ID: uc002jpl.2_intron_0_0_chr17_73774805_r
GENE: (3)
chr17:73774755-73774940-


(3)
AGO2.ip 		(8)
B-CELL 		(2)
BRAIN 		(11)
BREAST 		(28)
CELL-LINE 		(9)
CERVIX 		(2)
HEART 		(6)
HELA 		(1)
KIDNEY 		(6)
LIVER 		(3)
OTHER 		(37)
SKIN 		(1)
TESTES 		(3)
UTERUS 		(1)
XRN.ip

Sense strand
ATTTCAAAACCGACCTGAGGTTTCAGAGCGCAGCCATCGGTGCGCTGCAGGTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGGGATTAATAGTGCGGCTCTCGTCCTCAACAGGAGGCTAGCGAAGCGTACCTGGTGGGTCTGTTCGAAGATACCAACCTGTG
............................................................(((.....)))(((.((((((((.((...((((((((...))))))))......)).)))))))).))).........................................................
..................................................51..............................................................................131.....................................................
SizePerfect hitTotal NormPerfect NormRoviraIPAgo2(Rovira)
total RNA. (ago2 breast)		DRR001488(DRX001042)
"Hela short nuclear cell fraction, LNA(+)". (hela)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		DRR001486(DRX001040)
"Hela long cytoplasmic cell fraction, LNA(+)". (hela)		DRR001489(DRX001043)
"Hela short nuclear cell fraction, control". (hela)		SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		DRR001485(DRX001039)
"Hela long total cell fraction, LNA(+)". (hela)		SRR037938(GSM510476)
293Red. (cell line)		SRR553576(SRX182782)
source: Testis. (testes)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)		SRR037940(GSM510478)
293cand5_rep2. (cell line)		SRR330874(SRX091712)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)		GSM532876(GSM532876)
G547T. (cervix)		SRR330863(SRX091701)
tissue: skin psoriatic involveddisease state:. (skin)		SRR037939(GSM510477)
293cand5_rep1. (cell line)		DRR001487(DRX001041)
"Hela long nuclear cell fraction, LNA(+)". (hela)		SRR330921(SRX091759)
tissue: normal skindisease state: normal. (skin)		SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)		TAX577738(Rovira)
total RNA. (breast)		SRR330916(SRX091754)
tissue: normal skindisease state: normal. (skin)		SRR330880(SRX091718)
tissue: skin psoriatic involveddisease state:. (skin)		DRR000555(DRX000313)
"THP-1 whole cell RNA, no treatment". (cell line)		SRR330890(SRX091728)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR094131(GSM651907)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		GSM532874(GSM532874)
G699T. (cervix)		SRR330904(SRX091742)
tissue: normal skindisease state: normal. (skin)		SRR040008(GSM532893)
G727N. (cervix)		SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)		SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR040025(GSM532910)
G613T. (cervix)		SRR330896(SRX091734)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR444052(SRX128900)
Sample 12cDNABarcode: AF-PP-340: ACG CTC TTC . (skin)		SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR330861(SRX091699)
tissue: skin psoriatic involveddisease state:. (skin)		TAX577742(Rovira)
total RNA. (breast)		SRR330902(SRX091740)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039622(GSM531985)
HCV(+) Adjacent Tissue Sample. (liver)		GSM956925Ago2PAZ(GSM956925)
"cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line)		SRR039619(GSM531982)
HBV(+) HCC Tissue Sample 1. (liver)		SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)		SRR094129(GSM651905)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR330879(SRX091717)
tissue: skin psoriatic involveddisease state:. (skin)		SRR553575(SRX182781)
source: Kidney. (Kidney)		GSM359192(GSM359192)
HepG2_3pM_6. (cell line)		GSM359208(GSM359208)
hepg2_bindASP_hl_2. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR330867(SRX091705)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330872(SRX091710)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039621(GSM531984)
HBV(+) HCC Tissue Sample 2. (liver)		SRR330905(SRX091743)
tissue: normal skindisease state: normal. (skin)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR039191(GSM494810)
PBMCs were isolated by ficoll gradient from t. (blood)		SRR330900(SRX091738)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR330857(SRX091695)
tissue: skin psoriatic involveddisease state:. (skin)		SRR033722(GSM497067)
KMS12 cell line (KMS12). (B cell)		SRR330914(SRX091752)
tissue: normal skindisease state: normal. (skin)		SRR191568(GSM715678)
51genomic small RNA (size selected RNA from t. (breast)		SRR330913(SRX091751)
tissue: normal skindisease state: normal. (skin)		SRR342894(SRX096790)
small RNA seq of Right atrial tissue. (heart)		SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)		DRR000557(DRX000315)
"THP-1 whole cell RNA, after 3 day treatment . (cell line)		SRR060985(GSM569189)
Human naive B cell [09-001]. (cell line)		SRR191557(GSM715667)
57genomic small RNA (size selected RNA from t. (breast)		SRR039618(GSM531981)
HBV(+) Side Tissue Sample 1. (liver)		SRR330910(SRX091748)
tissue: normal skindisease state: normal. (skin)		SRR330864(SRX091702)
tissue: skin psoriatic involveddisease state:. (skin)		SRR040036(GSM532921)
G243N. (cervix)		SRR343333(GSM796036)
KSHV (HHV8). (cell line)		SRR033726(GSM497071)
Mututated CLL (CLLM633). (B cell)		SRR330884(SRX091722)
tissue: skin psoriatic uninvolveddisease stat. (skin)		TAX577741(Rovira)
total RNA. (breast)		SRR015447(SRR015447)
nuclear small RNAs. (breast)		SRR038854(GSM458537)
MM653. (cell line)		SRR037932(GSM510470)
293cand4_rep1. (cell line)		SRR033732(GSM497077)
bjab cell line (bjab103). (B cell)		SRR330871(SRX091709)
tissue: skin psoriatic involveddisease state:. (skin)		SRR040014(GSM532899)
G623N. (cervix)		SRR330899(SRX091737)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		SRR390723(GSM850202)
total small RNA. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		SRR330868(SRX091706)
tissue: skin psoriatic involveddisease state:. (skin)		DRR001483(DRX001037)
"Hela long cytoplasmic cell fraction, control. (hela)		TAX577579(Rovira)
total RNA. (breast)		SRR029130(GSM416759)
DLD2. (cell line)		SRR330894(SRX091732)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR444053(SRX128901)
Sample 13cDNABarcode: AF-PP-341: ACG CTC TTC . (skin)		SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		SRR326282(GSM769512)
"Dicer mRNA was knocked down using siDicer, t. (cell line)		SRR033714(GSM497059)
Burkitt Lymphoma (BL134). (B cell)		SRR207116(GSM721078)
Nuclear RNA. (cell line)		TAX577453(Rovira)
total RNA. (breast)		SRR330866(SRX091704)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330878(SRX091716)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330920(SRX091758)
tissue: normal skindisease state: normal. (skin)		SRR330895(SRX091733)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR033729(GSM497074)
splenic MZL (Splenic414). (B cell)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR189784SRR040037(GSM532922)
G243T. (cervix)		GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR444046(SRX128894)
Sample 7cDNABarcode: AF-PP-342: ACG CTC TTC C. (skin)		SRR040016(GSM532901)
G645N. (cervix)		SRR040039(GSM532924)
G531T. (cervix)		SRR330917(SRX091755)
tissue: normal skindisease state: normal. (skin)		GSM450610(GSM450610)
miRNA sequencing raw reads from post-mortem s. (brain)		DRR000559(DRX000317)
"THP-1 whole cell RNA, no treatment". (cell line)		GSM956925Ago2(GSM956925)
"cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line)		SRR191414(GSM715524)
31genomic small RNA (size selected RNA from t. (breast)		SRR060168(GSM565978)
