| (1) AGO2.ip | (1) BRAIN | (4) BREAST | (8) CELL-LINE | (1) CERVIX | (1) FIBROBLAST | (2) HEART | (2) HELA | (4) LIVER | (3) OTHER | (7) SKIN | (1) TESTES | (3) UTERUS | (2) XRN.ip |
| ACAGAACTGTGTGTATGAGGTACAGCAGGTACCAAAAGTAGAAAAGACAGGTAAGTGTTTGTAATACATTTTGGCAGTCTGCTGGGTAATCATGTTCCCTTTGAAGACATAAAACTAAGTTTTTAAAAAGAAAAAATCTCAGGGATGAATATTCATATATATAAATATGTAGTTATTCATTTTTTTTCTTAAGACCTCTAAATTTACCTTTTTAAAGTTGAACTTCCAGAATTATCTGTGCATGATTTACTTGCATGTTGCTTTGGAATTGTTTGCATTTTTCTATTTTTCCTAATTCTGGAGGCCATCGAAATATATAGATTCCAGAATGAAACATGTAACTAGGCATCTTTCTAACCTAGATAAGTCTTAAATATTGTTTCTAGAGTAAGATGACGATATTAAGGCAAACTAGAACAATAACATTAATATATTTTCCTCTATTCTTACAGACAGTGATCTGACACAAACACAGCTGAAGCAAACAGAGGTCCTAGTGACA ...............................................................................................................................................(((((.....(((((......)))))...)))))..................................................................................................................................................................................................................................................................................................................................... ...............................................................................................................................128..............................................177................................................................................................................................................................................................................................................................................................................................... | Size | Perfect hit | Total Norm | Perfect Norm | SRR189782 | SRR094129(GSM651905) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR094130(GSM651906) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR189784 | SRR094131(GSM651907) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR037937(GSM510475) 293cand2. (cell line) | SRR330904(SRX091742) tissue: normal skindisease state: normal. (skin) | SRR207115(GSM721077) XRN1&2 knockdown. (XRN1/XRN2 cell line) | SRR330915(SRX091753) tissue: normal skindisease state: normal. (skin) | SRR039623(GSM531986) HCV(+) HCC Tissue Sample. (liver) | DRR001487(DRX001041) "Hela long nuclear cell fraction, LNA(+)". (hela) | RoviraIPAgo2(Rovira) total RNA. (ago2 breast) | SRR330889(SRX091727) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR029124(GSM416753) HeLa. (hela) | SRR039620(GSM531983) HBV(+) Adjacent Tissue Sample 2. (liver) | SRR342894(SRX096790) small RNA seq of Right atrial tissue. (heart) | SRR189787 | GSM450601(GSM450601) miRNA sequencing raw reads from post-mortem s. (brain) | SRR191607(GSM715717) 192genomic small RNA (size selected RNA from . (breast) | SRR040011(GSM532896) G529T. (cervix) | SRR039618(GSM531981) HBV(+) Side Tissue Sample 1. (liver) | SRR342901(SRX096797) small RNA seq of Left atrial tissue. (heart) | SRR037943(GSM510481) 293DcrTN. (cell line) | SRR330923(SRX091761) tissue: normal skindisease state: normal. (skin) | SRR037876(GSM522374) fibroblasts_cell_culture. (fibroblast) | SRR191616(GSM715726) 103genomic small RNA (size selected RNA from . (breast) | SRR330896(SRX091734) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR189780(GSM714640) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR553576(SRX182782) source: Testis. (testes) | SRR039622(GSM531985) HCV(+) Adjacent Tissue Sample. (liver) | SRR207116(GSM721078) Nuclear RNA. (cell line) | SRR207119(GSM721081) XRN1&2 knockdown. (XRN1/XRN2 cell line) | TAX577743(Rovira) total RNA. (breast) | SRR189777(GSM714637) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR189781(GSM714641) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330867(SRX091705) tissue: skin psoriatic involveddisease state:. (skin) | SRR330919(SRX091757) tissue: normal skindisease state: normal. (skin) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ...........................................................................................................................................................TATATATAAATATGTACG......................................................................................................................................................................................................................................................................................................................................... | 18 | 33.00 | 0.00 | 33.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ........................................................................................................................................................................................................................................................................................................................................................................................................ATGACGATATTAAGGCAAACTAGAACAATAACATTAATATATTTTCCTCTATTCTTACAG.................................................. | 60 | 1 | 2.00 | 2.00 | - | - | - | - | - | - | - | - | - | - | 2.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ....................................................................................................................................AAAATCTCAGGGATGTCCA............................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..AGAACTGTGTGTATGAGGTA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ | 20 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ..........................................................................................................................................................................................................................................................................................................................................................................................................................ACTAGAACAATAACAATGA......................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ......................................................................TTGGCAGTCTGCTGGGT............................................................................................................................................................................................................................................................................................................................................................................................................................... | 17 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .............................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGACACAAACACAGCTGAAGCAAACAG.............. | 27 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .....................................GTAGAAAAGACAGGTAAGTGTTT.......................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 23 | 1 | 1.00 | 1.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ......................................................................................................................................AATCTCAGGGATGAATAT.............................................................................................................................................................................................................................................................................................................................................................. | 18 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - |
| ...................................................................................................................................................AATATTCATATATATAAATATA............................................................................................................................................................................................................................................................................................................................................. | 22 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | |
| .......................................................................................................................................................................................................................................................................................................................................................................................................................................................................GTGATCTGACACAAACACAGCTGAAGC.................... | 27 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ATCTGACACAAACACAGCTGAAGCAAAAAAA............. | 31 | 1.00 | 0.00 | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................................................................ATATGTAGTTATTCAATTG............................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .....................................GTAGAAAAGACAGGTAAGTGTA........................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 22 | 1.00 | 0.00 | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................................................................TATATATAAATATGTACGTA....................................................................................................................................................................................................................................................................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................TCTGACACAAACACAGCTGAAGCAAAC................ | 27 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - |
| ......................................................................................................................................................................................................................................................................................................................................................................................................AGATGACGATATTAAGGCAAACTAG....................................................................................... | 25 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...........................................................................................................................................................TATATATAAATATGTACGAA....................................................................................................................................................................................................................................................................................................................................... | 20 | 1.00 | 0.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ................................................................................................................................................................................................................................................................................................................................................................................................................ATTAAGGCAAACTAGAACAATAACATTA.......................................................................... | 28 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ............................................................................GTCTGCTGGGTAATCGG......................................................................................................................................................................................................................................................................................................................................................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | |
| .......TGTGTGTATGAGGTACAGCAGGTACCAAAAGTAGA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ | 35 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CTGAAGCAAACAGAGGT.......... | 17 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - |
| .................AGGTACAGCAGGTACCAAAAGTAGA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ | 25 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - |
| .........................................................................................................................................................................................................................................................................................................................................................................................................TGACGATATTAAGGCAAACTAGA...................................................................................... | 23 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .........................................................................................................................................................................................................................................................................................................CTGGAGGCCATCGAAAT............................................................................................................................................................................................ | 17 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...............................................................................................................................AAGAAAAAATCTCAGGAAC.................................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | |
| .........................................................................................................................................................................................................................................................................................................................................................................................................TGACGATATTAAGGCAAACTAG....................................................................................... | 22 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...........................................................................................................................................................TATATATAAATATGTAGGTGT...................................................................................................................................................................................................................................................................................................................................... | 21 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................TCTGACACAAACACAGCTGAAGCAA.................. | 25 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...........................................................................................................................................................TATATATAAATATGTACGT........................................................................................................................................................................................................................................................................................................................................ | 19 | 1.00 | 0.00 | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGACACAAACACAGCTGAAG..................... | 20 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .....................................................................................................................................................................................................................................................................................................................................................................................................................................AACATTAATATATTTTCC............................................................... | 18 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - |
| ACAGAACTGTGTGTATGAGGTACAGCAGGTACCAAAAGTAGAAAAGACAGGTAAGTGTTTGTAATACATTTTGGCAGTCTGCTGGGTAATCATGTTCCCTTTGAAGACATAAAACTAAGTTTTTAAAAAGAAAAAATCTCAGGGATGAATATTCATATATATAAATATGTAGTTATTCATTTTTTTTCTTAAGACCTCTAAATTTACCTTTTTAAAGTTGAACTTCCAGAATTATCTGTGCATGATTTACTTGCATGTTGCTTTGGAATTGTTTGCATTTTTCTATTTTTCCTAATTCTGGAGGCCATCGAAATATATAGATTCCAGAATGAAACATGTAACTAGGCATCTTTCTAACCTAGATAAGTCTTAAATATTGTTTCTAGAGTAAGATGACGATATTAAGGCAAACTAGAACAATAACATTAATATATTTTCCTCTATTCTTACAGACAGTGATCTGACACAAACACAGCTGAAGCAAACAGAGGTCCTAGTGACA ...............................................................................................................................................(((((.....(((((......)))))...)))))..................................................................................................................................................................................................................................................................................................................................... ...............................................................................................................................128..............................................177................................................................................................................................................................................................................................................................................................................................... | Size | Perfect hit | Total Norm | Perfect Norm | SRR189782 | SRR094129(GSM651905) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR094130(GSM651906) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR189784 | SRR094131(GSM651907) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR037937(GSM510475) 293cand2. (cell line) | SRR330904(SRX091742) tissue: normal skindisease state: normal. (skin) | SRR207115(GSM721077) XRN1&2 knockdown. (XRN1/XRN2 cell line) | SRR330915(SRX091753) tissue: normal skindisease state: normal. (skin) | SRR039623(GSM531986) HCV(+) HCC Tissue Sample. (liver) | DRR001487(DRX001041) "Hela long nuclear cell fraction, LNA(+)". (hela) | RoviraIPAgo2(Rovira) total RNA. (ago2 breast) | SRR330889(SRX091727) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR029124(GSM416753) HeLa. (hela) | SRR039620(GSM531983) HBV(+) Adjacent Tissue Sample 2. (liver) | SRR342894(SRX096790) small RNA seq of Right atrial tissue. (heart) | SRR189787 | GSM450601(GSM450601) miRNA sequencing raw reads from post-mortem s. (brain) | SRR191607(GSM715717) 192genomic small RNA (size selected RNA from . (breast) | SRR040011(GSM532896) G529T. (cervix) | SRR039618(GSM531981) HBV(+) Side Tissue Sample 1. (liver) | SRR342901(SRX096797) small RNA seq of Left atrial tissue. (heart) | SRR037943(GSM510481) 293DcrTN. (cell line) | SRR330923(SRX091761) tissue: normal skindisease state: normal. (skin) | SRR037876(GSM522374) fibroblasts_cell_culture. (fibroblast) | SRR191616(GSM715726) 103genomic small RNA (size selected RNA from . (breast) | SRR330896(SRX091734) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR189780(GSM714640) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR553576(SRX182782) source: Testis. (testes) | SRR039622(GSM531985) HCV(+) Adjacent Tissue Sample. (liver) | SRR207116(GSM721078) Nuclear RNA. (cell line) | SRR207119(GSM721081) XRN1&2 knockdown. (XRN1/XRN2 cell line) | TAX577743(Rovira) total RNA. (breast) | SRR189777(GSM714637) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR189781(GSM714641) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330867(SRX091705) tissue: skin psoriatic involveddisease state:. (skin) | SRR330919(SRX091757) tissue: normal skindisease state: normal. (skin) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ..................................................................................................................................AAAAAATCTCAGGGAAACC................................................................................................................................................................................................................................................................................................................................................................. | 19 | 14.00 | 0.00 | - | 10.00 | 3.00 | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ................................................AGGTAAGTGTTTGTAATCAG.................................................................................................................................................................................................................................................................................................................................................................................................................................................. | 20 | 3.00 | 0.00 | - | - | - | 3.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................AAAAAATCTCAGGGAAAC.................................................................................................................................................................................................................................................................................................................................................................. | 18 | 2.00 | 0.00 | - | 1.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................................GAATATTCATATATATCCTG................................................................................................................................................................................................................................................................................................................................................ | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | |
| .........................................................................................................................................................................................................................................................................................................................................................................................................................................TTAATATATTTTCCTCATG.......................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................................................CAGGGATGAATATTCTAGC........................................................................................................................................................................................................................................................................................................................................................ | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................................GAATATTCATATATATCATA................................................................................................................................................................................................................................................................................................................................................ | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...............................................................................................................................................GATGAATATTCATATATCA.................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | |
| ........................................................................................................................................................................................................................................................................................................................................................................................................................................................CTATTCTTACAGACATTTC........................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................................................CAGGGATGAATATTCCAGC........................................................................................................................................................................................................................................................................................................................................................ | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................................................................................................GAAACATGTAACTAGTAGA......................................................................................................................................................... | 19 | 1.00 | 0.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |