ID: uc010sps.1_intron_22_0_chr12_56095201_r.3p
GENE: (2)
chr12:56095151-56095400-


(15)
B-CELL 		(2)
BRAIN 		(9)
BREAST 		(28)
CELL-LINE 		(2)
CERVIX 		(1)
FIBROBLAST 		(3)
HEART 		(1)
HELA 		(5)
LIVER 		(2)
OTHER 		(4)
SKIN 		(4)
UTERUS 		(1)
XRN.ip

Sense strand
AGAGTGAGACCTTGCTTCAAAAAAAAAAAAAAAGTAATACTTGGAGAGTGAAGCGGACAGGAAGTTCTTTGCAGATGAGATGGTGACACTTACAAAGGTCCAGGGACAGGGCCAAGCTTGGCATTTTGGAGGACTGTGACATGATCAGGGAGACACACATCCTATGTGGTGGCTTAATTGTGTCTTTTGGCTCCAGGCAGAATGTGGAACAAGGAGATCTCCATTTGAGGGCAAGGAAGTGGGTGCAGAC
................................................................................................(((((.....(((.((((....))))...)))..)))))..((((..((..(((..((.(((((...)))))))..))).))..))))..................................................................
............................................................................................93..........................................................................................185...............................................................
SizePerfect hitTotal NormPerfect NormSRR033718(GSM497063)
Multiple Myeloma (U266). (B cell)		SRR033722(GSM497067)
KMS12 cell line (KMS12). (B cell)		SRR039637(GSM518474)
THP1_total_sRNAs. (cell line)		SRR094131(GSM651907)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR033723(GSM497068)
L1236 cell line (L1236). (B cell)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		SRR033711(GSM497056)
GCB DLBCL (GCB110). (B cell)		SRR094129(GSM651905)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR033731(GSM497076)
h929 Cell line (h929). (B cell)		SRR039635(GSM518472)
THP1_nuc_sRNAs. (cell line)		SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)		SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR189775(GSM714635)
cell line: HEK293clip variant: CLIPenzymatic . (cell line)		SRR037876(GSM522374)
fibroblasts_cell_culture. (fibroblast)		SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)		SRR029124(GSM416753)
HeLa. (hela)		SRR189776(GSM714636)
cell line: HEK293clip variant: CLIPenzymatic . (cell line)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR189777(GSM714637)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		SRR094130(GSM651906)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR029132(GSM416761)
MB-MDA231. (cell line)		TAX577738(Rovira)
total RNA. (breast)		SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR029129(GSM416758)
SW480. (cell line)		SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)		SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		SRR015360(GSM380325)
Plasma B cells (PC137). (B cell)		TAX577743(Rovira)
total RNA. (breast)		SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR039616(GSM531979)
HBV(+) Distal Tissue Sample 1. (liver)		TAX577588(Rovira)
total RNA. (breast)		SRR015363(GSM380328)
Germinal Center B cell (GC40). (B cell)		SRR191607(GSM715717)
192genomic small RNA (size selected RNA from . (breast)		SRR060982(GSM569186)
Human centrocyte [09-001]. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		TAX577744(Rovira)
total RNA. (breast)		SRR039611(GSM531974)
Human Normal Liver Tissue Sample 1. (liver)		SRR444061(SRX128909)
Sample 19cDNABarcode: AF-PP-341: ACG CTC TTC . (skin)		SRR015359(GSM380324)
Germinal Center B cell (GC136). (B cell)		SRR060983(GSM569187)
Human pre-germinal center B cell [09-001]. (cell line)		SRR107297(GSM677704)
18-30nt fraction of small RNA. (cell line)		SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)		SRR191447(GSM715557)
142genomic small RNA (size selected RNA from . (breast)		SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)		SRR040028(GSM532913)
G026N. (cervix)		SRR330922(SRX091760)
tissue: normal skindisease state: normal. (skin)		SRR033724(GSM497069)
L428 cell line (L428). (B cell)		SRR039192(GSM494811)
K562 cell line is derived from a CML patient . (cell line)		SRR029128(GSM416757)
H520. (cell line)		SRR029127(GSM416756)
A549. (cell line)		SRR040022(GSM532907)
G575N. (cervix)		SRR033732(GSM497077)
bjab cell line (bjab103). (B cell)		SRR038859(GSM458542)
MM386. (cell line)		SRR029126(GSM416755)
143B. (cell line)		SRR029130(GSM416759)
DLD2. (cell line)		SRR191609(GSM715719)
194genomic small RNA (size selected RNA from . (breast)		SRR038857(GSM458540)
D20. (cell line)		SRR039613(GSM531976)
Human Normal Liver Tissue Sample 3. (liver)		SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR191582(GSM715692)
95genomic small RNA (size selected RNA from t. (breast)		SRR038853(GSM458536)
MELB. (cell line)		SRR342898(SRX096794)
small RNA seq of Right atrial tissue. (heart)		SRR015361(GSM380326)
Memory B cells (MM55). (B cell)		SRR330886(SRX091724)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039624(GSM531987)
HBV(-) HCV(-) Adjacent Tissue Sample. (liver)		SRR191486(GSM715596)
125genomic small RNA (size selected RNA from . (breast)		SRR330923(SRX091761)
tissue: normal skindisease state: normal. (skin)		SRR342896(SRX096792)
small RNA seq of Right atrial tissue. (heart)
...................................................................................................................................................................ATGTGGTGGCTTAATTTT.....................................................................18257.000.0073.0031.0024.007.0017.0011.008.003.00-8.007.008.00--6.005.004.00-5.00--2.00-3.00--3.003.001.001.003.002.001.00-----1.001.002.001.002.00---1.00-1.00-1.00--1.001.001.001.00-1.001.001.00--1.00---1.00----1.001.00--