5-8F_nucleus. (cell line)		SRR191591(GSM715701)
53genomic small RNA (size selected RNA from t. (breast)		SRR330859(SRX091697)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330908(SRX091746)
tissue: normal skindisease state: normal. (skin)		SRR444060(SRX128908)
Sample 18cDNABarcode: AF-PP-340: ACG CTC TTC . (skin)
.................................CCATCGGTGCGCTGCAG........................................................................................................................................17122.0022.00-9.00--6.002.00-------------2.00-----1.00-----------------1.00----------------------------------------1.00---------------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGGGATTAATAGTGCGGCTCTCGTCCTCAACAG..................................................8619.009.00---2.00---6.00-----------1.00--------------------------------------------------------------------------------------------------
..................................CATCGGTGCGCTGCAG........................................................................................................................................1618.008.00-4.00--3.00------------1.00----------------------------------------------------------------------------------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGGGATTAATAGTGCGGCTCTCGTCCTCAACAGA.................................................8716.009.00---6.00------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................TACCTGGTGGGTCTGTTCGA...............2016.006.00------1.00-------1.00---------------------------2.00-----1.00------------------------------------------1.00--------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCGAAGATACCAACC....2716.006.00--------6.00-------------------------------------------------------------------------------------------------------------
...............................................................................................TCCCCGAGTGGGATTAATAGTGCGGAA................................................................2716.001.00------------4.00-----2.00---------------------------------------------------------------------------------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGGGATTAATAGTGCGGCTCTCGTCCTCAAC....................................................8415.005.00---4.00----------------------------------------------------------------------------------1.00-------------------------------
..............................................................................................................................................................TGGGTCTGTTCGAAGATA..........1814.004.00------4.00---------------------------------------------------------------------------------------------------------------
..................................................................................................................................................................TCTGTTCGAAGATACC........1614.004.00----------------------------------2.00--------------1.00------1.00-------------------------------------------------------------
...............................................................................................................................................................GGGTCTGTTCGAAGATACCAAC.....2214.004.00----------------2.00-----------2.00-----------------------------------------------------------------------------------------
..........................................................................................................................................................CTGGTGGGTCTGTTCGAAG.............1913.003.00----------2.00---------1.00-------------------------------------------------------------------------------------------------
...................................................................................................................................................................CTGTTCGAAGATACCAAC.....1813.003.00-----------------------------------2.00------------------------------------------------------1.00---------------------------
......................................................................................................................................AGGAGGCTAGCGAAGCGTA.................................1923.003.00------1.50-------------------------------------0.50------------------1.00------------------------------------------------------
..................................................................................................................................................................TCTGTTCGAAGATACCAAC.....1913.003.00--------------------------------------2.00------------------------------1.00------------------------------------------------
...................................ATCGGTGCGCTGCAGGAGG....................................................................................................................................1913.001.00----------1.00-----------1.00---------------------------------------------------1.00-------------------------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGGGATTAATAGTGCGG..................................................................7013.003.00-------3.00--------------------------------------------------------------------------------------------------------------
............................................................................................................................................................GGTGGGTCTGTTCGAAGAT...........1913.003.00---------------------2.00----------------------1.00-------------------------------------------------------------------------
...................................................................................................................................................................CTGTTCGAAGATACC........1522.502.50---------------------------------------1.00------0.50--------------------------------------------------1.00--------------------
.................................................GGTAAGACAAAGGCCTGGAGCCGGGGGAGGGCT........................................................................................................3312.002.002.00---------------------------------------------------------------------------------------------------------------------
...................................ATCGGTGCGCTGCAGGT......................................................................................................................................1712.002.00----1.001.00----------------------------------------------------------------------------------------------------------------
.........................................................................................................................................................CCTGGTGGGTCTGTTCGAA..............1912.002.00---------------2.00------------------------------------------------------------------------------------------------------
..............................................................................................................................................................TGGGTCTGTTCGAAGATACA........2012.001.00------1.00-----------------------------------------------------------------------1.00---------------------------------------
..................................................GTAAGACAAAGGCCTGGAAGA...................................................................................................................212.000.00-----------2.00----------------------------------------------------------------------------------------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCGAAGATAC.........2212.002.00--------------------------------------------------------------1.00------------------------------------1.00------------------
..................................................................................................................................................................TCTGTTCGAAGATACCAACC....2012.002.00------------------------2.00---------------------------------------------------------------------------------------------
..TTCAAAACCGACCTGGTC......................................................................................................................................................................182.000.00---------------------------------2.00------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGCCTG....................242.000.00--2.00-------------------------------------------------------------------------------------------------------------------
.....AAAACCGACCTGAGGTTTCAGAGCGCAGCC.......................................................................................................................................................3012.002.00--2.00-------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................TACCTGGTGGGTCTGTTCGAAGATA..........2512.002.00---------2.00------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCGAAGATA..........2112.002.00--------------------------------2.00-------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGTCTGCTCG................282.000.00------------------------------------2.00---------------------------------------------------------------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCGAAGA............1912.002.00---------------------------1.00------------------------1.00-----------------------------------------------------------------
.......................CAGAGCGCAGCCATCGGTGC...............................................................................................................................................2012.002.00--1.00---------------------------1.00---------------------------------------------------------------------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGGGAGGGC.........................................................................................................3112.002.00-----2.00----------------------------------------------------------------------------------------------------------------
..TTCAAAACCGACCTGAGGTTTCAGAGC.............................................................................................................................................................2712.002.00---------2.00------------------------------------------------------------------------------------------------------------
..................................CATCGGTGCGCTGCAGGAGG....................................................................................................................................202.000.001.00----1.00----------------------------------------------------------------------------------------------------------------
.................................CCATCGGTGCGCTGCAGGAGG....................................................................................................................................212.000.00--------------------------------------------------------------------1.00--------------1.00----------------------------------
...................................................................................................................................................................CTGTTCGAAGATACCAACCT...2012.002.00---------------------------1.00-------------------------------1.00----------------------------------------------------------
..........................................................................................................................................................CTGGTGGGTCTGTTCGAAGATAC.........2312.002.00---------------------------------------------1.00----1.00-------------------------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTGGTGGGT.......................2321.501.501.50---------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTCTGTCCG................2421.500.50--1.50-------------------------------------------------------------------------------------------------------------------
.......................CAGAGCGCAGCCATCGGTG................................................................................................................................................1911.001.00----------------------------------------------------------------------------------1.00-----------------------------------
............................................................................................................................................................GGTGGGTCTGTTCGAAG.............1711.001.00------------------------------------------------------------1.00---------------------------------------------------------
.................................................................................................................................................................GTCTGTTCGAAGATACCA.......1811.001.00------1.00---------------------------------------------------------------------------------------------------------------
..............................................................................................................................................................TGGGTCTGTTCGAAG.............1511.001.00-------------1.00--------------------------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGTCTGTTCG................2811.001.00--1.00-------------------------------------------------------------------------------------------------------------------
..........................................................................................................................CTCGTCCTCAACAGGA................................................1611.001.00----1.00-----------------------------------------------------------------------------------------------------------------
......AAACCGACCTGAGGTTTCAG................................................................................................................................................................2011.001.00----------------------------------------1.00-----------------------------------------------------------------------------
......................................................................................................GTGGGATTAATAGTGCGGCTCTCGT...........................................................2511.001.00-----------------------------------------------------------------1.00----------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTGGTGGG........................2221.001.001.00---------------------------------------------------------------------------------------------------------------------
......................................................................................................GTGGGATTAATAGTGCGGCTCTCGTC..........................................................2611.001.00------------------------------------------------------1.00---------------------------------------------------------------
..................................CATCGGTGCGCTGCAGGTAAGACAAAGG............................................................................................................................2811.001.00--------------------------1.00-------------------------------------------------------------------------------------------
