hsa-let-7a-1 chr9:95978040-95978159 + UCUUCACUGUGGGAUGAGGUAGUAGGUUGUAUAGUUUUAGGGUCACACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUUUCCUAACGUGAUAGA (((((((..(((((.(((..((((((((((((((((...(((.....))).((....))....))))))))))))))))..))))))))..)))).))) (-42.10) ..............UGAGGUAGUAGGUUGUAUAGUU............................................................... 10 3 hsa-let-7a-1_L01_M ESC_WT_454 ..............UGAGGUAGUAGGUUGUAUAGU................................................................ 4 3 hsa-let-7a-1_L02 ESC_WT_454 .................................................................CUAUACAAUCUACUGUCUUUCC............ 1 2 hsa-let-7a-1_R01*_M ESC_WT_454 hsa-let-7a-2 chr11:121522420-121522531 - GCAUGCUCCCAGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCUUGGGUCUUG .......((((((..(((.(((.(((((((((((((.....(..(.....)..)...))))))))))))).))).)))..))))))..... (-34.40) ..............UGAGGUAGUAGGUUGUAUAGUU....................................................... 10 3 hsa-let-7a-2_L01_M ESC_WT_454 ..............UGAGGUAGUAGGUUGUAUAGU........................................................ 4 3 hsa-let-7a-2_L02 ESC_WT_454 hsa-let-7a-3 chr22:44887273-44887386 + UGCCCUUUGGGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCUGAAGUGGCUG .((((((..(((.(((..((((((((((((((((((((((...)))))).........))))))))))))))))..))))))..))).))).. (-46.00) ............UGAGGUAGUAGGUUGUAUAGUU........................................................... 10 3 hsa-let-7a-3_L01_M ESC_WT_454 ............UGAGGUAGUAGGUUGUAUAGU............................................................ 4 3 hsa-let-7a-3_L02 ESC_WT_454 ............................................................CUAUACAAUCUACUGUCUUUCC........... 1 2 hsa-let-7a-3_R01*_M ESC_WT_454 hsa-let-7b chr22:44888210-44888332 + CGGGCCUGGCGGGGUGAGGUAGUAGGUUGUGUGGUUUCAGGGCAGUGAUGUUGCCCCUCGGAAGAUAACUAUACAACCUACUGCCUUCCCUGAGGAGCCCAG .((((((..(((((.(((((((((((((((((((((...((((((.....)))))).((....)).)))))))))))))))))))))))))).)).)))).. (-63.00) ..............UGAGGUAGUAGGUUGUGUGGUU.................................................................. 6 1 hsa-let-7b_L01_M ESC_WT_454 hsa-let-7c chr21:16833999-16834122 + AAGCUGUGUGCAUCCGGGUUGAGGUAGUAGGUUGUAUGGUUUAGAGUUACACCCUGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUGGAGCACACUUGAGC ..(((((((((.((((((..(((.(((.(((((((((((((..((.(..(.....)..).))))))))))))))).))).)))..))))))))))))...))) (-44.10) ...................UGAGGUAGUAGGUUGUAUGGUU.............................................................. 406 1 hsa-let-7c_L01_M ESC_WT_454 ...................UGAGGUAGUAGGUUGUAUGGU............................................................... 27 1 hsa-let-7c_L02 ESC_WT_454 ...................UGAGGUAGUAGGUUGUAUGGUUU............................................................. 6 1 hsa-let-7c_L03 ESC_WT_454 ...................UGAGGUAGUAGGUUGUAUGGUU.............................................................. 4 1 hsa-let-7c_L04 ESC_DGCR8_454 ....................GAGGUAGUAGGUUGUAUGGUU.............................................................. 2 1 hsa-let-7c_L05 ESC_WT_454 hsa-let-7d chr9:95980917-95981043 + AAAAAAAUGGGUUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUUAU .....((((((..(((((((.((((((((((((((.((((((...((((((.....)))))).(.....)..)))))).)))))))))))))))))))))..)))))).. (-50.20) ....................AGAGGUAGUAGGUUGCAUAGUU.................................................................... 2 1 hsa-let-7d_L01_M ESC_WT_454 hsa-let-7e chr19:56887831-56887949 + GCCGCGCCCCCCGGGCUGAGGUAGGAGGUUGUAUAGUUGAGGAGGACACCCAAGGAGAUCACUAUACGGCCUCCUAGCUUUCCCCAGGCUGCGCCCUG ...((((..((.(((..(((.((((((((((((((((.((...((....)).......)))))))))))))))))).)))..))).))..)))).... (-46.90) ................UGAGGUAGGAGGUUGUAUAGUU............................................................ 11 1 hsa-let-7e_L01_M ESC_WT_454 ................UGAGGUAGGAGGUUGUAUAGU............................................................. 3 1 hsa-let-7e_L02 ESC_WT_454 ................UGAGGUAGGAGGUUGUAUAGUUG........................................................... 2 1 hsa-let-7e_L03 ESC_WT_454 hsa-let-7f-1 chr9:95978430-95978556 + AAAACAUUGCUCUAUCAGAGUGAGGUAGUAGAUUGUAUAGUUGUGGGGUAGUGAUUUUACCCUGUUCAGGAGAUAACUAUACAAUCUAUUGCCUUCCCUGAGGAGUAGACU ......(((((((.((((.(..(((((((((((((((((((((((((((((.....))))))).........))))))))))))))))))))))..))))))))))))... (-51.90) ....................UGAGGUAGUAGAUUGUAUAGUU..................................................................... 17 2 hsa-let-7f-1_L01_M ESC_WT_454 hsa-let-7f-2 chrX:53600858-53600980 - ACUGGUGCUCUGUGGGAUGAGGUAGUAGAUUGUAUAGUUUUAGGGUCAUACCCCAUCUUGGAGAUAACUAUACAGUCUACUGUCUUUCCCACGGUGGUACAC ....(((((((((((((.(((..((((((((((((((((...(((.....))).(((.....)))))))))))))))))))..))))))))))).))))).. (-49.70) .................UGAGGUAGUAGAUUGUAUAGUU............................................................... 17 2 hsa-let-7f-2_L01_M ESC_WT_454 hsa-let-7g chr3:52277314-52277437 - GCCUGAUUCCAGGCUGAGGUAGUAGUUUGUACAGUUUGAGGGUCUAUGAUACCACCCGGUACAGGAGAUAACUGUACAGGCCACUGCCUUGCCAGGAACAGCG ((.((.((((.(((.((((((((.((((((((((((.....((((.((.((((....))))))..)))))))))))))))).))))))))))).)))))))). (-48.00) ..............UGAGGUAGUAGUUUGUACAGUU................................................................... 7 1 hsa-let-7g_L01_M ESC_WT_454 .......................................................................CUGUACAGGCCACUGCCUUGC........... 3 1 hsa-let-7g_R01*_M ESC_WT_454 hsa-let-7i chr12:61283713-61283836 + ACCAUGGCCCUGGCUGAGGUAGUAGUUUGUGCUGUUGGUCGGGUUGUGACAUUGCCCGCUGUGGAGAUAACUGCGCAAGCUACUGCCUUGCUAGUGCUGGUGAU ((((..((.(((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))).))))))... (-49.50) ..............UGAGGUAGUAGUUUGUGCUGUU.................................................................... 4 1 hsa-let-7i_L01_M ESC_WT_454 ..............UGAGGUAGUAGUUUGUGCUG...................................................................... 1 1 hsa-let-7i_L02 ESC_WT_454 hsa-mir-1-1 chr20:60561938-60562048 + CUGCCUGCUUGGGAAACAUACUUCUUUAUAUGCCCAUAUGGACCUGCUAAGCUAUGGAAUGUAAAGAAGUAUGUAUCUCAGGCCGGGACC ...((.((((((((.((((((((((((((((..((((((((.....)))...))))).)))))))))))))))).)))))))).)).... (-40.90) ......................................................UGGAAUGUAAAGAAGUAUGUAU.............. 2 2 hsa-mir-1-1_R01_M ESC_WT_454 hsa-mir-1-2 chr18:17662943-17663067 - AACUUAGUAAUACCUACUCAGAGUACAUACUUCUUUAUGUACCCAUAUGAACAUACAAUGCUAUGGAAUGUAAAGAAGUAUGUAUUUUUGGUAGGCAAUAAACCA ............((((((.(((((((((((((((((((((..(((((..............))))).))))))))))))))))))))).)))))).......... (-35.64) ...............................................................UGGAAUGUAAAGAAGUAUGUAU.................... 2 2 hsa-mir-1-2_R01_M ESC_WT_454 hsa-mir-101-1 chr1:65296685-65296799 - ACUGACAGGCUGCCCUGGCUCAGUUAUCACAGUGCUGAUGCUGUCUAUUCUAAAGGUACAGUACUGUGAUAACUGAAGGAUGGCAGCCAUCUUA .......(((((((.....((((((((((((((((((.((((............)))))))))))))))))))))).....)))))))...... (-47.30) ...................UCAGUUAUCACAGUGCUGAUGC..................................................... 3 1 hsa-mir-101-1_L01*_M ESC_WT_454 ....................CAGUUAUCACAGUGCUGAUGC..................................................... 2 1 hsa-mir-101-1_L02* ESC_WT_454 ....................CAGUUAUCACAGUGCUGAUGCU.................................................... 1 1 hsa-mir-101-1_L03* ESC_WT_454 ........................................................UACAGUACUGUGAUAACUGAAG................ 13 2 hsa-mir-101-1_R01_M ESC_WT_454 .......................................................GUACAGUACUGUGAUAACUGA.................. 6 2 hsa-mir-101-1_R02 ESC_WT_454 .......................................................GUACAGUACUGUGAUAACUGA.................. 4 2 hsa-mir-101-1_R03 ESC_DGCR8_454 ........................................................UACAGUACUGUGAUAACUGAA................. 3 2 hsa-mir-101-1_R04 ESC_WT_454 .......................................................GUACAGUACUGUGAUAACUGAA................. 3 2 hsa-mir-101-1_R05 ESC_WT_454 ...........................................................AGUACUGUGAUAACUGAA................. 2 2 hsa-mir-101-1_R06 ESC_WT_454 ........................................................UACAGUACUGUGAUAACUGA.................. 1 2 hsa-mir-101-1_R07 ESC_WT_454 hsa-mir-101-2 chr9:4840277-4840395 + UGAGACUGAACUGUCCUUUUUCGGUUAUCAUGGUACCGAUGCUGUAUAUCUGAAAGGUACAGUACUGUGAUAACUGAAGAAUGGUGGUGCCAUCACAUU ...((.((.((..((.((((((((((((((((((((.(.((((............))))).)))))))))))))))))))).))..))..))))..... (-34.20) .....................CGGUUAUCAUGGUACCGAUGCUG....................................................... 4 1 hsa-mir-101-2_L01*_M ESC_WT_454 ....................UCGGUUAUCAUGGUACCGAUGC......................................................... 1 1 hsa-mir-101-2_L02* ESC_WT_454 ....................UCGGUUAUCAUGGUACCGAUGCU........................................................ 1 1 hsa-mir-101-2_L03* ESC_WT_454 .........................................................UACAGUACUGUGAUAACUGAAG.................... 13 2 hsa-mir-101-2_R01_M ESC_WT_454 ........................................................GUACAGUACUGUGAUAACUGA...................... 6 2 hsa-mir-101-2_R02 ESC_WT_454 ........................................................GUACAGUACUGUGAUAACUGA...................... 4 2 hsa-mir-101-2_R03 ESC_DGCR8_454 ........................................................GUACAGUACUGUGAUAACUGAA..................... 3 2 hsa-mir-101-2_R04 ESC_WT_454 .........................................................UACAGUACUGUGAUAACUGAA..................... 3 2 hsa-mir-101-2_R05 ESC_WT_454 ............................................................AGUACUGUGAUAACUGAA..................... 2 2 hsa-mir-101-2_R06 ESC_WT_454 .........................................................UACAGUACUGUGAUAACUGA...................... 1 2 hsa-mir-101-2_R07 ESC_WT_454 hsa-mir-103-1 chr5:167920459-167920576 - GAAGUUUUCUUACUGCCCUCGGCUUCUUUACAGUGCUGCCUUGUUGCAUAUGGAUCAAGCAGCAUUGUACAGGGCUAUGAAGGCAUUGAGACCUGUUCUUCAUG ((((...(((((.((((.((((((.((.(((((((((((.(((.(.(....).).)))))))))))))).))))))..)).)))).)))))......))))... (-39.00) .........................................................AGCAGCAUUGUACAGGGCUAUGA........................ 53 2 hsa-mir-103-1_R01_M ESC_WT_454 .........................................................AGCAGCAUUGUACAGGGCUAUG......................... 9 2 hsa-mir-103-1_R02 ESC_WT_454 .........................................................AGCAGCAUUGUACAGGGCUAUGAA....................... 4 2 hsa-mir-103-1_R03 ESC_WT_454 .........................................................AGCAGCAUUGUACAGGGCUAU.......................... 2 3 hsa-mir-103-1_R04 ESC_WT_454 ...........................................................CAGCAUUGUACAGGGCUAUGA........................ 2 2 hsa-mir-103-1_R05 ESC_WT_454 ...........................................................CAGCAUUGUACAGGGCUAUGAA....................... 2 2 hsa-mir-103-1_R06 ESC_WT_454 ..............................................................CAUUGUACAGGGCUAUGA........................ 2 2 hsa-mir-103-1_R07 ESC_WT_454 ............................................................AGCAUUGUACAGGGCUAUGA........................ 1 2 hsa-mir-103-1_R08 ESC_WT_454 hsa-mir-103-2 chr20:3846121-3846238 + GCUGCGUCUUUGUGCUUUCAGCUUCUUUACAGUGCUGCCUUGUAGCAUUCAGGUCAAGCAGCAUUGUACAGGGCUAUGAAAGAACCAAGAAUGGGCU (((...((((.((.(((((((((.((.(((((((((((((((.......))))....))))))))))).)))))..)))))).)).))))...))). (-36.00) ...................AGCUUCUUUACAGUGCUGCCUUG....................................................... 1 1 hsa-mir-103-2_L01*_M ESC_WT_454 ........................................................AGCAGCAUUGUACAGGGCUAUGA.................. 53 2 hsa-mir-103-2_R01_M ESC_WT_454 ........................................................AGCAGCAUUGUACAGGGCUAUG................... 9 2 hsa-mir-103-2_R02 ESC_WT_454 ........................................................AGCAGCAUUGUACAGGGCUAUGAA................. 4 2 hsa-mir-103-2_R03 ESC_WT_454 ........................................................AGCAGCAUUGUACAGGGCUAU.................... 2 3 hsa-mir-103-2_R04 ESC_WT_454 ..........................................................CAGCAUUGUACAGGGCUAUGA.................. 2 2 hsa-mir-103-2_R05 ESC_WT_454 ..........................................................CAGCAUUGUACAGGGCUAUGAA................. 2 2 hsa-mir-103-2_R06 ESC_WT_454 .............................................................CAUUGUACAGGGCUAUGA.................. 2 2 hsa-mir-103-2_R07 ESC_WT_454 ...........................................................AGCAUUGUACAGGGCUAUGA.................. 1 2 hsa-mir-103-2_R08 ESC_WT_454 hsa-mir-106a chrX:133131874-133131994 - CAGGAAUAGGCCUUGGCCAUGUAAAAGUGCUUACAGUGCAGGUAGCUUUUUGAGAUCUACUGCAAUGUAAGCACUUCUUACAUUACCAUGGUGAUUUAGU ...((((..(((.(((..(((((((((((((((((.(((((.(((.((.....)).)))))))).))))))))))).))))))..))).))).))))... (-38.80) .......................AAAGUGCUUACAGUGCAGGUAG....................................................... 3 2 hsa-mir-106a_L01_M ESC_WT_454 .......................AAAGUGCUUACAGUGCAGGU......................................................... 1 2 hsa-mir-106a_L02 ESC_WT_454 .......................AAAGUGCUUACAGUGCAGGUA........................................................ 1 2 hsa-mir-106a_L03 ESC_WT_454 hsa-mir-106b chr7:99529532-99529653 - UCCCCACCUCCCGCUCCAGCCCUGCCGGGGCUAAAGUGCUGACAGUGCAGAUAGUGGUCCUCUCCGUGCUACCGCACUGUGGGUACUUGCUGCUCCAGCAGGGCACGCACAGCGUCCGUGG ...((((....((((...(((((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))))......))))...)))) (-60.10) ...............................UAAAGUGCUGACAGUGCAGAUA.................................................................... 91 1 hsa-mir-106b_L01_M ESC_WT_454 ...............................UAAAGUGCUGACAGUGCAGAU..................................................................... 65 1 hsa-mir-106b_L02 ESC_WT_454 ...............................UAAAGUGCUGACAGUGCAGAUAG................................................................... 6 1 hsa-mir-106b_L03 ESC_WT_454 ...............................UAAAGUGCUGACAGUGCAGAUA.................................................................... 5 1 hsa-mir-106b_L04 ESC_DGCR8_454 ...............................UAAAGUGCUGACAGUGCAG....................................................................... 2 1 hsa-mir-106b_L05 ESC_WT_454 ...............................UAAAGUGCUGACAGUGCAGA...................................................................... 2 1 hsa-mir-106b_L06 ESC_WT_454 ................................AAAGUGCUGACAGUGCAGAUA.................................................................... 1 1 hsa-mir-106b_L07 ESC_WT_454 ..............................CUAAAGUGCUGACAGUGCAGAUA.................................................................... 1 1 hsa-mir-106b_L08 ESC_WT_454 .......................................................................CCGCACUGUGGGUACUUGCUG............................. 11 1 hsa-mir-106b_R01*_M ESC_WT_454 .......................................................................CCGCACUGUGGGUACUUGCUGC............................ 2 1 hsa-mir-106b_R02* ESC_WT_454 .....................................................................UACCGCACUGUGGGUACUUGCU.............................. 2 1 hsa-mir-106b_R03* ESC_WT_454 .....................................................................UACCGCACUGUGGGUACUUGCUGC............................ 1 1 hsa-mir-106b_R04* ESC_WT_454 .......................................................................CCGCACUGUGGGUACUUGCU.............................. 1 1 hsa-mir-106b_R05* ESC_WT_454 .......................................................................CCGCACUGUGGGUACUUG................................ 1 1 hsa-mir-106b_R06* ESC_WT_454 hsa-mir-107 chr10:91342464-91342584 - UGCAAUAUUCGAUAUUCUCUCUGCUUUCAGCUUCUUUACAGUGUUGCCUUGUGGCAUGGAGUUCAAGCAGCAUUGUACAGGGCUAUCAAAGCACAGAGAGCUUGCU .((((.........((((((.((((((.((((.((.(((((((((((.(((.(((.....))))))))))))))))).))))))...)))))).)))))).)))). (-35.80) ............................AGCUUCUUUACAGUGUUGCCUUG....................................................... 1 1 hsa-mir-107_L01*_M ESC_WT_454 .................................................................AGCAGCAUUGUACAGGGCUAU.................... 2 3 hsa-mir-107_R01_M ESC_WT_454 .................................................................AGCAGCAUUGUACAGGGCUAUC................... 1 1 hsa-mir-107_R02 ESC_WT_454 hsa-mir-10a chr17:44012179-44012328 - GGGCCAAGAAGAUCUGUCUGUCUUCUGUAUAUACCCUGUAGAUCCGAAUUUGUGUAAGGAAUUUUGUGGUCACAAAUUCGUAUCUAGGGGAAUAUGUAGUUGACAUAAACACUCCGCUCUUAUUUUUCCAGAAG ((((..((.(((....)))(((..((((((((.((((.(((((.((((((((((................)))))))))).))))))))).))))))))..))).......))..))))............... (-36.19) ...............................UACCCUGUAGAUCCGAAUUUGU................................................................................. 1 1 hsa-mir-10a_L01_M ESC_WT_454 hsa-mir-10b chr2:176723257-176723406 + GGGUGGGACCCAGAGGUUGUAACGUUGUCUAUAUAUACCCUGUAGAACCGAAUUUGUGUGGUAUCCGUAUAGUCACAGAUUCGAUUCUAGGGGAAUAUAUGGUCGAUGCAAAAACUUCACGUUUCUUCG (((.....))).((((((....(((((.((((((((.((((.(((((.((((((((((..(((....)))...)))))))))).))))))))).)))))))).)))))....))))))........... (-49.40) ...................................UACCCUGUAGAACCGAAUUUGUG....................................................................... 3 1 hsa-mir-10b_L01_M ESC_WT_454 hsa-mir-1197 chr14:100561634-100561761 + GGUCAGCGUCACUUCCUGGUAUUUGAAGAUGCGGUUGACCAUGGUGUGUACGCUUUAUUUGUGACGUAGGACACAUGGUCUACUUCUUCUCAAUAUCACAUCUCGCCU .....(((........(((((((.(((((...(((.(((((((...(.(((((.........).)))).)...))))))).))))))))..))))))).....))).. (-29.32) ...............................CGGUUGACCAUGGUGUGUACG........................................................ 3 1 hsa-mir-1197_L01*_M ESC_WT_454 ..................................................................UAGGACACAUGGUCUACUUCU..................... 8 1 hsa-mir-1197_R01_M ESC_WT_454 hsa-mir-122 chr18:54269266-54269390 + ACAGAGUUUCCUUAGCAGAGCUGUGGAGUGUGACAAUGGUGUUUGUGUCUAAACUAUCAAACGCCAUUAUCACACUAAAUAGCUACUGCUAGGCAAUCCUUCCC ..((..((.(((.(((((((((((..(((((((.(((((((((((.((....))...))))))))))).)))))))..)))))).)))))))).))..)).... (-47.20) .......................UGGAGUGUGACAAUGGUGUUU............................................................ 14 1 hsa-mir-122_L01_M ESC_DGCR8_454 .......................UGGAGUGUGACAAUGGUGUUU............................................................ 1 1 hsa-mir-122_L02 ESC_WT_454 hsa-mir-124-1 chr8:9798288-9798412 - CCUUUCCUUCCUCAGGAGAAAGGCCUCUCUCUCCGUGUUCACAGCGGACCUUGAUUUAAAUGUCCAUACAAUUAAGGCACGCGGUGAAUGCCAAGAAUGGGGCUGGCUGAGCAC ..........(((((......((((((..(((..((((((((.(((..((((((((.............))))))))..))).))))))))..)))..))))))..)))))... (-40.92) .................................CGUGUUCACAGCGGACCUUG............................................................. 1 3 hsa-mir-124-1_L01*_M ESC_WT_454 ........................................................................UAAGGCACGCGGUGAAUGCCA..................... 172 3 hsa-mir-124-1_R01_M ESC_WT_454 ........................................................................UAAGGCACGCGGUGAAUGCC...................... 57 3 hsa-mir-124-1_R02 ESC_WT_454 ........................................................................UAAGGCACGCGGUGAAUGCCAA.................... 45 3 hsa-mir-124-1_R03 ESC_WT_454 ........................................................................UAAGGCACGCGGUGAAUGC....................... 24 3 hsa-mir-124-1_R04 ESC_WT_454 .......................................................................UUAAGGCACGCGGUGAAUGCCA..................... 19 3 hsa-mir-124-1_R05 ESC_WT_454 .......................................................................UUAAGGCACGCGGUGAAUGCC...................... 6 3 hsa-mir-124-1_R06 ESC_WT_454 .......................................................................UUAAGGCACGCGGUGAAUGC....................... 3 3 hsa-mir-124-1_R07 ESC_WT_454 .......................................................................UUAAGGCACGCGGUGAAUGCC...................... 2 3 hsa-mir-124-1_R08 ESC_DGCR8_454 ........................................................................UAAGGCACGCGGUGAAUGCCAAGA.................. 2 3 hsa-mir-124-1_R09 ESC_WT_454 ........................................................................UAAGGCACGCGGUGAAUGCCA..................... 1 3 hsa-mir-124-1_R10 ESC_DGCR8_454 ........................................................................UAAGGCACGCGGUGAAUGCC...................... 1 3 hsa-mir-124-1_R11 ESC_DGCR8_454 ........................................................................UAAGGCACGCGGUGAAUGCCAAG................... 1 3 hsa-mir-124-1_R12 ESC_WT_454 .........................................................................AAGGCACGCGGUGAAUGCCA..................... 1 3 hsa-mir-124-1_R13 ESC_WT_454 hsa-mir-124-2 chr8:65454240-65454388 + ACUUUCCGGAUCAAGAUUAGAGGCUCUGCUCUCCGUGUUCACAGCGGACCUUGAUUUAAUGUCAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGCGGAGCCUACGGCUGCACUUGAAGGACACCAAA ....(((...(((((..(((((((((((((((..((((((((.(((..((((((((...........))))))))..))).))))))))..))))))))))))....)))..))))).)))....... (-54.20) .................................CGUGUUCACAGCGGACCUUG........................................................................... 1 3 hsa-mir-124-2_L01*_M ESC_WT_454 ......................................................................UAAGGCACGCGGUGAAUGCCA..................................... 172 3 hsa-mir-124-2_R01_M ESC_WT_454 ......................................................................UAAGGCACGCGGUGAAUGCC...................................... 57 3 hsa-mir-124-2_R02 ESC_WT_454 ......................................................................UAAGGCACGCGGUGAAUGCCAA.................................... 45 3 hsa-mir-124-2_R03 ESC_WT_454 ......................................................................UAAGGCACGCGGUGAAUGC....................................... 24 3 hsa-mir-124-2_R04 ESC_WT_454 .....................................................................UUAAGGCACGCGGUGAAUGCCA..................................... 19 3 hsa-mir-124-2_R05 ESC_WT_454 .....................................................................UUAAGGCACGCGGUGAAUGCC...................................... 6 3 hsa-mir-124-2_R06 ESC_WT_454 .....................................................................UUAAGGCACGCGGUGAAUGC....................................... 3 3 hsa-mir-124-2_R07 ESC_WT_454 .....................................................................UUAAGGCACGCGGUGAAUGCC...................................... 2 3 hsa-mir-124-2_R08 ESC_DGCR8_454 ......................................................................UAAGGCACGCGGUGAAUGCCAAGA.................................. 2 3 hsa-mir-124-2_R09 ESC_WT_454 ......................................................................UAAGGCACGCGGUGAAUGCCA..................................... 1 3 hsa-mir-124-2_R10 ESC_DGCR8_454 ......................................................................UAAGGCACGCGGUGAAUGCC...................................... 1 3 hsa-mir-124-2_R11 ESC_DGCR8_454 ......................................................................UAAGGCACGCGGUGAAUGCCAAG................................... 1 3 hsa-mir-124-2_R12 ESC_WT_454 .......................................................................AAGGCACGCGGUGAAUGCCA..................................... 1 3 hsa-mir-124-2_R13 ESC_WT_454 hsa-mir-124-3 chr20:61280277-61280403 + CCCCAGCCCUGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCCGCCGCUCCUU ....(((...(((((((.(((((.((((((((.(((..((((((((............))))))))..))).))))))))).)))).))).))))....))).... (-42.20) .......................CGUGUUCACAGCGGACCUUG............................................................... 1 3 hsa-mir-124-3_L01*_M ESC_WT_454 .............................................................UAAGGCACGCGGUGAAUGCCA........................ 172 3 hsa-mir-124-3_R01_M ESC_WT_454 .............................................................UAAGGCACGCGGUGAAUGCC......................... 57 3 hsa-mir-124-3_R02 ESC_WT_454 .............................................................UAAGGCACGCGGUGAAUGCCAA....................... 45 3 hsa-mir-124-3_R03 ESC_WT_454 .............................................................UAAGGCACGCGGUGAAUGC.......................... 24 3 hsa-mir-124-3_R04 ESC_WT_454 ............................................................UUAAGGCACGCGGUGAAUGCCA........................ 19 3 hsa-mir-124-3_R05 ESC_WT_454 ............................................................UUAAGGCACGCGGUGAAUGCC......................... 6 3 hsa-mir-124-3_R06 ESC_WT_454 ............................................................UUAAGGCACGCGGUGAAUGC.......................... 3 3 hsa-mir-124-3_R07 ESC_WT_454 ............................................................UUAAGGCACGCGGUGAAUGCC......................... 2 3 hsa-mir-124-3_R08 ESC_DGCR8_454 .............................................................UAAGGCACGCGGUGAAUGCCAAGA..................... 2 3 hsa-mir-124-3_R09 ESC_WT_454 .............................................................UAAGGCACGCGGUGAAUGCCA........................ 1 3 hsa-mir-124-3_R10 ESC_DGCR8_454 .............................................................UAAGGCACGCGGUGAAUGCC......................... 1 3 hsa-mir-124-3_R11 ESC_DGCR8_454 .............................................................UAAGGCACGCGGUGAAUGCCAAG...................... 1 3 hsa-mir-124-3_R12 ESC_WT_454 ..............................................................AAGGCACGCGGUGAAUGCCA........................ 1 3 hsa-mir-124-3_R13 ESC_WT_454 hsa-mir-1249 chr22:43975479-43975584 - UGUUGGCAUGGGGAGGAGGGAGGAGAUGGGCCAAGUUCCCUCUGGCUGGAACGCCCUUCCCCCCCUUCUUCACCUGGCGAACUCC .(((.((..(((((((((((.((.((.((((...(((((........))))))))).)).))))))))))).))..)).)))... (-41.20) ..................................................ACGCCCUUCCCCCCCUUCUUCA............. 1 1 hsa-mir-1249_R01_M ESC_WT_454 hsa-mir-125a chr19:56888299-56888424 + ACACCAUGUUGCCAGUCUCUAGGUCCCUGAGACCCUUUAACCUGUGAGGACAUCCAGGGUCACAGGUGAGGUUCUUGGGAGCCUGGCGUCUGGCCCAACCACACA ..........(((((.(.(((((..((..(((.((((..((((((((((....))....)))))))))))).)))..))..))))).).)))))........... (-48.10) .......................UCCCUGAGACCCUUUAACCUGUG........................................................... 50 1 hsa-mir-125a_L01_M ESC_WT_454 .......................UCCCUGAGACCCUUUAACCUGUGA.......................................................... 45 1 hsa-mir-125a_L02 ESC_WT_454 .......................UCCCUGAGACCCUUUAACCUGU............................................................ 10 1 hsa-mir-125a_L03 ESC_WT_454 .......................UCCCUGAGACCCUUUAACCUGUG........................................................... 1 1 hsa-mir-125a_L04 ESC_DGCR8_454 .........................CCUGAGACCCUUUAACCUGUGA.......................................................... 1 1 hsa-mir-125a_L05 ESC_WT_454 .............................................................ACAGGUGAGGUUCUUGGGAGCC...................... 7 1 hsa-mir-125a_R01*_M ESC_WT_454 .............................................................ACAGGUGAGGUUCUUGGGAG........................ 1 1 hsa-mir-125a_R02* ESC_WT_454 hsa-mir-125b-1 chr11:121475655-121475782 - AAAACAUUGUUGCGCUCCUCUCAGUCCCUGAGACCCUAACUUGUGAUGUUUACCGUUUAAAUCCACGGGUUAGGCUCUUGGGAGCUGCGAGUCGUGCUUUUGCAUCC .......(((.((((..(((.(((..((..(((.(((((((((((..(((((.....))))).))))))))))).)))..))..))).)))..))))....)))... (-44.50) ........................UCCCUGAGACCCUAACUUGUGA............................................................. 56 2 hsa-mir-125b-1_L01_M ESC_WT_454 ........................UCCCUGAGACCCUAACUUGUG.............................................................. 4 2 hsa-mir-125b-1_L02 ESC_WT_454 .........................CCCUGAGACCCUAACUUGUG.............................................................. 2 2 hsa-mir-125b-1_L03 ESC_WT_454 hsa-mir-125b-2 chr21:16884408-16884536 + CCGCAUCAAACCAGACUUUUCCUAGUCCCUGAGACCCUAACUUGUGAGGUAUUUUAGUAACAUCACAAGUCAGGCUCUUGGGACCUAGGCGGAGGGGAACCAGCAGCU ..((......((...(((..(((((..((..(((.(((.((((((((..(((....)))...)))))))).))).)))..))..)))))..))).)).....)).... (-41.30) .........................UCCCUGAGACCCUAACUUGUGA............................................................. 56 2 hsa-mir-125b-2_L01_M ESC_WT_454 .........................UCCCUGAGACCCUAACUUGUG.............................................................. 4 2 hsa-mir-125b-2_L02 ESC_WT_454 ..........................CCCUGAGACCCUAACUUGUG.............................................................. 2 2 hsa-mir-125b-2_L03 ESC_WT_454 hsa-mir-126 chr9:138684855-138684979 + CCACGCCUCCGCUGGCGACGGGACAUUAUUACUUUUGGUACGCGCUGUGACACUUCAAACUCGUACCGUGAGUAAUAAUGCGCCGUCCACGGCACCGCAUCGAA ....((....((((..((((((.(((((((((((.(((((((.(...(((....)))..).))))))).)))))))))))).)))))..))))...))...... (-40.90) .......................CAUUAUUACUUUUGGUACGCG............................................................ 12 1 hsa-mir-126_L01_M ESC_WT_454 .............................................................CGUACCGUGAGUAAUAAUGCG...................... 12 1 hsa-mir-126_R01*_M ESC_WT_454 ............................................................UCGUACCGUGAGUAAUAAUGCG...................... 7 1 hsa-mir-126_R02* ESC_WT_454 ............................................................UCGUACCGUGAGUAAUAAUGC....................... 1 1 hsa-mir-126_R03* ESC_WT_454 .............................................................CGUACCGUGAGUAAUAAUGC....................... 1 1 hsa-mir-126_R04* ESC_WT_454 ...........................................................CUCGUACCGUGAGUAAUAAUGCG...................... 1 1 hsa-mir-126_R05* ESC_WT_454 hsa-mir-127 chr14:100419049-100419185 + AGGUCUCGCUGUGAUCACUGUCUCCAGCCUGCUGAAGCUCAGAGGGCUCUGAUUCAGAAAGAUCAUCGGAUCCGUCUGAGCUUGGCUGGUCGGAAGUCUCAUCAUCUGCUUCCUUC .((((.......)))).......((((((.....(((((((((.((.((((((((.....))..)))))).)).)))))))))))))))..((((((..........))))))... (-44.50) ...............................CUGAAGCUCAGAGGGCUCUGAUU.............................................................. 6 1 hsa-mir-127_L01*_M ESC_WT_454 ...............................CUGAAGCUCAGAGGGCUCUGAU............................................................... 3 1 hsa-mir-127_L02* ESC_WT_454 .................................GAAGCUCAGAGGGCUCUGAUUC............................................................. 2 1 hsa-mir-127_L03* ESC_WT_454 ...............................CUGAAGCUCAGAGGGCUCUGA................................................................ 1 1 hsa-mir-127_L04* ESC_WT_454 ................................UGAAGCUCAGAGGGCUCUGAU............................................................... 1 1 hsa-mir-127_L05* ESC_WT_454 .................................................................UCGGAUCCGUCUGAGCUUGGCU............................. 61 1 hsa-mir-127_R01_M ESC_WT_454 .................................................................UCGGAUCCGUCUGAGCUUGGC.............................. 10 1 hsa-mir-127_R02 ESC_WT_454 .................................................................UCGGAUCCGUCUGAGCUUGG............................... 8 1 hsa-mir-127_R03 ESC_WT_454 .................................................................UCGGAUCCGUCUGAGCUUGGCUG............................ 2 1 hsa-mir-127_R04 ESC_WT_454 hsa-mir-1274a chr5:41511471-41511581 + UUUGUCCCUGAUGUCCCUGUUUGUCCCUGUUCAGGCGCCACCUGUGGCUGUCUGCCACAAGUACUAUUUGAGACCAUCACUACGACAGUU .