...................................................................................................................................................................ATGTGGTGGCTTAATTT......................................................................1741.000.00---15.00---4.00-------------2.00--4.00----2.00--2.003.00---2.001.001.00-------1.00--------------1.00--1.00---1.001.00-----
...................................................................................................................................................................ATGTGGTGGCTTAATTTA.....................................................................1816.000.003.001.001.00--1.002.001.00-1.00-----1.00-------1.00----2.00--------------1.00------------------------1.00-------
...................................................................................................................................................................ATGTGGTGGCTTAATTTTT....................................................................196.000.005.00---------------1.00-----------------------------------------------------------
...................................................................................................................................................................ATGTGGTGGCTTAATTTAA....................................................................195.000.00--2.00-1.00-----1.00--------------------1.00--------------------------------------------
...................................................................................................................................................................ATGTGGTGGCTTAATTTTA....................................................................193.000.00-1.00----1.001.00--------------------------------------------------------------------
...................................................................................................................................................................................................................................AGGGCAAGGAAGTGGGCCT....192.000.00------------------------------------2.00---------------------------------------
...................................................................................................................................................................ATGTGGTGGCTTAATTTAAA...................................................................202.000.00-----------------------------------------1.00---------------1.00------------------
..........................................................................................................................................................................GGCTTAATTGTGTCTTTTGG............................................................2011.001.00--------------------------------------------1.00-------------------------------
...................................................................................................................................................................ATGTGGTGGCTTAATTTC.....................................................................181.000.00-------------------------------------------------------------1.00--------------
.................................................................................................................................................................................................CAGGCAGAATGTGGAACAAGGAGAT................................2511.001.00----------------------1.00-----------------------------------------------------
.................................................................................................GTCCAGGGACAGGGCCAA.......................................................................................................................................1811.001.00---------------------------------------------1.00------------------------------
........................................................................................................................................TGACATGATCAGGGAGACACACATC.........................................................................................2511.001.00-----------------------------------1.00----------------------------------------
.....................................................................................................................................................................................................CAGAATGTGGAACAAGGAGATCTC.............................2411.001.00-----------------------------------------------------------------------1.00----
...................................................................................................................................................................ATGTGGTGGCTTAATTTG.....................................................................181.000.00-1.00--------------------------------------------------------------------------
....................................................................................................................................................................................................................................GGGCAAGGAAGTGGGTCTGT..201.000.00-------------------------------------------------1.00--------------------------
...........................................................................................................................................................................................................................TCCATTTGAGGGCAAATCT............191.000.00----------------------------------------------------------------1.00-----------
...............................................................................................................................GGAGGACTGTGACATGATCAGGGAGACAC..............................................................................................2911.001.00-----------------------------------1.00----------------------------------------
