1 hsa-mir-22_R10 ES_Dicer .................................................................CUGCCAGUUGAAGAACUGU.................... 1 1 hsa-mir-22_R11 ES_Dicer ..............................................................AAGCUGCCAGUUGAAGAACUGUU................... 1 1 hsa-mir-22_R12 J1_ES_untr .................................................................CUGCCAGUUGAAGAACUGU.................... 1 1 hsa-mir-22_R13 J1_ES_demeth hsa-mir-221 chrX:45490509-45490658 - ACUUGCAAGCUGAACAUCCAGGUCUGGGGCAUGAACCUGGCAUACAAUGUAGAUUUCUGUGUUCGUUAGGCAACAGCUACAUUGUCUGCUGGGUUUCAGGCUACCUGGAAACAUGUUCUCCAUUGGCUG .......((((((((((((((((....(((.((((((..(((.(((((((((....(((((((.....))).))))))))))))).)))..)).)))).))))))))))....)))))......)))). (-49.20) ..................................ACCUGGCAUACAAUGUAGAUUUCUGU..................................................................... 1 1 hsa-mir-221_L01*_M J1_ES_untr ..................................ACCUGGCAUACAAUGUAGAUUUCU....................................................................... 1 1 hsa-mir-221_L02* J1_ES_demeth ..........................................................................AGCUACAUUGUCUGCUGGGUUUC................................ 261 1 hsa-mir-221_R01_M J1_ES_demeth ..........................................................................AGCUACAUUGUCUGCUGGGUUUC................................ 195 1 hsa-mir-221_R02 J1_ES_untr ..........................................................................AGCUACAUUGUCUGCUGGGUUU................................. 104 1 hsa-mir-221_R03 J1_ES_demeth ..........................................................................AGCUACAUUGUCUGCUGGGUUU................................. 77 1 hsa-mir-221_R04 J1_ES_untr ..........................................................................AGCUACAUUGUCUGCUGGGUUUCA............................... 39 1 hsa-mir-221_R05 J1_ES_untr ..........................................................................AGCUACAUUGUCUGCUGGGUUUCA............................... 25 1 hsa-mir-221_R06 J1_ES_demeth ..........................................................................AGCUACAUUGUCUGCUGGGUUUCA............................... 3 1 hsa-mir-221_R07 ES_Dicer ..........................................................................AGCUACAUUGUCUGCUGGGUU.................................. 3 1 hsa-mir-221_R08 J1_ES_demeth ..........................................................................AGCUACAUUGUCUGCUGGGUUUCAG.............................. 2 1 hsa-mir-221_R09 J1_ES_untr ..........................................................................AGCUACAUUGUCUGCUGGGUUU................................. 1 1 hsa-mir-221_R10 ES_Dicer .........................................................................CAGCUACAUUGUCUGCUGGG.................................... 1 1 hsa-mir-221_R11 ES_Dicer ..........................................................................AGCUACAUUGUCUGCUGGGUU.................................. 1 1 hsa-mir-221_R12 J1_ES_untr hsa-mir-222 chrX:45491345-45491494 - GGAUCACCCAGCUGCUGGAAGGUGUAGGUACCCUCAAUGGCUCAGUAGCCAGUGUAGAUCCUGUCUUUCGUAAUCAGCAGCUACAUCUGGCUACUGGGUCUCUGAUGGCAUCUUCUAGCUUCUGCUUCA ........(((..(((((((((((......((.(((..(((((((((((((((((((...(((...........)))...))))).))))))))))))))..))).)))))))))))))..)))..... (-57.50) .........................................UCAGUAGCCAGUGUAGAUCCUGU................................................................. 1 1 hsa-mir-222_L01*_M J1_ES_untr ........................................CUCAGUAGCCAGUGUAGAUCC.................................................................... 1 1 hsa-mir-222_L02* J1_ES_demeth ..............................................................................AGCUACAUCUGGCUACUGGGU.............................. 21 1 hsa-mir-222_R01_M J1_ES_untr ..............................................................................AGCUACAUCUGGCUACUGGGU.............................. 16 1 hsa-mir-222_R02 J1_ES_demeth ..............................................................................AGCUACAUCUGGCUACUGGGUCU............................ 16 1 hsa-mir-222_R03 J1_ES_demeth ..............................................................................AGCUACAUCUGGCUACUGGGUCU............................ 13 1 hsa-mir-222_R04 J1_ES_untr ..............................................................................AGCUACAUCUGGCUACUGGGUCUC........................... 11 1 hsa-mir-222_R05 J1_ES_untr ..............................................................................AGCUACAUCUGGCUACUGGGUC............................. 8 1 hsa-mir-222_R06 J1_ES_untr ..............................................................................AGCUACAUCUGGCUACUGGGUCU............................ 5 1 hsa-mir-222_R07 ES_Dicer ..............................................................................AGCUACAUCUGGCUACUGGGUC............................. 5 1 hsa-mir-222_R08 J1_ES_demeth ..............................................................................AGCUACAUCUGGCUACUGGGUCUCU.......................... 4 1 hsa-mir-222_R09 J1_ES_demeth .............................................................................CAGCUACAUCUGGCUACUGGGU.............................. 3 1 hsa-mir-222_R10 J1_ES_demeth ..............................................................................AGCUACAUCUGGCUACUGGGUCUC........................... 3 1 hsa-mir-222_R11 J1_ES_demeth ..............................................................................AGCUACAUCUGGCUACUGGGUCUC........................... 2 1 hsa-mir-222_R12 ES_Dicer ..............................................................................AGCUACAUCUGGCUACUGGGUCUCU.......................... 2 1 hsa-mir-222_R13 J1_ES_untr ................................................................................CUACAUCUGGCUACUGGGU.............................. 1 1 hsa-mir-222_R14 ES_Dicer ..............................................................................AGCUACAUCUGGCUACUGGG............................... 1 1 hsa-mir-222_R15 ES_Dicer ..............................................................................AGCUACAUCUGGCUACUGGGU.............................. 1 1 hsa-mir-222_R16 ES_Dicer ..............................................................................AGCUACAUCUGGCUACUGGG............................... 1 1 hsa-mir-222_R17 J1_ES_untr ............................................................................GCAGCUACAUCUGGCUACUGGGUC............................. 1 1 hsa-mir-222_R18 J1_ES_demeth hsa-mir-223 chrX:65155417-65155566 + AGCUCUUGGCCUGGCCUCCUGCAGUGCCACGCUCCGUGUAUUUGACAAGCUGAGUUGGACACUCCAUGUGGUAGAGUGUCAGUUUGUCAAAUACCCCAAGUGCGGCACAUGCUUACCAGCUCUAGGCCA ......((((((((.((...((((((((.((((..(.((((((((((((((......(((((((.........))))))))))))))))))))).)..)))).))))).))).....))..)))))))) (-56.90) ............................................................................UGUCAGUUUGUCAAAUACCCCAA.............................. 1 1 hsa-mir-223_R01_M J1_ES_demeth hsa-mir-23a chr19:13808381-13808493 - CCUGUGCCACGGCCGGCUGGGGUUCCUGGGGAUGGGAUUUGCUUCCUGUCACAAAUCACAUUGCCAGGGAUUUCCAACCGACCCUGAGCUCUGCC ...(.((((.((.(((.((((((((((((.((((.((((((..........)))))).)))).))))))).))))).))).)).)).)).).... (-38.60) ..................GGGGUUCCUGGGGAUGGGAUUU....................................................... 1 1 hsa-mir-23a_L01*_M J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCA................... 972 1 hsa-mir-23a_R01_M J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCA................... 605 1 hsa-mir-23a_R02 J1_ES_untr ......................................................AUCACAUUGCCAGGGAUUUCC.................... 428 1 hsa-mir-23a_R03 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCAA.................. 420 1 hsa-mir-23a_R04 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCAA.................. 368 1 hsa-mir-23a_R05 J1_ES_untr ......................................................AUCACAUUGCCAGGGAUUUCC.................... 122 1 hsa-mir-23a_R06 J1_ES_untr ......................................................AUCACAUUGCCAGGGAUUUC..................... 89 1 hsa-mir-23a_R07 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCA................... 55 1 hsa-mir-23a_R08 ES_Dicer ......................................................AUCACAUUGCCAGGGAUUUCCAA.................. 24 1 hsa-mir-23a_R09 ES_Dicer ......................................................AUCACAUUGCCAGGGAUUUCC.................... 21 1 hsa-mir-23a_R10 ES_Dicer ......................................................AUCACAUUGCCAGGGAUUU...................... 17 1 hsa-mir-23a_R11 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUC..................... 10 1 hsa-mir-23a_R12 J1_ES_untr .....................................................AAUCACAUUGCCAGGGAUUUCCA................... 9 1 hsa-mir-23a_R13 J1_ES_demeth .......................................................UCACAUUGCCAGGGAUUUCCA................... 9 1 hsa-mir-23a_R14 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUC..................... 8 1 hsa-mir-23a_R15 ES_Dicer .....................................................AAUCACAUUGCCAGGGAUUUCC.................... 6 1 hsa-mir-23a_R16 J1_ES_demeth .....................................................AAUCACAUUGCCAGGGAUUUCCA................... 5 1 hsa-mir-23a_R17 J1_ES_untr .....................................................AAUCACAUUGCCAGGGAUUUCC.................... 4 1 hsa-mir-23a_R18 J1_ES_untr .......................................................UCACAUUGCCAGGGAUUUCCA................... 4 1 hsa-mir-23a_R19 J1_ES_untr .....................................................AAUCACAUUGCCAGGGAUUUCC.................... 3 1 hsa-mir-23a_R20 ES_Dicer .....................................................AAUCACAUUGCCAGGGAUUUC..................... 3 1 hsa-mir-23a_R21 J1_ES_demeth ..........................................................CAUUGCCAGGGAUUUCCA................... 3 1 hsa-mir-23a_R22 J1_ES_demeth .....................................................AAUCACAUUGCCAGGGAUUUCCAA.................. 3 1 hsa-mir-23a_R23 J1_ES_demeth ..........................................................CAUUGCCAGGGAUUUCCAA.................. 3 1 hsa-mir-23a_R24 J1_ES_demeth .......................................................UCACAUUGCCAGGGAUUUCCAA.................. 3 1 hsa-mir-23a_R25 J1_ES_untr .......................................................UCACAUUGCCAGGGAUUUCCA................... 2 1 hsa-mir-23a_R26 ES_Dicer ......................................................AUCACAUUGCCAGGGAUU....................... 2 2 hsa-mir-23a_R27 J1_ES_demeth .....................................................AAUCACAUUGCCAGGGAUUU...................... 2 1 hsa-mir-23a_R28 J1_ES_demeth .......................................................UCACAUUGCCAGGGAUUUCCAA.................. 2 1 hsa-mir-23a_R29 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCAAC................. 2 1 hsa-mir-23a_R30 J1_ES_untr .....................................................AAUCACAUUGCCAGGGAUUUCCAA.................. 2 1 hsa-mir-23a_R31 J1_ES_untr .....................................................AAUCACAUUGCCAGGGAUUUCCAA.................. 1 1 hsa-mir-23a_R32 ES_Dicer .......................................................UCACAUUGCCAGGGAUUUCCAA.................. 1 1 hsa-mir-23a_R33 ES_Dicer ......................................................AUCACAUUGCCAGGGAUUUCCAACC................ 1 1 hsa-mir-23a_R34 J1_ES_demeth .......................................................UCACAUUGCCAGGGAUUUC..................... 1 1 hsa-mir-23a_R35 J1_ES_demeth .......................................................UCACAUUGCCAGGGAUUUCC.................... 1 1 hsa-mir-23a_R36 J1_ES_demeth ......................................................AUCACAUUGCCAGGGAUUUCCAAC................. 1 1 hsa-mir-23a_R37 J1_ES_demeth ..........................................................CAUUGCCAGGGAUUUCCAA.................. 1 1 hsa-mir-23a_R38 J1_ES_untr ......................................................AUCACAUUGCCAGGGAUUU...................... 1 1 hsa-mir-23a_R39 ES_Dicer-DEL hsa-mir-23b chr9:96887291-96887427 + GGUGGCGCUGCUCUCAGGUGCUCUGGCUGCUUGGGUUCCUGGCAUGCUGAUUUGUGACUUAAGAUUAAAAUCACAUUGCCAGGGAUUACCACGCAACCACGACCUUGGCUGCUCCUCCAGAA ((.((.((.(((...((((.(..(((.(((.(((((((((((((((.((((((..............)))))))).))))))))))..))).))).))).))))).))).)).)).)).... (-47.54) ................................GGGUUCCUGGCAUGCUGAUUU..................................................................... 1 1 hsa-mir-23b_L01*_M ES_Dicer ................................GGGUUCCUGGCAUGCUGAUUU..................................................................... 1 1 hsa-mir-23b_L02* J1_ES_untr ................................GGGUUCCUGGCAUGCUGAUU...................................................................... 1 1 hsa-mir-23b_L03* J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACCAC.............................. 295 1 hsa-mir-23b_R01_M J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACCA............................... 235 1 hsa-mir-23b_R02 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACCAC.............................. 221 1 hsa-mir-23b_R03 J1_ES_untr .....................................................................AUCACAUUGCCAGGGAUUACC................................ 120 1 hsa-mir-23b_R04 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACCA............................... 93 1 hsa-mir-23b_R05 J1_ES_untr .....................................................................AUCACAUUGCCAGGGAUUAC................................. 33 1 hsa-mir-23b_R06 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACC................................ 27 1 hsa-mir-23b_R07 J1_ES_untr .....................................................................AUCACAUUGCCAGGGAUUACCAC.............................. 17 1 hsa-mir-23b_R08 ES_Dicer .....................................................................AUCACAUUGCCAGGGAUUACCA............................... 11 1 hsa-mir-23b_R09 ES_Dicer ......................................................................UCACAUUGCCAGGGAUUACCAC.............................. 10 1 hsa-mir-23b_R10 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACC................................ 8 1 hsa-mir-23b_R11 ES_Dicer .....................................................................AUCACAUUGCCAGGGAUUAC................................. 8 1 hsa-mir-23b_R12 J1_ES_untr ......................................................................UCACAUUGCCAGGGAUUACCAC.............................. 5 1 hsa-mir-23b_R13 J1_ES_untr ......................................................................UCACAUUGCCAGGGAUUACCA............................... 5 1 hsa-mir-23b_R14 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUA.................................. 4 1 hsa-mir-23b_R15 J1_ES_demeth ....................................................................AAUCACAUUGCCAGGGAUUACC................................ 4 1 hsa-mir-23b_R16 J1_ES_demeth ......................................................................UCACAUUGCCAGGGAUUACCAC.............................. 3 1 hsa-mir-23b_R17 ES_Dicer .........................................................................CAUUGCCAGGGAUUACCAC.............................. 3 1 hsa-mir-23b_R18 J1_ES_demeth ......................................................................UCACAUUGCCAGGGAUUAC................................. 2 1 hsa-mir-23b_R19 ES_Dicer ....................................................................AAUCACAUUGCCAGGGAUUACCAC.............................. 2 1 hsa-mir-23b_R20 J1_ES_untr .........................................................................CAUUGCCAGGGAUUACCA............................... 2 1 hsa-mir-23b_R21 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUU................................... 2 2 hsa-mir-23b_R22 J1_ES_demeth .....................................................................AUCACAUUGCCAGGGAUUACCACG............................. 1 1 hsa-mir-23b_R23 ES_Dicer ....................................................................AAUCACAUUGCCAGGGAUUACC................................ 1 1 hsa-mir-23b_R24 ES_Dicer ..........................................................................AUUGCCAGGGAUUACCAC.............................. 1 1 hsa-mir-23b_R25 ES_Dicer ......................................................................UCACAUUGCCAGGGAUUAC................................. 1 1 hsa-mir-23b_R26 J1_ES_demeth ......................................................................UCACAUUGCCAGGGAUUACC................................ 1 1 hsa-mir-23b_R27 J1_ES_demeth ....................................................................AAUCACAUUGCCAGGGAUUACCAC.............................. 1 1 hsa-mir-23b_R28 J1_ES_demeth hsa-mir-24-1 chr9:96888104-96888211 + GGACCCGCCCUCCGGUGCCUACUGAGCUGAUAUCAGUUCUCAUUUUACACACUGGCUCAGUUCAGCAGGAACAGGAGUCGAGCCCUU ((.(.((..((((.((.(((.(((((((((..(((((.............))))).))))))))).))).)).)))).)).).)).. (-30.32) ....................................................UGGCUCAGUUCAGCAGGAACAG............. 1263 2 hsa-mir-24-1_R01_M J1_ES_demeth ....................................................UGGCUCAGUUCAGCAGGAACAG............. 433 2 hsa-mir-24-1_R02 J1_ES_untr ....................................................UGGCUCAGUUCAGCAGGAACA.............. 103 2 hsa-mir-24-1_R03 J1_ES_demeth ....................................................UGGCUCAGUUCAGCAGGAAC............... 71 2 hsa-mir-24-1_R04 J1_ES_demeth ....................................................UGGCUCAGUUCAGCAGGAACA.............. 37 2 hsa-mir-24-1_R05 J1_ES_untr .......................................................CUCAGUUCAGCAGGAACAG............. 26 2 hsa-mir-24-1_R06 J1_ES_demeth ....................................................UGGCUCAGUUCAGCAGGAACAG............. 18 2 hsa-mir-24-1_R07 ES_Dicer ....................................................UGGCUCAGUUCAGCAGGAACA.............. 7 2 hsa-mir-24-1_R08 ES_Dicer ....................................................UGGCUCAGUUCAGCAGGAAC............... 6 2 hsa-mir-24-1_R09 J1_ES_untr ....................................................UGGCUCAGUUCAGCAGGAA................ 5 2 hsa-mir-24-1_R10 J1_ES_demeth ....................................................UGGCUCAGUUCAGCAGGAAC............... 3 2 hsa-mir-24-1_R11 ES_Dicer ....................................................UGGCUCAGUUCAGCAGGAA................ 3 2 hsa-mir-24-1_R12 J1_ES_untr ...................................................CUGGCUCAGUUCAGCAGGAACAG............. 3 2 hsa-mir-24-1_R13 J1_ES_demeth ...................................................CUGGCUCAGUUCAGCAGGAACA.............. 1 2 hsa-mir-24-1_R14 J1_ES_untr .......................................................CUCAGUUCAGCAGGAACAG............. 1 2 hsa-mir-24-1_R15 J1_ES_untr ....................................................UGGCUCAGUUCAGCAGGAACAGGA........... 1 1 hsa-mir-24-1_R16 J1_ES_demeth hsa-mir-24-2 chr19:13808081-13808193 - CCUCCCUGGGCUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGGGUCAAGCCCC .......(((((..(((.((.((.(((.(((((((((....((((.(.........)))))..))))))))).))).)).)))))..))))). (-38.90) ...........................................................UGGCUCAGUUCAGCAGGAACAG............ 1263 2 hsa-mir-24-2_R01_M J1_ES_demeth ...........................................................UGGCUCAGUUCAGCAGGAACAG............ 433 2 hsa-mir-24-2_R02 J1_ES_untr ...........................................................UGGCUCAGUUCAGCAGGAACA............. 103 2 hsa-mir-24-2_R03 J1_ES_demeth ...........................................................UGGCUCAGUUCAGCAGGAAC.............. 71 2 hsa-mir-24-2_R04 J1_ES_demeth ...........................................................UGGCUCAGUUCAGCAGGAACA............. 37 2 hsa-mir-24-2_R05 J1_ES_untr ..............................................................CUCAGUUCAGCAGGAACAG............ 26 2 hsa-mir-24-2_R06 J1_ES_demeth ...........................................................UGGCUCAGUUCAGCAGGAACAG............ 18 2 hsa-mir-24-2_R07 ES_Dicer ...........................................................UGGCUCAGUUCAGCAGGAACA............. 7 2 hsa-mir-24-2_R08 ES_Dicer ...........................................................UGGCUCAGUUCAGCAGGAAC.............. 6 2 hsa-mir-24-2_R09 J1_ES_untr ...........................................................UGGCUCAGUUCAGCAGGAA............... 5 2 hsa-mir-24-2_R10 J1_ES_demeth ...........................................................UGGCUCAGUUCAGCAGGAAC.............. 3 2 hsa-mir-24-2_R11 ES_Dicer ...........................................................UGGCUCAGUUCAGCAGGAA............... 3 2 hsa-mir-24-2_R12 J1_ES_untr ..........................................................CUGGCUCAGUUCAGCAGGAACAG............ 3 2 hsa-mir-24-2_R13 J1_ES_demeth ..........................................................CUGGCUCAGUUCAGCAGGAACA............. 1 2 hsa-mir-24-2_R14 J1_ES_untr ..............................................................CUCAGUUCAGCAGGAACAG............ 1 2 hsa-mir-24-2_R15 J1_ES_untr hsa-mir-25 chr7:99529099-99529222 - CUCCGGGACUGGCCAGUGUUGAGAGGCGGAGACUUGGGCAAUUGCUGGACGCUGCCCUGGGCAUUGCACUUGUCUCGGUCUGACAGUGCCGGCCCAACACUGC ....(((.(((((.(.((((...((((.(((((..(.(((((.(((((.......))..)))))))).)..))))).)))))))).)))))))))........ (-42.00) .......................AGGCGGAGACUUGGGCAAUUGCU......................................................... 2 1 hsa-mir-25_L01*_M J1_ES_untr .......................AGGCGGAGACUUGGGCAAUUG........................................................... 1 1 hsa-mir-25_L02* ES_Dicer .......................AGGCGGAGACUUGGGCAAUUGC.......................................................... 1 1 hsa-mir-25_L03* J1_ES_demeth .......................AGGCGGAGACUUGGGCAAUUGC.......................................................... 1 1 hsa-mir-25_L04* J1_ES_untr ..CCGGGACUGGCCAGUGUUGA................................................................................. 1 1 hsa-mir-25_L05* ES_Dicer-DEL .............................................................CAUUGCACUUGUCUCGGUCUGA.................... 837 1 hsa-mir-25_R01_M J1_ES_untr .............................................................CAUUGCACUUGUCUCGGUCUGA.................... 540 1 hsa-mir-25_R02 J1_ES_demeth .............................................................CAUUGCACUUGUCUCGGUCUGA.................... 149 1 hsa-mir-25_R03 ES_Dicer .............................................................CAUUGCACUUGUCUCGGUCUG..................... 19 1 hsa-mir-25_R04 J1_ES_untr .............................................................CAUUGCACUUGUCUCGGUCUG..................... 16 1 hsa-mir-25_R05 J1_ES_demeth .............................................................CAUUGCACUUGUCUCGGUCUG..................... 13 1 hsa-mir-25_R06 ES_Dicer .............................................................CAUUGCACUUGUCUCGGUCU...................... 11 1 hsa-mir-25_R07 ES_Dicer ..............................................................AUUGCACUUGUCUCGGUCUGA.................... 4 1 hsa-mir-25_R08 J1_ES_untr ..............................................................AUUGCACUUGUCUCGGUCUGA.................... 3 1 hsa-mir-25_R09 J1_ES_demeth ..............................................................AUUGCACUUGUCUCGGUCUGA.................... 1 1 hsa-mir-25_R10 ES_Dicer ...............................................................UUGCACUUGUCUCGGUCUGA.................... 1 1 hsa-mir-25_R11 ES_Dicer .............................................................CAUUGCACUUGUCUCGGUC....................... 1 1 hsa-mir-25_R12 ES_Dicer .............................................................CAUUGCACUUGUCUCGGUCUGAC................... 1 1 hsa-mir-25_R13 J1_ES_demeth ............................................................GCAUUGCACUUGUCUCGGUCUGA.................... 1 1 hsa-mir-25_R14 J1_ES_demeth ...............................................................UUGCACUUGUCUCGGUCUGA.................... 1 1 hsa-mir-25_R15 J1_ES_untr .............................................................CAUUGCACUUGUCUCGGUCU...................... 1 1 hsa-mir-25_R16 J1_ES_untr hsa-mir-26a-1 chr3:37985879-37985995 + GCGAAGGCCGUGGCCUCGUUCAAGUAAUCCAGGAUAGGCUGUGCAGGUCCCAAUGGGCCUAUUCUUGGUUACUUGCACGGGGACGCGGGCCUGGAC ....((((((((.((((((.(((((((((.((((((((((.((.......))...)))))))))).))))))))).)))))).))).))))).... (-48.50) ..................UUCAAGUAAUCCAGGAUAGGCU........................................................ 1122 2 hsa-mir-26a-1_L01_M J1_ES_demeth ..................UUCAAGUAAUCCAGGAUAGGCU........................................................ 686 2 hsa-mir-26a-1_L02 J1_ES_untr ..................UUCAAGUAAUCCAGGAUAGGC......................................................... 86 2 hsa-mir-26a-1_L03 J1_ES_demeth ..................UUCAAGUAAUCCAGGAUAGGCU........................................................ 63 2 hsa-mir-26a-1_L04 ES_Dicer ..................UUCAAGUAAUCCAGGAUAGGC......................................................... 42 2 hsa-mir-26a-1_L05 J1_ES_untr ...................UCAAGUAAUCCAGGAUAGGCU........................................................ 8 2 hsa-mir-26a-1_L06 J1_ES_demeth ..................UUCAAGUAAUCCAGGAUAGGC......................................................... 7 2 hsa-mir-26a-1_L07 ES_Dicer ..................UUCAAGUAAUCCAGGAUAG........................................................... 4 2 hsa-mir-26a-1_L08 J1_ES_demeth .................GUUCAAGUAAUCCAGGAUAGGCU........................................................ 2 1 hsa-mir-26a-1_L09 J1_ES_demeth ..................UUCAAGUAAUCCAGGAUAG........................................................... 1 2 hsa-mir-26a-1_L10 ES_Dicer ..................UUCAAGUAAUCCAGGAUAGGCUG....................................................... 1 2 hsa-mir-26a-1_L11 J1_ES_untr ...................UCAAGUAAUCCAGGAUAGGCU........................................................ 1 2 hsa-mir-26a-1_L12 J1_ES_untr ....................CAAGUAAUCCAGGAUAGGCU........................................................ 1 2 hsa-mir-26a-1_L13 J1_ES_demeth .....................AAGUAAUCCAGGAUAGGCU........................................................ 1 2 hsa-mir-26a-1_L14 J1_ES_demeth ......................AGUAAUCCAGGAUAGGCU........................................................ 1 2 hsa-mir-26a-1_L15 J1_ES_demeth hsa-mir-26a-2 chr12:56504639-56504762 - CUCCCAUAGAGGCUGUGGCUGGAUUCAAGUAAUCCAGGAUAGGCUGUUUCCAUCUGUGAGGCCUAUUCUUGAUUACUUGUUUCUGGAGGCAGCUGAUGGUCCG ...((((...((((((..(..((..(((((((((.((((((((((..............)))))))))).)))))))))..))..)..)))))).)))).... (-48.24) .......................UUCAAGUAAUCCAGGAUAGGCU.......................................................... 1122 2 hsa-mir-26a-2_L01_M J1_ES_demeth .......................UUCAAGUAAUCCAGGAUAGGCU.......................................................... 686 2 hsa-mir-26a-2_L02 J1_ES_untr .......................UUCAAGUAAUCCAGGAUAGGC........................................................... 86 2 hsa-mir-26a-2_L03 J1_ES_demeth .......................UUCAAGUAAUCCAGGAUAGGCU.......................................................... 63 2 hsa-mir-26a-2_L04 ES_Dicer .......................UUCAAGUAAUCCAGGAUAGGC........................................................... 42 2 hsa-mir-26a-2_L05 J1_ES_untr ........................UCAAGUAAUCCAGGAUAGGCU.......................................................... 8 2 hsa-mir-26a-2_L06 J1_ES_demeth .......................UUCAAGUAAUCCAGGAUAGGC........................................................... 7 2 hsa-mir-26a-2_L07 ES_Dicer .......................UUCAAGUAAUCCAGGAUAG............................................................. 4 2 hsa-mir-26a-2_L08 J1_ES_demeth ......................AUUCAAGUAAUCCAGGAUAGGCU.......................................................... 2 1 hsa-mir-26a-2_L09 ES_Dicer .......................UUCAAGUAAUCCAGGAUAG............................................................. 1 2 hsa-mir-26a-2_L10 ES_Dicer .......................UUCAAGUAAUCCAGGAUAGGCUG......................................................... 1 2 hsa-mir-26a-2_L11 J1_ES_untr ........................UCAAGUAAUCCAGGAUAGGCU.......................................................... 1 2 hsa-mir-26a-2_L12 J1_ES_untr .........................CAAGUAAUCCAGGAUAGGCU.......................................................... 1 2 hsa-mir-26a-2_L13 J1_ES_demeth ..........................AAGUAAUCCAGGAUAGGCU.......................................................... 1 2 hsa-mir-26a-2_L14 J1_ES_demeth ...........................AGUAAUCCAGGAUAGGCU.......................................................... 1 2 hsa-mir-26a-2_L15 J1_ES_demeth hsa-mir-26b chr2:218975593-218975709 + CCACCCUGCCCGGGACCCAGUUCAAGUAAUUCAGGAUAGGUUGUGUGCUGUCCAGCCUGUUCUCCAUUACUUGGCUCGGGGACCGGUGCCCUGCAG .......((((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..)))).))....... (-43.80) ....................UUCAAGUAAUUCAGGAUAGGUU...................................................... 657 1 hsa-mir-26b_L01_M J1_ES_demeth ....................UUCAAGUAAUUCAGGAUAGGUU...................................................... 296 1 hsa-mir-26b_L02 J1_ES_untr ....................UUCAAGUAAUUCAGGAUAGGU....................................................... 53 1 hsa-mir-26b_L03 J1_ES_demeth ....................UUCAAGUAAUUCAGGAUAGGUU...................................................... 28 1 hsa-mir-26b_L04 ES_Dicer ....................UUCAAGUAAUUCAGGAUAGGU....................................................... 19 1 hsa-mir-26b_L05 J1_ES_untr ....................UUCAAGUAAUUCAGGAUAGGUUG..................................................... 5 1 hsa-mir-26b_L06 J1_ES_demeth .....................UCAAGUAAUUCAGGAUAGGUU...................................................... 3 1 hsa-mir-26b_L07 J1_ES_demeth ....................UUCAAGUAAUUCAGGAUAGGU....................................................... 1 1 hsa-mir-26b_L08 ES_Dicer .....................UCAAGUAAUUCAGGAUAGGUU...................................................... 1 1 hsa-mir-26b_L09 J1_ES_untr ....................UUCAAGUAAUUCAGGAUA.......................................................... 1 1 hsa-mir-26b_L10 J1_ES_demeth .......................AAGUAAUUCAGGAUAGGUU...................................................... 1 1 hsa-mir-26b_L11 J1_ES_demeth hsa-mir-27a chr19:13808234-13808351 - CUGUGCCUGGCCUGAGGAGCAGGGCUUAGCUGCUUGUGAGCAGGGUCCACACCAAGUCGUGUUCACAGUGGCUAAGUUCCGCCCCCCAGGCCCUCACC ..(((...((((((.((.((.(((((((((..((.(((((((.((.(........))).)))))))))..))))))))).)).)).))))))..))). (-50.30) ....................AGGGCUUAGCUGCUUGUGA........................................................... 2 1 hsa-mir-27a_L01*_M ES_Dicer ....................AGGGCUUAGCUGCUUGUGAGCA........................................................ 1 1 hsa-mir-27a_L02* J1_ES_demeth .............................................................UUCACAGUGGCUAAGUUCCGC................ 428 1 hsa-mir-27a_R01_M J1_ES_demeth .............................................................UUCACAGUGGCUAAGUUCCGC................ 256 1 hsa-mir-27a_R02 J1_ES_untr .............................................................UUCACAGUGGCUAAGUUCCG................. 232 1 hsa-mir-27a_R03 J1_ES_demeth .............................................................UUCACAGUGGCUAAGUUCCGC................ 180 1 hsa-mir-27a_R04 ES_Dicer .............................................................UUCACAGUGGCUAAGUUCCG................. 60 1 hsa-mir-27a_R05 ES_Dicer .............................................................UUCACAGUGGCUAAGUUCCG................. 39 1 hsa-mir-27a_R06 J1_ES_untr .............................................................UUCACAGUGGCUAAGUUCC.................. 15 1 hsa-mir-27a_R07 J1_ES_demeth .............................................................UUCACAGUGGCUAAGUUC................... 7 2 hsa-mir-27a_R08 J1_ES_demeth ............................................................GUUCACAGUGGCUAAGUUCCGC................ 2 1 hsa-mir-27a_R09 J1_ES_untr ............................................................GUUCACAGUGGCUAAGUUCCGC................ 2 1 hsa-mir-27a_R10 J1_ES_demeth .............................................................UUCACAGUGGCUAAGUUCCGCC............... 1 1 hsa-mir-27a_R11 ES_Dicer ............................................................GUUCACAGUGGCUAAGUUCCG................. 1 1 hsa-mir-27a_R12 ES_Dicer .............................................................UUCACAGUGGCUAAGUUCC.................. 1 1 hsa-mir-27a_R13 J1_ES_untr ........................................................UCGUGUUCACAGUGGCUAAGU..................... 1 1 hsa-mir-27a_R14 J1_ES_demeth .............................................................UUCACAGUGGCUAAGUUCCGCC............... 1 1 hsa-mir-27a_R15 J1_ES_demeth ............................................................GUUCACAGUGGCUAAGUUCC.................. 1 1 hsa-mir-27a_R16 J1_ES_demeth hsa-mir-27b chr9:96887528-96887664 + CCAGCGAUGACCUCUCUAACAAGGUGCAGAGCUUAGCUGAUUGGUGAACAGUGAUUGGUUUCCGCUUUGUUCACAGUGGCUAAGUUCUGCACCUGAAGAGAAGGUGAGAUGGGGACAG (((....(.((((((((....((((((((((((((((((....((((((((....(((...)))..))))))))..))))))))))))))))))..)))).)))).)..)))...... (-55.10) ...........................AGAGCUUAGCUGAUUGGUGAACA.................................................................... 2 1 hsa-mir-27b_L01*_M J1_ES_demeth ...........................AGAGCUUAGCUGAUUGGUGAACAGU.................................................................. 1 1 hsa-mir-27b_L02* J1_ES_untr .....................................................................UUCACAGUGGCUAAGUUCUGC............................ 508 1 hsa-mir-27b_R01_M J1_ES_demeth .....................................................................UUCACAGUGGCUAAGUUCUGC............................ 329 1 hsa-mir-27b_R02 J1_ES_untr .....................................................................UUCACAGUGGCUAAGUUCUGC............................ 74 1 hsa-mir-27b_R03 ES_Dicer .....................................................................UUCACAGUGGCUAAGUUCUG............................. 46 1 hsa-mir-27b_R04 J1_ES_demeth .....................................................................UUCACAGUGGCUAAGUUCUGCA........................... 