(((((..(((((((.(.....((.(.(((.(((((((((....)))).)))))..))).).)).....).)).)))))....))))).. (-23.80) .....................UGUCCCUGUUCAGGCGCCA.................................................. 1 1 hsa-mir-1274a_L01_M ESC_WT_454 hsa-mir-1274b chr19:62716167-62716273 - UCCAGCAGACCUUCUUCACUCACGUCCCUGUUCGGGCGCCACUUGUGGCUGUCGGUUCGGGACUGAAUGAAGAAGGACAAAUGCAG ....(((..(((((((((.(((.(((((.(..(.(((((((....)))).))).)..))))))))).))))))))).....))).. (-40.40) ......................CGUCCCUGUUCGGGCGCCA............................................. 3 1 hsa-mir-1274b_L01_M ESC_DGCR8_454 .......................GUCCCUGUUCGGGCGCCA............................................. 1 1 hsa-mir-1274b_L02 ESC_DGCR8_454 ...................UCACGUCCCUGUUCGGGCGCCA............................................. 1 1 hsa-mir-1274b_L03 ESC_DGCR8_454 .......................GUCCCUGUUCGGGCGCCA............................................. 1 1 hsa-mir-1274b_L04 ESC_WT_454 hsa-mir-128-1 chr2:136139417-136139538 + CCUUGUUCCUGAGCUGUUGGAUUCGGGGCCGUAGCACUGUCUGAGAGGUUUACAUUUCUCACAGUGAACCGGUCUCUUUUUCAGCUGCUUCCUGGCUUCUU .......((.((((.((((((...(((((((...((((((..(((((((....)))))))))))))...)))))))...)))))).))))...))...... (-37.20) ..........................................................UCACAGUGAACCGGUCUCUUU...................... 37 2 hsa-mir-128-1_R01_M ESC_WT_454 ..........................................................UCACAGUGAACCGGUCUCUUUU..................... 8 1 hsa-mir-128-1_R02 ESC_WT_454 hsa-mir-128-2 chr3:35760952-35761075 + CGGCAGCCACUGUGCAGUGGGAAGGGGGGCCGAUACACUGUACGAGAGUGAGUAGCAGGUCUCACAGUGAACCGGUCUCUUUCCCUACUGUGUCACACUCCUAA .((.((.....(..(((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).)))))))..)....))))... (-41.50) .............................................................UCACAGUGAACCGGUCUCUUU...................... 37 2 hsa-mir-128-2_R01_M ESC_WT_454 hsa-mir-1306 chr22:18453561-18453685 + CGCUGCCCCGUGAGCAGUCUCCACCACCUCCCCUGCAAACGUCCAGUGGUGCAGAGGUAAUGGACGUUGGCUCUGGUGGUGAUGGACAGUCCGAACUCCCUGCU .(((((.......))))).((((.((((.((...((.((((((((....(((....))).)))))))).))...)).)))).)))).................. (-36.30) ........................CACCUCCCCUGCAAACGUCC............................................................ 1 1 hsa-mir-1306_L01_M ESC_WT_454 .........................................................UAAUGGACGUUGGCUCUGGUGGU........................ 1 1 hsa-mir-1306_R01*_M ESC_WT_454 ..............................................................GACGUUGGCUCUGGUGGUGAUG.................... 1 1 hsa-mir-1306_R02* ESC_WT_454 hsa-mir-1308 chrX:21990160-21990253 - AAAUUCUAAUCCCCGCAUGGGUGGUUCAGUGGCAGAAUUCUCAAAUUGUAAUCCCCAUAAUCCCCACGUGUUG .............(((.((((.((((..((((..((...(.......)...)).)))))))))))).)))... (-13.00) ..............GCAUGGGUGGUUCAGUGG......................................... 8 1 hsa-mir-1308_L01_M ESC_DGCR8_454 ..............GCAUGGGUGGUUCAGUGG......................................... 1 1 hsa-mir-1308_L02 ESC_WT_454 hsa-mir-130a chr11:57165227-57165355 + GCAUGCCUCUGCUGCUGGCCAGAGCUCUUUUCACAUUGUGCUACUGUCUGCACCUGUCACUAGCAGUGCAAUGUUAAAAGGGCAUUGGCCGUGUAGUGCUACCCAGCG ((.((.....((((((((((((.((((((((.((((((..((.(((...((....))...))).))..)))))).)))))))).))))))).)))))......)))). (-43.90) ...............................................................CAGUGCAAUGUUAAAAGGGCAU....................... 223 1 hsa-mir-130a_R01_M ESC_WT_454 ...............................................................CAGUGCAAUGUUAAAAGGGCAUU...................... 61 1 hsa-mir-130a_R02 ESC_WT_454 ...............................................................CAGUGCAAUGUUAAAAGGGCA........................ 8 1 hsa-mir-130a_R03 ESC_WT_454 ..................................................................UGCAAUGUUAAAAGGGCAU....................... 5 1 hsa-mir-130a_R04 ESC_WT_454 ................................................................AGUGCAAUGUUAAAAGGGCAU....................... 1 1 hsa-mir-130a_R05 ESC_WT_454 ...................................................................GCAAUGUUAAAAGGGCAU....................... 1 1 hsa-mir-130a_R06 ESC_WT_454 .................................................................GUGCAAUGUUAAAAGGGCAU....................... 1 1 hsa-mir-130a_R07 ESC_WT_454 ...............................................................CAGUGCAAUGUUAAAAGGG.......................... 1 1 hsa-mir-130a_R08 ESC_WT_454 hsa-mir-130b chr22:20337573-20337694 + GCACUGGCAGGCCUGCCCGACACUCUUUCCCUGUUGCACUACUAUAGGCCGCUGGGAAGCAGUGCAAUGAUGAAAGGGCAUCGGUCAGGUCCAGCCUGCUACCCUGGGAG (((..(((.((((((.((((..(((((((..(((((((((.((.(((....)))...)).)))))))))..)))))))..)))).))))))..))))))........... (-44.40) .....................ACUCUUUCCCUGUUGCACUACU................................................................... 3 1 hsa-mir-130b_L01*_M ESC_WT_454 ......................CUCUUUCCCUGUUGCACUACU................................................................... 2 1 hsa-mir-130b_L02* ESC_WT_454 ...........................................................CAGUGCAAUGAUGAAAGGGCAU............................. 686 1 hsa-mir-130b_R01_M ESC_WT_454 ............................................................AGUGCAAUGAUGAAAGGGCAU............................. 18 1 hsa-mir-130b_R02 ESC_WT_454 ...........................................................CAGUGCAAUGAUGAAAGGGC............................... 13 1 hsa-mir-130b_R03 ESC_WT_454 ...........................................................CAGUGCAAUGAUGAAAGGGCA.............................. 10 1 hsa-mir-130b_R04 ESC_WT_454 ...........................................................CAGUGCAAUGAUGAAAGGG................................ 6 1 hsa-mir-130b_R05 ESC_WT_454 ..............................................................UGCAAUGAUGAAAGGGCAU............................. 4 1 hsa-mir-130b_R06 ESC_WT_454 ...........................................................CAGUGCAAUGAUGAAAGGGCAU............................. 2 1 hsa-mir-130b_R07 ESC_DGCR8_454 ...........................................................CAGUGCAAUGAUGAAAGGGCAUC............................ 2 1 hsa-mir-130b_R08 ESC_WT_454 ..............................................................UGCAAUGAUGAAAGGGCAU............................. 1 1 hsa-mir-130b_R09 ESC_DGCR8_454 ...........................................................CAGUGCAAUGAUGAAAGGG................................ 1 1 hsa-mir-130b_R10 ESC_DGCR8_454 ...........................................................CAGUGCAAUGAUGAAAGGGCA.............................. 1 1 hsa-mir-130b_R11 ESC_DGCR8_454 ..............................................................UGCAAUGAUGAAAGGGCA.............................. 1 1 hsa-mir-130b_R12 ESC_WT_454 hsa-mir-132 chr17:1899932-1900072 - CGCCGUCCGCGCGCCCCGCCCCCGCGUCUCCAGGGCAACCGUGGCUUUCGAUUGUUACUGUGGGAACUGGAGGUAACAGUCUACAGCCAUGGUCGCCCCGCAGCACGCCCACGCGCCGCGCCACGCCGCGCCC (((.((..(((((...(((....((((((.(.((((.(((((((((...((((((((((..(....)....))))))))))...))))))))).)))).).)).))))....))).)))))...)).)))... (-61.90) .....................................ACCGUGGCUUUCGAUUGUUACU.......................................................................... 1 1 hsa-mir-132_L01*_M ESC_WT_454 .........................................................................UAACAGUCUACAGCCAUGGUCG...................................... 19 1 hsa-mir-132_R01_M ESC_WT_454 .........................................................................UAACAGUCUACAGCCAUGGU........................................ 2 1 hsa-mir-132_R02 ESC_WT_454 .........................................................................UAACAGUCUACAGCCAUGGUC....................................... 1 1 hsa-mir-132_R03 ESC_WT_454 ..........................................................................AACAGUCUACAGCCAUGGUCG...................................... 1 1 hsa-mir-132_R04 ESC_WT_454 hsa-mir-134 chr14:100590757-100590869 + AGCACCGUCCAGGGUGUGUGACUGGUUGACCAGAGGGGCAUGCACUGUGUUCACCCUGUGGGCCACCUAGUCACCAACCCUCAGCAUCACUCCCA ......((..(((((..((((((((.((.(((.((((((((.....))))...)))).)))..)).))))))))..)))))..)).......... (-37.50) ................UGUGACUGGUUGACCAGAGGGG......................................................... 500 1 hsa-mir-134_L01_M ESC_WT_454 ................UGUGACUGGUUGACCAGAGGG.......................................................... 176 1 hsa-mir-134_L02 ESC_WT_454 ................UGUGACUGGUUGACCAGAGG........................................................... 30 1 hsa-mir-134_L03 ESC_WT_454 ..................UGACUGGUUGACCAGAGGGG......................................................... 4 1 hsa-mir-134_L04 ESC_WT_454 ................UGUGACUGGUUGACCAGAGGG.......................................................... 3 1 hsa-mir-134_L05 ESC_DGCR8_454 ................UGUGACUGGUUGACCAGAGGGG......................................................... 3 1 hsa-mir-134_L06 ESC_DGCR8_454 ................UGUGACUGGUUGACCAGAG............................................................ 2 1 hsa-mir-134_L07 ESC_WT_454 ...................GACUGGUUGACCAGAGGGG......................................................... 1 1 hsa-mir-134_L08 ESC_WT_454 .......................................................CUGUGGGCCACCUAGUCACCAA.................. 3 1 hsa-mir-134_R01*_M ESC_WT_454 .......................................................CUGUGGGCCACCUAGUCAC..................... 2 1 hsa-mir-134_R02* ESC_WT_454 ........................................................UGUGGGCCACCUAGUCACCAAC................. 1 1 hsa-mir-134_R03* ESC_WT_454 hsa-mir-135a-1 chr3:52303255-52303384 - GAGCAGCCCCAGGCCUCGCUGUUCUCUAUGGCUUUUUAUUCCUAUGUGAUUCUACUGCUCACUCAUAUAGGGAUUGGAGCCGUGGCGCACGGCGGGGACAGCCAGCGGA ..((.((......(((((((((.(.((((((((((..((((((((((((.............)))))))))))).)))))))))).).)))))))))...))..))... (-47.02) ..........................UAUGGCUUUUUAUUCCUAUGUGA............................................................ 3 2 hsa-mir-135a-1_L01_M ESC_WT_454 hsa-mir-135a-2 chr12:96481701-96481840 + AUCCGACCAAGAUAAAUUCACUCUAGUGCUUUAUGGCUUUUUAUUCCUAUGUGAUAGUAAUAAAGUCUCAUGUAGGGAUGGAAGCCAUGAAAUACAUUGUGAAAAAUCAUCAACUAAGA ..........(((...(((((....(((.((((((((((((.((((((((((((.(.(.....).).)))))))))))))))))))))))).)))...)))))..)))........... (-35.10) ...............................UAUGGCUUUUUAUUCCUAUGUGA................................................................. 3 2 hsa-mir-135a-2_L01_M ESC_WT_454 hsa-mir-135b chr1:203684033-203684169 - UGGACCCCUCCACUCUGCUGUGGCCUAUGGCUUUUCAUUCCUAUGUGAUUGCUGUCCCAAACUCAUGUAGGGCUAAAAGCCAUGGGCUACAGUGAGGGGCGAGCUCCUUCUCCUGC .(((((((((......(((((((((((((((((((...(((((((((((((......)))..))))))))))..))))))))))))))))))))))))).....)))......... (-54.40) .........................UAUGGCUUUUCAUUCCUAUGUGA.................................................................... 156 1 hsa-mir-135b_L01_M ESC_WT_454 .........................UAUGGCUUUUCAUUCCUAUGUG..................................................................... 77 1 hsa-mir-135b_L02 ESC_WT_454 .........................UAUGGCUUUUCAUUCCUAUGU...................................................................... 3 1 hsa-mir-135b_L03 ESC_WT_454 .........................UAUGGCUUUUCAUUCCUAUGUGA.................................................................... 1 1 hsa-mir-135b_L04 ESC_DGCR8_454 ........................CUAUGGCUUUUCAUUCCUAUGUG..................................................................... 1 1 hsa-mir-135b_L05 ESC_WT_454 ................................................................AUGUAGGGCUAAAAGCCAUGGG.............................. 10 1 hsa-mir-135b_R01*_M ESC_WT_454 .................................................................UGUAGGGCUAAAAGCCAUGGG.............................. 2 1 hsa-mir-135b_R02* ESC_WT_454 .................................................................UGUAGGGCUAAAAGCCAUGGGC............................. 2 1 hsa-mir-135b_R03* ESC_WT_454 hsa-mir-136 chr14:100420772-100420893 + GGUGUUGGAUGAGCCCUCGGAGGACUCCAUUUGUUUUGAUGAUGGAUUCUUAUGCUCCAUCAUCGUCUCAAAUGAGUCUUCAGAGGGUUCUAUCAUUUCGU .......(((((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).)))....... (-48.10) .......................ACUCCAUUUGUUUUGAUGAUGG........................................................ 1073 1 hsa-mir-136_L01_M ESC_WT_454 .......................ACUCCAUUUGUUUUGAUGAUGGA....................................................... 732 1 hsa-mir-136_L02 ESC_WT_454 .....................GGACUCCAUUUGUUUUGAUGAU.......................................................... 55 1 hsa-mir-136_L03 ESC_WT_454 ........................CUCCAUUUGUUUUGAUGAUGGA....................................................... 32 1 hsa-mir-136_L04 ESC_WT_454 ........................CUCCAUUUGUUUUGAUGAUGG........................................................ 15 1 hsa-mir-136_L05 ESC_WT_454 ....................AGGACUCCAUUUGUUUUGAUGAU.......................................................... 14 1 hsa-mir-136_L06 ESC_WT_454 .......................ACUCCAUUUGUUUUGAUGAU.......................................................... 12 1 hsa-mir-136_L07 ESC_WT_454 ...........................CAUUUGUUUUGAUGAUGG........................................................ 6 1 hsa-mir-136_L08 ESC_WT_454 .......................ACUCCAUUUGUUUUGAUGAUG......................................................... 5 1 hsa-mir-136_L09 ESC_WT_454 .......................ACUCCAUUUGUUUUGAUGAUGGA....................................................... 3 1 hsa-mir-136_L10 ESC_DGCR8_454 .....................GGACUCCAUUUGUUUUGAUGA........................................................... 3 1 hsa-mir-136_L11 ESC_WT_454 ..........................CCAUUUGUUUUGAUGAUGGA....................................................... 3 1 hsa-mir-136_L12 ESC_WT_454 .......................ACUCCAUUUGUUUUGAUGAUGG........................................................ 2 1 hsa-mir-136_L13 ESC_DGCR8_454 ..........................CCAUUUGUUUUGAUGAUGG........................................................ 2 1 hsa-mir-136_L14 ESC_WT_454 ......................GACUCCAUUUGUUUUGAUGAUGG........................................................ 2 1 hsa-mir-136_L15 ESC_WT_454 ...........................CAUUUGUUUUGAUGAUGGA....................................................... 2 1 hsa-mir-136_L16 ESC_WT_454 .....................GGACUCCAUUUGUUUUGAUGAU.......................................................... 1 1 hsa-mir-136_L17 ESC_DGCR8_454 .......................ACUCCAUUUGUUUUGAUGA........................................................... 1 1 hsa-mir-136_L18 ESC_WT_454 ....................AGGACUCCAUUUGUUUUGAUGA........................................................... 1 1 hsa-mir-136_L19 ESC_WT_454 .....................GGACUCCAUUUGUUUUGAUGAUGG........................................................ 1 1 hsa-mir-136_L20 ESC_WT_454 .......................ACUCCAUUUGUUUUGAUGAUGGAU...................................................... 1 1 hsa-mir-136_L21 ESC_WT_454 .........................................................CAUCAUCGUCUCAAAUGAGUCU...................... 8 1 hsa-mir-136_R01*_M ESC_WT_454 ..........................................................AUCAUCGUCUCAAAUGAGU........................ 1 1 hsa-mir-136_R02* ESC_WT_454 hsa-mir-138-1 chr3:44130688-44130826 + CAGAGACCUCCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGGCAGCAUUCCAG ..(((..((.((((...((((((((((.(((..(((((((((((((...(((((((..(.....)..)))))))..))))))))))))).))).)))))))))))))).))..)))... (-61.00) ...............................AGCUGGUGUUGUGAAUCAGGCCGU................................................................ 4 1 hsa-mir-138-1_L01_M ESC_WT_454 ...............................AGCUGGUGUUGUGAAUCAGGCCG................................................................. 3 2 hsa-mir-138-1_L02 ESC_WT_454 hsa-mir-138-2 chr16:55449911-55450034 + GCGGAGUUCUGGUAUCGUUGCUGCAGCUGGUGUUGUGAAUCAGGCCGACGAGCAGCGCAUCCUCUUACCCGGCUAUUUCACGACACCAGGGUUGCAUCAUACCCAUCCUCUC ..((((....(((((.(.(((.((..(((((((((((((...(((((..(((.((......)))))...)))))..))))))))))))).)).))).))))))....)))). (-44.40) ........................AGCUGGUGUUGUGAAUCAGGCCG................................................................. 3 2 hsa-mir-138-2_L01_M ESC_WT_454 ........................AGCUGGUGUUGUGAAUCAGGCCGA................................................................ 2 1 hsa-mir-138-2_L02 ESC_WT_454 hsa-mir-139 chr11:72003735-72003842 - CUGGGACUGGCUCAGGUGUAUUCUACAGUGCACGUGUCUCCAGUGUGGCUCGGAGGCUGGAGACGCGGCCCUGUUGGAGUAACAACUGAAGC .........((((((.((((((((((((.((.((((((((((((.(.......).)))))))))))))).))).)))))).))).))).))) (-42.10) .....................UCUACAGUGCACGUGUCUCCAGU................................................ 11 1 hsa-mir-139_L01_M ESC_WT_454 ..........................AGUGCACGUGUCUCCAGU................................................ 1 1 hsa-mir-139_L02 ESC_WT_454 .........................................................UGGAGACGCGGCCCUGUUGGAGU............ 2 1 hsa-mir-139_R01*_M ESC_WT_454 hsa-mir-140 chr16:68524465-68524604 + CCGCGCCCUGUGUGUGUCUCUCUCUGUGUCCUGCCAGUGGUUUUACCCUAUGGUAGGUUACGUCAUGCUGUUCUACCACAGGGUAGAACCACGGACAGGAUACCGGGGCACCCUCUGCGUCG ..((((...(.(.(((((((.....((((((((((.(((((((((((((.(((((((..(((......)))))))))).))))))))))))))).)))))))).))))))).).).)))).. (-60.20) ..................................CAGUGGUUUUACCCUAUGGUAG.................................................................. 29 1 hsa-mir-140_L01_M ESC_WT_454 ..................................CAGUGGUUUUACCCUAUGGUA................................................................... 6 1 hsa-mir-140_L02 ESC_WT_454 ..........................................................................ACCACAGGGUAGAACCACGGAC.......................... 3 1 hsa-mir-140_R01*_M ESC_WT_454 .........................................................................UACCACAGGGUAGAACCACGGA........................... 1 1 hsa-mir-140_R02* ESC_WT_454 ..........................................................................ACCACAGGGUAGAACCACGGA........................... 1 1 hsa-mir-140_R03* ESC_WT_454 hsa-mir-141 chr12:6943501-6943635 + AGUUCUCUGUCGGCCGGCCCUGGGUCCAUCUUCCAGUACAGUGUUGGAUGGUCUAAUUGUGAAGCUCCUAACACUGUCUGGUAAAGAUGGCUCCCGGGUGGGUUCUCUCGGCAGU ......(((((((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).))).....)))))). (-55.30) ....................................................................UAACACUGUCUGGUAAAGAUGGC........................ 453 1 hsa-mir-141_R01_M ESC_WT_454 ....................................................................UAACACUGUCUGGUAAAGAUGG......................... 273 1 hsa-mir-141_R02 ESC_WT_454 ....................................................................UAACACUGUCUGGUAAAGAUGGCU....................... 9 1 hsa-mir-141_R03 ESC_WT_454 ....................................................................UAACACUGUCUGGUAAAGAUGGC........................ 6 1 hsa-mir-141_R04 ESC_DGCR8_454 ....................................................................UAACACUGUCUGGUAAAGAUGG......................... 3 1 hsa-mir-141_R05 ESC_DGCR8_454 ......................................................................ACACUGUCUGGUAAAGAUGGC........................ 2 1 hsa-mir-141_R06 ESC_WT_454 .....................................................................AACACUGUCUGGUAAAGAUGGC........................ 2 1 hsa-mir-141_R07 ESC_WT_454 .......................................................................CACUGUCUGGUAAAGAUGGC........................ 2 1 hsa-mir-141_R08 ESC_WT_454 ........................................................................ACUGUCUGGUAAAGAUGGC........................ 1 1 hsa-mir-141_R09 ESC_WT_454 ......................................................................ACACUGUCUGGUAAAGAUGG......................... 1 1 hsa-mir-141_R10 ESC_WT_454 ....................................................................UAACACUGUCUGGUAAAGAUG.......................... 1 1 hsa-mir-141_R11 ESC_WT_454 .........................................................................CUGUCUGGUAAAGAUGGC........................ 1 1 hsa-mir-141_R12 ESC_WT_454 ...................................................................CUAACACUGUCUGGUAAAGAUGG......................... 1 1 hsa-mir-141_R13 ESC_WT_454 ........................................................................ACUGUCUGGUAAAGAUGG......................... 1 1 hsa-mir-141_R14 ESC_WT_454 hsa-mir-142 chr17:53763572-53763698 - CGGACAGACAGACAGUGCAGUCACCCAUAAAGUAGAAAGCACUACUAACAGCACUGGAGGGUGUAGUGUUUCCUACUUUAUGGAUGAGUGUACUGUGGGCUUCGGA (.((.((.(..((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).))))))))..))))).). (-47.40) .........................CAUAAAGUAGAAAGCACUACU............................................................ 4 1 hsa-mir-142_L01*_M ESC_WT_454 .......................CCCAUAAAGUAGAAAGCACUAC............................................................. 2 1 hsa-mir-142_L02* ESC_WT_454 ......................ACCCAUAAAGUAGAAAGCACUA.............................................................. 1 1 hsa-mir-142_L03* ESC_WT_454 .............................................................UGUAGUGUUUCCUACUUUAUGGA...................... 417 1 hsa-mir-142_R01_M ESC_WT_454 .............................................................UGUAGUGUUUCCUACUUUAUGG....................... 107 1 hsa-mir-142_R02 ESC_WT_454 ................................................................AGUGUUUCCUACUUUAUGGAUG.................... 42 1 hsa-mir-142_R03 ESC_WT_454 ..............................................................GUAGUGUUUCCUACUUUAUGGA...................... 29 1 hsa-mir-142_R04 ESC_WT_454 ...............................................................UAGUGUUUCCUACUUUAUGGA...................... 10 1 hsa-mir-142_R05 ESC_WT_454 ...............................................................UAGUGUUUCCUACUUUAUGGAU..................... 2 1 hsa-mir-142_R06 ESC_WT_454 ................................................................AGUGUUUCCUACUUUAUGGAU..................... 2 1 hsa-mir-142_R07 ESC_WT_454 ..............................................................GUAGUGUUUCCUACUUUAUGG....................... 2 1 hsa-mir-142_R08 ESC_WT_454 .............................................................UGUAGUGUUUCCUACUUUAUGGAU..................... 2 1 hsa-mir-142_R09 ESC_WT_454 .............................................................UGUAGUGUUUCCUACUUUAUG........................ 2 1 hsa-mir-142_R10 ESC_WT_454 ................................................................AGUGUUUCCUACUUUAUGGA...................... 2 1 hsa-mir-142_R11 ESC_WT_454 ..............................................................GUAGUGUUUCCUACUUUAUGGAU..................... 1 1 hsa-mir-142_R12 ESC_WT_454 ................................................................AGUGUUUCCUACUUUAUGGAUGA................... 1 1 hsa-mir-142_R13 ESC_WT_454 ................................................................AGUGUUUCCUACUUUAUGG....................... 1 1 hsa-mir-142_R14 ESC_WT_454 hsa-mir-143 chr5:148788654-148788799 + AGCGGAGCAGCGCAGCGCCCUGUCUCCCAGCCUGAGGUGCAGUGCUGCAUCUCUGGUCAGUUGGGAGUCUGAGAUGAAGCACUGUAGCUCAGGAAGAGAGAAGUUGUUCUGCAGCCAUCAGCCUG .((((((((((.(((....)))((((.(..((((((.(((((((((.((((((.((((......)).)).)))))).))))))))).))))))..).)))).))))))))))............. (-59.00) .....................................................................UGAGAUGAAGCACUGUAGCUC................................... 5 1 hsa-mir-143_R01_M ESC_WT_454 .....................................................................UGAGAUGAAGCACUGUAGCUCA.................................. 1 1 hsa-mir-143_R02 ESC_WT_454 hsa-mir-144 chr17:24212657-24212782 - GUGCCCCCAGUGGGGCCCUGGCUGGGAUAUCAUCAUAUACUGUAAGUUUGCGAUGAGACACUACAGUAUAGAUGAUGUACUAGUCCGGGCACCCCCAGCUCUGGA ......((((.(((((((.((((((.((((((((.(((((((((.((((......))))..))))))))))))))))).)))))).)))).)))......)))). (-48.50) .............................................................UACAGUAUAGAUGAUGUACU........................ 1 1 hsa-mir-144_R01_M ESC_WT_454 hsa-mir-145 chr5:148790382-148790509 + ACUCGCUCCCACCUUGUCCUCACGGUCCAGUUUUCCCAGGAAUCCCUUAGAUGCUAAGAUGGGGAUUCCUGGAAAUACUGUUCUUGAGGUCAUGGUUUCACAGCUGG ....(((...(((.((.(((((.((..((((.((.((((((((((((.............)))))))))))).)).))))..))))))).)).))).....)))... (-44.02) ........................GUCCAGUUUUCCCAGGAAUCCCU............................................................ 3 1 hsa-mir-145_L01_M ESC_WT_454 hsa-mir-146b chr10:104186239-104186351 + CUUUGGCCACCUGGCACUGAGAACUGAAUUCCAUAGGCUGUGAGCUCUAGCAAUGCCCUGUGGACUCAGUUCUGGUGCCCGGCAGUGCUACA ...(((((.((.((((((.((((((((..((((((((..((..((....)).))..)))))))).)))))))))))))).))..).)))).. (-41.20) .................UGAGAACUGAAUUCCAUAGGCUGU................................................... 2 1 hsa-mir-146b_L01_M ESC_WT_454 hsa-mir-148a chr7:25956044-25956151 - UUGGUCUUUUGAGGCAAAGUUCUGAGACACUCCGACUCUGAGUAUGAUAGAAGUCAGUGCACUACAGAACUUUGUCUCUAGAGGCUG ..(((((((.((((((((((((((((.((((..(((((((.......))).))))))))..)).)))))))))))))).))))))). (-37.60) .....................................................UCAGUGCACUACAGAACUUUG............. 1 1 hsa-mir-148a_R01_M ESC_WT_454 hsa-mir-148b chr12:53017247-53017385 + CAUCAUUUCCAAGCACGAUUAGCAUUUGAGGUGAAGUUCUGUUAUACACUCAGGCUGUGGCUCUCUGAAAGUCAGUGCAUCACAGAACUUUGUCUCGAAAGCUUUCUAGCAGCUACCC ............((..((..(((.(((((((..(((((((((.((.((((..((((....(.....)..)))))))).)).)))))))))..))))))).))).))..))........ (-36.90) .......................................................................UCAGUGCAUCACAGAACUUUGU......................... 71 1 hsa-mir-148b_R01_M ESC_WT_454 .......................................................................UCAGUGCAUCACAGAACUUU........................... 1 1 hsa-mir-148b_R02 ESC_WT_454 .......................................................................UCAGUGCAUCACAGAACUUUG.......................... 1 1 hsa-mir-148b_R03 ESC_WT_454 hsa-mir-149 chr2:241044071-241044199 + GGCUCCCAGGCCGGCGCCCGAGCUCUGGCUCCGUGUCUUCACUCCCGUGCUUGUCCGAGGAGGGAGGGAGGGACGGGGGCUGUGCUGGGGCAGCUGGAACAACGCAGG .((.......(((((((((.(((.(.(.((((((.(((((.(((((.(.(((....))).))))))))))).)))))).).).))).)))).)))))......))... (-57.42) .......................UCUGGCUCCGUGUCUUCACUCCC.............................................................. 6 1 hsa-mir-149_L01_M ESC_WT_454 .......................UCUGGCUCCGUGUCUUCACUCC............................................................... 5 1 hsa-mir-149_L02 ESC_WT_454 .......................UCUGGCUCCGUGUCUUCACUC................................................................ 1 1 hsa-mir-149_L03 ESC_WT_454 .......................UCUGGCUCCGUGUCUUCACU................................................................. 1 1 hsa-mir-149_L04 ESC_WT_454 hsa-mir-150 chr19:54695834-54695957 - GGCAGCGGCGGCUCCUCUCCCCAUGGCCCUGUCUCCCAACCCUUGUACCAGUGCUGGGCUCAGACCCUGGUACAGGCCUGGGGGACAGGGACCUGGGGACCCCGGCACC .((..(((.((......((((((.((((((((((((((..(((.(((((((.((((....))).).))))))))))..)))))))))))).)))))))))))))))... (-63.30) ...............................UCUCCCAACCCUUGUACCAGUG........................................................ 131 1 hsa-mir-150_L01_M ESC_WT_454 ...............................UCUCCCAACCCUUGUACCAGUGC....................................................... 6 1 hsa-mir-150_L02 ESC_WT_454 ...............................UCUCCCAACCCUUGUACCAGU......................................................... 3 1 hsa-mir-150_L03 ESC_WT_454 ...............................UCUCCCAACCCUUGUACCAGU......................................................... 2 1 hsa-mir-150_L04 ESC_DGCR8_454 ................................CUCCCAACCCUUGUACCAGUG........................................................ 1 1 hsa-mir-150_L05 ESC_WT_454 hsa-mir-151 chr8:141811825-141811954 - CUAAAACACUUUUCCUGCCCUCGAGGAGCUCACAGUCUAGUAUGUCUCAUCCCCUACUAGACUGAAGCUCCUUGAGGACAGGGAUGGUCAUACUCACCUCGGUGUUGCC ....((((((.((((((.((((((((((((..((((((((((.(........).)))))))))).)))))))))))).)))))).(((.......)))..))))))... (-51.40) ....................UCGAGGAGCUCACAGUCUAGU.................................................................... 40 1 hsa-mir-151_L01_M ESC_WT_454 ....................UCGAGGAGCUCACAGUCUAGUA................................................................... 27 1 hsa-mir-151_L02 ESC_WT_454 ....................UCGAGGAGCUCACAGUCUAG..................................................................... 4 1 hsa-mir-151_L03 ESC_WT_454 ....................UCGAGGAGCUCACAGUCUAGUAU.................................................................. 3 1 hsa-mir-151_L04 ESC_WT_454 ...................CUCGAGGAGCUCACAGUCUAGUA................................................................... 2 1 hsa-mir-151_L05 ESC_WT_454 ....................UCGAGGAGCUCACAGUCUAGUA................................................................... 1 1 hsa-mir-151_L06 ESC_DGCR8_454 .....................CGAGGAGCUCACAGUCUAGU.................................................................... 1 1 hsa-mir-151_L07 ESC_WT_454 hsa-mir-152 chr17:43469506-43469632 - GCUCGGCCCGCUGUCCCCCCCGGCCCAGGUUCUGUGAUACACUCCGACUCGGGCUCUGGAGCAGUCAGUGCAUGACAGAACUUGGGCCCGGAAGGACCUUCUGCACC .....((.....((((..((.((((((((((((((.((.((((..((((...(((....))))))))))).)).)))))))))))))).))..)))).....))... (-50.00) ................................................................UCAGUGCAUGACAGAACUUGGG..................... 2 1 hsa-mir-152_R01_M ESC_WT_454 ................................................................UCAGUGCAUGACAGAACUUGG...................... 2 1 hsa-mir-152_R02 ESC_WT_454 hsa-mir-153-1 chr2:219867057-219867186 - CUCUCUCUCCCUCACAGCUGCCAGUGUCAUUUUUGUGAUCUGCAGCUAGUAUUCUCACUCCAGUUGCAUAGUCACAAAAGUGAUCAUUGGCAGGUGUGGCUGCUGCAUGGACAG ....((.(((..((((.((((((((((((((((((((((.((((((((((......)))..)))))))..))))))))))))).))))))))).))))((....))..))).)) (-50.50) ...............................................................UUGCAUAGUCACAAAAGUGAUCAU........................... 1 2 hsa-mir-153-1_R01_M ESC_WT_454 hsa-mir-153-2 chr7:157059769-157059895 - CCAGCUAAUUAGCGGUGGCCAGUGUCAUUUUUGUGAUGUUGCAGCUAGUAAUAUGAGCCCAGUUGCAUAGUCACAAAAGUGAUCAUUGGAAACUGUGACUGUACUG .(((.((....(((((..(((((((((((((((((((..(((((((.((.......))..)))))))..))))))))))))).))))))..))))).....))))) (-42.90) ..............................................................UUGCAUAGUCACAAAAGUGAUCAU.................... 1 2 hsa-mir-153-2_R01_M ESC_WT_454 hsa-mir-154 chr14:100595825-100595948 + CGCUAGCGUGUGGUACUUGAAGAUAGGUUAUCCGUGUUGCCUUCGCUUUAUUUGUGACGAAUCAUACACGGUUGACCUAUUUUUCAGUACCAAAUCCCGCCUU .....(((..(((((((.((((((((((((.((((((....(((((.........).))))....)))))).)))))))))))).))))))).....)))... (-40.50) .......................UAGGUUAUCCGUGUUGCCUUCG.......................................................... 26 1 hsa-mir-154_L01_M ESC_WT_454 .......................UAGGUUAUCCGUGUUGCCUUC........................................................... 1 1 hsa-mir-154_L02 ESC_WT_454 ...........................................................AAUCAUACACGGUUGACCUAUU...................... 7 1 hsa-mir-154_R01*_M ESC_WT_454 ..............................................................CAUACACGGUUGACCUAUU...................... 3 1 hsa-mir-154_R02* ESC_WT_454 .............................................................UCAUACACGGUUGACCUAUU...................... 2 1 hsa-mir-154_R03* ESC_WT_454 ............................................................AUCAUACACGGUUGACCUAUU...................... 1 1 hsa-mir-154_R04* ESC_WT_454 hsa-mir-15a chr13:49521236-49521358 - UAAAAAAAAUAAAACCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGGAUCUGAUCU ..............(((((.......(..((((((((..((((((((((..((.....))..))))))))))..))))))))..).......)))))......... (-32.34) ...........................UAGCAGCACAUAAUGGUUUGU.......................................................... 36 1 hsa-mir-15a_L01_M ESC_WT_454 ...........................UAGCAGCACAUAAUGGUUUGUG......................................................... 35 1 hsa-mir-15a_L02 ESC_WT_454 ...........................UAGCAGCACAUAAUGGUUUGUGGA....................................................... 12 1 hsa-mir-15a_L03 ESC_WT_454 ...........................UAGCAGCACAUAAUGGUUUGUGG........................................................ 5 1 hsa-mir-15a_L04 ESC_WT_454 ...........................UAGCAGCACAUAAUGGUU............................................................. 2 1 hsa-mir-15a_L05 ESC_DGCR8_454 hsa-mir-15b chr3:161605050-161605187 + AAUCCUACAUUUUUGAGGCCUUAAAGUACUGUAGCAGCACAUCAUGGUUUACAUGCUACAGUCAAGAUGCGAAUCAUUAUUUGCUGCUCUAGAAAUUUAAGGAAAUUCAUUCAAAACUAU .............((((.(((((((...(((.(((((((.((.((((((..(((.((.......)))))..)))))).)).))))))).)))...)))))))...))))........... (-32.70) ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 464 1 hsa-mir-15b_L01_M ESC_WT_454 ...............................UAGCAGCACAUCAUGGUUUAC.................................................................... 94 1 hsa-mir-15b_L02 ESC_WT_454 ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 10 1 hsa-mir-15b_L03 ESC_DGCR8_454 ...............................UAGCAGCACAUCAUGGUUUA..................................................................... 8 1 hsa-mir-15b_L04 ESC_WT_454 ...............................UAGCAGCACAUCAUGGUUUAC.................................................................... 4 1 hsa-mir-15b_L05 ESC_DGCR8_454 ...............................UAGCAGCACAUCAUGGUUUACAU.................................................................. 2 1 hsa-mir-15b_L06 ESC_WT_454 ...............................UAGCAGCACAUCAUGGUUUA..................................................................... 1 1 hsa-mir-15b_L07 ESC_DGCR8_454 .................................GCAGCACAUCAUGGUUUAC.................................................................... 1 1 hsa-mir-15b_L08 ESC_DGCR8_454 ................................AGCAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L09 ESC_WT_454 .....................................................................CGAAUCAUUAUUUGCUGCUCU.............................. 9 1 hsa-mir-15b_R01*_M ESC_WT_454 .....................................................................CGAAUCAUUAUUUGCUGCUCUA............................. 1 1 hsa-mir-15b_R02* ESC_WT_454 hsa-mir-16-1 chr13:49521090-49521218 - UGAUAGCAAUGUCAGCAGUGCCUUAGCAGCACGUAAAUAUUGGCGUUAAGAUUCUAAAAUUAUCUCCAGUAUUAACUGUGCUGCUGAAGUAAGGUUGACCAUACUCUACAGUU ..........((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..)))))).............. (-38.50) .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 2736 2 hsa-mir-16-1_L01_M ESC_WT_454 .......................UAGCAGCACGUAAAUAUUGGCGU................................................................... 122 2 hsa-mir-16-1_L02 ESC_WT_454 .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 47 2 hsa-mir-16-1_L03 ESC_DGCR8_454 .......................UAGCAGCACGUAAAUAUUGGC..................................................................... 30 2 hsa-mir-16-1_L04 ESC_WT_454 ........................AGCAGCACGUAAAUAUUGGCG.................................................................... 8 2 hsa-mir-16-1_L05 ESC_WT_454 ...........................AGCACGUAAAUAUUGGCG.................................................................... 8 2 hsa-mir-16-1_L06 ESC_WT_454 .......................UAGCAGCACGUAAAUAUUGG...................................................................... 5 2 hsa-mir-16-1_L07 ESC_WT_454 .......................UAGCAGCACGUAAAUAUUGGCGU................................................................... 4 2 hsa-mir-16-1_L08 ESC_DGCR8_454 ..........................CAGCACGUAAAUAUUGGCG.................................................................... 4 2 hsa-mir-16-1_L09 ESC_WT_454 .........................GCAGCACGUAAAUAUUGGCG.................................................................... 3 2 hsa-mir-16-1_L10 ESC_WT_454 ..........................CAGCACGUAAAUAUUGGCGU................................................................... 1 2 hsa-mir-16-1_L11 ESC_WT_454 hsa-mir-16-2 chr3:161605207-161605327 + UGACAUACUUGUUCCACUCUAGCAGCACGUAAAUAUUGGCGUAGUGAAAUAUAUAUUAAACACCAAUAUUACUGUGCUGCUUUAGUGUGACAGGGAUACAG .......(((((..((((..(((((((((..((((((((.((..(((........))).)).))))))))..)))))))))..))))..)))))....... (-37.40) ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 2736 2 hsa-mir-16-2_L01_M ESC_WT_454 ...................UAGCAGCACGUAAAUAUUGGCGU........................................................... 122 2 hsa-mir-16-2_L02 ESC_WT_454 ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 47 2 hsa-mir-16-2_L03 ESC_DGCR8_454 ...................UAGCAGCACGUAAAUAUUGGC............................................................. 30 2 hsa-mir-16-2_L04 ESC_WT_454 ..................CUAGCAGCACGUAAAUAUUGGCG............................................................ 9 1 hsa-mir-16-2_L05 ESC_WT_454 ....................AGCAGCACGUAAAUAUUGGCG............................................................ 8 2 hsa-mir-16-2_L06 ESC_WT_454 .......................AGCACGUAAAUAUUGGCG............................................................ 8 2 hsa-mir-16-2_L07 ESC_WT_454 ...................UAGCAGCACGUAAAUAUUGG.............................................................. 5 2 hsa-mir-16-2_L08 ESC_WT_454 ...................UAGCAGCACGUAAAUAUUGGCGU........................................................... 4 2 hsa-mir-16-2_L09 ESC_DGCR8_454 ......................CAGCACGUAAAUAUUGGCG............................................................ 4 2 hsa-mir-16-2_L10 ESC_WT_454 .....................GCAGCACGUAAAUAUUGGCG............................................................ 3 2 hsa-mir-16-2_L11 ESC_WT_454 ......................CAGCACGUAAAUAUUGGCGU........................................................... 1 2 hsa-mir-16-2_L12 ESC_WT_454 ...................UAGCAGCACGUAAAUAUUGGCGUA.......................................................... 1 1 hsa-mir-16-2_L13 ESC_WT_454 ..................CUAGCAGCACGUAAAUAUUGGC............................................................. 1 1 hsa-mir-16-2_L14 ESC_WT_454 hsa-mir-17 chr13:90800840-90800963 + UUGUGACCAGUCAGAAUAAUGUCAAAGUGCUUACAGUGCAGGUAGUGAUAUGUGCAUCUACUGCAGUGAAGGCACUUGUAGCAUUAUGGUGACAGCUGCCUCG .........((((..(((((((..((((((((.((.(((((.(((((.......)).)))))))).)).))))))))...)))))))..)))).......... (-36.20) ......................CAAAGUGCUUACAGUGCAGGUAG.......................................................... 456 1 hsa-mir-17_L01_M ESC_WT_454 ......................CAAAGUGCUUACAGUGCAGGUA........................................................... 177 1 hsa-mir-17_L02 ESC_WT_454 ......................CAAAGUGCUUACAGUGCAGGU............................................................ 52 1 hsa-mir-17_L03 ESC_WT_454 ......................CAAAGUGCUUACAGUGCAGGUAGU......................................................... 43 1 hsa-mir-17_L04 ESC_WT_454 .....................UCAAAGUGCUUACAGUGCAGGU............................................................ 11 1 hsa-mir-17_L05 ESC_WT_454 .....................UCAAAGUGCUUACAGUGCAGGUA........................................................... 7 1 hsa-mir-17_L06 ESC_WT_454 ......................CAAAGUGCUUACAGUGCAGG............................................................. 6 1 hsa-mir-17_L07 ESC_WT_454 ......................CAAAGUGCUUACAGUGCAGGUAG.......................................................... 5 1 hsa-mir-17_L08 ESC_DGCR8_454 .....................UCAAAGUGCUUACAGUGCAGGUAG.......................................................... 5 1 hsa-mir-17_L09 ESC_WT_454 .......................AAAGUGCUUACAGUGCAGGUAG.......................................................... 3 2 hsa-mir-17_L10 ESC_WT_454 ......................CAAAGUGCUUACAGUGCAGGU............................................................ 1 1 hsa-mir-17_L11 ESC_DGCR8_454 .......................AAAGUGCUUACAGUGCAGGUA........................................................... 1 2 hsa-mir-17_L12 ESC_WT_454 ............................GCUUACAGUGCAGGUAGU......................................................... 1 1 hsa-mir-17_L13 ESC_WT_454 .......................AAAGUGCUUACAGUGCAGGU............................................................ 1 2 hsa-mir-17_L14 ESC_WT_454 .....................UCAAAGUGCUUACAGUGCAGG............................................................. 1 1 hsa-mir-17_L15 ESC_WT_454 hsa-mir-181b-1 chr1:197094605-197094754 - CUUUCUCUUCCCUGUGCAGAGAUUAUUUUUUAAAAGGUCACAAUCAACAUUCAUUGCUGUCGGUGGGUUGAACUGUGUGGACAAGCUCACUGAACAAUGAAUGCAACUGUGGCCCCGCUUUUUGCUGUC ...(((((.(.....).))))).............(((((((.....(((((((((...((((((((((...((....))...)))))))))).)))))))))....)))))))..((.....)).... (-38.70) .............................................AACAUUCAUUGCUGUCGGUGGGUU............................................................ 2 2 hsa-mir-181b-1_L01_M ESC_WT_454 .............................................AACAUUCAUUGCUGUCGGUGGG.............................................................. 2 2 hsa-mir-181b-1_L02 ESC_WT_454 .............................................AACAUUCAUUGCUGUCGGUGGGU............................................................. 1 2 hsa-mir-181b-1_L03 ESC_WT_454 ..............................................ACAUUCAUUGCUGUCGGUGGG.............................................................. 1 2 hsa-mir-181b-1_L04 ESC_WT_454 hsa-mir-181b-2 chr9:126495790-126495918 + CUGAAAACACUGAUGGCUGCACUCAACAUUCAUUGCUGUCGGUGGGUUUGAGUCUGAAUCAACUCACUGAUCAAUGAAUGCAAACUGCGGACCAAACAACCCAAAGGA .............((((((((.....(((((((((..(((((((((((.((.......)))))))))))))))))))))).....))))).))).....((....)). (-35.30) ........................AACAUUCAUUGCUGUCGGUGGGUU............................................................ 2 2 hsa-mir-181b-2_L01_M ESC_WT_454 ........................AACAUUCAUUGCUGUCGGUGGG.............................................................. 2 2 hsa-mir-181b-2_L02 ESC_WT_454 ........................AACAUUCAUUGCUGUCGGUGGGU............................................................. 1 2 hsa-mir-181b-2_L03 ESC_WT_454 .........................ACAUUCAUUGCUGUCGGUGGG.............................................................. 1 2 hsa-mir-181b-2_L04 ESC_WT_454 hsa-mir-181c chr19:13846493-13846642 + ACUCCAGGUCCCGGAAAAUUUGCCAAGGGUUUGGGGGAACAUUCAACCUGUCGGUGAGUUUGGGCAGCUCAGGCAAACCAUCGACCGUUGAGUGGACCCUGAGGCCUGGAAUUGCCAUCCUCCUGCCGGUG (((.((((....(((.......(((.((.((..(((...((((((((..(((((((.(((((...........)))))))))))).))))))))..)))..)).)))))........))).))))..))). (-49.26) .....................................AACAUUCAACCUGUCGGUGAGUUU...................................................................... 12 1 hsa-mir-181c_L01*_M ESC_WT_454 .....................................AACAUUCAACCUGUCGGUGAGU........................................................................ 4 1 hsa-mir-181c_L02* ESC_WT_454 .....................................AACAUUCAACCUGUCGGUGAGUU....................................................................... 3 1 hsa-mir-181c_L03* ESC_WT_454 .....................................AACAUUCAACCUGUCGGUGAGU........................................................................ 1 1 hsa-mir-181c_L04* ESC_DGCR8_454 ......................................ACAUUCAACCUGUCGGUGAGU........................................................................ 1 1 hsa-mir-181c_L05* ESC_WT_454 ......................................ACAUUCAACCUGUCGGUGAGUU....................................................................... 1 1 hsa-mir-181c_L06* ESC_WT_454 ............................................................................ACCAUCGACCGUUGAGUGGACC................................. 33 1 hsa-mir-181c_R01_M ESC_WT_454 ............................................................................ACCAUCGACCGUUGAGUGGAC.................................. 14 1 hsa-mir-181c_R02 ESC_WT_454 ...........................................................................AACCAUCGACCGUUGAGUGGAC.................................. 4 1 hsa-mir-181c_R03 ESC_WT_454 .............................................................................CCAUCGACCGUUGAGUGGACC................................. 2 1 hsa-mir-181c_R04 ESC_WT_454 ............................................................................ACCAUCGACCGUUGAGUGGAC.................................. 1 1 hsa-mir-181c_R05 ESC_DGCR8_454 ...........................................................................AACCAUCGACCGUUGAGUGGA................................... 1 1 hsa-mir-181c_R06 ESC_WT_454 hsa-mir-181d chr19:13846669-13846845 + CCUGGGCACGUCCCCUCCCCUAGGCCACAGCCGAGGUCACAAUCAACAUUCAUUGUUGUCGGUGGGUUGUGAGGACUGAGGCCAGACCCACCGGGGGAUGAAUGUCACUGUGGCUGGGCCAGACACGGCUUAAGGGGAAUGGGGACUGGGGACAGG ((((..(..(((((((((((((((((...(((..(((((((....(((((((((.(..((((((((((....((.(....))).))))))))))).)))))))))...))))))).))).......))))).))))))..))))))...)..)))) (-76.30) ............................................AACAUUCAUUGUUGUCGGUGGG.......................................................................................... 23 1 hsa-mir-181d_L01_M ESC_WT_454 ............................................AACAUUCAUUGUUGUCGGUGGGU......................................................................................... 18 1 hsa-mir-181d_L02 ESC_WT_454 ............................................AACAUUCAUUGUUGUCGGUGGGUU........................................................................................ 17 1 hsa-mir-181d_L03 ESC_WT_454 .............................................ACAUUCAUUGUUGUCGGUGGGU......................................................................................... 5 1 hsa-mir-181d_L04 ESC_WT_454 .............................................ACAUUCAUUGUUGUCGGUGGGUU........................................................................................ 5 1 hsa-mir-181d_L05 ESC_WT_454 ............................................AACAUUCAUUGUUGUCGGUGG........................................................................................... 1 1 hsa-mir-181d_L06 ESC_WT_454 .............................................ACAUUCAUUGUUGUCGGUGGG.......................................................................................... 1 1 hsa-mir-181d_L07 ESC_WT_454 ..............................................CAUUCAUUGUUGUCGGUGGGU......................................................................................... 1 1 hsa-mir-181d_L08 ESC_WT_454 ......................................................................................CCCACCGGGGGAUGAAUGUCA................................................. 2 1 hsa-mir-181d_R01*_M ESC_WT_454 hsa-mir-182 chr7:129197439-129197588 - CUCCUGGGGGGAGCUGCUUGCCUCCCCCCGUUUUUGGCAAUGGUAGAACUCACACUGGUGAGGUAACAGGAUCCGGUGGUUCUAGACUUGCCAACUAUGGGGCGAGGACUCAGCCGGCACCCUGUGCAC .....(.((((.((((((..((((.((((((..(((((((.(.((((((...((((((..............))))))))))))..))))))))..)))))).))))....)).)))).)))).).... (-54.34) ................................UUUGGCAAUGGUAGAACUCACAC.......................................................................... 105 1 hsa-mir-182_L01_M ESC_WT_454 ................................UUUGGCAAUGGUAGAACUCACA........................................................................... 60 1 hsa-mir-182_L02 ESC_WT_454 ................................UUUGGCAAUGGUAGAACUCAC............................................................................ 4 1 hsa-mir-182_L03 ESC_WT_454 ................................UUUGGCAAUGGUAGAACUCA............................................................................. 2 1 hsa-mir-182_L04 ESC_WT_454 .................................UUGGCAAUGGUAGAACUCACA........................................................................... 2 1 hsa-mir-182_L05 ESC_WT_454 .................................UUGGCAAUGGUAGAACUCACAC.......................................................................... 2 1 hsa-mir-182_L06 ESC_WT_454 ................................UUUGGCAAUGGUAGAACUCACA........................................................................... 1 1 hsa-mir-182_L07 ESC_DGCR8_454 ...............................UUUUGGCAAUGGUAGAACUCACAC.......................................................................... 1 1 hsa-mir-182_L08 ESC_WT_454 .................................UUGGCAAUGGUAGAACUCA............................................................................. 1 1 hsa-mir-182_L09 ESC_WT_454 ................................UUUGGCAAUGGUAGAACUCACACU......................................................................... 1 1 hsa-mir-182_L10 ESC_WT_454 ...................................GGCAAUGGUAGAACUCACAC.......................................................................... 1 1 hsa-mir-182_L11 ESC_WT_454 hsa-mir-1826 chr16:33872989-33873113 + GCAGGACAGAUUGAUCAUCGACACUUCGAACGCAAUUGCAGCCCGGGUUCCUCCCAGGGCUUUGCCUGUCUGAGCGUCGCUUGCCGAUCAGUAGUCCCCGGGGGU ...((((..(((((((..((((.(((.((..((((....((((((((.....))).)))))))))...)).))).))))......))))))).))))........ (-37.40) ..........UUGAUCAUCGACACUUCGAACGCA....................................................................... 2 1 hsa-mir-1826_L01_M ESC_DGCR8_454 ..........UUGAUCAUCGACACUUCGAA........................................................................... 1 1 hsa-mir-1826_L02 ESC_DGCR8_454 ..........UUGAUCAUCGACACUUCGAAC.......................................................................... 1 1 hsa-mir-1826_L03 ESC_DGCR8_454 ..........UUGAUCAUCGACACUUCGA............................................................................ 1 1 hsa-mir-1826_L04 ESC_DGCR8_454 ..............UCAUCGACACUUCGAACG......................................................................... 1 1 hsa-mir-1826_L05 ESC_DGCR8_454 ...............CAUCGACACUUCGAACGCA....................................................................... 1 1 hsa-mir-1826_L06 ESC_DGCR8_454 hsa-mir-183 chr7:129201961-129202110 - GGUCGGCAGGCCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGAGGGCCUCCGGA ..((((.(((((.(...(((.((.(((((((((((.((((((..(((((..(((((((((((......)))..)))))))))))))....)))))).))))))))).))....)))))..)))))))))). (-56.70) ....................................UAUGGCACUGGUAGAAUUCACU......................................................................... 57 1 hsa-mir-183_L01_M ESC_WT_454 ....................................UAUGGCACUGGUAGAAUUCACUG........................................................................ 53 1 hsa-mir-183_L02 ESC_WT_454 .....................................AUGGCACUGGUAGAAUUCACUG........................................................................ 22 1 hsa-mir-183_L03 ESC_WT_454 .........................................CACUGGUAGAAUUCACUG........................................................................ 9 1 hsa-mir-183_L04 ESC_WT_454 .....................................AUGGCACUGGUAGAAUUCACUGU....................................................................... 3 1 hsa-mir-183_L05 ESC_WT_454 ....................................UAUGGCACUGGUAGAAUUCAC.......................................................................... 3 1 hsa-mir-183_L06 ESC_WT_454 ....................................UAUGGCACUGGUAGAAUUCACUGU....................................................................... 2 1 hsa-mir-183_L07 ESC_WT_454 ....................................UAUGGCACUGGUAGAAUUCA........................................................................... 2 1 hsa-mir-183_L08 ESC_WT_454 .......................................GGCACUGGUAGAAUUCACUG........................................................................ 2 1 hsa-mir-183_L09 ESC_WT_454 .....................................AUGGCACUGGUAGAAUUCACU......................................................................... 1 1 hsa-mir-183_L10 ESC_WT_454 ...................................GUAUGGCACUGGUAGAAUUCACU......................................................................... 1 1 hsa-mir-183_L11 ESC_WT_454 ......................................UGGCACUGGUAGAAUUCACUG........................................................................ 1 1 hsa-mir-183_L12 ESC_WT_454 ............................................................................UGAAUUACCGAAGGGCCAUAAA................................. 3 1 hsa-mir-183_R01*_M ESC_WT_454 ............................................................................UGAAUUACCGAAGGGCCAUAA.................................. 1 1 hsa-mir-183_R02* ESC_WT_454 ............................................................................UGAAUUACCGAAGGGCCAUA................................... 1 1 hsa-mir-183_R03* ESC_WT_454 hsa-mir-185 chr22:18400642-18400763 + GGCUCGAGCAGGGGGCGAGGGAUUGGAGAGAAAGGCAGUUCCUGAUGGUCCCCUCCCCAGGGGCUGGCUUUCCUCUGGUCCUUCCCUCCCAAUGACCGCGU ((.(((....(((((.(((((((..(((.(((((.(((((((((..((......)).))))))))).))))))))..))))))))))))...))))).... (-55.00) .......................UGGAGAGAAAGGCAGUUCCUGA........................................................ 9 1 hsa-mir-185_L01_M ESC_WT_454 .......................UGGAGAGAAAGGCAGUUCCUG......................................................... 4 1 hsa-mir-185_L02 ESC_WT_454 ..........................................................AGGGGCUGGCUUUCCUCUGGU...................... 1 1 hsa-mir-185_R01*_M ESC_WT_454 hsa-mir-186 chr1:71305882-71306007 - AUUUUUUCAUUGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCUAAAUUCCUUC ...........(((((.(((((((((((((((((.(((((.((((((..............))))))))))).))))))))))))))))))))))........... (-41.24) ........................CAAAGAAUUCUCCUUUUGGGCUU........................................................... 16 1 hsa-mir-186_L01_M ESC_WT_454 ........................CAAAGAAUUCUCCUUUUGGGCU............................................................ 4 1 hsa-mir-186_L02 ESC_WT_454 ............................GAAUUCUCCUUUUGGGCUU........................................................... 1 1 hsa-mir-186_L03 ESC_WT_454 ........................CAAAGAAUUCUCCUUUUGGGCUUU.......................................................... 1 1 hsa-mir-186_L04 ESC_WT_454 hsa-mir-187 chr18:31738759-31738907 - AGGUGCUGCAGGUCGGGCUCACCAUGACACAGUGUGAGACCUCGGGCUACAACACAGGACCCGGGCGCUGCUCUGACCCCUCGUGUCUUGUGUUGCAGCCGGAGGGACGCAGGUCCGCAGCAGAGCCU (((((((((.(..(...((((((........).))))).((((.((((.(((((((((((.((((.((......).).)).)).))))))))))).)))).))))......)..).)))))...)))) (-58.70) ................................................................................UCGUGUCUUGUGUUGCAGCCGG.......................... 2 1 hsa-mir-187_R01_M ESC_WT_454 ................................................................................UCGUGUCUUGUGUUGCAGCCGGA......................... 1 1 hsa-mir-187_R02 ESC_WT_454 hsa-mir-188 chrX:49654829-49654954 + GCCCUUCCCUGCUCCCUCUCUCACAUCCCUUGCAUGGUGGAGGGUGAGCUUUCUGAAAACCCCUCCCACAUGCAGGGUUUGCAGGAUGGCGAGCCUCAGCUUUCC ..........((((((..(((..((..(((((((((..((((((....(.....).....))))))..)))))))))..))..))).)).))))........... (-39.80) .......................CAUCCCUUGCAUGGUGGAGG.............................................................. 14 1 hsa-mir-188_L01_M ESC_WT_454 .......................CAUCCCUUGCAUGGUGGAG............................................................... 8 1 hsa-mir-188_L02 ESC_WT_454 .......................CAUCCCUUGCAUGGUGGAGGG............................................................. 4 1 hsa-mir-188_L03 ESC_WT_454 .......................CAUCCCUUGCAUGGUGGAGGGU............................................................ 2 1 hsa-mir-188_L04 ESC_WT_454 .......................CAUCCCUUGCAUGGUGGA................................................................ 1 1 hsa-mir-188_L05 ESC_WT_454 hsa-mir-18a chr13:90800986-90801096 + AGUGCUUUUUGUUCUAAGGUGCAUCUAGUGCAGAUAGUGAAGUAGAUUAGCAUCUACUGCCCUAAGUGCUCCUUCUGGCAUAAGAAGUUA ...(((((((((.((((((.(((..(((.((((.(((((..(.....)..)).))))))).)))..))).)))..))).))))))))).. (-27.30) ..............UAAGGUGCAUCUAGUGCAGAUAG..................................................... 620 1 hsa-mir-18a_L01_M ESC_WT_454 ..............UAAGGUGCAUCUAGUGCAGAUA...................................................... 281 1 hsa-mir-18a_L02 ESC_WT_454 ..............UAAGGUGCAUCUAGUGCAGAU....................................................... 200 1 hsa-mir-18a_L03 ESC_WT_454 ..............UAAGGUGCAUCUAGUGCAGA........................................................ 34 1 hsa-mir-18a_L04 ESC_WT_454 ..............UAAGGUGCAUCUAGUGCAGAUAGU.................................................... 20 1 hsa-mir-18a_L05 ESC_WT_454 ..............UAAGGUGCAUCUAGUGCAGAUAG..................................................... 11 1 hsa-mir-18a_L06 ESC_DGCR8_454 ..............UAAGGUGCAUCUAGUGCAG......................................................... 6 2 hsa-mir-18a_L07 ESC_WT_454 ..............UAAGGUGCAUCUAGUGCA.......................................................... 3 2 hsa-mir-18a_L08 ESC_WT_454 ..............UAAGGUGCAUCUAGUGCAGAU....................................................... 1 1 hsa-mir-18a_L09 ESC_DGCR8_454 ..............UAAGGUGCAUCUAGUGCAGAUA...................................................... 1 1 hsa-mir-18a_L10 ESC_DGCR8_454 .............CUAAGGUGCAUCUAGUGCAGAU....................................................... 1 1 hsa-mir-18a_L11 ESC_WT_454 .......................................................ACUGCCCUAAGUGCUCCUUCUGG............ 6 1 hsa-mir-18a_R01*_M ESC_WT_454 .......................................................ACUGCCCUAAGUGCUCCUUCUGGC........... 2 1 hsa-mir-18a_R02* ESC_WT_454 .......................................................ACUGCCCUAAGUGCUCCUUCUG............. 1 1 hsa-mir-18a_R03* ESC_WT_454 ......................................................UACUGCCCUAAGUGCUCCUUCUGG............ 1 1 hsa-mir-18a_R04* ESC_WT_454 hsa-mir-18b chrX:133131717-133131827 - UCUUAUAAUGUGUCUCUUGUGUUAAGGUGCAUCUAGUGCAGUUAGUGAAGCAGCUUAGAAUCUACUGCCCUAAAUGCCCCUUCUGGCACAGGCUGCC ...........((..((((((((((((.((((.(((.(((((..((.(((...)))...))..))))).))).)))).)))..)))))))))..)). (-28.80) ......................UAAGGUGCAUCUAGUGCAG........................................................ 6 2 hsa-mir-18b_L01*_M ESC_WT_454 ......................UAAGGUGCAUCUAGUGCA......................................................... 3 2 hsa-mir-18b_L02* ESC_WT_454 ..............................................................UACUGCCCUAAAUGCCCCUUCU............. 38 1 hsa-mir-18b_R01_M ESC_WT_454 ..............................................................UACUGCCCUAAAUGCCCCUUC.............. 1 1 hsa-mir-18b_R02 ESC_DGCR8_454 .............................................................CUACUGCCCUAAAUGCCCCUUC.............. 1 1 hsa-mir-18b_R03 ESC_WT_454 ..............................................................UACUGCCCUAAAUGCCCCUUC.............. 1 1 hsa-mir-18b_R04 ESC_WT_454 ..............................................................UACUGCCCUAAAUGCCCCU................ 1 1 hsa-mir-18b_R05 ESC_WT_454 .............................................................CUACUGCCCUAAAUGCCCCUUCU............. 1 1 hsa-mir-18b_R06 ESC_WT_454 hsa-mir-190 chr15:60903189-60903313 + UGCCUUUUCUGCAGGCCUCUGUGUGAUAUGUUUGAUAUAUUAGGUUGUUAUUUAAUCCAACUAUAUAUCAAACAUAUUCCUACAGUGUCUUGCCCUGUCUCCGG ..........(((((.(.(((((..(((((((((((((((..(((((..........))))))))))))))))))))..).)))).).)))))........... (-32.50) .......................UGAUAUGUUUGAUAUAUUAGGUU.......................................................... 6 1 hsa-mir-190_L01_M ESC_WT_454 .......................UGAUAUGUUUGAUAUAUUAGGU........................................................... 4 1 hsa-mir-190_L02 ESC_WT_454 .......................UGAUAUGUUUGAUAUAUUAGGUUG......................................................... 1 1 hsa-mir-190_L03 ESC_WT_454 hsa-mir-190b chr1:152432745-152432863 - CUCUCCUGCCUGCUUCUGUGUGAUAUGUUUGAUAUUGGGUUGUUUAAUUAGGAACCAACUAAAUGUCAAACAUAUUCUUACAGCAGCAGGUGAUUCAG .......(((((((.(((((.(((((((((((((((.((((((((......))).))))).)))))))))))))))..))))).)))))))....... (-40.60) ....................UGAUAUGUUUGAUAUUGGGU.......................................................... 1 1 hsa-mir-190b_L01_M ESC_WT_454 hsa-mir-191 chr3:49033035-49033166 - CCCCCGCCAACGGCUGGACAGCGGGCAACGGAAUCCCAAAAGCAGCUGUUGUCUCCAGAGCAUUCCAGCUGCGCUUGGAUUUCGUCCCCUGCUCUCCUGCCUGAGCAGCGC .....((((..(((.(((.((((((..(((((((((.((..(((((((..((((....)).))..)))))))..)))))))))))..)))))).))).))))).))..... (-51.20) .........................CAACGGAAUCCCAAAAGCAGCUG............................................................... 37 1 hsa-mir-191_L01_M ESC_WT_454 .........................CAACGGAAUCCCAAAAGCAGCU................................................................ 20 1 hsa-mir-191_L02 ESC_WT_454 .........................CAACGGAAUCCCAAAAGCAGCUGU.............................................................. 13 1 hsa-mir-191_L03 ESC_WT_454 .........................CAACGGAAUCCCAAAAGCAGC................................................................. 4 1 hsa-mir-191_L04 ESC_WT_454 .........................CAACGGAAUCCCAAAAGCAG.................................................................. 3 1 hsa-mir-191_L05 ESC_WT_454 .........................CAACGGAAUCCCAAAAGCA................................................................... 1 1 hsa-mir-191_L06 ESC_WT_454 hsa-mir-192 chr11:64415165-64415314 - UCGGUGGGCUGCCGAGACCGAGUGCACAGGGCUCUGACCUAUGAAUUGACAGCCAGUGCUCUCGUCUCCCCUCUGGCUGCCAAUUCCAUAGGUCACAGGUAUGUUCGCCUCAAUGCCAGCCACCAGGAC ..(((((.(((.((.....(((.(((((.(.((.((((((((((((((.(((((((................))))))).))))).))))))))).)).).)))..)))))..)).))))))))..... (-50.79) .................................CUGACCUAUGAAUUGACAGCC........................................................................... 18 1 hsa-mir-192_L01_M ESC_WT_454 .................................CUGACCUAUGAAUUGACAGCCA.......................................................................... 12 1 hsa-mir-192_L02 ESC_WT_454 .................................CUGACCUAUGAAUUGACAGC............................................................................ 9 1 hsa-mir-192_L03 ESC_WT_454 ..................................UGACCUAUGAAUUGACAGCC........................................................................... 4 1 hsa-mir-192_L04 ESC_WT_454 ..................................UGACCUAUGAAUUGACAGCCAG......................................................................... 1 1 hsa-mir-192_L05 ESC_WT_454 .................................CUGACCUAUGAAUUGACAG............................................................................. 1 1 hsa-mir-192_L06 ESC_WT_454 hsa-mir-193a chr17:26911108-26911235 + CGCACCCCGAACUCCGAGGAUGGGAGCUGAGGGCUGGGUCUUUGCGGGCGAGAUGAGGGUGUCGGAUCAACUGGCCUACAAAGUCCCAGUUCUCGGCCCCCGGGACCAGCGU (((..((((...((....)).(((.(((((((((((((.(((((..(((.((.(((..........))).)).)))..))))).))))))))))))))))))))....))). (-57.70) ....................................................................AACUGGCCUACAAAGUCCCAGU...................... 5 1 hsa-mir-193a_R01_M ESC_WT_454 hsa-mir-194-1 chr1:218358102-218358226 - UAUAUGUUUAAUGGUGUUAUCAAGUGUAACAGCAACUCCAUGUGGACUGUGUACCAAUUUCCAGUGGAGAUGCUGUUACUUUUGAUGGUUACCAACUUGCUACA .....((....(((((..((((((.(((((((((.((((((.((((..((......)).)))))))))).))))))))).))))))..).))))....)).... (-38.40) ........................UGUAACAGCAACUCCAUGUGGA.......................................................... 