ID: uc003ddk.2_intron_3_0_chr3_52293889_r.5p
GENE: WDR82(3)
chr3:52294201-52294450-


(2)
B-CELL
(4)
BRAIN
(4)
BREAST
(11)
CELL-LINE
(4)
CERVIX
(1)
HEART
(1)
HELA
(2)
LIVER
(2)
OTHER
(7)
SKIN
(1)
TESTES
(2)
XRN.ip

Sense strand
GTGTCAACTCTGAAATGGTCAAGCTTTATGACCTTCGTTCTTTTGATAAGGTAAATCTTTGAATCTTTGAGATCTTTGAGCTGTTTTTTGTTTTGTTTTGTTTTTGAGACAGAGTTTTGCTCTTATTGCCCAGGCTGGAGTGCAGTGGTGTAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACACGTGTCCGCCACCACGCCTG
.............................................................................((((....((((((((((.........))))))))))....))))...(((((((.((......))..))).)))).................................................................................................
............................................................................77..........................................................................153...............................................................................................
SizePerfect hitTotal NormPerfect NormSRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR553573(SRX182779)
source: Cerebellum. (Cerebellum)
SRR040028(GSM532913)
G026N. (cervix)
SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR040034(GSM532919)
G001N. (cervix)
SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)
SRR033712(GSM497057)
Burkitt Lymphoma (BL510). (B cell)
SRR039621(GSM531984)
HBV(+) HCC Tissue Sample 2. (liver)
SRR330873(SRX091711)
tissue: skin psoriatic involveddisease state:. (skin)
SRR330908(SRX091746)
tissue: normal skindisease state: normal. (skin)
DRR000555(DRX000313)
"THP-1 whole cell RNA, no treatment". (cell line)
TAX577588(Rovira)
total RNA. (breast)
SRR040010(GSM532895)
G529N. (cervix)
TAX577746(Rovira)
total RNA. (breast)
GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)
DRR000557(DRX000315)
"THP-1 whole cell RNA, after 3 day treatment . (cell line)
SRR343336SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)
DRR000558(DRX000316)
"THP-1 whole cell RNA, after 3 day treatment . (cell line)
SRR189782TAX577740(Rovira)
total RNA. (breast)
SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)
SRR330884(SRX091722)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR330861(SRX091699)
tissue: skin psoriatic involveddisease state:. (skin)
TAX577742(Rovira)
total RNA. (breast)
DRR000559(DRX000317)
"THP-1 whole cell RNA, no treatment". (cell line)
GSM450608(GSM450608)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR553576(SRX182782)
source: Testis. (testes)
SRR330902(SRX091740)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR326282(GSM769512)
"Dicer mRNA was knocked down using siDicer, t. (cell line)
GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM450605(GSM450605)
miRNA sequencing raw reads from post-mortem s. (brain)
DRR001485(DRX001039)
"Hela long total cell fraction, LNA(+)". (hela)
SRR040035(GSM532920)
G001T. (cervix)
SRR342896(SRX096792)
small RNA seq of Right atrial tissue. (heart)
SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)
SRR207119(GSM721081)
XRN1&2 knockdown. (XRN1/XRN2 cell line)
SRR330887(SRX091725)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)
SRR330868(SRX091706)
tissue: skin psoriatic involveddisease state:. (skin)
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTGAG................................................................................................................................................28152.000.0084.0068.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTG..................................................................................................................................................2628.000.0016.0012.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTGA.................................................................................................................................................276.000.005.001.00---------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTTTATC................................................................................................................................................253.000.003.00----------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTCGAG................................................................................................................................................283.000.002.001.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTCCTG......................................................................................................................................................222.000.00-2.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTGAGA...............................................................................................................................................292.000.002.00----------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTTCTTG...............................................................................................................................................272.000.001.00---1.00------------------------------------
............................................................................................................................ATTGCCCAGGCTGGAGTGCAGTGCGCT...................................................................................................272.000.00-2.00---------------------------------------
.........CTGAAATGGTCAAGCTTT...............................................................................................................................................................................................................................1812.002.00---2.00-------------------------------------
............................................................................................................................ATTGCCCAGGCTGGAGTGCAGTGCGT....................................................................................................262.000.00-2.00---------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTTTTCACC..............................................................................................................................................272.000.002.00----------------------------------------
............................................................................................................................ATTGCCCAGGCTGGAGTGCAGTCGC.....................................................................................................252.000.002.00----------------------------------------
..................................................................................................................................................................................................................................TACACGTGTCCGCCACCACGCCGGC251.000.001.00----------------------------------------
...........................................................................................................................................GTGCAGTGGTGTAATCTCAGAA.........................................................................................221.000.00----------------------1.00------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTTCGC................................................................................................................................................261.000.001.00----------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTCGAG................................................................................................................................................261.000.00----1.00------------------------------------
.......................................................................................................................................................................................................................GTAGCTGGGATTACACG..................1701.001.00-------------------1.00---------------------
.............AATGGTCAAGCTTTATTTT..........................................................................................................................................................................................................................191.000.00----1.00------------------------------------