33 1 hsa-mir-27b_R05 J1_ES_demeth .....................................................................UUCACAGUGGCUAAGUUCUGCA........................... 29 1 hsa-mir-27b_R06 J1_ES_untr .....................................................................UUCACAGUGGCUAAGUUCUG............................. 11 1 hsa-mir-27b_R07 J1_ES_untr .....................................................................UUCACAGUGGCUAAGUUCUG............................. 10 1 hsa-mir-27b_R08 ES_Dicer ....................................................................GUUCACAGUGGCUAAGUUCUGC............................ 8 1 hsa-mir-27b_R09 J1_ES_demeth .....................................................................UUCACAGUGGCUAAGUUCU.............................. 8 1 hsa-mir-27b_R10 J1_ES_demeth .....................................................................UUCACAGUGGCUAAGUUC............................... 7 2 hsa-mir-27b_R11 J1_ES_demeth .....................................................................UUCACAGUGGCUAAGUUCUGCA........................... 3 1 hsa-mir-27b_R12 ES_Dicer ....................................................................GUUCACAGUGGCUAAGUUCUGC............................ 2 1 hsa-mir-27b_R13 J1_ES_untr .....................................................................UUCACAGUGGCUAAGUUCU.............................. 1 1 hsa-mir-27b_R14 ES_Dicer .....................................................................UUCACAGUGGCUAAGUUCU.............................. 1 1 hsa-mir-27b_R15 J1_ES_untr .....................................................................UUCACAGUGGCUAAGUUCUGCAC.......................... 1 1 hsa-mir-27b_R16 J1_ES_demeth ....................................................................GUUCACAGUGGCUAAGUUCU.............................. 1 1 hsa-mir-27b_R17 J1_ES_demeth ......................................................................UCACAGUGGCUAAGUUCUGC............................ 1 1 hsa-mir-27b_R18 J1_ES_demeth hsa-mir-28 chr3:189889243-189889368 + AUUUAAAAUGGUCCUUGCCCUCAAGGAGCUCACAGUCUAUUGAGUUACCUUUCUGACUUUCCCACUAGAUUGUGAGCUCCUGGAGGGCAGGCACUUUCGUUCAUC .........(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).))).......... (-50.90) ......................AAGGAGCUCACAGUCUAUUGAG............................................................. 208 1 hsa-mir-28_L01_M J1_ES_demeth ......................AAGGAGCUCACAGUCUAUUGAG............................................................. 87 1 hsa-mir-28_L02 J1_ES_untr ......................AAGGAGCUCACAGUCUAUUGA.............................................................. 39 1 hsa-mir-28_L03 J1_ES_demeth ......................AAGGAGCUCACAGUCUAUUGAGU............................................................ 11 1 hsa-mir-28_L04 J1_ES_demeth ......................AAGGAGCUCACAGUCUAUUGA.............................................................. 10 1 hsa-mir-28_L05 J1_ES_untr ......................AAGGAGCUCACAGUCUAUUGAG............................................................. 5 1 hsa-mir-28_L06 ES_Dicer ......................AAGGAGCUCACAGUCUAUUG............................................................... 5 1 hsa-mir-28_L07 J1_ES_demeth .....................CAAGGAGCUCACAGUCUAUUGA.............................................................. 4 1 hsa-mir-28_L08 J1_ES_demeth .....................CAAGGAGCUCACAGUCUAUUGAG............................................................. 3 1 hsa-mir-28_L09 J1_ES_demeth .......................AGGAGCUCACAGUCUAUUGAG............................................................. 2 1 hsa-mir-28_L10 ES_Dicer ......................AAGGAGCUCACAGUCUAUUGAGU............................................................ 2 1 hsa-mir-28_L11 ES_Dicer ......................AAGGAGCUCACAGUCUAUUGAGU............................................................ 2 1 hsa-mir-28_L12 J1_ES_untr .......................AGGAGCUCACAGUCUAUUGAG............................................................. 2 1 hsa-mir-28_L13 J1_ES_demeth ......................AAGGAGCUCACAGUCUAUUGA.............................................................. 1 1 hsa-mir-28_L14 ES_Dicer .......................AGGAGCUCACAGUCUAUUGAG............................................................. 1 1 hsa-mir-28_L15 J1_ES_untr hsa-mir-296 chr20:56826045-56826164 - GUGAGGAGAAAGGACCCUUCCAGAGGGCCCCCCCUCAAUCCUGUUGUGCCUAAUUCAGAGGGUUGGGUGGAGGCUCUCCUGAAGGGCUCUGAAGAGCGCUGCA (((.......((..((((((..(((((((.((.(((((((((.(((.........)))))))))))).)).)))))))..))))))..))......))).... (-45.22) .......................AGGGCCCCCCCUCAAUCCUGU........................................................... 29 1 hsa-mir-296_L01_M J1_ES_demeth .......................AGGGCCCCCCCUCAAUCCUGU........................................................... 2 1 hsa-mir-296_L02 J1_ES_untr .......................AGGGCCCCCCCUCAAUCCUG............................................................ 1 1 hsa-mir-296_L03 J1_ES_untr .........................................................GAGGGUUGGGUGGAGGCUCUCC........................ 16 1 hsa-mir-296_R01*_M ES_Dicer .........................................................GAGGGUUGGGUGGAGGCUCUC......................... 3 1 hsa-mir-296_R02* ES_Dicer .........................................................GAGGGUUGGGUGGAGGCUCUCC........................ 3 1 hsa-mir-296_R03* J1_ES_untr ..........................................................AGGGUUGGGUGGAGGCUCUCC........................ 1 1 hsa-mir-296_R04* ES_Dicer .........................................................GAGGGUUGGGUGGAGGCUCUCC........................ 1 1 hsa-mir-296_R05* J1_ES_demeth .........................................................GAGGGUUGGGUGGAGGCUCUC......................... 1 1 hsa-mir-296_R06* J1_ES_demeth hsa-mir-297 chr4:112001167-112001272 - UAUGAACAUAUGUAUGUAUGUGUGCAUGUGCAUGUAUGUGUAUAUACAUAUAUAUGUAUUAUGUACUCAUAUAUCAAGGAGAUUU ..........((.(((((((.((((((((((((((((((((....))))))))))))).))))))).)))))))))......... (-30.20) .............AUGUAUGUGUGCAUGUGCAUGU.................................................. 241 1 hsa-mir-297_L01_M J1_ES_untr .............AUGUAUGUGUGCAUGUGCAUGU.................................................. 207 1 hsa-mir-297_L02 ES_Dicer .............AUGUAUGUGUGCAUGUGCAUGU.................................................. 100 1 hsa-mir-297_L03 J1_ES_demeth .............AUGUAUGUGUGCAUGUGCAUG................................................... 50 1 hsa-mir-297_L04 ES_Dicer .............AUGUAUGUGUGCAUGUGCAU.................................................... 16 1 hsa-mir-297_L05 ES_Dicer .............AUGUAUGUGUGCAUGUGCAUG................................................... 16 1 hsa-mir-297_L06 J1_ES_untr .............AUGUAUGUGUGCAUGUGCAUG................................................... 7 1 hsa-mir-297_L07 J1_ES_demeth .............AUGUAUGUGUGCAUGUGCAUGUAU................................................ 5 1 hsa-mir-297_L08 J1_ES_demeth .............AUGUAUGUGUGCAUGUGCAUGUAU................................................ 4 1 hsa-mir-297_L09 J1_ES_untr .............AUGUAUGUGUGCAUGUGCAUGUA................................................. 4 1 hsa-mir-297_L10 J1_ES_untr .............AUGUAUGUGUGCAUGUGCAUGUA................................................. 4 1 hsa-mir-297_L11 J1_ES_demeth .............AUGUAUGUGUGCAUGUGCAU.................................................... 4 1 hsa-mir-297_L12 J1_ES_demeth ............UAUGUAUGUGUGCAUGUGCAUG................................................... 3 1 hsa-mir-297_L13 ES_Dicer ............UAUGUAUGUGUGCAUGUGCAUGU.................................................. 3 1 hsa-mir-297_L14 J1_ES_untr ............UAUGUAUGUGUGCAUGUGCAU.................................................... 3 1 hsa-mir-297_L15 J1_ES_demeth .............AUGUAUGUGUGCAUGUGCAUGUAU................................................ 2 1 hsa-mir-297_L16 ES_Dicer .............AUGUAUGUGUGCAUGUGCAU.................................................... 2 1 hsa-mir-297_L17 J1_ES_untr ...............GUAUGUGUGCAUGUGCAUG................................................... 1 1 hsa-mir-297_L18 ES_Dicer ..............UGUAUGUGUGCAUGUGCAUGU.................................................. 1 1 hsa-mir-297_L19 ES_Dicer ..............UGUAUGUGUGCAUGUGCAUG................................................... 1 1 hsa-mir-297_L20 ES_Dicer .............AUGUAUGUGUGCAUGUGCA..................................................... 1 1 hsa-mir-297_L21 ES_Dicer ............UAUGUAUGUGUGCAUGUGCAU.................................................... 1 1 hsa-mir-297_L22 ES_Dicer ................UAUGUGUGCAUGUGCAUG................................................... 1 1 hsa-mir-297_L23 ES_Dicer ............UAUGUAUGUGUGCAUGUGCAUGU.................................................. 1 1 hsa-mir-297_L24 J1_ES_demeth hsa-mir-299 chr14:100559864-100559966 + CGGUACUUGAAGAAAUGGUUUACCGUCCCACAUACAUUUUGAAUAUGUAUGUGGGAUGGUAAACCGCUUCUUGGUAUCCAGC .((((((..(((((.((((((((((((((((((((((.......)))))))))))))))))))))).))))))))))).... (-46.80) ...............UGGUUUACCGUCCCACAUACAU............................................. 95 1 hsa-mir-299_L01_M J1_ES_untr ...............UGGUUUACCGUCCCACAUACAU............................................. 51 1 hsa-mir-299_L02 J1_ES_demeth ...............UGGUUUACCGUCCCACAUACAU............................................. 34 1 hsa-mir-299_L03 ES_Dicer ..............AUGGUUUACCGUCCCACAUACA.............................................. 18 1 hsa-mir-299_L04 J1_ES_demeth ..............AUGGUUUACCGUCCCACAUACA.............................................. 9 1 hsa-mir-299_L05 J1_ES_untr ...............UGGUUUACCGUCCCACAUACA.............................................. 7 1 hsa-mir-299_L06 J1_ES_untr ...............UGGUUUACCGUCCCACAUACA.............................................. 7 1 hsa-mir-299_L07 J1_ES_demeth ...............UGGUUUACCGUCCCACAUACA.............................................. 6 1 hsa-mir-299_L08 ES_Dicer ..............AUGGUUUACCGUCCCACAUACA.............................................. 2 1 hsa-mir-299_L09 ES_Dicer ..............AUGGUUUACCGUCCCACAUAC............................................... 2 1 hsa-mir-299_L10 J1_ES_untr ...............UGGUUUACCGUCCCACAUACAUU............................................ 2 1 hsa-mir-299_L11 J1_ES_demeth ...............UGGUUUACCGUCCCACAUACAUU............................................ 1 1 hsa-mir-299_L12 J1_ES_untr ..............AUGGUUUACCGUCCCACAUAC............................................... 1 1 hsa-mir-299_L13 J1_ES_demeth hsa-mir-29a chr7:130212026-130212129 - CCCUUAGAGGAUGACUGAUUUCUUUUGGUGUUCAGAGUCAAUAUAAUUUUCUAGCACCAUCUGAAAUCGGUUAUAAUGAUUGG .((.......((((((((((((...(((((((.((((...........)))))))))))...)))))))))))).......)) (-27.24) .............ACUGAUUUCUUUUGGUGUUCAG................................................ 5 1 hsa-mir-29a_L01*_M J1_ES_demeth .............ACUGAUUUCUUUUGGUGUUCAGAG.............................................. 3 1 hsa-mir-29a_L02* J1_ES_demeth .............ACUGAUUUCUUUUGGUGUUCAGA............................................... 2 1 hsa-mir-29a_L03* J1_ES_demeth .............ACUGAUUUCUUUUGGUGUUCAGAGU............................................. 1 1 hsa-mir-29a_L04* ES_Dicer .............ACUGAUUUCUUUUGGUGUUCAG................................................ 1 1 hsa-mir-29a_L05* J1_ES_untr .............ACUGAUUUCUUUUGGUGUUCAGAGU............................................. 1 1 hsa-mir-29a_L06* J1_ES_demeth ...................................................UAGCACCAUCUGAAAUCGGUUA.......... 581 1 hsa-mir-29a_R01_M J1_ES_demeth ...................................................UAGCACCAUCUGAAAUCGGUUA.......... 297 1 hsa-mir-29a_R02 J1_ES_untr ...................................................UAGCACCAUCUGAAAUCGGUU........... 46 1 hsa-mir-29a_R03 J1_ES_demeth ...................................................UAGCACCAUCUGAAAUCGGUUA.......... 28 1 hsa-mir-29a_R04 ES_Dicer ...................................................UAGCACCAUCUGAAAUCGGUU........... 16 1 hsa-mir-29a_R05 J1_ES_untr ..................................................CUAGCACCAUCUGAAAUCGGUUA.......... 15 1 hsa-mir-29a_R06 J1_ES_demeth ...................................................UAGCACCAUCUGAAAUCGGUUAU......... 8 1 hsa-mir-29a_R07 J1_ES_demeth ...................................................UAGCACCAUCUGAAAUCGGUU........... 7 1 hsa-mir-29a_R08 ES_Dicer ...................................................UAGCACCAUCUGAAAUCGG............. 6 1 hsa-mir-29a_R09 ES_Dicer ..................................................CUAGCACCAUCUGAAAUCGGUU........... 6 1 hsa-mir-29a_R10 J1_ES_demeth ..................................................CUAGCACCAUCUGAAAUCGGUU........... 2 1 hsa-mir-29a_R11 J1_ES_untr ...................................................UAGCACCAUCUGAAAUCGGUUAU......... 2 1 hsa-mir-29a_R12 J1_ES_untr ..................................................CUAGCACCAUCUGAAAUCGGUUA.......... 2 1 hsa-mir-29a_R13 J1_ES_untr ..................................................CUAGCACCAUCUGAAAUCGGUUAU......... 2 1 hsa-mir-29a_R14 J1_ES_demeth ...................................................UAGCACCAUCUGAAAUCGGUUAU......... 1 1 hsa-mir-29a_R15 ES_Dicer hsa-mir-29b-1 chr7:130212738-130212858 - CAUAAAGCUUCUUCAGGAAGCUGGUUUCAUAUGGUGGUUUAGAUUUAAAUAGUGAUUGUCUAGCACCAUUUGAAAUCAGUGUUCUUGGGGGAGACCAGCU .......((((((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))))))....... (-38.92) ............................................................UAGCACCAUUUGAAAUCAGUGUU................. 234 2 hsa-mir-29b-1_R01_M J1_ES_demeth ............................................................UAGCACCAUUUGAAAUCAGUGUU................. 105 2 hsa-mir-29b-1_R02 J1_ES_untr ............................................................UAGCACCAUUUGAAAUCAGUGUU................. 20 2 hsa-mir-29b-1_R03 ES_Dicer ............................................................UAGCACCAUUUGAAAUCAGUGU.................. 17 2 hsa-mir-29b-1_R04 J1_ES_demeth ............................................................UAGCACCAUUUGAAAUCAGU.................... 15 2 hsa-mir-29b-1_R05 ES_Dicer ............................................................UAGCACCAUUUGAAAUCAGUGU.................. 5 2 hsa-mir-29b-1_R06 J1_ES_untr ...........................................................CUAGCACCAUUUGAAAUCAGUGU.................. 2 2 hsa-mir-29b-1_R07 J1_ES_demeth ............................................................UAGCACCAUUUGAAAUCAGUG................... 2 2 hsa-mir-29b-1_R08 J1_ES_demeth ............................................................UAGCACCAUUUGAAAUCAGUGU.................. 1 2 hsa-mir-29b-1_R09 ES_Dicer ...........................................................CUAGCACCAUUUGAAAUCAGU.................... 1 2 hsa-mir-29b-1_R10 J1_ES_untr hsa-mir-29b-2 chr1:206042391-206042511 - AGAUCCUCUUCUUCUGGAAGCUGGUUUCACAUGGUGGCUUAGAUUUUUCCAUCUUUGUAUCUAGCACCAUUUGAAAUCAGUGUUUUAGGAGUAAGAAUUG ......(((((((((((((((((((((((.((((((.((.((((..............)))))))))))).)))))))))).))))))))).)))).... (-35.64) .....................UGGUUUCACAUGGUGGCUUAGA......................................................... 1 1 hsa-mir-29b-2_L01*_M J1_ES_untr ...................GCUGGUUUCACAUGGUGGCUUAGA......................................................... 1 1 hsa-mir-29b-2_L02* J1_ES_untr .............................................................UAGCACCAUUUGAAAUCAGUGUU................ 234 2 hsa-mir-29b-2_R01_M J1_ES_demeth .............................................................UAGCACCAUUUGAAAUCAGUGUU................ 105 2 hsa-mir-29b-2_R02 J1_ES_untr .............................................................UAGCACCAUUUGAAAUCAGUGUUU............... 27 1 hsa-mir-29b-2_R03 J1_ES_demeth .............................................................UAGCACCAUUUGAAAUCAGUGUU................ 20 2 hsa-mir-29b-2_R04 ES_Dicer .............................................................UAGCACCAUUUGAAAUCAGUGUUU............... 19 1 hsa-mir-29b-2_R05 J1_ES_untr .............................................................UAGCACCAUUUGAAAUCAGUGU................. 17 2 hsa-mir-29b-2_R06 J1_ES_demeth .............................................................UAGCACCAUUUGAAAUCAGU................... 15 2 hsa-mir-29b-2_R07 ES_Dicer .............................................................UAGCACCAUUUGAAAUCAGUGU................. 5 2 hsa-mir-29b-2_R08 J1_ES_untr ............................................................CUAGCACCAUUUGAAAUCAGUGU................. 2 2 hsa-mir-29b-2_R09 J1_ES_demeth .............................................................UAGCACCAUUUGAAAUCAGUG.................. 2 2 hsa-mir-29b-2_R10 J1_ES_demeth .............................................................UAGCACCAUUUGAAAUCAGUGUUU............... 1 1 hsa-mir-29b-2_R11 ES_Dicer .............................................................UAGCACCAUUUGAAAUCAGUGU................. 1 2 hsa-mir-29b-2_R12 ES_Dicer ............................................................CUAGCACCAUUUGAAAUCAGU................... 1 2 hsa-mir-29b-2_R13 J1_ES_untr hsa-mir-29c chr1:206041800-206041927 - CCACUGGCCCAUCUCUUACACAGGCUGACCGAUUUCUCCUGGUGUUCAGAGUCUGUUUUUGUCUAGCACCAUUUGAAAUCGGUUAUGAUGUAGGGGGAAAAGCAGCA ...(((.....(((((((((((...(((((((((((...((((((((((((.....)))))...)))))))...))))))))))))).))))))))).....))).. (-36.70) .........................UGACCGAUUUCUCCUGGUGUUCA........................................................... 1 1 hsa-mir-29c_L01*_M J1_ES_untr .........................UGACCGAUUUCUCCUGGUGUUC............................................................ 1 1 hsa-mir-29c_L02* J1_ES_demeth ..........................GACCGAUUUCUCCUGGUGUUC............................................................ 1 1 hsa-mir-29c_L03* J1_ES_demeth ...............................................................UAGCACCAUUUGAAAUCGGUUA...................... 141 1 hsa-mir-29c_R01_M J1_ES_demeth ...............................................................UAGCACCAUUUGAAAUCGGUUA...................... 63 1 hsa-mir-29c_R02 J1_ES_untr ...............................................................UAGCACCAUUUGAAAUCGGUUA...................... 7 1 hsa-mir-29c_R03 ES_Dicer ...............................................................UAGCACCAUUUGAAAUCGGUU....................... 3 1 hsa-mir-29c_R04 ES_Dicer ...............................................................UAGCACCAUUUGAAAUCGGUU....................... 3 1 hsa-mir-29c_R05 J1_ES_untr ...............................................................UAGCACCAUUUGAAAUCGGUUAU..................... 3 1 hsa-mir-29c_R06 J1_ES_demeth ...............................................................UAGCACCAUUUGAAAUCGG......................... 2 1 hsa-mir-29c_R07 ES_Dicer ...............................................................UAGCACCAUUUGAAAUCGGUU....................... 2 1 hsa-mir-29c_R08 J1_ES_demeth ...............................................................UAGCACCAUUUGAAAUCGGUUAU..................... 1 1 hsa-mir-29c_R09 J1_ES_untr hsa-mir-301a chr17:54583259-54583384 - CCUACUUAUUACUGCUAACGAAUGCUCUGACUUUAUUGCACUACUGUACUUUACAGCUAGCAGUGCAAUAGUAUUGUCAAAGCAUCUGAAAGCAGGAUGCACGCC ...........(((((..((.(((((.((((.((((((((((.(((((...))))).....))))))))))....)))).))))).))..))))).......... (-32.80) .......................GCUCUGACUUUAUUGCACUACU............................................................ 3 1 hsa-mir-301a_L01*_M J1_ES_demeth .......................GCUCUGACUUUAUUGCACUACU............................................................ 1 1 hsa-mir-301a_L02* J1_ES_untr .......................GCUCUGACUUUAUUGCACUAC............................................................. 1 1 hsa-mir-301a_L03* J1_ES_demeth .......................GCUCUGACUUUAUUGCACUA.............................................................. 1 1 hsa-mir-301a_L04* J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAGC...................... 168 1 hsa-mir-301a_R01_M J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAGCAU.................... 130 1 hsa-mir-301a_R02 J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAGCAU.................... 102 1 hsa-mir-301a_R03 J1_ES_untr ............................................................CAGUGCAAUAGUAUUGUCAAAGC...................... 93 1 hsa-mir-301a_R04 J1_ES_untr ............................................................CAGUGCAAUAGUAUUGUCAAAGCA..................... 35 1 hsa-mir-301a_R05 J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAG....................... 34 1 hsa-mir-301a_R06 J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAGCA..................... 17 1 hsa-mir-301a_R07 J1_ES_untr ............................................................CAGUGCAAUAGUAUUGUCAAAG....................... 14 1 hsa-mir-301a_R08 J1_ES_untr ............................................................CAGUGCAAUAGUAUUGUCAAAGC...................... 7 1 hsa-mir-301a_R09 ES_Dicer .............................................................AGUGCAAUAGUAUUGUCAAAGCAU.................... 7 1 hsa-mir-301a_R10 J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAG....................... 3 1 hsa-mir-301a_R11 ES_Dicer ...............................................................UGCAAUAGUAUUGUCAAAGC...................... 2 1 hsa-mir-301a_R12 J1_ES_demeth ............................................................CAGUGCAAUAGUAUUGUCAAAGCA..................... 1 1 hsa-mir-301a_R13 ES_Dicer ...............................................................UGCAAUAGUAUUGUCAAAGC...................... 1 1 hsa-mir-301a_R14 ES_Dicer ............................................................CAGUGCAAUAGUAUUGUCAAA........................ 1 1 hsa-mir-301a_R15 J1_ES_untr .............................................................AGUGCAAUAGUAUUGUCAAAGC...................... 1 1 hsa-mir-301a_R16 J1_ES_untr .............................................................AGUGCAAUAGUAUUGUCAAAGCAU.................... 1 1 hsa-mir-301a_R17 J1_ES_untr ............................................................CAGUGCAAUAGUAUUGUCA.......................... 1 1 hsa-mir-301a_R18 J1_ES_demeth ..............................................................GUGCAAUAGUAUUGUCAAAGC...................... 1 1 hsa-mir-301a_R19 J1_ES_demeth hsa-mir-302a chr4:113788768-113788876 - CCAAGACUGGGCUCCCCACCACUUAAACGUGGAUGUACUUGCUUUGAAACUAAAGAAGUAAGUGCUUCCAUGUUUUGGUGAUGGUAAGUCUUCC ........(((((..(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))..)))))... (-41.00) ..........................................................UAAGUGCUUCCAUGUUUUGGUGA............. 40 1 hsa-mir-302a_R01_M J1_ES_untr ..........................................................UAAGUGCUUCCAUGUUUUGGUGA............. 29 1 hsa-mir-302a_R02 ES_Dicer ...........................................................AAGUGCUUCCAUGUUUUGGUGA............. 9 1 hsa-mir-302a_R03 J1_ES_untr ...........................................................AAGUGCUUCCAUGUUUUGGUGA............. 4 1 hsa-mir-302a_R04 ES_Dicer ..........................................................UAAGUGCUUCCAUGUUUUGGUGA............. 4 1 hsa-mir-302a_R05 J1_ES_demeth ..........................................................UAAGUGCUUCCAUGUUUUGGU............... 3 1 hsa-mir-302a_R06 ES_Dicer ...........................................................AAGUGCUUCCAUGUUUUGGUGA............. 2 1 hsa-mir-302a_R07 J1_ES_demeth ..........................................................UAAGUGCUUCCAUGUUUUGG................ 1 1 hsa-mir-302a_R08 ES_Dicer ..........................................................UAAGUGCUUCCAUGUUUUGGU............... 1 1 hsa-mir-302a_R09 J1_ES_untr ............................................................AGUGCUUCCAUGUUUUGGUGA............. 1 1 hsa-mir-302a_R10 J1_ES_demeth hsa-mir-302b chr4:113789070-113789182 - AAGUUGUAUGUUGGGUGGGCUCCCUUCAACUUUAACAUGGAAGUGCUUUCUGUGACUUUAAAAGUAAGUGCUUCCAUGUUUUAGUAGGAGUGAAUCCAAU .........(((((((..(((((.....(((..((((((((((..(((.((...........)).)))..))))))))))..))).)))))..))))))) (-38.80) ................................................................UAAGUGCUUCCAUGUUUUAGUAG............. 52 1 hsa-mir-302b_R01_M J1_ES_untr ................................................................UAAGUGCUUCCAUGUUUUAGUAG............. 29 1 hsa-mir-302b_R02 ES_Dicer ................................................................UAAGUGCUUCCAUGUUUUAGUAG............. 14 1 hsa-mir-302b_R03 J1_ES_demeth ................................................................UAAGUGCUUCCAUGUUUUAGU............... 8 1 hsa-mir-302b_R04 J1_ES_untr ................................................................UAAGUGCUUCCAUGUUUUAGUA.............. 7 1 hsa-mir-302b_R05 ES_Dicer .................................................................AAGUGCUUCCAUGUUUUAGUAG............. 6 1 hsa-mir-302b_R06 ES_Dicer .................................................................AAGUGCUUCCAUGUUUUAGUAG............. 5 1 hsa-mir-302b_R07 J1_ES_untr ................................................................UAAGUGCUUCCAUGUUUUAGUA.............. 5 1 hsa-mir-302b_R08 J1_ES_untr ................................................................UAAGUGCUUCCAUGUUUUAGU............... 4 1 hsa-mir-302b_R09 ES_Dicer ................................................................UAAGUGCUUCCAUGUUUUAG................ 3 1 hsa-mir-302b_R10 ES_Dicer ..................................................................AGUGCUUCCAUGUUUUAGUA.............. 1 1 hsa-mir-302b_R11 ES_Dicer .................................................................AAGUGCUUCCAUGUUUUAGUA.............. 1 1 hsa-mir-302b_R12 J1_ES_untr ................................................................UAAGUGCUUCCAUGUUUUAG................ 1 1 hsa-mir-302b_R13 J1_ES_demeth ................................................................UAAGUGCUUCCAUGUUUUAGU............... 1 1 hsa-mir-302b_R14 J1_ES_demeth .................................................................AAGUGCUUCCAUGUUUUAGUAG............. 1 1 hsa-mir-302b_R15 J1_ES_demeth hsa-mir-302c chr4:113788948-113789055 - UUGAAGGGAUCCCCUUUGCUUUAACAUGGGGGUACCUGCUGUGUGAAACAAAAGUAAGUGCUUCCAUGUUUCAGUGGAGGUGUCUCCAA ......(((..(((((..((..(((((((((((((.((((.((.....))..)))).)))))))))))))..))..)))).)..))).. (-38.30) .......................................................AAGUGCUUCCAUGUUUCAGUGG............ 5 1 hsa-mir-302c_R01_M ES_Dicer .......................................................AAGUGCUUCCAUGUUUCAGUGG............ 4 1 hsa-mir-302c_R02 J1_ES_demeth .......................................................AAGUGCUUCCAUGUUUCAGU.............. 2 1 hsa-mir-302c_R03 ES_Dicer .......................................................AAGUGCUUCCAUGUUUCAGUGGA........... 1 1 hsa-mir-302c_R04 ES_Dicer .......................................................AAGUGCUUCCAUGUUUCAGUG............. 1 1 hsa-mir-302c_R05 ES_Dicer .......................................................AAGUGCUUCCAUGUUUCAGUGG............ 1 1 hsa-mir-302c_R06 J1_ES_untr .......................................................AAGUGCUUCCAUGUUUCAGUGGA........... 1 1 hsa-mir-302c_R07 J1_ES_demeth ........................................................AGUGCUUCCAUGUUUCAGUGG............ 1 1 hsa-mir-302c_R08 J1_ES_demeth hsa-mir-302d chr4:113788589-113788696 - UAAGGGGCCCCCUCUACUUUAACAUGGAGGCACUUGCUGUGACAUGACAAAAAUAAGUGCUUCCAUGUUUGAGUGUGGUGGUUCCUAC ..(((((((.((.(.((((.((((((((((((((((.(((......)))....)))))))))))))))).))))).)).))))))).. (-42.40) ...............ACUUUAACAUGGAGGCACUUGCU.................................................. 18 1 hsa-mir-302d_L01*_M J1_ES_untr ..............UACUUUAACAUGGAGGCACUUGCU.................................................. 12 1 hsa-mir-302d_L02* J1_ES_untr ..............UACUUUAACAUGGAGGCACUUGC................................................... 10 1 hsa-mir-302d_L03* J1_ES_untr ...............ACUUUAACAUGGAGGCACUUGCU.................................................. 4 1 hsa-mir-302d_L04* J1_ES_demeth ...............ACUUUAACAUGGAGGCACUUGC................................................... 2 1 hsa-mir-302d_L05* J1_ES_untr ...............ACUUUAACAUGGAGGCACUUG.................................................... 2 1 hsa-mir-302d_L06* J1_ES_untr ..............UACUUUAACAUGGAGGCACUUGCU.................................................. 2 1 hsa-mir-302d_L07* J1_ES_demeth ..............UACUUUAACAUGGAGGCACUUGC................................................... 1 1 hsa-mir-302d_L08* ES_Dicer ...............ACUUUAACAUGGAGGCACUU..................................................... 1 1 hsa-mir-302d_L09* J1_ES_untr ..............UACUUUAACAUGGAGGCACUUG.................................................... 1 1 hsa-mir-302d_L10* J1_ES_untr ..............UACUUUAACAUGGAGGCACUUG.................................................... 1 1 hsa-mir-302d_L11* J1_ES_demeth ...............ACUUUAACAUGGAGGCACUUG.................................................... 1 1 hsa-mir-302d_L12* J1_ES_demeth ...............ACUUUAACAUGGAGGCACUUGC................................................... 1 1 hsa-mir-302d_L13* J1_ES_demeth .....................................................UAAGUGCUUCCAUGUUUGAGUGU............ 110 1 hsa-mir-302d_R01_M ES_Dicer .....................................................UAAGUGCUUCCAUGUUUGAGUGU............ 60 1 hsa-mir-302d_R02 J1_ES_untr .....................................................UAAGUGCUUCCAUGUUUGAGUG............. 38 1 hsa-mir-302d_R03 ES_Dicer .....................................................UAAGUGCUUCCAUGUUUGAGUG............. 7 1 hsa-mir-302d_R04 J1_ES_untr ......................................................AAGUGCUUCCAUGUUUGAGUGU............ 4 1 hsa-mir-302d_R05 ES_Dicer ......................................................AAGUGCUUCCAUGUUUGAGUGU............ 3 1 hsa-mir-302d_R06 J1_ES_untr .....................................................UAAGUGCUUCCAUGUUUGAGU.............. 3 1 hsa-mir-302d_R07 J1_ES_untr .......................................................AGUGCUUCCAUGUUUGAGUGU............ 3 1 hsa-mir-302d_R08 J1_ES_untr .....................................................UAAGUGCUUCCAUGUUUGAG............... 2 1 hsa-mir-302d_R09 ES_Dicer .....................................................UAAGUGCUUCCAUGUUUGAGUGU............ 2 1 hsa-mir-302d_R10 J1_ES_demeth .....................................................UAAGUGCUUCCAUGUUUGAGUG............. 2 1 hsa-mir-302d_R11 J1_ES_demeth hsa-mir-30a chr6:72169955-72170065 - UUGACAGUGAGCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGCCUACUGCCU ....(((((.(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).))).)))))... (-44.50) ...............UGUAAACAUCCUCGACUGGAAGCU................................................... 95 1 hsa-mir-30a_L01_M J1_ES_demeth ...............UGUAAACAUCCUCGACUGGAAGCU................................................... 77 1 hsa-mir-30a_L02 J1_ES_untr ...............UGUAAACAUCCUCGACUGGAAGC.................................................... 60 1 hsa-mir-30a_L03 J1_ES_demeth ...............UGUAAACAUCCUCGACUGGAAGC.................................................... 35 1 hsa-mir-30a_L04 J1_ES_untr ...............UGUAAACAUCCUCGACUGGAAG..................................................... 34 1 hsa-mir-30a_L05 J1_ES_demeth ...............UGUAAACAUCCUCGACUGGAAG..................................................... 25 1 hsa-mir-30a_L06 J1_ES_untr ...............UGUAAACAUCCUCGACUGGAA...................................................... 15 1 hsa-mir-30a_L07 J1_ES_demeth ...............UGUAAACAUCCUCGACUGGAAG..................................................... 14 1 hsa-mir-30a_L08 ES_Dicer ...............UGUAAACAUCCUCGACUGGAAGCU................................................... 9 1 hsa-mir-30a_L09 ES_Dicer ...............UGUAAACAUCCUCGACUGGAAGC.................................................... 5 1 hsa-mir-30a_L10 ES_Dicer ...............UGUAAACAUCCUCGACUGGAA...................................................... 5 1 hsa-mir-30a_L11 J1_ES_untr ................GUAAACAUCCUCGACUGGAAGCU................................................... 4 1 hsa-mir-30a_L12 J1_ES_demeth ...............UGUAAACAUCCUCGACUGGA....................................................... 4 1 hsa-mir-30a_L13 J1_ES_demeth ................GUAAACAUCCUCGACUGGAAGC.................................................... 4 1 hsa-mir-30a_L14 J1_ES_demeth ...............UGUAAACAUCCUCGACUGGAA...................................................... 4 1 hsa-mir-30a_L15 ES_Dicer-DEL ................GUAAACAUCCUCGACUGGAAG..................................................... 1 1 hsa-mir-30a_L16 J1_ES_untr ........................................................CUUUCAGUCGGAUGUUUGCAGC............ 9 1 hsa-mir-30a_R01*_M J1_ES_demeth ........................................................CUUUCAGUCGGAUGUUUGCAG............. 8 1 hsa-mir-30a_R02* J1_ES_demeth ........................................................CUUUCAGUCGGAUGUUUGCAGC............ 7 1 hsa-mir-30a_R03* J1_ES_untr ........................................................CUUUCAGUCGGAUGUUUGCAGC............ 3 1 hsa-mir-30a_R04* ES_Dicer .........................................................UUUCAGUCGGAUGUUUGCAG............. 3 1 hsa-mir-30a_R05* J1_ES_demeth ........................................................CUUUCAGUCGGAUGUUUGCA.............. 1 1 hsa-mir-30a_R06* ES_Dicer .........................................................UUUCAGUCGGAUGUUUGCA.............. 1 1 hsa-mir-30a_R07* J1_ES_untr .........................................................UUUCAGUCGGAUGUUUGCAG............. 1 1 hsa-mir-30a_R08* J1_ES_untr hsa-mir-30b chr8:135881925-135882052 - AGUCCUGCUUUAAACCAAGUUUCAGUUCAUGUAAACAUCCUACACUCAGCUGUAAUACAUGGAUUGGCUGGGAGGUGGAUGUUUACUUCAGCUGACUUGGAAUGUCAACCAAU ..............(((((..((((((...((((((((((.((.((((((((............))))))))..))))))))))))...)))))))))))............. (-37.60) .............................UGUAAACAUCCUACACUCAGCU.............................................................. 1987 1 hsa-mir-30b_L01_M J1_ES_demeth .............................UGUAAACAUCCUACACUCAGCU.............................................................. 1365 1 hsa-mir-30b_L02 J1_ES_untr .............................UGUAAACAUCCUACACUCAGCU.............................................................. 198 1 hsa-mir-30b_L03 ES_Dicer .............................UGUAAACAUCCUACACUCAGC............................................................... 