............................................................................................................GGGCCAAGCTTGGCATTTTGGAGGACTGTGA...............................................................................................................3111.001.00--------------------1.00-------------------------------------------------------
..................................................AAGCGGACAGGAAGTTCTTTCT..................................................................................................................................................................................221.000.00--------1.00-------------------------------------------------------------------
..................................................................................................................................................................................................AGGCAGAATGTGGAACAAGGGGA.................................231.000.00----------------------1.00-----------------------------------------------------
.................................................................................................................................................................................................................................TGAGGGCAAGGAAGTGGGTGCA...2211.001.00---------------------------------------------------1.00------------------------
...........................................................................................................................................................................................................................TCCATTTGAGGGCAATTCT............191.000.00-------------------------------------------1.00--------------------------------
.........................................................................................TTACAAAGGTCCAGGGACA..............................................................................................................................................1911.001.00--------------------1.00-------------------------------------------------------
.........................................................................................................................................................................................TTTGGCTCCAGGCAGAATGTGGAACAA......................................2711.001.00------------------------------------------------------------------1.00---------
..............................................................................................................................TGGAGGACTGTGACATGATCAGGGAGA.................................................................................................2711.001.00--------------------1.00-------------------------------------------------------
..............CTTCAAAAAAAAAAAAATTTT.......................................................................................................................................................................................................................211.000.00----------------------------------------------------1.00-----------------------
................................................................................................................................................................................................CCAGGCAGAATGTGGAACAAGGAGA.................................2511.001.00----------------------1.00-----------------------------------------------------
.........................................TGGAGAGTGAAGCGGACAGG.............................................................................................................................................................................................2011.001.00--------------------1.00-------------------------------------------------------
...................................................................................................................................................................ATGTGGTGGCTTAATTTTG....................................................................191.000.001.00---------------------------------------------------------------------------
...........................................................................................................................................................................................................................TCCATTTGAGGGCAAG...............1630.330.33--------------------------------------------------------------------------0.33-
.............................................................................................................................TTGGAGGACTGTGAC..............................................................................................................1560.170.17---------------------------------------------------------------------------0.17

Antisense strand
AGAGTGAGACCTTGCTTCAAAAAAAAAAAAAAAGTAATACTTGGAGAGTGAAGCGGACAGGAAGTTCTTTGCAGATGAGATGGTGACACTTACAAAGGTCCAGGGACAGGGCCAAGCTTGGCATTTTGGAGGACTGTGACATGATCAGGGAGACACACATCCTATGTGGTGGCTTAATTGTGTCTTTTGGCTCCAGGCAGAATGTGGAACAAGGAGATCTCCATTTGAGGGCAAGGAAGTGGGTGCAGAC
................................................................................................(((((.....(((.((((....))))...)))..)))))..((((..((..(((..((.(((((...)))))))..))).))..))))..................................................................
............................................................................................93..........................................................................................185...............................................................
