| (1) AGO2.ip | (2) B-CELL | (2) BRAIN | (4) BREAST | (8) CELL-LINE | (7) HEART | (1) LIVER | (1) OTHER | (16) SKIN | (1) UTERUS |
| CCCAATGCTCTGAACTCTTCCCGCCTCCCGGAGCTCAGCCCTTGAGAAAGGCAGGCTTATATTTCCCTTAGTGACACTCATTTATCTTACAGCTCACCCCTTCTCATTTCTAAAGTATCCAGCAAGAATAGCAGGAAAAATTAGCTAAAGGCACCTAATGAATAAGCCTGCCTTTGCTCCAGAAATAATCGACAGATATCAAAGTGCGGAATAATTACAAGTAAACTTTCTCAACCAGTTTTTAACTACAACAATACATGTTGTGAATGAATATATTTGATAAAAATGGTTTTAATTGACCTATTCAGCGATTTCTGATTATTTCTTTTTCAATAGTTATGAAGAAAGGATGACTTACTTGACAGGAACCTCTGATCTTTCAAACA .....................................................................................................................(((.(((.........(((.......((.(((((((.((........))..)))))))))))).......(((....))).......))))))................................................................................................................................................................................ .....................................................................................................................118......................................................................................................223................................................................................................................................................................. | Size | Perfect hit | Total Norm | Perfect Norm | SRR314796(SRX084354) "Total RNA, fractionated (15-30nt)". (cell line) | SRR390723(GSM850202) total small RNA. (cell line) | SRR191607(GSM715717) 192genomic small RNA (size selected RNA from . (breast) | SRR342897(SRX096793) small RNA seq of Left atrial tissue. (heart) | SRR039190(GSM494809) PBMCs were isolated by ficoll gradient from t. (blood) | SRR387909(GSM843861) specific-host: Homo sapienshost cell line: Su. (cell line) | SRR189783 | SRR342898(SRX096794) small RNA seq of Right atrial tissue. (heart) | SRR342896(SRX096792) small RNA seq of Right atrial tissue. (heart) | SRR342899(SRX096795) small RNA seq of Left atrial tissue. (heart) | SRR342900(SRX096796) small RNA seq of Right atrial tissue. (heart) | SRR015448(SRR015448) cytoplasmic small RNAs. (breast) | SRR189784 | SRR342894(SRX096790) small RNA seq of Right atrial tissue. (heart) | SRR189785 | SRR189779(GSM714639) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330916(SRX091754) tissue: normal skindisease state: normal. (skin) | SRR039623(GSM531986) HCV(+) HCC Tissue Sample. (liver) | SRR330902(SRX091740) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR015446(SRR015446) smallRNAs high-throughput sequencing Total. (breast) | SRR029128(GSM416757) H520. (cell line) | RoviraIPAgo2(Rovira) total RNA. (ago2 breast) | SRR330905(SRX091743) tissue: normal skindisease state: normal. (skin) | SRR015359(GSM380324) Germinal Center B cell (GC136). (B cell) | SRR330914(SRX091752) tissue: normal skindisease state: normal. (skin) | SRR094130(GSM651906) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | GSM450601(GSM450601) miRNA sequencing raw reads from post-mortem s. (brain) | SRR330910(SRX091748) tissue: normal skindisease state: normal. (skin) | SRR330890(SRX091728) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330898(SRX091736) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR342901(SRX096797) small RNA seq of Left atrial tissue. (heart) | SRR033721(GSM497066) Ly3 cell line (Ly3). (B cell) | SRR189780(GSM714640) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330901(SRX091739) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330870(SRX091708) tissue: skin psoriatic involveddisease state:. (skin) | SRR330894(SRX091732) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330869(SRX091707) tissue: skin psoriatic involveddisease state:. (skin) | GSM450605(GSM450605) miRNA sequencing raw reads from post-mortem s. (brain) | SRR326280(GSM769510) total cell content of unperturbed cells was s. (cell line) | SRR330878(SRX091716) tissue: skin psoriatic involveddisease state:. (skin) | SRR029130(GSM416759) DLD2. (cell line) | SRR330887(SRX091725) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330861(SRX091699) tissue: skin psoriatic involveddisease state:. (skin) | SRR330893(SRX091731) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330895(SRX091733) tissue: skin psoriatic uninvolveddisease stat. (skin) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ..........................................................................................................................CAAGAATAGCAGGAATC....................................................................................................................................................................................................................................................... | 17 | 49.00 | 0.00 | 49.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..CAATGCTCTGAACTCTG............................................................................................................................................................................................................................................................................................................................................................................... | 17 | 34.00 | 0.00 | - | - | - | 9.00 | - | - | - | 4.00 | 2.00 | 2.00 | 2.00 | - | - | 2.00 | - | - | 2.00 | - | 1.00 | - | - | 1.00 | 1.00 | - | 1.00 | - | - | 1.00 | - | - | 1.00 | - | - | 1.00 | - | 1.00 | 1.00 | - | 1.00 | 1.00 | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCTATC. | 20 | 7.00 | 0.00 | 7.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .CCAATGCTCTGAACTCTG............................................................................................................................................................................................................................................................................................................................................................................... | 18 | 4.00 | 0.00 | - | - | - | - | - | - | - | - | 2.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | |
| .............ACTCTTCCCGCCTCCAGT................................................................................................................................................................................................................................................................................................................................................................... | 18 | 3.00 | 0.00 | - | - | - | - | - | - | 3.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .........................................................................................................................................................................................................AAGTGCGGAATAATTACA....................................................................................................................................................................... | 18 | 1 | 2.00 | 2.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 2.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCT.... | 17 | 1.00 | 0.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .........................................................................ACACTCATTTATCTTATTCA..................................................................................................................................................................................................................................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................................AAAGGCAGGCTTATATTTCCCCTAG........................................................................................................................................................................................................................................................................................................................... | 25 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...............................................................................................................................................................................................................................................................................................................................TATTTCTTTTTCAATAAAG................................................ | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .......................................................................................................................................................................................................................................................................................................................................................................TGACAGGAACCTCTG............ | 15 | 9 | 0.11 | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.11 |
| CCCAATGCTCTGAACTCTTCCCGCCTCCCGGAGCTCAGCCCTTGAGAAAGGCAGGCTTATATTTCCCTTAGTGACACTCATTTATCTTACAGCTCACCCCTTCTCATTTCTAAAGTATCCAGCAAGAATAGCAGGAAAAATTAGCTAAAGGCACCTAATGAATAAGCCTGCCTTTGCTCCAGAAATAATCGACAGATATCAAAGTGCGGAATAATTACAAGTAAACTTTCTCAACCAGTTTTTAACTACAACAATACATGTTGTGAATGAATATATTTGATAAAAATGGTTTTAATTGACCTATTCAGCGATTTCTGATTATTTCTTTTTCAATAGTTATGAAGAAAGGATGACTTACTTGACAGGAACCTCTGATCTTTCAAACA .....................................................................................................................(((.(((.........(((.......((.(((((((.((........))..)))))))))))).......(((....))).......))))))................................................................................................................................................................................ .....................................................................................................................118......................................................................................................223................................................................................................................................................................. | Size | Perfect hit | Total Norm | Perfect Norm | SRR314796(SRX084354) "Total RNA, fractionated (15-30nt)". (cell line) | SRR390723(GSM850202) total small RNA. (cell line) | SRR191607(GSM715717) 192genomic small RNA (size selected RNA from . (breast) | SRR342897(SRX096793) small RNA seq of Left atrial tissue. (heart) | SRR039190(GSM494809) PBMCs were isolated by ficoll gradient from t. (blood) | SRR387909(GSM843861) specific-host: Homo sapienshost cell line: Su. (cell line) | SRR189783 | SRR342898(SRX096794) small RNA seq of Right atrial tissue. (heart) | SRR342896(SRX096792) small RNA seq of Right atrial tissue. (heart) | SRR342899(SRX096795) small RNA seq of Left atrial tissue. (heart) | SRR342900(SRX096796) small RNA seq of Right atrial tissue. (heart) | SRR015448(SRR015448) cytoplasmic small RNAs. (breast) | SRR189784 | SRR342894(SRX096790) small RNA seq of Right atrial tissue. (heart) | SRR189785 | SRR189779(GSM714639) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330916(SRX091754) tissue: normal skindisease state: normal. (skin) | SRR039623(GSM531986) HCV(+) HCC Tissue Sample. (liver) | SRR330902(SRX091740) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR015446(SRR015446) smallRNAs high-throughput sequencing Total. (breast) | SRR029128(GSM416757) H520. (cell line) | RoviraIPAgo2(Rovira) total RNA. (ago2 breast) | SRR330905(SRX091743) tissue: normal skindisease state: normal. (skin) | SRR015359(GSM380324) Germinal Center B cell (GC136). (B cell) | SRR330914(SRX091752) tissue: normal skindisease state: normal. (skin) | SRR094130(GSM651906) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | GSM450601(GSM450601) miRNA sequencing raw reads from post-mortem s. (brain) | SRR330910(SRX091748) tissue: normal skindisease state: normal. (skin) | SRR330890(SRX091728) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330898(SRX091736) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR342901(SRX096797) small RNA seq of Left atrial tissue. (heart) | SRR033721(GSM497066) Ly3 cell line (Ly3). (B cell) | SRR189780(GSM714640) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330901(SRX091739) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330870(SRX091708) tissue: skin psoriatic involveddisease state:. (skin) | SRR330894(SRX091732) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330869(SRX091707) tissue: skin psoriatic involveddisease state:. (skin) | GSM450605(GSM450605) miRNA sequencing raw reads from post-mortem s. (brain) | SRR326280(GSM769510) total cell content of unperturbed cells was s. (cell line) | SRR330878(SRX091716) tissue: skin psoriatic involveddisease state:. (skin) | SRR029130(GSM416759) DLD2. (cell line) | SRR330887(SRX091725) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330861(SRX091699) tissue: skin psoriatic involveddisease state:. (skin) | SRR330893(SRX091731) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330895(SRX091733) tissue: skin psoriatic uninvolveddisease stat. (skin) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTTAGA.. | 19 | 9.67 | 0.00 | - | - | 3.67 | - | 1.78 | 1.78 | - | - | - | - | - | 0.67 | - | - | - | - | - | - | - | 0.78 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTTA.... | 17 | 9.11 | 0.00 | - | 7.67 | 0.89 | - | - | - | - | - | - | - | - | 0.56 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCT.... | 17 | 4.67 | 0.00 | - | 2.33 | 1.67 | - | - | - | - | - | - | - | - | 0.67 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCTAGA. | 20 | 4.67 | 0.00 | - | - | 1.33 | - | - | 2.67 | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - | - | |
| ..............................................................................................................................................................................................................................................TTTTTAACTACAACAAGC.................................................................................................................................. | 18 | 3.00 | 0.00 | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCTA... | 18 | 2.67 | 0.00 | - | 2.00 | 0.33 | - | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCTAG.. | 19 | 2.33 | 0.00 | - | - | 0.33 | - | 1.67 | - | - | - | - | - | - | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................ATCCAGCAAGAATAGGACT........................................................................................................................................................................................................................................................... | 19 | 2.00 | 0.00 | - | - | 2.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTTAG... | 18 | 1.56 | 0.00 | - | - | 0.33 | - | 0.78 | - | - | - | - | - | - | 0.22 | - | - | - | - | - | - | - | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.11 | - | - | - | - | |
| ....................................................................................................................................................................................................................................GTAGTTAAAAACTGGTTGAGA......................................................................................................................................... | 21 | 1 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ..........................................................................................................................................................................................................................................................................ATGAATATATTTGATAATTG.................................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .......................................................................................TACAGCTCACCCCTTTAT......................................................................................................................................................................................................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | |
| ............................................................................................CTCACCCCTTCTCATATA.................................................................................................................................................................................................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ......GCTCTGAACTCTTCCCGAA......................................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................................................TAAGCCTGCCTTTGCTCCAGAAATAATCG................................................................................................................................................................................................... | 29 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................................................................................................................................................................................................................................ATTGTTGTAGTTAAAAA................................................................................................................................... | 17 | 2 | 1.00 | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ........................................................................................................................................................................................................AAAGTGCGGAATAATTATTG...................................................................................................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................................................................................................................................................................................................................................TTTTTAACTACAACAGC................................................................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...............................................................................................................................................................................................................................................ATTGTTGTAGTTAAAA................................................................................................................................... | 16 | 3 | 0.67 | 0.67 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | 0.33 | - |
| .............................................................................................................................................................................................................................................................................................................................................................................GAAAGATCAGAGGTTC..... | 16 | 3 | 0.33 | 0.33 | - | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTCTAC.. | 19 | 0.33 | 0.00 | - | - | - | - | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................GAGCTGTAAGATAAATGA................................................................................................................................................................................................................................................................................................... | 18 | 3 | 0.33 | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - |
| .....................................................................................................................................................................TGGAGCAAAGGCAGGC............................................................................................................................................................................................................. | 16 | 6 | 0.17 | 0.17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTTAT... | 18 | 0.11 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTTC.... | 17 | 0.11 | 0.00 | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................GAACCTCTGATCTTTTCG... | 18 | 0.11 | 0.00 | - | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................AAAGATCAGAGGTTC...... | 15 | 9 | 0.11 | 0.11 | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |