ID: mmu-mir-7060
GENE: Fbs1(7)
chr7:134632715-134632951+


(1)
AGO.mut
(3)
AGO1.ip
(12)
AGO2.ip
(2)
AGO3.ip
(9)
B-CELL
(27)
BRAIN
(1)
CELL-LINE
(2)
DCR.mut
(3)
DGCR8.mut
(14)
EMBRYO
(8)
ESC
(6)
FIBROBLAST
(2)
HEART
(1)
KIDNEY
(5)
LIVER
(1)
LUNG
(4)
LYMPH
(20)
OTHER
(1)
OTHER.ip
(11)
OTHER.mut
(4)
PIWI.ip
(3)
PIWI.mut
(10)
SKIN
(10)
SPLEEN
(1)
TDRD1.ip
(36)
TESTES
(1)
THYMUS
(1)
UTERUS

Sense strand
GGCTGCTCTCTCCAACGGGGCCTTTGGAGGCCTGGGCAGCCCCACATTCAGTGAGTGCTGGGTAGAATGGGAAATGAGGGATGGAAGCTGCAACCGAGGGGCTATAGGCTCAAGCTGGGCTTGTGATGCTCTCTGTAGAGCATCCTCCTCTCGGCCCCTGTCACTTTCTACTCTACCTTCTACTCAGACTCCAGCGCCGTCTTTGCCCAGAAAGAAAGCCCAGGAGCCCCACCAGCC
...................................................((((((..(((((((.((((((.(((.((..((.........((((((((..((((((((.....))))))))((((((((....))))))))..)))))))))).)).))).)))))).)))))))..))))))...................................................
..................................................51......................................................................................................................................187................................................
SizePerfect hitTotal NormPerfect NormSRR546155(SRX180174)
Global profiling of miRNA and the hairpin pre. (ago2 Neuroblastoma)
mjTestesWT4()
Testes Data. (testes)
SRR402760(SRX117943)
source: ES E14 male cells. (ESC)
SRR553583(SRX182789)
source: Cerebellum. (Cerebellum)
SRR402762(SRX117945)
source: ES E14 male cells. (ESC)
SRR346424(SRX098266)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)
SRR391852(GSM852147)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)
SRR391853(GSM852148)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)
SRR390297(GSM849855)
cell line: NIH-3T3cell type: fibroblastip ant. (fibroblast)
SRR248524(GSM733812)
cell type: Thy1+ spermatogonial stem cellstra. (testes)
SRR042458(GSM539850)
mouse basophil cells [09-002]. (b cell)
SRR073954(GSM629280)
total RNA. (blood)
Ago1IP812(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)
SRR391851(GSM852146)
gender: femalegenotype/variation: wild typeti. (embryo)
mjTestesWT1()
Testes Data. (testes)
SRR028732(GSM400969)
Mili-Tdrd1 KO associated. (mili testes)
mjLiverWT3()
Liver Data. (liver)
SRR040488(GSM533911)
E18.5 wild type LIVER small RNA. (liver)
SRR248523(GSM733811)
cell type: Thy1+ spermatogonial stem cellstra. (testes)
SRR014235(GSM319959)
2 dpp total. (testes)
Ago2IP504(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)
SRR059769(GSM562831)
Treg_Drosha. (spleen)
SRR553602(SRX182808)
source: Sertoli cells. (Sertoli cells)
SRR042471(GSM539863)
mouse TFHS cells [09-002]. (spleen)
SRR279907(GSM689057)
cell type: mouse embryonic stem cellcell line. (ESC)
SRR553582(SRX182788)
source: Brain. (Brain)
SRR391848(GSM852143)
gender: femalegenotype/variation: wild typeti. (embryo)
SRR039184(GSM485324)
shLuc.1309 (+dox). (fibroblast)
mjTestesKO7()
Testes Data. (Zcchc11 testes)
Ago1IP517(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)
SRR042456(GSM539848)
mouse hematopoetic progenitor cells [09-002]. (bone marrow)
SRR037921(GSM510459)
e12p5_rep3. (embryo)
SRR346423(SRX098265)
Global profiling of miRNA and the hairpin pre. (Brain)
SRR345197(SRX097258)
source: size fractionated RNA from mouse hipp. (brain)
GSM509278(GSM509278)
small RNA cloning by length. (piwi testes)
mjTestesKO6()
Testes Data. (Zcchc11 testes)
mjTestesKO8()
Testes Data. (Zcchc11 testes)
SRR042463(GSM539855)
mouse natural killer cells [09-002]. (spleen)
mjLiverKO1()
Liver Data. (Zcchc11 liver)
mjLiverKO3()
Liver Data. (Zcchc11 liver)
SRR391850(GSM852145)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)
SRR391845(GSM852140)
gender: femalegenotype/variation: wild typeti. (embryo)
SRR042470(GSM539862)
mouse Th17 cells [09-002]. (lymph)
SRR402766(SRX117949)
source: ES PGK female cells. (ESC)
SRR346425(SRX098267)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)
SRR034118(GSM466728)
Mili IP_Tdrd9+/- replicate1. (mili testes)
SRR345198(SRX097259)
source: size fractionated RNA from mouse hipp. (brain)
GSM475280(GSM475280)
Mili-IP. (mili testes)
SRR248527(GSM733815)
cell type: spermatogonial stem cell enriched . (testes)
SRR306537(GSM750580)
19-24nt. (ago2 brain)
SRR039186(GSM485326)
shLuc.1309;ROSA-rtTA (+dox). (fibroblast)
SRR553584(SRX182790)
source: Heart. (Heart)
SRR306542(GSM750585)
19-24nt. (ago2 brain)
SRR553586(SRX182792)
source: Testis. (testes)
SRR034119(GSM466729)
Mili IP_Tdrd9+/- replicate2. (mili testes)
SRR039183(GSM485323)
shLuc.1309 (-dox). (fibroblast)
SRR039185(GSM485325)
shLuc.1309;ROSA-rtTA (-dox). (fibroblast)
GSM317183(GSM317183)
Ago-1 IP small RNAs from mouse brain. (ago1 brain)
SRR038742(GSM527277)
small RNA-Seq. (dgcr8 brain)
SRR402761(SRX117944)
source: ES E14 male cells. (ESC)
SRR042459(GSM539851)
mouse neutrophil cells replicate 1 [09-002]. (blood)
SRR525238(SRA056111/SRX170314)
Second IgG control. (Blood)
SRR073955(GSM629281)
total RNA. (blood)
SRR042445(GSM539837)
mouse immature B cells [09-002]. (b cell)
GSM509279(GSM509279)
MVH-/- E16.5 small RNA. (testes)
SRR042472(GSM539864)
mouse iTreg cells [09-002]. (lymph)
SRR345196(SRX097257)
source: size fractionated RNA from mouse hipp. (brain)
SRR391847(GSM852142)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)
SRR525243(SRA056111/SRX170319)
Mus musculus domesticus miRNA sequencing. (ago2 Blood)
Ago3IP805(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)
SRR051939(GSM545783)
Mov10L1-associated piRNAs. (mov10L testes)
SRR039154(GSM471931)
HL1_siSrf2_smallRNAseq. (muscle)
SRR042450(GSM539842)
mouse B cells activated in vitro with LPS/IL4 replicate 3 [09-002]. (b cell)
SRR040489(GSM533912)
E18.5 Ago2 catalytically inactive LIVER small RNA. (ago2 liver)
mjTestesWT2()
Testes Data. (testes)
SRR038741(GSM527276)
small RNA-Seq. (brain)
Ago3IP812(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)
mjTestesKO5()
Testes Data. (Zcchc11 testes)
SRR042454(GSM539846)
mouse germinal center B cells (lymph node) [09-002]. (b cell)
SRR391846(GSM852141)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)
SRR014236(GSM319960)
10 dpp total. (testes)
SRR042469(GSM539861)
mouse Th2 cells [09-002]. (lymph)
SRR042473(GSM539865)
mouse nTreg cells [09-002]. (lymph)
SRR069809(GSM610965)
small RNA sequencing; sample 1. (testes)
SRR306536(GSM750579)
19-24nt. (ago2 brain)
SRR279905(GSM689055)
cell type: mouse embryonic stem cellcell line. (ESC)
SRR042451(GSM539843)
mouse B cells activated in vitro with LPS/aIgD-Dextran [09-002]. (b cell)
SRR039152(GSM471929)
HL1_siNon_smallRNAseq. (muscle)
SRR306528(GSM750571)
19-24nt. (ago2 brain)
SRR206941(GSM723282)
other. (brain)
SRR346421(SRX098263)
Global profiling of miRNA and the hairpin pre. (mixture)
SRR059766(GSM562828)
DN3_Drosha. (thymus)
Ago2IP517(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)
SRR391849(GSM852144)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)
SRR059770(GSM562832)
Treg_Dicer. (spleen)
RuiDGCR8KO(Rui)
DGCR8-dependent microRNA biogenesis is essent. (dgcr8 skin)
SRR029037(GSM433289)
18dpp_homo_tdrd6-KO. (tdrd6 testes)
SRR037905(GSM510441)
brain_rep2. (brain)
SRR042455(GSM539847)
mouse plasma cells [09-002]. (blood)
GSM509280(GSM509280)
small RNA cloning by length. (testes)
SRR306526(GSM750569)
19-24nt. (ago2 brain)
SRR042467(GSM539859)
mouse T cells activated in vitro with Concanavalin A [09-002]. (spleen)
SRR042477(GSM539869)
mouse brain tissue [09-002]. (brain)
SRR042465(GSM539857)
mouse CD4+ T cells (spleen) [09-002]. (spleen)
SRR345202(SRX097263)
source: size fractionated RNA from mouse hipp. (brain)
SRR038743(GSM527278)
small RNA-Seq. (dicer brain)
SRR042480(GSM539872)