142 1 hsa-mir-30b_L04 J1_ES_demeth .............................UGUAAACAUCCUACACUCAGC............................................................... 75 1 hsa-mir-30b_L05 J1_ES_untr .............................UGUAAACAUCCUACACUCAGC............................................................... 14 1 hsa-mir-30b_L06 ES_Dicer .............................UGUAAACAUCCUACACUCAG................................................................ 10 1 hsa-mir-30b_L07 J1_ES_demeth .............................UGUAAACAUCCUACACUCAGCUG............................................................. 7 1 hsa-mir-30b_L08 J1_ES_demeth ............................AUGUAAACAUCCUACACUCAGCU.............................................................. 3 1 hsa-mir-30b_L09 ES_Dicer .............................UGUAAACAUCCUACACUCA................................................................. 2 1 hsa-mir-30b_L10 J1_ES_demeth ...............................UAAACAUCCUACACUCAGCU.............................................................. 2 1 hsa-mir-30b_L11 J1_ES_demeth .............................UGUAAACAUCCUACACUCAGCUG............................................................. 2 1 hsa-mir-30b_L12 J1_ES_untr ..............................GUAAACAUCCUACACUCAGCU.............................................................. 2 1 hsa-mir-30b_L13 J1_ES_untr ...............................UAAACAUCCUACACUCAGCU.............................................................. 1 1 hsa-mir-30b_L14 ES_Dicer ................................AAACAUCCUACACUCAGCU.............................................................. 1 1 hsa-mir-30b_L15 ES_Dicer .............................UGUAAACAUCCUACACUCAG................................................................ 1 1 hsa-mir-30b_L16 ES_Dicer .............................UGUAAACAUCCUACACUC.................................................................. 1 3 hsa-mir-30b_L17 ES_Dicer ..............................GUAAACAUCCUACACUCAGCU.............................................................. 1 1 hsa-mir-30b_L18 J1_ES_demeth .............................UGUAAACAUCCUACACUCAG................................................................ 1 1 hsa-mir-30b_L19 J1_ES_untr ...............................UAAACAUCCUACACUCAGCU.............................................................. 1 1 hsa-mir-30b_L20 J1_ES_untr .............................UGUAAACAUCCUACACUCAGCU.............................................................. 1 1 hsa-mir-30b_L21 ES_Dicer-DEL hsa-mir-30c-1 chr1:40995523-40995651 + UGGGCUAUAACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGAAAACAUCAGC ((((((...((...((((.((.(((((.........))))).)))))).)).))))))..(((((.(((((.((((.....))))))))))))))............. (-35.70) .........................UGUAAACAUCCUACACUCUCAGCU........................................................... 2958 2 hsa-mir-30c-1_L01_M J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGCU........................................................... 1873 2 hsa-mir-30c-1_L02 J1_ES_untr .........................UGUAAACAUCCUACACUCUCAGC............................................................ 572 2 hsa-mir-30c-1_L03 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGC............................................................ 467 2 hsa-mir-30c-1_L04 J1_ES_untr .........................UGUAAACAUCCUACACUCUCAG............................................................. 207 2 hsa-mir-30c-1_L05 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCA.............................................................. 103 2 hsa-mir-30c-1_L06 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGCU........................................................... 89 2 hsa-mir-30c-1_L07 ES_Dicer .........................UGUAAACAUCCUACACUCUCAG............................................................. 88 2 hsa-mir-30c-1_L08 J1_ES_untr .........................UGUAAACAUCCUACACUCUCAGC............................................................ 41 2 hsa-mir-30c-1_L09 ES_Dicer .........................UGUAAACAUCCUACACUCUCAG............................................................. 38 2 hsa-mir-30c-1_L10 ES_Dicer .........................UGUAAACAUCCUACACUCUCA.............................................................. 26 2 hsa-mir-30c-1_L11 J1_ES_untr ........................GUGUAAACAUCCUACACUCUCAGCU........................................................... 14 1 hsa-mir-30c-1_L12 J1_ES_demeth ........................GUGUAAACAUCCUACACUCUCAGCU........................................................... 11 1 hsa-mir-30c-1_L13 J1_ES_untr .........................UGUAAACAUCCUACACUCUCA.............................................................. 10 2 hsa-mir-30c-1_L14 ES_Dicer .........................UGUAAACAUCCUACACUCU................................................................ 10 2 hsa-mir-30c-1_L15 J1_ES_demeth .........................UGUAAACAUCCUACACUCUC............................................................... 6 2 hsa-mir-30c-1_L16 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGCUG.......................................................... 6 2 hsa-mir-30c-1_L17 J1_ES_untr ........................GUGUAAACAUCCUACACUCUCAGC............................................................ 4 1 hsa-mir-30c-1_L18 J1_ES_demeth .........................UGUAAACAUCCUACACUCUC............................................................... 4 2 hsa-mir-30c-1_L19 J1_ES_untr ..........................GUAAACAUCCUACACUCUCAGC............................................................ 3 2 hsa-mir-30c-1_L20 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGCUG.......................................................... 3 2 hsa-mir-30c-1_L21 J1_ES_demeth ........................GUGUAAACAUCCUACACUCUCAGC............................................................ 3 1 hsa-mir-30c-1_L22 J1_ES_untr .........................UGUAAACAUCCUACACUCU................................................................ 2 2 hsa-mir-30c-1_L23 ES_Dicer ...........................UAAACAUCCUACACUCUCAGCU........................................................... 2 2 hsa-mir-30c-1_L24 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGCUGU......................................................... 2 2 hsa-mir-30c-1_L25 J1_ES_untr ........................GUGUAAACAUCCUACACUCUCAGC............................................................ 1 1 hsa-mir-30c-1_L26 ES_Dicer .........................UGUAAACAUCCUACACUC................................................................. 1 3 hsa-mir-30c-1_L27 ES_Dicer .........................UGUAAACAUCCUACACUCUC............................................................... 1 2 hsa-mir-30c-1_L28 ES_Dicer ............................AAACAUCCUACACUCUCAGCU........................................................... 1 2 hsa-mir-30c-1_L29 ES_Dicer ........................GUGUAAACAUCCUACACUCUCAGCU........................................................... 1 1 hsa-mir-30c-1_L30 ES_Dicer ........................GUGUAAACAUCCUACACUCUCA.............................................................. 1 1 hsa-mir-30c-1_L31 J1_ES_demeth ............................AAACAUCCUACACUCUCAGC............................................................ 1 2 hsa-mir-30c-1_L32 J1_ES_demeth .........................UGUAAACAUCCUACACUCUCAGCUGU......................................................... 1 2 hsa-mir-30c-1_L33 J1_ES_demeth ...........................UAAACAUCCUACACUCUCAG............................................................. 1 2 hsa-mir-30c-1_L34 J1_ES_demeth ..........................GUAAACAUCCUACACUCUCAGCU........................................................... 1 2 hsa-mir-30c-1_L35 J1_ES_demeth ..........................GUAAACAUCCUACACUCUCAGCU........................................................... 1 2 hsa-mir-30c-1_L36 J1_ES_untr ........................GUGUAAACAUCCUACACUCUCAG............................................................. 1 1 hsa-mir-30c-1_L37 J1_ES_untr .........................UGUAAACAUCCUACACUCUCAGCUGU......................................................... 1 2 hsa-mir-30c-1_L38 ES_Dicer-DEL ................................................................CUGGGAGAGGGUUGUUUACUCC...................... 3 1 hsa-mir-30c-1_R01*_M J1_ES_demeth ................................................................CUGGGAGAGGGUUGUUUACU........................ 1 1 hsa-mir-30c-1_R02* J1_ES_demeth ................................................................CUGGGAGAGGGUUGUUUACUCC...................... 1 1 hsa-mir-30c-1_R03* J1_ES_untr hsa-mir-30c-2 chr6:72143364-72143475 - ACUGAGCGACAGAUACUGUAAACAUCCUACACUCUCAGCUGUGGAAAGUAAGAAAGCUGGGAGAAGGCUGUUUACUCUUUCUGCCUUGGAA .(..((.(.((((....(((((((.(((...(((((((((..............))))))))).))).)))))))....)))))))..).. (-34.14) ................UGUAAACAUCCUACACUCUCAGCU................................................... 2958 2 hsa-mir-30c-2_L01_M J1_ES_demeth ................UGUAAACAUCCUACACUCUCAGCU................................................... 1873 2 hsa-mir-30c-2_L02 J1_ES_untr ................UGUAAACAUCCUACACUCUCAGC.................................................... 572 2 hsa-mir-30c-2_L03 J1_ES_demeth ................UGUAAACAUCCUACACUCUCAGC.................................................... 467 2 hsa-mir-30c-2_L04 J1_ES_untr ................UGUAAACAUCCUACACUCUCAG..................................................... 207 2 hsa-mir-30c-2_L05 J1_ES_demeth ................UGUAAACAUCCUACACUCUCA...................................................... 103 2 hsa-mir-30c-2_L06 J1_ES_demeth ................UGUAAACAUCCUACACUCUCAGCU................................................... 89 2 hsa-mir-30c-2_L07 ES_Dicer ................UGUAAACAUCCUACACUCUCAG..................................................... 88 2 hsa-mir-30c-2_L08 J1_ES_untr ................UGUAAACAUCCUACACUCUCAGC.................................................... 41 2 hsa-mir-30c-2_L09 ES_Dicer ................UGUAAACAUCCUACACUCUCAG..................................................... 38 2 hsa-mir-30c-2_L10 ES_Dicer ................UGUAAACAUCCUACACUCUCA...................................................... 26 2 hsa-mir-30c-2_L11 J1_ES_untr ................UGUAAACAUCCUACACUCUCA...................................................... 10 2 hsa-mir-30c-2_L12 ES_Dicer ................UGUAAACAUCCUACACUCU........................................................ 10 2 hsa-mir-30c-2_L13 J1_ES_demeth ................UGUAAACAUCCUACACUCUC....................................................... 6 2 hsa-mir-30c-2_L14 J1_ES_demeth ................UGUAAACAUCCUACACUCUCAGCUG.................................................. 6 2 hsa-mir-30c-2_L15 J1_ES_untr ................UGUAAACAUCCUACACUCUC....................................................... 4 2 hsa-mir-30c-2_L16 J1_ES_untr .................GUAAACAUCCUACACUCUCAGC.................................................... 3 2 hsa-mir-30c-2_L17 J1_ES_demeth ................UGUAAACAUCCUACACUCUCAGCUG.................................................. 3 2 hsa-mir-30c-2_L18 J1_ES_demeth ................UGUAAACAUCCUACACUCU........................................................ 2 2 hsa-mir-30c-2_L19 ES_Dicer ..................UAAACAUCCUACACUCUCAGCU................................................... 2 2 hsa-mir-30c-2_L20 J1_ES_demeth ................UGUAAACAUCCUACACUCUCAGCUGU................................................. 2 2 hsa-mir-30c-2_L21 J1_ES_untr ................UGUAAACAUCCUACACUC......................................................... 1 3 hsa-mir-30c-2_L22 ES_Dicer ...................AAACAUCCUACACUCUCAGCU................................................... 1 2 hsa-mir-30c-2_L23 ES_Dicer ................UGUAAACAUCCUACACUCUC....................................................... 1 2 hsa-mir-30c-2_L24 ES_Dicer ................UGUAAACAUCCUACACUCUCAGCUGU................................................. 1 2 hsa-mir-30c-2_L25 J1_ES_demeth ...................AAACAUCCUACACUCUCAGC.................................................... 1 2 hsa-mir-30c-2_L26 J1_ES_demeth .................GUAAACAUCCUACACUCUCAGCU................................................... 1 2 hsa-mir-30c-2_L27 J1_ES_demeth ...............CUGUAAACAUCCUACACUCUCAGCU................................................... 1 1 hsa-mir-30c-2_L28 J1_ES_demeth ..................UAAACAUCCUACACUCUCAG..................................................... 1 2 hsa-mir-30c-2_L29 J1_ES_demeth .................GUAAACAUCCUACACUCUCAGCU................................................... 1 2 hsa-mir-30c-2_L30 J1_ES_untr ................UGUAAACAUCCUACACUCUCAGCUGU................................................. 1 2 hsa-mir-30c-2_L31 ES_Dicer-DEL ........................................................CUGGGAGAAGGCUGUUUACUCU............. 3 1 hsa-mir-30c-2_R01*_M J1_ES_demeth ........................................................CUGGGAGAAGGCUGUUUACUCU............. 1 1 hsa-mir-30c-2_R02* J1_ES_untr hsa-mir-30d chr8:135886281-135886390 - UUGUUCAGAAAGUCUGUUGUUGUAAACAUCCCCGACUGGAAGCUGUAAGACACAGCUAAGCUUUCAGUCAGAUGUUUGCUGCUACCGGCUAUUC .......(((((((.((.((.(((((((((...(((((((((((...((......)).))))))))))).))))))))).)).)).)))).))) (-34.30) ....................UGUAAACAUCCCCGACUGGAAGCU.................................................. 51 1 hsa-mir-30d_L01_M J1_ES_demeth ....................UGUAAACAUCCCCGACUGGAAGCU.................................................. 23 1 hsa-mir-30d_L02 J1_ES_untr ....................UGUAAACAUCCCCGACUGGAAGC................................................... 21 1 hsa-mir-30d_L03 J1_ES_demeth ....................UGUAAACAUCCCCGACUGGAAGC................................................... 16 1 hsa-mir-30d_L04 J1_ES_untr ....................UGUAAACAUCCCCGACUGGAAG.................................................... 16 1 hsa-mir-30d_L05 J1_ES_demeth ....................UGUAAACAUCCCCGACUGGAAG.................................................... 13 1 hsa-mir-30d_L06 J1_ES_untr ....................UGUAAACAUCCCCGACUGGAA..................................................... 9 1 hsa-mir-30d_L07 J1_ES_untr ....................UGUAAACAUCCCCGACUGGAAGC................................................... 4 1 hsa-mir-30d_L08 ES_Dicer ....................UGUAAACAUCCCCGACUGGAA..................................................... 4 1 hsa-mir-30d_L09 J1_ES_demeth ....................UGUAAACAUCCCCGACUGGAAGCU.................................................. 2 1 hsa-mir-30d_L10 ES_Dicer ....................UGUAAACAUCCCCGACUGGAAG.................................................... 2 1 hsa-mir-30d_L11 ES_Dicer ....................UGUAAACAUCCCCGACUGGA...................................................... 2 1 hsa-mir-30d_L12 J1_ES_demeth ....................UGUAAACAUCCCCGACUGGAA..................................................... 1 1 hsa-mir-30d_L13 ES_Dicer ....................UGUAAACAUCCCCGACUGGA...................................................... 1 1 hsa-mir-30d_L14 ES_Dicer ....................UGUAAACAUCCCCGACUGGA...................................................... 1 1 hsa-mir-30d_L15 J1_ES_untr ............................................................CUUUCAGUCAGAUGUUUGCUGC............ 3 1 hsa-mir-30d_R01*_M J1_ES_demeth ............................................................CUUUCAGUCAGAUGUUUGCUGC............ 1 1 hsa-mir-30d_R02* ES_Dicer hsa-mir-30e chr1:40992594-40992725 + CGUUCUUUCUGGGCAGUCUUUGCUACUGUAAACAUCCUUGACUGGAAGCUGUAAGGUGUUCAGAGGAGCUUUCAGUCGGAUGUUUACAGCGGCAGGCUGCCACGGUCGUCCCCA ........(((((((((((..((..((((((((((((..(((((((((((.(...(....)...).)))))))))))))))))))))))..)))))))))).)))......... (-55.00) ..........................UGUAAACAUCCUUGACUGGAAGCU................................................................ 167 1 hsa-mir-30e_L01_M J1_ES_demeth ..........................UGUAAACAUCCUUGACUGGAAGCU................................................................ 129 1 hsa-mir-30e_L02 J1_ES_untr ..........................UGUAAACAUCCUUGACUGGAAGC................................................................. 71 1 hsa-mir-30e_L03 J1_ES_demeth ..........................UGUAAACAUCCUUGACUGGAAGC................................................................. 63 1 hsa-mir-30e_L04 J1_ES_untr ..........................UGUAAACAUCCUUGACUGGAAG.................................................................. 25 1 hsa-mir-30e_L05 J1_ES_demeth ..........................UGUAAACAUCCUUGACUGGAAG.................................................................. 24 1 hsa-mir-30e_L06 ES_Dicer ..........................UGUAAACAUCCUUGACUGGAAGCU................................................................ 19 1 hsa-mir-30e_L07 ES_Dicer ..........................UGUAAACAUCCUUGACUGGAAG.................................................................. 19 1 hsa-mir-30e_L08 J1_ES_untr ..........................UGUAAACAUCCUUGACUGGAAGC................................................................. 16 1 hsa-mir-30e_L09 ES_Dicer ..........................UGUAAACAUCCUUGACUGGAA................................................................... 12 1 hsa-mir-30e_L10 J1_ES_demeth ..........................UGUAAACAUCCUUGACUGGAA................................................................... 11 1 hsa-mir-30e_L11 J1_ES_untr ..........................UGUAAACAUCCUUGACUGGAA................................................................... 6 1 hsa-mir-30e_L12 ES_Dicer ..........................UGUAAACAUCCUUGACUGGA.................................................................... 4 1 hsa-mir-30e_L13 J1_ES_untr ...........................GUAAACAUCCUUGACUGGAAGCU................................................................ 3 1 hsa-mir-30e_L14 J1_ES_demeth ...........................GUAAACAUCCUUGACUGGAAGC................................................................. 2 1 hsa-mir-30e_L15 ES_Dicer ..........................UGUAAACAUCCUUGACUGGA.................................................................... 2 1 hsa-mir-30e_L16 J1_ES_demeth ..............................AACAUCCUUGACUGGAAGCU................................................................ 1 1 hsa-mir-30e_L17 ES_Dicer ............................UAAACAUCCUUGACUGGAAGC................................................................. 1 1 hsa-mir-30e_L18 ES_Dicer ............................UAAACAUCCUUGACUGGAAGCU................................................................ 1 1 hsa-mir-30e_L19 J1_ES_untr ...........................GUAAACAUCCUUGACUGGAAGCU................................................................ 1 1 hsa-mir-30e_L20 J1_ES_untr ...........................GUAAACAUCCUUGACUGGAAGCUGU.............................................................. 1 1 hsa-mir-30e_L21 J1_ES_demeth ...........................GUAAACAUCCUUGACUGGAAGC................................................................. 1 1 hsa-mir-30e_L22 J1_ES_demeth ............................UAAACAUCCUUGACUGGAAGCU................................................................ 1 1 hsa-mir-30e_L23 J1_ES_demeth ...........................GUAAACAUCCUUGACUGGAAG.................................................................. 1 1 hsa-mir-30e_L24 J1_ES_demeth ..........................UGUAAACAUCCUUGACUGG..................................................................... 1 1 hsa-mir-30e_L25 J1_ES_demeth ....................................................................CUUUCAGUCGGAUGUUUACAGC........................ 37 1 hsa-mir-30e_R01*_M J1_ES_untr ....................................................................CUUUCAGUCGGAUGUUUACAGC........................ 35 1 hsa-mir-30e_R02* J1_ES_demeth ....................................................................CUUUCAGUCGGAUGUUUACAG......................... 10 1 hsa-mir-30e_R03* J1_ES_demeth ....................................................................CUUUCAGUCGGAUGUUUACAG......................... 7 1 hsa-mir-30e_R04* J1_ES_untr ....................................................................CUUUCAGUCGGAUGUUUACAGC........................ 4 1 hsa-mir-30e_R05* ES_Dicer ....................................................................CUUUCAGUCGGAUGUUUACAG......................... 4 1 hsa-mir-30e_R06* ES_Dicer ....................................................................CUUUCAGUCGGAUGUUUAC........................... 2 1 hsa-mir-30e_R07* ES_Dicer ....................................................................CUUUCAGUCGGAUGUUUACA.......................... 2 1 hsa-mir-30e_R08* J1_ES_untr .....................................................................UUUCAGUCGGAUGUUUACAGC........................ 1 1 hsa-mir-30e_R09* J1_ES_demeth hsa-mir-31 chr9:21502094-21502204 - AACUUGGAACUGGAGAGGAGGCAAGAUGCUGGCAUAGCUGUUGAACUGGGAACCUGCUAUGCCAACAUAUUGCCAUCUUUCCUGUCUGACA ...(..((...((((((..(((((.(((.(((((((((.(((........)))..))))))))).))).)))))..))))))..))..).. (-40.80) ..................AGGCAAGAUGCUGGCAUAGCUGU.................................................. 56 1 hsa-mir-31_L01_M J1_ES_demeth ..................AGGCAAGAUGCUGGCAUAGCUGU.................................................. 31 1 hsa-mir-31_L02 J1_ES_untr ..................AGGCAAGAUGCUGGCAUAGCU.................................................... 12 1 hsa-mir-31_L03 J1_ES_demeth ..................AGGCAAGAUGCUGGCAUAGCUG................................................... 12 1 hsa-mir-31_L04 J1_ES_demeth ..................AGGCAAGAUGCUGGCAUAGCUGU.................................................. 4 1 hsa-mir-31_L05 ES_Dicer ..................AGGCAAGAUGCUGGCAUAGCUG................................................... 4 1 hsa-mir-31_L06 J1_ES_untr ..................AGGCAAGAUGCUGGCAUAGCU.................................................... 2 1 hsa-mir-31_L07 J1_ES_untr ..................AGGCAAGAUGCUGGCAUAGCUGUU................................................. 2 1 hsa-mir-31_L08 J1_ES_demeth ..................AGGCAAGAUGCUGGCAUAGCU.................................................... 1 1 hsa-mir-31_L09 ES_Dicer ..................AGGCAAGAUGCUGGCAUAGCUG................................................... 1 1 hsa-mir-31_L10 ES_Dicer ..................AGGCAAGAUGCUGGCAUAGC..................................................... 1 1 hsa-mir-31_L11 J1_ES_demeth ......................................................UGCUAUGCCAACAUAUUGCCAUC.............. 31 1 hsa-mir-31_R01*_M J1_ES_demeth ......................................................UGCUAUGCCAACAUAUUGCCAUC.............. 10 1 hsa-mir-31_R02* J1_ES_untr .......................................................GCUAUGCCAACAUAUUGCCAUC.............. 8 1 hsa-mir-31_R03* J1_ES_untr ......................................................UGCUAUGCCAACAUAUUGCCAU............... 6 1 hsa-mir-31_R04* J1_ES_demeth ......................................................UGCUAUGCCAACAUAUUGCCAUC.............. 5 1 hsa-mir-31_R05* ES_Dicer .......................................................GCUAUGCCAACAUAUUGCCAUC.............. 4 1 hsa-mir-31_R06* J1_ES_demeth ......................................................UGCUAUGCCAACAUAUUGCCAUCU............. 1 1 hsa-mir-31_R07* J1_ES_untr .......................................................GCUAUGCCAACAUAUUGCCAU............... 1 1 hsa-mir-31_R08* J1_ES_demeth ........................................................CUAUGCCAACAUAUUGCCAUCU............. 1 1 hsa-mir-31_R09* J1_ES_demeth ......................................................UGCUAUGCCAACAUAUUGCCAUCU............. 1 1 hsa-mir-31_R10* J1_ES_demeth hsa-mir-32 chr9:110848310-110848419 - UUGCUCUGGUGGAGAUAUUGCACAUUACUAAGUUGCAUGUUGUCACGGCCUCAAUGCAAUUUAGUGUGUGUGAUAUUUUCACAUGAGUG ..((((..((((((((((..(((((.(((((((((((((..((....))..).)))))))))))))))))..))))))))))..)))). (-42.30) ...............UAUUGCACAUUACUAAGUUG...................................................... 75 1 hsa-mir-32_L01_M ES_Dicer ...............UAUUGCACAUUACUAAGUUGCA.................................................... 45 1 hsa-mir-32_L02 ES_Dicer ...............UAUUGCACAUUACUAAGUUGC..................................................... 39 1 hsa-mir-32_L03 ES_Dicer ...............UAUUGCACAUUACUAAGUUGCAU................................................... 35 1 hsa-mir-32_L04 J1_ES_demeth ...............UAUUGCACAUUACUAAGUUGCA.................................................... 35 1 hsa-mir-32_L05 J1_ES_demeth ...............UAUUGCACAUUACUAAGUUGC..................................................... 22 1 hsa-mir-32_L06 J1_ES_demeth ...............UAUUGCACAUUACUAAGUUGCA.................................................... 21 1 hsa-mir-32_L07 J1_ES_untr ...............UAUUGCACAUUACUAAGUUGCAU................................................... 19 1 hsa-mir-32_L08 ES_Dicer ...............UAUUGCACAUUACUAAGUUGCAU................................................... 17 1 hsa-mir-32_L09 J1_ES_untr ...............UAUUGCACAUUACUAAGUUGC..................................................... 15 1 hsa-mir-32_L10 J1_ES_untr ...............UAUUGCACAUUACUAAGUUG...................................................... 4 1 hsa-mir-32_L11 J1_ES_demeth ...............UAUUGCACAUUACUAAGUU....................................................... 2 1 hsa-mir-32_L12 ES_Dicer ...............UAUUGCACAUUACUAAGUUG...................................................... 2 1 hsa-mir-32_L13 J1_ES_untr ..............AUAUUGCACAUUACUAAGUUGCA.................................................... 1 1 hsa-mir-32_L14 J1_ES_untr ........................................................CAAUUUAGUGUGUGUGAUAUU............ 7 1 hsa-mir-32_R01*_M J1_ES_demeth ........................................................CAAUUUAGUGUGUGUGAUAUU............ 3 1 hsa-mir-32_R02* ES_Dicer ........................................................CAAUUUAGUGUGUGUGAUAU............. 2 1 hsa-mir-32_R03* J1_ES_demeth ........................................................CAAUUUAGUGUGUGUGAUAU............. 1 1 hsa-mir-32_R04* ES_Dicer ......................................................UGCAAUUUAGUGUGUGUGAUAU............. 1 1 hsa-mir-32_R05* J1_ES_demeth .....................................UGUUGUCACGGCCUCAAUG................................. 1 1 hsa-mir-32_O01 J1_ES_untr hsa-mir-320a chr8:22158400-22158521 - AUCAGGCGGCGCUUCGCUCCCCUCCGCCUUCUCUUCCCGGUUCUUCCCGGAGUCGGGAAAAGCUGGGUUGAGAGGGCGAAAAAGGAUGAGGUGACUGGUCU (((((....(((((((.(((....(((((((((..(((((((.((((((....)))))).)))))))..))))))))).....)))))))))).))))).. (-53.90) .........................................................AAAAGCUGGGUUGAGAGGGCGA...................... 4 1 hsa-mir-320a_R01_M ES_Dicer .........................................................AAAAGCUGGGUUGAGAGGGCGAAA.................... 3 1 hsa-mir-320a_R02 J1_ES_demeth .........................................................AAAAGCUGGGUUGAGAGGGCGAA..................... 2 1 hsa-mir-320a_R03 ES_Dicer .........................................................AAAAGCUGGGUUGAGAGGGCGA...................... 2 1 hsa-mir-320a_R04 J1_ES_untr .........................................................AAAAGCUGGGUUGAGAGGGCGAA..................... 2 1 hsa-mir-320a_R05 J1_ES_demeth .........................................................AAAAGCUGGGUUGAGAGGGCGA...................... 2 1 hsa-mir-320a_R06 J1_ES_demeth ..........................................................AAAGCUGGGUUGAGAGGGCGAA..................... 2 1 hsa-mir-320a_R07 J1_ES_demeth ..........................................................AAAGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R08 ES_Dicer ..........................................................AAAGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R09 J1_ES_untr .........................................................AAAAGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R10 J1_ES_untr ...........................................................AAGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R11 J1_ES_demeth ...........................................................AAGCUGGGUUGAGAGGGCGAAA.................... 1 1 hsa-mir-320a_R12 J1_ES_demeth ..........................................................AAAGCUGGGUUGAGAGGGCGA...................... 1 1 hsa-mir-320a_R13 J1_ES_demeth hsa-mir-323 chr14:100561802-100561927 + GGCUGCUGCUUGGUACUUGGAGAGAGGUGGUCCGUGGCGCGUUCGCUUUAUUUAUGGCGCACAUUACACGGUCGACCUCUUUGCAGUAUCUAAUCCCGCCUUGCA (((........((((((.(.((((((((.(.(((((....((.((((........)))).))....))))).).)))))))).))))))).......)))..... (-41.66) ........................AGGUGGUCCGUGGCGCGUUCG............................................................ 3 1 hsa-mir-323_L01*_M J1_ES_untr .....CUGCUUGGUACUUGGAGAG................................................................................. 2 1 hsa-mir-323_L02* ES_Dicer ........................AGGUGGUCCGUGGCGCGUUCG............................................................ 1 1 hsa-mir-323_L03* ES_Dicer ..........................................................GCACAUUACACGGUCGACCUCU......................... 432 1 hsa-mir-323_R01_M J1_ES_untr ...........................................................CACAUUACACGGUCGACCUCU......................... 314 1 hsa-mir-323_R02 J1_ES_untr ...........................................................CACAUUACACGGUCGACCUCU......................... 231 1 hsa-mir-323_R03 J1_ES_demeth ..........................................................GCACAUUACACGGUCGACCUCU......................... 213 1 hsa-mir-323_R04 J1_ES_demeth ...........................................................CACAUUACACGGUCGACCUCU......................... 32 1 hsa-mir-323_R05 ES_Dicer ..........................................................GCACAUUACACGGUCGACCUC.......................... 10 1 hsa-mir-323_R06 J1_ES_untr ..........................................................GCACAUUACACGGUCGACCUC.......................... 9 1 hsa-mir-323_R07 J1_ES_demeth ..........................................................GCACAUUACACGGUCGACCUCU......................... 6 1 hsa-mir-323_R08 ES_Dicer ...........................................................CACAUUACACGGUCGACCUCUU........................ 6 1 hsa-mir-323_R09 J1_ES_untr .........................................................CGCACAUUACACGGUCGACCUCU......................... 6 1 hsa-mir-323_R10 J1_ES_untr ...........................................................CACAUUACACGGUCGACCUC.......................... 5 1 hsa-mir-323_R11 J1_ES_untr ..........................................................GCACAUUACACGGUCGACCUCUU........................ 5 1 hsa-mir-323_R12 J1_ES_untr ...........................................................CACAUUACACGGUCGACCUCUU........................ 5 1 hsa-mir-323_R13 J1_ES_demeth ...........................................................CACAUUACACGGUCGACCUC.......................... 4 1 hsa-mir-323_R14 J1_ES_demeth ..........................................................GCACAUUACACGGUCGACCUC.......................... 3 1 hsa-mir-323_R15 ES_Dicer ..........................................................GCACAUUACACGGUCGACCUCUU........................ 2 1 hsa-mir-323_R16 J1_ES_demeth ...........................................................CACAUUACACGGUCGACCUCUU........................ 1 1 hsa-mir-323_R17 ES_Dicer ............................................................ACAUUACACGGUCGACCUCU......................... 1 1 hsa-mir-323_R18 J1_ES_untr ...........................................................CACAUUACACGGUCGACCU........................... 1 1 hsa-mir-323_R19 J1_ES_demeth ..........................................................GCACAUUACACGGUCGACCU........................... 1 1 hsa-mir-323_R20 J1_ES_demeth hsa-mir-324 chr17:7067320-7067442 - AGAAGCUGAGCUGACUAUGCCUCCCCGCAUCCCCUAGGGCAUUGGUGUAAAGCUGGAGACCCACUGCCCCAGGUGCUGCUGGGGGUUGUAGUCUGACCCGAC ............((((((..(((((.(((.(.(((.(((((.(((.((..........))))).))))).))).).))).)))))..))))))......... (-39.80) .........................CGCAUCCCCUAGGGCAUUGGUGU...................................................... 9 1 hsa-mir-324_L01_M J1_ES_untr .........................CGCAUCCCCUAGGGCAUUGGUGU...................................................... 5 1 hsa-mir-324_L02 J1_ES_demeth .........................CGCAUCCCCUAGGGCAUUGGU........................................................ 2 1 hsa-mir-324_L03 J1_ES_demeth .........................CGCAUCCCCUAGGGCAUUGGUGUA..................................................... 2 1 hsa-mir-324_L04 J1_ES_demeth .........................CGCAUCCCCUAGGGCAUUGG......................................................... 1 1 hsa-mir-324_L05 ES_Dicer .........................CGCAUCCCCUAGGGCAUUGGU........................................................ 1 1 hsa-mir-324_L06 ES_Dicer .........................CGCAUCCCCUAGGGCAUUGGUGUAAA................................................... 1 1 hsa-mir-324_L07 J1_ES_untr .........................CGCAUCCCCUAGGGCAUUGG......................................................... 1 1 hsa-mir-324_L08 J1_ES_demeth ............................................................CCACUGCCCCAGGUGCUGCUGG.................... 1 1 hsa-mir-324_R01*_M ES_Dicer ..............................................................ACUGCCCCAGGUGCUGCUGG.................... 1 1 hsa-mir-324_R02* ES_Dicer ............................................................CCACUGCCCCAGGUGCUGCUG..................... 1 1 hsa-mir-324_R03* ES_Dicer .............................................................CACUGCCCCAGGUGCUGCUG..................... 1 1 hsa-mir-324_R04* J1_ES_untr hsa-mir-326 chr11:74723764-74723898 - CUUCCGGAGCCUCAUCUGUCUGUUGGGCUGGAGGCAGGGCCUUUGUGAAGGCGGGUGGUGCUCAGAUCGCCUCUGGGCCCUUCCUCCAGCCCCGAGGCGGAUUCACCAUGAGGC ........(((((((((((((...((((((((((.(((((((....((.(((((.((.....))..))))))).))))))).))))))))))..))))))).......)))))) (-62.71) ........GCCUCAUCUGUCUGUUGG........................................................................................ 1 1 hsa-mir-326_L01_M ES_Dicer hsa-mir-328 chr16:65793705-65793819 - UCUCAGAGCCUGGAGUGGGGGGGCAGGAGGGGCUCAGGGAGAAAGUGCAUACAGCCCCUGGCCCUCUCUGCCCUUCCGUCCCCUGCUCUUGGCC .((.(((((..((..(((((((((((..(((((.(((((.(...((....))..)))))))))))..)))))))))))..))..))))).)).. (-55.00) .........................................................CUGGCCCUCUCUGCCCUUCCGU............... 3 1 hsa-mir-328_R01_M J1_ES_untr .........................................................CUGGCCCUCUCUGCCCUUCC................. 1 1 hsa-mir-328_R02 ES_Dicer .........................................................CUGGCCCUCUCUGCCCUUCCGU............... 