hsa-let-7d chr9:95980917-95981043 + AAAAAAAUGGGUUCCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGGGCCUUAUUAU .....((((((..(((((((.((((((((((((((.((((((...((((((.....)))))).(.....)..)))))).)))))))))))))))))))))..)))))).. (-50.20) ............................................................................AUACGACCUGCUGCCUUUC............... 1 1 hsa-let-7d_R01_M ES_Dicer-DEL hsa-mir-15b chr3:161605050-161605187 + AAUCCUACAUUUUUGAGGCCUUAAAGUACUGUAGCAGCACAUCAUGGUUUACAUGCUACAGUCAAGAUGCGAAUCAUUAUUUGCUGCUCUAGAAAUUUAAGGAAAUUCAUUCAAAACUAU .............((((.(((((((...(((.(((((((.((.((((((..(((.((.......)))))..)))))).)).))))))).)))...)))))))...))))........... (-32.70) ...............................UAGCAGCACAUCAUGGUUUACA................................................................... 11 1 hsa-mir-15b_L01_M ES_Dicer-DEL ..................................CAGCACAUCAUGGUUUACA................................................................... 1 1 hsa-mir-15b_L02 ES_Dicer-DEL hsa-mir-16-1 chr13:49521090-49521218 - UGAUAGCAAUGUCAGCAGUGCCUUAGCAGCACGUAAAUAUUGGCGUUAAGAUUCUAAAAUUAUCUCCAGUAUUAACUGUGCUGCUGAAGUAAGGUUGACCAUACUCUACAGUU ..........((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..)))))).............. (-38.50) .......................UAGCAGCACGUAAAUAUUGGCG.................................................................... 7 2 hsa-mir-16-1_L01_M ES_Dicer-DEL hsa-mir-16-2 chr3:161605207-161605327 + UGACAUACUUGUUCCACUCUAGCAGCACGUAAAUAUUGGCGUAGUGAAAUAUAUAUUAAACACCAAUAUUACUGUGCUGCUUUAGUGUGACAGGGAUACAG .......(((((..((((..(((((((((..((((((((.((..(((........))).)).))))))))..)))))))))..))))..)))))....... (-37.40) ...................UAGCAGCACGUAAAUAUUGGCG............................................................ 7 2 hsa-mir-16-2_L01_M ES_Dicer-DEL hsa-mir-19b-1 chr13:90801427-90801553 + GUUACUGAACACUGUUCUAUGGUUAGUUUUGCAGGUUUGCAUCCAGCUGUGUGAUAUUCUGCUGUGCAAAUCCAUGCAAAACUGACUGUGGUAGUGAAAAGUCUGU ...(((...(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))...))).... (-40.92) ..............................................................UGUGCAAAUCCAUGCAAAAC........................ 2 2 hsa-mir-19b-1_R01_M ES_Dicer-DEL hsa-mir-19b-2 chrX:133131347-133131482 - GAUGGAGAGAAUAUUCAAAGACAUUGCUACUUACAAUUAGUUUUGCAGGUUUGCAUUUCAGCGUAUAUAUGUAUAUGUGGCUGUGCAAAUCCAUGCAAAACUGAUUGUGAUAAUGUGUGCUUCCU ...((((.((....))..(.((((((....((((((((((((((((((((((((((....(((((((....)))))))....))))))).)).))))))))))))))))))))))).)..)))). (-44.10) .................................................................................UGUGCAAAUCCAUGCAAAAC........................ 2 2 hsa-mir-19b-2_R01_M ES_Dicer-DEL hsa-mir-20a chr13:90801300-90801410 + GACAGCUUCUGUAGCACUAAAGUGCUUAUAGUGCAGGUAGUGUUUAGUUAUCUACUGCAUUAUGAGCACUUAAAGUACUGCUAGCUGUAGA .((((((...((((.(((.(((((((((((((((((.(((((......)).))))))))))))))))))))..))).)))).))))))... (-41.50) .................UAAAGUGCUUAUAGUGCAGGUAG................................................... 