mouse kidney tissue [09-002]. (kidney)
SRR042448(GSM539840)
mouse B cells activated in vitro with LPS/IL4 replicate 1 [09-002]. (b cell)
SRR029042(GSM433294)
18.5dpc_hetero_tdrd1-KO. (tdrd1 testes)
SRR206940(GSM723281)
other. (brain)
SRR037922(GSM510460)
e12p5_rep4. (embryo)
SRR038745(GSM527280)
small RNA-Seq. (dgcr8 brain)
SRR029043(GSM433295)
18.5dpc_homo_tdrd1-KO. (tdrd1 testes)
SRR553604(SRX182810)
source: Spermatocytes. (Spermatocytes)
SRR248526(GSM733814)
cell type: Thy1- spermatogonial stem cellstra. (testes)
SRR042447(GSM539839)
mouse mature B cells (spleen) replicate 2 [09-002]. (b cell)
SRR059772(GSM562834)
CD4_Drosha. (spleen)
SRR306527(GSM750570)
19-24nt. (ago2 brain)
SRR029036(GSM433288)
18dpp_hetero_tdrd6-KO. (tdrd6 testes)
SRR248525(GSM733813)
cell type: Thy1- spermatogonial stem cellstra. (testes)
SRR346422(SRX098264)
Global profiling of miRNA and the hairpin pre. (Muscle)
GSM509276(GSM509276)
small RNA cloning by length. (testes)
SRR042475(GSM539867)
mouse embryonic fibroblast cells [09-002]. (fibroblast)
SRR306540(GSM750583)
19-24nt. (ago2 brain)
SRR059771(GSM562833)
CD4_control. (spleen)
SRR346419(SRX098260)
Global profiling of miRNA and the hairpin pre. (Lung)
GSM314557(GSM314557)
ESC dgcr8 (Illumina). (ESC)
SRR525244(SRA056111/SRX170320)
Mus musculus domesticus miRNA sequencing. (ago2 Blood)
SRR042487(GSM539879)
mouse BclXL B activated with LPS/IL4 [BalbC] [09-002]. (spleen)
SRR345199(SRX097260)
source: size fractionated RNA from mouse hipp. (brain)
SRR042449(GSM539841)
mouse B cells activated in vitro with LPS/IL4 replicate 2 [09-002]. (b cell)
SRR023852(GSM307161)
ZHBT-c424hsmallrna_rep1. (cell line)
SRR279903(GSM689053)
cell type: mouse embryonic stem cellcell line. (ESC)
SRR346414(SRX098255)
Global profiling of miRNA and the hairpin pre. (Spleen)
SRR345203(SRX097264)
source: size fractionated RNA from mouse hipp. (brain)
SRR029038(GSM433290)
25dpp_hetero_tdrd6-KO. (tdrd6 testes)
SRR014229(GSM319953)
10 dpp MILI. (mili testes)
SRR042462(GSM539854)
mouse macrophages [09-002]. (bone marrow)
SRR038744(GSM527279)
small RNA-Seq. (brain)
SRR037920(GSM510458)
e12p5_rep2. (embryo)
SRR042457(GSM539849)
mouse mast cells [09-002]. (bone marrow)
SRR042443(GSM539835)
mouse pro B cells [09-002]. (b cell)
SRR346420(SRX098261)
Global profiling of miRNA and the hairpin pre. (Uterus)
GSM509277(GSM509277)
small RNA cloning by length. (piwi testes)
SRR037919(GSM510457)
e12p5_rep1. (embryo)
GSM475281(GSM475281)
total RNA. (testes)
SRR042476(GSM539868)
mouse heart tissue [09-002]. (heart)
SRR014231(GSM319955)
16.5 dpc total. (testes)
SRR346415(SRX098256)
source: Testis. (Testes)
SRR028730(GSM400967)
Tdrd1-associated. (tdrd1 testes)
SRR039610(GSM527274)
small RNA-Seq. (brain)
SRR037924(GSM510462)
e9p5_rep2. (embryo)
SRR345204(SRX097265)
source: size fractionated RNA from mouse hipp. (brain)
RuiDcrKO(Rui)
DGCR8-dependent microRNA biogenesis is essent. (dicer skin)
RuiDGCR8WT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)
RuiDcrWT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)
..................................................GTGAGTGCTGGGTAGAATGGGA.....................................................................................................................................................................22193.0093.005.00-12.006.00-4.003.001.009.001.002.00-2.003.00----1.00--1.002.002.00-2.00-1.00-1.00-----1.002.001.00--1.00-1.001.00-----2.00-2.001.00--1.00---1.001.00--1.00-1.00-1.001.00--2.001.00---1.00-1.00-------1.00-2.00--2.001.00-----------1.00----------------1.00---1.00----1.00----------1.00--------------
......................................................................................................................................................................TCTACTCTACCTTCTACTCAGT.................................................22170.005.0011.00-3.00-1.00-1.002.00--1.002.003.00---5.003.00--2.001.00-----2.00-1.001.001.00-------2.002.002.00-------1.00---1.00-2.002.003.00----1.00----1.00----1.001.00-1.00---1.00----1.00---------1.00----------1.00----1.00------1.00-----------------1.00---1.00----1.00-----1.00-----
..................................................GTGAGTGCTGGGTAGAATGGG......................................................................................................................................................................21141.0041.006.0012.00---1.002.001.00-1.002.00---------3.00-1.003.00-1.001.00-------------------------1.00----------------1.00-----1.00--1.00--------1.00----------1.00----1.00----------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGG.......................................................................................................................................................................20140.0040.007.00--1.00-1.00----------------1.00-5.002.00------3.00---1.00-------2.00-2.00----1.00------3.00--2.00------------1.00--1.00------1.00----1.00----------1.00--------1.00----1.00-----------1.00-----1.00-----------------------
..................................................GTGAGTGCTGGGTAGAATGGGAA....................................................................................................................................................................23137.0037.001.00--2.001.001.006.002.00-----1.00--------------2.00-2.00------2.00-2.00---1.001.00-------1.00---------------1.00------------1.00----1.001.00-1.00-----------------1.00--------------1.001.00----1.00-----------------1.00----1.001.00---
......................................................................................................................................................................TCTACTCTACCTTCTACTCAGA.................................................22132.0032.003.004.00-1.008.001.00------1.001.00--1.00----1.00----1.00--1.00-3.00-----------1.00---------------2.00---------------------------------------------------1.00-------------------1.00-1.00----------------------
...................................................TGAGTGCTGGGTAGAATGGGAAATG.................................................................................................................................................................25113.0013.00---------2.00-----2.00--1.001.00--------------1.00------------2.00----------------1.00---------------1.00-------------------------------------------------------1.00------1.00------------
..................................................GTGAGTGCTGGGTAGAATGGGAAA...................................................................................................................................................................24112.0012.00-----1.00-3.00--1.00----------1.00------------1.00-------1.00-------1.00------------------------------1.001.00----------1.00--------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAATG.................................................................................................................................................................2618.008.00---------1.00--------1.00----------------2.001.00-------------------------------------1.00---------------------------------1.00----------------------------------------1.00------
..................................................GTGAGTGCTGGGTAGAATGGGAAT...................................................................................................................................................................2418.0037.002.00----1.00-2.00-----2.00--------1.00-------------------------------------------------------------------------------------------------------------------------------------
........................................................................................TGCAACCGAGGGGCTATAGGCTCAAGCTGG.......................................................................................................................3017.007.00--------------7.00---------------------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCTGGGTAGAATGGGAAATGA................................................................................................................................................................2616.006.00---------------1.00--1.001.00--------------1.00-----------------------------1.00-----------------------------------------------1.00-------------------------------------------
......................................................................................................................................................................TCTACTCTACCTTCTACTCAG..................................................2115.005.00----1.00---------------------------------4.00---------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................TTCTACTCTACCTTCTACTCAGT.................................................235.000.003.00----------1.00--------------------------------------------1.00---------------------------------------------------------------------------------------------------
...................................................TGAGTGCTGGGTAGAATGGGAAAT..................................................................................................................................................................2414.004.00---------1.00------------------1.00-----1.00-----------------------------1.00-------------------------------------------------------------------------------------------
.....................................................AGTGCTGGGTAGAATGGGAAATGAGGG.............................................................................................................................................................2714.004.00---------1.00--------------------------------------1.00-------------------------------1.00--------------------------------------1.00------------------------------------
........................................................................................TGCAACCGAGGGGCTATAGGCTCAAGC..........................................................................................................................2714.004.00-----------------------------------------------1.00-----------------------------1.00------------------1.00----------------1.00------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAT....................................................................................................................................................................2314.0093.00-----1.00---------------------------------------------------------1.00--------------------------------------------------------1.00-------------------1.00---------------
..................................................GTGAGTGCTGGGTAGAATGGT......................................................................................................................................................................2113.0040.00---1.00--------------------------------------------------------1.00--------1.00--------------------------------------------------------------------------------------
...................................................TGAGTGCTGGGTAGAATGGGAAA...................................................................................................................................................................2313.003.00----------1.00-----------------------------------------------------------2.00-------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGT.....................................................................................................................................................................2213.0041.001.00----1.00-------------------------------------------------------------------------------------------------------------------------1.00----------------------------
....................CCTTTGGAGGCCTGGGAA.......................................................................................................................................................................................................182.000.00------------------------------------------------------------------2.00-----------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAAT..................................................................................................................................................................2512.002.001.00------------------1.00----------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGAAT.....................................................................................................................................................................2212.001.00-----------------------------------------------------2.00------------------------------------------------------------------------------------------------------
...................................................TGAGTGCTGGGTAGAATGGGAA....................................................................................................................................................................2212.002.00---------------------------------------------------------------------------------------------------1.00---------------1.00----------------------------------------
.....................................................AGTGCTGGGTAGAATGGGAAATGAGG..............................................................................................................................................................2612.002.00---------2.00--------------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAAAA.................................................................................................................................................................2612.0012.00-----------------2.00------------------------------------------------------------------------------------------------------------------------------------------
.....................................................AGTGCTGGGTAGAATGGGAAATGAGGGA............................................................................................................................................................2812.002.00---------------2.00--------------------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................TCTACTCTACCTTCTACTCAGTT................................................2312.005.001.00-----------------------------------------------------------1.00-----------------------------------------------------------------------------------------------
...................................................TGAGTGCTGGGTAGAATGGGA.....................................................................................................................................................................2112.002.001.00-----------1.00-----------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAATGA................................................................................................................................................................2712.002.00-------------------1.00--------1.00-------------------------------------------------------------------------------------------------------------------------------