7 2 hsa-mir-194-1_L01_M ESC_WT_454 hsa-mir-194-2 chr11:64415383-64415507 - CCCCGGUCUCCAAUUGGUUCCCGCCCCCUGUAACAGCAACUCCAUGUGGAAGUGCCCACUGGUUCCAGUGGGGCUGCUGUUAUCUGGGGCGAGGGCCAGUACCCACGA ....(((.....((((((((.((((((..(((((((((..(((....)))....(((((((....)))))))..)))))))))..)))))).)))))))))))..... (-54.60) ............................UGUAACAGCAACUCCAUGUGGA.......................................................... 7 2 hsa-mir-194-2_L01_M ESC_WT_454 ............................UGUAACAGCAACUCCAUGUGGAA......................................................... 3 1 hsa-mir-194-2_L02 ESC_WT_454 hsa-mir-195 chr17:6861638-6861764 - GCCCACACCCAGCUUCCCUGGCUCUAGCAGCACAGAAAUAUUGGCACAGGGAAGCGAGUCUGCCAAUAUUGGCUGUGCUGCUCCAGGCAGGGUGGUGAAAACUACC .....((((......(((((.((..((((((((((.((((((((((..............))))))))))..))))))))))..)).))))).))))......... (-47.64) ........................UAGCAGCACAGAAAUAUUGGCA............................................................ 25 1 hsa-mir-195_L01_M ESC_WT_454 .......................CUAGCAGCACAGAAAUAUUGGC............................................................. 1 1 hsa-mir-195_L02 ESC_WT_454 hsa-mir-196a-1 chr17:44064831-44064940 - GAACUGCUGAGUGAAUUAGGUAGUUUCAUGUUGUUGGGCCUGGGUUUCUGAACACAACAACAUUAAACCACCCGAUUCACGGCAGUUAC .(((((((..((((((..(((.((((.((((((((((..(.........)..).))))))))).)))).)))..))))))))))))).. (-35.90) ................UAGGUAGUUUCAUGUUGUUGGG................................................... 44 2 hsa-mir-196a-1_L01_M ESC_WT_454 .................AGGUAGUUUCAUGUUGUUGGGC.................................................. 3 1 hsa-mir-196a-1_L02 ESC_WT_454 ................UAGGUAGUUUCAUGUUGUUGG.................................................... 2 2 hsa-mir-196a-1_L03 ESC_WT_454 .................AGGUAGUUUCAUGUUGUUGGG................................................... 1 2 hsa-mir-196a-1_L04 ESC_WT_454 hsa-mir-196a-2 chr12:52671769-52671918 + CUCCCGCCCUGCUCGCUCAGCUGAUCUGUGGCUUAGGUAGUUUCAUGUUGUUGGGAUUGAGUUUUGAACUCGGCAACAAGAAACUGCCUGAGUUACAUCAGUCGGUUUUCGUCGAGGGCCCCAACCCAC .....(((((...((...(((((((.((((((((((((((((((.((((((((((.(..(...)..).)))))))))).))))))))))))))))))...)))))))..))...))))).......... (-56.80) .................................UAGGUAGUUUCAUGUUGUUGGG.......................................................................... 44 2 hsa-mir-196a-2_L01_M ESC_WT_454 .................................UAGGUAGUUUCAUGUUGUUGG........................................................................... 2 2 hsa-mir-196a-2_L02 ESC_WT_454 ..................................AGGUAGUUUCAUGUUGUUGGG.......................................................................... 1 2 hsa-mir-196a-2_L03 ESC_WT_454 hsa-mir-196b chr7:27175604-27175727 - CAGCACCAGAACUGGUCGGUGAUUUAGGUAGUUUCCUGUUGUUGGGAUCCACCUUUCUCUCGACAGCACGACACUGCCUUCAUUACUUCAGUUGAAAUCGUCU .........((((((..((((((..(((((((.((.(((((((((((..........))))))))))).)).)))))))..)))))))))))).......... (-36.20) ........................UAGGUAGUUUCCUGUUGUUGGG......................................................... 13 1 hsa-mir-196b_L01_M ESC_WT_454 hsa-mir-199a-1 chr19:10789082-10789192 - AGCCGGCCCCGCCAACCCAGUGUUCAGACUACCUGUUCAGGAGGCUCUCAAUGUGUACAGUAGUCUGCACAUUGGUUAGGCUGGGCUUGGG ..(((((((.(((...(((((((.((((((((.(((.((.(((...)))....)).))))))))))).)))))))...))).)))).))). (-43.30) ...............CCCAGUGUUCAGACUACCUGUUC..................................................... 1 2 hsa-mir-199a-1_L01*_M ESC_WT_454 ...............CCCAGUGUUCAGACUACCUGUU...................................................... 1 2 hsa-mir-199a-1_L02* ESC_WT_454 ........................................................ACAGUAGUCUGCACAUUGGUU.............. 11 3 hsa-mir-199a-1_R01_M ESC_WT_454 .......................................................UACAGUAGUCUGCACAUUGGUU.............. 9 3 hsa-mir-199a-1_R02 ESC_WT_454 .........................................................CAGUAGUCUGCACAUUGGUUA............. 2 3 hsa-mir-199a-1_R03 ESC_WT_454 .......................................................UACAGUAGUCUGCACAUUGGU............... 1 3 hsa-mir-199a-1_R04 ESC_WT_454 ........................................................ACAGUAGUCUGCACAUUGGUUA............. 1 3 hsa-mir-199a-1_R05 ESC_WT_454 hsa-mir-199a-2 chr1:170380278-170380427 - AGUACAUAGAAGGAAGCUUCUGGAGAUCCUGCUCCGUCGCCCCAGUGUUCAGACUACCUGUUCAGGACAAUGCCGUUGUACAGUAGUCUGCACAUUGGUUAGACUGGGCAAGGGAGAGCAACGCCAUGG .((...((((((....))))))....((((((((.(((...(((((((.((((((((.(((...((......)).....))))))))))).)))))))...))).)))).))))...)).......... (-47.40) ........................................CCCAGUGUUCAGACUACCUGUUC.................................................................. 1 2 hsa-mir-199a-2_L01*_M ESC_WT_454 ........................................CCCAGUGUUCAGACUACCUGUU................................................................... 1 2 hsa-mir-199a-2_L02* ESC_WT_454 ...............................................................................ACAGUAGUCUGCACAUUGGUU............................. 11 3 hsa-mir-199a-2_R01_M ESC_WT_454 ..............................................................................UACAGUAGUCUGCACAUUGGUU............................. 9 3 hsa-mir-199a-2_R02 ESC_WT_454 ................................................................................CAGUAGUCUGCACAUUGGUUA............................ 2 3 hsa-mir-199a-2_R03 ESC_WT_454 ..............................................................................UACAGUAGUCUGCACAUUGGU.............................. 1 3 hsa-mir-199a-2_R04 ESC_WT_454 ...............................................................................ACAGUAGUCUGCACAUUGGUUA............................ 1 3 hsa-mir-199a-2_R05 ESC_WT_454 hsa-mir-199b chr9:130046801-130046950 - GCCUGGAUGGACCAGAGGACACCUCCACUCCGUCUACCCAGUGUUUAGACUAUCUGUUCAGGACUCCCAAAUUGUACAGUAGUCUGCACAUUGGUUAGGCUGGGCUGGGUUAGACCCUCGGCACCGCCGCCA ...((((((((...((((...))))...)))))))).(((((((.(((((((.((((.((((....))....)).))))))))))).)))))))...(((.((((((((.......)))))).))))).... (-51.70) ...........................................................................ACAGUAGUCUGCACAUUGGUU.................................... 11 3 hsa-mir-199b_R01_M ESC_WT_454 ..........................................................................UACAGUAGUCUGCACAUUGGUU.................................... 9 3 hsa-mir-199b_R02 ESC_WT_454 ............................................................................CAGUAGUCUGCACAUUGGUUA................................... 2 3 hsa-mir-199b_R03 ESC_WT_454 ..........................................................................UACAGUAGUCUGCACAUUGGU..................................... 1 3 hsa-mir-199b_R04 ESC_WT_454 ...........................................................................ACAGUAGUCUGCACAUUGGUUA................................... 1 3 hsa-mir-199b_R05 ESC_WT_454 hsa-mir-19a chr13:90801126-90801247 + AGUUUUUGUUUGCAGUCCUCUGUUAGUUUUGCAUAGUUGCACUACAAGAAGAAUGUAGUUGUGCAAAUCUAUGCAAAACUGAUGGUGGCCUGCUAUUUCCUUC ...........((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).)))).......... (-40.30) ........................AGUUUUGCAUAGUUGCACUAC.......................................................... 3 1 hsa-mir-19a_L01*_M ESC_WT_454 .......................UAGUUUUGCAUAGUUGCACUAC.......................................................... 1 1 hsa-mir-19a_L02* ESC_WT_454 .......................UAGUUUUGCAUAGUUGCACUACA......................................................... 1 1 hsa-mir-19a_L03* ESC_WT_454 ...........................................................UGUGCAAAUCUAUGCAAAACUGA..................... 224 1 hsa-mir-19a_R01_M ESC_WT_454 ...........................................................UGUGCAAAUCUAUGCAAAACUG...................... 154 1 hsa-mir-19a_R02 ESC_WT_454 ...........................................................UGUGCAAAUCUAUGCAAAACUGAU.................... 19 1 hsa-mir-19a_R03 ESC_WT_454 ...........................................................UGUGCAAAUCUAUGCAAAACU....................... 3 1 hsa-mir-19a_R04 ESC_WT_454 ..........................................................UUGUGCAAAUCUAUGCAAAACUG...................... 3 1 hsa-mir-19a_R05 ESC_WT_454 .....................................................UGUAGUUGUGCAAAUCUAUGCA............................ 2 1 hsa-mir-19a_R06 ESC_WT_454 ...........................................................UGUGCAAAUCUAUGCAAAACUG...................... 1 1 hsa-mir-19a_R07 ESC_DGCR8_454 ..........................................................UUGUGCAAAUCUAUGCAAAACUGA..................... 1 1 hsa-mir-19a_R08 ESC_WT_454 ...............................................................CAAAUCUAUGCAAAACUG...................... 1 1 hsa-mir-19a_R09 ESC_WT_454 hsa-mir-19b-1 chr13:90801427-90801553 + GUUACUGAACACUGUUCUAUGGUUAGUUUUGCAGGUUUGCAUCCAGCUGUGUGAUAUUCUGCUGUGCAAAUCCAUGCAAAACUGACUGUGGUAGUGAAAAGUCUGU ...(((...(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))...))).... (-40.92) ........................AGUUUUGCAGGUUUGCAUCCAGCU.......................................................... 3 1 hsa-mir-19b-1_L01*_M ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAAACUGA..................... 1448 2 hsa-mir-19b-1_R01_M ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAAACUG...................... 985 2 hsa-mir-19b-1_R02 ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAAACU....................... 17 2 hsa-mir-19b-1_R03 ESC_WT_454 .............................................................CUGUGCAAAUCCAUGCAAAACUG...................... 7 2 hsa-mir-19b-1_R04 ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAAACUGA..................... 6 2 hsa-mir-19b-1_R05 ESC_DGCR8_454 ..............................................................UGUGCAAAUCCAUGCAAAACUGAC.................... 6 1 hsa-mir-19b-1_R06 ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAAACUG...................... 5 2 hsa-mir-19b-1_R07 ESC_DGCR8_454 ..............................................................UGUGCAAAUCCAUGCAAAAC........................ 5 2 hsa-mir-19b-1_R08 ESC_WT_454 .............................................................CUGUGCAAAUCCAUGCAAAACU....................... 2 2 hsa-mir-19b-1_R09 ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAAA......................... 2 2 hsa-mir-19b-1_R10 ESC_WT_454 .............................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 2 2 hsa-mir-19b-1_R11 ESC_WT_454 ..............................................................UGUGCAAAUCCAUGCAAA.......................... 1 2 hsa-mir-19b-1_R12 ESC_WT_454 ...................................................................AAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-1_R13 ESC_WT_454 .................................................................GCAAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-1_R14 ESC_WT_454 hsa-mir-19b-2 chrX:133131347-133131482 - GAUGGAGAGAAUAUUCAAAGACAUUGCUACUUACAAUUAGUUUUGCAGGUUUGCAUUUCAGCGUAUAUAUGUAUAUGUGGCUGUGCAAAUCCAUGCAAAACUGAUUGUGAUAAUGUGUGCUUCCU ...((((.((....))..(.((((((....((((((((((((((((((((((((((....(((((((....)))))))....))))))).)).))))))))))))))))))))))).)..)))). (-44.10) .................................................................................UGUGCAAAUCCAUGCAAAACUGA..................... 1448 2 hsa-mir-19b-2_R01_M ESC_WT_454 .................................................................................UGUGCAAAUCCAUGCAAAACUG...................... 985 2 hsa-mir-19b-2_R02 ESC_WT_454 .................................................................................UGUGCAAAUCCAUGCAAAACU....................... 17 2 hsa-mir-19b-2_R03 ESC_WT_454 .................................................................................UGUGCAAAUCCAUGCAAAACUGAU.................... 11 1 hsa-mir-19b-2_R04 ESC_WT_454 ................................................................................CUGUGCAAAUCCAUGCAAAACUG...................... 7 2 hsa-mir-19b-2_R05 ESC_WT_454 .................................................................................UGUGCAAAUCCAUGCAAAACUGA..................... 6 2 hsa-mir-19b-2_R06 ESC_DGCR8_454 .................................................................................UGUGCAAAUCCAUGCAAAACUG...................... 5 2 hsa-mir-19b-2_R07 ESC_DGCR8_454 .................................................................................UGUGCAAAUCCAUGCAAAAC........................ 5 2 hsa-mir-19b-2_R08 ESC_WT_454 ................................................................................CUGUGCAAAUCCAUGCAAAACU....................... 2 2 hsa-mir-19b-2_R09 ESC_WT_454 .................................................................................UGUGCAAAUCCAUGCAAAA......................... 2 2 hsa-mir-19b-2_R10 ESC_WT_454 ................................................................................CUGUGCAAAUCCAUGCAAAACUGA..................... 2 2 hsa-mir-19b-2_R11 ESC_WT_454 .................................................................................UGUGCAAAUCCAUGCAAAACUGAU.................... 1 1 hsa-mir-19b-2_R12 ESC_DGCR8_454 .................................................................................UGUGCAAAUCCAUGCAAA.......................... 1 2 hsa-mir-19b-2_R13 ESC_WT_454 ......................................................................................AAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-2_R14 ESC_WT_454 ....................................................................................GCAAAUCCAUGCAAAACUGA..................... 1 2 hsa-mir-19b-2_R15 ESC_WT_454 hsa-mir-200a chr1:1093086-1093215 + ACGUCCCUCCCGGGCCCCUGUGAGCAUCUUACCGGACAGUGCUGGAUUUCCCAGCUUGACUCUAACACUGUCUGGUAACGAUGUUCAAAGGUGACCCGCCGCUCGCCGGGGACA ..((((((..(((((((((.(((((((((((((((((((((((((.....)))))...........)))))))))))).)))))))).))).).......)))))..)))))). (-56.41) ........................CAUCUUACCGGACAGUGCUGGA.................................................................... 1 1 hsa-mir-200a_L01*_M ESC_DGCR8_454 ........................CAUCUUACCGGACAGUGCUGGA.................................................................... 1 1 hsa-mir-200a_L02* ESC_WT_454 ..............................................................UAACACUGUCUGGUAACGAUGUU............................. 101 1 hsa-mir-200a_R01_M ESC_WT_454 ..............................................................UAACACUGUCUGGUAACGAUGU.............................. 31 1 hsa-mir-200a_R02 ESC_WT_454 ..................................................................ACUGUCUGGUAACGAUGUU............................. 5 1 hsa-mir-200a_R03 ESC_WT_454 ..............................................................UAACACUGUCUGGUAACGAUG............................... 2 1 hsa-mir-200a_R04 ESC_WT_454 .................................................................CACUGUCUGGUAACGAUGUU............................. 2 1 hsa-mir-200a_R05 ESC_WT_454 ..............................................................UAACACUGUCUGGUAACGAUGUU............................. 1 1 hsa-mir-200a_R06 ESC_DGCR8_454 ..............................................................UAACACUGUCUGGUAACGAU................................ 1 1 hsa-mir-200a_R07 ESC_WT_454 .............................................................CUAACACUGUCUGGUAACGAUGUU............................. 1 1 hsa-mir-200a_R08 ESC_WT_454 ..............................................................UAACACUGUCUGGUAACGAUGUUC............................ 1 1 hsa-mir-200a_R09 ESC_WT_454 hsa-mir-200b chr1:1092327-1092461 + GGGCGGCCCCCGGACCCAGCUCGGGCAGCCGUGGCCAUCUUACUGGGCAGCAUUGGAUGGAGUCAGGUCUCUAAUACUGCCUGGUAAUGAUGACGGCGGAGCCCUGCACGCAGCGACCGG (((...)))((((.....(((((.((((((((.(.((((((((..(((((.((((((.((.......)))))))).)))))..)))).)))).).))))....)))).)).)))..)))) (-50.20) ...................................CAUCUUACUGGGCAGCAUUGGA............................................................... 3 1 hsa-mir-200b_L01*_M ESC_WT_454 .......................................................................UAAUACUGCCUGGUAAUGAUGAC.......................... 1352 1 hsa-mir-200b_R01_M ESC_WT_454 .......................................................................UAAUACUGCCUGGUAAUGAUGA........................... 454 1 hsa-mir-200b_R02 ESC_WT_454 .......................................................................UAAUACUGCCUGGUAAUGAUG............................ 83 1 hsa-mir-200b_R03 ESC_WT_454 .......................................................................UAAUACUGCCUGGUAAUGAUGAC.......................... 13 1 hsa-mir-200b_R04 ESC_DGCR8_454 ........................................................................AAUACUGCCUGGUAAUGAUGAC.......................... 8 1 hsa-mir-200b_R05 ESC_WT_454 ..........................................................................UACUGCCUGGUAAUGAUGAC.......................... 8 1 hsa-mir-200b_R06 ESC_WT_454 .........................................................................AUACUGCCUGGUAAUGAUGAC.......................... 6 1 hsa-mir-200b_R07 ESC_WT_454 ...........................................................................ACUGCCUGGUAAUGAUGAC.......................... 4 1 hsa-mir-200b_R08 ESC_WT_454 ..........................................................................UACUGCCUGGUAAUGAUGA........................... 4 1 hsa-mir-200b_R09 ESC_WT_454 ......................................................................CUAAUACUGCCUGGUAAUGAUGAC.......................... 2 1 hsa-mir-200b_R10 ESC_DGCR8_454 .......................................................................UAAUACUGCCUGGUAAUGAUG............................ 2 1 hsa-mir-200b_R11 ESC_DGCR8_454 ......................................................................CUAAUACUGCCUGGUAAUGAUGAC.......................... 2 1 hsa-mir-200b_R12 ESC_WT_454 .......................................................................UAAUACUGCCUGGUAAUGAUGA........................... 1 1 hsa-mir-200b_R13 ESC_DGCR8_454 .........................................................................AUACUGCCUGGUAAUGAUGA........................... 1 1 hsa-mir-200b_R14 ESC_WT_454 ......................................................................CUAAUACUGCCUGGUAAUGAUGA........................... 1 1 hsa-mir-200b_R15 ESC_WT_454 ........................................................................AAUACUGCCUGGUAAUGAUGA........................... 1 1 hsa-mir-200b_R16 ESC_WT_454 ............................................................................CUGCCUGGUAAUGAUGAC.......................... 1 1 hsa-mir-200b_R17 ESC_WT_454 .......................................................................UAAUACUGCCUGGUAAUGAUGACG......................... 1 1 hsa-mir-200b_R18 ESC_WT_454 hsa-mir-200c chr12:6943103-6943210 + GGGCGGGGGCCCUCGUCUUACCCAGCAGUGUUUGGGUGCGGUUGGGAGUCUCUAAUACUGCCGGGUAAUGAUGGAGGCCCCUGUCCC (((((((((((..((((((((((.((((((((.(((.((........))))).)))))))).)))))).))))..))))))))))). (-56.20) ....................................................UAAUACUGCCGGGUAAUGAUGGA............ 1046 1 hsa-mir-200c_R01_M ESC_WT_454 ....................................................UAAUACUGCCGGGUAAUGAUGG............. 477 1 hsa-mir-200c_R02 ESC_WT_454 ....................................................UAAUACUGCCGGGUAAUGAUGGA............ 16 1 hsa-mir-200c_R03 ESC_DGCR8_454 ...................................................CUAAUACUGCCGGGUAAUGAUGGA............ 13 1 hsa-mir-200c_R04 ESC_WT_454 ....................................................UAAUACUGCCGGGUAAUGAUG.............. 11 1 hsa-mir-200c_R05 ESC_WT_454 ....................................................UAAUACUGCCGGGUAAUGAUGG............. 7 1 hsa-mir-200c_R06 ESC_DGCR8_454 ...................................................CUAAUACUGCCGGGUAAUGAUGG............. 6 1 hsa-mir-200c_R07 ESC_WT_454 .....................................................AAUACUGCCGGGUAAUGAUGGA............ 5 1 hsa-mir-200c_R08 ESC_WT_454 .........................................................CUGCCGGGUAAUGAUGGA............ 5 1 hsa-mir-200c_R09 ESC_WT_454 .......................................................UACUGCCGGGUAAUGAUGGA............ 4 1 hsa-mir-200c_R10 ESC_WT_454 ...................................................CUAAUACUGCCGGGUAAUGAUG.............. 3 1 hsa-mir-200c_R11 ESC_WT_454 ........................................................ACUGCCGGGUAAUGAUGG............. 3 1 hsa-mir-200c_R12 ESC_WT_454 .....................................................AAUACUGCCGGGUAAUGAUGG............. 2 1 hsa-mir-200c_R13 ESC_WT_454 ......................................................AUACUGCCGGGUAAUGAUGGA............ 2 1 hsa-mir-200c_R14 ESC_WT_454 ......................................................AUACUGCCGGGUAAUGAUGG............. 2 1 hsa-mir-200c_R15 ESC_WT_454 .......................................................UACUGCCGGGUAAUGAUG.............. 1 1 hsa-mir-200c_R16 ESC_WT_454 ........................................................ACUGCCGGGUAAUGAUGGA............ 1 1 hsa-mir-200c_R17 ESC_WT_454 hsa-mir-203 chr14:103653475-103653624 + GAACCGACGGUGUUGGGGACUCGCGCGCUGGGUCCAGUGGUUCUUAACAGUUCAACAGUUCUGUAGCGCAAUUGUGAAAUGUUUAGGACCACUAGACCCGGCGGGCGCGGCGACAGCGACGGAGCGUCC ...(((.((.(((((....(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).))))).)).)))....... (-63.50) ..........................................................................UGAAAUGUUUAGGACCACUAG.................................. 1 1 hsa-mir-203_R01_M ESC_WT_454 hsa-mir-205 chr1:207672081-207672230 + CCCUCUGAGAAAAAGAUCCUCAGACAAUCCAUGUGCUUCUCUUGUCCUUCAUUCCACCGGAGUCUGUCUCAUACCCAACCAGAUUUCAGUGGAGUGAAGUUCAGGAGGCAUGGAGCUGACAACCAUGAGGCC .((((((.((......)).((((....(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))).))))....)).)))).. (-52.72) ............................................UCCUUCAUUCCACCGGAGUCUG.................................................................. 6 1 hsa-mir-205_L01_M ESC_WT_454 hsa-mir-206 chr6:52117086-52117211 + GCUUCUGGAUGACACUGCUUCCCGAGGCCACAUGCUUCUUUAUAUCCCCAUAUGGAUUACUUUGCUAUGGAAUGUAAGGAAGUGUGUGGUUUCGGCAAGUGCCUCCUCGCU ((....(((.(.((((.....((((((((((((((((((((((((..(((((.(.(......).)))))).))))))))))))))))))))))))..))))).)))..)). (-48.70) ...................................................................UGGAAUGUAAGGAAGUGUGUGG...................... 1 1 hsa-mir-206_R01_M ESC_WT_454 hsa-mir-208a chr14:22927625-22927735 - CCACUUCCUGUGACGGGCGAGCUUUUGGCCCGGGUUAUACCUGAUGCUCACGUAUAAGACGAGCAAAAAGCUUGUUGGUCAGAGGAGCUA ....(((((.((((.(((((((((((.((.((..((((((.((.....)).))))))..)).)).))))))))))).)))).)))))... (-41.90) .....................................................AUAAGACGAGCAAAAAGCUUGU............... 1 1 hsa-mir-208a_R01_M ESC_WT_454 hsa-mir-20a chr13:90801300-90801410 + GACAGCUUCUGUAGCACUAAAGUGCUUAUAGUGCAGGUAGUGUUUAGUUAUCUACUGCAUUAUGAGCACUUAAAGUACUGCUAGCUGUAGA .((((((...((((.(((.(((((((((((((((((.(((((......)).))))))))))))))))))))..))).)))).))))))... (-41.50) .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 822 1 hsa-mir-20a_L01_M ESC_WT_454 .................UAAAGUGCUUAUAGUGCAGGUA.................................................... 162 1 hsa-mir-20a_L02 ESC_WT_454 .................UAAAGUGCUUAUAGUGCAGGU..................................................... 48 1 hsa-mir-20a_L03 ESC_WT_454 .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 23 1 hsa-mir-20a_L04 ESC_DGCR8_454 .................UAAAGUGCUUAUAGUGCAGGUAGU.................................................. 21 1 hsa-mir-20a_L05 ESC_WT_454 .................UAAAGUGCUUAUAGUGCAG....................................................... 12 1 hsa-mir-20a_L06 ESC_WT_454 .................UAAAGUGCUUAUAGUGCAGG...................................................... 8 1 hsa-mir-20a_L07 ESC_WT_454 .................UAAAGUGCUUAUAGUGCAGGUA.................................................... 2 1 hsa-mir-20a_L08 ESC_DGCR8_454 ................CUAAAGUGCUUAUAGUGCAGGUA.................................................... 2 1 hsa-mir-20a_L09 ESC_WT_454 ................CUAAAGUGCUUAUAGUGCAGGUAG................................................... 2 1 hsa-mir-20a_L10 ESC_WT_454 .................UAAAGUGCUUAUAGUGCAGGU..................................................... 1 1 hsa-mir-20a_L11 ESC_DGCR8_454 .................UAAAGUGCUUAUAGUGCAGGUAGU.................................................. 1 1 hsa-mir-20a_L12 ESC_DGCR8_454 .................UAAAGUGCUUAUAGUGCAGG...................................................... 1 1 hsa-mir-20a_L13 ESC_DGCR8_454 ..................AAAGUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L14 ESC_WT_454 ....................AGUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L15 ESC_WT_454 hsa-mir-20b chrX:133131485-133131593 - GAUAAGAUUGGGUCCUAGUAGUACCAAAGUGCUCAUAGUGCAGGUAGUUUUGGCAUGACUCUACUGUAGUAUGGGCACUUCCAGUACUCUUGGAUAA ...........((((.((.(((((..(((((((((((.(((((..((((.......))))...))))).)))))))))))...))))))).)))).. (-37.60) ........................CAAAGUGCUCAUAGUGCAGGUAG.................................................. 1552 1 hsa-mir-20b_L01_M ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGUA................................................... 191 1 hsa-mir-20b_L02 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGUAGU................................................. 75 1 hsa-mir-20b_L03 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGU.................................................... 67 1 hsa-mir-20b_L04 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGUAG.................................................. 19 1 hsa-mir-20b_L05 ESC_DGCR8_454 .......................CCAAAGUGCUCAUAGUGCAGGUAG.................................................. 11 1 hsa-mir-20b_L06 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGG..................................................... 7 1 hsa-mir-20b_L07 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGUA................................................... 6 1 hsa-mir-20b_L08 ESC_DGCR8_454 ........................CAAAGUGCUCAUAGUGCAG...................................................... 6 1 hsa-mir-20b_L09 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGUAGU................................................. 4 1 hsa-mir-20b_L10 ESC_DGCR8_454 .............................UGCUCAUAGUGCAGGUAG.................................................. 4 1 hsa-mir-20b_L11 ESC_WT_454 ........................CAAAGUGCUCAUAGUGCAGGU.................................................... 2 1 hsa-mir-20b_L12 ESC_DGCR8_454 .......................CCAAAGUGCUCAUAGUGCAGGUAG.................................................. 2 1 hsa-mir-20b_L13 ESC_DGCR8_454 .........................AAAGUGCUCAUAGUGCAGGUAG.................................................. 2 1 hsa-mir-20b_L14 ESC_WT_454 hsa-mir-21 chr17:55273389-55273500 + GUACCACCUUGUCGGGUAGCUUAUCAGACUGAUGUUGACUGUUGAAUCUCAUGGCAACACCAGUCGAUGGGCUGUCUGACAUUUUGGUAUC ((((((...((((((..((((((((.(((((.(((((.((((.(.....)))))))))).)))))))))))))..))))))...)))))). (-43.40) ................UAGCUUAUCAGACUGAUGUUGAC.................................................... 10307 1 hsa-mir-21_L01_M ESC_WT_454 ................UAGCUUAUCAGACUGAUGUUGA..................................................... 8509 1 hsa-mir-21_L02 ESC_WT_454 ................UAGCUUAUCAGACUGAUGUUG...................................................... 679 1 hsa-mir-21_L03 ESC_WT_454 ................UAGCUUAUCAGACUGAUGUUGACU................................................... 257 1 hsa-mir-21_L04 ESC_WT_454 ................UAGCUUAUCAGACUGAUGUUGAC.................................................... 198 1 hsa-mir-21_L05 ESC_DGCR8_454 ................UAGCUUAUCAGACUGAUGUUGA..................................................... 96 1 hsa-mir-21_L06 ESC_DGCR8_454 .................AGCUUAUCAGACUGAUGUUGAC.................................................... 33 1 hsa-mir-21_L07 ESC_WT_454 .................AGCUUAUCAGACUGAUGUUGA..................................................... 24 1 hsa-mir-21_L08 ESC_WT_454 ....................UUAUCAGACUGAUGUUGA..................................................... 19 1 hsa-mir-21_L09 ESC_WT_454 ....................UUAUCAGACUGAUGUUGAC.................................................... 15 1 hsa-mir-21_L10 ESC_WT_454 ................UAGCUUAUCAGACUGAUGUUG...................................................... 9 1 hsa-mir-21_L11 ESC_DGCR8_454 ...................CUUAUCAGACUGAUGUUGAC.................................................... 9 1 hsa-mir-21_L12 ESC_WT_454 ...................CUUAUCAGACUGAUGUUGA..................................................... 8 1 hsa-mir-21_L13 ESC_WT_454 .....................UAUCAGACUGAUGUUGAC.................................................... 6 1 hsa-mir-21_L14 ESC_WT_454 ................UAGCUUAUCAGACUGAUGUU....................................................... 6 1 hsa-mir-21_L15 ESC_WT_454 ..................GCUUAUCAGACUGAUGUUGAC.................................................... 4 1 hsa-mir-21_L16 ESC_WT_454 ...............GUAGCUUAUCAGACUGAUGUUGAC.................................................... 3 1 hsa-mir-21_L17 ESC_WT_454 .................AGCUUAUCAGACUGAUGUUGACU................................................... 2 1 hsa-mir-21_L18 ESC_WT_454 ................UAGCUUAUCAGACUGAUG......................................................... 1 1 hsa-mir-21_L19 ESC_WT_454 ...............GUAGCUUAUCAGACUGAUGUUG...................................................... 1 1 hsa-mir-21_L20 ESC_WT_454 ...................CUUAUCAGACUGAUGUUG...................................................... 1 1 hsa-mir-21_L21 ESC_WT_454 ...................CUUAUCAGACUGAUGUUGACU................................................... 1 1 hsa-mir-21_L22 ESC_WT_454 hsa-mir-210 chr11:558069-558218 - UCCCUCCGCCCGCCCACCCGGCAGUGCCUCCAGGCGCAGGGCAGCCCCUGCCCACCGCACACUGCGCUGCCCCAGACCCACUGUGCGUGUGACAGCGGCUGAUCUGUGCCUGGGCAGCGCGACCCUCCUGGCCCC .......(((.(((.....))).((((.(((((((((((..(((((.(((..(((((((((.((.((((...))).).)).)))))).))).))).)))))..)))))))))))..)))).........)))... (-65.30) ................................................................................CUGUGCGUGUGACAGCGGCUGA................................. 40 1 hsa-mir-210_R01_M ESC_WT_454 ................................................................................CUGUGCGUGUGACAGCGGCUG.................................. 4 1 hsa-mir-210_R02 ESC_WT_454 ................................................................................CUGUGCGUGUGACAGCGGCUGAU................................ 2 1 hsa-mir-210_R03 ESC_WT_454 ...............................................................................ACUGUGCGUGUGACAGCGGCUGA................................. 2 1 hsa-mir-210_R04 ESC_WT_454 hsa-mir-212 chr17:1900295-1900444 - CCGGGGCGACCGGGGCACCCCGCCCGGACAGCGCGCCGGCACCUUGGCUCUAGACUGCUUACUGCCCGGGCCGCCCUCAGUAACAGUCUCCAGUCACGGCCACCGACGCCUGGCCCCGCCCCAGGACCG ((((((((..((((....))))...((.(((.(((.(((..((.(((((..((((((.((((((...(((...))).))))))))))))..))))).))...))).)))))).)).)))))).)).... (-62.70) ................................................................................UAACAGUCUCCAGUCACGGCC............................ 2 1 hsa-mir-212_R01_M ESC_WT_454 hsa-mir-218-1 chr4:20138976-20139125 + GUUGGUGUAGUGAUAAUGUAGCGAGAUUUUCUGUUGUGCUUGAUCUAACCAUGUGGUUGCGAGGUAUGAGUAAAACAUGGUUCCGUCAAGCACCAUGGAACGUCACGCAGCUUUCUACAGCAUGACAAG ..((.(((((.......((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))...))))).))....... (-48.60) .................................UUGUGCUUGAUCUAACCAUGUG.......................................................................... 4 2 hsa-mir-218-1_L01_M ESC_WT_454 hsa-mir-218-2 chr5:168127709-168127858 - CCUUGACUCUGACCAGUCGCUGCGGGGCUUUCCUUUGUGCUUGAUCUAACCAUGUGGUGGAACGAUGGAAACGGAACAUGGUUCUGUCAAGCACCGCGGAAAGCACCGUGCUCUCCUGCAGCAUGGCCC ............(((...(((((((((((((((...(((((((((..((((((((..........((....))..))))))))..)))))))))...)))))))..........)))))))).)))... (-52.50) ..................................UUGUGCUUGAUCUAACCAUGUG......................................................................... 4 2 hsa-mir-218-2_L01_M ESC_WT_454 hsa-mir-219-1 chr6:33283570-33283719 + CUCCCUUCCCCGCCCCGGGCCGCGGCUCCUGAUUGUCCAAACGCAAUUCUCGAGUCUAUGGCUCCGGCCGAGAGUUGAGUCUGGACGUCCCGAGCCGCCGCCCCCAAACCUCGAGCGGGAGAGCGGGUC ..(((((((((((.(.((((.(((((((..(((.(((((.((.(((((((((.(((.........)))))))))))).)).))))))))..))))))).)))).........).))))).))).))).. (-64.60) .............................UGAUUGUCCAAACGCAAUUCUCG............................................................................. 2 1 hsa-mir-219-1_L01_M ESC_WT_454 .................................UGUCCAAACGCAAUUCUCG............................................................................. 1 1 hsa-mir-219-1_L02 ESC_WT_454 hsa-mir-22 chr17:1563927-1564051 - GCCCUCACCUGGCUGAGCCGCAGUAGUUCUUCAGUGGCAAGCUUUAUGUCCUGACCCAGCUAAAGCUGCCAGUUGAAGAACUGUUGCCCUCUGCCCCUGGCUUC (((.......(((.(((..((((((((((((((((((((.((((((.((.........))))))))))))).))))))))))))))).))).)))...)))... (-43.20) ........................AGUUCUUCAGUGGCAAGCUUUA.......................................................... 2 1 hsa-mir-22_L01*_M ESC_WT_454 .......................UAGUUCUUCAGUGGCAAGCUUUA.......................................................... 1 1 hsa-mir-22_L02* ESC_WT_454 ..............................................................AAGCUGCCAGUUGAAGAACUGU.................... 12 1 hsa-mir-22_R01_M ESC_WT_454 ..............................................................AAGCUGCCAGUUGAAGAACUG..................... 1 1 hsa-mir-22_R02 ESC_WT_454 hsa-mir-221 chrX:45490509-45490658 - ACUUGCAAGCUGAACAUCCAGGUCUGGGGCAUGAACCUGGCAUACAAUGUAGAUUUCUGUGUUCGUUAGGCAACAGCUACAUUGUCUGCUGGGUUUCAGGCUACCUGGAAACAUGUUCUCCAUUGGCUG .......((((((((((((((((....(((.((((((..(((.(((((((((....(((((((.....))).))))))))))))).)))..)).)))).))))))))))....)))))......)))). (-49.20) ..........................................................................AGCUACAUUGUCUGCUGGGUUUC................................ 17 1 hsa-mir-221_R01_M ESC_WT_454 ..........................................................................AGCUACAUUGUCUGCUGGGUUUCA............................... 4 1 hsa-mir-221_R02 ESC_WT_454 ..........................................................................AGCUACAUUGUCUGCUGGGUUU................................. 1 1 hsa-mir-221_R03 ESC_WT_454 hsa-mir-222 chrX:45491345-45491494 - GGAUCACCCAGCUGCUGGAAGGUGUAGGUACCCUCAAUGGCUCAGUAGCCAGUGUAGAUCCUGUCUUUCGUAAUCAGCAGCUACAUCUGGCUACUGGGUCUCUGAUGGCAUCUUCUAGCUUCUGCUUCA ........(((..(((((((((((......((.(((..(((((((((((((((((((...(((...........)))...))))).))))))))))))))..))).)))))))))))))..)))..... (-57.50) ..............................................................................AGCUACAUCUGGCUACUGGGUCUC........................... 4 1 hsa-mir-222_R01_M ESC_WT_454 ..............................................................................AGCUACAUCUGGCUACUGG................................ 1 1 hsa-mir-222_R02 ESC_WT_454 ..............................................................................AGCUACAUCUGGCUACUGGGU.............................. 1 1 hsa-mir-222_R03 ESC_WT_454 .............................................................................CAGCUACAUCUGGCUACUGGGUC............................. 1 1 hsa-mir-222_R04 ESC_WT_454 ............................................................................GCAGCUACAUCUGGCUACUGGGU.............................. 1 1 hsa-mir-222_R05 ESC_WT_454 hsa-mir-23a chr19:13808381-13808493 - CCUGUGCCACGGCCGGCUGGGGUUCCUGGGGAUGGGAUUUGCUUCCUGUCACAAAUCACAUUGCCAGGGAUUUCCAACCGACCCUGAGCUCUGCC ...(.((((.((.(((.((((((((((((.((((.((((((..........)))))).)))).))))))).))))).))).)).)).)).).... (-38.60) ..................GGGGUUCCUGGGGAUGGGAUUU....................................................... 11 1 hsa-mir-23a_L01*_M ESC_WT_454 ......................................................AUCACAUUGCCAGGGAUUUCCA................... 47 1 hsa-mir-23a_R01_M ESC_WT_454 ......................................................AUCACAUUGCCAGGGAUUUCCAA.................. 7 1 hsa-mir-23a_R02 ESC_WT_454 ......................................................AUCACAUUGCCAGGGAUUUCC.................... 5 1 hsa-mir-23a_R03 ESC_WT_454 ........................................................CACAUUGCCAGGGAUUUCCA................... 3 1 hsa-mir-23a_R04 ESC_WT_454 ......................................................AUCACAUUGCCAGGGAUUUC..................... 2 1 hsa-mir-23a_R05 ESC_WT_454 .......................................................UCACAUUGCCAGGGAUUUCCAA.................. 2 1 hsa-mir-23a_R06 ESC_WT_454 ......................................................AUCACAUUGCCAGGGAUUUCCA................... 1 1 hsa-mir-23a_R07 ESC_DGCR8_454 ......................................................AUCACAUUGCCAGGGAUUU...................... 1 1 hsa-mir-23a_R08 ESC_WT_454 hsa-mir-23b chr9:96887291-96887427 + GGUGGCGCUGCUCUCAGGUGCUCUGGCUGCUUGGGUUCCUGGCAUGCUGAUUUGUGACUUAAGAUUAAAAUCACAUUGCCAGGGAUUACCACGCAACCACGACCUUGGCUGCUCCUCCAGAA ((.((.((.(((...((((.(..(((.(((.(((((((((((((((.((((((..............)))))))).))))))))))..))).))).))).))))).))).)).)).)).... (-47.54) .....................................................................AUCACAUUGCCAGGGAUUACCAC.............................. 11 1 hsa-mir-23b_R01_M ESC_WT_454 .....................................................................AUCACAUUGCCAGGGAUUACCA............................... 5 1 hsa-mir-23b_R02 ESC_WT_454 .....................................................................AUCACAUUGCCAGGGAUUAC................................. 1 1 hsa-mir-23b_R03 ESC_WT_454 hsa-mir-24-1 chr9:96888104-96888211 + GGACCCGCCCUCCGGUGCCUACUGAGCUGAUAUCAGUUCUCAUUUUACACACUGGCUCAGUUCAGCAGGAACAGGAGUCGAGCCCUU ((.(.((..((((.((.(((.(((((((((..(((((.............))))).))))))))).))).)).)))).)).).)).. (-30.32) ....................................................UGGCUCAGUUCAGCAGGAACAG............. 68 2 hsa-mir-24-1_R01_M ESC_WT_454 ....................................................UGGCUCAGUUCAGCAGGAAC............... 4 2 hsa-mir-24-1_R02 ESC_WT_454 ....................................................UGGCUCAGUUCAGCAGGAACA.............. 3 2 hsa-mir-24-1_R03 ESC_WT_454 ....................................................UGGCUCAGUUCAGCAGGAACAG............. 1 2 hsa-mir-24-1_R04 ESC_DGCR8_454 ....................................................UGGCUCAGUUCAGCAGGA................. 1 2 hsa-mir-24-1_R05 ESC_WT_454 ........................................................UCAGUUCAGCAGGAACAG............. 1 2 hsa-mir-24-1_R06 ESC_WT_454 hsa-mir-24-2 chr19:13808081-13808193 - CCUCCCUGGGCUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGGGUCAAGCCCC .......(((((..(((.((.((.(((.(((((((((....((((.(.........)))))..))))))))).))).)).)))))..))))). (-38.90) ...........................................................UGGCUCAGUUCAGCAGGAACAG............ 68 2 hsa-mir-24-2_R01_M ESC_WT_454 ...........................................................UGGCUCAGUUCAGCAGGAAC.............. 4 2 hsa-mir-24-2_R02 ESC_WT_454 ...........................................................UGGCUCAGUUCAGCAGGAACA............. 3 2 hsa-mir-24-2_R03 ESC_WT_454 ...........................................................UGGCUCAGUUCAGCAGGAACAG............ 1 2 hsa-mir-24-2_R04 ESC_DGCR8_454 ...........................................................UGGCUCAGUUCAGCAGGA................ 1 2 hsa-mir-24-2_R05 ESC_WT_454 ...............................................................UCAGUUCAGCAGGAACAG............ 1 2 hsa-mir-24-2_R06 ESC_WT_454 hsa-mir-25 chr7:99529099-99529222 - CUCCGGGACUGGCCAGUGUUGAGAGGCGGAGACUUGGGCAAUUGCUGGACGCUGCCCUGGGCAUUGCACUUGUCUCGGUCUGACAGUGCCGGCCCAACACUGC ....(((.(((((.(.((((...((((.(((((..(.(((((.(((((.......))..)))))))).)..))))).)))))))).)))))))))........ (-42.00) .......................AGGCGGAGACUUGGGCAAUUGCU......................................................... 1 1 hsa-mir-25_L01*_M ESC_WT_454 .......................AGGCGGAGACUUGGGCAAUUG........................................................... 1 1 hsa-mir-25_L02* ESC_WT_454 .............................................................CAUUGCACUUGUCUCGGUCUGA.................... 79 1 hsa-mir-25_R01_M ESC_WT_454 .............................................................CAUUGCACUUGUCUCGGUCUG..................... 11 1 hsa-mir-25_R02 ESC_WT_454 .............................................................CAUUGCACUUGUCUCGGUCU...................... 9 1 hsa-mir-25_R03 ESC_WT_454 .............................................................CAUUGCACUUGUCUCGGUCUGA.................... 1 1 hsa-mir-25_R04 ESC_DGCR8_454 .............................................................CAUUGCACUUGUCUCGGUC....................... 1 1 hsa-mir-25_R05 ESC_WT_454 hsa-mir-26a-1 chr3:37985879-37985995 + GCGAAGGCCGUGGCCUCGUUCAAGUAAUCCAGGAUAGGCUGUGCAGGUCCCAAUGGGCCUAUUCUUGGUUACUUGCACGGGGACGCGGGCCUGGAC ....((((((((.((((((.(((((((((.((((((((((.((.......))...)))))))))).))))))))).)))))).))).))))).... (-48.50) ..................UUCAAGUAAUCCAGGAUAGGCU........................................................ 28 2 hsa-mir-26a-1_L01_M ESC_WT_454 ..................UUCAAGUAAUCCAGGAUAGGCU........................................................ 1 2 hsa-mir-26a-1_L02 ESC_DGCR8_454 ..................UUCAAGUAAUCCAGGAUAGGC......................................................... 1 2 hsa-mir-26a-1_L03 ESC_WT_454 ..................UUCAAGUAAUCCAGGAUAGG.......................................................... 1 2 hsa-mir-26a-1_L04 ESC_WT_454 hsa-mir-26a-2 chr12:56504639-56504762 - CUCCCAUAGAGGCUGUGGCUGGAUUCAAGUAAUCCAGGAUAGGCUGUUUCCAUCUGUGAGGCCUAUUCUUGAUUACUUGUUUCUGGAGGCAGCUGAUGGUCCG ...((((...((((((..(..((..(((((((((.((((((((((..............)))))))))).)))))))))..))..)..)))))).)))).... (-48.24) .......................UUCAAGUAAUCCAGGAUAGGCU.......................................................... 28 2 hsa-mir-26a-2_L01_M ESC_WT_454 .......................UUCAAGUAAUCCAGGAUAGGCU.......................................................... 1 2 hsa-mir-26a-2_L02 ESC_DGCR8_454 ......................AUUCAAGUAAUCCAGGAUAGGCU.......................................................... 1 1 hsa-mir-26a-2_L03 ESC_WT_454 .......................UUCAAGUAAUCCAGGAUAGGC........................................................... 1 2 hsa-mir-26a-2_L04 ESC_WT_454 .......................UUCAAGUAAUCCAGGAUAGG............................................................ 1 2 hsa-mir-26a-2_L05 ESC_WT_454 hsa-mir-26b chr2:218975593-218975709 + CCACCCUGCCCGGGACCCAGUUCAAGUAAUUCAGGAUAGGUUGUGUGCUGUCCAGCCUGUUCUCCAUUACUUGGCUCGGGGACCGGUGCCCUGCAG .......((((((..((((((.((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..)))).))....... (-43.80) ....................UUCAAGUAAUUCAGGAUAGGUU...................................................... 36 1 hsa-mir-26b_L01_M ESC_WT_454 ....................UUCAAGUAAUUCAGGAUAGGU....................................................... 3 1 hsa-mir-26b_L02 ESC_WT_454 ....................UUCAAGUAAUUCAGGAUAGG........................................................ 2 1 hsa-mir-26b_L03 ESC_WT_454 ....................UUCAAGUAAUUCAGGAUAGGUUG..................................................... 1 1 hsa-mir-26b_L04 ESC_WT_454 ......................CAAGUAAUUCAGGAUAGGUU...................................................... 1 1 hsa-mir-26b_L05 ESC_WT_454 hsa-mir-27a chr19:13808234-13808351 - CUGUGCCUGGCCUGAGGAGCAGGGCUUAGCUGCUUGUGAGCAGGGUCCACACCAAGUCGUGUUCACAGUGGCUAAGUUCCGCCCCCCAGGCCCUCACC ..(((...((((((.((.((.(((((((((..((.(((((((.((.(........))).)))))))))..))))))))).)).)).))))))..))). (-50.30) ....................AGGGCUUAGCUGCUUGUGAGC......................................................... 2 1 hsa-mir-27a_L01*_M ESC_WT_454 ....................AGGGCUUAGCUGCUUGUGAGCA........................................................ 1 1 hsa-mir-27a_L02* ESC_WT_454 .............................................................UUCACAGUGGCUAAGUUCCGC................ 179 1 hsa-mir-27a_R01_M ESC_WT_454 .............................................................UUCACAGUGGCUAAGUUCCG................. 16 1 hsa-mir-27a_R02 ESC_WT_454 .............................................................UUCACAGUGGCUAAGUUCC.................. 3 1 hsa-mir-27a_R03 ESC_WT_454 .............................................................UUCACAGUGGCUAAGUUC................... 3 2 hsa-mir-27a_R04 ESC_WT_454 .............................................................UUCACAGUGGCUAAGUUCCGC................ 1 1 hsa-mir-27a_R05 ESC_DGCR8_454 ...............................................................CACAGUGGCUAAGUUCCGC................ 1 1 hsa-mir-27a_R06 ESC_WT_454 ..............................................................UCACAGUGGCUAAGUUCCGC................ 1 1 hsa-mir-27a_R07 ESC_WT_454 hsa-mir-27b chr9:96887528-96887664 + CCAGCGAUGACCUCUCUAACAAGGUGCAGAGCUUAGCUGAUUGGUGAACAGUGAUUGGUUUCCGCUUUGUUCACAGUGGCUAAGUUCUGCACCUGAAGAGAAGGUGAGAUGGGGACAG (((....(.((((((((....((((((((((((((((((....((((((((....(((...)))..))))))))..))))))))))))))))))..)))).)))).)..)))...... (-55.10) ...........................AGAGCUUAGCUGAUUGGUGAAC..................................................................... 10 1 hsa-mir-27b_L01*_M ESC_WT_454 ...........................AGAGCUUAGCUGAUUGGUGAACA.................................................................... 10 1 hsa-mir-27b_L02* ESC_WT_454 .....................................................................UUCACAGUGGCUAAGUUCUGC............................ 155 1 hsa-mir-27b_R01_M ESC_WT_454 .....................................................................UUCACAGUGGCUAAGUUCUG............................. 19 1 hsa-mir-27b_R02 ESC_WT_454 .....................................................................UUCACAGUGGCUAAGUUCUGCA........................... 6 1 hsa-mir-27b_R03 ESC_WT_454 .....................................................................UUCACAGUGGCUAAGUUC............................... 3 2 hsa-mir-27b_R04 ESC_WT_454 .....................................................................UUCACAGUGGCUAAGUUCUGCAC.......................... 2 1 hsa-mir-27b_R05 ESC_WT_454 ......................................................................UCACAGUGGCUAAGUUCUGC............................ 1 1 hsa-mir-27b_R06 ESC_WT_454 ........................................................................ACAGUGGCUAAGUUCUGC............................ 1 1 hsa-mir-27b_R07 ESC_WT_454 hsa-mir-28 chr3:189889243-189889368 + AUUUAAAAUGGUCCUUGCCCUCAAGGAGCUCACAGUCUAUUGAGUUACCUUUCUGACUUUCCCACUAGAUUGUGAGCUCCUGGAGGGCAGGCACUUUCGUUCAUC .........(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).))).......... (-50.90) ......................AAGGAGCUCACAGUCUAUUGAG............................................................. 8 1 hsa-mir-28_L01_M ESC_WT_454 .....................CAAGGAGCUCACAGUCUAUUGAG............................................................. 3 1 hsa-mir-28_L02 ESC_WT_454 hsa-mir-296 chr20:56826045-56826164 - GUGAGGAGAAAGGACCCUUCCAGAGGGCCCCCCCUCAAUCCUGUUGUGCCUAAUUCAGAGGGUUGGGUGGAGGCUCUCCUGAAGGGCUCUGAAGAGCGCUGCA (((.......((..((((((..(((((((.((.(((((((((.(((.........)))))))))))).)).)))))))..))))))..))......))).... (-45.22) .......................AGGGCCCCCCCUCAAUCCUGU........................................................... 11 1 hsa-mir-296_L01_M ESC_WT_454 .......................AGGGCCCCCCCUCAAUCCUGUUG......................................................... 2 1 hsa-mir-296_L02 ESC_WT_454 .........................................................GAGGGUUGGGUGGAGGCUCUCC........................ 4 1 hsa-mir-296_R01*_M ESC_WT_454 .........................................................GAGGGUUGGGUGGAGGCUCU.......................... 3 1 hsa-mir-296_R02* ESC_WT_454 ...........................................................GGGUUGGGUGGAGGCUCUCC........................ 2 1 hsa-mir-296_R03* ESC_WT_454 ..........................................................AGGGUUGGGUGGAGGCUCUCC........................ 1 1 hsa-mir-296_R04* ESC_WT_454 ............................................................GGUUGGGUGGAGGCUCUCC........................ 1 1 hsa-mir-296_R05* ESC_WT_454 .........................................................GAGGGUUGGGUGGAGGCUCUC......................... 1 1 hsa-mir-296_R06* ESC_WT_454 hsa-mir-297 chr4:112001167-112001272 - UAUGAACAUAUGUAUGUAUGUGUGCAUGUGCAUGUAUGUGUAUAUACAUAUAUAUGUAUUAUGUACUCAUAUAUCAAGGAGAUUU ..........((.(((((((.((((((((((((((((((((....))))))))))))).))))))).)))))))))......... (-30.20) .............AUGUAUGUGUGCAUGUGCAUGU.................................................. 266 1 hsa-mir-297_L01_M ESC_WT_454 .............AUGUAUGUGUGCAUGUGCAUGUA................................................. 20 1 hsa-mir-297_L02 ESC_WT_454 .............AUGUAUGUGUGCAUGUGCAUG................................................... 17 1 hsa-mir-297_L03 ESC_WT_454 .............AUGUAUGUGUGCAUGUGCAU.................................................... 14 1 hsa-mir-297_L04 ESC_WT_454 .............AUGUAUGUGUGCAUGUGCAUGUAU................................................ 9 1 hsa-mir-297_L05 ESC_WT_454 ............UAUGUAUGUGUGCAUGUGCAUG................................................... 6 1 hsa-mir-297_L06 ESC_WT_454 ..............UGUAUGUGUGCAUGUGCAUGU.................................................. 5 1 hsa-mir-297_L07 ESC_WT_454 ............UAUGUAUGUGUGCAUGUGCAUGU.................................................. 4 1 hsa-mir-297_L08 ESC_WT_454 .............AUGUAUGUGUGCAUGUGCAUGU.................................................. 3 1 hsa-mir-297_L09 ESC_DGCR8_454 ............UAUGUAUGUGUGCAUGUGCAU.................................................... 3 1 hsa-mir-297_L10 ESC_WT_454 ..............UGUAUGUGUGCAUGUGCAUG................................................... 1 1 hsa-mir-297_L11 ESC_DGCR8_454 ................UAUGUGUGCAUGUGCAUG................................................... 1 1 hsa-mir-297_L12 ESC_WT_454 hsa-mir-299 chr14:100559864-100559966 + CGGUACUUGAAGAAAUGGUUUACCGUCCCACAUACAUUUUGAAUAUGUAUGUGGGAUGGUAAACCGCUUCUUGGUAUCCAGC .((((((..(((((.((((((((((((((((((((((.......)))))))))))))))))))))).))))))))))).... (-46.80) ...............UGGUUUACCGUCCCACAUACAU............................................. 12 1 hsa-mir-299_L01_M ESC_WT_454 ...............UGGUUUACCGUCCCACAUACA.............................................. 2 1 hsa-mir-299_L02 ESC_WT_454 hsa-mir-29a chr7:130212026-130212129 - CCCUUAGAGGAUGACUGAUUUCUUUUGGUGUUCAGAGUCAAUAUAAUUUUCUAGCACCAUCUGAAAUCGGUUAUAAUGAUUGG .((.......((((((((((((...(((((((.((((...........)))))))))))...)))))))))))).......)) (-27.24) ...................................................UAGCACCAUCUGAAAUCGGUUA.......... 13 1 hsa-mir-29a_R01_M ESC_WT_454 ...................................................UAGCACCAUCUGAAAUCGGUU........... 5 1 hsa-mir-29a_R02 ESC_WT_454 hsa-mir-29b-1 chr7:130212738-130212858 - CAUAAAGCUUCUUCAGGAAGCUGGUUUCAUAUGGUGGUUUAGAUUUAAAUAGUGAUUGUCUAGCACCAUUUGAAAUCAGUGUUCUUGGGGGAGACCAGCU .......((((((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))))))....... (-38.92) ...................GCUGGUUUCAUAUGGUGGUUUA........................................................... 1 1 hsa-mir-29b-1_L01*_M ESC_WT_454 ............................................................UAGCACCAUUUGAAAUCAGUGUU................. 18 2 hsa-mir-29b-1_R01_M ESC_WT_454 ............................................................UAGCACCAUUUGAAAUCAGUGU.................. 2 2 hsa-mir-29b-1_R02 ESC_WT_454 .................................................................CCAUUUGAAAUCAGUGUU................. 1 2 hsa-mir-29b-1_R03 ESC_WT_454 hsa-mir-29b-2 chr1:206042391-206042511 - AGAUCCUCUUCUUCUGGAAGCUGGUUUCACAUGGUGGCUUAGAUUUUUCCAUCUUUGUAUCUAGCACCAUUUGAAAUCAGUGUUUUAGGAGUAAGAAUUG ......(((((((((((((((((((((((.((((((.((.((((..............)))))))))))).)))))))))).))))))))).)))).... (-35.64) .............................................................UAGCACCAUUUGAAAUCAGUGUU................ 18 2 hsa-mir-29b-2_R01_M ESC_WT_454 .............................................................UAGCACCAUUUGAAAUCAGUGU................. 2 2 hsa-mir-29b-2_R02 ESC_WT_454 ..................................................................CCAUUUGAAAUCAGUGUU................ 1 2 hsa-mir-29b-2_R03 ESC_WT_454 hsa-mir-29c chr1:206041800-206041927 - CCACUGGCCCAUCUCUUACACAGGCUGACCGAUUUCUCCUGGUGUUCAGAGUCUGUUUUUGUCUAGCACCAUUUGAAAUCGGUUAUGAUGUAGGGGGAAAAGCAGCA ...(((.....(((((((((((...(((((((((((...((((((((((((.....)))))...)))))))...))))))))))))).))))))))).....))).. (-36.70) ...............................................................UAGCACCAUUUGAAAUCGGUUA...................... 2 1 hsa-mir-29c_R01_M ESC_WT_454 ...............................................................UAGCACCAUUUGAAAUCGGUU....................... 1 1 hsa-mir-29c_R02 ESC_WT_454 hsa-mir-301a chr17:54583259-54583384 - CCUACUUAUUACUGCUAACGAAUGCUCUGACUUUAUUGCACUACUGUACUUUACAGCUAGCAGUGCAAUAGUAUUGUCAAAGCAUCUGAAAGCAGGAUGCACGCC ...........(((((..((.(((((.((((.((((((((((.(((((...))))).....))))))))))....)))).))))).))..))))).......... (-32.80) ............................................................CAGUGCAAUAGUAUUGUCAAAGCAU.................... 27 1 hsa-mir-301a_R01_M ESC_WT_454 ............................................................CAGUGCAAUAGUAUUGUCAAAGC...................... 20 1 hsa-mir-301a_R02 ESC_WT_454 ............................................................CAGUGCAAUAGUAUUGUCAAAG....................... 19 1 hsa-mir-301a_R03 ESC_WT_454 ............................................................CAGUGCAAUAGUAUUGUCAAAGCA..................... 3 1 hsa-mir-301a_R04 ESC_WT_454 ............................................................CAGUGCAAUAGUAUUGUCAAA........................ 2 1 hsa-mir-301a_R05 ESC_WT_454 hsa-mir-301b chr22:20337250-20337367 + CCCCUGCUGGCCGCAGGUGCUCUGACGAGGUUGCACUACUGUGCUCUGAGAAGCAGUGCAAUGAUAUUGUCAAAGCAUCUGGGACCAGCCUUGGGGA ((((.(((((((.((((((((.((((((.((((((((.((...(.....).)).))))))))....)))))).)))))))))).)))))...)))). (-51.20) .....................................................CAGUGCAAUGAUAUUGUCAAAGC..................... 1 1 hsa-mir-301b_R01_M ESC_WT_454 hsa-mir-302a chr4:113788768-113788876 - CCAAGACUGGGCUCCCCACCACUUAAACGUGGAUGUACUUGCUUUGAAACUAAAGAAGUAAGUGCUUCCAUGUUUUGGUGAUGGUAAGUCUUCC ........(((((..(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))..)))))... (-41.00) ..........................................................UAAGUGCUUCCAUGUUUUGGUGA............. 391 1 hsa-mir-302a_R01_M ESC_WT_454 ..........................................................UAAGUGCUUCCAUGUUUUGGU............... 41 1 hsa-mir-302a_R02 ESC_WT_454 ...........................................................AAGUGCUUCCAUGUUUUGGUGA............. 10 1 hsa-mir-302a_R03 ESC_WT_454 ..........................................................UAAGUGCUUCCAUGUUUUGGUGAU............ 5 1 hsa-mir-302a_R04 ESC_WT_454 ..........................................................UAAGUGCUUCCAUGUUUUGGUG.............. 2 1 hsa-mir-302a_R05 ESC_WT_454 ............................................................AGUGCUUCCAUGUUUUGGUGA............. 1 1 hsa-mir-302a_R06 ESC_WT_454 hsa-mir-302b chr4:113789070-113789182 - AAGUUGUAUGUUGGGUGGGCUCCCUUCAACUUUAACAUGGAAGUGCUUUCUGUGACUUUAAAAGUAAGUGCUUCCAUGUUUUAGUAGGAGUGAAUCCAAU .........(((((((..(((((.....(((..((((((((((..(((.((...........)).)))..))))))))))..))).)))))..))))))) (-38.80) ................................................................UAAGUGCUUCCAUGUUUUAGUAG............. 119 1 hsa-mir-302b_R01_M ESC_WT_454 ................................................................UAAGUGCUUCCAUGUUUUAGU............... 25 1 hsa-mir-302b_R02 ESC_WT_454 ................................................................UAAGUGCUUCCAUGUUUUAGUA.............. 18 1 hsa-mir-302b_R03 ESC_WT_454 .................................................................AAGUGCUUCCAUGUUUUAGUAG............. 3 1 hsa-mir-302b_R04 ESC_WT_454 ................................................................UAAGUGCUUCCAUGUUUUAGUAG............. 1 1 hsa-mir-302b_R05 ESC_DGCR8_454 hsa-mir-302c chr4:113788948-113789055 - UUGAAGGGAUCCCCUUUGCUUUAACAUGGGGGUACCUGCUGUGUGAAACAAAAGUAAGUGCUUCCAUGUUUCAGUGGAGGUGUCUCCAA ......(((..(((((..((..(((((((((((((.((((.((.....))..)))).)))))))))))))..))..)))).)..))).. (-38.30) .......................................................AAGUGCUUCCAUGUUUCAGUGG............ 1 1 hsa-mir-302c_R01_M ESC_WT_454 hsa-mir-302d chr4:113788589-113788696 - UAAGGGGCCCCCUCUACUUUAACAUGGAGGCACUUGCUGUGACAUGACAAAAAUAAGUGCUUCCAUGUUUGAGUGUGGUGGUUCCUAC ..(((((((.((.(.((((.((((((((((((((((.(((......)))....)))))))))))))))).))))).)).))))))).. (-42.40) ..............UACUUUAACAUGGAGGCACUUG.................................................... 4 1 hsa-mir-302d_L01*_M ESC_WT_454 ..............UACUUUAACAUGGAGGCACUUGC................................................... 2 1 hsa-mir-302d_L02* ESC_WT_454 ...............ACUUUAACAUGGAGGCACUUGCU.................................................. 1 1 hsa-mir-302d_L03* ESC_WT_454 .....................................................UAAGUGCUUCCAUGUUUGAGUGU............ 721 1 hsa-mir-302d_R01_M ESC_WT_454 .....................................................UAAGUGCUUCCAUGUUUGAGUG............. 91 1 hsa-mir-302d_R02 ESC_WT_454 .......................................................AGUGCUUCCAUGUUUGAGUGU............ 39 1 hsa-mir-302d_R03 ESC_WT_454 ......................................................AAGUGCUUCCAUGUUUGAGUGU............ 9 1 hsa-mir-302d_R04 ESC_WT_454 .....................................................UAAGUGCUUCCAUGUUUGAGUGU............ 8 1 hsa-mir-302d_R05 ESC_DGCR8_454 .....................................................UAAGUGCUUCCAUGUUUGAGU.............. 7 1 hsa-mir-302d_R06 ESC_WT_454 .....................................................UAAGUGCUUCCAUGUUUGAGUG............. 1 1 hsa-mir-302d_R07 ESC_DGCR8_454 .................................................AAAAUAAGUGCUUCCAUGUUUGAGUGU............ 1 1 hsa-mir-302d_R08 ESC_WT_454 hsa-mir-30a chr6:72169955-72170065 - UUGACAGUGAGCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGCCUACUGCCU ....(((((.(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).))).)))))... (-44.50) ...............UGUAAACAUCCUCGACUGGAAGC.................................................... 13 1 hsa-mir-30a_L01_M ESC_WT_454 ...............UGUAAACAUCCUCGACUGGAAGCU................................................... 8 1 hsa-mir-30a_L02 ESC_WT_454 ...............UGUAAACAUCCUCGACUGGAAG..................................................... 4 1 hsa-mir-30a_L03 ESC_WT_454 hsa-mir-30b chr8:135881925-135882052 - AGUCCUGCUUUAAACCAAGUUUCAGUUCAUGUAAACAUCCUACACUCAGCUGUAAUACAUGGAUUGGCUGGGAGGUGGAUGUUUACUUCAGCUGACUUGGAAUGUCAACCAAU ..............(((((..((((((...((((((((((.((.((((((((............))))))))..))))))))))))...)))))))))))............. (-37.60) .............................UGUAAACAUCCUACACUCAGCU.............................................................. 71 1 hsa-mir-30b_L01_M ESC_WT_454 .............................UGUAAACAUCCUACACUCAGC............................................................... 10 1 hsa-mir-30b_L02 ESC_WT_454 .............................UGUAAACAUCCUACACUCAG................................................................ 5 1 hsa-mir-30b_L03 ESC_WT_454 .............................UGUAAACAUCCUACACUCA................................................................. 1 1 hsa-mir-30b_L04 ESC_WT_454 hsa-mir-30c-1 chr1:40995523-40995651 + UGGGCUAUAACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGAAAACAUCAGC ((((((...((...((((.((.(((((.........))))).)))))).)).))))))..(((((.(((((.((((.....))))))))))))))............. (-35.70) .........................UGUAAACAUCCUACACUCUCAGCU........................................................... 247 2 hsa-mir-30c-1_L01_M ESC_WT_454 .........................UGUAAACAUCCUACACUCUCAGC............................................................ 73 2 hsa-mir-30c-1_L02 ESC_WT_454 .........................UGUAAACAUCCUACACUCUCAG............................................................. 13 2 hsa-mir-30c-1_L03 ESC_WT_454 .........................UGUAAACAUCCUACACUCUCAGCU........................................................... 3 2 hsa-mir-30c-1_L04 ESC_DGCR8_454 .........................UGUAAACAUCCUACACUCUC............................................................... 1 2 hsa-mir-30c-1_L05 ESC_WT_454 ..........................GUAAACAUCCUACACUCUCAGC............................................................ 1 2 hsa-mir-30c-1_L06 ESC_WT_454 hsa-mir-30c-2 chr6:72143364-72143475 - ACUGAGCGACAGAUACUGUAAACAUCCUACACUCUCAGCUGUGGAAAGUAAGAAAGCUGGGAGAAGGCUGUUUACUCUUUCUGCCUUGGAA .(..((.(.((((....(((((((.(((...(((((((((..............))))))))).))).)))))))....)))))))..).. (-34.14) ................UGUAAACAUCCUACACUCUCAGCU................................................... 247 2 hsa-mir-30c-2_L01_M ESC_WT_454 ................UGUAAACAUCCUACACUCUCAGC.................................................... 73 2 hsa-mir-30c-2_L02 ESC_WT_454 ................UGUAAACAUCCUACACUCUCAG..................................................... 13 2 hsa-mir-30c-2_L03 ESC_WT_454 ................UGUAAACAUCCUACACUCUCAGCU................................................... 3 2 hsa-mir-30c-2_L04 ESC_DGCR8_454 ...............CUGUAAACAUCCUACACUCUCAGCU................................................... 2 1 hsa-mir-30c-2_L05 ESC_WT_454 ................UGUAAACAUCCUACACUCUC....................................................... 1 2 hsa-mir-30c-2_L06 ESC_WT_454 .................GUAAACAUCCUACACUCUCAGC.................................................... 1 2 hsa-mir-30c-2_L07 ESC_WT_454 ...............CUGUAAACAUCCUACACUCUCAG..................................................... 1 1 hsa-mir-30c-2_L08 ESC_WT_454 hsa-mir-30d chr8:135886281-135886390 - UUGUUCAGAAAGUCUGUUGUUGUAAACAUCCCCGACUGGAAGCUGUAAGACACAGCUAAGCUUUCAGUCAGAUGUUUGCUGCUACCGGCUAUUC .......(((((((.((.((.(((((((((...(((((((((((...((......)).))))))))))).))))))))).)).)).)))).))) (-34.30) ....................UGUAAACAUCCCCGACUGGAAGC................................................... 12 1 hsa-mir-30d_L01_M ESC_WT_454 ....................UGUAAACAUCCCCGACUGGAAG.................................................... 10 1 hsa-mir-30d_L02 ESC_WT_454 ....................UGUAAACAUCCCCGACUGGAAGCU.................................................. 8 1 hsa-mir-30d_L03 ESC_WT_454 ....................UGUAAACAUCCCCGACUGGAA..................................................... 3 1 hsa-mir-30d_L04 ESC_WT_454 ....................UGUAAACAUCCCCGACUGGA...................................................... 2 1 hsa-mir-30d_L05 ESC_WT_454 ..........................CAUCCCCGACUGGAAGCU.................................................. 1 1 hsa-mir-30d_L06 ESC_WT_454 ....................UGUAAACAUCCCCGACUGG....................................................... 1 1 hsa-mir-30d_L07 ESC_WT_454 ............................................................CUUUCAGUCAGAUGUUUGCUGC............ 1 1 hsa-mir-30d_R01*_M ESC_WT_454 hsa-mir-30e chr1:40992594-40992725 + CGUUCUUUCUGGGCAGUCUUUGCUACUGUAAACAUCCUUGACUGGAAGCUGUAAGGUGUUCAGAGGAGCUUUCAGUCGGAUGUUUACAGCGGCAGGCUGCCACGGUCGUCCCCA ........(((((((((((..((..((((((((((((..(((((((((((.(...