1 1 hsa-mir-20a_L01_M ES_Dicer-DEL hsa-mir-21 chr17:55273389-55273500 + GUACCACCUUGUCGGGUAGCUUAUCAGACUGAUGUUGACUGUUGAAUCUCAUGGCAACACCAGUCGAUGGGCUGUCUGACAUUUUGGUAUC ((((((...((((((..((((((((.(((((.(((((.((((.(.....)))))))))).)))))))))))))..))))))...)))))). (-43.40) ................UAGCUUAUCAGACUGAUGUUGACU................................................... 15 1 hsa-mir-21_L01_M ES_Dicer-DEL hsa-mir-23a chr19:13808381-13808493 - CCUGUGCCACGGCCGGCUGGGGUUCCUGGGGAUGGGAUUUGCUUCCUGUCACAAAUCACAUUGCCAGGGAUUUCCAACCGACCCUGAGCUCUGCC ...(.((((.((.(((.((((((((((((.((((.((((((..........)))))).)))).))))))).))))).))).)).)).)).).... (-38.60) ......................................................AUCACAUUGCCAGGGAUUU...................... 1 1 hsa-mir-23a_R01_M ES_Dicer-DEL hsa-mir-25 chr7:99529099-99529222 - CUCCGGGACUGGCCAGUGUUGAGAGGCGGAGACUUGGGCAAUUGCUGGACGCUGCCCUGGGCAUUGCACUUGUCUCGGUCUGACAGUGCCGGCCCAACACUGC ....(((.(((((.(.((((...((((.(((((..(.(((((.(((((.......))..)))))))).)..))))).)))))))).)))))))))........ (-42.00) ..CCGGGACUGGCCAGUGUUGA................................................................................. 1 1 hsa-mir-25_L01_M ES_Dicer-DEL hsa-mir-30a chr6:72169955-72170065 - UUGACAGUGAGCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGCCUACUGCCU ....(((((.(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).))).)))))... (-44.50) ...............UGUAAACAUCCUCGACUGGAA...................................................... 4 1 hsa-mir-30a_L01_M ES_Dicer-DEL hsa-mir-30b chr8:135881925-135882052 - AGUCCUGCUUUAAACCAAGUUUCAGUUCAUGUAAACAUCCUACACUCAGCUGUAAUACAUGGAUUGGCUGGGAGGUGGAUGUUUACUUCAGCUGACUUGGAAUGUCAACCAAU ..............(((((..((((((...((((((((((.((.((((((((............))))))))..))))))))))))...)))))))))))............. (-37.60) .............................UGUAAACAUCCUACACUCAGCU.............................................................. 1 1 hsa-mir-30b_L01_M ES_Dicer-DEL hsa-mir-30c-1 chr1:40995523-40995651 + UGGGCUAUAACCAUGCUGUAGUGUGUGUAAACAUCCUACACUCUCAGCUGUGAGCUCAAGGUGGCUGGGAGAGGGUUGUUUACUCCUUCUGCCAUGGAAAACAUCAGC ((((((...((...((((.((.(((((.........))))).)))))).)).))))))..(((((.(((((.((((.....))))))))))))))............. (-35.70) .........................UGUAAACAUCCUACACUCUCAGCUGU......................................................... 1 2 hsa-mir-30c-1_L01_M ES_Dicer-DEL hsa-mir-30c-2 chr6:72143364-72143475 - ACUGAGCGACAGAUACUGUAAACAUCCUACACUCUCAGCUGUGGAAAGUAAGAAAGCUGGGAGAAGGCUGUUUACUCUUUCUGCCUUGGAA .(..((.(.((((....(((((((.(((...(((((((((..............))))))))).))).)))))))....)))))))..).. (-34.14) ................UGUAAACAUCCUACACUCUCAGCUGU................................................. 1 2 hsa-mir-30c-2_L01_M ES_Dicer-DEL hsa-mir-34a chr1:9134294-9134443 - GCCGUGGACCGGCCAGCUGUGAGUGUUUCUUUGGCAGUGUCUUAGCUGGUUGUUGUGAGCAAUAGUAAGGAAGCAAUCAGCAAGUAUACUGCCCUAGAAGUGCUGCACGUUGUGGGGCCCAAGAGGGAAGAUG .((.(((.((.((.(((.(((((..(((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..)))))..)).)))))))).))..)))...))....... (-55.70) ...............................UGGCAGUGUCUUAGCUGGUUGUUGU............................................................................. 1 1 hsa-mir-34a_L01_M ES_Dicer-DEL hsa-mir-96 chr7:129201748-129201865 - GCCAUCUGCUUGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAAAGCAGGACC ....(((((((..((.((.((((((((.((((((..(((((((((......)))...))))))..)))))))))))))).)).))..)))))))... (-46.10) ..................UUUGGCACUAGCACAUUUUU........................................................... 1 1 hsa-mir-96_L01_M ES_Dicer-DEL hsa-mir-101-1 chr1:65296685-65296799 - ACUGACAGGCUGCCCUGGCUCAGUUAUCACAGUGCUGAUGCUGUCUAUUCUAAAGGUACAGUACUGUGAUAACUGAAGGAUGGCAGCCAUCUUA .......(((((((.....((((((((((((((((((.((((............)))))))))))))))))))))).....)))))))...... (-47.30) ...................UCAGUUAUCACAGUGCUGAUGCU.................................................... 1 1 hsa-mir-101-1_L01_M ES_Dicer-DEL hsa-mir-106a chrX:133131874-133131994 - CAGGAAUAGGCCUUGGCCAUGUAAAAGUGCUUACAGUGCAGGUAGCUUUUUGAGAUCUACUGCAAUGUAAGCACUUCUUACAUUACCAUGGUGAUUUAGU ...((((..(((.(((..(((((((((((((((((.(((((.(((.((.....)).)))))))).))))))))))).))))))..))).))).))))... (-38.80) ..........................GUGCUUACAGUGCAGGUAGC...................................................... 1 1 hsa-mir-106a_L01_M ES_Dicer-DEL hsa-mir-106b chr7:99529532-99529653 - UCCCCACCUCCCGCUCCAGCCCUGCCGGGGCUAAAGUGCUGACAGUGCAGAUAGUGGUCCUCUCCGUGCUACCGCACUGUGGGUACUUGCUGCUCCAGCAGGGCACGCACAGCGUCCGUGG ...((((....((((...(((((((.(((((..(((((((.(((((((.(.((((((......))..))))).))))))).)))))))...))))).)))))))......))))...)))) (-60.10) ...............................UAAAGUGCUGACAGUGCAG....................................................................... 3 1 hsa-mir-106b_L01_M ES_Dicer-DEL hsa-mir-122 chr18:54269266-54269390 + ACAGAGUUUCCUUAGCAGAGCUGUGGAGUGUGACAAUGGUGUUUGUGUCUAAACUAUCAAACGCCAUUAUCACACUAAAUAGCUACUGCUAGGCAAUCCUUCCC ..((..((.(((.(((((((((((..(((((((.(((((((((((.((....))...))))))))))).)))))))..)))))).)))))))).))..)).... (-47.20) .......................UGGAGUGUGACAAUGGUGU.............................................................. 2 1 hsa-mir-122_L01_M ES_Dicer-DEL hsa-mir-127 chr14:100419049-100419185 + AGGUCUCGCUGUGAUCACUGUCUCCAGCCUGCUGAAGCUCAGAGGGCUCUGAUUCAGAAAGAUCAUCGGAUCCGUCUGAGCUUGGCUGGUCGGAAGUCUCAUCAUCUGCUUCCUUC .((((.......)))).......((((((.....(((((((((.((.((((((((.....))..)))))).)).)))))))))))))))..((((((..........))))))... (-44.50) .................................................................UCGGAUCCGUCUGAGCUUGG............................... 1 1 hsa-mir-127_R01_M ES_Dicer-DEL hsa-mir-136 chr14:100420772-100420893 + GGUGUUGGAUGAGCCCUCGGAGGACUCCAUUUGUUUUGAUGAUGGAUUCUUAUGCUCCAUCAUCGUCUCAAAUGAGUCUUCAGAGGGUUCUAUCAUUUCGU .......(((((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).)))....... (-48.10) ..UGUUGGAUGAGCCCUCGGA................................................................................ 