...................................................................................TTTTTTGTTTTGTTTTGTTGCTG................................................................................................................................................231.000.00-1.00---------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTCTGA.................................................................................................................................................241.000.00-1.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTGAG.....................................................................................................................................................231.000.001.00----------------------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGGTCC..............................................................311.000.001.00----------------------------------------
...................................................................................TTTTTTGTTTTGTTTTGTTTTTGAGTCTG..........................................................................................................................................291.000.001.00----------------------------------------
...TCAACTCTGAAATGGTCAAGCTTTATGACC.........................................................................................................................................................................................................................3011.001.00----------------------------1.00------------
....CAACTCTGAAATGGTCAAGCTTT...............................................................................................................................................................................................................................2311.001.00-------------------------1.00---------------
..........................................................................................................................TTATTGCCCAGGCTGGAGTGCAGTCGTA....................................................................................................281.000.001.00----------------------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGGG................................................................291.000.001.00----------------------------------------
...........................................................................................................................TATTGCCCAGGCTGGAGTGCAGTGCGCG...................................................................................................281.000.00-1.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTCGTG................................................................................................................................................281.000.001.00----------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTCCTT.................................................................................................................................................241.000.00-1.00---------------------------------------
..........................................................................................................................TTATTGCCCAGGCTGGAGGGTT..........................................................................................................221.000.00---------------------1.00-------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTTTTCCTC..............................................................................................................................................271.000.001.00----------------------------------------
..GTCAACTCTGAAATGGTCAAGCT.................................................................................................................................................................................................................................2311.001.00-------1.00---------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTCCTT......................................................................................................................................................221.000.00-1.00---------------------------------------
..................................................................................................................................................................ACTGCAACCTCTGCCTCCCAGGTCCG..............................................................261.000.001.00----------------------------------------
...............................................................................GCTGTTTTTTGTTTTGTTTTGTTTTGCG...............................................................................................................................................281.000.001.00----------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTTCGAG..............................................................................................................................................301.000.001.00----------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTCGTT....................................................................................................................................................241.000.00-1.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTCGTT.........................................................................................................................................................191.000.001.00----------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTTTTCTTC..............................................................................................................................................271.000.001.00----------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTTTTGTTC.............................................................................................................................................291.000.001.00----------------------------------------
......................GCTTTATGACCTTCGTTCTTTTGATAAGTGGC....................................................................................................................................................................................................321.000.00------1.00----------------------------------
.......................................................................................TTGTTTTGTTTTGTTTTTGAGCGGG..........................................................................................................................................251.000.00-1.00---------------------------------------
.......................................................................................................................................................................................GTTCAAGTGATTCTCCTGCCTAAAA..........................................251.000.00--------------------------1.00--------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGGGT...............................................................301.000.001.00----------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTTTTCGAG..............................................................................................................................................271.000.001.00----------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTGAA................................................................................................................................................281.000.00-1.00---------------------------------------
...........................................................................................................................TATTGCCCAGGCTGGAGTGCAGTGCGC....................................................................................................271.000.001.00----------------------------------------
..................................................................................................................................................................ACTGCAACCTCTGCCTCCCAGGTCCGG.............................................................271.000.001.00----------------------------------------
...............................................................................GCTGTTTTTTGTTTTGTTC........................................................................................................................................................191.000.00-1.00---------------------------------------
......................................................................................................TTTGAGACAGAGTTTTGCTCCGCC............................................................................................................................241.000.001.00----------------------------------------
...............................................................................GCTGTTTTTTGTTTTGTTTTGTTTGAG................................................................................................................................................271.000.001.00----------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTCG..................................................................................................................................................261.000.001.00----------------------------------------
......................................................................................................................................................................................................................AGTAGCTGGGATTACACGATA...............211.000.00--------1.00--------------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGGCCA..............................................................311.000.00-1.00---------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTTCG.................................................................................................................................................251.000.001.00----------------------------------------
..................................................................................GTTTTTTGTTTTGTTTTGTTGCTG................................................................................................................................................241.000.00-1.00---------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTTCGTG...............................................................................................................................................271.000.001.00----------------------------------------
.TGTCAACTCTGAAATGGTCAAGCTT................................................................................................................................................................................................................................2511.001.00--------------------------------1.00--------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTTC.................................................................................................................................................271.000.001.00----------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTTTGAC................................................................................................................................................281.000.00-1.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGC.....................................................................................................................................................231.000.001.00----------------------------------------
............................................................................................................................ATTGCCCAGGCTGGAGTGCAGTGCGCG...................................................................................................271.000.001.00----------------------------------------
..........................................................................................................................................AGTGCAGTGGTGTAATCTCAGCTAC.......................................................................................251.000.00--1.00--------------------------------------
.....AACTCTGAAATGGTCAAGC..................................................................................................................................................................................................................................1911.001.00---------1.00-------------------------------
.........................................................................................................................................GAGTGCAGTGGTGTAAGGCC.............................................................................................201.000.00---1.00-------------------------------------
.................................................................................TGTTTTTTGTTTTGTTTTGTCGT..................................................................................................................................................231.000.001.00----------------------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGTCGGG.............................................................321.000.00-1.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTCTT..................................................................................................................................................261.000.001.00----------------------------------------
..........................................................................................................................................................................................CAAGTGATTCTCCTGCCTAAAA..........................................221.000.00-------------1.00---------------------------
...........................................................................................................................TATTGCCCAGGCTGGAGTGCAGTGCGCT...................................................................................................281.000.00-1.00---------------------------------------
..............................................................................AGCTGTTTTTTGTTTTGTTTTGTCTG..................................................................................................................................................261.000.001.00----------------------------------------
............................................................................................................................ATTGCCCAGGCTGGAGTGCAGCGTC.....................................................................................................251.000.001.00----------------------------------------
..................................................................................GTTTTTTGTTTTGTTTTGTTTTCCGC..............................................................................................................................................261.000.001.00----------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTCG.....................................................................................................................................................211.000.001.00----------------------------------------
................................................................................CTGTTTTTTGTTTTGTTTTGTTGGA.................................................................................................................................................251.000.001.00----------------------------------------
............................................................................................................................ATTGCCCAGGCTGGAGTGCAGCGCG.....................................................................................................251.000.001.00----------------------------------------
............................TGACCTTCGTTCTTTTGA............................................................................................................................................................................................................1820.500.50--0.50--------------------------------------
................................CTTCGTTCTTTTGATAAG........................................................................................................................................................................................................1820.500.50----------------------------------------0.50
.TGTCAACTCTGAAATGGT.......................................................................................................................................................................................................................................1820.500.50---------------------------------------0.50-
........TCTGAAATGGTCAAGC..................................................................................................................................................................................................................................1620.500.50--------------------------------------0.50--
..........................................................................................................................TTATTGCCCAGGCTGGAGTGCAGTGGTGTA..................................................................................................3040.250.250.25----------------------------------------

Antisense strand
GTGTCAACTCTGAAATGGTCAAGCTTTATGACCTTCGTTCTTTTGATAAGGTAAATCTTTGAATCTTTGAGATCTTTGAGCTGTTTTTTGTTTTGTTTTGTTTTTGAGACAGAGTTTTGCTCTTATTGCCCAGGCTGGAGTGCAGTGGTGTAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACACGTGTCCGCCACCACGCCTG
.............................................................................((((....((((((((((.........))))))))))....))))...(((((((.((......))..))).)))).................................................................................................