..................................................GTAAGACAAAGGCCTGGAG.....................................................................................................................1911.001.00--------------------------------------------------------------------------------------------1.00-------------------------
...................GTTTCAGAGCGCAGCCATCGG..................................................................................................................................................2111.001.00--------------------------1.00-------------------------------------------------------------------------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCGAAG.............1811.001.00------1.00---------------------------------------------------------------------------------------------------------------
...........................................................................................CCGCTCCCCGAGTGGGATTAATAGTGCGGCTCTCGT...........................................................3611.001.00-----------------------------------------------1.00----------------------------------------------------------------------
...................................ATCGGTGCGCTGCAGGAGGC...................................................................................................................................2011.001.00-------------------------------1.00--------------------------------------------------------------------------------------
..........................................................................................................................................................CTGGTGGGTCTGTTCGAAGATA..........2211.001.00--------------------1.00-------------------------------------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTCTGTTCG................2411.001.00--1.00-------------------------------------------------------------------------------------------------------------------
...............................................................CTGGAGCCGGGGGAGGGC.........................................................................................................1811.001.00-------------------------------------------------------------1.00--------------------------------------------------------
...............................................................................................TCCCCGAGTGGGATTAATAGTGCGG..................................................................2511.001.00-------------------------------------------------------------------------------1.00--------------------------------------
.....................................................................................................................CGGCTCTCGTCCTCAACAGGAGGCTA...........................................2611.001.00-----------------------------1.00----------------------------------------------------------------------------------------
..............................................................................................................................................................TGGGTCTGTTCGAAGATACC........2011.001.00-----------------------------1.00----------------------------------------------------------------------------------------
................................GCCATCGGTGCGCTGCAG........................................................................................................................................1811.001.00-1.00--------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTCTGTT..................2221.001.00---------------------0.50-------------------------0.50----------------------------------------------------------------------
...................GTTTCAGAGCGCAGCCATCGGTG................................................................................................................................................2311.001.00----1.00-----------------------------------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGTCTGTTCGAAG.............3111.001.00--1.00-------------------------------------------------------------------------------------------------------------------
.........CCGACCTGAGGTTTCAGAGC.............................................................................................................................................................2011.001.00-----------------------1.00----------------------------------------------------------------------------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGT................................................................................561.000.00---1.00------------------------------------------------------------------------------------------------------------------
......................................................................CGGGGGAGGGCTGGGCGGTT................................................................................................2011.001.00----------------------------------------------------------1.00-----------------------------------------------------------
.................AGGTTTCAGAGCGCAGCCACCGG..................................................................................................................................................231.000.00--1.00-------------------------------------------------------------------------------------------------------------------
...........................................................................................................ATTAATAGTGCGGCTCTCGTCCTCAACAG..................................................2911.001.00--------------------------------------------------------------------------------------------------1.00-------------------
....................................................................................................................................................GCGTACCTGGTGGGTCTGTTCGAAG.............2511.001.00-----------------------1.00----------------------------------------------------------------------------------------------
...................................ATCGGTGCGCTGCAGGTAAGACA................................................................................................................................2311.001.00-------------------------------------------------------1.00--------------------------------------------------------------
.................................................................................................................................................GAAGCGTACCTGGTGGGTCT.....................2021.001.00-----------------------------------------------------------------------------------------------------------0.50----0.50-----
......................TCAGAGCGCAGCCATCGGT.................................................................................................................................................1911.001.00---------------------------------------------------------------------------------------1.00------------------------------
.................................................................................................................................................................GTCTGTTCGAAGATACC........1711.001.00------------------------------------------------------------------------------------------------1.00---------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGGG...............................................................................................................2511.001.00-------------------------------------1.00--------------------------------------------------------------------------------
........................................................................................................GGGATTAATAGTGCGG..................................................................1611.001.00----------------------------------------------------------------1.00-----------------------------------------------------
..............................CAGCCATCGGTGCGCTGCAGGAG.....................................................................................................................................231.000.00---------------------------------------1.00------------------------------------------------------------------------------
.......................................................................GGGGGAGGGCTGGGCGGTTT...............................................................................................2011.001.00---------------------------------------------------------1.00------------------------------------------------------------
.......................................................................GGGGGAGGGCTGGGCGGTTTA..............................................................................................2111.001.00----------------------------------------------------------------------1.00-----------------------------------------------
...................................ATCGGTGCGCTGCAGG.......................................................................................................................................1611.001.00-----1.00----------------------------------------------------------------------------------------------------------------
....................................................................................................GAGTGGGATTAATAGTGCGGC.................................................................2111.001.00------------------------------1.00---------------------------------------------------------------------------------------
..........CGACCTGAGGTTTCAGAGCGCAGCCATCGGT.................................................................................................................................................3111.001.00----------------------1.00-----------------------------------------------------------------------------------------------
......................................................................................................................................................GTACCTGGTGGGTCTGTTCGAAGATA..........2611.001.00-----1.00----------------------------------------------------------------------------------------------------------------
.................................................................................................CCCGAGTGGGATTAATAGTGCGGCTCTC.............................................................2811.001.00-----------------------------------------------------------------------------1.00----------------------------------------
.........................................................................................................................................AGGCTAGCGAAGCGTACCTGGTGGGTC......................2721.001.001.00---------------------------------------------------------------------------------------------------------------------
...............TGAGGTTTCAGAGCGCAGCCATCGGTG................................................................................................................................................2711.001.00-----------------------------------------1.00----------------------------------------------------------------------------
...........................................GCTGCAGGTAAGACAAAGGC...........................................................................................................................2011.001.00-------------------------------------------------------------------------------------1.00--------------------------------
..........................................................................................................GATTAATAGTGCGGCTCTCG............................................................2011.001.001.00---------------------------------------------------------------------------------------------------------------------
........................................................................................................................................................ACCTGGTGGGTCTGTTCGACGTC...........231.000.00-------------------------------------------------------------------1.00--------------------------------------------------
................................................................................................CCCCGAGTGGGATTAATAGTGCGGCTCTC.............................................................2911.001.00------------------1.00---------------------------------------------------------------------------------------------------
..........................................................................................................................................................CTGGTGGGTCTGTTCGA...............1711.001.00-----1.00----------------------------------------------------------------------------------------------------------------
...................................................................................................................................................AGCGTACCTGGTGGGTCTGTTCG................2311.001.00---------------1.00------------------------------------------------------------------------------------------------------
................................................................................................................................................CGAAGCGTACCTGGTGGG........................1821.001.000.50---------------------------------------------------------------------------------------------------------0.50-----------
.........................................................................................................................................AGGCTAGCGAAGCGTACCTGGTGGGTCTGTTC.................3211.001.00---------1.00------------------------------------------------------------------------------------------------------------
..................................CATCGGTGCGCTGCAGGAGGC...................................................................................................................................211.000.001.00---------------------------------------------------------------------------------------------------------------------
.......................................................................GGGGGAGGGCTGGGCGCG.................................................................................................181.000.00-----------------------------------------1.00----------------------------------------------------------------------------
.............................................................................................................................................................GTGGGTCTGTTCGAAGATA..........1911.001.00-------------------------------1.00--------------------------------------------------------------------------------------
..................................CATCGGTGCGCTGCAGGTAAGACA................................................................................................................................2411.001.00-----------------------------------------------------1.00----------------------------------------------------------------