........................TGGAGGCCTGGGCAGCCCCACA...............................................................................................................................................................................................2212.002.00--------------------------2.00---------------------------------------------------------------------------------------------------------------------------------
......................................................................................................................................................................TCTACTCTACCTTCTACTCAGG.................................................2212.005.001.00------------------------------------------------------------------------------1.00----------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAATA.................................................................................................................................................................2612.002.00---------------------------------------------1.00--------1.00-----------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGA......................................................................................................................................................................2112.0040.001.00--1.00--------------------------------------------------------------------------------------------------------------------------------------------------------
..........TCCAACGGGGCCTTTCCT.................................................................................................................................................................................................................1831.670.33-----------------------------------------------------------------------------------------------0.33---------------------------------------------------------0.67-0.67
..................................................GTGAGTGCTGGGTAGAATGGGTT....................................................................................................................................................................2311.0041.00----------1.00-------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................TGCTCTCTGTAGAGCATCCTCCTCTCGGCT.................................................................................301.000.00------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................................TTGCCCAGAAAGAAAGCCCAGGAGCCCC.......2811.001.00-------------------1.00----------------------------------------------------------------------------------------------------------------------------------------
..........................................................................................................................................................................................GACTCCAGCGCCGTCCCT.................................181.000.00----------------------------------------------------------------------------------------------------------------------1.00-------------------------------------
.............................................................................................................................................................................................TCCAGCGCCGTCTTTTGTT.............................191.000.00---------------------------------1.00--------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................CTTTCTACTCTACCTTCTACTCAGT.................................................251.000.00-------------------------------------------------------------------------1.00----------------------------------------------------------------------------------
.......................................................TGCTGGGTAGAATGGGAAATGA................................................................................................................................................................2211.001.001.00-----------------------------------------------------------------------------------------------------------------------------------------------------------
.......................................................TGCTGGGTAGAATGGGAAATGAGGGA............................................................................................................................................................2611.001.00------------------------------------------------------1.00-----------------------------------------------------------------------------------------------------
...................................................TGAGTGCTGGGTAGAATGGGAAATGAGGC.............................................................................................................................................................291.000.00------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------
............................................................................................................CTCAAGCTGGGCTTGTGATGCTCTC........................................................................................................2511.001.00-----------------------------------1.00------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAATGAAA..............................................................................................................................................................2911.002.00------------------1.00-----------------------------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................................TTCTACTCTACCTTCTACTCAGA.................................................2311.001.00----1.00-------------------------------------------------------------------------------------------------------------------------------------------------------
..............ACGGGGCCTTTGGAGGC..............................................................................................................................................................................................................1711.001.00----------------------------------------------------------------------------------------------------------------------------------------------------1.00-------
..................................................GTGAGTGCTGGGTAGAAT.........................................................................................................................................................................1811.001.00--------------------------------------------------1.00---------------------------------------------------------------------------------------------------------
......................................................................................................................................................................TCTACTCTACCTTCTACTCA...................................................2011.001.00------------------------------------------------1.00-----------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGATAT..................................................................................................................................................................2511.0093.00---------------------1.00--------------------------------------------------------------------------------------------------------------------------------------
....................CCTTTGGAGGCCTGGGTTTT.....................................................................................................................................................................................................201.000.00-------------------------------------------------------------------------------------------------1.00----------------------------------------------------------