............................................................................77..........................................................................153...............................................................................................
SizePerfect hitTotal NormPerfect NormSRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR553573(SRX182779)
source: Cerebellum. (Cerebellum)
SRR040028(GSM532913)
G026N. (cervix)
SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR040034(GSM532919)
G001N. (cervix)
SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)
SRR033712(GSM497057)
Burkitt Lymphoma (BL510). (B cell)
SRR039621(GSM531984)
HBV(+) HCC Tissue Sample 2. (liver)
SRR330873(SRX091711)
tissue: skin psoriatic involveddisease state:. (skin)
SRR330908(SRX091746)
tissue: normal skindisease state: normal. (skin)
DRR000555(DRX000313)
"THP-1 whole cell RNA, no treatment". (cell line)
TAX577588(Rovira)
total RNA. (breast)
SRR040010(GSM532895)
G529N. (cervix)
TAX577746(Rovira)
total RNA. (breast)
GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)
DRR000557(DRX000315)
"THP-1 whole cell RNA, after 3 day treatment . (cell line)
SRR343336SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)
DRR000558(DRX000316)
"THP-1 whole cell RNA, after 3 day treatment . (cell line)
SRR189782TAX577740(Rovira)
total RNA. (breast)
SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)
SRR330884(SRX091722)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR330861(SRX091699)
tissue: skin psoriatic involveddisease state:. (skin)
TAX577742(Rovira)
total RNA. (breast)
DRR000559(DRX000317)
"THP-1 whole cell RNA, no treatment". (cell line)
GSM450608(GSM450608)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR553576(SRX182782)
source: Testis. (testes)
SRR330902(SRX091740)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR326282(GSM769512)
"Dicer mRNA was knocked down using siDicer, t. (cell line)
GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM450605(GSM450605)
miRNA sequencing raw reads from post-mortem s. (brain)
DRR001485(DRX001039)
"Hela long total cell fraction, LNA(+)". (hela)
SRR040035(GSM532920)
G001T. (cervix)
SRR342896(SRX096792)
small RNA seq of Right atrial tissue. (heart)
SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)
SRR207119(GSM721081)
XRN1&2 knockdown. (XRN1/XRN2 cell line)
SRR330887(SRX091725)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)
SRR330868(SRX091706)
tissue: skin psoriatic involveddisease state:. (skin)
....................................................................................................................................GGCTGGAGTGCAGTGGTGTGGCG............................................................................................... 232.000.002.00----------------------------------------
..................................................................................................................................................................................................................CCCAAGTAGCTGGGATTACACCGG................ 242.000.00-----2.00-----------------------------------
......................................................................................................................GCTCTTATTGCCCAGTCTG................................................................................................................. 192.000.00------------------------1.00----1.00-----------
......................................................................................................................................................................CAACCTCTGCCTCCCAGGTTCAAGTGATACG..................................................... 311.000.00-1.00---------------------------------------
...............................................................................................................................................................................CCTCCCAGGTTCAAGTGAGG....................................................... 201.000.00----------------1.00------------------------
....................................................................................................................................GGCTGGAGTGCAGTGGTGTAAGGAC............................................................................................. 251.000.001.00----------------------------------------
...............................................................................................................................................................CTCACTGCAACCTCTGCCTCCCAGGTTCAAGAAAG........................................................ 351.000.00-------------------------------------1.00---
....................................................................................................................................GGCTGGAGTGCAGTGGTGTAAGGCC............................................................................................. 251.000.001.00----------------------------------------
..............................................................................................................................................................................................................................GGATTACACGTGTCCTGTC......... 191.000.00-----------------1.00-----------------------
........................................................................................................................................................................ACCTCTGCCTCCCAGGTTCAAGTGATTCGCC................................................... 311.000.001.00----------------------------------------
......................................................................................................................................................................CAACCTCTGCCTCCCAGGTTCAAGTGCG........................................................ 281.000.00-------------------------------1.00---------
..................................................................................................................................................................................CCCAGGTTCAAGTGATTCTCCCTT................................................ 241.000.00------1.00----------------------------------
....................................................................................................................................GGCTGGAGTGCAGTGGTGTGGCC............................................................................................... 231.000.001.00----------------------------------------