(....)...).)))))))))))))))))))))))..)))))))))).)))......... (-55.00) ..........................UGUAAACAUCCUUGACUGGAAGCU................................................................ 15 1 hsa-mir-30e_L01_M ESC_WT_454 ..........................UGUAAACAUCCUUGACUGGAAG.................................................................. 7 1 hsa-mir-30e_L02 ESC_WT_454 ..........................UGUAAACAUCCUUGACUGGAAGC................................................................. 4 1 hsa-mir-30e_L03 ESC_WT_454 ..........................UGUAAACAUCCUUGACUGGA.................................................................... 2 1 hsa-mir-30e_L04 ESC_WT_454 ..........................UGUAAACAUCCUUGACUGGAA................................................................... 1 1 hsa-mir-30e_L05 ESC_WT_454 ...........................GUAAACAUCCUUGACUGGAAGC................................................................. 1 1 hsa-mir-30e_L06 ESC_WT_454 ....................................................................CUUUCAGUCGGAUGUUUACAGC........................ 1 1 hsa-mir-30e_R01*_M ESC_WT_454 hsa-mir-31 chr9:21502094-21502204 - AACUUGGAACUGGAGAGGAGGCAAGAUGCUGGCAUAGCUGUUGAACUGGGAACCUGCUAUGCCAACAUAUUGCCAUCUUUCCUGUCUGACA ...(..((...((((((..(((((.(((.(((((((((.(((........)))..))))))))).))).)))))..))))))..))..).. (-40.80) ..................AGGCAAGAUGCUGGCAUAGCUG................................................... 49 1 hsa-mir-31_L01_M ESC_WT_454 ..................AGGCAAGAUGCUGGCAUAGCUGU.................................................. 14 1 hsa-mir-31_L02 ESC_WT_454 ..................AGGCAAGAUGCUGGCAUAGCU.................................................... 2 1 hsa-mir-31_L03 ESC_WT_454 ..................AGGCAAGAUGCUGGCAUAGC..................................................... 1 1 hsa-mir-31_L04 ESC_WT_454 ...................GGCAAGAUGCUGGCAUAGCUG................................................... 1 1 hsa-mir-31_L05 ESC_WT_454 ......................................................UGCUAUGCCAACAUAUUGCCAUC.............. 3 1 hsa-mir-31_R01*_M ESC_WT_454 ......................................................UGCUAUGCCAACAUAUUGCCAUCU............. 1 1 hsa-mir-31_R02* ESC_WT_454 .......................................................GCUAUGCCAACAUAUUGCCAUC.............. 1 1 hsa-mir-31_R03* ESC_WT_454 hsa-mir-32 chr9:110848310-110848419 - UUGCUCUGGUGGAGAUAUUGCACAUUACUAAGUUGCAUGUUGUCACGGCCUCAAUGCAAUUUAGUGUGUGUGAUAUUUUCACAUGAGUG ..((((..((((((((((..(((((.(((((((((((((..((....))..).)))))))))))))))))..))))))))))..)))). (-42.30) ...............UAUUGCACAUUACUAAGUUGCA.................................................... 43 1 hsa-mir-32_L01_M ESC_WT_454 ...............UAUUGCACAUUACUAAGUUGC..................................................... 20 1 hsa-mir-32_L02 ESC_WT_454 ...............UAUUGCACAUUACUAAGUUG...................................................... 3 1 hsa-mir-32_L03 ESC_WT_454 ...............UAUUGCACAUUACUAAGUUGCAU................................................... 2 1 hsa-mir-32_L04 ESC_WT_454 ..............AUAUUGCACAUUACUAAGUUGCA.................................................... 1 1 hsa-mir-32_L05 ESC_WT_454 .................UUGCACAUUACUAAGUUGC..................................................... 1 1 hsa-mir-32_L06 ESC_WT_454 hsa-mir-320a chr8:22158400-22158521 - AUCAGGCGGCGCUUCGCUCCCCUCCGCCUUCUCUUCCCGGUUCUUCCCGGAGUCGGGAAAAGCUGGGUUGAGAGGGCGAAAAAGGAUGAGGUGACUGGUCU (((((....(((((((.(((....(((((((((..(((((((.((((((....)))))).)))))))..))))))))).....)))))))))).))))).. (-53.90) .........................GCCUUCUCUUCCCGGUUCUUCC...................................................... 1 1 hsa-mir-320a_L01*_M ESC_WT_454 .........................................................AAAAGCUGGGUUGAGAGGGCGA...................... 55 1 hsa-mir-320a_R01_M ESC_DGCR8_454 .........................................................AAAAGCUGGGUUGAGAGGGCGAA..................... 14 1 hsa-mir-320a_R02 ESC_DGCR8_454 .........................................................AAAAGCUGGGUUGAGAGGGCGA...................... 11 1 hsa-mir-320a_R03 ESC_WT_454 .........................................................AAAAGCUGGGUUGAGAGGGCG....................... 9 1 hsa-mir-320a_R04 ESC_DGCR8_454 ..........................................................AAAGCUGGGUUGAGAGGGCGA...................... 7 1 hsa-mir-320a_R05 ESC_DGCR8_454 ........................................................GAAAAGCUGGGUUGAGAGGGCGA...................... 4 1 hsa-mir-320a_R06 ESC_DGCR8_454 ............................................................AGCUGGGUUGAGAGGGCGA...................... 3 1 hsa-mir-320a_R07 ESC_DGCR8_454 .............................................................GCUGGGUUGAGAGGGCGA...................... 3 1 hsa-mir-320a_R08 ESC_DGCR8_454 ..........................................................AAAGCUGGGUUGAGAGGGCGAA..................... 3 1 hsa-mir-320a_R09 ESC_DGCR8_454 .........................................................AAAAGCUGGGUUGAGAGGGCGAAA.................... 3 1 hsa-mir-320a_R10 ESC_DGCR8_454 ........................................................GAAAAGCUGGGUUGAGAGGG......................... 3 5 hsa-mir-320a_R11 ESC_DGCR8_454 ...........................................................AAGCUGGGUUGAGAGGGCGA...................... 2 1 hsa-mir-320a_R12 ESC_DGCR8_454 ..........................................................AAAGCUGGGUUGAGAGGGCGAAA.................... 2 1 hsa-mir-320a_R13 ESC_DGCR8_454 .............................................................GCUGGGUUGAGAGGGCGAA..................... 2 1 hsa-mir-320a_R14 ESC_DGCR8_454 ............................................................AGCUGGGUUGAGAGGGCGA...................... 2 1 hsa-mir-320a_R15 ESC_WT_454 ............................................................AGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R16 ESC_DGCR8_454 ..............................................................CUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R17 ESC_DGCR8_454 ...........................................................AAGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R18 ESC_DGCR8_454 ..........................................................AAAGCUGGGUUGAGAGGGCG....................... 1 1 hsa-mir-320a_R19 ESC_DGCR8_454 .........................................................AAAAGCUGGGUUGAGAGGG......................... 1 5 hsa-mir-320a_R20 ESC_DGCR8_454 ..............................................................CUGGGUUGAGAGGGCGAAA.................... 1 1 hsa-mir-320a_R21 ESC_DGCR8_454 .........................................................AAAAGCUGGGUUGAGAGGGC........................ 1 3 hsa-mir-320a_R22 ESC_WT_454 .............................................................GCUGGGUUGAGAGGGCGA...................... 1 1 hsa-mir-320a_R23 ESC_WT_454 .........................................................AAAAGCUGGGUUGAGAGGGCGAAA.................... 1 1 hsa-mir-320a_R24 ESC_WT_454 ..........................................................AAAGCUGGGUUGAGAGGG......................... 1 5 hsa-mir-320a_R25 ESC_WT_454 ...........................................................AAGCUGGGUUGAGAGGGC........................ 1 3 hsa-mir-320a_R26 ESC_WT_454 .........................................................AAAAGCUGGGUUGAGAGGGCGAA..................... 1 1 hsa-mir-320a_R27 ESC_WT_454 ........................................................GAAAAGCUGGGUUGAGAGGGCG....................... 1 1 hsa-mir-320a_R28 ESC_WT_454 ........................................................GAAAAGCUGGGUUGAGAGGGCGA...................... 1 1 hsa-mir-320a_R29 ESC_WT_454 ..........................................................AAAGCUGGGUUGAGAGGGCG....................... 1 1 hsa-mir-320a_R30 ESC_WT_454 ....................................................UCGGGAAAAGCUGGGUUG............................... 1 1 hsa-mir-320a_R31 ESC_WT_454 hsa-mir-320b-1 chr1:117015874-117015992 + UCAAAAAUAAAUUAAUCCCUCUCUUUCUAGUUCUUCCUAGAGUGAGGAAAAGCUGGGUUGAGAGGGCAAACAAAUUAACUAAUUAAUUAACUAAUUAA ................(((((((..(((((((.(((((......))))).)))))))..))))))).............((((((......)))))). (-29.00) ...................................................GCUGGGUUGAGAGGGCAA............................. 1 2 hsa-mir-320b-1_R01_M ESC_DGCR8_454 ..............................................GAAAAGCUGGGUUGAGAGGG................................ 3 5 hsa-mir-320b-1_O01 ESC_DGCR8_454 ...............................................AAAAGCUGGGUUGAGAGGG................................ 1 5 hsa-mir-320b-1_O02 ESC_DGCR8_454 ...............................................AAAAGCUGGGUUGAGAGGGC............................... 1 3 hsa-mir-320b-1_O03 ESC_WT_454 .................................................AAGCUGGGUUGAGAGGGC............................... 1 3 hsa-mir-320b-1_O04 ESC_WT_454 ................................................AAAGCUGGGUUGAGAGGG................................ 1 5 hsa-mir-320b-1_O05 ESC_WT_454 hsa-mir-320b-2 chr1:222511309-222511486 - AUAUCAGAAUUGUUAUUUUUUGUCUUCUACCUAAGAAUUCUGUCUCUUAGGCUUUCUCUUCCCAGAUUUCCCAAAGUUGGGAAAAGCUGGGUUGAGAGGGCAAAAGGAAAAAAAAAGAAUUCUGUCUCUGACAUAAUUAGAUAGGGAACCAGUUGGG ....(((((((.((.((((((.((((....((((((........))))))((((((((..(((((.(((((((....)))))))..)))))..))))))))..)))))))))).)).)))))))((((((.(.......).)))))).((....)). (-50.30) ................................................................................GAAAAGCUGGGUUGAGAGGG......................................................... 3 5 hsa-mir-320b-2_R01_M ESC_DGCR8_454 .................................................................................AAAAGCUGGGUUGAGAGGG......................................................... 1 5 hsa-mir-320b-2_R02 ESC_DGCR8_454 .....................................................................................GCUGGGUUGAGAGGGCAA...................................................... 1 2 hsa-mir-320b-2_R03 ESC_DGCR8_454 .................................................................................AAAAGCUGGGUUGAGAGGGC........................................................ 1 3 hsa-mir-320b-2_R04 ESC_WT_454 ...................................................................................AAGCUGGGUUGAGAGGGC........................................................ 1 3 hsa-mir-320b-2_R05 ESC_WT_454 ..................................................................................AAAGCUGGGUUGAGAGGG......................................................... 1 5 hsa-mir-320b-2_R06 ESC_WT_454 hsa-mir-320c-1 chr18:17517449-17517576 + AAAAUGUGUUUUGCAUUAAAAAUGAGGCCUUCUCUUCCCAGUUCUUCCCAGAGUCAGGAAAAGCUGGGUUGAGAGGGUAGAAAAAAAAUGAUGUAGGUGAAUAACUA ....(((..(((((((((........((((((((..(((((((.((((........)))).)))))))..))))))))..........)))))))))...))).... (-35.77) .........................................................GAAAAGCUGGGUUGAGAGGG.............................. 3 5 hsa-mir-320c-1_R01_M ESC_DGCR8_454 ..........................................................AAAAGCUGGGUUGAGAGGG.............................. 1 5 hsa-mir-320c-1_R02 ESC_DGCR8_454 ...........................................................AAAGCUGGGUUGAGAGGG.............................. 1 5 hsa-mir-320c-1_R03 ESC_WT_454 hsa-mir-320c-2 chr18:20155628-20155717 + AUAAAAUGGCAUGACAGGCCUUCUCUUUCCAGUUCUUCCCAGAAUUGGGAAAAGCUGGGUUGAGAGGGUAAGAAAAGAAAAACAAAUAA .................((((((((..(((((((.(((((......))))).)))))))..)))))))).................... (-32.60) ................................................GAAAAGCUGGGUUGAGAGGG..................... 3 5 hsa-mir-320c-2_R01_M ESC_DGCR8_454 .................................................AAAAGCUGGGUUGAGAGGG..................... 1 5 hsa-mir-320c-2_R02 ESC_DGCR8_454 ..................................................AAAGCUGGGUUGAGAGGG..................... 1 5 hsa-mir-320c-2_R03 ESC_WT_454 hsa-mir-323 chr14:100561802-100561927 + GGCUGCUGCUUGGUACUUGGAGAGAGGUGGUCCGUGGCGCGUUCGCUUUAUUUAUGGCGCACAUUACACGGUCGACCUCUUUGCAGUAUCUAAUCCCGCCUUGCA (((........((((((.(.((((((((.(.(((((....((.((((........)))).))....))))).).)))))))).))))))).......)))..... (-41.66) ...........................................................CACAUUACACGGUCGACCUCU......................... 38 1 hsa-mir-323_R01_M ESC_WT_454 ..........................................................GCACAUUACACGGUCGACCUCU......................... 6 1 hsa-mir-323_R02 ESC_WT_454 ...........................................................CACAUUACACGGUCGACCUCU......................... 2 1 hsa-mir-323_R03 ESC_DGCR8_454 .............................................................CAUUACACGGUCGACCUCU......................... 1 1 hsa-mir-323_R04 ESC_WT_454 ...........................................................CACAUUACACGGUCGACCUC.......................... 1 1 hsa-mir-323_R05 ESC_WT_454 hsa-mir-324 chr17:7067320-7067442 - AGAAGCUGAGCUGACUAUGCCUCCCCGCAUCCCCUAGGGCAUUGGUGUAAAGCUGGAGACCCACUGCCCCAGGUGCUGCUGGGGGUUGUAGUCUGACCCGAC ............((((((..(((((.(((.(.(((.(((((.(((.((..........))))).))))).))).).))).)))))..))))))......... (-39.80) .........................CGCAUCCCCUAGGGCAUUGGUGU...................................................... 26 1 hsa-mir-324_L01_M ESC_WT_454 .........................CGCAUCCCCUAGGGCAUUGGU........................................................ 8 1 hsa-mir-324_L02 ESC_WT_454 .........................CGCAUCCCCUAGGGCAUUGGUGUA..................................................... 4 1 hsa-mir-324_L03 ESC_WT_454 .........................CGCAUCCCCUAGGGCAUUGGUGUAAA................................................... 3 1 hsa-mir-324_L04 ESC_WT_454 .........................CGCAUCCCCUAGGGCAUUGGUGUAA.................................................... 1 1 hsa-mir-324_L05 ESC_WT_454 ............................................................CCACUGCCCCAGGUGCUGCUGG.................... 5 1 hsa-mir-324_R01*_M ESC_WT_454 .............................................................CACUGCCCCAGGUGCUGCUGG.................... 1 1 hsa-mir-324_R02* ESC_DGCR8_454 ..............................................................ACUGCCCCAGGUGCUGCUG..................... 1 1 hsa-mir-324_R03* ESC_WT_454 ..............................................................ACUGCCCCAGGUGCUGCUGG.................... 1 1 hsa-mir-324_R04* ESC_WT_454 hsa-mir-330 chr19:50834072-50834205 - GCUGUGUGAUCUUUGGCGAUCACUGCCUCUCUGGGCCUGUGUCUUAGGCUCUGCAAGAUCAACCGAGCAAAGCACACGGCCUGCAGAGAGGCAGCGCUCUGCCCCUUACUCGGCC ((((.((((.....(((((.(.(((((((((((((((((((.(((..((((.............)))).))))))).))))..))))))))))).).)).)))..)))).)))). (-53.82) ...........................UCUCUGGGCCUGUGUCUUAGGC.................................................................. 3 1 hsa-mir-330_L01_M ESC_WT_454 ...........................UCUCUGGGCCUGUGUCUUAGGCU................................................................. 1 1 hsa-mir-330_L02 ESC_WT_454 hsa-mir-331 chr12:94226307-94226440 + ACUCCCAAGGAGUUUGGUUUUGUUUGGGUUUGUUCUAGGUAUGGUCCCAGGGAUCCCAGAUCAAACCAGGCCCCUGGGCCUAUCCUAGAACCAACCUAAGCUCGCGCAUCAUU (((((...))))).((((...(((((((((.((((((((.((((.(((((((..(.............)..))))))).)))))))))))).)))))))))..)).))..... (-48.22) ..................................CUAGGUAUGGUCCCAGGGAUCC......................................................... 3 1 hsa-mir-331_L01_M ESC_WT_454 ..................................CUAGGUAUGGUCCCAGGGAUC.......................................................... 2 1 hsa-mir-331_L02 ESC_WT_454 .................................UCUAGGUAUGGUCCCAGGGAUC.......................................................... 1 1 hsa-mir-331_L03 ESC_WT_454 .....................................................................GCCCCUGGGCCUAUCCUAGAA....................... 3 1 hsa-mir-331_R01*_M ESC_WT_454 hsa-mir-335 chr7:129923168-129923301 + GGAAAUGAUUUGUUUUGAGCGGGGGUCAAGAGCAAUAACGAAAAAUGUUUGUCAUAAACCGUUUUUCAUUAUUGCUCCUGACCUCCUCUCAUUUGCUAUAUUCAAUUAAGUAAGU .....(((...((..((((.((((((((.(((((((((.((((((((.((......)).)))))))).))))))))).)))))))).))))...)).....)))........... (-42.80) .........................UCAAGAGCAAUAACGAAAAAUGU................................................................... 16 1 hsa-mir-335_L01_M ESC_WT_454 .........................UCAAGAGCAAUAACGAAAAAUG.................................................................... 14 1 hsa-mir-335_L02 ESC_WT_454 .........................UCAAGAGCAAUAACGAAAAAU..................................................................... 3 1 hsa-mir-335_L03 ESC_WT_454 .........................UCAAGAGCAAUAACGAAAAAUG.................................................................... 1 1 hsa-mir-335_L04 ESC_DGCR8_454 ............................AGAGCAAUAACGAAAAAUGUUU................................................................. 1 1 hsa-mir-335_L05 ESC_WT_454 .............................................................UUUUUCAUUAUUGCUCCUGACC................................ 3 1 hsa-mir-335_R01*_M ESC_WT_454 .............................................................UUUUUCAUUAUUGCUCCUGAC................................. 1 1 hsa-mir-335_R02* ESC_WT_454 ..............................................................UUUUCAUUAUUGCUCCUGACC................................ 1 1 hsa-mir-335_R03* ESC_WT_454 hsa-mir-337 chr14:100410563-100410695 + UUGCGGCCCGUAGUCAGUAGUUGGGGGGUGGGAACGGCUUCAUACAGGAGUUGAUGCACAGUUAUCCAGCUCCUAUAUGAUGCCUUUCUUCAUCCCCUUCAACCACGCGCAG .((((....(....).((.(((((((((((((((.(((.(((((.(((((((((((......))).)))))))).))))).))).))).))))))))..)))).)).)))). (-46.50) ...................................................................AGCUCCUAUAUGAUGCCUUUCUU...................... 3 1 hsa-mir-337_R01_M ESC_WT_454 ..................................................................CAGCUCCUAUAUGAUGCCUUU......................... 2 1 hsa-mir-337_R02 ESC_WT_454 ...................................................................AGCUCCUAUAUGAUGCCUUUC........................ 1 1 hsa-mir-337_R03 ESC_WT_454 ...................................................................AGCUCCUAUAUGAUGCCUUU......................... 1 1 hsa-mir-337_R04 ESC_WT_454 ...................................................................AGCUCCUAUAUGAUGCCUUUCU....................... 1 1 hsa-mir-337_R05 ESC_WT_454 hsa-mir-339 chr7:1029075-1029208 - CUCCGCAGGGGCGGGGCGGCCGCUCUCCCUGUCCUCCAGGAGCUCACGUGUGCCUGCCUGUGAGCGCCUCGACGACAGAGCCGGCGCCUGCCCCAGUGUCUGCGCCGGGACCAUG (((((((((.(((((((((.((((..(.(((((.((.(((.(((((((.((....)).))))))).))).)).))))).)..)))).))))))).)).))))))..)))...... (-61.60) .........................UCCCUGUCCUCCAGGAGCUCA..................................................................... 7 1 hsa-mir-339_L01_M ESC_WT_454 .........................UCCCUGUCCUCCAGGAGCUCACG................................................................... 2 1 hsa-mir-339_L02 ESC_WT_454 hsa-mir-33a chr22:40626874-40626982 + GGCGGGCAGCUGUGGUGCAUUGUAGUUGCAUUGCAUGUUCUGGUGGUACCCAUGCAAUGUUUCCACAGUGCAUCACAGAGGCCUGCCU (((((((..((((((((((((((.(..((((((((((....((.....))))))))))))..).))))))))))))))..))))))). (-56.10) ......................................................CAAUGUUUCCACAGUGCAUCA............. 2 1 hsa-mir-33a_R01_M ESC_WT_454 ......................................................CAAUGUUUCCACAGUGCAUC.............. 2 1 hsa-mir-33a_R02 ESC_WT_454 hsa-mir-340 chr5:179374889-179375023 - UUCUAAAACCGUUUGUACCUGGUGUGAUUAUAAAGCAAUGAGACUGAUUGUCAUAUGUCGUUUGUGGGAUCCGUCUCAGUUACUUUAUAGCCAUACCUGGUAUCUUAUACCACAGA ..............(((((.((((((..(((((((...((((((.((((.(((((.......))))))))).))))))....)))))))..)))))).)))))............. (-36.00) ...........................UUAUAAAGCAAUGAGACUGAUU................................................................... 5 1 hsa-mir-340_L01_M ESC_WT_454 ...........................UUAUAAAGCAAUGAGACUGAU.................................................................... 1 1 hsa-mir-340_L02 ESC_WT_454 .....................................................................UCCGUCUCAGUUACUUUAUAGC......................... 1 1 hsa-mir-340_R01*_M ESC_WT_454 hsa-mir-342 chr14:99645725-99645863 + CCAACCUGUGAAACUGGGCUCAAGGUGAGGGGUGCUAUCUGUGAUUGAGGGACAUGGUUAAUGGAAUUGUCUCACACAGAAAUCGCACCCGUCACCUUGGCCUACUUAUCACCACCCC .......((((((.(((((.((((((((.((((((..((((((.....((((((...((....))..)))))).))))))....)))))).))))))))))))).)).))))...... (-51.40) ...........................AGGGGUGCUAUCUGUGAUUGAGGGACA................................................................ 3 1 hsa-mir-342_L01_M ESC_WT_454 ...........................AGGGGUGCUAUCUGUGAUUGAGGGAC................................................................. 3 1 hsa-mir-342_L02 ESC_WT_454 ...........................AGGGGUGCUAUCUGUGAUUGAGGGA.................................................................. 2 1 hsa-mir-342_L03 ESC_WT_454 ............................GGGGUGCUAUCUGUGAUUGAGG.................................................................... 2 1 hsa-mir-342_L04 ESC_WT_454 ...........................AGGGGUGCUAUCUGUGAUUGAGGG................................................................... 2 1 hsa-mir-342_L05 ESC_WT_454 ............................GGGGUGCUAUCUGUGAUUGAG..................................................................... 2 1 hsa-mir-342_L06 ESC_WT_454 ...........................AGGGGUGCUAUCUGUGAUUGAGGGAC................................................................. 1 1 hsa-mir-342_L07 ESC_DGCR8_454 ...........................AGGGGUGCUAUCUGUGAUUGAG..................................................................... 1 1 hsa-mir-342_L08 ESC_DGCR8_454 ...........................AGGGGUGCUAUCUGUGAUUGAG..................................................................... 1 1 hsa-mir-342_L09 ESC_WT_454 ............................GGGGUGCUAUCUGUGAUUGAGGGAC................................................................. 1 1 hsa-mir-342_L10 ESC_WT_454 ............................GGGGUGCUAUCUGUGAUUGAGGGACA................................................................ 1 1 hsa-mir-342_L11 ESC_WT_454 .....................................................................UCUCACACAGAAAUCGCACCCGU.......................... 3 1 hsa-mir-342_R01*_M ESC_WT_454 .....................................................................UCUCACACAGAAAUCGCACCCGUC......................... 2 1 hsa-mir-342_R02* ESC_WT_454 .......................................................................UCACACAGAAAUCGCACCCGUC......................... 1 1 hsa-mir-342_R03* ESC_WT_454 .....................................................................UCUCACACAGAAAUCGCACCCGUCA........................ 1 1 hsa-mir-342_R04* ESC_WT_454 hsa-mir-34a chr1:9134294-9134443 - GCCGUGGACCGGCCAGCUGUGAGUGUUUCUUUGGCAGUGUCUUAGCUGGUUGUUGUGAGCAAUAGUAAGGAAGCAAUCAGCAAGUAUACUGCCCUAGAAGUGCUGCACGUUGUGGGGCCCAAGAGGGAAGAUG .((.(((.((.((.(((.(((((..(((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..)))))..)).)))))))).))..)))...))....... (-55.70) ...............................UGGCAGUGUCUUAGCUGGUUGU................................................................................ 163 1 hsa-mir-34a_L01_M ESC_WT_454 ...............................UGGCAGUGUCUUAGCUGGUUGUU............................................................................... 110 1 hsa-mir-34a_L02 ESC_WT_454 ...............................UGGCAGUGUCUUAGCUGGUUG................................................................................. 28 1 hsa-mir-34a_L03 ESC_WT_454 ...............................UGGCAGUGUCUUAGCUGGUUGUU............................................................................... 3 1 hsa-mir-34a_L04 ESC_DGCR8_454 ...............................UGGCAGUGUCUUAGCUGGUUGU................................................................................ 3 1 hsa-mir-34a_L05 ESC_DGCR8_454 ...............................UGGCAGUGUCUUAGCUGG.................................................................................... 2 1 hsa-mir-34a_L06 ESC_WT_454 ...............................UGGCAGUGUCUUAGCUGGUUGUUG.............................................................................. 2 1 hsa-mir-34a_L07 ESC_WT_454 ................................GGCAGUGUCUUAGCUGGUUGU................................................................................ 1 1 hsa-mir-34a_L08 ESC_WT_454 ...................................AGUGUCUUAGCUGGUUGU................................................................................ 1 1 hsa-mir-34a_L09 ESC_WT_454 ..............................UUGGCAGUGUCUUAGCUGGUUGUU............................................................................... 1 1 hsa-mir-34a_L10 ESC_WT_454 .................................GCAGUGUCUUAGCUGGUUGU................................................................................ 1 1 hsa-mir-34a_L11 ESC_WT_454 .........................................................................CAAUCAGCAAGUAUACUGCCCUA..................................... 1 1 hsa-mir-34a_R01*_M ESC_WT_454 hsa-mir-34b chr11:110888853-110888976 + CGGGUGCCCGGUGCUCGGUUUGUAGGCAGUGUCAUUAGCUGAUUGUACUGUGGUGGUUACAAUCACUAACUCCACUGCCAUCAAAACAAGGCACAGCAUCACCG ..(((((...(((((..((((...(((((((...((((.((((((((((.....)).))))))))))))...)))))))....))))..))))).))))).... (-42.30) ............................................................AAUCACUAACUCCACUGCCAUC...................... 2 1 hsa-mir-34b_R01_M ESC_WT_454 hsa-mir-34c chr11:110889354-110889470 + UUUUUUCUAUGAGUCUAGUUACUAGGCAGUGUAGUUAGCUGAUUGCUAAUAGUACCAAUCACUAACCACACGGCCAGGUAAAAAGAUUUGGGAAUUCG ...(((((..((((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..))))))))))).... (-34.10) .......................AGGCAGUGUAGUUAGCUGAUUGC.................................................... 1 1 hsa-mir-34c_L01_M ESC_WT_454 hsa-mir-361 chrX:85045277-85045388 - CUGGGAUUUGGGAGCUUAUCAGAAUCUCCAGGGGUACUUUAUAAUUUCAAAAAGUCCCCCAGGUGUGAUUCUGAUUUGCUUCCUUUUCCUC ..((((...((((((..(((((((((.((.((((.(((((..........))))).)))).))...)))))))))..))))))...)))). (-41.90) ...............UUAUCAGAAUCUCCAGGGGUAC...................................................... 12 1 hsa-mir-361_L01_M ESC_WT_454 ...............UUAUCAGAAUCUCCAGGGGU........................................................ 2 1 hsa-mir-361_L02 ESC_WT_454 ..............CUUAUCAGAAUCUCCAGGGGUAC...................................................... 1 1 hsa-mir-361_L03 ESC_WT_454 ......................................................UCCCCCAGGUGUGAUUCUGAUUU.............. 1 1 hsa-mir-361_R01*_M ESC_WT_454 ......................................................UCCCCCAGGUGUGAUUCUGAUUUG............. 1 1 hsa-mir-361_R02* ESC_WT_454 .......................................................CCCCCAGGUGUGAUUCUGAUUUG............. 1 1 hsa-mir-361_R03* ESC_WT_454 hsa-mir-362 chrX:49660292-49660396 + GCUCCCCCUCUUGAAUCCUUGGAACCUAGGUGUGAGUGCUAUUUCAGUGCAACACACCUAUUCAAGGAUUCAAAGAGGCUGAGC ((((..(((((((((((((((((...((((((((.(..((.....))..)..))))))))))))))))))).))))))..)))) (-44.10) .............AAUCCUUGGAACCUAGGUGUG.................................................. 3 1 hsa-mir-362_L01_M ESC_WT_454 hsa-mir-363 chrX:133131054-133131168 - UCUGUUUUGCUGUUGUCGGGUGGAUCACGAUGCAAUUUUGAUGAGUAUCAUAGGAGAAAAAUUGCACGGUAUCCAUCUGUAAACCGCAGGACCU ...(((((((.(((..(((((((((..((.(((((((((.(((.....)))......)))))))))))..)))))))))..))).))))))).. (-35.10) ............................................................AUUGCACGGUAUCCAUCUGUA............. 6 1 hsa-mir-363_R01_M ESC_WT_454 ...........................................................AAUUGCACGGUAUCCAUCUGUA............. 3 1 hsa-mir-363_R02 ESC_WT_454 ...........................................................AAUUGCACGGUAUCCAUCUGU.............. 3 1 hsa-mir-363_R03 ESC_WT_454 ............................................................AUUGCACGGUAUCCAUCUGUAA............ 2 1 hsa-mir-363_R04 ESC_WT_454 ..........................................................AAAUUGCACGGUAUCCAUCUGU.............. 1 1 hsa-mir-363_R05 ESC_WT_454 .............................................................UUGCACGGUAUCCAUCUGU.............. 1 1 hsa-mir-363_R06 ESC_WT_454 hsa-mir-365-1 chr16:14310623-14310749 + CUGGUUCGUUACCGCAGGGAAAAUGAGGGACUUUUGGGGGCAGAUGUGUUUCCAUUCCACUAUCAUAAUGCCCCUAAAAAUCCUUAUUGCUCUUGCAGUAUUCCUCG ..((.....(((.((((((..((((((((..(((((((((((((((((.........))).)))....))))))))))).))))))))..)))))).)))..))... (-38.00) .................................................................UAAUGCCCCUAAAAAUCCUUAU.................... 2 2 hsa-mir-365-1_R01_M ESC_WT_454 .................................................................UAAUGCCCCUAAAAAUCCUUAUU................... 1 2 hsa-mir-365-1_R02 ESC_WT_454 hsa-mir-365-2 chr17:26926523-26926673 + CCUCACCUGGAGAGUGUUCAAGGACAGCAAGAAAAAUGAGGGACUUUCAGGGGCAGCUGUGUUUUCUGACUCAGUCAUAAUGCCCCUAAAAAUCCUUAUUGUUCUUGCAGUGUGCAUCGGGCAGCGGCCAG ......((((...((((((..(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))))))..)))))))).)))))))..))).)...))))).)..)))) (-48.60) .............................................................................UAAUGCCCCUAAAAAUCCUUAU................................ 2 2 hsa-mir-365-2_R01_M ESC_WT_454 .............................................................................UAAUGCCCCUAAAAAUCCUUAUU............................... 1 2 hsa-mir-365-2_R02 ESC_WT_454 hsa-mir-367 chr4:113788459-113788566 - UCUUGGCUACAGGCCAUUACUGUUGCUAAUAUGCAACUCUGUUGAAUAUAAAUUGGAAUUGCACUUUAGCAAUGGUGAUGGAUUGUUAAG .((((((......((((((((((((((((..(((((.((((............)))).)))))..))))))))))))))))...)))))) (-33.90) .........................................................AUUGCACUUUAGCAAUGGUGA............ 1 1 hsa-mir-367_R01_M ESC_WT_454 ..........................................................UUGCACUUUAGCAAUGGUGA............ 1 1 hsa-mir-367_R02 ESC_WT_454 hsa-mir-369 chr14:100601668-100601777 + UCCUGGUACUUGAAGGGAGAUCGACCGUGUUAUAUUCGCUUUAUUGACUUCGAAUAAUACAUGGUUGAUCUUUUCUCAGUAUCAAAUCUC ...(((((((.((..(((((((((((((((..((((((............))))))..)))))))))))))))..)))))))))...... (-36.00) .................AGAUCGACCGUGUUAUAUUCGC................................................... 8 1 hsa-mir-369_L01*_M ESC_WT_454 .................AGAUCGACCGUGUUAUAUUCG.................................................... 3 1 hsa-mir-369_L02* ESC_WT_454 ..................GAUCGACCGUGUUAUAUUCGC................................................... 2 1 hsa-mir-369_L03* ESC_WT_454 .................AGAUCGACCGUGUUAUAUUC..................................................... 1 1 hsa-mir-369_L04* ESC_WT_454 .....................CGACCGUGUUAUAUUCGC................................................... 1 1 hsa-mir-369_L05* ESC_WT_454 ....................................................AAUAAUACAUGGUUGAUCUUU................. 27 1 hsa-mir-369_R01_M ESC_WT_454 ...................................................GAAUAAUACAUGGUUGAUCUUU................. 2 1 hsa-mir-369_R02 ESC_WT_454 ....................................................AAUAAUACAUGGUUGAUCUUUU................ 1 1 hsa-mir-369_R03 ESC_WT_454 hsa-mir-370 chr14:100447209-100447323 + UCGGGGCACAAGACAGAGAAGCCAGGUCACGUCUCUGCAGUUACACAGCUCACGAGUGCCUGCUGGGGUGGAACCUGGUCUGUCUGUCUGUCUAA ...(((((...((((((.(..((((((..(..(((.((((.(((.(.......).))).)))).)))..)..))))))..).))))))))))).. (-41.70) ......................CAGGUCACGUCUCUGCAGUUACAC................................................. 2 1 hsa-mir-370_L01*_M ESC_WT_454 ......................CAGGUCACGUCUCUGCAGUUA.................................................... 1 1 hsa-mir-370_L02* ESC_WT_454 ......................CAGGUCACGUCUCUGCAGUUACA.................................................. 1 1 hsa-mir-370_L03* ESC_WT_454 .........................................................GCCUGCUGGGGUGGAACCUGGU................ 