......................................................................................................................................................................TCTACTCTACCTTCTACTCAGC.................................................2211.005.00-----------------------------1.00------------------------------------------------------------------------------------------------------------------------------
.....................................................AGTGCTGGGTAGAATGGGAAATGAGGAA............................................................................................................................................................2811.002.00---------------1.00--------------------------------------------------------------------------------------------------------------------------------------------
..........TCCAACGGGGCCTTTCCTT................................................................................................................................................................................................................1931.000.33--------------------------0.33--------------------------------------------------------------------0.67------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGA.......................................................................................................................................................................2011.001.00---1.00--------------------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGTGA.....................................................................................................................................................................2211.001.00------------------------------------------------------------------------------------------------------1.00-----------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGTGAT....................................................................................................................................................................2311.001.00---------------------------------------------------------------1.00--------------------------------------------------------------------------------------------
...........................................................................................AACCGAGGGGCTATAGGCTC..............................................................................................................................2011.001.00----------------------------------------------------------------------------1.00-------------------------------------------------------------------------------
.........................................................................................................................TGTGATGCTCTCTGTAGA..................................................................................................1811.001.00--------------------------------------------------1.00---------------------------------------------------------------------------------------------------------
....................CCTTTGGAGGCCTGGGAAGA.....................................................................................................................................................................................................201.000.00-----------------------------------------------------------------1.00------------------------------------------------------------------------------------------
.................................................................................TGGAAGCTGCAACCGAGGGGCTATAT..................................................................................................................................261.000.00---------------------------------------------1.00--------------------------------------------------------------------------------------------------------------
..............ACGGGGCCTTTGGAGGCCTGGGCAGCCC...................................................................................................................................................................................................2811.001.00-------------------------------------------------------------------------------------1.00----------------------------------------------------------------------
....................................................................GGGAAATGAGGGATGGAAGCTGCAACCGAGGGGCTATAGGCTCAAGCTGGGCTTGTGATGCTCTCTGTAGAGCATCCTCCTCTC.....................................................................................8411.001.00------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------
.............................................................................................................................................................................................TCCAGCGCCGTCTTTGCC..............................1811.001.00-----------------1.00------------------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGC.....................................................................................................................................................................2211.0041.00--------------------------------------------------------------------------------------------1.00---------------------------------------------------------------
................................................................................................................AGCTGGGCTTGTGATGCAGCC........................................................................................................2111.001.00---------------------------------1.00--------------------------------------------------------------------------------------------------------------------------
..................................................................................................................................CTCTGTAGAGCATCCTCCTCTCGGC..................................................................................2511.001.00-----------------------------------------------------------------------------------1.00------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGTAA...................................................................................................................................................................2411.0041.00-----------------------------------------------------------------------------------------------------------------------------------------1.00------------------
.........................................................................................GCAACCGAGGGGCTATAGGCT...............................................................................................................................2111.001.00-----------------------------------------1.00------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGTGAA....................................................................................................................................................................2311.001.00----------------------------------------------------------------------------------------------------------1.00-------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGAG......................................................................................................................................................................2111.001.00---1.00--------------------------------------------------------------------------------------------------------------------------------------------------------
.............................................................................................................................................................................................TCCAGCGCCGTCTTTTTC..............................181.000.00----------------------------------------------1.00-------------------------------------------------------------------------------------------------------------