1 1 hsa-mir-328_R03 J1_ES_demeth .........................................................CUGGCCCUCUCUGCCCUUCCG................ 1 1 hsa-mir-328_R04 J1_ES_demeth hsa-mir-330 chr19:50834072-50834205 - GCUGUGUGAUCUUUGGCGAUCACUGCCUCUCUGGGCCUGUGUCUUAGGCUCUGCAAGAUCAACCGAGCAAAGCACACGGCCUGCAGAGAGGCAGCGCUCUGCCCCUUACUCGGCC ((((.((((.....(((((.(.(((((((((((((((((((.(((..((((.............)))).))))))).))))..))))))))))).).)).)))..)))).)))). (-53.82) ...........................UCUCUGGGCCUGUGUCUUAG.................................................................... 1 1 hsa-mir-330_L01_M J1_ES_demeth hsa-mir-331 chr12:94226307-94226440 + ACUCCCAAGGAGUUUGGUUUUGUUUGGGUUUGUUCUAGGUAUGGUCCCAGGGAUCCCAGAUCAAACCAGGCCCCUGGGCCUAUCCUAGAACCAACCUAAGCUCGCGCAUCAUU (((((...))))).((((...(((((((((.((((((((.((((.(((((((..(.............)..))))))).)))))))))))).)))))))))..)).))..... (-48.22) ..................................CUAGGUAUGGUCCCAGGGAUC.......................................................... 1 1 hsa-mir-331_L01*_M J1_ES_demeth .....................................................................GCCCCUGGGCCUAUCCUAGAA....................... 5 1 hsa-mir-331_R01_M J1_ES_demeth .....................................................................GCCCCUGGGCCUAUCCUAGA........................ 1 1 hsa-mir-331_R02 ES_Dicer .....................................................................GCCCCUGGGCCUAUCCUAGAA....................... 1 1 hsa-mir-331_R03 ES_Dicer .....................................................................GCCCCUGGGCCUAUCCUAGA........................ 1 1 hsa-mir-331_R04 J1_ES_demeth hsa-mir-335 chr7:129923168-129923301 + GGAAAUGAUUUGUUUUGAGCGGGGGUCAAGAGCAAUAACGAAAAAUGUUUGUCAUAAACCGUUUUUCAUUAUUGCUCCUGACCUCCUCUCAUUUGCUAUAUUCAAUUAAGUAAGU .....(((...((..((((.((((((((.(((((((((.((((((((.((......)).)))))))).))))))))).)))))))).))))...)).....)))........... (-42.80) .........................UCAAGAGCAAUAACGAAAAAUG.................................................................... 83 1 hsa-mir-335_L01_M J1_ES_demeth .........................UCAAGAGCAAUAACGAAAAAUGU................................................................... 56 1 hsa-mir-335_L02 J1_ES_demeth .........................UCAAGAGCAAUAACGAAAAAUGU................................................................... 11 1 hsa-mir-335_L03 J1_ES_untr .........................UCAAGAGCAAUAACGAAAAAUG.................................................................... 10 1 hsa-mir-335_L04 J1_ES_untr .........................UCAAGAGCAAUAACGAAAAAU..................................................................... 7 1 hsa-mir-335_L05 J1_ES_demeth .........................UCAAGAGCAAUAACGAAAAAUGUU.................................................................. 5 1 hsa-mir-335_L06 J1_ES_demeth .........................UCAAGAGCAAUAACGAAAAAUG.................................................................... 4 1 hsa-mir-335_L07 ES_Dicer .........................UCAAGAGCAAUAACGAAAAAUGU................................................................... 3 1 hsa-mir-335_L08 ES_Dicer ...........................AAGAGCAAUAACGAAAAAUGUU.................................................................. 2 1 hsa-mir-335_L09 J1_ES_demeth .........................UCAAGAGCAAUAACGAAAAAU..................................................................... 1 1 hsa-mir-335_L10 ES_Dicer ............................AGAGCAAUAACGAAAAAUGUUU................................................................. 1 1 hsa-mir-335_L11 J1_ES_untr .........................UCAAGAGCAAUAACGAAAAAUGUU.................................................................. 1 1 hsa-mir-335_L12 J1_ES_untr .............................................................UUUUUCAUUAUUGCUCCUGACC................................ 44 1 hsa-mir-335_R01*_M J1_ES_demeth ..............................................................UUUUCAUUAUUGCUCCUGACC................................ 25 1 hsa-mir-335_R02* J1_ES_demeth .............................................................UUUUUCAUUAUUGCUCCUGACC................................ 17 1 hsa-mir-335_R03* J1_ES_untr .............................................................UUUUUCAUUAUUGCUCCUGAC................................. 16 1 hsa-mir-335_R04* J1_ES_demeth ............................................................GUUUUUCAUUAUUGCUCCUGACC................................ 13 1 hsa-mir-335_R05* J1_ES_demeth .............................................................UUUUUCAUUAUUGCUCCUGA.................................. 7 1 hsa-mir-335_R06* J1_ES_demeth ..............................................................UUUUCAUUAUUGCUCCUGAC................................. 6 1 hsa-mir-335_R07* J1_ES_demeth ..............................................................UUUUCAUUAUUGCUCCUGACC................................ 4 1 hsa-mir-335_R08* J1_ES_untr ............................................................GUUUUUCAUUAUUGCUCCUGACC................................ 4 1 hsa-mir-335_R09* J1_ES_untr .............................................................UUUUUCAUUAUUGCUCCUGAC................................. 4 1 hsa-mir-335_R10* J1_ES_untr ............................................................GUUUUUCAUUAUUGCUCCUGAC................................. 3 1 hsa-mir-335_R11* J1_ES_demeth .............................................................UUUUUCAUUAUUGCUCCUGAC................................. 2 1 hsa-mir-335_R12* ES_Dicer ..............................................................UUUUCAUUAUUGCUCCUGA.................................. 2 1 hsa-mir-335_R13* J1_ES_demeth ............................................................GUUUUUCAUUAUUGCUCCUGACC................................ 1 1 hsa-mir-335_R14* ES_Dicer .............................................................UUUUUCAUUAUUGCUCCUGACC................................ 1 1 hsa-mir-335_R15* ES_Dicer ............................................................GUUUUUCAUUAUUGCUCCUGACCU............................... 1 1 hsa-mir-335_R16* J1_ES_untr ............................................................GUUUUUCAUUAUUGCUCCUGAC................................. 1 1 hsa-mir-335_R17* J1_ES_untr ............................................................GUUUUUCAUUAUUGCUCCUGACCU............................... 1 1 hsa-mir-335_R18* J1_ES_demeth ..............................................................UUUUCAUUAUUGCUCCUG................................... 1 1 hsa-mir-335_R19* J1_ES_demeth .........................................................ACCGUUUUUCAUUAUUGCUCCU.................................... 1 1 hsa-mir-335_O01 J1_ES_demeth hsa-mir-337 chr14:100410563-100410695 + UUGCGGCCCGUAGUCAGUAGUUGGGGGGUGGGAACGGCUUCAUACAGGAGUUGAUGCACAGUUAUCCAGCUCCUAUAUGAUGCCUUUCUUCAUCCCCUUCAACCACGCGCAG .((((....(....).((.(((((((((((((((.(((.(((((.(((((((((((......))).)))))))).))))).))).))).))))))))..)))).)).)))). (-46.50) ...................................................................AGCUCCUAUAUGAUGCCUUUCUU...................... 5 1 hsa-mir-337_R01_M J1_ES_demeth ...................................................................AGCUCCUAUAUGAUGCCUUUCU....................... 2 1 hsa-mir-337_R02 J1_ES_untr .....................................................................CUCCUAUAUGAUGCCUUUCUU...................... 1 1 hsa-mir-337_R03 J1_ES_demeth ...................................................................AGCUCCUAUAUGAUGCCUUUCU....................... 1 1 hsa-mir-337_R04 J1_ES_demeth hsa-mir-338 chr17:76714258-76714364 - ACGGCUGUCCUCUCCAACAAUAUCCUGGUGCUGAGUGAUGACUCAGGCGACUCCAGCAUCAGUGAUUUUGUUGAAGAGGGCAGCUG .((((((((((((.((((((.(((((((((((((((.............))).))))))))).))).)))))).)))))))))))) (-47.72) ...............AACAAUAUCCUGGUGCUGAGU.................................................. 1 1 hsa-mir-338_L01*_M J1_ES_untr ...................................................UCCAGCAUCAGUGAUUUUGUUGA............ 9 1 hsa-mir-338_R01_M J1_ES_untr ...................................................UCCAGCAUCAGUGAUUUUGUUGA............ 2 1 hsa-mir-338_R02 J1_ES_demeth ...................................................UCCAGCAUCAGUGAUUUUGUUG............. 1 1 hsa-mir-338_R03 J1_ES_untr hsa-mir-339 chr7:1029075-1029208 - CUCCGCAGGGGCGGGGCGGCCGCUCUCCCUGUCCUCCAGGAGCUCACGUGUGCCUGCCUGUGAGCGCCUCGACGACAGAGCCGGCGCCUGCCCCAGUGUCUGCGCCGGGACCAUG (((((((((.(((((((((.((((..(.(((((.((.(((.(((((((.((....)).))))))).))).)).))))).)..)))).))))))).)).))))))..)))...... (-61.60) .........................UCCCUGUCCUCCAGGAGCUCA..................................................................... 23 1 hsa-mir-339_L01_M J1_ES_untr .........................UCCCUGUCCUCCAGGAGCUCA..................................................................... 23 1 hsa-mir-339_L02 J1_ES_demeth .........................UCCCUGUCCUCCAGGAGCUC...................................................................... 22 1 hsa-mir-339_L03 J1_ES_demeth .........................UCCCUGUCCUCCAGGAGCUCAC.................................................................... 7 1 hsa-mir-339_L04 J1_ES_demeth .........................UCCCUGUCCUCCAGGAGCUCACG................................................................... 6 1 hsa-mir-339_L05 J1_ES_untr .........................UCCCUGUCCUCCAGGAGCUC...................................................................... 5 1 hsa-mir-339_L06 J1_ES_untr .........................UCCCUGUCCUCCAGGAGCUCA..................................................................... 4 1 hsa-mir-339_L07 ES_Dicer .........................UCCCUGUCCUCCAGGAGCUCAC.................................................................... 4 1 hsa-mir-339_L08 J1_ES_untr .........................UCCCUGUCCUCCAGGAGCUCACG................................................................... 4 1 hsa-mir-339_L09 J1_ES_demeth .........................UCCCUGUCCUCCAGGAGCUCACG................................................................... 2 1 hsa-mir-339_L10 ES_Dicer .........................UCCCUGUCCUCCAGGAGCU....................................................................... 2 1 hsa-mir-339_L11 J1_ES_demeth .........................UCCCUGUCCUCCAGGAGCUCAC.................................................................... 1 1 hsa-mir-339_L12 ES_Dicer .........................UCCCUGUCCUCCAGGAGCUC...................................................................... 1 1 hsa-mir-339_L13 ES_Dicer .........................UCCCUGUCCUCCAGGAGCUCACGU.................................................................. 1 1 hsa-mir-339_L14 J1_ES_untr .........................UCCCUGUCCUCCAGGAGC........................................................................ 1 1 hsa-mir-339_L15 J1_ES_demeth hsa-mir-33a chr22:40626874-40626982 + GGCGGGCAGCUGUGGUGCAUUGUAGUUGCAUUGCAUGUUCUGGUGGUACCCAUGCAAUGUUUCCACAGUGCAUCACAGAGGCCUGCCU (((((((..((((((((((((((.(..((((((((((....((.....))))))))))))..).))))))))))))))..))))))). (-56.10) ..............GUGCAUUGUAGUUGCAUUGC...................................................... 104 1 hsa-mir-33a_L01_M J1_ES_demeth ..............GUGCAUUGUAGUUGCAUUGC...................................................... 73 1 hsa-mir-33a_L02 ES_Dicer ..............GUGCAUUGUAGUUGCAUUGC...................................................... 38 1 hsa-mir-33a_L03 J1_ES_untr ..............GUGCAUUGUAGUUGCAUUGCA..................................................... 9 1 hsa-mir-33a_L04 ES_Dicer ..............GUGCAUUGUAGUUGCAUUGCA..................................................... 7 1 hsa-mir-33a_L05 J1_ES_untr ..............GUGCAUUGUAGUUGCAUUGCA..................................................... 7 1 hsa-mir-33a_L06 J1_ES_demeth ...............UGCAUUGUAGUUGCAUUGCA..................................................... 3 1 hsa-mir-33a_L07 ES_Dicer ..............GUGCAUUGUAGUUGCAUU........................................................ 2 1 hsa-mir-33a_L08 ES_Dicer ...............UGCAUUGUAGUUGCAUUGC...................................................... 1 1 hsa-mir-33a_L09 ES_Dicer .............GGUGCAUUGUAGUUGCAUUGC...................................................... 1 1 hsa-mir-33a_L10 J1_ES_demeth ...............UGCAUUGUAGUUGCAUUG....................................................... 1 1 hsa-mir-33a_L11 J1_ES_demeth ..............GUGCAUUGUAGUUGCAUUG....................................................... 1 1 hsa-mir-33a_L12 J1_ES_demeth ......................................................CAAUGUUUCCACAGUGCAUCA............. 14 1 hsa-mir-33a_R01*_M J1_ES_untr ......................................................CAAUGUUUCCACAGUGCAUCA............. 9 1 hsa-mir-33a_R02* J1_ES_demeth ......................................................CAAUGUUUCCACAGUGCAUCA............. 2 1 hsa-mir-33a_R03* ES_Dicer ......................................................CAAUGUUUCCACAGUGCAUC.............. 1 1 hsa-mir-33a_R04* ES_Dicer hsa-mir-340 chr5:179374889-179375023 - UUCUAAAACCGUUUGUACCUGGUGUGAUUAUAAAGCAAUGAGACUGAUUGUCAUAUGUCGUUUGUGGGAUCCGUCUCAGUUACUUUAUAGCCAUACCUGGUAUCUUAUACCACAGA ..............(((((.((((((..(((((((...((((((.((((.(((((.......))))))))).))))))....)))))))..)))))).)))))............. (-36.00) ...........................UUAUAAAGCAAUGAGACUGAUU................................................................... 37 1 hsa-mir-340_L01_M J1_ES_demeth ...........................UUAUAAAGCAAUGAGACUGAUU................................................................... 28 1 hsa-mir-340_L02 J1_ES_untr ...........................UUAUAAAGCAAUGAGACUGAU.................................................................... 10 1 hsa-mir-340_L03 J1_ES_demeth ...........................UUAUAAAGCAAUGAGACUGAU.................................................................... 4 1 hsa-mir-340_L04 J1_ES_untr ...........................UUAUAAAGCAAUGAGACUGAUU................................................................... 2 1 hsa-mir-340_L05 ES_Dicer ...........................UUAUAAAGCAAUGAGACUGAU.................................................................... 2 1 hsa-mir-340_L06 ES_Dicer ...........................UUAUAAAGCAAUGAGACUGA..................................................................... 1 1 hsa-mir-340_L07 J1_ES_demeth ............................UAUAAAGCAAUGAGACUGAUU................................................................... 1 1 hsa-mir-340_L08 J1_ES_demeth .....................................................................UCCGUCUCAGUUACUUUAUAGCC........................ 12 1 hsa-mir-340_R01*_M J1_ES_demeth .....................................................................UCCGUCUCAGUUACUUUAUAGCC........................ 9 1 hsa-mir-340_R02* J1_ES_untr .....................................................................UCCGUCUCAGUUACUUUAUAGC......................... 8 1 hsa-mir-340_R03* J1_ES_demeth .....................................................................UCCGUCUCAGUUACUUUAUAG.......................... 2 1 hsa-mir-340_R04* J1_ES_untr .....................................................................UCCGUCUCAGUUACUUUAUAGCC........................ 1 1 hsa-mir-340_R05* ES_Dicer ......................................................................CCGUCUCAGUUACUUUAUAGCC........................ 1 1 hsa-mir-340_R06* J1_ES_untr .....................................................................UCCGUCUCAGUUACUUUAUAGCCAU...................... 1 1 hsa-mir-340_R07* J1_ES_untr .....................................................................UCCGUCUCAGUUACUUUAUAGCCA....................... 1 1 hsa-mir-340_R08* J1_ES_untr .......................................................................CGUCUCAGUUACUUUAUAGCC........................ 1 1 hsa-mir-340_R09* J1_ES_demeth ....................................................................AUCCGUCUCAGUUACUUUAUAGCC........................ 1 1 hsa-mir-340_R10* J1_ES_demeth hsa-mir-342 chr14:99645725-99645863 + CCAACCUGUGAAACUGGGCUCAAGGUGAGGGGUGCUAUCUGUGAUUGAGGGACAUGGUUAAUGGAAUUGUCUCACACAGAAAUCGCACCCGUCACCUUGGCCUACUUAUCACCACCCC .......((((((.(((((.((((((((.((((((..((((((.....((((((...((....))..)))))).))))))....)))))).))))))))))))).)).))))...... (-51.40) .....................................................................UCUCACACAGAAAUCGCACCCGUC......................... 50 1 hsa-mir-342_R01_M J1_ES_demeth .....................................................................UCUCACACAGAAAUCGCACCCGUC......................... 32 1 hsa-mir-342_R02 J1_ES_untr .....................................................................UCUCACACAGAAAUCGCACCCGU.......................... 25 1 hsa-mir-342_R03 J1_ES_demeth .....................................................................UCUCACACAGAAAUCGCACCCGU.......................... 20 1 hsa-mir-342_R04 J1_ES_untr .....................................................................UCUCACACAGAAAUCGCACCCGUCA........................ 14 1 hsa-mir-342_R05 J1_ES_demeth .......................................................................UCACACAGAAAUCGCACCCGUCA........................ 12 1 hsa-mir-342_R06 J1_ES_demeth .....................................................................UCUCACACAGAAAUCGCACCCGUCA........................ 11 1 hsa-mir-342_R07 J1_ES_untr .......................................................................UCACACAGAAAUCGCACCCGUCA........................ 7 1 hsa-mir-342_R08 J1_ES_untr .....................................................................UCUCACACAGAAAUCGCACCCGU.......................... 3 1 hsa-mir-342_R09 ES_Dicer .....................................................................UCUCACACAGAAAUCGCACCC............................ 2 1 hsa-mir-342_R10 J1_ES_untr .....................................................................UCUCACACAGAAAUCGCACC............................. 1 1 hsa-mir-342_R11 ES_Dicer .....................................................................UCUCACACAGAAAUCGCACCCGUC......................... 1 1 hsa-mir-342_R12 ES_Dicer .......................................................................UCACACAGAAAUCGCACCCGU.......................... 1 1 hsa-mir-342_R13 J1_ES_untr ....................................................................GUCUCACACAGAAAUCGCACCCGUC......................... 1 1 hsa-mir-342_R14 J1_ES_demeth .......................................................................UCACACAGAAAUCGCACCCGU.......................... 1 1 hsa-mir-342_R15 J1_ES_demeth hsa-mir-34a chr1:9134294-9134443 - GCCGUGGACCGGCCAGCUGUGAGUGUUUCUUUGGCAGUGUCUUAGCUGGUUGUUGUGAGCAAUAGUAAGGAAGCAAUCAGCAAGUAUACUGCCCUAGAAGUGCUGCACGUUGUGGGGCCCAAGAGGGAAGAUG .((.(((.((.((.(((.(((((..(((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..)))))..)).)))))))).))..)))...))....... (-55.70) ...............................UGGCAGUGUCUUAGCUGGUUGU................................................................................ 224 1 hsa-mir-34a_L01_M J1_ES_untr ...............................UGGCAGUGUCUUAGCUGGUUGU................................................................................ 201 1 hsa-mir-34a_L02 J1_ES_demeth ...............................UGGCAGUGUCUUAGCUGGUUGUU............................................................................... 200 1 hsa-mir-34a_L03 J1_ES_untr ...............................UGGCAGUGUCUUAGCUGGUUGUU............................................................................... 194 1 hsa-mir-34a_L04 J1_ES_demeth ...............................UGGCAGUGUCUUAGCUGGUUGU................................................................................ 90 1 hsa-mir-34a_L05 ES_Dicer ...............................UGGCAGUGUCUUAGCUGGUUGUU............................................................................... 39 1 hsa-mir-34a_L06 ES_Dicer ...............................UGGCAGUGUCUUAGCUGGUUG................................................................................. 7 1 hsa-mir-34a_L07 J1_ES_demeth ...............................UGGCAGUGUCUUAGCUGGUUG................................................................................. 5 1 hsa-mir-34a_L08 ES_Dicer ...............................UGGCAGUGUCUUAGCUGGUUG................................................................................. 4 1 hsa-mir-34a_L09 J1_ES_untr ...............................UGGCAGUGUCUUAGCUGGUU.................................................................................. 3 1 hsa-mir-34a_L10 J1_ES_demeth ...............................UGGCAGUGUCUUAGCUGGU................................................................................... 1 1 hsa-mir-34a_L11 ES_Dicer ...............................UGGCAGUGUCUUAGCUGGUU.................................................................................. 1 1 hsa-mir-34a_L12 ES_Dicer ................................GGCAGUGUCUUAGCUGGUUGU................................................................................ 1 1 hsa-mir-34a_L13 J1_ES_untr ..................................CAGUGUCUUAGCUGGUUGUU............................................................................... 1 1 hsa-mir-34a_L14 J1_ES_untr ..................................CAGUGUCUUAGCUGGUUGU................................................................................ 1 1 hsa-mir-34a_L15 J1_ES_untr ...............................UGGCAGUGUCUUAGCUGGUUGUUGU............................................................................. 1 1 hsa-mir-34a_L16 ES_Dicer-DEL ..........................................................................AAUCAGCAAGUAUACUGCCCUA..................................... 18 1 hsa-mir-34a_R01*_M J1_ES_demeth ..........................................................................AAUCAGCAAGUAUACUGCCCUA..................................... 11 1 hsa-mir-34a_R02* J1_ES_untr ..........................................................................AAUCAGCAAGUAUACUGCCCU...................................... 6 1 hsa-mir-34a_R03* J1_ES_demeth .........................................................................CAAUCAGCAAGUAUACUGCCCUA..................................... 6 1 hsa-mir-34a_R04* J1_ES_demeth .........................................................................CAAUCAGCAAGUAUACUGCCCUA..................................... 5 1 hsa-mir-34a_R05* J1_ES_untr ..........................................................................AAUCAGCAAGUAUACUGCCCUA..................................... 4 1 hsa-mir-34a_R06* ES_Dicer ..........................................................................AAUCAGCAAGUAUACUGCCCU...................................... 3 1 hsa-mir-34a_R07* J1_ES_untr .........................................................................CAAUCAGCAAGUAUACUGCCCUA..................................... 1 1 hsa-mir-34a_R08* ES_Dicer .........................................................................CAAUCAGCAAGUAUACUGCCCU...................................... 1 1 hsa-mir-34a_R09* J1_ES_demeth .........................................................................CAAUCAGCAAGUAUACUGCCCU...................................... 1 1 hsa-mir-34a_R10* J1_ES_untr hsa-mir-34b chr11:110888853-110888976 + CGGGUGCCCGGUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCACAGCAUCACCG ..(((((...(((((..((((...(((((((...((((.((((((((((.....)).))))))))))))...)))))))....))))..))))).))))).... (-42.30) ............................................................AAUCACUAACUCCACUGCCAUC...................... 10 1 hsa-mir-34b_R01_M J1_ES_demeth .............................................................AUCACUAACUCCACUGCCAUCA..................... 8 1 hsa-mir-34b_R02 J1_ES_demeth ............................................................AAUCACUAACUCCACUGCCAUC...................... 4 1 hsa-mir-34b_R03 J1_ES_untr .............................................................AUCACUAACUCCACUGCCAUC...................... 2 1 hsa-mir-34b_R04 ES_Dicer .............................................................AUCACUAACUCCACUGCCAUC...................... 2 1 hsa-mir-34b_R05 J1_ES_untr ............................................................AAUCACUAACUCCACUGCCAUCA..................... 2 1 hsa-mir-34b_R06 J1_ES_demeth ............................................................AAUCACUAACUCCACUGCCAU....................... 2 1 hsa-mir-34b_R07 J1_ES_demeth ............................................................AAUCACUAACUCCACUGCCAUCAA.................... 1 1 hsa-mir-34b_R08 J1_ES_untr ............................................................AAUCACUAACUCCACUGCCAU....................... 1 1 hsa-mir-34b_R09 J1_ES_untr ............................................................AAUCACUAACUCCACUGCCAUCA..................... 1 1 hsa-mir-34b_R10 J1_ES_untr hsa-mir-34c chr11:110889354-110889470 + UUUUUUCUAUGAGUCUAGUUACUAGGCAGUGUAGUUAGCUGAUUGCUAAUAGUACCAAUCACUAACCACACGGCCAGGUAAAAAGAUUUGGGAAUUCG ...(((((..((((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..))))))))))).... (-34.10) .......................AGGCAGUGUAGUUAGCUGAUUGC.................................................... 51 1 hsa-mir-34c_L01_M J1_ES_demeth .......................AGGCAGUGUAGUUAGCUGAUUGC.................................................... 18 1 hsa-mir-34c_L02 J1_ES_untr ..........................CAGUGUAGUUAGCUGAUUG..................................................... 1 1 hsa-mir-34c_L03 ES_Dicer .......................AGGCAGUGUAGUUAGCUGAUUGC.................................................... 1 1 hsa-mir-34c_L04 ES_Dicer .......................AGGCAGUGUAGUUAGCUGAUUG..................................................... 1 1 hsa-mir-34c_L05 ES_Dicer .......................AGGCAGUGUAGUUAGCUGAUUG..................................................... 1 1 hsa-mir-34c_L06 J1_ES_demeth .......................AGGCAGUGUAGUUAGCUGAUU...................................................... 1 1 hsa-mir-34c_L07 J1_ES_demeth .......................AGGCAGUGUAGUUAGCUGAUUGCU................................................... 1 1 hsa-mir-34c_L08 J1_ES_demeth hsa-mir-361 chrX:85045277-85045388 - CUGGGAUUUGGGAGCUUAUCAGAAUCUCCAGGGGUACUUUAUAAUUUCAAAAAGUCCCCCAGGUGUGAUUCUGAUUUGCUUCCUUUUCCUC ..((((...((((((..(((((((((.((.((((.(((((..........))))).)))).))...)))))))))..))))))...)))). (-41.90) ...............UUAUCAGAAUCUCCAGGGGUAC...................................................... 85 1 hsa-mir-361_L01_M J1_ES_untr ...............UUAUCAGAAUCUCCAGGGGUAC...................................................... 19 1 hsa-mir-361_L02 J1_ES_demeth ...............UUAUCAGAAUCUCCAGGGGUA....................................................... 9 1 hsa-mir-361_L03 J1_ES_untr ...............UUAUCAGAAUCUCCAGGGGUACU..................................................... 6 1 hsa-mir-361_L04 J1_ES_demeth ...............UUAUCAGAAUCUCCAGGGG......................................................... 1 1 hsa-mir-361_L05 J1_ES_demeth ...............UUAUCAGAAUCUCCAGGGGU........................................................ 1 1 hsa-mir-361_L06 J1_ES_demeth ...............UUAUCAGAAUCUCCAGGGGUA....................................................... 1 1 hsa-mir-361_L07 J1_ES_demeth hsa-mir-362 chrX:49660292-49660396 + GCUCCCCCUCUUGAAUCCUUGGAACCUAGGUGUGAGUGCUAUUUCAGUGCAACACACCUAUUCAAGGAUUCAAAGAGGCUGAGC ((((..(((((((((((((((((...((((((((.(..((.....))..)..))))))))))))))))))).))))))..)))) (-44.10) .............AAUCCUUGGAACCUAGGUGUGA................................................. 8 1 hsa-mir-362_L01_M ES_Dicer .............AAUCCUUGGAACCUAGGUGUGA................................................. 8 1 hsa-mir-362_L02 J1_ES_demeth .............AAUCCUUGGAACCUAGGUGUGA................................................. 4 1 hsa-mir-362_L03 J1_ES_untr .............AAUCCUUGGAACCUAGGUGUG.................................................. 4 1 hsa-mir-362_L04 J1_ES_demeth .............AAUCCUUGGAACCUAGGUGU................................................... 2 1 hsa-mir-362_L05 ES_Dicer .............AAUCCUUGGAACCUAGGUGUG.................................................. 1 1 hsa-mir-362_L06 ES_Dicer .............AAUCCUUGGAACCUAGGUGU................................................... 1 1 hsa-mir-362_L07 J1_ES_demeth hsa-mir-363 chrX:133131054-133131168 - UCUGUUUUGCUGUUGUCGGGUGGAUCACGAUGCAAUUUUGAUGAGUAUCAUAGGAGAAAAAUUGCACGGUAUCCAUCUGUAAACCGCAGGACCU ...(((((((.(((..(((((((((..((.(((((((((.(((.....)))......)))))))))))..)))))))))..))).))))))).. (-35.10) ............................................................AUUGCACGGUAUCCAUCUGUAA............ 181 1 hsa-mir-363_R01_M J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGUA............. 149 1 hsa-mir-363_R02 J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGUAA............ 90 1 hsa-mir-363_R03 J1_ES_untr ............................................................AUUGCACGGUAUCCAUCUGUA............. 80 1 hsa-mir-363_R04 J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGU.............. 66 1 hsa-mir-363_R05 J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGUA............. 36 1 hsa-mir-363_R06 J1_ES_demeth ............................................................AUUGCACGGUAUCCAUCUGUAA............ 36 1 hsa-mir-363_R07 J1_ES_demeth ...........................................................AAUUGCACGGUAUCCAUCUGUAA............ 29 1 hsa-mir-363_R08 J1_ES_demeth ............................................................AUUGCACGGUAUCCAUCUGUA............. 21 1 hsa-mir-363_R09 J1_ES_demeth ............................................................AUUGCACGGUAUCCAUCUGU.............. 17 1 hsa-mir-363_R10 J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGU.............. 17 1 hsa-mir-363_R11 J1_ES_demeth ...........................................................AAUUGCACGGUAUCCAUCUGUA............. 16 1 hsa-mir-363_R12 ES_Dicer ............................................................AUUGCACGGUAUCCAUCUGU.............. 12 1 hsa-mir-363_R13 J1_ES_demeth ............................................................AUUGCACGGUAUCCAUCUGUAAA........... 11 1 hsa-mir-363_R14 J1_ES_untr ............................................................AUUGCACGGUAUCCAUCUGUA............. 5 1 hsa-mir-363_R15 ES_Dicer .............................................................UUGCACGGUAUCCAUCUGUAAA........... 4 1 hsa-mir-363_R16 J1_ES_untr ..........................................................AAAUUGCACGGUAUCCAUCUGU.............. 3 1 hsa-mir-363_R17 J1_ES_untr .............................................................UUGCACGGUAUCCAUCUGUAA............ 2 1 hsa-mir-363_R18 J1_ES_untr ............................................................AUUGCACGGUAUCCAUCUGU.............. 1 1 hsa-mir-363_R19 ES_Dicer ...........................................................AAUUGCACGGUAUCCAUCUG............... 1 1 hsa-mir-363_R20 ES_Dicer ............................................................AUUGCACGGUAUCCAUCUG............... 1 1 hsa-mir-363_R21 ES_Dicer ..........................................................AAAUUGCACGGUAUCCAUCUGUAA............ 1 1 hsa-mir-363_R22 J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGUAAA........... 1 1 hsa-mir-363_R23 J1_ES_untr ...........................................................AAUUGCACGGUAUCCAUCUGUAAA........... 1 1 hsa-mir-363_R24 J1_ES_demeth ..........................................................AAAUUGCACGGUAUCCAUCUGU.............. 1 1 hsa-mir-363_R25 J1_ES_demeth ...........................................................AAUUGCACGGUAUCCAUCUG............... 1 1 hsa-mir-363_R26 J1_ES_demeth ............................................................AUUGCACGGUAUCCAUCUGUAAA........... 1 1 hsa-mir-363_R27 J1_ES_demeth .............................................................UUGCACGGUAUCCAUCUGUAAA........... 1 1 hsa-mir-363_R28 J1_ES_demeth hsa-mir-365-1 chr16:14310623-14310749 + CUGGUUCGUUACCGCAGGGAAAAUGAGGGACUUUUGGGGGCAGAUGUGUUUCCAUUCCACUAUCAUAAUGCCCCUAAAAAUCCUUAUUGCUCUUGCAGUAUUCCUCG ..((.....(((.((((((..((((((((..(((((((((((((((((.........))).)))....))))))))))).))))))))..)))))).)))..))... (-38.00) .................................................................UAAUGCCCCUAAAAAUCCUUAU.................... 16 2 hsa-mir-365-1_R01_M J1_ES_demeth .................................................................UAAUGCCCCUAAAAAUCCUUA..................... 2 2 hsa-mir-365-1_R02 J1_ES_demeth .................................................................UAAUGCCCCUAAAAAUCCUUAUU................... 1 2 hsa-mir-365-1_R03 J1_ES_demeth hsa-mir-365-2 chr17:26926523-26926673 + CCUCACCUGGAGAGUGUUCAAGGACAGCAAGAAAAAUGAGGGACUUUCAGGGGCAGCUGUGUUUUCUGACUCAGUCAUAAUGCCCCUAAAAAUCCUUAUUGUUCUUGCAGUGUGCAUCGGGCAGCGGCCAG ......((((...((((((..(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))))))..)))))))).)))))))..))).)...))))).)..)))) (-48.60) .............................................................................UAAUGCCCCUAAAAAUCCUUAU................................ 16 2 hsa-mir-365-2_R01_M J1_ES_demeth .............................................................................UAAUGCCCCUAAAAAUCCUUA................................. 2 2 hsa-mir-365-2_R02 J1_ES_demeth .............................................................................UAAUGCCCCUAAAAAUCCUUAUU............................... 1 2 hsa-mir-365-2_R03 J1_ES_demeth hsa-mir-367 chr4:113788459-113788566 - UCUUGGCUACAGGCCAUUACUGUUGCUAAUAUGCAACUCUGUUGAAUAUAAAUUGGAAUUGCACUUUAGCAAUGGUGAUGGAUUGUUAAG .((((((......((((((((((((((((..(((((.((((............)))).)))))..))))))))))))))))...)))))) (-33.90) ........................................................AAUUGCACUUUAGCAAUGGUGA............ 286 1 hsa-mir-367_R01_M J1_ES_untr .........................................................AUUGCACUUUAGCAAUGGUGA............ 112 1 hsa-mir-367_R02 J1_ES_untr .........................................................AUUGCACUUUAGCAAUGGUGA............ 85 1 hsa-mir-367_R03 ES_Dicer ........................................................AAUUGCACUUUAGCAAUGGUGA............ 83 1 hsa-mir-367_R04 ES_Dicer ........................................................AAUUGCACUUUAGCAAUGGUGA............ 76 1 hsa-mir-367_R05 J1_ES_demeth .........................................................AUUGCACUUUAGCAAUGGUGA............ 26 1 hsa-mir-367_R06 J1_ES_demeth ........................................................AAUUGCACUUUAGCAAUGGU.............. 15 1 hsa-mir-367_R07 J1_ES_demeth ........................................................AAUUGCACUUUAGCAAUGGU.............. 