1 1 hsa-mir-136_L01_M ES_Dicer-DEL .GUGUUGGAUGAGCCCUCGGA................................................................................ 1 1 hsa-mir-136_L02 ES_Dicer-DEL hsa-mir-140 chr16:68524465-68524604 + CCGCGCCCUGUGUGUGUCUCUCUCUGUGUCCUGCCAGUGGUUUUACCCUAUGGUAGGUUACGUCAUGCUGUUCUACCACAGGGUAGAACCACGGACAGGAUACCGGGGCACCCUCUGCGUCG ..((((...(.(.(((((((.....((((((((((.(((((((((((((.(((((((..(((......)))))))))).))))))))))))))).)))))))).))))))).).).)))).. (-60.20) .......................................................................UCUACCACAGGGUAGAACCACGGAC.......................... 1 1 hsa-mir-140_R01_M ES_Dicer-DEL hsa-mir-142 chr17:53763572-53763698 - CGGACAGACAGACAGUGCAGUCACCCAUAAAGUAGAAAGCACUACUAACAGCACUGGAGGGUGUAGUGUUUCCUACUUUAUGGAUGAGUGUACUGUGGGCUUCGGA (.((.((.(..((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).))))))))..))))).). (-47.40) ..........................AUAAAGUAGAAAGCACUACU............................................................ 1 1 hsa-mir-142_L01_M ES_Dicer-DEL ...........................UAAAGUAGAAAGCACUACUAA.......................................................... 1 1 hsa-mir-142_L02 ES_Dicer-DEL hsa-mir-181d chr19:13846669-13846845 + CCUGGGCACGUCCCCUCCCCUAGGCCACAGCCGAGGUCACAAUCAACAUUCAUUGUUGUCGGUGGGUUGUGAGGACUGAGGCCAGACCCACCGGGGGAUGAAUGUCACUGUGGCUGGGCCAGACACGGCUUAAGGGGAAUGGGGACUGGGGACAGG ((((..(..(((((((((((((((((...(((..(((((((....(((((((((.(..((((((((((....((.(....))).))))))))))).)))))))))...))))))).))).......))))).))))))..))))))...)..)))) (-76.30) ............................................AACAUUCAUUGUUGUCGGUGGGUUG....................................................................................... 1 1 hsa-mir-181d_L01_M ES_Dicer-DEL hsa-mir-182 chr7:129197439-129197588 - CUCCUGGGGGGAGCUGCUUGCCUCCCCCCGUUUUUGGCAAUGGUAGAACUCACACUGGUGAGGUAACAGGAUCCGGUGGUUCUAGACUUGCCAACUAUGGGGCGAGGACUCAGCCGGCACCCUGUGCAC .....(.((((.((((((..((((.((((((..(((((((.(.((((((...((((((..............))))))))))))..))))))))..)))))).))))....)).)))).)))).).... (-54.34) ................................UUUGGCAAUGGUAGAACUCACAC.......................................................................... 2 1 hsa-mir-182_L01_M ES_Dicer-DEL hsa-mir-183 chr7:129201961-129202110 - GGUCGGCAGGCCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGAGGGCCUCCGGA ..((((.(((((.(...(((.((.(((((((((((.((((((..(((((..(((((((((((......)))..)))))))))))))....)))))).))))))))).))....)))))..)))))))))). (-56.70) ....................................UAUGGCACUGGUAGAAUUCAC.......................................................................... 4 1 hsa-mir-183_L01_M ES_Dicer-DEL hsa-mir-191 chr3:49033035-49033166 - CCCCCGCCAACGGCUGGACAGCGGGCAACGGAAUCCCAAAAGCAGCUGUUGUCUCCAGAGCAUUCCAGCUGCGCUUGGAUUUCGUCCCCUGCUCUCCUGCCUGAGCAGCGC .....((((..(((.(((.((((((..(((((((((.((..(((((((..((((....)).))..)))))))..)))))))))))..)))))).))).))))).))