..........................................................................................................GGCTCAAGCTGGGCTTGTGATGT............................................................................................................231.000.00-------------------------------------------------------------------------------------------------------------------------------------------------1.00----------
..................................................GTGAGTGCTGGGTAGAATGGGAAATGAGGGAT...........................................................................................................................................................3211.001.00-------------------------------------------------------------1.00----------------------------------------------------------------------------------------------
....................................................GAGTGCTGGGTAGAATGGGAAT...................................................................................................................................................................221.000.00----------------------------------------------------------------------------------------------------------------------------1.00-------------------------------
................................................................................................................................................................................................................AGAAAGAAAGCCCAGGAGCCCCACC....2511.001.00-------------------------------------1.00----------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGTG......................................................................................................................................................................2111.001.00----------------------------------------------------------------------------------1.00-------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATAGGA.....................................................................................................................................................................2211.001.00-----------------------------------------------------------------------------------------------------1.00------------------------------------------------------
.........................................................................................................................TGTGATGCTCTCTGTAGAGC................................................................................................2011.001.00-------------------------------------------------------------------------------------1.00----------------------------------------------------------------------
..................................................................................................GGGCTATAGGCTCAATTGC........................................................................................................................191.000.00-----------1.00------------------------------------------------------------------------------------------------------------------------------------------------
..........................................................................TGAGGGATGGAAGCTGCAACCGAGG..........................................................................................................................................2511.001.00---------------------------------------------1.00--------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................................ACTCTACCTTCTACTCAGT.................................................191.000.00---------------------------1.00--------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAAAAT................................................................................................................................................................2711.0012.00--------------------------------1.00---------------------------------------------------------------------------------------------------------------------------
................................................................................................................AGCTGGGCTTGTGATGC............................................................................................................1711.001.00--------------------------------------------------------------------------------------------------------------------------------------1.00---------------------
..................................................GTGAGTGCTGGGTAGAATG........................................................................................................................................................................1911.001.00-----1.00------------------------------------------------------------------------------------------------------------------------------------------------------
................................................................................................................................CTCTCTGTAGAGCATCCTC..........................................................................................1911.001.00----------------------------------------------------------------------------------------------------------------------------------------------1.00-------------
..................................................GTGAGTGCTGGGTAGAATGGTA.....................................................................................................................................................................2211.0040.00------------------------------1.00-----------------------------------------------------------------------------------------------------------------------------
..................................................................................................................CTGGGCTTGTGATGCTCTCTGTAGAGCATCCTCCTCTCGGCCCCTGTCACTTTCTACTCTACCTTCTACTCAG..................................................7311.001.00------------------------------------------------------------------------------------------1.00-----------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGAATGGGAAAGG.................................................................................................................................................................2611.0012.00---------------------------------------------------------------------------------------------------------------------------------------------------1.00--------
..................................................GTGAGTGCTGGGTAGAATGGGAAATGT................................................................................................................................................................2711.008.00------------------------------------------1.00-----------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCTGGGTAGTGGG........................................................................................................................................................................191.000.00---------------------------------1.00--------------------------------------------------------------------------------------------------------------------------
..........TCCAACGGGGCCTTTCC..................................................................................................................................................................................................................1730.670.33----------------------------------------0.33-----------------------------------------------------------------------------------------------------------------0.33-