50 1 hsa-mir-370_R01_M ESC_WT_454 ........................................................UGCCUGCUGGGGUGGAACCUGGU................ 3 1 hsa-mir-370_R02 ESC_WT_454 ..........................................................CCUGCUGGGGUGGAACCUGGU................ 3 1 hsa-mir-370_R03 ESC_WT_454 ............................................................UGCUGGGGUGGAACCUGGU................ 1 1 hsa-mir-370_R04 ESC_DGCR8_454 ........................................................UGCCUGCUGGGGUGGAACCU................... 1 1 hsa-mir-370_R05 ESC_WT_454 .........................................................GCCUGCUGGGGUGGAACCUG.................. 1 1 hsa-mir-370_R06 ESC_WT_454 .........................................................GCCUGCUGGGGUGGAACCUGG................. 1 1 hsa-mir-370_R07 ESC_WT_454 .............................................................GCUGGGGUGGAACCUGGU................ 1 1 hsa-mir-370_R08 ESC_WT_454 hsa-mir-374b chrX:73355087-73355198 - AAGAAAUCCUACUCGGAUGGAUAUAAUACAACCUGCUAAGUGUCCUAGCACUUAGCAGGUUGUAUUAUCAUUGUCCGUGUCUAUGGCUCUC .(((...((.((.((((..(..(((((((((((((((((((((....)))))))))))))))))))))..)..)))).))....)).))). (-42.80) ....................AUAUAAUACAACCUGCUAAGUG................................................. 68 1 hsa-mir-374b_L01_M ESC_WT_454 ....................AUAUAAUACAACCUGCUAAGU.................................................. 5 1 hsa-mir-374b_L02 ESC_WT_454 ....................AUAUAAUACAACCUGCUAAGUGU................................................ 4 1 hsa-mir-374b_L03 ESC_WT_454 .......................UAAUACAACCUGCUAAGUG................................................. 2 1 hsa-mir-374b_L04 ESC_WT_454 .....................UAUAAUACAACCUGCUAAGUG................................................. 2 1 hsa-mir-374b_L05 ESC_WT_454 ......................AUAAUACAACCUGCUAAGUG................................................. 1 1 hsa-mir-374b_L06 ESC_WT_454 ....................AUAUAAUACAACCUGCUAAG................................................... 1 1 hsa-mir-374b_L07 ESC_WT_454 hsa-mir-375 chr2:219574591-219574694 - UCCGCUCCCGCCCCGCGACGAGCCCCUCGCACAAACCGGACCUGAGCGUUUUGUUCGUUCGGCUCGCGUGAGGCAGGGGCGGC .(((((((.(((.((((.((((((...((.(((((.((........)).))))).))...)))))))))).))).))))))). (-45.20) .................................................UUUGUUCGUUCGGCUCGCGUGA............ 2 1 hsa-mir-375_R01_M ESC_WT_454 hsa-mir-376a-1 chr14:100576852-100576959 + UUUGGUAUUUAAAAGGUAGAUUCUCCUUCUAUGAGUACAUUAUUUAUGAUUAAUCAUAGAGGAAAAUCCACGUUUUCAGUAUCAAAU (((((((((.((((.((.((((.((((.((((((...(((.....))).....)))))))))).)))).)).)))).))))))))). (-26.90) ................UAGAUUCUCCUUCUAUGAGUA.................................................. 4 1 hsa-mir-376a-1_L01_M ESC_WT_454 ..............GGUAGAUUCUCCUUCUAUGAGU................................................... 3 1 hsa-mir-376a-1_L02 ESC_WT_454 ...............GUAGAUUCUCCUUCUAUGAGUA.................................................. 2 1 hsa-mir-376a-1_L03 ESC_WT_454 ..............GGUAGAUUCUCCUUCUAUGAGUA.................................................. 1 1 hsa-mir-376a-1_L04 ESC_WT_454 hsa-mir-377 chr14:100598120-100598228 + GUUUGACCCUUGAGCAGAGGUUGCCCUUGGUGAAUUCGCUUUAUUUAUGUUGAAUCACACAAAGGCAACUUUUGUUUGAGUAUCAAAU ((((((..((..(((((((((((((.(((((((.(((((.........).)))))))).))).)))))))))))))..))..)))))) (-37.70) ...............AGAGGUUGCCCUUGGUGAAUUC................................................... 7 1 hsa-mir-377_L01*_M ESC_WT_454 ...............AGAGGUUGCCCUUGGUGAAUU.................................................... 1 1 hsa-mir-377_L02* ESC_WT_454 ...............AGAGGUUGCCCUUGGUGAAUUCG.................................................. 1 1 hsa-mir-377_L03* ESC_WT_454 .....................................................AUCACACAAAGGCAACUUUUGU............. 29 1 hsa-mir-377_R01_M ESC_WT_454 ..................................................UGAAUCACACAAAGGCAACUUUU............... 4 1 hsa-mir-377_R02 ESC_WT_454 ....................................................AAUCACACAAAGGCAACUUUUGU............. 1 1 hsa-mir-377_R03 ESC_WT_454 .......................................................CACACAAAGGCAACUUUUG.............. 1 1 hsa-mir-377_R04 ESC_WT_454 hsa-mir-378 chr5:149092561-149092666 + GAGCCACCCAGGGCUCCUGACUCCAGGUCCUGUGUGUUACCUAGAAAUAGCACUGGACUUGGAGUCAGAAGGCCUGAGUGGAGUC ...((((.((((.((.((((((((((((((...((((((........)))))).)))))))))))))).)).)))).)))).... (-50.40) .............CUCCUGACUCCAGGUCCUGUGU.................................................. 8 1 hsa-mir-378_L01_M ESC_WT_454 ...................................................ACUGGACUUGGAGUCAGAAGG............. 4 1 hsa-mir-378_R01*_M ESC_WT_454 ...................................................ACUGGACUUGGAGUCAGAAGGC............ 2 1 hsa-mir-378_R02* ESC_WT_454 hsa-mir-379 chr14:100558136-100558242 + GGUUCCUGAAGAGAUGGUAGACUAUGGAACGUAGGCGUUAUGAUUUCUGACCUAUGUAACAUGGUCCACUAACUCUCAGUAUCCAA ((...((((.(((.((((.(((((((..(((((((((..(....)..)).)))))))..))))))).)))).)))))))...)).. (-33.60) ..............UGGUAGACUAUGGAACGUAGG................................................... 186 1 hsa-mir-379_L01_M ESC_WT_454 ..............UGGUAGACUAUGGAACGUAG.................................................... 8 1 hsa-mir-379_L02 ESC_WT_454 ..............UGGUAGACUAUGGAACGUAGG................................................... 5 1 hsa-mir-379_L03 ESC_DGCR8_454 .............AUGGUAGACUAUGGAACGUAGG................................................... 4 1 hsa-mir-379_L04 ESC_WT_454 ..............UGGUAGACUAUGGAACGUAGGC.................................................. 2 1 hsa-mir-379_L05 ESC_WT_454 ..............UGGUAGACUAUGGAACGUAG.................................................... 1 1 hsa-mir-379_L06 ESC_DGCR8_454 .................UAGACUAUGGAACGUAGG................................................... 1 1 hsa-mir-379_L07 ESC_WT_454 ..............UGGUAGACUAUGGAACGUA..................................................... 1 1 hsa-mir-379_L08 ESC_WT_454 ....................................................UAUGUAACAUGGUCCACUAAC............. 27 1 hsa-mir-379_R01*_M ESC_WT_454 ....................................................UAUGUAACAUGGUCCACUAA.............. 12 1 hsa-mir-379_R02* ESC_WT_454 ....................................................UAUGUAACAUGGUCCACUAAC............. 3 1 hsa-mir-379_R03* ESC_DGCR8_454 .....................................................AUGUAACAUGGUCCACUAAC............. 1 1 hsa-mir-379_R04* ESC_WT_454 ....................................................UAUGUAACAUGGUCCACUA............... 1 1 hsa-mir-379_R05* ESC_WT_454 hsa-mir-381 chr14:100581990-100582104 + AUUGUUUGGUACUUAAAGCGAGGUUGCCCUUUGUAUAUUCGGUUUAUUGACAUGGAAUAUACAAGGGCAAGCUCUCUGUGAGUAUCAAACCUUGU ...((((((((((((.((.(((.((((((((.((((((((.(((....)))...)))))))))))))))).))).)).))))))))))))..... (-45.30) ................AGCGAGGUUGCCCUUUGUAUAUU........................................................ 5 1 hsa-mir-381_L01*_M ESC_WT_454 .........................................................UAUACAAGGGCAAGCUCUCUGU................ 95 1 hsa-mir-381_R01_M ESC_WT_454 .........................................................UAUACAAGGGCAAGCUCUCUG................. 7 1 hsa-mir-381_R02 ESC_WT_454 ........................................................AUAUACAAGGGCAAGCUCUCUGU................ 2 1 hsa-mir-381_R03 ESC_WT_454 .........................................................UAUACAAGGGCAAGCUCUCUGU................ 1 1 hsa-mir-381_R04 ESC_DGCR8_454 .......................................................AAUAUACAAGGGCAAGCUCUCUGU................ 1 1 hsa-mir-381_R05 ESC_WT_454 hsa-mir-382 chr14:100590376-100590491 + UUUCUGUGGUACUUGAAGAGAAGUUGUUCGUGGUGGAUUCGCUUUACUUAUGACGAAUCAUUCACGGACAACACUUUUUUCAGUACCAAAUGCUA ......(((((((.(((((((.(((((((((((..(((((((.........).))))))..)))))))))))..))))))))))))))....... (-37.10) ...................GAAGUUGUUCGUGGUGGAUUCG...................................................... 331 1 hsa-mir-382_L01_M ESC_WT_454 ....................AAGUUGUUCGUGGUGGAUUCG...................................................... 16 1 hsa-mir-382_L02 ESC_WT_454 ...................GAAGUUGUUCGUGGUGGAUUC....................................................... 10 1 hsa-mir-382_L03 ESC_WT_454 ..................AGAAGUUGUUCGUGGUGGAUUCG...................................................... 8 1 hsa-mir-382_L04 ESC_WT_454 .....................AGUUGUUCGUGGUGGAUUCGCU.................................................... 6 1 hsa-mir-382_L05 ESC_WT_454 .....................AGUUGUUCGUGGUGGAUUCGC..................................................... 6 1 hsa-mir-382_L06 ESC_WT_454 ...................GAAGUUGUUCGUGGUGGAUUCG...................................................... 2 1 hsa-mir-382_L07 ESC_DGCR8_454 ...................GAAGUUGUUCGUGGUGGAUU........................................................ 2 1 hsa-mir-382_L08 ESC_WT_454 .....................AGUUGUUCGUGGUGGAUUCG...................................................... 2 1 hsa-mir-382_L09 ESC_WT_454 .......................................................AAUCAUUCACGGACAACACUUU.................. 3 1 hsa-mir-382_R01*_M ESC_WT_454 .........................................................UCAUUCACGGACAACACUUUU................. 3 1 hsa-mir-382_R02* ESC_WT_454 ...........................................................AUUCACGGACAACACUUU.................. 1 1 hsa-mir-382_R03* ESC_WT_454 hsa-mir-409 chr14:100601370-100601488 + GCCUCUCCAUGGUACUCGGGGAGAGGUUACCCGAGCAACUUUGCAUCUGGACGACGAAUGUUGCUCGGUGAACCCCUUUUCGGUAUCAAAUUCCACCA .........((((((.((..(((.((((..((((((((((((((........).)))).)))))))))..)))).)))..)))))))).......... (-39.30) .......................AGGUUACCCGAGCAACUUUGCAUC................................................... 5 1 hsa-mir-409_L01*_M ESC_WT_454 .......................AGGUUACCCGAGCAACUUUGCAUCU.................................................. 2 1 hsa-mir-409_L02* ESC_WT_454 .......................AGGUUACCCGAGCAACUUUGCAU.................................................... 2 1 hsa-mir-409_L03* ESC_WT_454 .......................AGGUUACCCGAGCAACUUUGC...................................................... 1 1 hsa-mir-409_L04* ESC_WT_454 ......................................................CGAAUGUUGCUCGGUGAACCCCU..................... 14 1 hsa-mir-409_R01_M ESC_WT_454 .......................................................GAAUGUUGCUCGGUGAACCCCU..................... 11 1 hsa-mir-409_R02 ESC_WT_454 .......................................................GAAUGUUGCUCGGUGAACCCC...................... 4 1 hsa-mir-409_R03 ESC_WT_454 ......................................................CGAAUGUUGCUCGGUGAACCCC...................... 2 1 hsa-mir-409_R04 ESC_WT_454 ........................................................AAUGUUGCUCGGUGAACCCCU..................... 2 1 hsa-mir-409_R05 ESC_WT_454 ......................................................CGAAUGUUGCUCGGUGAACCCCUU.................... 1 1 hsa-mir-409_R06 ESC_WT_454 .......................................................GAAUGUUGCUCGGUGAACCCCUU.................... 1 1 hsa-mir-409_R07 ESC_WT_454 hsa-mir-410 chr14:100601982-100602101 + GGCACUCUGGGUACCUGAGAAGAGGUUGUCUGUGAUGAGUUCGCUUUUAUUAAUGACGAAUAUAACACAGAUGGCCUGUUUUCAGUACCGCUACCGCCCGG (((.....((((((.((((((.((((..((((((.((.((((((..........).))))).)).))))))..)))).))))))))))).)....)))... (-41.50) ......................AGGUUGUCUGUGAUGAGUUCG.......................................................... 8 1 hsa-mir-410_L01_M ESC_WT_454 ......................AGGUUGUCUGUGAUGAGUUC........................................................... 1 1 hsa-mir-410_L02 ESC_WT_454 ..........................................................AAUAUAACACAGAUGGCCUGU...................... 5 1 hsa-mir-410_R01*_M ESC_WT_454 ............................................................UAUAACACAGAUGGCCUGU...................... 2 1 hsa-mir-410_R02* ESC_WT_454 ...........................................................AUAUAACACAGAUGGCCUGU...................... 2 1 hsa-mir-410_R03* ESC_WT_454 .............................................................AUAACACAGAUGGCCUGU...................... 1 1 hsa-mir-410_R04* ESC_WT_454 ............................................................UAUAACACAGAUGGCCUGUUUU................... 1 1 hsa-mir-410_R05* ESC_WT_454 ..........................................................AAUAUAACACAGAUGGCCUG....................... 1 1 hsa-mir-410_R06* ESC_WT_454 hsa-mir-411 chr14:100559395-100559530 + AUCUCUGUGUGGUACUUGGAGAGAUAGUAGACCGUAUAGCGUACGCUUUAUCUGUGACGUAUGUAACACGGUCCACUAACCCUCAGUAUCAAAUCCAUCCCCGAGGCUCCUGGAA .........(((((((..(((.(.((((.((((((.(.((((((((.........).))))))).).)))))).)))).).))))))))))..((((.((....))....)))). (-34.00) ........................UAGUAGACCGUAUAGCGUACG...................................................................... 46 1 hsa-mir-411_L01_M ESC_WT_454 .......................AUAGUAGACCGUAUAGCGUACG...................................................................... 9 1 hsa-mir-411_L02 ESC_WT_454 ........................UAGUAGACCGUAUAGCGUAC....................................................................... 2 1 hsa-mir-411_L03 ESC_WT_454 ...........................UAGACCGUAUAGCGUACG...................................................................... 1 1 hsa-mir-411_L04 ESC_WT_454 ...........................................................UAUGUAACACGGUCCACUAAC................................... 29 1 hsa-mir-411_R01*_M ESC_WT_454 ...........................................................UAUGUAACACGGUCCACUAA.................................... 5 1 hsa-mir-411_R02* ESC_WT_454 ...........................................................UAUGUAACACGGUCCACUAACC.................................. 2 1 hsa-mir-411_R03* ESC_WT_454 ...........................................................UAUGUAACACGGUCCACUA..................................... 2 1 hsa-mir-411_R04* ESC_WT_454 ............................................................AUGUAACACGGUCCACUAA.................................... 1 1 hsa-mir-411_R05* ESC_WT_454 hsa-mir-421 chrX:73354917-73355041 - CUAAUCCGGUGCACAUUGUAGGCCUCAUUAAAUGUUUGUUGAAUGAAAAAAUGAAUCAUCAACAGACAUUAAUUGGGCGCCUGCUCUGUGAUCUCCAUGGGCUC ....(((((..((((..((((((((((...((((((((((((.(((.........)))))))))))))))...)))).))))))..))))....))..)))... (-38.30) CUAAUCCGGUGCACAUUGUAGGC................................................................................. 1 1 hsa-mir-421_L01*_M ESC_WT_454 ....UCCGGUGCACAUUGUAGGC................................................................................. 1 1 hsa-mir-421_L02* ESC_WT_454 ..........................................................UCAACAGACAUUAAUUGGGCGC........................ 2 1 hsa-mir-421_R01_M ESC_WT_454 .........................................................AUCAACAGACAUUAAUUGGGCG......................... 1 1 hsa-mir-421_R02 ESC_WT_454 hsa-mir-423 chr17:25468203-25468336 + UGUGAGGAAAUAAAGGAAGUUAGGCUGAGGGGCAGAGAGCGAGACUUUUCUAUUUUCCAAAAGCUCGGUCUGAGGCCCCUCAGUCUUGCUUCCUAACCCGCGCUUGAGUUUCU .(((.((......(((((((.((((((((((((..(((.((((.(((((.........))))))))).)))...)))))))))))).)))))))...)).))).......... (-52.20) .........................UGAGGGGCAGAGAGCGAGACUUU................................................................. 5 1 hsa-mir-423_L01_M ESC_WT_454 .........................UGAGGGGCAGAGAGCGAGACUU.................................................................. 2 1 hsa-mir-423_L02 ESC_WT_454 .........................UGAGGGGCAGAGAGCGAGACUUUU................................................................ 1 1 hsa-mir-423_L03 ESC_WT_454 .............................................................AGCUCGGUCUGAGGCCCCUCAGU............................. 3 1 hsa-mir-423_R01*_M ESC_WT_454 hsa-mir-424 chrX:133508290-133508427 - CUUCAUUGACUCCGAGGGGAUACAGCAGCAAUUCAUGUUUUGAAGUGUUCUAAAUGGUUCAAAACGUGAGGCGCUGCUAUACCCCCUCGUGGGGAAGGUAGAAGGUGGGGUCUGCCGGA .........((((((((((.((.((((((..(((((((((((((.(((.....))).)))))))))))))..)))))).)).))))))).)))...((((((........))))))... (-54.50) ......................CAGCAGCAAUUCAUGUUUUG............................................................................. 4 1 hsa-mir-424_L01_M ESC_WT_454 hsa-mir-425 chr3:49032565-49032691 - CUUCAGAAUGGAAAGCGCUUUGGAAUGACACGAUCACUCCCGUUGAGUGGGCACCCGAGAAGCCAUCGGGAAUGUCGUGUCCGCCCAGUGCUCUUUCGGCGCCUCCC ..........(((((.((.((((...(((((((((((((.....)))))....(((((.......)))))...))))))))...)))).)).))))).......... (-38.00) .......................AAUGACACGAUCACUCCCGUUGA............................................................. 6 1 hsa-mir-425_L01_M ESC_WT_454 .........................UGACACGAUCACUCCCGUUGAGU........................................................... 3 1 hsa-mir-425_L02 ESC_WT_454 .......................AAUGACACGAUCACUCCCGUUGAG............................................................ 2 1 hsa-mir-425_L03 ESC_WT_454 .......................AAUGACACGAUCACUCCCGUUGAGU........................................................... 2 1 hsa-mir-425_L04 ESC_WT_454 ........................AUGACACGAUCACUCCCGUUGAG............................................................ 1 1 hsa-mir-425_L05 ESC_WT_454 .......................AAUGACACGAUCACUCCCGUUGAGUGG......................................................... 1 1 hsa-mir-425_L06 ESC_WT_454 ............................CACGAUCACUCCCGUUGAG............................................................ 1 1 hsa-mir-425_L07 ESC_WT_454 ......................GAAUGACACGAUCACUCCCGUUG.............................................................. 1 1 hsa-mir-425_L08 ESC_WT_454 .................................................................UCGGGAAUGUCGUGUCCGC....................... 1 1 hsa-mir-425_R01*_M ESC_WT_454 hsa-mir-431 chr14:100417077-100417230 + ACGUCGUUGUCCUGCUUGUCCUGCGAGGUGUCUUGCAGGCCGUCAUGCAGGCCACACUGACGGUAACGUUGCAGGUCGUCUUGCAGGGCUUCUCGCAAGACGACAUCCUCAUCACCAACGACGUGCAGCUCCA (((((((((........((((((((((..(.(((((.((((........)))).....((((....))))))))).)..)))))))))).((((....)).))............)))))))))......... (-56.00) ............................UGUCUUGCAGGCCGUCAUGCA.................................................................................... 64 1 hsa-mir-431_L01_M ESC_WT_454 ............................UGUCUUGCAGGCCGUCAUGC..................................................................................... 16 1 hsa-mir-431_L02 ESC_WT_454 ............................UGUCUUGCAGGCCGUCAUGCAGG.................................................................................. 10 1 hsa-mir-431_L03 ESC_WT_454 ............................UGUCUUGCAGGCCGUCAUGCAG................................................................................... 2 1 hsa-mir-431_L04 ESC_WT_454 ..............................UCUUGCAGGCCGUCAUGCAG................................................................................... 1 1 hsa-mir-431_L05 ESC_WT_454 ............................UGUCUUGCAGGCCGUCAUG...................................................................................... 1 1 hsa-mir-431_L06 ESC_WT_454 .......................................................................CAGGUCGUCUUGCAGGGCUUCU........................................ 5 1 hsa-mir-431_R01*_M ESC_WT_454 .....................................................................UGCAGGUCGUCUUGCAGGGCUUCU........................................ 2 1 hsa-mir-431_R02* ESC_WT_454 .......................................................................CAGGUCGUCUUGCAGGGCUUC......................................... 1 1 hsa-mir-431_R03* ESC_WT_454 .....................................................................UGCAGGUCGUCUUGCAGGGCUUC......................................... 1 1 hsa-mir-431_R04* ESC_WT_454 hsa-mir-433 chr14:100417956-100418088 + ACCCAAUGCCCGGGGAGAAGUACGGUGAGCCUGUCAUUAUUCAGAGAGGCUAGAUCCUCUGUGUUGAGAAGGAUCAUGAUGGGCUCCUCGGUGUUCUCCAGGUAGCGGCACC ..((..((((...((((((...(((.(((((((((((.(((((.(((((......))))).))........))).))))))))))).)))...)))))).))))..)).... (-43.40) ........................................................................AUCAUGAUGGGCUCCUCGGUGU.................. 45 1 hsa-mir-433_R01_M ESC_WT_454 .........................................................................UCAUGAUGGGCUCCUCGGUGU.................. 15 1 hsa-mir-433_R02 ESC_WT_454 ..........................................................................CAUGAUGGGCUCCUCGGUGU.................. 1 1 hsa-mir-433_R03 ESC_WT_454 ........................................................................AUCAUGAUGGGCUCCUCGGUGUU................. 1 1 hsa-mir-433_R04 ESC_WT_454 .......................................................................GAUCAUGAUGGGCUCCUCGGUGU.................. 1 1 hsa-mir-433_R05 ESC_WT_454 hsa-mir-449a chr5:54502097-54502227 - UGAAGUGCUCUGGAUACCUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACAAUGAACAUC ..................((((((..(((((.(((((((((((.((((((((((....(((....)))..)))))))))))))).))))))).)))))..))))))........... (-39.00) ................................UGGCAGUGUAUUGUUAGCUGGU............................................................... 26 1 hsa-mir-449a_L01_M ESC_WT_454 ................................UGGCAGUGUAUUGUUAGCUGGUU.............................................................. 1 1 hsa-mir-449a_L02 ESC_WT_454 hsa-mir-450a-1 chrX:133502017-133502147 - AGGCAAUCAAAAACGAUACUAAACUGUUUUUGCGAUGUGUUCCUAAUAUGCACUAUAAAUAUAUUGGGAACAUUUUGCAUGUAUAGUUUUGUAUCAAUAUACAGAUGAAA ..............(((((.(((((((...(((((.((((((((((((((.........)))))))))))))).)))))...))))))).)))))............... (-35.40) ...........................UUUUGCGAUGUGUUCCUAAUAU............................................................. 11 2 hsa-mir-450a-1_L01_M ESC_WT_454 hsa-mir-450a-2 chrX:133502184-133502323 - AUAAAGGUGACCAAAGAAAGAUGCUAAACUAUUUUUGCGAUGUGUUCCUAAUAUGUAAUAUAAAUGUAUUGGGGACAUUUUGCAUUCAUAGUUUUGUAUCAAUAAUAUGGGGAAAAGAG ..........(((......(((((.(((((((...(((((.(((((((((((((((.......))))))))))))))).)))))...))))))).))))).......)))......... (-36.72) ................................UUUUGCGAUGUGUUCCUAAUAU................................................................. 11 2 hsa-mir-450a-2_L01_M ESC_WT_454 hsa-mir-455 chr9:116011515-116011650 + CUGCGCCCUUCCCUGGCGUGAGGGUAUGUGCCUUUGGACUACAUCGUGGAAGCCAGCACCAUGCAGUCCAUGGGCAUAUACACUUGCCUCAAGGCCUAUGUCAUCGAGGAGCCAC .((.((.((((..(((((((...((((((((((.((((((.(((.(((........))).))).)))))).))))))))))....(((....))).)))))))..)))).)))). (-48.30) ........................UAUGUGCCUUUGGACUACAUCG..................................................................... 3 1 hsa-mir-455_L01_M ESC_WT_454 hsa-mir-484 chr16:15644632-15644750 + CGGCCCUGCAGCCUCGUCAGGCUCAGUCCCCUCCCGAUAAACCCCUAAAUAGGGACUUUCCCGGGGGGUGACCCUGGCUUUUUUGGCGAAAACCCCCA .((.......(((..((((((....(((.(((((((..(((.((((....))))..)))..))))))).)))))))))......)))........)). (-34.86) ................UCAGGCUCAGUCCCCUCCCGAU............................................................ 143 1 hsa-mir-484_L01_M ESC_DGCR8_454 ................UCAGGCUCAGUCCCCUCCCGA............................................................. 51 1 hsa-mir-484_L02 ESC_DGCR8_454 ................UCAGGCUCAGUCCCCUCCCGAU............................................................ 14 1 hsa-mir-484_L03 ESC_WT_454 ................UCAGGCUCAGUCCCCUCCCGAUA........................................................... 13 1 hsa-mir-484_L04 ESC_DGCR8_454 ................UCAGGCUCAGUCCCCUCCCG.............................................................. 8 1 hsa-mir-484_L05 ESC_DGCR8_454 ................UCAGGCUCAGUCCCCUCCCGA............................................................. 8 1 hsa-mir-484_L06 ESC_WT_454 ................UCAGGCUCAGUCCCCUCCCGAUA........................................................... 6 1 hsa-mir-484_L07 ESC_WT_454 ................UCAGGCUCAGUCCCCUCCCGAUAA.......................................................... 3 1 hsa-mir-484_L08 ESC_DGCR8_454 .................CAGGCUCAGUCCCCUCCCGAU............................................................ 2 1 hsa-mir-484_L09 ESC_DGCR8_454 .................CAGGCUCAGUCCCCUCCCGA............................................................. 2 1 hsa-mir-484_L10 ESC_DGCR8_454 ................UCAGGCUCAGUCCCCUCCCGAUAAA......................................................... 1 1 hsa-mir-484_L11 ESC_DGCR8_454 hsa-mir-485 chr14:100591489-100591601 + CCAGUGUUCAUGUGUGGUACUUGGAGAGAGGCUGGCCGUGAUGAAUUCGAUUCAUCAAAGCGAGUCAUACACGGCUCUCCUCUCUUUUAGUGUCAAAUUCU ..............((..(((..((((((((..(((((((((((.((((...........)))))))).)))))))..))))))))..)))..))...... (-39.70) ..........................AGAGGCUGGCCGUGAUGAAUUCG.................................................... 6 1 hsa-mir-485_L01*_M ESC_WT_454 ..............................................................AGUCAUACACGGCUCUCCUCUCU................ 14 1 hsa-mir-485_R01_M ESC_WT_454 ...............................................................GUCAUACACGGCUCUCCUCUCU................ 4 1 hsa-mir-485_R02 ESC_WT_454 hsa-mir-487b chr14:100582525-100582648 + UGCUAACCUUUGGUACUUGGAGAGUGGUUAUCCCUGUCCUGUUCGUUUUGCUCAUGUCGAAUCGUACAGGGUCAUCCACUUUUUCAGUAUCAAGAGCGCAGAC .(((....(((((((((..((((((((....((((((.(.(((((............))))).).))))))....))))))))..))))))))))))...... (-38.40) ............................................................AUCGUACAGGGUCAUCCACUUU..................... 3 1 hsa-mir-487b_R01_M ESC_WT_454 .............................................................UCGUACAGGGUCAUCCACUUU..................... 1 1 hsa-mir-487b_R02 ESC_WT_454 ............................................................AUCGUACAGGGUCAUCCACUU...................... 1 1 hsa-mir-487b_R03 ESC_WT_454 hsa-mir-494 chr14:100565704-100565824 + CUAAUCUUCGAUACUCGAAGGAGAGGUUGUCCGUGUUGUCUUCUCUUUAUUUAUGAUGAAACAUACACGGGAAACCUCUUUUUUAGUAUCAAAUCCCACC .........((((((.((((((((((((..(((((((((.(((((.........)).)))))).))))))..)))))))))))))))))).......... (-36.10) .......................AGGUUGUCCGUGUUGUCUUCUC....................................................... 2 1 hsa-mir-494_L01*_M ESC_WT_454 ........................................................UGAAACAUACACGGGAAACCUCU..................... 71 1 hsa-mir-494_R01_M ESC_WT_454 ........................................................UGAAACAUACACGGGAAACCUC...................... 5 1 hsa-mir-494_R02 ESC_WT_454 .............................................................CAUACACGGGAAACCUCU..................... 3 1 hsa-mir-494_R03 ESC_WT_454 ........................................................UGAAACAUACACGGGAAACCU....................... 3 1 hsa-mir-494_R04 ESC_WT_454 .........................................................GAAACAUACACGGGAAACCUCU..................... 1 1 hsa-mir-494_R05 ESC_WT_454 ...........................................................AACAUACACGGGAAACCUCUUU................... 1 1 hsa-mir-494_R06 ESC_WT_454 ..............................................................AUACACGGGAAACCUCUUU................... 1 1 hsa-mir-494_R07 ESC_WT_454 ........................................................UGAAACAUACACGGGAAACCUCUU.................... 1 1 hsa-mir-494_R08 ESC_WT_454 hsa-mir-495 chr14:100569825-100569946 + GUGCUCAUCUCUGGUACCUGAAAAGAAGUUGCCCAUGUUAUUUUCGCUUUAUAUGUGACGAAACAAACAUGGUGCACUUCUUUUUCGGUAUCAAAUAUCUCCU ...........(((((((.((((((((((.(((((((((..((((((.........).)))))..))))))).)))))))))))).))))))).......... (-36.40) ............................................................AAACAAACAUGGUGCACUUCUUU.................... 23 1 hsa-mir-495_R01_M ESC_WT_454 ............................................................AAACAAACAUGGUGCACUUCUU..................... 18 1 hsa-mir-495_R02 ESC_WT_454 .............................................................AACAAACAUGGUGCACUUCUUU.................... 7 1 hsa-mir-495_R03 ESC_WT_454 ..............................................................ACAAACAUGGUGCACUUCUUU.................... 1 1 hsa-mir-495_R04 ESC_WT_454 ..............................................................ACAAACAUGGUGCACUUCUU..................... 1 1 hsa-mir-495_R05 ESC_WT_454 hsa-mir-496 chr14:100596643-100596784 + AAGCGAGCACCCAAGUCAGGUACUCGAAUGGAGGUUGUCCAUGGUGUGUUCAUUUUAUUUAUGAUGAGUAUUACAUGGCCAAUCUCCUUUCGGUACUCAAUUCUUCUUGGGAAACGUCACG ..(((....((((((...(((((.((((.((((((((.(((((..(((((((((........)))))))))..))))).)))))))).)))))))))........))))))...))).... (-45.20) ................................................................UGAGUAUUACAUGGCCAAUCUC................................... 6 1 hsa-mir-496_R01_M ESC_WT_454 ..................................................................AGUAUUACAUGGCCAAUCUCC.................................. 6 1 hsa-mir-496_R02 ESC_WT_454 ................................................................UGAGUAUUACAUGGCCAAUCU.................................... 1 1 hsa-mir-496_R03 ESC_WT_454 ..................................................................AGUAUUACAUGGCCAAUCUC................................... 1 1 hsa-mir-496_R04 ESC_WT_454 hsa-mir-497 chr17:6861934-6862085 - UCCUUUCAACCCACCCCGGUCCUGCUCCCGCCCCAGCAGCACACUGUGGUUUGUACGGCACUGUGGCCACGUCCAAACCACACUGUGGUGUUAGAGCGAGGGUGGGGGAGGCACCGCCGAGGCUUGGCCCU .....((((.((.(..(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....).)))))))))))).))))..).)).)))).... (-59.10) .................................CAGCAGCACACUGUGGUUUGUA............................................................................ 23 1 hsa-mir-497_L01_M ESC_WT_454 .................................CAGCAGCACACUGUGGUUUGU............................................................................. 9 1 hsa-mir-497_L02 ESC_WT_454 hsa-mir-505 chrX:138833953-138834076 - CCGGUGGUAAAUUGAUGCACCCAGUGGGGGAGCCAGGAAGUAUUGAUGUUUCUGCCAGUUUAGCGUCAACACUUGCUGGUUUCCUCUCUGGAGCAUCGCCAAGUUC ....((((.....(((((..((((.(((((((((((.((((.((((((((...........)))))))).)))).))))))))))).)))).)))))))))..... (-48.80) ...........................GGGAGCCAGGAAGUAUUGAUGUU........................................................ 1 1 hsa-mir-505_L01_M ESC_WT_454 hsa-mir-532 chrX:49654474-49654604 + CAGACCUCCCGACUUGCUUUCUCUCCUCCAUGCCUUGAGUGUAGGACCGUUGGCAUCUUAAUUACCCUCCCACACCCAAGGCUUGCAAAAAAGCGAGCCUUCUCUUCCCU ..........(.((((((((........((.((((((.((((.(((..((.............))..))).)))).)))))).))....)))))))).)........... (-25.72) ............................CAUGCCUUGAGUGUAGGACCGU............................................................ 29 1 hsa-mir-532_L01_M ESC_WT_454 ............................CAUGCCUUGAGUGUAGGACC.............................................................. 1 1 hsa-mir-532_L02 ESC_DGCR8_454 ............................CAUGCCUUGAGUGUAGGACC.............................................................. 1 1 hsa-mir-532_L03 ESC_WT_454 hsa-mir-542 chrX:133503017-133503153 - CAAGGAUGCACAGAUCUCAGACAUCUCGGGGAUCAUCAUGUCACGAGAUACCAGUGUGCACUUGUGACAGAUUGAUAACUGAAAGGUCUGGGAGCCACUCAUCUUCAUAGCAAAAC ..((((((......((((((((...((((..((((...(((((((((.(((....)))..)))))))))...))))..))))...))))))))......))))))........... (-41.20) ........................CUCGGGGAUCAUCAUGUCACGAG..................................................................... 1 1 hsa-mir-542_L01*_M ESC_WT_454 ..............................................................UGUGACAGAUUGAUAACUGAA................................. 3 1 hsa-mir-542_R01_M ESC_WT_454 ..............................................................UGUGACAGAUUGAUAACUGAAAG............................... 3 1 hsa-mir-542_R02 ESC_WT_454 ..............................................................UGUGACAGAUUGAUAACUGA.................................. 1 1 hsa-mir-542_R03 ESC_DGCR8_454 hsa-mir-543 chr14:100568057-100568174 + GACGUGCGGUACUUAAUGAGAAGUUGCCCGUGUUUUUUUCGCUUUAUUUGUGACGAAACAUUCGCGGUGCACUUCUUUUUCAGUAUCCUAUUCUGCC ((.(((.((((((.((.(((((((.(((((((.((((.