SizePerfect hitTotal NormPerfect NormSRR033718(GSM497063)
Multiple Myeloma (U266). (B cell)		SRR033722(GSM497067)
KMS12 cell line (KMS12). (B cell)		SRR039637(GSM518474)
THP1_total_sRNAs. (cell line)		SRR094131(GSM651907)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR033723(GSM497068)
L1236 cell line (L1236). (B cell)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		SRR033711(GSM497056)
GCB DLBCL (GCB110). (B cell)		SRR094129(GSM651905)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR033731(GSM497076)
h929 Cell line (h929). (B cell)		SRR039635(GSM518472)
THP1_nuc_sRNAs. (cell line)		SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)		SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR189775(GSM714635)
cell line: HEK293clip variant: CLIPenzymatic . (cell line)		SRR037876(GSM522374)
fibroblasts_cell_culture. (fibroblast)		SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)		SRR029124(GSM416753)
HeLa. (hela)		SRR189776(GSM714636)
cell line: HEK293clip variant: CLIPenzymatic . (cell line)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR189777(GSM714637)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		SRR094130(GSM651906)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR029132(GSM416761)
MB-MDA231. (cell line)		TAX577738(Rovira)
total RNA. (breast)		SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR029129(GSM416758)
SW480. (cell line)		SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)		SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		SRR015360(GSM380325)
Plasma B cells (PC137). (B cell)		TAX577743(Rovira)
total RNA. (breast)		SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR039616(GSM531979)
HBV(+) Distal Tissue Sample 1. (liver)		TAX577588(Rovira)
total RNA. (breast)		SRR015363(GSM380328)
Germinal Center B cell (GC40). (B cell)		SRR191607(GSM715717)
192genomic small RNA (size selected RNA from . (breast)		SRR060982(GSM569186)
Human centrocyte [09-001]. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		TAX577744(Rovira)
total RNA. (breast)		SRR039611(GSM531974)
Human Normal Liver Tissue Sample 1. (liver)		SRR444061(SRX128909)
Sample 19cDNABarcode: AF-PP-341: ACG CTC TTC . (skin)		SRR015359(GSM380324)
Germinal Center B cell (GC136). (B cell)		SRR060983(GSM569187)
Human pre-germinal center B cell [09-001]. (cell line)		SRR107297(GSM677704)
18-30nt fraction of small RNA. (cell line)		SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)		SRR191447(GSM715557)
142genomic small RNA (size selected RNA from . (breast)		SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)		SRR040028(GSM532913)
G026N. (cervix)		SRR330922(SRX091760)
tissue: normal skindisease state: normal. (skin)		SRR033724(GSM497069)
L428 cell line (L428). (B cell)		SRR039192(GSM494811)
K562 cell line is derived from a CML patient . (cell line)		SRR029128(GSM416757)
H520. (cell line)		SRR029127(GSM416756)
A549. (cell line)		SRR040022(GSM532907)
G575N. (cervix)		SRR033732(GSM497077)
bjab cell line (bjab103). (B cell)		SRR038859(GSM458542)
MM386. (cell line)		SRR029126(GSM416755)
143B. (cell line)		SRR029130(GSM416759)
DLD2. (cell line)		SRR191609(GSM715719)
194genomic small RNA (size selected RNA from . (breast)		SRR038857(GSM458540)
D20. (cell line)		SRR039613(GSM531976)
Human Normal Liver Tissue Sample 3. (liver)		SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR191582(GSM715692)
95genomic small RNA (size selected RNA from t. (breast)		SRR038853(GSM458536)
MELB. (cell line)		SRR342898(SRX096794)
small RNA seq of Right atrial tissue. (heart)		SRR015361(GSM380326)
Memory B cells (MM55). (B cell)		SRR330886(SRX091724)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039624(GSM531987)
HBV(-) HCV(-) Adjacent Tissue Sample. (liver)		SRR191486(GSM715596)
125genomic small RNA (size selected RNA from . (breast)		SRR330923(SRX091761)
tissue: normal skindisease state: normal. (skin)		SRR342896(SRX096792)
small RNA seq of Right atrial tissue. (heart)
..................AAAAAAAAAAAAAAAGTAATCTTC................................................................................................................................................................................................................ 242.000.00------------1.00---------------------1.00-----------------------------------------
..................AAAAAAAAAAAAAAAGTAATAACG................................................................................................................................................................................................................ 242.000.00-----------------1.00-1.00--------------------------------------------------------
....................AAAAAAAAAAAAAGTAATAAG................................................................................................................................................................................................................. 212.000.00-----------------1.00-------1.00--------------------------------------------------
.............GCTTCAAAAAAAAAAAAAGATG....................................................................................................................................................................................................................... 221.000.00--------1.00-------------------------------------------------------------------
.............GCTTCAAAAAAAAAAAAAACCCC...................................................................................................................................................................................................................... 231.000.00------------1.00---------------------------------------------------------------
....................AAAAAAAAAAAAAGTAATCCCG................................................................................................................................................................................................................ 221.000.00-------------------------1.00--------------------------------------------------
....................AAAAAAAAAAAAAGTAATCACC................................................................................................................................................................................................................ 221.000.00------------1.00---------------------------------------------------------------
................TCAAAAAAAAAAAAAAAGTTTGT................................................................................................................................................................................................................... 231.000.00----------------------1.00-----------------------------------------------------
...................AAAAAAAAAAAAAAGTAATAATT................................................................................................................................................................................................................ 231.000.00-------------------1.00--------------------------------------------------------
..............CTTCAAAAAAAAAAAAAAAGTGGG.................................................................................................................................................................................................................... 241.000.00--------1.00-------------------------------------------------------------------
....................AAAAAAAAAAAAAGTAATCGGG................................................................................................................................................................................................................ 221.000.00--------1.00-------------------------------------------------------------------
..............CTTCAAAAAAAAAAAAAAAGTGGAG................................................................................................................................................................................................................... 251.000.00--------1.00-------------------------------------------------------------------