..... (-51.20) .........................................................................................UGCUCUCCUGCCUGAGCAGC.. 1 1 hsa-mir-191_R01_M ES_Dicer-DEL hsa-mir-205 chr1:207672081-207672230 + CCCUCUGAGAAAAAGAUCCUCAGACAAUCCAUGUGCUUCUCUUGUCCUUCAUUCCACCGGAGUCUGUCUCAUACCCAACCAGAUUUCAGUGGAGUGAAGUUCAGGAGGCAUGGAGCUGACAACCAUGAGGCC .((((((.((......)).((((....(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))).))))....)).)))).. (-52.72) ............................................UCCUUCAUUCCACCGGAGUC.................................................................... 1 1 hsa-mir-205_L01_M ES_Dicer-DEL hsa-mir-369 chr14:100601668-100601777 + UCCUGGUACUUGAAGGGAGAUCGACCGUGUUAUAUUCGCUUUAUUGACUUCGAAUAAUACAUGGUUGAUCUUUUCUCAGUAUCAAAUCUC ...(((((((.((..(((((((((((((((..((((((............))))))..)))))))))))))))..)))))))))...... (-36.00) ....................................................AAUAAUACAUGGUUGAUCUUU................. 2 1 hsa-mir-369_R01_M ES_Dicer-DEL .................................................UCGAAUAAUACAUGGUUGAUCUUU................. 1 1 hsa-mir-369_R02 ES_Dicer-DEL hsa-mir-451 chr17:24212493-24212604 - UGCCAGGGCACUUGGGAAUGGCAAGGAAACCGUUACCAUUACUGAGUUUAGUAAUGGUAAUGGUUCUCUUGCUAUACCCAGAAAACGUGCC ......((((((((((.((((((((..(((((((((((((((((....)))))))))))))))))..)))))))).))))).....))))) (-50.80) ..........................AAACCGUUACCAUUACUGAGUUU.......................................... 4 1 hsa-mir-451_L01_M ES_Dicer-DEL ..............................CGUUACCAUUACUGAGUUUAGU....................................... 1 1 hsa-mir-451_O01 ES_Dicer-DEL hsa-mir-558 chr2:32610704-32610837 + UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUUAUUUUGGUAUAGUAGCUCUAGACUCUAUUAUAGUUUCCUGAGCUGCUGUACCAAAAUACCACAAACGGGCUGGCUUAAAACA ........(((...((.((..((.(((.((((((.((((((((((((((((((..((..(((...)))..))..)))))))))))))))))))))))).))).))..)).))..))) (-46.80) .GUGUGUGUGUGUGUGUGUGUGUG............................................................................................. 1 1 hsa-mir-558_L01_M ES_Dicer-DEL hsa-mir-636 chr17:72244107-72244245 - CGGCGAGAUAAUGGCGGCCUGGGCGGGAGCGCGCGGGCGGGGCCGGCCCCGCUGCCUGGAAUUAACCCCGCUGUGCUUGCUCGUCCCGCCCGCAGCCCUAGGCGGCGUCGCCGCAGCCG ((((.......(((.(((.(((((((((((((((((.((((((((((......))).))......)))))))))))..))...)))))))))..)))))).(((((...))))).)))) (-63.60) ............................GCGCGCGGGCGGGGCCGG......................................................................... 1 1 hsa-mir-636_L01_M ES_Dicer-DEL hsa-mir-720 chr3:165541803-165541952 + GGAGCGAGACCGGAUCUCACACGGUGGUGUUAAUAUCUCGCUGGGGCCUCCAAAAUGUUGUGCCCAGGGGUGUUAGAGAAAACACCACACUUUGAGAUGAAUUAAGAGUCCUUUAUUAGCCGGCGACCG ((..((...((((.(((((....((((((((((((((((....(((((..(.....)..).)))).)))))))))......)))))))....)))))..(((.(((....))).)))..)))))).)). (-39.50) ..................................AUCUCGCUGGGGCCUCCA............................................................................. 