((((.......)))).))))....))))).))))))))).)).)))))).))))).... (-30.00) .......................................................AAACAUUCGCGGUGCACUUCUU.................... 20 1 hsa-mir-543_R01_M ESC_WT_454 .......................................................AAACAUUCGCGGUGCACUUCUUU................... 7 1 hsa-mir-543_R02 ESC_WT_454 .......................................................AAACAUUCGCGGUGCACUUCU..................... 3 1 hsa-mir-543_R03 ESC_WT_454 .......................................................AAACAUUCGCGGUGCACUUCUUUU.................. 1 1 hsa-mir-543_R04 ESC_WT_454 ...........................................................AUUCGCGGUGCACUUCUUU................... 1 1 hsa-mir-543_R05 ESC_WT_454 ...........................................................AUUCGCGGUGCACUUCUU.................... 1 1 hsa-mir-543_R06 ESC_WT_454 ........................................................AACAUUCGCGGUGCACUUCUU.................... 1 1 hsa-mir-543_R07 ESC_WT_454 hsa-mir-558 chr2:32610704-32610837 + UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUUAUUUUGGUAUAGUAGCUCUAGACUCUAUUAUAGUUUCCUGAGCUGCUGUACCAAAAUACCACAAACGGGCUGGCUUAAAACA ........(((...((.((..((.(((.((((((.((((((((((((((((((..((..(((...)))..))..)))))))))))))))))))))))).))).))..)).))..))) (-46.80) UGUGUGUGUGUGUGUGUG................................................................................................... 1 1 hsa-mir-558_L01_M ESC_DGCR8_454 UGUGUGUGUGUGUGUGUGU.................................................................................................. 1 1 hsa-mir-558_L02 ESC_DGCR8_454 UGUGUGUGUGUGUGUGUGUGUG............................................................................................... 1 1 hsa-mir-558_L03 ESC_DGCR8_454 .GUGUGUGUGUGUGUGUGUGUGUGU............................................................................................ 1 1 hsa-mir-558_L04 ESC_DGCR8_454 .GUGUGUGUGUGUGUGUGUGUGUGUG........................................................................................... 1 1 hsa-mir-558_L05 ESC_DGCR8_454 .GUGUGUGUGUGUGUGUGUGUGU.............................................................................................. 1 1 hsa-mir-558_L06 ESC_WT_454 hsa-mir-574 chr4:38546028-38546163 + GGCGCGGCCGAGGGACCUGCGUGGGUGCGGGCGUGUGAGUGUGUGUGUGUGAGUGUGUGUCGCUCCGGGUCCACGCUCAUGCACACACCCACACGCCCACACUCAGGGUCUGCCCCC ((.(.(((....((((((...((((((.(((((((((.(.(((((((((((((((((..((......))..))))))))))))))))))))))))))).)))))))))))))))))) (-72.70) ...................................UGAGUGUGUGUGUGUGAGUGUGU........................................................... 2 1 hsa-mir-574_L01_M ESC_WT_454 ........................................GUGUGUGUGUGAGUGUGU........................................................... 1 1 hsa-mir-574_L02 ESC_DGCR8_454 ...................................UGAGUGUGUGUGUGUGAGUGUGUG.......................................................... 1 1 hsa-mir-574_L03 ESC_WT_454 hsa-mir-592 chr7:126485358-126485494 - AAUUUGAUGAUAUUAUGCCAUGACAUUGUGUCAAUAUGCGAUGAUGUGUUGUGAUGGCACAGCGUCAUCACGUGGUGACGCAACAUCAUGACGUAAGACGUCACAACGCCAGUUAA ....(((((...(((((.(((((..((((((((.((((.((((((((..((((....)))))))))))).)))).))))))))..))))).)))))..)))))............. (-43.30) .........................UUGUGUCAAUAUGCGAUGAUGU..................................................................... 2 1 hsa-mir-592_L01_M ESC_WT_454 hsa-mir-652 chrX:109185193-109185330 + AGGGCCGCCACGAAUGGCUAUGCACUGCACAACCCUAGGAGAGGGUGCCAUUCACAUAGACUAUAAUUGAAUGGCGCCACUAGGGUUGUGCAGUGCACAACCUACACAACUGUACUC (((...((((....))))..((((((((((((((((((.....(((((((((((..((.....))..))))))))))).))))))))))))))))))...))).............. (-61.30) .....................................................................AAUGGCGCCACUAGGGUUGUG........................... 1 1 hsa-mir-652_R01_M ESC_WT_454 hsa-mir-653 chr7:92949988-92950123 - GAGGUUCUAAUUUUUCAUUCCUUCAGUGUUGAAACAAUCUCUACUGAACCAGCUUCAAACAAGUUCACUGGAGUUUGUUUCAAUAUUGCAAGAAUGAUAAGAUGGAAGCUACUUUCAU .((.(((((.(((.((((((...((((((((((((((.(((((.(((((.............))))).))))).))))))))))))))...)))))).))).))))).))........ (-40.92) ............................UUGAAACAAUCUCUACUGAACC.................................................................... 1 1 hsa-mir-653_L01_M ESC_WT_454 hsa-mir-668 chr14:100591328-100591433 + CACUCCCUUAAGGUAAGUGCGCCUCGGGUGAGCAUGCACUUAAUGUGGGUGUAUGUCACUCGGCUCGGCCCACUACCCAAUACUAUCC ...........((((.(((.(((((((((((.(((((((((.....)))))))))))))))))...))).)))))))........... (-34.00) .....................................................UGUCACUCGGCUCGGCCCACUACC........... 2 1 hsa-mir-668_R01_M ESC_DGCR8_454 hsa-mir-671 chr7:150566420-150566577 + GCCCGGCUGGCAGGUGAACUGGCAGGCCAGGAAGAGGAGGAAGCCCUGGAGGGGCUGGAGGUGAUGGAUGUUUUCCUCCGGUUCUCAGGGCUCCACCUCUUUCGGGCCGUAGAGCCAGGGCUGGUGCAGAAGUUCUC (((((((((.(((.....))).).((((.((((((((.(((.((((((..(((((((((((.(((....)))..)))))))))))))))))))).)))))))).))))....)))).))))................ (-75.10) .....................................AGGAAGCCCUGGAGGGGCUGGAGG............................................................................ 2 1 hsa-mir-671_L01_M ESC_WT_454 ......................................GGAAGCCCUGGAGGGGCUGGAG............................................................................. 1 1 hsa-mir-671_L02 ESC_WT_454 hsa-mir-7-1 chr9:85774463-85774612 - AGAAGAUUCAUUGGAUGUUGGCCUAGUUCUGUGUGGAAGACUAGUGAUUUUGUUGUUUUUAGAUAACUAAAUCGACAACAAAUCACAGUCUGCCAUAUGGCACAGGCCAUGCCUCUACAGGACAAAUGAU ......(((..((((.((((((((.((.((((((((.(((((.(((((((.(((((((((((....)))))..)))))))))))))))))).)))))))).)))))))).)).))))..)))........ (-48.60) .................................UGGAAGACUAGUGAUUUUGUUGUU......................................................................... 408 3 hsa-mir-7-1_L01_M ESC_WT_454 .................................UGGAAGACUAGUGAUUUUGUUGU.......................................................................... 188 3 hsa-mir-7-1_L02 ESC_WT_454 .................................UGGAAGACUAGUGAUUUUGUUG........................................................................... 141 3 hsa-mir-7-1_L03 ESC_WT_454 .................................UGGAAGACUAGUGAUUUUGUU............................................................................ 4 3 hsa-mir-7-1_L04 ESC_WT_454 .................................UGGAAGACUAGUGAUUUUGUUGUUU........................................................................ 3 1 hsa-mir-7-1_L05 ESC_WT_454 ......................................GACUAGUGAUUUUGUUGUU......................................................................... 3 3 hsa-mir-7-1_L06 ESC_WT_454 .................................UGGAAGACUAGUGAUUUUGUUGU.......................................................................... 2 3 hsa-mir-7-1_L07 ESC_DGCR8_454 .................................UGGAAGACUAGUGAUUUUGUUGUU......................................................................... 2 3 hsa-mir-7-1_L08 ESC_DGCR8_454 .................................UGGAAGACUAGUGAUUUUGU............................................................................. 2 3 hsa-mir-7-1_L09 ESC_WT_454 .................................UGGAAGACUAGUGAUUUUG.............................................................................. 1 3 hsa-mir-7-1_L10 ESC_WT_454 ..................................GGAAGACUAGUGAUUUUGUUGUU......................................................................... 1 3 hsa-mir-7-1_L11 ESC_WT_454 ...........................................................................CAACAAAUCACAGUCUGCCAUA................................. 3 1 hsa-mir-7-1_R01*_M ESC_WT_454 ...........................................................................CAACAAAUCACAGUCUGCCAU.................................. 3 1 hsa-mir-7-1_R02* ESC_WT_454 hsa-mir-7-2 chr15:86956040-86956189 + AGAACUGGCCUGGAUACAGAGUGGACCGGCUGGCCCCAUCUGGAAGACUAGUGAUUUUGUUGUUGUCUUACUGCGCUCAACAACAAAUCCCAGUCUACCUAAUGGUGCCAGCCAUCGCAGCGGGGUGCAGGAAAU ....(((((((.(.......((((...(((((((.((((..((.(((((.(.(((((.(((((((............))))))))))))).))))).))..)))).))))))).))))..).)))).)))..... (-51.90) ........................................UGGAAGACUAGUGAUUUUGUUGUU....................................................................... 408 3 hsa-mir-7-2_L01_M ESC_WT_454 ........................................UGGAAGACUAGUGAUUUUGUUGU........................................................................ 188 3 hsa-mir-7-2_L02 ESC_WT_454 ........................................UGGAAGACUAGUGAUUUUGUUG......................................................................... 141 3 hsa-mir-7-2_L03 ESC_WT_454 ........................................UGGAAGACUAGUGAUUUUGUUGUUG...................................................................... 8 1 hsa-mir-7-2_L04 ESC_WT_454 ........................................UGGAAGACUAGUGAUUUUGUU.......................................................................... 4 3 hsa-mir-7-2_L05 ESC_WT_454 .............................................GACUAGUGAUUUUGUUGUU....................................................................... 3 3 hsa-mir-7-2_L06 ESC_WT_454 ........................................UGGAAGACUAGUGAUUUUGUUGU........................................................................ 2 3 hsa-mir-7-2_L07 ESC_DGCR8_454 ........................................UGGAAGACUAGUGAUUUUGUUGUU....................................................................... 2 3 hsa-mir-7-2_L08 ESC_DGCR8_454 ........................................UGGAAGACUAGUGAUUUUGU........................................................................... 2 3 hsa-mir-7-2_L09 ESC_WT_454 ........................................UGGAAGACUAGUGAUUUUG............................................................................ 1 3 hsa-mir-7-2_L10 ESC_WT_454 .......................................CUGGAAGACUAGUGAUUUUGUUGU........................................................................ 1 1 hsa-mir-7-2_L11 ESC_WT_454 .........................................GGAAGACUAGUGAUUUUGUUGUU....................................................................... 1 3 hsa-mir-7-2_L12 ESC_WT_454 hsa-mir-7-3 chr19:4721662-4721811 + UGGUGAAGAAGAUUAGAGUGGCUGUGGUCUAGUGCUGUGUGGAAGACUAGUGAUUUUGUUGUUCUGAUGUACUACGACAACAAGUCACAGCCGGCCUCAUAGCGCAGACUCCCUUCGACCUUCGCCUUC .(((((((....(..(((.((....(((((.((((((((.((..(.((.(((((((.((((((.((......)).))))))))))))))).)..)).))))))))))))))))))..).)))))))... (-48.50) .......................................UGGAAGACUAGUGAUUUUGUUGUU.................................................................. 408 3 hsa-mir-7-3_L01_M ESC_WT_454 .......................................UGGAAGACUAGUGAUUUUGUUGU................................................................... 188 3 hsa-mir-7-3_L02 ESC_WT_454 .......................................UGGAAGACUAGUGAUUUUGUUG.................................................................... 141 3 hsa-mir-7-3_L03 ESC_WT_454 .......................................UGGAAGACUAGUGAUUUUGUU..................................................................... 4 3 hsa-mir-7-3_L04 ESC_WT_454 ............................................GACUAGUGAUUUUGUUGUU.................................................................. 3 3 hsa-mir-7-3_L05 ESC_WT_454 .......................................UGGAAGACUAGUGAUUUUGUUGU................................................................... 2 3 hsa-mir-7-3_L06 ESC_DGCR8_454 .......................................UGGAAGACUAGUGAUUUUGUUGUU.................................................................. 2 3 hsa-mir-7-3_L07 ESC_DGCR8_454 .......................................UGGAAGACUAGUGAUUUUGU...................................................................... 2 3 hsa-mir-7-3_L08 ESC_WT_454 .......................................UGGAAGACUAGUGAUUUUG....................................................................... 1 3 hsa-mir-7-3_L09 ESC_WT_454 ........................................GGAAGACUAGUGAUUUUGUUGUU.................................................................. 1 3 hsa-mir-7-3_L10 ESC_WT_454 hsa-mir-708 chr11:78790694-78790821 - GUGAAAUGGUAACUGCCCUCAAGGAGCUUACAAUCUAGCUGGGGGUAAAUGACUUGCACAUGAACACAACUAGACUGUGAGCUUCUAGAGGGCAGGGACCUUACCCU ((((...(((..((((((((.(((((((((((.(((((.((...((..(((.......)))..)).)).))))).))))))))))).))))))))..)))))))... (-50.30) ....................AAGGAGCUUACAAUCUAGCUGGG................................................................ 203 1 hsa-mir-708_L01_M ESC_WT_454 .....................AGGAGCUUACAAUCUAGCUGGG................................................................ 13 1 hsa-mir-708_L02 ESC_WT_454 ....................AAGGAGCUUACAAUCUAGCUGG................................................................. 10 1 hsa-mir-708_L03 ESC_WT_454 ...................CAAGGAGCUUACAAUCUAGCUGGG................................................................ 5 1 hsa-mir-708_L04 ESC_WT_454 ......................GGAGCUUACAAUCUAGCUGGG................................................................ 2 1 hsa-mir-708_L05 ESC_WT_454 ....................AAGGAGCUUACAAUCUAGCUG.................................................................. 2 1 hsa-mir-708_L06 ESC_WT_454 ....................AAGGAGCUUACAAUCUAGCUGG................................................................. 1 1 hsa-mir-708_L07 ESC_DGCR8_454 ....................AAGGAGCUUACAAUCUAGCUGGG................................................................ 1 1 hsa-mir-708_L08 ESC_DGCR8_454 ........................AGCUUACAAUCUAGCUGGG................................................................ 1 1 hsa-mir-708_L09 ESC_WT_454 ...................................................................AACUAGACUGUGAGCUUCUAGA.................. 1 1 hsa-mir-708_R01*_M ESC_WT_454 ..................................................................CAACUAGACUGUGAGCUUCUAGA.................. 1 1 hsa-mir-708_R02* ESC_WT_454 hsa-mir-720 chr3:165541803-165541952 + GGAGCGAGACCGGAUCUCACACGGUGGUGUUAAUAUCUCGCUGGGGCCUCCAAAAUGUUGUGCCCAGGGGUGUUAGAGAAAACACCACACUUUGAGAUGAAUUAAGAGUCCUUUAUUAGCCGGCGACCG ((..((...((((.(((((....((((((((((((((((....(((((..(.....)..).)))).)))))))))......)))))))....)))))..(((.(((....))).)))..)))))).)). (-39.50) ..................................AUCUCGCUGGGGCCUCCA............................................................................. 2 1 hsa-mir-720_L01_M ESC_DGCR8_454 ...................................UCUCGCUGGGGCCUCCAA............................................................................ 1 1 hsa-mir-720_L02 ESC_DGCR8_454 hsa-mir-744 chr17:11925921-11926058 + CACACUGGGUUGGGCAAGGUGCGGGGCUAGGGCUAACAGCAGUCUUACUGAAGGUUUCCUGGAAACCACGCACAUGCUGUUGCCACUAACCUCAACCUUACUCGGUCCUGACCGGCU ......((..((((.(((((..((((.((((((.(((((((.((.....)).((((((...)))))).......)))))))))).))).)))).))))).))))..))......... (-44.90) ...................UGCGGGGCUAGGGCUAACAGCA............................................................................ 15 1 hsa-mir-744_L01_M ESC_WT_454 ...................UGCGGGGCUAGGGCUAACAGC............................................................................. 5 1 hsa-mir-744_L02 ESC_WT_454 ...................UGCGGGGCUAGGGCUAACA............................................................................... 1 1 hsa-mir-744_L03 ESC_WT_454 ...................UGCGGGGCUAGGGCUAAC................................................................................ 1 1 hsa-mir-744_L04 ESC_WT_454 hsa-mir-758 chr14:100562090-100562217 + UCAGCACGUGCCUGGAUACAUGAGAUGGUUGACCAGAGAGCACACGCUUUAUUUGUGCCGUUUGUGACCUGGUCCACUAACCCUCAGUAUCUAAUGCCCCCUUGGAG ((((...(.((.(((((((.((((.((((.((((((...(((.((((.........).))).)))...)))))).))))...)))))))))))..)))...)))).. (-30.70) .........................UGGUUGACCAGAGAGCACACG............................................................. 4 1 hsa-mir-758_L01*_M ESC_WT_454 ............................................................UUUGUGACCUGGUCCACUAACC......................... 37 1 hsa-mir-758_R01_M ESC_WT_454 ............................................................UUUGUGACCUGGUCCACUAACCC........................ 27 1 hsa-mir-758_R02 ESC_WT_454 .............................................................UUGUGACCUGGUCCACUAACC......................... 15 1 hsa-mir-758_R03 ESC_WT_454 ............................................................UUUGUGACCUGGUCCACUAAC.......................... 14 1 hsa-mir-758_R04 ESC_WT_454 ............................................................UUUGUGACCUGGUCCACUAACCCU....................... 9 1 hsa-mir-758_R05 ESC_WT_454 ............................................................UUUGUGACCUGGUCCACUAA........................... 1 1 hsa-mir-758_R06 ESC_WT_454 .............................................................UUGUGACCUGGUCCACUAAC.......................... 1 1 hsa-mir-758_R07 ESC_WT_454 .............................................................UUGUGACCUGGUCCACUAACCC........................ 1 1 hsa-mir-758_R08 ESC_WT_454 hsa-mir-877 chr6:30660068-30660193 + UGCUGAGAGGCUAGAGAAGGUAGAGGAGAUGGCGCAGGGGACACGGGCAAAGACUUGGGGGUUCCUGGGACCCUCAGACGUGUGUCCUCUUCUCCCUCCUCCCAGGUGUAUGAGGAAUUGCGGGC .(((....))).......((..((((((..((.(.((((((((((.(.......(((((((((.....))))))))).).)))))))))).).))))))))))...((((........))))... (-46.20) ...................GUAGAGGAGAUGGCGCAGGGG..................................................................................... 17 1 hsa-mir-877_L01_M ESC_DGCR8_454 ...................GUAGAGGAGAUGGCGCAGGGGAC................................................................................... 14 1 hsa-mir-877_L02 ESC_DGCR8_454 ...................GUAGAGGAGAUGGCGCAGGGGA.................................................................................... 11 1 hsa-mir-877_L03 ESC_DGCR8_454 ...................GUAGAGGAGAUGGCGCAGGGGACA.................................................................................. 8 1 hsa-mir-877_L04 ESC_DGCR8_454 ...................GUAGAGGAGAUGGCGCAGGG...................................................................................... 6 1 hsa-mir-877_L05 ESC_DGCR8_454 ....................UAGAGGAGAUGGCGCAGGGGAC................................................................................... 3 1 hsa-mir-877_L06 ESC_DGCR8_454 ...................GUAGAGGAGAUGGCGCAGGGGACAC................................................................................. 1 1 hsa-mir-877_L07 ESC_DGCR8_454 ....................UAGAGGAGAUGGCGCAGGGGACAC................................................................................. 1 1 hsa-mir-877_L08 ESC_DGCR8_454 ...................GUAGAGGAGAUGGCGCAGGGGACA.................................................................................. 1 1 hsa-mir-877_L09 ESC_WT_454 ...................GUAGAGGAGAUGGCGCAGGGGA.................................................................................... 1 1 hsa-mir-877_L10 ESC_WT_454 ...................GUAGAGGAGAUGGCGCAGGGG..................................................................................... 1 1 hsa-mir-877_L11 ESC_WT_454 ..................................................................................UGUCCUCUUCUCCCUCCUCCCAG.................... 1 1 hsa-mir-877_R01*_M ESC_DGCR8_454 ..................................................................................UGUCCUCUUCUCCCUCCUCCCA..................... 1 1 hsa-mir-877_R02* ESC_DGCR8_454 ..................................................................................UGUCCUCUUCUCCCUCCUCCCA..................... 1 1 hsa-mir-877_R03* ESC_WT_454 hsa-mir-9-1 chr1:154656737-154656865 - AGCCAGGAGGCGGGGUUGGUUGUUAUCUUUGGUUAUCUAGCUGUAUGAGUGGUGUGGAGUCUUCAUAAAGCUAGAUAACCGAAAGUAAAAAUAACCCCAUACACUGCG .(((....)))(((((((....(((..(((((((((((((((.((((((.((.......)))))))).)))))))))))))))..)))...))))))).......... (-44.50) .........................UCUUUGGUUAUCUAGCUGUAUGA............................................................ 4 3 hsa-mir-9-1_L01_M ESC_WT_454 .........................UCUUUGGUUAUCUAGCUGUAUG............................................................. 1 3 hsa-mir-9-1_L02 ESC_WT_454 hsa-mir-9-2 chr5:87998407-87998533 - GGCCUGUGUGGGAAGCGAGUUGUUAUCUUUGGUUAUCUAGCUGUAUGAGUGUAUUGGUCUUCAUAAAGCUAGAUAACCGAAAGUAAAAACUCCUUCAAGAUCGCCG (((..((.(..((((.(((((.(((..(((((((((((((((.((((((..(....)..)))))).)))))))))))))))..))).))))))))).).)).))). (-44.40) .........................UCUUUGGUUAUCUAGCUGUAUGA.......................................................... 4 3 hsa-mir-9-2_L01_M ESC_WT_454 .........................UCUUUGGUUAUCUAGCUGUAUG........................................................... 1 3 hsa-mir-9-2_L02 ESC_WT_454 hsa-mir-9-3 chr15:87712232-87712361 + CUGGCUAAGGGAGGCCCGUUUCUCUCUUUGGUUAUCUAGCUGUAUGAGUGCCACAGAGCCGUCAUAAAGCUAGAUAACCGAAAGUAGAAAUGAUUCUCACAACUUCUGC ...((.(((.((((..(((((((((.(((((((((((((((.(((((..((......))..))))).))))))))))))))))).)))))))..))))....)))..)) (-42.60) ........................UCUUUGGUUAUCUAGCUGUAUGA.............................................................. 4 3 hsa-mir-9-3_L01_M ESC_WT_454 ........................UCUUUGGUUAUCUAGCUGUAUG............................................................... 1 3 hsa-mir-9-3_L02 ESC_WT_454 hsa-mir-923 chr17:30502272-30502366 - AAUUUAAGCAUAUUUGUCAGCGGAGGAAAAGAAACUAACCAGGAUUCCCUCAGUAAUGGCGAGUGAACAGGGAA ..........(((((((((((.((((....(((.((.....)).))))))).))..)))))))))......... (-14.10) ...................GCGGAGGAAAAGAAACUAACCA................................. 1 1 hsa-mir-923_L01_M ESC_DGCR8_454 ....................CGGAGGAAAAGAAACUAACCA................................. 1 1 hsa-mir-923_L02 ESC_WT_454 ...................GCGGAGGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_L03 ESC_WT_454 ....................CGGAGGAAAAGAAACUAACCAG................................ 1 1 hsa-mir-923_L04 ESC_WT_454 ...................................UAACCAGGAUUCCCUCAG..................... 6 1 hsa-mir-923_O01 ESC_DGCR8_454 ..................................CUAACCAGGAUUCCCUCA...................... 6 1 hsa-mir-923_O02 ESC_DGCR8_454 ..................................CUAACCAGGAUUCCCUCAG..................... 5 1 hsa-mir-923_O03 ESC_DGCR8_454 ...................................UAACCAGGAUUCCCUCAG..................... 4 1 hsa-mir-923_O04 ESC_WT_454 .................................ACUAACCAGGAUUCCCUCAG..................... 2 1 hsa-mir-923_O05 ESC_DGCR8_454 .........................GAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_O06 ESC_DGCR8_454 .................................ACUAACCAGGAUUCCCUCA...................... 1 1 hsa-mir-923_O07 ESC_DGCR8_454 ........................GGAAAAGAAACUAACCAGGA.............................. 1 1 hsa-mir-923_O08 ESC_DGCR8_454 ..................................CUAACCAGGAUUCCCUCA...................... 1 1 hsa-mir-923_O09 ESC_WT_454 ..................................CUAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O10 ESC_WT_454 hsa-mir-92a-1 chr13:90801549-90801666 + CUCAAACCCCUUUCUACACAGGUUGGGAUCGGUUGCAAUGCUGUGUUUCUGUAUGGUAUUGCACUUGUCCCGGCCUGUUGAGUUUGGUGGGGAUUGU ..(((.((((...((..((((((((((((.(((.(((((((((((......)))))))))))))).))))))))))))..))......)))).))). (-45.00) ........................................................UAUUGCACUUGUCCCGGCCUGU................... 535 2 hsa-mir-92a-1_R01_M ESC_WT_454 ........................................................UAUUGCACUUGUCCCGGCCUG.................... 57 2 hsa-mir-92a-1_R02 ESC_WT_454 ........................................................UAUUGCACUUGUCCCGGCCU..................... 17 2 hsa-mir-92a-1_R03 ESC_WT_454 ........................................................UAUUGCACUUGUCCCGGCCUGUU.................. 11 1 hsa-mir-92a-1_R04 ESC_WT_454 ........................................................UAUUGCACUUGUCCCGGC....................... 7 2 hsa-mir-92a-1_R05 ESC_WT_454 ........................................................UAUUGCACUUGUCCCGGCCUGU................... 6 2 hsa-mir-92a-1_R06 ESC_DGCR8_454 ........................................................UAUUGCACUUGUCCCGGCC...................... 4 2 hsa-mir-92a-1_R07 ESC_WT_454 .........................................................AUUGCACUUGUCCCGGCCUGU................... 3 2 hsa-mir-92a-1_R08 ESC_WT_454 ........................................................UAUUGCACUUGUCCCGGCCU..................... 2 2 hsa-mir-92a-1_R09 ESC_DGCR8_454 ........................................................UAUUGCACUUGUCCCGGCCUGUU.................. 1 1 hsa-mir-92a-1_R10 ESC_DGCR8_454 .........................................................AUUGCACUUGUCCCGGCCUG.................... 1 2 hsa-mir-92a-1_R11 ESC_WT_454 ...........................................................UGCACUUGUCCCGGCCUGU................... 1 2 hsa-mir-92a-1_R12 ESC_WT_454 hsa-mir-92a-2 chrX:133131214-133131328 - UCAUGCCCAUUCAUCCCUGGGUGGGGAUUUGUUGCAUUACUUGUGUUCUAUAUAAAGUAUUGCACUUGUCCCGGCCUGUGGAAGAAAGGAGGAU ......((.(((.(((.(((((.(((((..((.(((.(((((((((...)))).))))).)))))..))))).))))).))).))).))..... (-35.20) .........................................................UAUUGCACUUGUCCCGGCCUGU............... 535 2 hsa-mir-92a-2_R01_M ESC_WT_454 .........................................................UAUUGCACUUGUCCCGGCCUG................ 57 2 hsa-mir-92a-2_R02 ESC_WT_454 .........................................................UAUUGCACUUGUCCCGGCCU................. 17 2 hsa-mir-92a-2_R03 ESC_WT_454 .........................................................UAUUGCACUUGUCCCGGC................... 7 2 hsa-mir-92a-2_R04 ESC_WT_454 .........................................................UAUUGCACUUGUCCCGGCCUGU............... 6 2 hsa-mir-92a-2_R05 ESC_DGCR8_454 .........................................................UAUUGCACUUGUCCCGGCC.................. 4 2 hsa-mir-92a-2_R06 ESC_WT_454 ..........................................................AUUGCACUUGUCCCGGCCUGU............... 3 2 hsa-mir-92a-2_R07 ESC_WT_454 .........................................................UAUUGCACUUGUCCCGGCCU................. 2 2 hsa-mir-92a-2_R08 ESC_DGCR8_454 .........................................................UAUUGCACUUGUCCCGGCCUGUG.............. 1 1 hsa-mir-92a-2_R09 ESC_WT_454 ............................................................UGCACUUGUCCCGGCCUGU............... 1 2 hsa-mir-92a-2_R10 ESC_WT_454 ..........................................................AUUGCACUUGUCCCGGCCUG................ 1 2 hsa-mir-92a-2_R11 ESC_WT_454 hsa-mir-92b chr1:153431572-153431707 + AGCGGGAUCCCGGGCCCCGGGCGGGCGGGAGGGACGGGACGCGGUGCAGUGUUGUUUUUUCCCCCGCCAAUAUUGCACUCGUCCCGGCCUCCGGCCCCCCCGGCCCCCCGGCCUCC ....(((..(((((..(((((.((((.(((((..(((((((.((((((((((((.............))))))))))))))))))).))))).)))).)))))...)))))..))) (-74.82) ......................................................................UAUUGCACUCGUCCCGGCCUCC........................ 11 1 hsa-mir-92b_R01_M ESC_WT_454 ......................................................................UAUUGCACUCGUCCCGGCCUC......................... 4 1 hsa-mir-92b_R02 ESC_WT_454 hsa-mir-93 chr7:99529307-99529426 - GACCUCAGUCCUGGGGGCUCCAAAGUGCUGUUCGUGCAGGUAGUGUGAUUACCCAACCUACUGCUGAGCUAGCACUUCCCGAGCCCCCGGGACACGUUC .......(((((((((((((..((((((((((((.((((.(((..((......))..)))))))))))).)))))))...)))))))))))))...... (-54.60) ....................CAAAGUGCUGUUCGUGCAGGUAG........................................................ 377 1 hsa-mir-93_L01_M ESC_WT_454 ....................CAAAGUGCUGUUCGUGCAGGUA......................................................... 81 1 hsa-mir-93_L02 ESC_WT_454 ....................CAAAGUGCUGUUCGUGCAGGU.......................................................... 44 1 hsa-mir-93_L03 ESC_WT_454 ....................CAAAGUGCUGUUCGUGCAGGUAGU....................................................... 16 1 hsa-mir-93_L04 ESC_WT_454 ....................CAAAGUGCUGUUCGUGCAGG........................................................... 10 1 hsa-mir-93_L05 ESC_WT_454 ....................CAAAGUGCUGUUCGUGCAGGUAG........................................................ 4 1 hsa-mir-93_L06 ESC_DGCR8_454 ....................CAAAGUGCUGUUCGUGCAGGUA......................................................... 3 1 hsa-mir-93_L07 ESC_DGCR8_454 ....................CAAAGUGCUGUUCGUGCAG............................................................ 2 1 hsa-mir-93_L08 ESC_WT_454 ...................CCAAAGUGCUGUUCGUGCAGGUAG........................................................ 1 1 hsa-mir-93_L09 ESC_WT_454 ...........................................................ACUGCUGAGCUAGCACUUCCCG.................. 1 1 hsa-mir-93_R01*_M ESC_WT_454 hsa-mir-935 chr19:59177353-59177483 + CUCAAGGCCGGCGGGGGCGCGGGCGGCAGUGGCGGGAGCGGCCCCUCGGCCAUCCUCCGUCUGCCCAGUUACCGCUUCCGCUACCGCCGCCGCUCCCGCUCUAGCUCCCG .....(((.(((((((((...((((((.(((((((((((((...((.(((............))).))...))))))))))))).)))))))))))))))...))).... (-63.90) .................................................................CAGUUACCGCUUCCGCUACCGC....................... 3 1 hsa-mir-935_R01_M ESC_WT_454 ................................................................CCAGUUACCGCUUCCGCUACCGC....................... 3 1 hsa-mir-935_R02 ESC_WT_454 hsa-mir-96 chr7:129201748-129201865 - GCCAUCUGCUUGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAAAGCAGGACC ....(((((((..((.((.((((((((.((((((..(((((((((......)))...))))))..)))))))))))))).)).))..)))))))... (-46.10) ..................UUUGGCACUAGCACAUUUUUGCU........................................................ 288 1 hsa-mir-96_L01_M ESC_WT_454 ..................UUUGGCACUAGCACAUUUUUGC......................................................... 11 1 hsa-mir-96_L02 ESC_WT_454 ...................UUGGCACUAGCACAUUUUUGCU........................................................ 6 1 hsa-mir-96_L03 ESC_WT_454 ..................UUUGGCACUAGCACAUUUUUG.......................................................... 5 1 hsa-mir-96_L04 ESC_WT_454 ..................UUUGGCACUAGCACAUUUUUGCUU....................................................... 4 1 hsa-mir-96_L05 ESC_WT_454 ..................UUUGGCACUAGCACAUUUUUGCU........................................................ 2 1 hsa-mir-96_L06 ESC_DGCR8_454 .......................CACUAGCACAUUUUUGCU........................................................ 1 1 hsa-mir-96_L07 ESC_WT_454 hsa-mir-99b chr19:56887657-56887766 + CUGGGUCCUGGCACCCACCCGUAGAACCGACCUUGCGGGGCCUUCGCCGCACACAAGCUCGUGUCUGUGGGUCCGUGUCGGGGGCUCAC .(((((((((((((..(((((((((..(((.((((.(((((....))).).).)))).)))..)))))))))..))))).)))))))). (-42.80) ...............CACCCGUAGAACCGACCUUGCG.................................................... 38 1 hsa-mir-99b_L01_M ESC_WT_454 ...............CACCCGUAGAACCGACCUUGC..................................................... 11 1 hsa-mir-99b_L02 ESC_WT_454 ...............CACCCGUAGAACCGACCUUGCG.................................................... 6 1 hsa-mir-99b_L03 ESC_DGCR8_454 ..............CCACCCGUAGAACCGACCUUGC..................................................... 2 1 hsa-mir-99b_L04 ESC_WT_454 ..............CCACCCGUAGAACCGACCUUGCG.................................................... 1 1 hsa-mir-99b_L05 ESC_WT_454 .....................................................CAAGCUCGUGUCUGUGGGUCCG.............. 8 1 hsa-mir-99b_R01*_M ESC_WT_454 .....................................................CAAGCUCGUGUCUGUGGGUCCGU............. 2 1 hsa-mir-99b_R02* ESC_WT_454 .....................................................CAAGCUCGUGUCUGUGGGUCC............... 1 1 hsa-mir-99b_R03* ESC_WT_454 .....................................................CAAGCUCGUGUCUGUGGGUC................ 1 1 hsa-mir-99b_R04* ESC_WT_454 .....................................................CAAGCUCGUGUCUGUGGGU................. 1 1 hsa-mir-99b_R05* ESC_WT_454