...........................................................................................................................................................................TCTACCTTCTACTCAGA.................................................1720.500.50----0.50-------------------------------------------------------------------------------------------------------------------------------------------------------
..........TCCAACGGGGCCTTT....................................................................................................................................................................................................................1530.330.33----------------------------------------------------------------------------------------------------------------------------------------------------------0.33-
...................................................................................................................................................................................................................AAGAAAGCCCAGGAGC..........1680.120.12---------------------------------------------------------------------------------------------0.12--------------------------------------------------------------

Antisense strand
GGCTGCTCTCTCCAACGGGGCCTTTGGAGGCCTGGGCAGCCCCACATTCAGTGAGTGCTGGGTAGAATGGGAAATGAGGGATGGAAGCTGCAACCGAGGGGCTATAGGCTCAAGCTGGGCTTGTGATGCTCTCTGTAGAGCATCCTCCTCTCGGCCCCTGTCACTTTCTACTCTACCTTCTACTCAGACTCCAGCGCCGTCTTTGCCCAGAAAGAAAGCCCAGGAGCCCCACCAGCC
...................................................((((((..(((((((.((((((.(((.((..((.........((((((((..((((((((.....))))))))((((((((....))))))))..)))))))))).)).))).)))))).)))))))..))))))...................................................
..................................................51......................................................................................................................................187................................................
SizePerfect hitTotal NormPerfect NormSRR546155(SRX180174)
Global profiling of miRNA and the hairpin pre. (ago2 Neuroblastoma)
mjTestesWT4()
Testes Data. (testes)
SRR402760(SRX117943)
source: ES E14 male cells. (ESC)
SRR553583(SRX182789)
source: Cerebellum. (Cerebellum)
SRR402762(SRX117945)
source: ES E14 male cells. (ESC)
SRR346424(SRX098266)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)
SRR391852(GSM852147)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)
SRR391853(GSM852148)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)
SRR390297(GSM849855)
cell line: NIH-3T3cell type: fibroblastip ant. (fibroblast)
SRR248524(GSM733812)
cell type: Thy1+ spermatogonial stem cellstra. (testes)
SRR042458(GSM539850)
mouse basophil cells [09-002]. (b cell)
SRR073954(GSM629280)
total RNA. (blood)
Ago1IP812(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)
SRR391851(GSM852146)
gender: femalegenotype/variation: wild typeti. (embryo)
mjTestesWT1()
Testes Data. (testes)
SRR028732(GSM400969)
Mili-Tdrd1 KO associated. (mili testes)
mjLiverWT3()
Liver Data. (liver)
SRR040488(GSM533911)
E18.5 wild type LIVER small RNA. (liver)
SRR248523(GSM733811)
cell type: Thy1+ spermatogonial stem cellstra. (testes)
SRR014235(GSM319959)
2 dpp total. (testes)
Ago2IP504(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)
SRR059769(GSM562831)
Treg_Drosha. (spleen)
SRR553602(SRX182808)
source: Sertoli cells. (Sertoli cells)
SRR042471(GSM539863)
mouse TFHS cells [09-002]. (spleen)
SRR279907(GSM689057)
cell type: mouse embryonic stem cellcell line. (ESC)
SRR553582(SRX182788)
source: Brain. (Brain)
SRR391848(GSM852143)
gender: femalegenotype/variation: wild typeti. (embryo)
SRR039184(GSM485324)
shLuc.1309 (+dox). (fibroblast)
mjTestesKO7()
Testes Data. (Zcchc11 testes)
Ago1IP517(Rui)
Quantitative functions of Argonaute proteins . (ago1 skin)
SRR042456(GSM539848)
mouse hematopoetic progenitor cells [09-002]. (bone marrow)
SRR037921(GSM510459)
e12p5_rep3. (embryo)
SRR346423(SRX098265)
Global profiling of miRNA and the hairpin pre. (Brain)
SRR345197(SRX097258)
source: size fractionated RNA from mouse hipp. (brain)
GSM509278(GSM509278)
small RNA cloning by length. (piwi testes)
mjTestesKO6()
Testes Data. (Zcchc11 testes)
mjTestesKO8()
Testes Data. (Zcchc11 testes)
SRR042463(GSM539855)
mouse natural killer cells [09-002]. (spleen)
mjLiverKO1()
Liver Data. (Zcchc11 liver)
mjLiverKO3()
Liver Data. (Zcchc11 liver)
SRR391850(GSM852145)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)
SRR391845(GSM852140)
gender: femalegenotype/variation: wild typeti. (embryo)
SRR042470(GSM539862)
mouse Th17 cells [09-002]. (lymph)
SRR402766(SRX117949)
source: ES PGK female cells. (ESC)
SRR346425(SRX098267)
Global profiling of miRNA and the hairpin pre. (Neuroblastoma)
SRR034118(GSM466728)
Mili IP_Tdrd9+/- replicate1. (mili testes)
SRR345198(SRX097259)
source: size fractionated RNA from mouse hipp. (brain)
GSM475280(GSM475280)
Mili-IP. (mili testes)
SRR248527(GSM733815)
cell type: spermatogonial stem cell enriched . (testes)
SRR306537(GSM750580)
19-24nt. (ago2 brain)
SRR039186(GSM485326)
shLuc.1309;ROSA-rtTA (+dox). (fibroblast)
SRR553584(SRX182790)
source: Heart. (Heart)
SRR306542(GSM750585)
19-24nt. (ago2 brain)
SRR553586(SRX182792)
source: Testis. (testes)
SRR034119(GSM466729)
Mili IP_Tdrd9+/- replicate2. (mili testes)
SRR039183(GSM485323)
shLuc.1309 (-dox). (fibroblast)
SRR039185(GSM485325)
shLuc.1309;ROSA-rtTA (-dox). (fibroblast)
GSM317183(GSM317183)
Ago-1 IP small RNAs from mouse brain. (ago1 brain)
SRR038742(GSM527277)
small RNA-Seq. (dgcr8 brain)
SRR402761(SRX117944)
source: ES E14 male cells. (ESC)
SRR042459(GSM539851)
mouse neutrophil cells replicate 1 [09-002]. (blood)
SRR525238(SRA056111/SRX170314)
Second IgG control. (Blood)
SRR073955(GSM629281)
total RNA. (blood)
SRR042445(GSM539837)
mouse immature B cells [09-002]. (b cell)
GSM509279(GSM509279)
MVH-/- E16.5 small RNA. (testes)
SRR042472(GSM539864)
mouse iTreg cells [09-002]. (lymph)
SRR345196(SRX097257)
source: size fractionated RNA from mouse hipp. (brain)
SRR391847(GSM852142)
gender: femalegenotype/variation: ADAR2-/-/AD. (embryo)
SRR525243(SRA056111/SRX170319)
Mus musculus domesticus miRNA sequencing. (ago2 Blood)
Ago3IP805(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)
SRR051939(GSM545783)
Mov10L1-associated piRNAs. (mov10L testes)
SRR039154(GSM471931)
HL1_siSrf2_smallRNAseq. (muscle)
SRR042450(GSM539842)
mouse B cells activated in vitro with LPS/IL4 replicate 3 [09-002]. (b cell)
SRR040489(GSM533912)
E18.5 Ago2 catalytically inactive LIVER small RNA. (ago2 liver)
mjTestesWT2()
Testes Data. (testes)
SRR038741(GSM527276)
small RNA-Seq. (brain)
Ago3IP812(Rui)
Quantitative functions of Argonaute proteins . (ago3 skin)
mjTestesKO5()
Testes Data. (Zcchc11 testes)
SRR042454(GSM539846)
mouse germinal center B cells (lymph node) [09-002]. (b cell)
SRR391846(GSM852141)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)
SRR014236(GSM319960)
10 dpp total. (testes)
SRR042469(GSM539861)
mouse Th2 cells [09-002]. (lymph)
SRR042473(GSM539865)
mouse nTreg cells [09-002]. (lymph)
SRR069809(GSM610965)
small RNA sequencing; sample 1. (testes)
SRR306536(GSM750579)
19-24nt. (ago2 brain)
SRR279905(GSM689055)
cell type: mouse embryonic stem cellcell line. (ESC)
SRR042451(GSM539843)
mouse B cells activated in vitro with LPS/aIgD-Dextran [09-002]. (b cell)
SRR039152(GSM471929)
HL1_siNon_smallRNAseq. (muscle)
SRR306528(GSM750571)
19-24nt. (ago2 brain)
SRR206941(GSM723282)
other. (brain)
SRR346421(SRX098263)
Global profiling of miRNA and the hairpin pre. (mixture)
SRR059766(GSM562828)
DN3_Drosha. (thymus)
Ago2IP517(Rui)
Quantitative functions of Argonaute proteins . (ago2 skin)
SRR391849(GSM852144)
gender: femalegenotype/variation: ADAR2-/-tis. (embryo)
SRR059770(GSM562832)
Treg_Dicer. (spleen)
RuiDGCR8KO(Rui)
DGCR8-dependent microRNA biogenesis is essent. (dgcr8 skin)
SRR029037(GSM433289)
18dpp_homo_tdrd6-KO. (tdrd6 testes)
SRR037905(GSM510441)
brain_rep2. (brain)
SRR042455(GSM539847)
mouse plasma cells [09-002]. (blood)
GSM509280(GSM509280)
small RNA cloning by length. (testes)
SRR306526(GSM750569)
19-24nt. (ago2 brain)
SRR042467(GSM539859)
mouse T cells activated in vitro with Concanavalin A [09-002]. (spleen)
SRR042477(GSM539869)
mouse brain tissue [09-002]. (brain)
SRR042465(GSM539857)
mouse CD4+ T cells (spleen) [09-002]. (spleen)
SRR345202(SRX097263)
source: size fractionated RNA from mouse hipp. (brain)
SRR038743(GSM527278)
small RNA-Seq. (dicer brain)
SRR042480(GSM539872)
mouse kidney tissue [09-002]. (kidney)
SRR042448(GSM539840)
mouse B cells activated in vitro with LPS/IL4 replicate 1 [09-002]. (b cell)
SRR029042(GSM433294)
18.5dpc_hetero_tdrd1-KO. (tdrd1 testes)
SRR206940(GSM723281)
other. (brain)
SRR037922(GSM510460)
e12p5_rep4. (embryo)
SRR038745(GSM527280)
small RNA-Seq. (dgcr8 brain)
SRR029043(GSM433295)
18.5dpc_homo_tdrd1-KO. (tdrd1 testes)
SRR553604(SRX182810)
source: Spermatocytes. (Spermatocytes)
SRR248526(GSM733814)
cell type: Thy1- spermatogonial stem cellstra. (testes)
SRR042447(GSM539839)
mouse mature B cells (spleen) replicate 2 [09-002]. (b cell)
SRR059772(GSM562834)
CD4_Drosha. (spleen)
SRR306527(GSM750570)
19-24nt. (ago2 brain)
SRR029036(GSM433288)
18dpp_hetero_tdrd6-KO. (tdrd6 testes)
SRR248525(GSM733813)
cell type: Thy1- spermatogonial stem cellstra. (testes)
SRR346422(SRX098264)
Global profiling of miRNA and the hairpin pre. (Muscle)
GSM509276(GSM509276)
small RNA cloning by length. (testes)
SRR042475(GSM539867)
mouse embryonic fibroblast cells [09-002]. (fibroblast)
SRR306540(GSM750583)
19-24nt. (ago2 brain)
SRR059771(GSM562833)
CD4_control. (spleen)
SRR346419(SRX098260)
Global profiling of miRNA and the hairpin pre. (Lung)
GSM314557(GSM314557)
ESC dgcr8 (Illumina). (ESC)
SRR525244(SRA056111/SRX170320)
Mus musculus domesticus miRNA sequencing. (ago2 Blood)
SRR042487(GSM539879)
mouse BclXL B activated with LPS/IL4 [BalbC] [09-002]. (spleen)
SRR345199(SRX097260)
source: size fractionated RNA from mouse hipp. (brain)
SRR042449(GSM539841)
mouse B cells activated in vitro with LPS/IL4 replicate 2 [09-002]. (b cell)
SRR023852(GSM307161)
ZHBT-c424hsmallrna_rep1. (cell line)
SRR279903(GSM689053)
cell type: mouse embryonic stem cellcell line. (ESC)
SRR346414(SRX098255)
Global profiling of miRNA and the hairpin pre. (Spleen)
SRR345203(SRX097264)
source: size fractionated RNA from mouse hipp. (brain)
SRR029038(GSM433290)
25dpp_hetero_tdrd6-KO. (tdrd6 testes)
SRR014229(GSM319953)
10 dpp MILI. (mili testes)
SRR042462(GSM539854)
mouse macrophages [09-002]. (bone marrow)
SRR038744(GSM527279)
small RNA-Seq. (brain)
SRR037920(GSM510458)
e12p5_rep2. (embryo)
SRR042457(GSM539849)
mouse mast cells [09-002]. (bone marrow)
SRR042443(GSM539835)
mouse pro B cells [09-002]. (b cell)
SRR346420(SRX098261)
Global profiling of miRNA and the hairpin pre. (Uterus)
GSM509277(GSM509277)
small RNA cloning by length. (piwi testes)
SRR037919(GSM510457)
e12p5_rep1. (embryo)
GSM475281(GSM475281)
total RNA. (testes)
SRR042476(GSM539868)
mouse heart tissue [09-002]. (heart)
SRR014231(GSM319955)
16.5 dpc total. (testes)
SRR346415(SRX098256)
source: Testis. (Testes)
SRR028730(GSM400967)
Tdrd1-associated. (tdrd1 testes)
SRR039610(GSM527274)
small RNA-Seq. (brain)
SRR037924(GSM510462)
e9p5_rep2. (embryo)
SRR345204(SRX097265)
source: size fractionated RNA from mouse hipp. (brain)
RuiDcrKO(Rui)
DGCR8-dependent microRNA biogenesis is essent. (dicer skin)
RuiDGCR8WT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)
RuiDcrWT(Rui)
DGCR8-dependent microRNA biogenesis is essent. (skin)
..............................................................................................................................................................................................................................GGAGCCCCACCAGCCACA 182.000.00-----------1.00--------------------------------------------------1.00---------------------------------------------------------------------------------------------
..............................................................................................................................................................................................................................GGAGCCCCACCAGCCCCA 181.000.00-----------1.00------------------------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................CTCTCGGCCCCTGTCAAAA....................................................................... 191.000.00-----------------------------------------------------------------------------------1.00------------------------------------------------------------------------
.............................................................................................................................................................................................................................AGGAGCCCCACCAGCCCC 181.000.00-----------1.00------------------------------------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................................................................................GGAGCCCCACCAGCCAAA 181.000.00--------------------------------------------------------------1.00---------------------------------------------------------------------------------------------
...................................................................................................................................................................CTTTCTACTCTACCTATGA....................................................... 191.000.00------------------------------------------------------------------------------------------------------------------------------------------1.00-----------------
...............................................................................................................................................CCTCCTCTCGGCCCCGAAG........................................................................... 191.000.00--------------------------------------------------------------------------------------------------------------------1.00---------------------------------------
...........................................................................................................................................GCATCCTCCTCTCGGCGCC............................................................................... 191.000.00---------------------------------------------------------------------------------------------------------------------------------1.00--------------------------
............................................................................................................................................................................................CTCCAGCGCCGTCTTT................................. 1611.001.00---------------------------------1.00--------------------------------------------------------------------------------------------------------------------------
............................................................................................................................................................CCTGTCACTTTCTACAACA.............................................................. 191.000.00----1.00-------------------------------------------------------------------------------------------------------------------------------------------------------