3 1 hsa-mir-720_L01_M ES_Dicer-DEL hsa-mir-923 chr17:30502272-30502366 - AAUUUAAGCAUAUUUGUCAGCGGAGGAAAAGAAACUAACCAGGAUUCCCUCAGUAAUGGCGAGUGAACAGGGAA ..........(((((((((((.((((....(((.((.....)).))))))).))..)))))))))......... (-14.10) ..................................CUAACCAGGAUUCCCUCAG..................... 4 1 hsa-mir-923_O01 ES_Dicer-DEL ......................GAGGAAAAGAAACUAACCAGGA.............................. 2 1 hsa-mir-923_O02 ES_Dicer-DEL .................................ACUAACCAGGAUUCCCUCAG..................... 2 1 hsa-mir-923_O03 ES_Dicer-DEL ...................................UAACCAGGAUUCCCUCAG..................... 1 1 hsa-mir-923_O04 ES_Dicer-DEL hsa-mir-1248 chr3:187987135-187987280 + GAUUGUUAGACAUUAUUUUACCUUCUUGUAUAAGCACUGUGCUAAAAUUGCAGACACUAGGACCAUGUCUUGGUUUUUGCAAUAAUGCUAGCAGAGUACACACAAGAAGAAAAGUAACAGCACUAGAUUGUAA ((((........(((((((..((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).)))))))........)))).... (-36.69) ...........................GUAUAAGCACUGUGCUAAA....................................................................................... 1 1 hsa-mir-1248_L01_M ES_Dicer-DEL ......................UUCUUGUAUAAGCACUGUGC........................................................................................... 1 1 hsa-mir-1248_L02 ES_Dicer-DEL hsa-mir-1274a chr5:41511471-41511581 + UUUGUCCCUGAUGUCCCUGUUUGUCCCUGUUCAGGCGCCACCUGUGGCUGUCUGCCACAAGUACUAUUUGAGACCAUCACUACGACAGUU .(((((..(((((((.(.....((.(.(((.(((((((((....)))).)))))..))).).)).....).)).)))))....))))).. (-23.80) .....................UGUCCCUGUUCAGGCGCCA.................................................. 5 1 hsa-mir-1274a_L01_M ES_Dicer-DEL ......................GUCCCUGUUCAGGCGCCA.................................................. 1 1 hsa-mir-1274a_L02 ES_Dicer-DEL hsa-mir-1274b chr19:62716167-62716273 - UCCAGCAGACCUUCUUCACUCACGUCCCUGUUCGGGCGCCACUUGUGGCUGUCGGUUCGGGACUGAAUGAAGAAGGACAAAUGCAG ....(((..(((((((((.(((.(((((.(..(.(((((((....)))).))).)..))))))))).))))))))).....))).. (-40.40) .......................GUCCCUGUUCGGGCGCCA............................................. 10 1 hsa-mir-1274b_L01_M ES_Dicer-DEL ...................UCACGUCCCUGUUCGGGCGCCA............................................. 1 1 hsa-mir-1274b_L02 ES_Dicer-DEL hsa-mir-1826 chr16:33872989-33873113 + GCAGGACAGAUUGAUCAUCGACACUUCGAACGCAAUUGCAGCCCGGGUUCCUCCCAGGGCUUUGCCUGUCUGAGCGUCGCUUGCCGAUCAGUAGUCCCCGGGGGU ...((((..(((((((..((((.(((.((..((((....((((((((.....))).)))))))))...)).))).))))......))))))).))))........ (-37.40) .............AUCAUCGACACUUCGAACG......................................................................... 1 1 hsa-mir-1826_L01*_M ES_Dicer-DEL ............GAUCAUCGACACUUCGAACG......................................................................... 1 1 hsa-mir-1826_L02* ES_Dicer-DEL ...............................................................GCCUGUCUGAGCGUCGCU........................ 126 1 hsa-mir-1826_R01_M ES_Dicer-DEL