.............GCTTCAAAAAAAAAAAAGTC......................................................................................................................................................................................................................... 201.000.00--------1.00-------------------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATACTCT............................................................................................................................................................................................................... 251.000.00-------------1.00--------------------------------------------------------------
...................AAAAAAAAAAAAAAGTAATAAACG............................................................................................................................................................................................................... 241.000.00-------------1.00--------------------------------------------------------------
......................AAAAAAAAAAAGTAATAAATG............................................................................................................................................................................................................... 211.000.00-------------1.00--------------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATAATTA............................................................................................................................................................................................................... 251.000.00-------------1.00--------------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATACGAG............................................................................................................................................................................................................... 251.000.00--------1.00-------------------------------------------------------------------
....................AAAAAAAAAAAAAGTAATCAAT................................................................................................................................................................................................................ 221.000.00-------------------1.00--------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATAATG................................................................................................................................................................................................................ 241.000.00-----------------1.00----------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATACTTG............................................................................................................................................................................................................... 251.000.00-------------1.00--------------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATCCAG................................................................................................................................................................................................................ 241.000.00----------------------------------1.00-----------------------------------------
....................AAAAAAAAAAAAAGTAATCCAG................................................................................................................................................................................................................ 221.000.00-----------------1.00----------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATAATAT............................................................................................................................................................................................................... 251.000.00-------------------1.00--------------------------------------------------------
..................AAAAAAAAAAAAAAAGTAATCTTG................................................................................................................................................................................................................ 241.000.00-------------------------1.00--------------------------------------------------
..............CTTCAAAAAAAAAAAAAAAGTGGGG................................................................................................................................................................................................................... 251.000.00------------1.00---------------------------------------------------------------
....................AAAAAAAAAAAAAGTAATAAATC............................................................................................................................................................................................................... 231.000.00-------------------------1.00--------------------------------------------------
.............GCTTCAAAAAAAAAAAAAAAGTGG..................................................................................................................................................................................................................... 241.000.00------------1.00---------------------------------------------------------------
...............TTCAAAAAAAAAAAAAAAGTAATTTG................................................................................................................................................................................................................. 261.000.00-------------------1.00--------------------------------------------------------
...................AAAAAAAAAAAAAAGTAATAATA................................................................................................................................................................................................................ 231.000.00-------------1.00--------------------------------------------------------------
....................AAAAAAAAAAAAAGTAATCAC................................................................................................................................................................................................................. 211.000.00------------1.00---------------------------------------------------------------
................TCAAAAAAAAAAAAAAAGTAATTTGG................................................................................................................................................................................................................ 261.000.00--------1.00-------------------------------------------------------------------
.....................AAAAAAAAAAAAGTAATACAAG............................................................................................................................................................................................................... 221.000.00------------1.00---------------------------------------------------------------
....................AAAAAAAAAAAAAGTAATAATTT............................................................................................................................................................................................................... 231.000.00----------------------------------1.00-----------------------------------------
....................AAAAAAAAAAAAAGTAATAATTA............................................................................................................................................................................................................... 231.000.00-----------------1.00----------------------------------------------------------
....................AAAAAAAAAAAAAGTAATAGGG................................................................................................................................................................................................................ 221.000.00--------1.00-------------------------------------------------------------------