11 1 hsa-mir-367_R08 J1_ES_untr ........................................................AAUUGCACUUUAGCAAUGGU.............. 10 1 hsa-mir-367_R09 ES_Dicer ..........................................................UUGCACUUUAGCAAUGGUGA............ 7 1 hsa-mir-367_R10 ES_Dicer ........................................................AAUUGCACUUUAGCAAUGGUGAU........... 2 1 hsa-mir-367_R11 J1_ES_untr .......................................................GAAUUGCACUUUAGCAAUGGUGA............ 2 1 hsa-mir-367_R12 J1_ES_untr .........................................................AUUGCACUUUAGCAAUGGUGAU........... 2 1 hsa-mir-367_R13 J1_ES_untr .........................................................AUUGCACUUUAGCAAUGGU.............. 1 1 hsa-mir-367_R14 ES_Dicer .........................................................AUUGCACUUUAGCAAUGGUGAU........... 1 1 hsa-mir-367_R15 ES_Dicer ........................................................AAUUGCACUUUAGCAAUGG............... 1 1 hsa-mir-367_R16 J1_ES_untr hsa-mir-369 chr14:100601668-100601777 + UCCUGGUACUUGAAGGGAGAUCGACCGUGUUAUAUUCGCUUUAUUGACUUCGAAUAAUACAUGGUUGAUCUUUUCUCAGUAUCAAAUCUC ...(((((((.((..(((((((((((((((..((((((............))))))..)))))))))))))))..)))))))))...... (-36.00) .................AGAUCGACCGUGUUAUAUUCG.................................................... 19 1 hsa-mir-369_L01*_M J1_ES_untr .................AGAUCGACCGUGUUAUAUUCG.................................................... 10 1 hsa-mir-369_L02* J1_ES_demeth .................AGAUCGACCGUGUUAUAUUCGC................................................... 9 1 hsa-mir-369_L03* J1_ES_untr .................AGAUCGACCGUGUUAUAUUCGC................................................... 5 1 hsa-mir-369_L04* J1_ES_demeth .................AGAUCGACCGUGUUAUAUUCG.................................................... 3 1 hsa-mir-369_L05* ES_Dicer .................AGAUCGACCGUGUUAUAUUC..................................................... 2 1 hsa-mir-369_L06* J1_ES_untr .................AGAUCGACCGUGUUAUAUUCGC................................................... 1 1 hsa-mir-369_L07* ES_Dicer ....................UCGACCGUGUUAUAUUCGC................................................... 1 1 hsa-mir-369_L08* J1_ES_demeth .................AGAUCGACCGUGUUAUAUU...................................................... 1 1 hsa-mir-369_L09* J1_ES_demeth .................AGAUCGACCGUGUUAUAUUCGCU.................................................. 1 1 hsa-mir-369_L10* J1_ES_untr ...................AUCGACCGUGUUAUAUUCGC................................................... 1 1 hsa-mir-369_L11* J1_ES_untr ....................................................AAUAAUACAUGGUUGAUCUUU................. 482 1 hsa-mir-369_R01_M J1_ES_untr ....................................................AAUAAUACAUGGUUGAUCUUU................. 459 1 hsa-mir-369_R02 J1_ES_demeth ....................................................AAUAAUACAUGGUUGAUCUUUU................ 32 1 hsa-mir-369_R03 J1_ES_untr ....................................................AAUAAUACAUGGUUGAUCUUU................. 30 1 hsa-mir-369_R04 ES_Dicer ....................................................AAUAAUACAUGGUUGAUCUUUU................ 30 1 hsa-mir-369_R05 J1_ES_demeth ....................................................AAUAAUACAUGGUUGAUCUU.................. 22 1 hsa-mir-369_R06 J1_ES_demeth ...................................................GAAUAAUACAUGGUUGAUCUUU................. 18 1 hsa-mir-369_R07 J1_ES_demeth ...................................................GAAUAAUACAUGGUUGAUCUUU................. 12 1 hsa-mir-369_R08 J1_ES_untr ....................................................AAUAAUACAUGGUUGAUCUU.................. 8 1 hsa-mir-369_R09 J1_ES_untr .....................................................AUAAUACAUGGUUGAUCUUU................. 2 1 hsa-mir-369_R10 ES_Dicer ....................................................AAUAAUACAUGGUUGAUCUU.................. 2 1 hsa-mir-369_R11 ES_Dicer ....................................................AAUAAUACAUGGUUGAUCUUU................. 2 1 hsa-mir-369_R12 ES_Dicer-DEL ...................................................GAAUAAUACAUGGUUGAUCUUU................. 1 1 hsa-mir-369_R13 ES_Dicer ....................................................AAUAAUACAUGGUUGAUC.................... 1 1 hsa-mir-369_R14 J1_ES_demeth .................................................UCGAAUAAUACAUGGUUGAUCUUU................. 1 1 hsa-mir-369_R15 ES_Dicer-DEL hsa-mir-370 chr14:100447209-100447323 + UCGGGGCACAAGACAGAGAAGCCAGGUCACGUCUCUGCAGUUACACAGCUCACGAGUGCCUGCUGGGGUGGAACCUGGUCUGUCUGUCUGUCUAA ...(((((...((((((.(..((((((..(..(((.((((.(((.(.......).))).)))).)))..)..))))))..).))))))))))).. (-41.70) ......................CAGGUCACGUCUCUGCAGUUACAC................................................. 14 1 hsa-mir-370_L01_M J1_ES_untr ......................CAGGUCACGUCUCUGCAGUUAC................................................... 3 1 hsa-mir-370_L02 J1_ES_demeth ......................CAGGUCACGUCUCUGCAGUUACAC................................................. 2 1 hsa-mir-370_L03 J1_ES_demeth ......................CAGGUCACGUCUCUGCAGUUACA.................................................. 2 1 hsa-mir-370_L04 J1_ES_untr ..........................UCACGUCUCUGCAGUUAC................................................... 1 1 hsa-mir-370_L05 J1_ES_untr .........................GUCACGUCUCUGCAGUUACA.................................................. 1 1 hsa-mir-370_L06 J1_ES_untr ..........................UCACGUCUCUGCAGUUACAC................................................. 1 1 hsa-mir-370_L07 J1_ES_untr hsa-mir-374b chrX:73355087-73355198 - AAGAAAUCCUACUCGGAUGGAUAUAAUACAACCUGCUAAGUGUCCUAGCACUUAGCAGGUUGUAUUAUCAUUGUCCGUGUCUAUGGCUCUC .(((...((.((.((((..(..(((((((((((((((((((((....)))))))))))))))))))))..)..)))).))....)).))). (-42.80) ....................AUAUAAUACAACCUGCUAAGUG................................................. 78 1 hsa-mir-374b_L01_M J1_ES_untr ....................AUAUAAUACAACCUGCUAAGUG................................................. 38 1 hsa-mir-374b_L02 ES_Dicer ....................AUAUAAUACAACCUGCUAAGU.................................................. 32 1 hsa-mir-374b_L03 J1_ES_untr ....................AUAUAAUACAACCUGCUAAGU.................................................. 16 1 hsa-mir-374b_L04 ES_Dicer ....................AUAUAAUACAACCUGCUAAGUGU................................................ 10 1 hsa-mir-374b_L05 J1_ES_untr ....................AUAUAAUACAACCUGCUAAGUG................................................. 10 1 hsa-mir-374b_L06 J1_ES_demeth ....................AUAUAAUACAACCUGCUAAGU.................................................. 5 1 hsa-mir-374b_L07 J1_ES_demeth .....................UAUAAUACAACCUGCUAAGUG................................................. 1 1 hsa-mir-374b_L08 ES_Dicer .....................UAUAAUACAACCUGCUAAGU.................................................. 1 1 hsa-mir-374b_L09 ES_Dicer ....................AUAUAAUACAACCUGCUAAG................................................... 1 1 hsa-mir-374b_L10 J1_ES_demeth ....................AUAUAAUACAACCUGCUAAGUGU................................................ 1 1 hsa-mir-374b_L11 J1_ES_demeth ..................................................CUUAGCAGGUUGUAUUAUCAUU................... 17 1 hsa-mir-374b_R01*_M J1_ES_untr ..................................................CUUAGCAGGUUGUAUUAUCAUU................... 4 1 hsa-mir-374b_R02* J1_ES_demeth ..................................................CUUAGCAGGUUGUAUUAUCAUU................... 1 1 hsa-mir-374b_R03* ES_Dicer ..................................................CUUAGCAGGUUGUAUUAUCAU.................... 1 1 hsa-mir-374b_R04* J1_ES_untr ...................................................UUAGCAGGUUGUAUUAUCAUU................... 1 1 hsa-mir-374b_R05* J1_ES_demeth hsa-mir-375 chr2:219574591-219574694 - UCCGCUCCCGCCCCGCGACGAGCCCCUCGCACAAACCGGACCUGAGCGUUUUGUUCGUUCGGCUCGCGUGAGGCAGGGGCGGC .(((((((.(((.((((.((((((...((.(((((.((........)).))))).))...)))))))))).))).))))))). (-45.20) ....................................................GUUCGUUCGGCUCGCGUGA............ 1 1 hsa-mir-375_R01_M J1_ES_demeth hsa-mir-376a-1 chr14:100576852-100576959 + UUUGGUAUUUAAAAGGUAGAUUCUCCUUCUAUGAGUACAUUAUUUAUGAUUAAUCAUAGAGGAAAAUCCACGUUUUCAGUAUCAAAU (((((((((.((((.((.((((.((((.((((((...(((.....))).....)))))))))).)))).)).)))).))))))))). (-26.90) ..............GGUAGAUUCUCCUUCUAUGAGU................................................... 8 1 hsa-mir-376a-1_L01_M J1_ES_demeth ..............GGUAGAUUCUCCUUCUAUGAGU................................................... 2 1 hsa-mir-376a-1_L02 J1_ES_untr ................UAGAUUCUCCUUCUAUGAGUAC................................................. 2 1 hsa-mir-376a-1_L03 J1_ES_demeth ..............GGUAGAUUCUCCUUCUAUGAGU................................................... 1 1 hsa-mir-376a-1_L04 ES_Dicer ...............GUAGAUUCUCCUUCUAUGAGU................................................... 1 1 hsa-mir-376a-1_L05 ES_Dicer ...............GUAGAUUCUCCUUCUAUGAGUAC................................................. 1 1 hsa-mir-376a-1_L06 ES_Dicer ................UAGAUUCUCCUUCUAUGAGUAC................................................. 1 1 hsa-mir-376a-1_L07 J1_ES_untr ...............GUAGAUUCUCCUUCUAUGAGUAC................................................. 1 1 hsa-mir-376a-1_L08 J1_ES_untr ...............GUAGAUUCUCCUUCUAUGAGUA.................................................. 1 1 hsa-mir-376a-1_L09 J1_ES_demeth ...............GUAGAUUCUCCUUCUAUGAGU................................................... 1 1 hsa-mir-376a-1_L10 J1_ES_demeth ................UAGAUUCUCCUUCUAUGAGUACA................................................ 1 1 hsa-mir-376a-1_L11 J1_ES_demeth hsa-mir-376b chr14:100576506-100576645 + UCCAGAGCCCAGUCCUUCUUUGGUAUUUAAAACGUGGAUAUUCCUUCUAUGUUUACGUGAUUCCUGGUUAAUCAUAGAGGAAAAUCCAUGUUUUCAGUAUCAAAUGCUGCUUUGGAAAU ((((((((..(((.....(((((((((.(((((((((((.(((((.(((((......((((.....))))..)))))))))).))))))))))).))))))))).)))))))))))... (-44.10) .................................GUGGAUAUUCCUUCUAUGUUUA................................................................ 2 2 hsa-mir-376b_L01_M J1_ES_demeth ..................................UGGAUAUUCCUUCUAUGUUU................................................................. 1 2 hsa-mir-376b_L02 J1_ES_untr hsa-mir-376c chr14:100575760-100575865 + UUGGUAUUUAAAAGGUGGAUAUUCCUUCUAUGUUUAUGUUAUUUAUGGUUAAACAUAGAGGAAAUUCCACGUUUUCAGUAUCAAA ((((((((.((((.(((((..(((((.(((((((((.............))))))))))))))..))))).)))).)))))))). (-32.32) ..............GUGGAUAUUCCUUCUAUGUUUA................................................. 2 2 hsa-mir-376c_L01_M J1_ES_demeth ...............UGGAUAUUCCUUCUAUGUUU.................................................. 1 2 hsa-mir-376c_L02 J1_ES_untr hsa-mir-377 chr14:100598120-100598228 + GUUUGACCCUUGAGCAGAGGUUGCCCUUGGUGAAUUCGCUUUAUUUAUGUUGAAUCACACAAAGGCAACUUUUGUUUGAGUAUCAAAU ((((((..((..(((((((((((((.(((((((.(((((.........).)))))))).))).)))))))))))))..))..)))))) (-37.70) ...............AGAGGUUGCCCUUGGUGAAUUC................................................... 18 1 hsa-mir-377_L01*_M J1_ES_untr ...............AGAGGUUGCCCUUGGUGAAUUC................................................... 16 1 hsa-mir-377_L02* J1_ES_demeth ...............AGAGGUUGCCCUUGGUGAAUUCG.................................................. 8 1 hsa-mir-377_L03* J1_ES_untr ...............AGAGGUUGCCCUUGGUGAAUUCG.................................................. 3 1 hsa-mir-377_L04* J1_ES_demeth ................GAGGUUGCCCUUGGUGAAUUCG.................................................. 1 1 hsa-mir-377_L05* J1_ES_untr ................GAGGUUGCCCUUGGUGAAUUCG.................................................. 1 1 hsa-mir-377_L06* J1_ES_demeth ................GAGGUUGCCCUUGGUGAAUUC................................................... 1 1 hsa-mir-377_L07* J1_ES_demeth .................AGGUUGCCCUUGGUGAAUUCGC................................................. 1 1 hsa-mir-377_L08* J1_ES_demeth ...............AGAGGUUGCCCUUGGUGAAU..................................................... 1 1 hsa-mir-377_L09* J1_ES_demeth ...............AGAGGUUGCCCUUGGUGAAUU.................................................... 1 1 hsa-mir-377_L10* J1_ES_demeth .....................................................AUCACACAAAGGCAACUUUUGU............. 49 1 hsa-mir-377_R01_M J1_ES_untr ..................................................UGAAUCACACAAAGGCAACUUUU............... 33 1 hsa-mir-377_R02 J1_ES_demeth .....................................................AUCACACAAAGGCAACUUUUGU............. 28 1 hsa-mir-377_R03 J1_ES_demeth .....................................................AUCACACAAAGGCAACUUUUGU............. 11 1 hsa-mir-377_R04 ES_Dicer ..................................................UGAAUCACACAAAGGCAACUUUU............... 10 1 hsa-mir-377_R05 J1_ES_untr ....................................................AAUCACACAAAGGCAACUUUUGU............. 7 1 hsa-mir-377_R06 J1_ES_untr ....................................................AAUCACACAAAGGCAACUUUUGU............. 5 1 hsa-mir-377_R07 J1_ES_demeth ..................................................UGAAUCACACAAAGGCAACUUU................ 5 1 hsa-mir-377_R08 J1_ES_demeth .....................................................AUCACACAAAGGCAACUUUUG.............. 3 1 hsa-mir-377_R09 ES_Dicer .....................................................AUCACACAAAGGCAACUUUUGUU............ 3 1 hsa-mir-377_R10 ES_Dicer ....................................................AAUCACACAAAGGCAACUUUUG.............. 3 1 hsa-mir-377_R11 J1_ES_untr .....................................................AUCACACAAAGGCAACUUUUGUU............ 3 1 hsa-mir-377_R12 J1_ES_untr ..................................................UGAAUCACACAAAGGCAACUU................. 3 1 hsa-mir-377_R13 J1_ES_demeth ....................................................AAUCACACAAAGGCAACUUUUGU............. 2 1 hsa-mir-377_R14 ES_Dicer ..................................................UGAAUCACACAAAGGCAACUUU................ 2 1 hsa-mir-377_R15 J1_ES_untr .....................................................AUCACACAAAGGCAACUUUUG.............. 2 1 hsa-mir-377_R16 J1_ES_demeth ....................................................AAUCACACAAAGGCAACUUUUG.............. 1 1 hsa-mir-377_R17 ES_Dicer .......................................................CACACAAAGGCAACUUUUGU............. 1 1 hsa-mir-377_R18 ES_Dicer ......................................................UCACACAAAGGCAACUUUU............... 1 1 hsa-mir-377_R19 J1_ES_demeth ....................................................AAUCACACAAAGGCAACUUUUG.............. 1 1 hsa-mir-377_R20 J1_ES_demeth hsa-mir-378 chr5:149092561-149092666 + GAGCCACCCAGGGCUCCUGACUCCAGGUCCUGUGUGUUACCUAGAAAUAGCACUGGACUUGGAGUCAGAAGGCCUGAGUGGAGUC ...((((.((((.((.((((((((((((((...((((((........)))))).)))))))))))))).)).)))).)))).... (-50.40) ..............UCCUGACUCCAGGUCCUGUGUGU................................................ 1 1 hsa-mir-378_L01*_M ES_Dicer .............CUCCUGACUCCAGGUCCUGUGU.................................................. 1 1 hsa-mir-378_L02* J1_ES_untr .............CUCCUGACUCCAGGUCCUGUGU.................................................. 1 1 hsa-mir-378_L03* J1_ES_demeth ...................................................ACUGGACUUGGAGUCAGAAGGC............ 19 1 hsa-mir-378_R01_M J1_ES_demeth ...................................................ACUGGACUUGGAGUCAGAAGGC............ 10 1 hsa-mir-378_R02 ES_Dicer ...................................................ACUGGACUUGGAGUCAGAAGGC............ 10 1 hsa-mir-378_R03 J1_ES_untr ...................................................ACUGGACUUGGAGUCAGAAG.............. 6 1 hsa-mir-378_R04 ES_Dicer ....................................................CUGGACUUGGAGUCAGAAGGC............ 6 1 hsa-mir-378_R05 J1_ES_untr ...................................................ACUGGACUUGGAGUCAGAAG.............. 4 1 hsa-mir-378_R06 J1_ES_demeth ....................................................CUGGACUUGGAGUCAGAAGGC............ 2 1 hsa-mir-378_R07 ES_Dicer ...................................................ACUGGACUUGGAGUCAGAA............... 1 1 hsa-mir-378_R08 J1_ES_demeth ....................................................CUGGACUUGGAGUCAGAAGGC............ 1 1 hsa-mir-378_R09 J1_ES_demeth hsa-mir-379 chr14:100558136-100558242 + GGUUCCUGAAGAGAUGGUAGACUAUGGAACGUAGGCGUUAUGAUUUCUGACCUAUGUAACAUGGUCCACUAACUCUCAGUAUCCAA ((...((((.(((.((((.(((((((..(((((((((..(....)..)).)))))))..))))))).)))).)))))))...)).. (-33.60) ..............UGGUAGACUAUGGAACGUAG.................................................... 6 1 hsa-mir-379_L01*_M J1_ES_demeth ..............UGGUAGACUAUGGAACGUAG.................................................... 2 1 hsa-mir-379_L02* ES_Dicer ..............UGGUAGACUAUGGAACGUAGGC.................................................. 2 1 hsa-mir-379_L03* J1_ES_demeth ..............UGGUAGACUAUGGAACGUAG.................................................... 1 1 hsa-mir-379_L04* J1_ES_untr ....................................................UAUGUAACAUGGUCCACUAAC............. 226 1 hsa-mir-379_R01_M J1_ES_untr ....................................................UAUGUAACAUGGUCCACUAAC............. 104 1 hsa-mir-379_R02 J1_ES_demeth ....................................................UAUGUAACAUGGUCCACUAA.............. 17 1 hsa-mir-379_R03 J1_ES_demeth ....................................................UAUGUAACAUGGUCCACUAAC............. 16 1 hsa-mir-379_R04 ES_Dicer ....................................................UAUGUAACAUGGUCCACUAA.............. 11 1 hsa-mir-379_R05 J1_ES_untr ....................................................UAUGUAACAUGGUCCACUAACU............ 5 1 hsa-mir-379_R06 J1_ES_untr ....................................................UAUGUAACAUGGUCCACUAACU............ 2 1 hsa-mir-379_R07 ES_Dicer .......................................................GUAACAUGGUCCACUAAC............. 2 1 hsa-mir-379_R08 J1_ES_demeth ....................................................UAUGUAACAUGGUCCACUAA.............. 1 1 hsa-mir-379_R09 ES_Dicer ...................................................CUAUGUAACAUGGUCCACUAAC............. 1 1 hsa-mir-379_R10 J1_ES_untr ....................................................UAUGUAACAUGGUCCACUA............... 1 1 hsa-mir-379_R11 J1_ES_demeth ....................................................UAUGUAACAUGGUCCACUAACU............ 1 1 hsa-mir-379_R12 J1_ES_demeth ...................................................CUAUGUAACAUGGUCCACUA............... 1 1 hsa-mir-379_R13 J1_ES_demeth hsa-mir-380 chr14:100561087-100561187 + GUACCUGAAAAGAUGGUUGACCAUAGAACAUGCGCUAUCUCUGUGUCGUAUGUAAUAUGGUCCACAUCUUCUCAAUAUCA .....(((.((((((...(((((((..(((((((.(((....))).)))))))..)))))))..)))))).)))...... (-28.50) ............AUGGUUGACCAUAGAACAUGCG.............................................. 8 1 hsa-mir-380_L01_M J1_ES_untr ............AUGGUUGACCAUAGAACAUGCG.............................................. 3 1 hsa-mir-380_L02 J1_ES_demeth hsa-mir-381 chr14:100581990-100582104 + AUUGUUUGGUACUUAAAGCGAGGUUGCCCUUUGUAUAUUCGGUUUAUUGACAUGGAAUAUACAAGGGCAAGCUCUCUGUGAGUAUCAAACCUUGU ...((((((((((((.((.(((.((((((((.((((((((.(((....)))...)))))))))))))))).))).)).))))))))))))..... (-45.30) ................AGCGAGGUUGCCCUUUGUAUAUU........................................................ 10 1 hsa-mir-381_L01*_M J1_ES_untr ................AGCGAGGUUGCCCUUUGUAUAUU........................................................ 6 1 hsa-mir-381_L02* J1_ES_demeth ................AGCGAGGUUGCCCUUUGUAU........................................................... 2 1 hsa-mir-381_L03* J1_ES_demeth ................AGCGAGGUUGCCCUUUGUAUAUUC....................................................... 1 1 hsa-mir-381_L04* J1_ES_demeth ................AGCGAGGUUGCCCUUUGUAUAU......................................................... 1 1 hsa-mir-381_L05* J1_ES_demeth .........................................................UAUACAAGGGCAAGCUCUCUGU................ 13 1 hsa-mir-381_R01_M J1_ES_demeth .........................................................UAUACAAGGGCAAGCUCUCUGU................ 12 1 hsa-mir-381_R02 J1_ES_untr .........................................................UAUACAAGGGCAAGCUCUCUG................. 4 1 hsa-mir-381_R03 ES_Dicer .........................................................UAUACAAGGGCAAGCUCUCUGU................ 4 1 hsa-mir-381_R04 ES_Dicer ........................................................AUAUACAAGGGCAAGCUCUCUGU................ 3 1 hsa-mir-381_R05 J1_ES_untr .........................................................UAUACAAGGGCAAGCUCUCU.................. 2 1 hsa-mir-381_R06 ES_Dicer ........................................................AUAUACAAGGGCAAGCUCUCU.................. 2 1 hsa-mir-381_R07 ES_Dicer .........................................................UAUACAAGGGCAAGCUCUCUG................. 2 1 hsa-mir-381_R08 J1_ES_untr .........................................................UAUACAAGGGCAAGCUCUCU.................. 2 1 hsa-mir-381_R09 J1_ES_demeth .........................................................UAUACAAGGGCAAGCUCUCUG................. 2 1 hsa-mir-381_R10 J1_ES_demeth ........................................................AUAUACAAGGGCAAGCUCUCUG................. 1 1 hsa-mir-381_R11 J1_ES_untr hsa-mir-382 chr14:100590376-100590491 + UUUCUGUGGUACUUGAAGAGAAGUUGUUCGUGGUGGAUUCGCUUUACUUAUGACGAAUCAUUCACGGACAACACUUUUUUCAGUACCAAAUGCUA ......(((((((.(((((((.(((((((((((..(((((((.........).))))))..)))))))))))..))))))))))))))....... (-37.10) ...................GAAGUUGUUCGUGGUGGAUUCG...................................................... 12 1 hsa-mir-382_L01*_M J1_ES_untr ...................GAAGUUGUUCGUGGUGGAUUCG...................................................... 7 1 hsa-mir-382_L02* J1_ES_demeth ....................AAGUUGUUCGUGGUGGAUUCG...................................................... 3 1 hsa-mir-382_L03* J1_ES_demeth ...................GAAGUUGUUCGUGGUGGAUUCG...................................................... 2 1 hsa-mir-382_L04* ES_Dicer ...................GAAGUUGUUCGUGGUGGAUUC....................................................... 2 1 hsa-mir-382_L05* J1_ES_demeth ....................AAGUUGUUCGUGGUGGAUUCG...................................................... 1 1 hsa-mir-382_L06* ES_Dicer .....................AGUUGUUCGUGGUGGAUUCGCU.................................................... 1 1 hsa-mir-382_L07* J1_ES_untr .......................................................AAUCAUUCACGGACAACACUUU.................. 93 1 hsa-mir-382_R01_M J1_ES_untr .......................................................AAUCAUUCACGGACAACACUUU.................. 65 1 hsa-mir-382_R02 J1_ES_demeth .......................................................AAUCAUUCACGGACAACACUU................... 16 1 hsa-mir-382_R03 J1_ES_untr .......................................................AAUCAUUCACGGACAACACUU................... 10 1 hsa-mir-382_R04 ES_Dicer .......................................................AAUCAUUCACGGACAACACUU................... 7 1 hsa-mir-382_R05 J1_ES_demeth .......................................................AAUCAUUCACGGACAACACUUUU................. 6 1 hsa-mir-382_R06 J1_ES_demeth ........................................................AUCAUUCACGGACAACACUUU.................. 5 1 hsa-mir-382_R07 J1_ES_untr .......................................................AAUCAUUCACGGACAACACUUU.................. 4 1 hsa-mir-382_R08 ES_Dicer ........................................................AUCAUUCACGGACAACACUUU.................. 3 1 hsa-mir-382_R09 J1_ES_demeth .......................................................AAUCAUUCACGGACAACACUUUU................. 1 1 hsa-mir-382_R10 J1_ES_untr .............................................................UCACGGACAACACUUUUUUCAG............ 1 1 hsa-mir-382_R11 J1_ES_demeth .....................................................CGAAUCAUUCACGGACAACACUU................... 1 1 hsa-mir-382_R12 J1_ES_demeth hsa-mir-409 chr14:100601370-100601488 + GCCUCUCCAUGGUACUCGGGGAGAGGUUACCCGAGCAACUUUGCAUCUGGACGACGAAUGUUGCUCGGUGAACCCCUUUUCGGUAUCAAAUUCCACCA .........((((((.((..(((.((((..((((((((((((((........).)))).)))))))))..)))).)))..)))))))).......... (-39.30) .......................AGGUUACCCGAGCAACUUUGCAU.................................................... 9 1 hsa-mir-409_L01_M J1_ES_untr .......................AGGUUACCCGAGCAACUUUGCAUC................................................... 7 1 hsa-mir-409_L02 J1_ES_untr .......................AGGUUACCCGAGCAACUUUGCAU.................................................... 6 1 hsa-mir-409_L03 J1_ES_demeth .......................AGGUUACCCGAGCAACUUUGCAUCU.................................................. 5 1 hsa-mir-409_L04 J1_ES_untr .......................AGGUUACCCGAGCAACUUUGCA..................................................... 3 1 hsa-mir-409_L05 J1_ES_untr .......................AGGUUACCCGAGCAACUUUGCAUC................................................... 2 1 hsa-mir-409_L06 J1_ES_demeth .......................AGGUUACCCGAGCAACUUUGC...................................................... 1 1 hsa-mir-409_L07 ES_Dicer .......................AGGUUACCCGAGCAACUUUGCA..................................................... 1 1 hsa-mir-409_L08 J1_ES_demeth .......................................................GAAUGUUGCUCGGUGAACCCCU..................... 4 1 hsa-mir-409_R01*_M ES_Dicer ......................................................CGAAUGUUGCUCGGUGAACC........................ 2 1 hsa-mir-409_R02* J1_ES_demeth .......................................................GAAUGUUGCUCGGUGAACCCCUU.................... 1 1 hsa-mir-409_R03* ES_Dicer ........................................................AAUGUUGCUCGGUGAACCCCU..................... 1 1 hsa-mir-409_R04* ES_Dicer .......................................................GAAUGUUGCUCGGUGAACCCC...................... 1 1 hsa-mir-409_R05* J1_ES_untr .......................................................GAAUGUUGCUCGGUGAACC........................ 1 1 hsa-mir-409_R06* J1_ES_demeth .......................................................GAAUGUUGCUCGGUGAACCCCU..................... 1 1 hsa-mir-409_R07* J1_ES_demeth ......................................................CGAAUGUUGCUCGGUGAAC......................... 1 1 hsa-mir-409_R08* J1_ES_demeth hsa-mir-410 chr14:100601982-100602101 + GGCACUCUGGGUACCUGAGAAGAGGUUGUCUGUGAUGAGUUCGCUUUUAUUAAUGACGAAUAUAACACAGAUGGCCUGUUUUCAGUACCGCUACCGCCCGG (((.....((((((.((((((.((((..((((((.((.((((((..........).))))).)).))))))..)))).))))))))))).)....)))... (-41.50) ......................AGGUUGUCUGUGAUGAGUUCG.......................................................... 3 1 hsa-mir-410_L01*_M J1_ES_untr ......................AGGUUGUCUGUGAUGAGUUCG.......................................................... 1 1 hsa-mir-410_L02* J1_ES_demeth ..........................................................AAUAUAACACAGAUGGCCUGU...................... 131 1 hsa-mir-410_R01_M J1_ES_demeth ..........................................................AAUAUAACACAGAUGGCCUGU...................... 129 1 hsa-mir-410_R02 J1_ES_untr ..........................................................AAUAUAACACAGAUGGCCUGU...................... 38 1 hsa-mir-410_R03 ES_Dicer ..........................................................AAUAUAACACAGAUGGCCUG....................... 3 1 hsa-mir-410_R04 J1_ES_untr ..........................................................AAUAUAACACAGAUGGCCUGUU..................... 3 1 hsa-mir-410_R05 J1_ES_untr ..........................................................AAUAUAACACAGAUGGCCUGUU..................... 2 1 hsa-mir-410_R06 J1_ES_demeth ...........................................................AUAUAACACAGAUGGCCUGU...................... 1 1 hsa-mir-410_R07 ES_Dicer ..........................................................AAUAUAACACAGAUGGCCUG....................... 1 1 hsa-mir-410_R08 ES_Dicer hsa-mir-411 chr14:100559395-100559530 + AUCUCUGUGUGGUACUUGGAGAGAUAGUAGACCGUAUAGCGUACGCUUUAUCUGUGACGUAUGUAACACGGUCCACUAACCCUCAGUAUCAAAUCCAUCCCCGAGGCUCCUGGAA .........(((((((..(((.(.((((.((((((.(.((((((((.........).))))))).).)))))).)))).).))))))))))..((((.((....))....)))). (-34.00) ........................UAGUAGACCGUAUAGCGUACG...................................................................... 87 1 hsa-mir-411_L01*_M J1_ES_untr ........................UAGUAGACCGUAUAGCGUACG...................................................................... 30 1 hsa-mir-411_L02* J1_ES_demeth ........................UAGUAGACCGUAUAGCGUACG...................................................................... 20 1 hsa-mir-411_L03* ES_Dicer .......................AUAGUAGACCGUAUAGCGUACG...................................................................... 11 1 hsa-mir-411_L04* J1_ES_untr ........................UAGUAGACCGUAUAGCGUAC....................................................................... 5 1 hsa-mir-411_L05* J1_ES_untr .......................AUAGUAGACCGUAUAGCGUAC....................................................................... 5 1 hsa-mir-411_L06* J1_ES_untr ........................UAGUAGACCGUAUAGCGUAC....................................................................... 5 1 hsa-mir-411_L07* J1_ES_demeth ........................UAGUAGACCGUAUAGCGUAC....................................................................... 4 1 hsa-mir-411_L08* ES_Dicer .......................AUAGUAGACCGUAUAGCGUACG...................................................................... 3 1 hsa-mir-411_L09* J1_ES_demeth .........................AGUAGACCGUAUAGCGUACG...................................................................... 2 1 hsa-mir-411_L10* J1_ES_untr .......................AUAGUAGACCGUAUAGCGUAC....................................................................... 2 1 hsa-mir-411_L11* J1_ES_demeth ........................UAGUAGACCGUAUAGCGUACGC..................................................................... 1 1 hsa-mir-411_L12* J1_ES_untr ...........................................................UAUGUAACACGGUCCACUAAC................................... 784 1 hsa-mir-411_R01_M J1_ES_untr ...........................................................UAUGUAACACGGUCCACUAAC................................... 339 1 hsa-mir-411_R02 J1_ES_demeth ...........................................................UAUGUAACACGGUCCACUAA.................................... 135 1 hsa-mir-411_R03 J1_ES_demeth ...........................................................UAUGUAACACGGUCCACUAA.................................... 88 1 hsa-mir-411_R04 J1_ES_untr ...........................................................UAUGUAACACGGUCCACUAAC................................... 28 1 hsa-mir-411_R05 ES_Dicer ...........................................................UAUGUAACACGGUCCACUAACC.................................. 20 1 hsa-mir-411_R06 J1_ES_untr ...........................................................UAUGUAACACGGUCCACUA..................................... 18 1 hsa-mir-411_R07 J1_ES_demeth ...........................................................UAUGUAACACGGUCCACUAA.................................... 8 1 hsa-mir-411_R08 ES_Dicer ...........................................................UAUGUAACACGGUCCACUA..................................... 6 1 hsa-mir-411_R09 J1_ES_untr ...........................................................UAUGUAACACGGUCCACUAACC.................................. 6 1 hsa-mir-411_R10 J1_ES_demeth ..........................................................GUAUGUAACACGGUCCACUAAC................................... 4 1 hsa-mir-411_R11 J1_ES_untr ..........................................................GUAUGUAACACGGUCCACUAAC................................... 3 1 hsa-mir-411_R12 J1_ES_demeth ............................................................AUGUAACACGGUCCACUAAC................................... 2 1 hsa-mir-411_R13 J1_ES_untr ...........................................................UAUGUAACACGGUCCACUAACC.................................. 1 1 hsa-mir-411_R14 ES_Dicer ............................................................AUGUAACACGGUCCACUAAC................................... 1 1 hsa-mir-411_R15 ES_Dicer .........................................................CGUAUGUAACACGGUCCACUAA.................................... 19 1 hsa-mir-411_O01 J1_ES_demeth .........................................................CGUAUGUAACACGGUCCACUAA.................................... 8 1 hsa-mir-411_O02 J1_ES_untr .........................................................CGUAUGUAACACGGUCCACU...................................... 2 1 hsa-mir-411_O03 J1_ES_demeth .........................................................CGUAUGUAACACGGUCCACUA..................................... 1 1 hsa-mir-411_O04 J1_ES_demeth hsa-mir-421 chrX:73354917-73355041 - CUAAUCCGGUGCACAUUGUAGGCCUCAUUAAAUGUUUGUUGAAUGAAAAAAUGAAUCAUCAACAGACAUUAAUUGGGCGCCUGCUCUGUGAUCUCCAUGGGCUC ....(((((..((((..((((((((((...((((((((((((.(((.........)))))))))))))))...)))).))))))..))))....))..)))... (-38.30) .........................................................AUCAACAGACAUUAAUUGGGCGC........................ 4 1 hsa-mir-421_R01_M J1_ES_untr .........................................................AUCAACAGACAUUAAUUGGGCG......................... 3 1 hsa-mir-421_R02 J1_ES_demeth .........................................................AUCAACAGACAUUAAUUGGGCG......................... 3 1 hsa-mir-421_R03 J1_ES_untr .........................................................AUCAACAGACAUUAAUUGGGC.......................... 2 1 hsa-mir-421_R04 J1_ES_demeth ..........................................................UCAACAGACAUUAAUUGGGCGC........................ 1 1 hsa-mir-421_R05 J1_ES_demeth .........................................................AUCAACAGACAUUAAUUGGG........................... 1 1 hsa-mir-421_R06 J1_ES_demeth .........................................................AUCAACAGACAUUAAUUGGG........................... 1 1 hsa-mir-421_R07 J1_ES_untr hsa-mir-423 chr17:25468203-25468336 + UGUGAGGAAAUAAAGGAAGUUAGGCUGAGGGGCAGAGAGCGAGACUUUUCUAUUUUCCAAAAGCUCGGUCUGAGGCCCCUCAGUCUUGCUUCCUAACCCGCGCUUGAGUUUCU .(((.((......(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).)))))))...)).))).......... (-52.20) .........................UGAGGGGCAGAGAGCGAGACUUU................................................................. 