...................................................................................................................................AGGCTGGAGTGCAGTGGTGTAATCGAC............................................................................................ 271.000.00-1.00---------------------------------------
...............................................................................................................................................................................CCTCCCAGGTTCAAGTGATTCTCCTGCCGCGG........................................... 321.000.00------------1.00----------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGTTTGCG............................................................ 331.000.001.00----------------------------------------
..........................................................................................................................................................................CTCTGCCTCCCAGGTTCAAGTGACG....................................................... 251.000.00-1.00---------------------------------------
..............................................................................................................................................................................................................................GGATTACACGTGTCCTG........... 171.000.00-----------------------1.00-----------------
..................................................................................................................................................................................CCCAGGTTCAAGTGATTCTCCTCGAA.............................................. 261.000.00---------------1.00-------------------------
........................................................................................................................................................................ACCTCTGCCTCCCAGGTTCAAGTGATCGCC.................................................... 301.000.001.00----------------------------------------
...........................................................................................................................................................................TCTGCCTCCCAGGTTCAAGTGATTCTCCAAAA............................................... 321.000.00---------------------------------1.00-------
..............................................................................................................................................................................................................................GGATTACACGTGTCCGGC.......... 181.000.00----------1.00------------------------------
.............................................................................................................................................................................TGCCTCCCAGGTTCAAGTGATTCTCCTAAA............................................... 301.000.00------------------------------1.00----------
...................................................................................................................................................................................................................CCAAGTAGCTGGGATTACCTCT................. 221.000.00----------------------------------1.00------
...........................................................................................................GACAGAGTTTTGCTCTTACGGG......................................................................................................................... 221.000.00-1.00---------------------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCG..................................................................... 241.000.00-1.00---------------------------------------
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGTCTG.............................................................. 311.000.00--1.00--------------------------------------
............................................................................................................................................TGCAGTGGTGTAATCTCAGAA......................................................................................... 211.000.00---------------------------1.00-------------
..................................................................................................................................................................................CCCAGGTTCAAGTGATTCTCTAA................................................. 231.000.00------------------1.00----------------------
.............................................................................................................................................................................TGCCTCCCAGGTTCAAGTGATTCTCCTT................................................. 281.000.00-----------------------------------1.00-----
............................................................................................................................ATTGCCCAGGCTGGAGTGTTAG........................................................................................................ 221.000.00--------------1.00--------------------------
.............................................................AATCTTTGAGATCTTTATTG......................................................................................................................................................................... 201.000.00--------------------1.00--------------------
.......................................................................ATCTTTGAGCTGTTTTAG................................................................................................................................................................. 181.000.00------------------------------------1.00----
.............................................................................................................................................................AGCTCACTGCAACCTCTGCCTCCCAGGCTG............................................................... 301.000.00--1.00--------------------------------------
...............................................................................................................................................................................CCTCCCAGGTTCAAGTGAAG....................................................... 201.000.00-----------1.00-----------------------------