16 1 hsa-mir-423_L01_M J1_ES_untr .........................UGAGGGGCAGAGAGCGAGACUUU................................................................. 13 1 hsa-mir-423_L02 J1_ES_demeth .........................UGAGGGGCAGAGAGCGAGACUUUU................................................................ 4 1 hsa-mir-423_L03 J1_ES_demeth .........................UGAGGGGCAGAGAGCGAGACUUU................................................................. 3 1 hsa-mir-423_L04 ES_Dicer .........................UGAGGGGCAGAGAGCGAGACUU.................................................................. 3 1 hsa-mir-423_L05 J1_ES_demeth .........................UGAGGGGCAGAGAGCGAGAC.................................................................... 1 1 hsa-mir-423_L06 ES_Dicer .........................UGAGGGGCAGAGAGCGAGACUU.................................................................. 1 1 hsa-mir-423_L07 J1_ES_untr .........................UGAGGGGCAGAGAGCGAGACUUUU................................................................ 1 1 hsa-mir-423_L08 J1_ES_untr .........................UGAGGGGCAGAGAGCGAGACU................................................................... 1 1 hsa-mir-423_L09 J1_ES_demeth .............................................................AGCUCGGUCUGAGGCCCCUCAGU............................. 11 1 hsa-mir-423_R01*_M J1_ES_demeth .............................................................AGCUCGGUCUGAGGCCCCUCAGU............................. 7 1 hsa-mir-423_R02* ES_Dicer .............................................................AGCUCGGUCUGAGGCCCCUCA............................... 2 1 hsa-mir-423_R03* ES_Dicer .............................................................AGCUCGGUCUGAGGCCCCUCAGU............................. 2 1 hsa-mir-423_R04* J1_ES_untr ............................................................AAGCUCGGUCUGAGGCCCCUCAGU............................. 2 1 hsa-mir-423_R05* J1_ES_demeth ............................................................AAGCUCGGUCUGAGGCCCCUCAGU............................. 1 1 hsa-mir-423_R06* ES_Dicer ..............................................................GCUCGGUCUGAGGCCCCUCAGU............................. 1 1 hsa-mir-423_R07* J1_ES_untr .............................................................AGCUCGGUCUGAGGCCCCUCA............................... 1 1 hsa-mir-423_R08* J1_ES_demeth hsa-mir-424 chrX:133508290-133508427 - CUUCAUUGACUCCGAGGGGAUACAGCAGCAAUUCAUGUUUUGAAGUGUUCUAAAUGGUUCAAAACGUGAGGCGCUGCUAUACCCCCUCGUGGGGAAGGUAGAAGGUGGGGUCUGCCGGA .........((((((((((.((.((((((..(((((((((((((.(((.....))).)))))))))))))..)))))).)).))))))).)))...((((((........))))))... (-54.50) ......................CAGCAGCAAUUCAUGUUUUG............................................................................. 68 1 hsa-mir-424_L01_M J1_ES_demeth ......................CAGCAGCAAUUCAUGUUUUG............................................................................. 3 1 hsa-mir-424_L02 ES_Dicer ......................CAGCAGCAAUUCAUGUUUUG............................................................................. 3 1 hsa-mir-424_L03 J1_ES_untr ......................CAGCAGCAAUUCAUGUUUUGAA........................................................................... 1 1 hsa-mir-424_L04 J1_ES_demeth ......................CAGCAGCAAUUCAUGUUUUGA............................................................................ 1 1 hsa-mir-424_L05 J1_ES_demeth hsa-mir-425 chr3:49032565-49032691 - CUUCAGAAUGGAAAGCGCUUUGGAAUGACACGAUCACUCCCGUUGAGUGGGCACCCGAGAAGCCAUCGGGAAUGUCGUGUCCGCCCAGUGCUCUUUCGGCGCCUCCC ..........(((((.((.((((...(((((((((((((.....)))))....(((((.......)))))...))))))))...)))).)).))))).......... (-38.00) .......................AAUGACACGAUCACUCCCGUUGA............................................................. 103 1 hsa-mir-425_L01_M J1_ES_demeth .......................AAUGACACGAUCACUCCCGUUGAGU........................................................... 64 1 hsa-mir-425_L02 J1_ES_demeth .......................AAUGACACGAUCACUCCCGUUG.............................................................. 61 1 hsa-mir-425_L03 J1_ES_demeth .......................AAUGACACGAUCACUCCCGUUGA............................................................. 53 1 hsa-mir-425_L04 J1_ES_untr .......................AAUGACACGAUCACUCCCGUUGAGU........................................................... 32 1 hsa-mir-425_L05 J1_ES_untr .......................AAUGACACGAUCACUCCCGUUG.............................................................. 26 1 hsa-mir-425_L06 J1_ES_untr .......................AAUGACACGAUCACUCCCGUUGAG............................................................ 22 1 hsa-mir-425_L07 J1_ES_demeth .......................AAUGACACGAUCACUCCCGUUG.............................................................. 7 1 hsa-mir-425_L08 ES_Dicer .......................AAUGACACGAUCACUCCCGUUGA............................................................. 6 1 hsa-mir-425_L09 ES_Dicer .......................AAUGACACGAUCACUCCCGUU............................................................... 5 1 hsa-mir-425_L10 J1_ES_demeth .......................AAUGACACGAUCACUCCCGUUGAGU........................................................... 4 1 hsa-mir-425_L11 ES_Dicer .......................AAUGACACGAUCACUCCCGUU............................................................... 3 1 hsa-mir-425_L12 ES_Dicer .......................AAUGACACGAUCACUCCCGUUGAG............................................................ 3 1 hsa-mir-425_L13 J1_ES_untr ........................AUGACACGAUCACUCCCGUUGAGU........................................................... 3 1 hsa-mir-425_L14 J1_ES_demeth .......................AAUGACACGAUCACUCCCGUUGAG............................................................ 2 1 hsa-mir-425_L15 ES_Dicer .......................AAUGACACGAUCACUCCCGUU............................................................... 2 1 hsa-mir-425_L16 J1_ES_untr .............................ACGAUCACUCCCGUUGAGU........................................................... 2 1 hsa-mir-425_L17 J1_ES_demeth ......................GAAUGACACGAUCACUCCCGUUGAGU........................................................... 1 1 hsa-mir-425_L18 J1_ES_demeth ................................................................AUCGGGAAUGUCGUGUCCGCC...................... 4 1 hsa-mir-425_R01*_M J1_ES_demeth ................................................................AUCGGGAAUGUCGUGUCCGC....................... 1 1 hsa-mir-425_R02* ES_Dicer ................................................................AUCGGGAAUGUCGUGUCCGC....................... 1 1 hsa-mir-425_R03* J1_ES_demeth ...............................................................CAUCGGGAAUGUCGUGUCCGCC...................... 1 1 hsa-mir-425_R04* J1_ES_demeth hsa-mir-431 chr14:100417077-100417230 + ACGUCGUUGUCCUGCUUGUCCUGCGAGGUGUCUUGCAGGCCGUCAUGCAGGCCACACUGACGGUAACGUUGCAGGUCGUCUUGCAGGGCUUCUCGCAAGACGACAUCCUCAUCACCAACGACGUGCAGCUCCA (((((((((........((((((((((..(.(((((.((((........)))).....((((....))))))))).)..)))))))))).((((....)).))............)))))))))......... (-56.00) ............................UGUCUUGCAGGCCGUCAUGCA.................................................................................... 75 1 hsa-mir-431_L01_M J1_ES_untr ............................UGUCUUGCAGGCCGUCAUGC..................................................................................... 68 1 hsa-mir-431_L02 J1_ES_demeth ............................UGUCUUGCAGGCCGUCAUGCA.................................................................................... 38 1 hsa-mir-431_L03 J1_ES_demeth ............................UGUCUUGCAGGCCGUCAUGC..................................................................................... 29 1 hsa-mir-431_L04 J1_ES_untr ............................UGUCUUGCAGGCCGUCAUG...................................................................................... 12 1 hsa-mir-431_L05 J1_ES_demeth ............................UGUCUUGCAGGCCGUCAUGCA.................................................................................... 7 1 hsa-mir-431_L06 ES_Dicer ............................UGUCUUGCAGGCCGUCAUGCAG................................................................................... 5 1 hsa-mir-431_L07 J1_ES_untr ............................UGUCUUGCAGGCCGUCAUGCAG................................................................................... 4 1 hsa-mir-431_L08 J1_ES_demeth ............................UGUCUUGCAGGCCGUCAUG...................................................................................... 3 1 hsa-mir-431_L09 J1_ES_untr ............................UGUCUUGCAGGCCGUCAUGC..................................................................................... 2 1 hsa-mir-431_L10 ES_Dicer ............................UGUCUUGCAGGCCGUCAUGCAG................................................................................... 1 1 hsa-mir-431_L11 ES_Dicer .......................................................................CAGGUCGUCUUGCAGGGCUUC......................................... 3 1 hsa-mir-431_R01*_M J1_ES_demeth ....................................................................UUGCAGGUCGUCUUGCAGGG............................................. 3 1 hsa-mir-431_R02* J1_ES_demeth ....................................................................UUGCAGGUCGUCUUGCAGGGCU........................................... 2 1 hsa-mir-431_R03* J1_ES_untr .....................................................................UGCAGGUCGUCUUGCAGGGCUUC......................................... 2 1 hsa-mir-431_R04* J1_ES_demeth ....................................................................UUGCAGGUCGUCUUGCAGGGCUUCU........................................ 1 1 hsa-mir-431_R05* J1_ES_untr .....................................................................UGCAGGUCGUCUUGCAGGGCUUC......................................... 1 1 hsa-mir-431_R06* J1_ES_untr ...................................................................GUUGCAGGUCGUCUUGCAGGG............................................. 1 1 hsa-mir-431_R07* J1_ES_demeth hsa-mir-433 chr14:100417956-100418088 + ACCCAAUGCCCGGGGAGAAGUACGGUGAGCCUGUCAUUAUUCAGAGAGGCUAGAUCCUCUGUGUUGAGAAGGAUCAUGAUGGGCUCCUCGGUGUUCUCCAGGUAGCGGCACC ..((..((((...((((((...(((.(((((((((((.(((((.(((((......))))).))........))).))))))))))).)))...)))))).))))..)).... (-43.40) ....................UACGGUGAGCCUGUCAUUAUUC...................................................................... 5 1 hsa-mir-433_L01*_M J1_ES_untr ....................UACGGUGAGCCUGUCAUUAUUC...................................................................... 5 1 hsa-mir-433_L02* J1_ES_demeth ....................UACGGUGAGCCUGUCAUUAUU....................................................................... 4 1 hsa-mir-433_L03* J1_ES_demeth ........................................................................AUCAUGAUGGGCUCCUCGGUGU.................. 190 1 hsa-mir-433_R01_M J1_ES_untr ........................................................................AUCAUGAUGGGCUCCUCGGUGU.................. 86 1 hsa-mir-433_R02 J1_ES_demeth .........................................................................UCAUGAUGGGCUCCUCGGUGU.................. 7 1 hsa-mir-433_R03 J1_ES_untr ........................................................................AUCAUGAUGGGCUCCUCGGUGU.................. 5 1 hsa-mir-433_R04 ES_Dicer .......................................................................GAUCAUGAUGGGCUCCUCGGUGU.................. 4 1 hsa-mir-433_R05 J1_ES_untr .........................................................................UCAUGAUGGGCUCCUCGGUGU.................. 4 1 hsa-mir-433_R06 J1_ES_demeth ........................................................................AUCAUGAUGGGCUCCUCGGUGUU................. 1 1 hsa-mir-433_R07 J1_ES_untr ..........................................................................CAUGAUGGGCUCCUCGGUGU.................. 1 1 hsa-mir-433_R08 J1_ES_demeth hsa-mir-449a chr5:54502097-54502227 - UGAAGUGCUCUGGAUACCUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACAAUGAACAUC ..................((((((..(((((.(((((((((((.((((((((((....(((....)))..)))))))))))))).))))))).)))))..))))))........... (-39.00) ................................UGGCAGUGUAUUGUUAGCUGGU............................................................... 5 1 hsa-mir-449a_L01_M J1_ES_untr ................................UGGCAGUGUAUUGUUAGCUGGU............................................................... 2 1 hsa-mir-449a_L02 J1_ES_demeth hsa-mir-450a-1 chrX:133502017-133502147 - AGGCAAUCAAAAACGAUACUAAACUGUUUUUGCGAUGUGUUCCUAAUAUGCACUAUAAAUAUAUUGGGAACAUUUUGCAUGUAUAGUUUUGUAUCAAUAUACAGAUGAAA ..............(((((.(((((((...(((((.((((((((((((((.........)))))))))))))).)))))...))))))).)))))............... (-35.40) ...........................UUUUGCGAUGUGUUCCUAAUAU............................................................. 26 2 hsa-mir-450a-1_L01_M J1_ES_demeth ...........................UUUUGCGAUGUGUUCCUAAUAU............................................................. 13 2 hsa-mir-450a-1_L02 J1_ES_untr ...........................UUUUGCGAUGUGUUCCUAAUA.............................................................. 3 2 hsa-mir-450a-1_L03 J1_ES_untr ...........................UUUUGCGAUGUGUUCCUAAUA.............................................................. 3 2 hsa-mir-450a-1_L04 J1_ES_demeth ...........................UUUUGCGAUGUGUUCCUAAUA.............................................................. 2 2 hsa-mir-450a-1_L05 ES_Dicer ...........................UUUUGCGAUGUGUUCCUAAUAU............................................................. 2 2 hsa-mir-450a-1_L06 ES_Dicer ..........................UUUUUGCGAUGUGUUCCUAAUAU............................................................. 1 2 hsa-mir-450a-1_L07 J1_ES_untr ............................UUUGCGAUGUGUUCCUAAUAU............................................................. 1 2 hsa-mir-450a-1_L08 J1_ES_untr ...........................UUUUGCGAUGUGUUCCUAAU............................................................... 1 2 hsa-mir-450a-1_L09 J1_ES_untr ...........................UUUUGCGAUGUGUUCCUAAU............................................................... 1 2 hsa-mir-450a-1_L10 J1_ES_demeth ..........................UUUUUGCGAUGUGUUCCUAAUAU............................................................. 1 2 hsa-mir-450a-1_L11 J1_ES_demeth hsa-mir-450a-2 chrX:133502184-133502323 - AUAAAGGUGACCAAAGAAAGAUGCUAAACUAUUUUUGCGAUGUGUUCCUAAUAUGUAAUAUAAAUGUAUUGGGGACAUUUUGCAUUCAUAGUUUUGUAUCAAUAAUAUGGGGAAAAGAG ..........(((......(((((.(((((((...(((((.(((((((((((((((.......))))))))))))))).)))))...))))))).))))).......)))......... (-36.72) ................................UUUUGCGAUGUGUUCCUAAUAU................................................................. 26 2 hsa-mir-450a-2_L01_M J1_ES_demeth ................................UUUUGCGAUGUGUUCCUAAUAU................................................................. 13 2 hsa-mir-450a-2_L02 J1_ES_untr ................................UUUUGCGAUGUGUUCCUAAUA.................................................................. 3 2 hsa-mir-450a-2_L03 J1_ES_untr ................................UUUUGCGAUGUGUUCCUAAUA.................................................................. 3 2 hsa-mir-450a-2_L04 J1_ES_demeth ................................UUUUGCGAUGUGUUCCUAAUA.................................................................. 2 2 hsa-mir-450a-2_L05 ES_Dicer ................................UUUUGCGAUGUGUUCCUAAUAU................................................................. 2 2 hsa-mir-450a-2_L06 ES_Dicer ...............................UUUUUGCGAUGUGUUCCUAAUAU................................................................. 1 2 hsa-mir-450a-2_L07 J1_ES_untr .................................UUUGCGAUGUGUUCCUAAUAU................................................................. 1 2 hsa-mir-450a-2_L08 J1_ES_untr ................................UUUUGCGAUGUGUUCCUAAU................................................................... 1 2 hsa-mir-450a-2_L09 J1_ES_untr ................................UUUUGCGAUGUGUUCCUAAU................................................................... 1 2 hsa-mir-450a-2_L10 J1_ES_demeth ...............................UUUUUGCGAUGUGUUCCUAAUAU................................................................. 1 2 hsa-mir-450a-2_L11 J1_ES_demeth hsa-mir-451 chr17:24212493-24212604 - UGCCAGGGCACUUGGGAAUGGCAAGGAAACCGUUACCAUUACUGAGUUUAGUAAUGGUAAUGGUUCUCUUGCUAUACCCAGAAAACGUGCC ......((((((((((.((((((((..(((((((((((((((((....)))))))))))))))))..)))))))).))))).....))))) (-50.80) ..........................AAACCGUUACCAUUACUGAGUUUAG........................................ 3 1 hsa-mir-451_L01_M J1_ES_demeth ..........................AAACCGUUACCAUUACUGAGUUU.......................................... 3 1 hsa-mir-451_L02 ES_Dicer-DEL ..........................AAACCGUUACCAUUACUGAGUUU.......................................... 1 1 hsa-mir-451_L03 ES_Dicer ..........................AAACCGUUACCAUUACUGAGUU........................................... 1 1 hsa-mir-451_L04 J1_ES_demeth ..........................AAACCGUUACCAUUACUGAGUUU.......................................... 1 1 hsa-mir-451_L05 J1_ES_demeth ..........................AAACCGUUACCAUUACUGAGUUUA......................................... 1 1 hsa-mir-451_L06 J1_ES_demeth ...........................AACCGUUACCAUUACUGAGUUUAG........................................ 1 1 hsa-mir-451_L07 J1_ES_demeth ..........................AAACCGUUACCAUUACUGAGUUUA......................................... 1 1 hsa-mir-451_L08 ES_Dicer-DEL ..............................CGUUACCAUUACUGAGUUUAGU....................................... 1 1 hsa-mir-451_O01 ES_Dicer-DEL hsa-mir-452 chrX:150878736-150878860 - CUCCUGUCUUAUAAUUGCUAAGCACUUACAACUGUUUGCAGAGGAAACUGAGACUUUGUAACUAUGUCUCAGUCUCAUCUGCAAAGAAGUAAGUGCUUUGCCAAGCUCCU ................((.((((((((((...(.((((((((.((.((((((((...........)))))))).)).)))))))).).)))))))))).))......... (-41.70) .............................AACUGUUUGCAGAGGAAACUGA........................................................... 2 1 hsa-mir-452_L01_M J1_ES_demeth ................................UGUUUGCAGAGGAAACUGAG.......................................................... 1 1 hsa-mir-452_L02 J1_ES_demeth hsa-mir-455 chr9:116011515-116011650 + CUGCGCCCUUCCCUGGCGUGAGGGUAUGUGCCUUUGGACUACAUCGUGGAAGCCAGCACCAUGCAGUCCAUGGGCAUAUACACUUGCCUCAAGGCCUAUGUCAUCGAGGAGCCAC .((.((.((((..(((((((...((((((((((.((((((.(((.(((........))).))).)))))).))))))))))....(((....))).)))))))..)))).)))). (-48.30) ........................UAUGUGCCUUUGGACUACAUCG..................................................................... 6 1 hsa-mir-455_L01_M J1_ES_demeth .......................GUAUGUGCCUUUGGACUACAU....................................................................... 4 1 hsa-mir-455_L02 J1_ES_untr .......................GUAUGUGCCUUUGGACUACAU....................................................................... 3 1 hsa-mir-455_L03 J1_ES_demeth .......................GUAUGUGCCUUUGGACUACAUC...................................................................... 2 1 hsa-mir-455_L04 J1_ES_demeth ........................UAUGUGCCUUUGGACUACAUCGU.................................................................... 2 1 hsa-mir-455_L05 J1_ES_demeth ........................UAUGUGCCUUUGGACUACAUCG..................................................................... 1 1 hsa-mir-455_L06 ES_Dicer ........................UAUGUGCCUUUGGACUACAUCG..................................................................... 1 1 hsa-mir-455_L07 J1_ES_untr .......................GUAUGUGCCUUUGGACUACAUCG..................................................................... 1 1 hsa-mir-455_L08 J1_ES_untr hsa-mir-484 chr16:15644632-15644750 + CGGCCCUGCAGCCUCGUCAGGCUCAGUCCCCUCCCGAUAAACCCCUAAAUAGGGACUUUCCCGGGGGGUGACCCUGGCUUUUUUGGCGAAAACCCCCA .((.......(((..((((((....(((.(((((((..(((.((((....))))..)))..))))))).)))))))))......)))........)). (-34.86) ................UCAGGCUCAGUCCCCUCCCGAU............................................................ 45 1 hsa-mir-484_L01_M J1_ES_demeth ................UCAGGCUCAGUCCCCUCCCGAU............................................................ 18 1 hsa-mir-484_L02 J1_ES_untr ................UCAGGCUCAGUCCCCUCCCGAU............................................................ 10 1 hsa-mir-484_L03 ES_Dicer ................UCAGGCUCAGUCCCCUCCCGAUA........................................................... 8 1 hsa-mir-484_L04 J1_ES_demeth ................UCAGGCUCAGUCCCCUCCCGA............................................................. 3 1 hsa-mir-484_L05 J1_ES_demeth ................UCAGGCUCAGUCCCCUCCCGAUA........................................................... 2 1 hsa-mir-484_L06 ES_Dicer ................UCAGGCUCAGUCCCCUCCCGA............................................................. 2 1 hsa-mir-484_L07 ES_Dicer ................UCAGGCUCAGUCCCCUCCCGAUA........................................................... 2 1 hsa-mir-484_L08 J1_ES_untr ................UCAGGCUCAGUCCCCUCCC............................................................... 1 1 hsa-mir-484_L09 ES_Dicer ...............GUCAGGCUCAGUCCCCUCCCGAU............................................................ 1 1 hsa-mir-484_L10 ES_Dicer ................UCAGGCUCAGUCCCCUCCCGAUAA.......................................................... 1 1 hsa-mir-484_L11 J1_ES_untr ................UCAGGCUCAGUCCCCUCCCGAUAA.......................................................... 1 1 hsa-mir-484_L12 J1_ES_demeth ................UCAGGCUCAGUCCCCUCCCGAUAAA......................................................... 1 1 hsa-mir-484_L13 J1_ES_demeth ...............GUCAGGCUCAGUCCCCUCCCGAUA........................................................... 1 1 hsa-mir-484_L14 J1_ES_demeth ...................GGCUCAGUCCCCUCCCGA............................................................. 1 1 hsa-mir-484_L15 J1_ES_demeth hsa-mir-485 chr14:100591489-100591601 + CCAGUGUUCAUGUGUGGUACUUGGAGAGAGGCUGGCCGUGAUGAAUUCGAUUCAUCAAAGCGAGUCAUACACGGCUCUCCUCUCUUUUAGUGUCAAAUUCU ..............((..(((..((((((((..(((((((((((.((((...........)))))))).)))))))..))))))))..)))..))...... (-39.70) ..............................................................AGUCAUACACGGCUCUCCUCUCU................ 214 1 hsa-mir-485_R01_M J1_ES_untr ..............................................................AGUCAUACACGGCUCUCCUCUCU................ 191 1 hsa-mir-485_R02 J1_ES_demeth ..............................................................AGUCAUACACGGCUCUCCUCUCU................ 39 1 hsa-mir-485_R03 ES_Dicer ...............................................................GUCAUACACGGCUCUCCUCUCU................ 31 1 hsa-mir-485_R04 J1_ES_untr ..............................................................AGUCAUACACGGCUCUCCUCU.................. 28 1 hsa-mir-485_R05 J1_ES_demeth ..............................................................AGUCAUACACGGCUCUCCUCUC................. 23 1 hsa-mir-485_R06 J1_ES_demeth ...............................................................GUCAUACACGGCUCUCCUCUCU................ 17 1 hsa-mir-485_R07 J1_ES_demeth ..............................................................AGUCAUACACGGCUCUCCUCUC................. 15 1 hsa-mir-485_R08 J1_ES_untr ..............................................................AGUCAUACACGGCUCUCCUCU.................. 9 1 hsa-mir-485_R09 J1_ES_untr ...............................................................GUCAUACACGGCUCUCCUCUCU................ 6 1 hsa-mir-485_R10 ES_Dicer ..............................................................AGUCAUACACGGCUCUCCUCUC................. 4 1 hsa-mir-485_R11 ES_Dicer ...............................................................GUCAUACACGGCUCUCCUCUC................. 3 1 hsa-mir-485_R12 J1_ES_untr ..............................................................AGUCAUACACGGCUCUCCU.................... 3 1 hsa-mir-485_R13 J1_ES_demeth .............................................................GAGUCAUACACGGCUCUCCUCU.................. 3 1 hsa-mir-485_R14 J1_ES_demeth ...............................................................GUCAUACACGGCUCUCCUCU.................. 2 1 hsa-mir-485_R15 ES_Dicer ...............................................................GUCAUACACGGCUCUCCUCUCUU............... 2 1 hsa-mir-485_R16 J1_ES_untr ..............................................................AGUCAUACACGGCUCUCCUCUCUU............... 2 1 hsa-mir-485_R17 J1_ES_untr .................................................................CAUACACGGCUCUCCUCUCUUU.............. 2 1 hsa-mir-485_R18 J1_ES_demeth ..............................................................AGUCAUACACGGCUCUCCUC................... 2 1 hsa-mir-485_R19 J1_ES_demeth ..............................................................AGUCAUACACGGCUCUCCUCUCUU............... 2 1 hsa-mir-485_R20 J1_ES_demeth ..............................................................AGUCAUACACGGCUCUCCUCUCUUU.............. 1 1 hsa-mir-485_R21 ES_Dicer ................................................................UCAUACACGGCUCUCCUCUCU................ 1 1 hsa-mir-485_R22 ES_Dicer ...............................................................GUCAUACACGGCUCUCCUC................... 1 1 hsa-mir-485_R23 ES_Dicer ..............................................................AGUCAUACACGGCUCUCCUCU.................. 1 1 hsa-mir-485_R24 ES_Dicer .............................................................GAGUCAUACACGGCUCUCCUCU.................. 1 1 hsa-mir-485_R25 J1_ES_untr .............................................................GAGUCAUACACGGCUCUCCUCUCU................ 1 1 hsa-mir-485_R26 J1_ES_demeth ....................................................................ACACGGCUCUCCUCUCUU............... 1 1 hsa-mir-485_R27 J1_ES_demeth .................................................................CAUACACGGCUCUCCUCUCUU............... 1 1 hsa-mir-485_R28 J1_ES_demeth ...............................................................GUCAUACACGGCUCUCCUCUCUUU.............. 1 1 hsa-mir-485_R29 J1_ES_demeth hsa-mir-487b chr14:100582525-100582648 + UGCUAACCUUUGGUACUUGGAGAGUGGUUAUCCCUGUCCUGUUCGUUUUGCUCAUGUCGAAUCGUACAGGGUCAUCCACUUUUUCAGUAUCAAGAGCGCAGAC .(((....(((((((((..((((((((....((((((.(.(((((............))))).).))))))....))))))))..))))))))))))...... (-38.40) ...........................................................AAUCGUACAGGGUCAUCCACUU...................... 42 1 hsa-mir-487b_R01_M J1_ES_demeth ...........................................................AAUCGUACAGGGUCAUCCACUU...................... 22 1 hsa-mir-487b_R02 J1_ES_untr ...........................................................AAUCGUACAGGGUCAUCCACUUU..................... 9 1 hsa-mir-487b_R03 J1_ES_demeth ...........................................................AAUCGUACAGGGUCAUCCACUUU..................... 7 1 hsa-mir-487b_R04 J1_ES_untr ............................................................AUCGUACAGGGUCAUCCACUUU..................... 7 1 hsa-mir-487b_R05 J1_ES_untr ...........................................................AAUCGUACAGGGUCAUCCACU....................... 5 1 hsa-mir-487b_R06 J1_ES_demeth ............................................................AUCGUACAGGGUCAUCCACUUU..................... 5 1 hsa-mir-487b_R07 J1_ES_demeth ............................................................AUCGUACAGGGUCAUCCACUU...................... 5 1 hsa-mir-487b_R08 J1_ES_untr ...........................................................AAUCGUACAGGGUCAUCCACU....................... 2 1 hsa-mir-487b_R09 J1_ES_untr hsa-mir-493 chr14:100405130-100405258 + GGGCUCAUUCUGGCCUCCAGGGCUUUGUACAUGGUAGGCUUUCAUUCAUUCGUUUGCACAUUCGGUGAAGGUCUACUGUGUGCCAGGCCCUGUGCCAGGCAUCGUGUA ..((.(((((((((...((((((((.((((((((((((((((((((.....((....))....)))))))))))))))))))).)))))))).)))))).)).).)). (-49.50) ........................UUGUACAUGGUAGGCUUUCAUU.............................................................. 18 1 hsa-mir-493_L01_M J1_ES_demeth ........................UUGUACAUGGUAGGCUUUCAUU.............................................................. 17 1 hsa-mir-493_L02 J1_ES_untr ........................UUGUACAUGGUAGGCUUUCAU............................................................... 7 1 hsa-mir-493_L03 J1_ES_untr ........................UUGUACAUGGUAGGCUUUCAU............................................................... 6 1 hsa-mir-493_L04 J1_ES_demeth ........................UUGUACAUGGUAGGCUUUCA................................................................ 3 1 hsa-mir-493_L05 J1_ES_demeth hsa-mir-494 chr14:100565704-100565824 + CUAAUCUUCGAUACUCGAAGGAGAGGUUGUCCGUGUUGUCUUCUCUUUAUUUAUGAUGAAACAUACACGGGAAACCUCUUUUUUAGUAUCAAAUCCCACC .........((((((.((((((((((((..(((((((((.(((((.........)).)))))).))))))..)))))))))))))))))).......... (-36.10) .......................AGGUUGUCCGUGUUGUCUUCUC....................................................... 2 1 hsa-mir-494_L01*_M J1_ES_untr ....................GAGAGGUUGUCCGUGUUGUCUUC......................................................... 1 1 hsa-mir-494_L02* J1_ES_untr ........................................................UGAAACAUACACGGGAAACCUCU..................... 922 1 hsa-mir-494_R01_M J1_ES_untr ........................................................UGAAACAUACACGGGAAACCUCU..................... 477 1 hsa-mir-494_R02 J1_ES_demeth ........................................................UGAAACAUACACGGGAAACCUCU..................... 118 1 hsa-mir-494_R03 ES_Dicer ........................................................UGAAACAUACACGGGAAACCUC...................... 39 1 hsa-mir-494_R04 J1_ES_untr ........................................................UGAAACAUACACGGGAAACCUC...................... 25 1 hsa-mir-494_R05 J1_ES_demeth ........................................................UGAAACAUACACGGGAAACCUC...................... 20 1 hsa-mir-494_R06 ES_Dicer ........................................................UGAAACAUACACGGGAAACCU....................... 12 1 hsa-mir-494_R07 J1_ES_demeth ........................................................UGAAACAUACACGGGAAACCU....................... 11 1 hsa-mir-494_R08 ES_Dicer ........................................................UGAAACAUACACGGGAAACCU....................... 10 1 hsa-mir-494_R09 J1_ES_untr ........................................................UGAAACAUACACGGGAAACCUCUU.................... 7 1 hsa-mir-494_R10 J1_ES_demeth .......................................................AUGAAACAUACACGGGAAACCUC...................... 4 1 hsa-mir-494_R11 J1_ES_demeth ........................................................UGAAACAUACACGGGAAACCUCUUU................... 1 1 hsa-mir-494_R12 ES_Dicer ........................................................UGAAACAUACACGGGAAACC........................ 1 1 hsa-mir-494_R13 ES_Dicer ........................................................UGAAACAUACACGGGAAACCUCUU.................... 1 1 hsa-mir-494_R14 J1_ES_untr ...........................................................AACAUACACGGGAAACCUCUU.................... 1 1 hsa-mir-494_R15 J1_ES_demeth ........................................................UGAAACAUACACGGGAAACCUCUUU................... 1 1 hsa-mir-494_R16 J1_ES_demeth .........................................................GAAACAUACACGGGAAACCUCU..................... 1 1 hsa-mir-494_R17 J1_ES_demeth hsa-mir-495 chr14:100569825-100569946 + GUGCUCAUCUCUGGUACCUGAAAAGAAGUUGCCCAUGUUAUUUUCGCUUUAUAUGUGACGAAACAAACAUGGUGCACUUCUUUUUCGGUAUCAAAUAUCUCCU ...........(((((((.((((((((((.(((((((((..((((((.........).)))))..))))))).)))))))))))).))))))).......... (-36.40) ............................................................AAACAAACAUGGUGCACUUCUU..................... 564 1 hsa-mir-495_R01_M J1_ES_untr ............................................................AAACAAACAUGGUGCACUUCUU..................... 515 1 hsa-mir-495_R02 J1_ES_demeth ............................................................AAACAAACAUGGUGCACUUCUUU.................... 107 1 hsa-mir-495_R03 J1_ES_untr ............................................................AAACAAACAUGGUGCACUUCUUU.................... 80 1 hsa-mir-495_R04 J1_ES_demeth ............................................................AAACAAACAUGGUGCACUUCU...................... 54 1 hsa-mir-495_R05 J1_ES_untr ............................................................AAACAAACAUGGUGCACUUCU...................... 47 1 hsa-mir-495_R06 J1_ES_demeth ............................................................AAACAAACAUGGUGCACUUCUU..................... 24 1 hsa-mir-495_R07 ES_Dicer .............................................................AACAAACAUGGUGCACUUCUUU.................... 22 1 hsa-mir-495_R08 J1_ES_untr .............................................................AACAAACAUGGUGCACUUCUU..................... 19 1 hsa-mir-495_R09 J1_ES_untr .............................................................AACAAACAUGGUGCACUUCUU..................... 17 1 hsa-mir-495_R10 J1_ES_demeth .............................................................AACAAACAUGGUGCACUUCUUU.................... 16 1 hsa-mir-495_R11 J1_ES_demeth ............................................................AAACAAACAUGGUGCACUUCUUU.................... 9 1 hsa-mir-495_R12 ES_Dicer ............................................................AAACAAACAUGGUGCACUUCU...................... 8 1 hsa-mir-495_R13 ES_Dicer ............................................................AAACAAACAUGGUGCACUUCUUUU................... 7 1 hsa-mir-495_R14 J1_ES_untr ............................................................AAACAAACAUGGUGCACUUCUUUU................... 5 1 hsa-mir-495_R15 J1_ES_demeth .............................................................AACAAACAUGGUGCACUUCU...................... 4 1 hsa-mir-495_R16 J1_ES_demeth ............................................................AAACAAACAUGGUGCACUUC....................... 4 1 hsa-mir-495_R17 J1_ES_demeth .............................................................AACAAACAUGGUGCACUUCU...................... 1 1 hsa-mir-495_R18 ES_Dicer .............................................................AACAAACAUGGUGCACUUCUU..................... 1 1 hsa-mir-495_R19 ES_Dicer ..............................................................ACAAACAUGGUGCACUUCUUU.................... 1 1 hsa-mir-495_R20 J1_ES_untr .............................................................AACAAACAUGGUGCACUUCU...................... 1 1 hsa-mir-495_R21 J1_ES_untr ...........................................................GAAACAAACAUGGUGCACUUCUU..................... 1 1 hsa-mir-495_R22 J1_ES_untr ...............................................................CAAACAUGGUGCACUUCUU..................... 1 1 hsa-mir-495_R23 J1_ES_demeth ................................................................AAACAUGGUGCACUUCUU..................... 1 1 hsa-mir-495_R24 J1_ES_demeth .............................................................AACAAACAUGGUGCACUUCUUUU................... 1 1 hsa-mir-495_R25 J1_ES_demeth hsa-mir-496 chr14:100596643-100596784 + AAGCGAGCACCCAAGUCAGGUACUCGAAUGGAGGUUGUCCAUGGUGUGUUCAUUUUAUUUAUGAUGAGUAUUACAUGGCCAAUCUCCUUUCGGUACUCAAUUCUUCUUGGGAAACGUCACG ..(((....((((((...(((((.((((.((((((((.(((((..(((((((((........)))))))))..))))).)))))))).)))))))))........))))))...))).... (-45.20) ................................................................UGAGUAUUACAUGGCCAAUCUC................................... 11 1 hsa-mir-496_R01_M J1_ES_untr ..................................................................AGUAUUACAUGGCCAAUCUCC.................................. 10 1 hsa-mir-496_R02 J1_ES_untr ................................................................UGAGUAUUACAUGGCCAAUCUC................................... 10 1 hsa-mir-496_R03 J1_ES_demeth ..................................................................AGUAUUACAUGGCCAAUCUCC.................................. 5 1 hsa-mir-496_R04 ES_Dicer ..................................................................AGUAUUACAUGGCCAAUCUCC.................................. 4 1 hsa-mir-496_R05 J1_ES_demeth ................................................................UGAGUAUUACAUGGCCAAUCU.................................... 3 1 hsa-mir-496_R06 J1_ES_untr ................................................................UGAGUAUUACAUGGCCAAUCUCC.................................. 3 1 hsa-mir-496_R07 J1_ES_untr ................................................................UGAGUAUUACAUGGCCAAUCU.................................... 3 1 hsa-mir-496_R08 J1_ES_demeth ................................................................UGAGUAUUACAUGGCCAAUC..................................... 3 1 hsa-mir-496_R09 J1_ES_demeth ..................................................................AGUAUUACAUGGCCAAUCUC................................... 2 1 hsa-mir-496_R10 J1_ES_demeth ..................................................................AGUAUUACAUGGCCAAUCUCCU................................. 1 1 hsa-mir-496_R11 ES_Dicer ................................................................UGAGUAUUACAUGGCCAAUCU.................................... 1 1 hsa-mir-496_R12 ES_Dicer ..................................................................AGUAUUACAUGGCCAAUCU.................................... 1 1 hsa-mir-496_R13 J1_ES_untr ................................................................UGAGUAUUACAUGGCCAAUCUCC.................................. 1 1 hsa-mir-496_R14 J1_ES_demeth hsa-mir-497 chr17:6861934-6862085 - UCCUUUCAACCCACCCCGGUCCUGCUCCCGCCCCAGCAGCACACUGUGGUUUGUACGGCACUGUGGCCACGUCCAAACCACACUGUGGUGUUAGAGCGAGGGUGGGGGAGGCACCGCCGAGGCUUGGCCCU .....((((.((.(..(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....).)))))))))))).))))..).)).)))).... (-59.10) .................................CAGCAGCACACUGUGGUUUGUA............................................................................ 67 1 hsa-mir-497_L01_M J1_ES_untr .................................CAGCAGCACACUGUGGUUUGUA............................................................................ 58 1 hsa-mir-497_L02 J1_ES_demeth .................................CAGCAGCACACUGUGGUUUGU............................................................................. 22 1 hsa-mir-497_L03 J1_ES_untr .................................CAGCAGCACACUGUGGUUUGU............................................................................. 21 1 hsa-mir-497_L04 J1_ES_demeth .................................CAGCAGCACACUGUGGUUUGUA............................................................................ 14 1 hsa-mir-497_L05 ES_Dicer ..................................AGCAGCACACUGUGGUUUGUAC........................................................................... 3 1 hsa-mir-497_L06 J1_ES_untr .................................CAGCAGCACACUGUGGUUUG.............................................................................. 2 1 hsa-mir-497_L07 ES_Dicer .................................CAGCAGCACACUGUGGUUUGU............................................................................. 2 1 hsa-mir-497_L08 ES_Dicer .................................CAGCAGCACACUGUGGUUUGUAC........................................................................... 2 1 hsa-mir-497_L09 J1_ES_untr ...................................GCAGCACACUGUGGUUUGUA............................................................................ 2 1 hsa-mir-497_L10 J1_ES_untr ..................................AGCAGCACACUGUGGUUUGUAC........................................................................... 2 1 hsa-mir-497_L11 J1_ES_demeth .................................CAGCAGCACACUGUGGUUUGUAC........................................................................... 2 1 hsa-mir-497_L12 J1_ES_demeth ..................................AGCAGCACACUGUGGUUUGUAC........................................................................... 1 1 hsa-mir-497_L13 ES_Dicer ..................................AGCAGCACACUGUGGUUUGU............................................................................. 1 1 hsa-mir-497_L14 J1_ES_untr ........................................................................CCAAACCACACUGUGGUGUUA...................................... 1 1 hsa-mir-497_R01*_M ES_Dicer hsa-mir-499 chr20:33041820-33041981 + UCCUUCACCCCCUGCCCUGUCCCCUGUGCCUUGGGCGGGCGGCUGUUAAGACUUGCAGUGAUGUUUAACUCCUCUCCACGUGAACAUCACAGCAAGUCUGUGCUGCUUCCCGUCCCUACGCUGCCUGGGCAGGGUUUGUGGGGAA .......(((((.(((((((((.....((...(((((((.(((.((..((((((((.((((((((((.............)))))))))).))))))))..)).))).)))).)))...)).....)))))))))..).)))).. (-71.82) .............................................UUAAGACUUGCAGUGAUGUUUA.............................................................................. 4 1 hsa-mir-499_L01_M J1_ES_untr .............................................UUAAGACUUGCAGUGAUGUUUA.............................................................................. 3 1 hsa-mir-499_L02 J1_ES_demeth .............................................UUAAGACUUGCAGUGAUGUUUA.............................................................................. 2 1 hsa-mir-499_L03 ES_Dicer .............................................UUAAGACUUGCAGUGAUGUUU............................................................................... 2 1 hsa-mir-499_L04 J1_ES_untr .............................................UUAAGACUUGCAGUGAUGUUU............................................................................... 1 1 hsa-mir-499_L05 ES_Dicer .............................................UUAAGACUUGCAGUGAUGUUU............................................................................... 1 1 hsa-mir-499_L06 J1_ES_demeth .................................................................................GAACAUCACAGCAAGUCUG............................................. 1 1 hsa-mir-499_R01*_M ES_Dicer hsa-mir-501 chrX:49661050-49661173 + UUCUGCUCUGCUCUUCCUCUCUAAUCCUUUGUCCCUGGGUGAGAGUGCUUUCUGAAUGCAAUGCACCCGGGCAAGGAUUCUGAGAGGGUGAGCCCCCUCUGCGUG ....((...((((.(((((((.(((((((.(.(((.(((((....(((.........)))...))))))))))))))))..))))))).)))).......))... (-44.40) ......................AAUCCUUUGUCCCUGGGUGA............................................................... 2 1 hsa-mir-501_L01_M J1_ES_demeth hsa-mir-532 chrX:49654474-49654604 + CAGACCUCCCGACUUGCUUUCUCUCCUCCAUGCCUUGAGUGUAGGACCGUUGGCAUCUUAAUUACCCUCCCACACCCAAGGCUUGCAAAAAAGCGAGCCUUCUCUUCCCU ..........(.((((((((........((.((((((.((((.(((..((.............))..))).)))).)))))).))....)))))))).)........... (-25.72) ............................CAUGCCUUGAGUGUAGGACCGU............................................................ 26 1 hsa-mir-532_L01_M J1_ES_untr ............................CAUGCCUUGAGUGUAGGACCGU............................................................ 24 1 hsa-mir-532_L02 J1_ES_demeth ............................CAUGCCUUGAGUGUAGGACCGU............................................................ 10 1 hsa-mir-532_L03 ES_Dicer ............................CAUGCCUUGAGUGUAGGACCG............................................................. 2 1 hsa-mir-532_L04 J1_ES_demeth ............................CAUGCCUUGAGUGUAGGACCGUU........................................................... 1 1 hsa-mir-532_L05 J1_ES_untr ............................CAUGCCUUGAGUGUAGGACC.............................................................. 1 1 hsa-mir-532_L06 J1_ES_demeth ............................CAUGCCUUGAGUGUAGGACCGUU........................................................... 1 1 hsa-mir-532_L07 J1_ES_demeth hsa-mir-539 chr14:100583391-100583508 + GUCCGUGCUGCUGUUUCAUACUUGAGGAGAAAUUAUCCUUGGUGUGUUCGCUUUAUUUAUGAUGAAUCAUACAAGGACAAUUUCUUUUUGAGUAUCAAAUCUUGC .........((.((((.(((((..((((((((((.((((((.(((((((((.........).)))).)))))))))).))))))))))..))))).))))...)) (-31.90) .........................GGAGAAAUUAUCCUUGGUGUGUU......................................................... 30 1 hsa-mir-539_L01_M J1_ES_untr .........................GGAGAAAUUAUCCUUGGUGUGUU......................................................... 30 1 hsa-mir-539_L02 J1_ES_demeth .........................GGAGAAAUUAUCCUUGGUGUGU.......................................................... 12 1 hsa-mir-539_L03 J1_ES_untr .........................GGAGAAAUUAUCCUUGGUGUGU.......................................................... 12 1 hsa-mir-539_L04 J1_ES_demeth ..........................GAGAAAUUAUCCUUGGUGUGUU......................................................... 11 1 hsa-mir-539_L05 J1_ES_demeth ..........................GAGAAAUUAUCCUUGGUGUGU.......................................................... 5 1 hsa-mir-539_L06 J1_ES_demeth .........................GGAGAAAUUAUCCUUGGUGUGUU......................................................... 1 1 hsa-mir-539_L07 ES_Dicer ..........................GAGAAAUUAUCCUUGGUGUGUU......................................................... 1 1 hsa-mir-539_L08 ES_Dicer hsa-mir-542 chrX:133503017-133503153 - CAAGGAUGCACAGAUCUCAGACAUCUCGGGGAUCAUCAUGUCACGAGAUACCAGUGUGCACUUGUGACAGAUUGAUAACUGAAAGGUCUGGGAGCCACUCAUCUUCAUAGCAAAAC ..((((((......((((((((...((((..((((...(((((((((.(((....)))..)))))))))...))))..))))...))))))))......))))))........... (-41.20) ........................CUCGGGGAUCAUCAUGUCACGA...................................................................... 4 1 hsa-mir-542_L01*_M J1_ES_demeth ........................CUCGGGGAUCAUCAUGUCACGAGA.................................................................... 1 1 hsa-mir-542_L02* J1_ES_demeth ..............................................................UGUGACAGAUUGAUAACUGAAAG............................... 15 1 hsa-mir-542_R01_M J1_ES_demeth ..............................................................UGUGACAGAUUGAUAACUGAAAG............................... 12 1 hsa-mir-542_R02 J1_ES_untr ..............................................................UGUGACAGAUUGAUAACUGAAA................................ 10 1 hsa-mir-542_R03 J1_ES_untr ..............................................................UGUGACAGAUUGAUAACUGAAAG............................... 5 1 hsa-mir-542_R04 ES_Dicer ..............................................................UGUGACAGAUUGAUAACUGAAA................................ 5 1 hsa-mir-542_R05 J1_ES_demeth ..............................................................UGUGACAGAUUGAUAACUGAA................................. 4 1 hsa-mir-542_R06 J1_ES_demeth ..............................................................UGUGACAGAUUGAUAACUGAAA................................ 2 1 hsa-mir-542_R07 ES_Dicer ..............................................................UGUGACAGAUUGAUAACUGA.................................. 1 1 hsa-mir-542_R08 ES_Dicer ..............................................................UGUGACAGAUUGAUAACUGA.................................. 1 1 hsa-mir-542_R09 J1_ES_demeth hsa-mir-543 chr14:100568057-100568174 + GACGUGCGGUACUUAAUGAGAAGUUGCCCGUGUUUUUUUCGCUUUAUUUGUGACGAAACAUUCGCGGUGCACUUCUUUUUCAGUAUCCUAUUCUGCC ((.(((.((((((.((.(((((((.(((((((.((((.((((.......)))).))))....))))).))))))))).)).)))))).))))).... (-30.00) .......................................................AAACAUUCGCGGUGCACUUCUU.................... 1382 1 hsa-mir-543_R01_M J1_ES_untr .......................................................AAACAUUCGCGGUGCACUUCUU.................... 1025 1 hsa-mir-543_R02 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUCUUU................... 338 1 hsa-mir-543_R03 J1_ES_untr .......................................................AAACAUUCGCGGUGCACUUCUUU................... 274 1 hsa-mir-543_R04 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUCU..................... 173 1 hsa-mir-543_R05 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUCU..................... 139 1 hsa-mir-543_R06 J1_ES_untr ........................................................AACAUUCGCGGUGCACUUCUU.................... 32 1 hsa-mir-543_R07 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUCUUUU.................. 22 1 hsa-mir-543_R08 J1_ES_untr .......................................................AAACAUUCGCGGUGCACUUCU..................... 17 1 hsa-mir-543_R09 ES_Dicer .......................................................AAACAUUCGCGGUGCACUUCUU.................... 15 1 hsa-mir-543_R10 ES_Dicer .......................................................AAACAUUCGCGGUGCACUUCUUUU.................. 13 1 hsa-mir-543_R11 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUC...................... 13 1 hsa-mir-543_R12 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUCUUU................... 9 1 hsa-mir-543_R13 ES_Dicer ........................................................AACAUUCGCGGUGCACUUCUU.................... 7 1 hsa-mir-543_R14 J1_ES_untr ........................................................AACAUUCGCGGUGCACUUCU..................... 5 1 hsa-mir-543_R15 J1_ES_demeth ........................................................AACAUUCGCGGUGCACUUCUUU................... 5 1 hsa-mir-543_R16 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUUC...................... 3 1 hsa-mir-543_R17 ES_Dicer .......................................................AAACAUUCGCGGUGCACUUC...................... 3 1 hsa-mir-543_R18 J1_ES_untr .....................................................CGAAACAUUCGCGGUGCACUUCU..................... 3 1 hsa-mir-543_R19 J1_ES_demeth .......................................................AAACAUUCGCGGUGCACUU....................... 3 1 hsa-mir-543_R20 J1_ES_demeth ......................................................GAAACAUUCGCGGUGCACUUCUU.................... 3 1 hsa-mir-543_R21 J1_ES_demeth .....................................................CGAAACAUUCGCGGUGCACUUC...................... 2 1 hsa-mir-543_R22 J1_ES_untr ........................................................AACAUUCGCGGUGCACUUCUU.................... 1 1 hsa-mir-543_R23 ES_Dicer ........................................................AACAUUCGCGGUGCACUUCUUU................... 1 1 hsa-mir-543_R24 J1_ES_untr ......................................................GAAACAUUCGCGGUGCACUUCUU.................... 1 1 hsa-mir-543_R25 J1_ES_untr .......................................................AAACAUUCGCGGUGCACUU....................... 1 1 hsa-mir-543_R26 J1_ES_untr ........................................................AACAUUCGCGGUGCACUU....................... 1 1 hsa-mir-543_R27 J1_ES_untr ...........................................................AUUCGCGGUGCACUUCUU.................... 1 1 hsa-mir-543_R28 J1_ES_untr .......................................................AAACAUUCGCGGUGCACUUCUUUUU................. 1 1 hsa-mir-543_R29 J1_ES_demeth ......................................................GAAACAUUCGCGGUGCACUUCU..................... 1 1 hsa-mir-543_R30 J1_ES_demeth ........................................................AACAUUCGCGGUGCACUU....................... 1 1 hsa-mir-543_R31 J1_ES_demeth .........................................................ACAUUCGCGGUGCACUUCUU.................... 1 1 hsa-mir-543_R32 J1_ES_demeth ...........................................................AUUCGCGGUGCACUUCUUU................... 1 1 hsa-mir-543_R33 J1_ES_demeth .....................................................CGAAACAUUCGCGGUGCACUUC...................... 1 1 hsa-mir-543_R34 J1_ES_demeth hsa-mir-558 chr2:32610704-32610837 + UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUUAUUUUGGUAUAGUAGCUCUAGACUCUAUUAUAGUUUCCUGAGCUGCUGUACCAAAAUACCACAAACGGGCUGGCUUAAAACA ........(((...((.((..((.(((.((((((.((((((((((((((((((..((..(((...)))..))..)))))))))))))))))))))))).))).))..)).))..))) (-46.80) UGUGUGUGUGUGUGUGUGU.................................................................................................. 2 1 hsa-mir-558_L01_M J1_ES_demeth .GUGUGUGUGUGUGUGUGUGUGUG............................................................................................. 1 1 hsa-mir-558_L02 ES_Dicer-DEL UGUGUGUGUGUGUGUGUGUGUGUG............................................................................................. 1 1 hsa-mir-558_L03 J1_ES_untr .GUGUGUGUGUGUGUGUGU.................................................................................................. 1 1 hsa-mir-558_L04 J1_ES_demeth hsa-mir-574 chr4:38546028-38546163 + GGCGCGGCCGAGGGACCUGCGUGGGUGCGGGCGUGUGAGUGUGUGUGUGUGAGUGUGUGUCGCUCCGGGUCCACGCUCAUGCACACACCCACACGCCCACACUCAGGGUCUGCCCCC ((.(.(((....((((((...((((((.(((((((((.(.(((((((((((((((((..((......))..))))))))))))))))))))))))))).)))))))))))))))))) (-72.70) .......................................................................CACGCUCAUGCACACACCCACA........................ 2 1 hsa-mir-574_R01_M J1_ES_demeth .......................................................................CACGCUCAUGCACACACCCACA........................ 2 1 hsa-mir-574_R02 J1_ES_untr .......................................................................CACGCUCAUGCACACACCCAC......................... 1 1 hsa-mir-574_R03 J1_ES_demeth hsa-mir-582 chr5:59035169-59035306 - CAACAAGUCAAUCUGUGCUCUUUGAUUACAGUUGUUCAACCAGUUACUAAUCUAACUAAUUGUAACUGGUUGAACAACUGAACCCAAAGGGUGCAAAGUAGAAACAUUUCAUUGUGA ..((((.......((..(((((((....(((((((((((((((((((..............)))))))))))))))))))....)))))))..)).....(((....))).)))).. (-45.34) ..........................UACAGUUGUUCAACCAGUUACU..................................................................... 3 1 hsa-mir-582_L01_M J1_ES_demeth ..........................UACAGUUGUUCAACCAGUUACU..................................................................... 3 1 hsa-mir-582_L02 J1_ES_untr ..........................UACAGUUGUUCAACCAGUUAC...................................................................... 2 1 hsa-mir-582_L03 J1_ES_untr ...........................ACAGUUGUUCAACCAGUUACU..................................................................... 2 1 hsa-mir-582_L04 J1_ES_untr hsa-mir-592 chr7:126485358-126485494 - AAUUUGAUGAUAUUAUGCCAUGACAUUGUGUCAAUAUGCGAUGAUGUGUUGUGAUGGCACAGCGUCAUCACGUGGUGACGCAACAUCAUGACGUAAGACGUCACAACGCCAGUUAA ....(((((...(((((.(((((..((((((((.((((.((((((((..((((....)))))))))))).)))).))))))))..))))).)))))..)))))............. (-43.30) ................................................................UCAUCACGUGGUGACGCAACAU.............................. 1 1 hsa-mir-592_R01_M J1_ES_untr hsa-mir-636 chr17:72244107-72244245 - CGGCGAGAUAAUGGCGGCCUGGGCGGGAGCGCGCGGGCGGGGCCGGCCCCGCUGCCUGGAAUUAACCCCGCUGUGCUUGCUCGUCCCGCCCGCAGCCCUAGGCGGCGUCGCCGCAGCCG ((((.......(((.(((.(((((((((((((((((.((((((((((......))).))......)))))))))))..))...)))))))))..)))))).(((((...))))).)))) (-63.60) ............................GCGCGCGGGCGGGGCCGG......................................................................... 1 1 hsa-mir-636_L01_M ES_Dicer-DEL hsa-mir-652 chrX:109185193-109185330 + AGGGCCGCCACGAAUGGCUAUGCACUGCACAACCCUAGGAGAGGGUGCCAUUCACAUAGACUAUAAUUGAAUGGCGCCACUAGGGUUGUGCAGUGCACAACCUACACAACUGUACUC (((...((((....))))..((((((((((((((((((.....(((((((((((..((.....))..))))))))))).))))))))))))))))))...))).............. (-61.30) .....................................................................AAUGGCGCCACUAGGGUUGU............................ 2 1 hsa-mir-652_R01_M ES_Dicer .....................................................................AAUGGCGCCACUAGGGUUGUG........................... 2 1 hsa-mir-652_R02 J1_ES_untr .....................................................................AAUGGCGCCACUAGGGUUGU............................ 2 1 hsa-mir-652_R03 J1_ES_demeth .....................................................................AAUGGCGCCACUAGGGUUGUG........................... 1 1 hsa-mir-652_R04 J1_ES_demeth hsa-mir-653 chr7:92949988-92950123 - GAGGUUCUAAUUUUUCAUUCCUUCAGUGUUGAAACAAUCUCUACUGAACCAGCUUCAAACAAGUUCACUGGAGUUUGUUUCAAUAUUGCAAGAAUGAUAAGAUGGAAGCUACUUUCAU .((.(((((.(((.((((((...((((((((((((((.(((((.(((((.............))))).))))).))))))))))))))...)))))).))).))))).))........ (-40.92) ............................UUGAAACAAUCUCUACUGAACC.................................................................... 4 1 hsa-mir-653_L01_M J1_ES_untr ............................UUGAAACAAUCUCUACUGAACC.................................................................... 1 1 hsa-mir-653_L02 J1_ES_demeth ............................UUGAAACAAUCUCUACUGAA...................................................................... 1 1 hsa-mir-653_L03 J1_ES_untr hsa-mir-671 chr7:150566420-150566577 + GCCCGGCUGGCAGGUGAACUGGCAGGCCAGGAAGAGGAGGAAGCCCUGGAGGGGCUGGAGGUGAUGGAUGUUUUCCUCCGGUUCUCAGGGCUCCACCUCUUUCGGGCCGUAGAGCCAGGGCUGGUGCAGAAGUUCUC (((((((((.(((.....))).).((((.((((((((.(((.((((((..(((((((((((.(((....)))..)))))))))))))))))))).)))))))).))))....)))).))))................ (-75.10) .....................................AGGAAGCCCUGGAGGGGCUGGAGGUGA......................................................................... 1 1 hsa-mir-671_L01_M J1_ES_demeth hsa-mir-7-1 chr9:85774463-85774612 - AGAAGAUUCAUUGGAUGUUGGCCUAGUUCUGUGUGGAAGACUAGUGAUUUUGUUGUUUUUAGAUAACUAAAUCGACAACAAAUCACAGUCUGCCAUAUGGCACAGGCCAUGCCUCUACAGGACAAAUGAU ......(((..((((.((((((((.((.((((((((.(((((.(((((((.(((((((((((....)))))..)))))))))))))))))).)))))))).)))))))).)).))))..)))........ (-48.60) .................................UGGAAGACUAGUGAUUUUGUUGUU......................................................................... 134 3 hsa-mir-7-1_L01_M J1_ES_demeth .................................UGGAAGACUAGUGAUUUUGUUGU.......................................................................... 71 3 hsa-mir-7-1_L02 J1_ES_untr .................................UGGAAGACUAGUGAUUUUGUUGU.......................................................................... 59 3 hsa-mir-7-1_L03 J1_ES_demeth .................................UGGAAGACUAGUGAUUUUGUUGUU......................................................................... 58 3 hsa-mir-7-1_L04 J1_ES_untr .................................UGGAAGACUAGUGAUUUUGUUG........................................................................... 31 3 hsa-mir-7-1_L05 J1_ES_demeth .................................UGGAAGACUAGUGAUUUUGUUG........................................................................... 15 3 hsa-mir-7-1_L06 J1_ES_untr .................................UGGAAGACUAGUGAUUUUGUU............................................................................ 12 3 hsa-mir-7-1_L07 J1_ES_demeth .................................UGGAAGACUAGUGAUUUUGUUGU.......................................................................... 11 3 hsa-mir-7-1_L08 ES_Dicer .................................UGGAAGACUAGUGAUUUUGUUGUUU........................................................................ 5 1 hsa-mir-7-1_L09 J1_ES_demeth .................................UGGAAGACUAGUGAUUUUGUUGUU......................................................................... 3 3 hsa-mir-7-1_L10 ES_Dicer .................................UGGAAGACUAGUGAUUUUGUUG........................................................................... 3 3 hsa-mir-7-1_L11 ES_Dicer .................................UGGAAGACUAGUGAUUUUGU............................................................................. 2 3 hsa-mir-7-1_L12 J1_ES_untr .................................UGGAAGACUAGUGAUUUUGUUGUUU........................................................................ 2 1 hsa-mir-7-1_L13 J1_ES_untr .................................UGGAAGACUAGUGAUUUUGUU............................................................................ 2 3 hsa-mir-7-1_L14 J1_ES_untr .................................UGGAAGACUAGUGAUUUUGU............................................................................. 2 3 hsa-mir-7-1_L15 J1_ES_demeth ....................................AAGACUAGUGAUUUUGUUGUU......................................................................... 2 3 hsa-mir-7-1_L16 J1_ES_demeth .....................................AGACUAGUGAUUUUGUUGUU......................................................................... 2 3 hsa-mir-7-1_L17 J1_ES_demeth ...........................................................................CAACAAAUCACAGUCUGCCAUA................................. 37 1 hsa-mir-7-1_R01*_M J1_ES_demeth ...........................................................................CAACAAAUCACAGUCUGCCAUA................................. 25 1 hsa-mir-7-1_R02* J1_ES_untr ...........................................................................CAACAAAUCACAGUCUGCCAU.................................. 14 1 hsa-mir-7-1_R03* J1_ES_demeth ...........................................................................CAACAAAUCACAGUCUGCCAU.................................. 8 1 hsa-mir-7-1_R04* J1_ES_untr ...........................................................................CAACAAAUCACAGUCUGCCAUAU................................ 3 1 hsa-mir-7-1_R05* J1_ES_untr ............................................................................AACAAAUCACAGUCUGCCAUA................................. 3 1 hsa-mir-7-1_R06* J1_ES_demeth ...........................................................................CAACAAAUCACAGUCUGCCAUAU................................ 2 1 hsa-mir-7-1_R07* J1_ES_demeth ............................................................................AACAAAUCACAGUCUGCCAUA................................. 1 1 hsa-mir-7-1_R08* J1_ES_untr hsa-mir-7-2 chr15:86956040-86956189 + AGAACUGGCCUGGAUACAGAGUGGACCGGCUGGCCCCAUCUGGAAGACUAGUGAUUUUGUUGUUGUCUUACUGCGCUCAACAACAAAUCCCAGUCUACCUAAUGGUGCCAGCCAUCGCAGCGGGGUGCAGGAAAU ....(((((((.(.......((((...(((((((.((((..((.(((((.(.(((((.(((((((............))))))))))))).))))).))..)))).))))))).))))..).)))).)))..... (-51.90) ........................................UGGAAGACUAGUGAUUUUGUUGUU....................................................................... 134 3 hsa-mir-7-2_L01_M J1_ES_demeth ........................................UGGAAGACUAGUGAUUUUGUUGU........................................................................ 71 3 hsa-mir-7-2_L02 J1_ES_untr ........................................UGGAAGACUAGUGAUUUUGUUGU........................................................................ 59 3 hsa-mir-7-2_L03 J1_ES_demeth ........................................UGGAAGACUAGUGAUUUUGUUGUU....................................................................... 58 3 hsa-mir-7-2_L04 J1_ES_untr ........................................UGGAAGACUAGUGAUUUUGUUG......................................................................... 31 3 hsa-mir-7-2_L05 J1_ES_demeth ........................................UGGAAGACUAGUGAUUUUGUUG......................................................................... 15 3 hsa-mir-7-2_L06 J1_ES_untr ........................................UGGAAGACUAGUGAUUUUGUU.......................................................................... 12 3 hsa-mir-7-2_L07 J1_ES_demeth ........................................UGGAAGACUAGUGAUUUUGUUGU........................................................................ 11 3 hsa-mir-7-2_L08 ES_Dicer ........................................UGGAAGACUAGUGAUUUUGUUGUU....................................................................... 3 3 hsa-mir-7-2_L09 ES_Dicer ........................................UGGAAGACUAGUGAUUUUGUUG......................................................................... 3 3 hsa-mir-7-2_L10 ES_Dicer ........................................UGGAAGACUAGUGAUUUUGU........................................................................... 2 3 hsa-mir-7-2_L11 J1_ES_untr ........................................UGGAAGACUAGUGAUUUUGUU.......................................................................... 2 3 hsa-mir-7-2_L12 J1_ES_untr ............................................AGACUAGUGAUUUUGUUGUU....................................................................... 2 3 hsa-mir-7-2_L13 J1_ES_demeth ........................................UGGAAGACUAGUGAUUUUGU........................................................................... 2 3 hsa-mir-7-2_L14 J1_ES_demeth ...........................................AAGACUAGUGAUUUUGUUGUU....................................................................... 2 3 hsa-mir-7-2_L15 J1_ES_demeth hsa-mir-7-3 chr19:4721662-4721811 + UGGUGAAGAAGAUUAGAGUGGCUGUGGUCUAGUGCUGUGUGGAAGACUAGUGAUUUUGUUGUUCUGAUGUACUACGACAACAAGUCACAGCCGGCCUCAUAGCGCAGACUCCCUUCGACCUUCGCCUUC .(((((((....(..(((.((....(((((.((((((((.((..(.((.(((((((.((((((.((......)).))))))))))))))).)..)).))))))))))))))))))..).)))))))... (-48.50) .......................................UGGAAGACUAGUGAUUUUGUUGUU.................................................................. 134 3 hsa-mir-7-3_L01_M J1_ES_demeth .......................................UGGAAGACUAGUGAUUUUGUUGU................................................................... 71 3 hsa-mir-7-3_L02 J1_ES_untr .......................................UGGAAGACUAGUGAUUUUGUUGU................................................................... 59 3 hsa-mir-7-3_L03 J1_ES_demeth .......................................UGGAAGACUAGUGAUUUUGUUGUU.................................................................. 58 3 hsa-mir-7-3_L04 J1_ES_untr .......................................UGGAAGACUAGUGAUUUUGUUG.................................................................... 31 3 hsa-mir-7-3_L05 J1_ES_demeth .......................................UGGAAGACUAGUGAUUUUGUUG.................................................................... 15 3 hsa-mir-7-3_L06 J1_ES_untr .......................................UGGAAGACUAGUGAUUUUGUU..................................................................... 12 3 hsa-mir-7-3_L07 J1_ES_demeth .......................................UGGAAGACUAGUGAUUUUGUUGU................................................................... 11 3 hsa-mir-7-3_L08 ES_Dicer .......................................UGGAAGACUAGUGAUUUUGUUGUU.................................................................. 3 3 hsa-mir-7-3_L09 ES_Dicer .......................................UGGAAGACUAGUGAUUUUGUUG.................................................................... 3 3 hsa-mir-7-3_L10 ES_Dicer .......................................UGGAAGACUAGUGAUUUUGU...................................................................... 2 3 hsa-mir-7-3_L11 J1_ES_untr .......................................UGGAAGACUAGUGAUUUUGUU..................................................................... 2 3 hsa-mir-7-3_L12 J1_ES_untr ...........................................AGACUAGUGAUUUUGUUGUU.................................................................. 2 3 hsa-mir-7-3_L13 J1_ES_demeth .......................................UGGAAGACUAGUGAUUUUGU...................................................................... 2 3 hsa-mir-7-3_L14 J1_ES_demeth ..........................................AAGACUAGUGAUUUUGUUGUU.................................................................. 2 3 hsa-mir-7-3_L15 J1_ES_demeth hsa-mir-708 chr11:78790694-78790821 - GUGAAAUGGUAACUGCCCUCAAGGAGCUUACAAUCUAGCUGGGGGUAAAUGACUUGCACAUGAACACAACUAGACUGUGAGCUUCUAGAGGGCAGGGACCUUACCCU ((((...(((..((((((((.(((((((((((.(((((.((...((..(((.......)))..)).)).))))).))))))))))).))))))))..)))))))... (-50.30) ....................AAGGAGCUUACAAUCUAGCUGGG................................................................ 15 1 hsa-mir-708_L01_M J1_ES_untr ....................AAGGAGCUUACAAUCUAGCUGGG................................................................ 13 1 hsa-mir-708_L02 J1_ES_demeth ....................AAGGAGCUUACAAUCUAGCUGGG................................................................ 3 1 hsa-mir-708_L03 ES_Dicer ....................AAGGAGCUUACAAUCUAGCUG.................................................................. 1 1 hsa-mir-708_L04 J1_ES_untr ....................AAGGAGCUUACAAUCUAGCUGG................................................................. 1 1 hsa-mir-708_L05 J1_ES_untr ....................AAGGAGCUUACAAUCUAGCUGG................................................................. 1 1 hsa-mir-708_L06 J1_ES_demeth .....................AGGAGCUUACAAUCUAGCUGG................................................................. 1 1 hsa-mir-708_L07 J1_ES_demeth .....................AGGAGCUUACAAUCUAGCUGGG................................................................ 1 1 hsa-mir-708_L08 J1_ES_demeth ...................................................................AACUAGACUGUGAGCUUCUAGA.................. 3 1 hsa-mir-708_R01*_M J1_ES_demeth ...................................................................AACUAGACUGUGAGCUUCU..................... 2 1 hsa-mir-708_R02* ES_Dicer ..................................................................CAACUAGACUGUGAGCUUCUAGA.................. 2 1 hsa-mir-708_R03* J1_ES_demeth ....................................................................ACUAGACUGUGAGCUUCUAGA.................. 1 1 hsa-mir-708_R04* ES_Dicer ..................................................................CAACUAGACUGUGAGCUUCUA.................... 1 1 hsa-mir-708_R05* J1_ES_untr ...................................................................AACUAGACUGUGAGCUUCUAGA.................. 1 1 hsa-mir-708_R06* J1_ES_untr ..................................................................CAACUAGACUGUGAGCUUCUA.................... 1 1 hsa-mir-708_R07* J1_ES_demeth ..................................................................CAACUAGACUGUGAGCUUCUAG................... 1 1 hsa-mir-708_R08* J1_ES_demeth hsa-mir-720 chr3:165541803-165541952 + GGAGCGAGACCGGAUCUCACACGGUGGUGUUAAUAUCUCGCUGGGGCCUCCAAAAUGUUGUGCCCAGGGGUGUUAGAGAAAACACCACACUUUGAGAUGAAUUAAGAGUCCUUUAUUAGCCGGCGACCG ((..((...((((.(((((....((((((((((((((((....(((((..(.....)..).)))).)))))))))......)))))))....)))))..(((.(((....))).)))..)))))).)). (-39.50) ..................................AUCUCGCUGGGGCCUCCA............................................................................. 3 1 hsa-mir-720_L01_M ES_Dicer-DEL hsa-mir-744 chr17:11925921-11926058 + CACACUGGGUUGGGCAAGGUGCGGGGCUAGGGCUAACAGCAGUCUUACUGAAGGUUUCCUGGAAACCACGCACAUGCUGUUGCCACUAACCUCAACCUUACUCGGUCCUGACCGGCU ......((..((((.(((((..((((.((((((.(((((((.((.....)).((((((...)))))).......)))))))))).))).)))).))))).))))..))......... (-44.90) ...................UGCGGGGCUAGGGCUAACAGCA............................................................................ 45 1 hsa-mir-744_L01_M J1_ES_demeth ...................UGCGGGGCUAGGGCUAACAGCA............................................................................ 10 1 hsa-mir-744_L02 J1_ES_untr ...................UGCGGGGCUAGGGCUAACAGC............................................................................. 10 1 hsa-mir-744_L03 J1_ES_demeth ...................UGCGGGGCUAGGGCUAACAGCA............................................................................ 7 1 hsa-mir-744_L04 ES_Dicer ...................UGCGGGGCUAGGGCUAACAGC............................................................................. 4 1 hsa-mir-744_L05 ES_Dicer ...................UGCGGGGCUAGGGCUAACAG.............................................................................. 4 1 hsa-mir-744_L06 J1_ES_demeth ...................UGCGGGGCUAGGGCUAACAGC............................................................................. 2 1 hsa-mir-744_L07 J1_ES_untr ...................UGCGGGGCUAGGGCUAACAGCAG........................................................................... 1 1 hsa-mir-744_L08 ES_Dicer ............................................................................CUGUUGCCACUAACCUCAACC.................... 5 1 hsa-mir-744_R01*_M J1_ES_untr ............................................................................CUGUUGCCACUAACCUCAACC.................... 3 1 hsa-mir-744_R02* J1_ES_demeth ............................................................................CUGUUGCCACUAACCUCAACCU................... 2 1 hsa-mir-744_R03* J1_ES_demeth ............................................................................CUGUUGCCACUAACCUCAA...................... 1 1 hsa-mir-744_R04* ES_Dicer ............................................................................CUGUUGCCACUAACCUCAACCU................... 1 1 hsa-mir-744_R05* J1_ES_untr hsa-mir-758 chr14:100562090-100562217 + UCAGCACGUGCCUGGAUACAUGAGAUGGUUGACCAGAGAGCACACGCUUUAUUUGUGCCGUUUGUGACCUGGUCCACUAACCCUCAGUAUCUAAUGCCCCCUUGGAG ((((...(.((.(((((((.((((.((((.((((((...(((.((((.........).))).)))...)))))).))))...)))))))))))..)))...)))).. (-30.70) .........................UGGUUGACCAGAGAGCACACG............................................................. 2 1 hsa-mir-758_L01*_M J1_ES_untr ............................................................UUUGUGACCUGGUCCACUAACC......................... 19 1 hsa-mir-758_R01_M J1_ES_demeth ............................................................UUUGUGACCUGGUCCACUAACC......................... 18 1 hsa-mir-758_R02 J1_ES_untr ............................................................UUUGUGACCUGGUCCACUAACCC........................ 9 1 hsa-mir-758_R03 J1_ES_untr ............................................................UUUGUGACCUGGUCCACUAAC.......................... 8 1 hsa-mir-758_R04 J1_ES_untr ............................................................UUUGUGACCUGGUCCACUAAC.......................... 6 1 hsa-mir-758_R05 J1_ES_demeth ............................................................UUUGUGACCUGGUCCACUAA........................... 3 1 hsa-mir-758_R06 J1_ES_demeth ............................................................UUUGUGACCUGGUCCACUAACCC........................ 3 1 hsa-mir-758_R07 J1_ES_demeth ............................................................UUUGUGACCUGGUCCACUAAC.......................... 1 1 hsa-mir-758_R08 ES_Dicer ............................................................UUUGUGACCUGGUCCACUAA........................... 1 1 hsa-mir-758_R09 J1_ES_untr .............................................................UUGUGACCUGGUCCACUAAC.......................... 1 1 hsa-mir-758_R10 J1_ES_demeth hsa-mir-874 chr5:137011140-137011257 - AUUGUUGGUGUUAGCCCUGCGGCCCCACGCACCAGGGUAAGAGAGACUCUCGCUUCCUGCCCUGGCCCGAGGGACCGACUGGCUGGGCCUGCCUUCU ...((.(((.((((((...(((.(((.((..((((((((.(((.(.....)..))).))))))))..)).))).)))...))))))))).))..... (-41.60) ........................................................CUGCCCUGGCCCGAGGGACCGAC.................. 1 1 hsa-mir-874_R01_M J1_ES_untr hsa-mir-877 chr6:30660068-30660193 + UGCUGAGAGGCUAGAGAAGGUAGAGGAGAUGGCGCAGGGGACACGGGCAAAGACUUGGGGGUUCCUGGGACCCUCAGACGUGUGUCCUCUUCUCCCUCCUCCCAGGUGUAUGAGGAAUUGCGGGC .(((....))).......((..((((((..((.(.((((((((((.(.......(((((((((.....))))))))).).)))))))))).).))))))))))...((((........))))... (-46.20) ...................GUAGAGGAGAUGGCGCAGGGGACA.................................................................................. 1 1 hsa-mir-877_L01_M J1_ES_untr hsa-mir-9-1 chr1:154656737-154656865 - AGCCAGGAGGCGGGGUUGGUUGUUAUCUUUGGUUAUCUAGCUGUAUGAGUGGUGUGGAGUCUUCAUAAAGCUAGAUAACCGAAAGUAAAAAUAACCCCAUACACUGCG .(((....)))(((((((....(((..(((((((((((((((.((((((.((.......)))))))).)))))))))))))))..)))...))))))).......... (-44.50) .........................UCUUUGGUUAUCUAGCUGUAUGA............................................................ 48 3 hsa-mir-9-1_L01_M J1_ES_demeth .........................UCUUUGGUUAUCUAGCUGUAUGA............................................................ 20 3 hsa-mir-9-1_L02 J1_ES_untr .........................UCUUUGGUUAUCUAGCUGUAUG............................................................. 9 3 hsa-mir-9-1_L03 J1_ES_demeth .........................UCUUUGGUUAUCUAGCUGUAUG............................................................. 5 3 hsa-mir-9-1_L04 J1_ES_untr .........................UCUUUGGUUAUCUAGCUGUAUGA............................................................ 3 3 hsa-mir-9-1_L05 ES_Dicer .........................UCUUUGGUUAUCUAGCUGUAU.............................................................. 2 3 hsa-mir-9-1_L06 J1_ES_demeth .........................UCUUUGGUUAUCUAGCUGUAUG............................................................. 1 3 hsa-mir-9-1_L07 ES_Dicer ..........................CUUUGGUUAUCUAGCUGUAUGA............................................................ 1 3 hsa-mir-9-1_L08 ES_Dicer .........................UCUUUGGUUAUCUAGCUGUAU.............................................................. 1 3 hsa-mir-9-1_L09 J1_ES_untr ..........................CUUUGGUUAUCUAGCUGUAUGA............................................................ 1 3 hsa-mir-9-1_L10 J1_ES_demeth ................................................................AUAAAGCUAGAUAACCGAAAGUA..................... 3 3 hsa-mir-9-1_R01*_M J1_ES_demeth .................................................................UAAAGCUAGAUAACCGAAAGUA..................... 3 3 hsa-mir-9-1_R02* J1_ES_demeth ................................................................AUAAAGCUAGAUAACCGAAAGU...................... 2 3 hsa-mir-9-1_R03* ES_Dicer .................................................................UAAAGCUAGAUAACCGAAAGUA..................... 1 3 hsa-mir-9-1_R04* ES_Dicer ................................................................AUAAAGCUAGAUAACCGAAAGU...................... 1 3 hsa-mir-9-1_R05* J1_ES_demeth .................................................................UAAAGCUAGAUAACCGAAAGUAA.................... 1 2 hsa-mir-9-1_R06* J1_ES_demeth hsa-mir-9-2 chr5:87998407-87998533 - GGCCUGUGUGGGAAGCGAGUUGUUAUCUUUGGUUAUCUAGCUGUAUGAGUGUAUUGGUCUUCAUAAAGCUAGAUAACCGAAAGUAAAAACUCCUUCAAGAUCGCCG (((..((.(..((((.(((((.(((..(((((((((((((((.((((((..(....)..)))))).)))))))))))))))..))).))))))))).).)).))). (-44.40) .........................UCUUUGGUUAUCUAGCUGUAUGA.......................................................... 48 3 hsa-mir-9-2_L01_M J1_ES_demeth .........................UCUUUGGUUAUCUAGCUGUAUGA.......................................................... 20 3 hsa-mir-9-2_L02 J1_ES_untr .........................UCUUUGGUUAUCUAGCUGUAUG........................................................... 9 3 hsa-mir-9-2_L03 J1_ES_demeth .........................UCUUUGGUUAUCUAGCUGUAUG........................................................... 5 3 hsa-mir-9-2_L04 J1_ES_untr .........................UCUUUGGUUAUCUAGCUGUAUGA.......................................................... 3 3 hsa-mir-9-2_L05 ES_Dicer .........................UCUUUGGUUAUCUAGCUGUAU............................................................ 2 3 hsa-mir-9-2_L06 J1_ES_demeth .........................UCUUUGGUUAUCUAGCUGUAUG........................................................... 1 3 hsa-mir-9-2_L07 ES_Dicer ..........................CUUUGGUUAUCUAGCUGUAUGA.......................................................... 1 3 hsa-mir-9-2_L08 ES_Dicer .........................UCUUUGGUUAUCUAGCUGUAU............................................................ 1 3 hsa-mir-9-2_L09 J1_ES_untr ..........................CUUUGGUUAUCUAGCUGUAUGA.......................................................... 1 3 hsa-mir-9-2_L10 J1_ES_demeth ..............................................................AUAAAGCUAGAUAACCGAAAGUA..................... 3 3 hsa-mir-9-2_R01*_M J1_ES_demeth ...............................................................UAAAGCUAGAUAACCGAAAGUA..................... 3 3 hsa-mir-9-2_R02* J1_ES_demeth ..............................................................AUAAAGCUAGAUAACCGAAAGU...................... 2 3 hsa-mir-9-2_R03* ES_Dicer ...............................................................UAAAGCUAGAUAACCGAAAGUA..................... 1 3 hsa-mir-9-2_R04* ES_Dicer ..............................................................AUAAAGCUAGAUAACCGAAAGU...................... 1 3 hsa-mir-9-2_R05* J1_ES_demeth ...............................................................UAAAGCUAGAUAACCGAAAGUAA.................... 1 2 hsa-mir-9-2_R06* J1_ES_demeth hsa-mir-9-3 chr15:87712232-87712361 + CUGGCUAAGGGAGGCCCGUUUCUCUCUUUGGUUAUCUAGCUGUAUGAGUGCCACAGAGCCGUCAUAAAGCUAGAUAACCGAAAGUAGAAAUGAUUCUCACAACUUCUGC ...((.(((.((((..(((((((((.(((((((((((((((.(((((..((......))..))))).))))))))))))))))).)))))))..))))....)))..)) (-42.60) ........................UCUUUGGUUAUCUAGCUGUAUGA.............................................................. 48 3 hsa-mir-9-3_L01_M J1_ES_demeth ........................UCUUUGGUUAUCUAGCUGUAUGA.............................................................. 20 3 hsa-mir-9-3_L02 J1_ES_untr ........................UCUUUGGUUAUCUAGCUGUAUG............................................................... 9 3 hsa-mir-9-3_L03 J1_ES_demeth ........................UCUUUGGUUAUCUAGCUGUAUG............................................................... 5 3 hsa-mir-9-3_L04 J1_ES_untr ........................UCUUUGGUUAUCUAGCUGUAUGA.............................................................. 3 3 hsa-mir-9-3_L05 ES_Dicer ........................UCUUUGGUUAUCUAGCUGUAU................................................................ 2 3 hsa-mir-9-3_L06 J1_ES_demeth ........................UCUUUGGUUAUCUAGCUGUAUG............................................................... 1 3 hsa-mir-9-3_L07 ES_Dicer .........................CUUUGGUUAUCUAGCUGUAUGA.............................................................. 1 3 hsa-mir-9-3_L08 ES_Dicer ........................UCUUUGGUUAUCUAGCUGUAU................................................................ 1 3 hsa-mir-9-3_L09 J1_ES_untr .........................CUUUGGUUAUCUAGCUGUAUGA.............................................................. 1 3 hsa-mir-9-3_L10 J1_ES_demeth ...............................................................AUAAAGCUAGAUAACCGAAAGUA....................... 3 3 hsa-mir-9-3_R01*_M J1_ES_demeth ................................................................UAAAGCUAGAUAACCGAAAGUA....................... 3 3 hsa-mir-9-3_R02* J1_ES_demeth ...............................................................AUAAAGCUAGAUAACCGAAAGU........................ 2 3 hsa-mir-9-3_R03* ES_Dicer ................................................................UAAAGCUAGAUAACCGAAAGUA....................... 1 3 hsa-mir-9-3_R04* ES_Dicer ...............................................................AUAAAGCUAGAUAACCGAAAGU........................ 1 3 hsa-mir-9-3_R05* J1_ES_demeth hsa-mir-923 chr17:30502272-30502366 - AAUUUAAGCAUAUUUGUCAGCGGAGGAAAAGAAACUAACCAGGAUUCCCUCAGUAAUGGCGAGUGAACAGGGAA ..........(((((((((((.((((....(((.((.....)).))))))).))..)))))))))......... (-14.10) .....................GGAGGAAAAGAAACUAACCAGGAUUCCCUCA...................... 2 1 hsa-mir-923_L01_M J1_ES_demeth .....................GGAGGAAAAGAAACUAACCA................................. 2 1 hsa-mir-923_L02 J1_ES_untr .....................GGAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_L03 J1_ES_demeth ...............GUCAGCGGAGGAAAAGAA......................................... 1 1 hsa-mir-923_L04 J1_ES_demeth ...................GCGGAGGAAAAGAAACUAAC................................... 1 1 hsa-mir-923_L05 J1_ES_demeth ....................CGGAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_L06 J1_ES_demeth .................CAGCGGAGGAAAAGAAACU...................................... 1 1 hsa-mir-923_L07 J1_ES_demeth .................CAGCGGAGGAAAAGAAACUAA.................................... 1 1 hsa-mir-923_L08 J1_ES_untr ....................CGGAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_L09 J1_ES_untr ...................GCGGAGGAAAAGAAACUAACCAG................................ 1 1 hsa-mir-923_L10 J1_ES_untr ...................GCGGAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_L11 J1_ES_untr ..........................AAAAGAAACUAACCAGGAUUCCCUCAG..................... 6 1 hsa-mir-923_O01 J1_ES_untr ...................................UAACCAGGAUUCCCUCAG..................... 5 1 hsa-mir-923_O02 J1_ES_demeth ..................................CUAACCAGGAUUCCCUCAG..................... 4 1 hsa-mir-923_O03 ES_Dicer-DEL .......................AGGAAAAGAAACUAACCAGGAUUCCCUC....................... 3 1 hsa-mir-923_O04 J1_ES_untr ...............................AAACUAACCAGGAUUCCCUCAG..................... 3 1 hsa-mir-923_O05 J1_ES_untr ..............................GAAACUAACCAGGAUUCCCUCA...................... 3 1 hsa-mir-923_O06 J1_ES_untr ..................................CUAACCAGGAUUCCCUCAG..................... 2 1 hsa-mir-923_O07 ES_Dicer ..............................GAAACUAACCAGGAUUCCCUCAG..................... 2 1 hsa-mir-923_O08 J1_ES_demeth .......................AGGAAAAGAAACUAACCAGGAUUCCCUCA...................... 2 1 hsa-mir-923_O09 J1_ES_untr .................................ACUAACCAGGAUUCCCUCAG..................... 2 1 hsa-mir-923_O10 ES_Dicer-DEL ...................................UAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O11 ES_Dicer .......................AGGAAAAGAAACUAACCAGGAUUCCCUC....................... 1 1 hsa-mir-923_O12 J1_ES_demeth .............................AGAAACUAACCAGGAUUCCCUC....................... 1 1 hsa-mir-923_O13 J1_ES_demeth .......................AGGAAAAGAAACUAACCAGGAUUCCCUCA...................... 1 1 hsa-mir-923_O14 J1_ES_demeth .................................ACUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O15 J1_ES_demeth ...............................AAACUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O16 J1_ES_demeth ......................GAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_O17 J1_ES_demeth ..................................CUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O18 J1_ES_demeth ...........................AAAGAAACUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O19 J1_ES_untr ..............................GAAACUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O20 J1_ES_untr .............................AGAAACUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O21 J1_ES_untr .......................AGGAAAAGAAACUAACCAGGAUUCCC......................... 1 1 hsa-mir-923_O22 J1_ES_untr ......................GAGGAAAAGAAACUAACCA................................. 1 1 hsa-mir-923_O23 ES_Dicer-DEL ......................GAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_O24 ES_Dicer-DEL ...................................UAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O25 ES_Dicer-DEL hsa-mir-92a-1 chr13:90801549-90801666 + CUCAAACCCCUUUCUACACAGGUUGGGAUCGGUUGCAAUGCUGUGUUUCUGUAUGGUAUUGCACUUGUCCCGGCCUGUUGAGUUUGGUGGGGAUUGU ..(((.((((...((..((((((((((((.(((.(((((((((((......)))))))))))))).))))))))))))..))......)))).))). (-45.00) ........................................................UAUUGCACUUGUCCCGGCCUGU................... 847 2 hsa-mir-92a-1_R01_M J1_ES_untr ........................................................UAUUGCACUUGUCCCGGCCUGU................... 671 2 hsa-mir-92a-1_R02 ES_Dicer ........................................................UAUUGCACUUGUCCCGGCCUGU................... 606 2 hsa-mir-92a-1_R03 J1_ES_demeth ........................................................UAUUGCACUUGUCCCGGCCUG.................... 73 2 hsa-mir-92a-1_R04 ES_Dicer ........................................................UAUUGCACUUGUCCCGGCCUG.................... 29 2 hsa-mir-92a-1_R05 J1_ES_untr ........................................................UAUUGCACUUGUCCCGGCCUG.................... 18 2 hsa-mir-92a-1_R06 J1_ES_demeth .........................................................AUUGCACUUGUCCCGGCCUGU................... 12 2 hsa-mir-92a-1_R07 ES_Dicer ........................................................UAUUGCACUUGUCCCGGCCUGUU.................. 12 1 hsa-mir-92a-1_R08 J1_ES_untr ........................................................UAUUGCACUUGUCCCGGCCUGUU.................. 10 1 hsa-mir-92a-1_R09 J1_ES_demeth .........................................................AUUGCACUUGUCCCGGCCUG.................... 8 2 hsa-mir-92a-1_R10 ES_Dicer .........................................................AUUGCACUUGUCCCGGCCUGU................... 8 2 hsa-mir-92a-1_R11 J1_ES_untr .........................................................AUUGCACUUGUCCCGGCCUGU................... 8 2 hsa-mir-92a-1_R12 J1_ES_demeth ........................................................UAUUGCACUUGUCCCGGCCU..................... 6 2 hsa-mir-92a-1_R13 ES_Dicer .......................................................GUAUUGCACUUGUCCCGGCCUGU................... 4 2 hsa-mir-92a-1_R14 ES_Dicer ........................................................UAUUGCACUUGUCCCGGCCUGUU.................. 4 1 hsa-mir-92a-1_R15 ES_Dicer .......................................................GUAUUGCACUUGUCCCGGCCUGU................... 3 2 hsa-mir-92a-1_R16 J1_ES_untr ..........................................................UUGCACUUGUCCCGGCCUGU................... 2 2 hsa-mir-92a-1_R17 ES_Dicer ..........................................................UUGCACUUGUCCCGGCCUGU................... 2 2 hsa-mir-92a-1_R18 J1_ES_demeth ..........................................................UUGCACUUGUCCCGGCCUGU................... 1 2 hsa-mir-92a-1_R19 J1_ES_untr ........................................................UAUUGCACUUGUCCCGGCCU..................... 1 2 hsa-mir-92a-1_R20 J1_ES_untr ........................................................UAUUGCACUUGUCCCGGCCU..................... 1 2 hsa-mir-92a-1_R21 J1_ES_demeth .........................................................AUUGCACUUGUCCCGGCCUG.................... 1 2 hsa-mir-92a-1_R22 J1_ES_demeth .......................................................GUAUUGCACUUGUCCCGGCCUGU................... 1 2 hsa-mir-92a-1_R23 J1_ES_demeth hsa-mir-92a-2 chrX:133131214-133131328 - UCAUGCCCAUUCAUCCCUGGGUGGGGAUUUGUUGCAUUACUUGUGUUCUAUAUAAAGUAUUGCACUUGUCCCGGCCUGUGGAAGAAAGGAGGAU ......((.(((.(((.(((((.(((((..((.(((.(((((((((...)))).))))).)))))..))))).))))).))).))).))..... (-35.20) .........................................................UAUUGCACUUGUCCCGGCCUGU............... 847 2 hsa-mir-92a-2_R01_M J1_ES_untr .........................................................UAUUGCACUUGUCCCGGCCUGU............... 671 2 hsa-mir-92a-2_R02 ES_Dicer .........................................................UAUUGCACUUGUCCCGGCCUGU............... 606 2 hsa-mir-92a-2_R03 J1_ES_demeth .........................................................UAUUGCACUUGUCCCGGCCUG................ 73 2 hsa-mir-92a-2_R04 ES_Dicer .........................................................UAUUGCACUUGUCCCGGCCUG................ 29 2 hsa-mir-92a-2_R05 J1_ES_untr .........................................................UAUUGCACUUGUCCCGGCCUG................ 18 2 hsa-mir-92a-2_R06 J1_ES_demeth ..........................................................AUUGCACUUGUCCCGGCCUGU............... 12 2 hsa-mir-92a-2_R07 ES_Dicer ..........................................................AUUGCACUUGUCCCGGCCUG................ 8 2 hsa-mir-92a-2_R08 ES_Dicer ..........................................................AUUGCACUUGUCCCGGCCUGU............... 8 2 hsa-mir-92a-2_R09 J1_ES_untr ..........................................................AUUGCACUUGUCCCGGCCUGU............... 8 2 hsa-mir-92a-2_R10 J1_ES_demeth .........................................................UAUUGCACUUGUCCCGGCCU................. 6 2 hsa-mir-92a-2_R11 ES_Dicer ........................................................GUAUUGCACUUGUCCCGGCCUGU............... 4 2 hsa-mir-92a-2_R12 ES_Dicer ........................................................GUAUUGCACUUGUCCCGGCCUGU............... 3 2 hsa-mir-92a-2_R13 J1_ES_untr ...........................................................UUGCACUUGUCCCGGCCUGU............... 2 2 hsa-mir-92a-2_R14 ES_Dicer .........................................................UAUUGCACUUGUCCCGGCCUGUG.............. 2 1 hsa-mir-92a-2_R15 J1_ES_untr ...........................................................UUGCACUUGUCCCGGCCUGU............... 2 2 hsa-mir-92a-2_R16 J1_ES_demeth .........................................................UAUUGCACUUGUCCCGGCCUGUG.............. 1 1 hsa-mir-92a-2_R17 ES_Dicer .......................................................AGUAUUGCACUUGUCCCGGCCU................. 1 1 hsa-mir-92a-2_R18 ES_Dicer .......................................................AGUAUUGCACUUGUCCCGGCCUGU............... 1 1 hsa-mir-92a-2_R19 ES_Dicer ...........................................................UUGCACUUGUCCCGGCCUGU............... 1 2 hsa-mir-92a-2_R20 J1_ES_untr .........................................................UAUUGCACUUGUCCCGGCCU................. 1 2 hsa-mir-92a-2_R21 J1_ES_untr .........................................................UAUUGCACUUGUCCCGGCCU................. 1 2 hsa-mir-92a-2_R22 J1_ES_demeth ..........................................................AUUGCACUUGUCCCGGCCUG................ 1 2 hsa-mir-92a-2_R23 J1_ES_demeth ........................................................GUAUUGCACUUGUCCCGGCCUGU............... 1 2 hsa-mir-92a-2_R24 J1_ES_demeth hsa-mir-92b chr1:153431572-153431707 + AGCGGGAUCCCGGGCCCCGGGCGGGCGGGAGGGACGGGACGCGGUGCAGUGUUGUUUUUUCCCCCGCCAAUAUUGCACUCGUCCCGGCCUCCGGCCCCCCCGGCCCCCCGGCCUCC ....(((..(((((..(((((.((((.(((((..(((((((.((((((((((((.............))))))))))))))))))).))))).)))).)))))...)))))..))) (-74.82) ......................................................................UAUUGCACUCGUCCCGGCCUCC........................ 21 1 hsa-mir-92b_R01_M J1_ES_untr ......................................................................UAUUGCACUCGUCCCGGCCUCC........................ 12 1 hsa-mir-92b_R02 ES_Dicer ......................................................................UAUUGCACUCGUCCCGGCCUCC........................ 10 1 hsa-mir-92b_R03 J1_ES_demeth ......................................................................UAUUGCACUCGUCCCGGCCUC......................... 5 1 hsa-mir-92b_R04 J1_ES_untr ......................................................................UAUUGCACUCGUCCCGGCCUC......................... 5 1 hsa-mir-92b_R05 J1_ES_demeth ......................................................................UAUUGCACUCGUCCCGGCCUC......................... 4 1 hsa-mir-92b_R06 ES_Dicer ......................................................................UAUUGCACUCGUCCCGGCCU.......................... 2 1 hsa-mir-92b_R07 J1_ES_demeth ......................................................................UAUUGCACUCGUCCCGGCC........................... 1 1 hsa-mir-92b_R08 ES_Dicer ......................................................................UAUUGCACUCGUCCCGGCC........................... 1 1 hsa-mir-92b_R09 J1_ES_demeth hsa-mir-93 chr7:99529307-99529426 - GACCUCAGUCCUGGGGGCUCCAAAGUGCUGUUCGUGCAGGUAGUGUGAUUACCCAACCUACUGCUGAGCUAGCACUUCCCGAGCCCCCGGGACACGUUC .......(((((((((((((..((((((((((((.((((.(((..((......))..)))))))))))).)))))))...)))))))))))))...... (-54.60) ....................CAAAGUGCUGUUCGUGCAGGUAG........................................................ 221 1 hsa-mir-93_L01_M J1_ES_untr ....................CAAAGUGCUGUUCGUGCAGGUAG........................................................ 193 1 hsa-mir-93_L02 J1_ES_demeth ....................CAAAGUGCUGUUCGUGCAGGUAG........................................................ 156 1 hsa-mir-93_L03 ES_Dicer ....................CAAAGUGCUGUUCGUGCAGGU.......................................................... 6 1 hsa-mir-93_L04 ES_Dicer ....................CAAAGUGCUGUUCGUGCAGGUA......................................................... 6 1 hsa-mir-93_L05 J1_ES_untr ....................CAAAGUGCUGUUCGUGCAGGUAGU....................................................... 5 1 hsa-mir-93_L06 J1_ES_untr ....................CAAAGUGCUGUUCGUGCAGGUAGU....................................................... 5 1 hsa-mir-93_L07 J1_ES_demeth ....................CAAAGUGCUGUUCGUGCAGGU.......................................................... 5 1 hsa-mir-93_L08 J1_ES_demeth ....................CAAAGUGCUGUUCGUGCAG............................................................ 4 1 hsa-mir-93_L09 ES_Dicer ....................CAAAGUGCUGUUCGUGCAGGUAGU....................................................... 4 1 hsa-mir-93_L10 ES_Dicer ....................CAAAGUGCUGUUCGUGCAGGU.......................................................... 3 1 hsa-mir-93_L11 J1_ES_untr ....................CAAAGUGCUGUUCGUGCAGGUA......................................................... 2 1 hsa-mir-93_L12 ES_Dicer ...................CCAAAGUGCUGUUCGUGCAGGUA......................................................... 1 1 hsa-mir-93_L13 ES_Dicer ......................AAGUGCUGUUCGUGCAGGUAG........................................................ 1 1 hsa-mir-93_L14 ES_Dicer .....................AAAGUGCUGUUCGUGCAGGUAG........................................................ 1 1 hsa-mir-93_L15 J1_ES_untr ........................GUGCUGUUCGUGCAGGUAG........................................................ 1 1 hsa-mir-93_L16 J1_ES_untr ........................GUGCUGUUCGUGCAGGUAG........................................................ 1 1 hsa-mir-93_L17 J1_ES_demeth ....................CAAAGUGCUGUUCGUGCAG............................................................ 1 1 hsa-mir-93_L18 J1_ES_demeth ...........................................................ACUGCUGAGCUAGCACUUCCCGA................. 5 1 hsa-mir-93_R01*_M J1_ES_demeth ...........................................................ACUGCUGAGCUAGCACUUCCCGA................. 4 1 hsa-mir-93_R02* J1_ES_untr ...........................................................ACUGCUGAGCUAGCACUUCC.................... 2 1 hsa-mir-93_R03* ES_Dicer ............................................................CUGCUGAGCUAGCACUUCCCG.................. 1 1 hsa-mir-93_R04* ES_Dicer hsa-mir-935 chr19:59177353-59177483 + CUCAAGGCCGGCGGGGGCGCGGGCGGCAGUGGCGGGAGCGGCCCCUCGGCCAUCCUCCGUCUGCCCAGUUACCGCUUCCGCUACCGCCGCCGCUCCCGCUCUAGCUCCCG .....(((.(((((((((...((((((.(((((((((((((...((.(((............))).))...))))))))))))).)))))))))))))))...))).... (-63.90) .................................................................CAGUUACCGCUUCCGCUACCGC....................... 2 1 hsa-mir-935_R01_M ES_Dicer hsa-mir-96 chr7:129201748-129201865 - GCCAUCUGCUUGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAAAGCAGGACC ....(((((((..((.((.((((((((.((((((..(((((((((......)))...))))))..)))))))))))))).)).))..)))))))... (-46.10) ..................UUUGGCACUAGCACAUUUUUGCU........................................................ 383 1 hsa-mir-96_L01_M J1_ES_demeth ..................UUUGGCACUAGCACAUUUUUGCU........................................................ 137 1 hsa-mir-96_L02 J1_ES_untr ..................UUUGGCACUAGCACAUUUUUGC......................................................... 132 1 hsa-mir-96_L03 J1_ES_demeth ..................UUUGGCACUAGCACAUUUUUGCU........................................................ 67 1 hsa-mir-96_L04 ES_Dicer ..................UUUGGCACUAGCACAUUUUUGC......................................................... 28 1 hsa-mir-96_L05 J1_ES_untr ..................UUUGGCACUAGCACAUUUUUG.......................................................... 15 1 hsa-mir-96_L06 J1_ES_demeth ..................UUUGGCACUAGCACAUUUUUG.......................................................... 8 1 hsa-mir-96_L07 ES_Dicer ..................UUUGGCACUAGCACAUUUUUGC......................................................... 7 1 hsa-mir-96_L08 ES_Dicer ...................UUGGCACUAGCACAUUUUUGCU........................................................ 5 1 hsa-mir-96_L09 J1_ES_demeth ..................UUUGGCACUAGCACAUUUUUGCUU....................................................... 5 1 hsa-mir-96_L10 J1_ES_demeth ...................UUGGCACUAGCACAUUUUUGCU........................................................ 4 1 hsa-mir-96_L11 ES_Dicer ..................UUUGGCACUAGCACAUUUUUG.......................................................... 4 1 hsa-mir-96_L12 J1_ES_untr ..................UUUGGCACUAGCACAUUUU............................................................ 2 1 hsa-mir-96_L13 J1_ES_demeth ..................UUUGGCACUAGCACAUUUUUGCUU....................................................... 2 1 hsa-mir-96_L14 J1_ES_untr .................UUUUGGCACUAGCACAUUUUUGCU........................................................ 2 1 hsa-mir-96_L15 J1_ES_untr ...................UUGGCACUAGCACAUUUUUGCU........................................................ 2 1 hsa-mir-96_L16 J1_ES_untr ..................UUUGGCACUAGCACAUUUUU........................................................... 1 1 hsa-mir-96_L17 ES_Dicer ...................UUGGCACUAGCACAUUUUUGC......................................................... 1 1 hsa-mir-96_L18 J1_ES_untr ..................UUUGGCACUAGCACAUUUUU........................................................... 1 1 hsa-mir-96_L19 ES_Dicer-DEL hsa-mir-98 chrX:53599889-53600047 - CCCUUAUUAGAGGAUUCUGCUCAUGCCAGGGUGAGGUAGUAAGUUGUAUUGUUGUGGGGUAGGGAUAUUAGGCCCCAAUUAGAAGAUAACUAUACAACUUACUACUUUCCCUGGUGUGUGGCAUAUUCACACUUAGUC .((((....))))....((((((((((((((.(((((((((((((((((.((((((((((...........)))))).........)))).))))))))))))))))))))))))))).))))............... (-57.60) ...............................UGAGGUAGUAAGUUGUAUUGUU..................................................................................... 1 1 hsa-mir-98_L01_M J1_ES_demeth ...............................UGAGGUAGUAAGUUGUAUUGUU..................................................................................... 1 1 hsa-mir-98_L02 J1_ES_untr hsa-mir-99a chr21:16833260-16833380 + UGCAAGAUGUUGCCCAUUGGCAUAAACCCGUAGAUCCGAUCUUGUGGUGAAGUGGACCGCACAAGCUCGCUUCUAUGGGUCUGUGUCAGUGUGGUAAUCUGACAAA ((..((((..((((((((((((((.(((((((((..(((.((((((.((........)))))))).)))..))))))))).)))))))))).))))))))..)).. (-48.40) ........................AACCCGUAGAUCCGAUCUUGU............................................................. 1 1 hsa-mir-99a_L01_M J1_ES_demeth ........................AACCCGUAGAUCCGAUCUUGUG............................................................ 1 1 hsa-mir-99a_L02 J1_ES_demeth hsa-mir-99b chr19:56887657-56887766 + CUGGGUCCUGGCACCCACCCGUAGAACCGACCUUGCGGGGCCUUCGCCGCACACAAGCUCGUGUCUGUGGGUCCGUGUCGGGGGCUCAC .(((((((((((((..(((((((((..(((.((((.(((((....))).).).)))).)))..)))))))))..))))).)))))))). (-42.80) ...............CACCCGUAGAACCGACCUUGCG.................................................... 19 1 hsa-mir-99b_L01_M J1_ES_untr ...............CACCCGUAGAACCGACCUUGCG.................................................... 12 1 hsa-mir-99b_L02 J1_ES_demeth ...............CACCCGUAGAACCGACCUUGC..................................................... 6 1 hsa-mir-99b_L03 J1_ES_untr ...............CACCCGUAGAACCGACCUUGC..................................................... 6 1 hsa-mir-99b_L04 J1_ES_demeth ................ACCCGUAGAACCGACCUUGCG.................................................... 2 1 hsa-mir-99b_L05 J1_ES_demeth ..................CCGUAGAACCGACCUUGCG.................................................... 1 1 hsa-mir-99b_L06 ES_Dicer ..................CCGUAGAACCGACCUUGCG.................................................... 1 1 hsa-mir-99b_L07 J1_ES_demeth .....................................................CAAGCUCGUGUCUGUGGGUCCG.............. 5 1 hsa-mir-99b_R01*_M J1_ES_demeth .....................................................CAAGCUCGUGUCUGUGGGUCCGU............. 3 1 hsa-mir-99b_R02* J1_ES_demeth .....................................................CAAGCUCGUGUCUGUGGGUCCG.............. 1 1 hsa-mir-99b_R03* J1_ES_untr .....................................................CAAGCUCGUGUCUGUGGGUCCGU............. 1 1 hsa-mir-99b_R04* J1_ES_untr