....................................................................................................................................................GCGTACCTGGTGGGTCTGTTCGAAGA............2611.001.00----------------------------------------------------------------------------------------------1.00-----------------------
.....................................................................CCGGGGGAGGGCTGGGCGGTTTA..............................................................................................231.000.00------------------------------------------------------------------------1.00---------------------------------------------
................................................................................................................................CTCAACAGGAGGCTAGCGAAG.....................................2111.001.00-----------------1.00----------------------------------------------------------------------------------------------------
.....................................................................................................................................................CGTACCTGGTGGGTCTGTTCGAAGATAC.........2811.001.001.00---------------------------------------------------------------------------------------------------------------------
..........................................................................................................................................................CTGGTGGGTCTGTTCGAA..............1811.001.00----------------------------------------------------------------------------------------------------1.00-----------------
........................................................................................................GGGATTAATAGTGCGGCTCTCGAAA.........................................................251.000.00-----------------------------------------------------------------------------------------------------1.00----------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGTCTGTCCG................281.000.00--1.00-------------------------------------------------------------------------------------------------------------------
.........CCGACCTGAGGTTTCAGAGCGCAGCCA......................................................................................................................................................2711.001.00-----------1.00----------------------------------------------------------------------------------------------------------
............................................................................................................................................................GGTGGGTCTGTTCGAAGATTT.........2111.003.00---------------------------------------------------------------------------------------------1.00------------------------
..................................................GTAAGACAAAGGCCTGGAGCCGGG................................................................................................................2411.001.00-------------------------------------1.00--------------------------------------------------------------------------------
..........................................................AAGGCCTGGAGCCGGGGGAGGG..........................................................................................................2211.001.00--------------------------------------------------------------------------------1.00-------------------------------------
.......................................................................................................................................................TACCTGGTGGGTCTGTTCGATT.............2211.006.00----------------------------------------------1.00-----------------------------------------------------------------------
....................................................................................................................GCGGCTCTCGTCCTCAACAG..................................................2011.001.00-----------------------------------------------------------------------1.00----------------------------------------------
...............................AGCCATCGGTGCGCTGC..........................................................................................................................................1711.001.00----------------1.00-----------------------------------------------------------------------------------------------------
.............................................................................................................................................TAGCGAAGCGTACCTGGTGGGTCTGCTCG................291.000.00--1.00-------------------------------------------------------------------------------------------------------------------
.....................................................................................................................................................CGTACCTGGTGGGTCTGTTCGAAGATA..........2711.001.00-----1.00----------------------------------------------------------------------------------------------------------------
.....................................................................................................AGTGGGATTAATAGTGCGG..................................................................1911.001.00--------------1.00-------------------------------------------------------------------------------------------------------
.......................................................................................................TGGGATTAATAGTGCGGCTCTCGTC..........................................................2511.001.00----------------------------------------------------------------------------1.00-----------------------------------------
............ACCTGAGGTTTCAGAGCGC...........................................................................................................................................................1921.001.00--------------------0.50------------------------0.50------------------------------------------------------------------------
................................................................................................................................................CGAAGCGTACCTGGTGGGTCTGTTCGAA..............2811.001.00----------------------------------------------------------------------------------------1.00-----------------------------
......................................................................................................................................................................TTCGAAGATACCAACCTG..1811.001.00-------------1.00--------------------------------------------------------------------------------------------------------
...................................................................................................................................................................CTGTTCGAAGATACCAACC....1911.001.00---------------------------------------------------------------------------------1.00------------------------------------
.................................................................................................................................................GAAGCGTACCTGGTGGGTCTGTTGGG...............261.000.00---------------------------------------------------------------------------1.00------------------------------------------
..............................................................................................................................................................TGGGTCTGTTCGAAGATAC.........1911.001.00----------1.00-----------------------------------------------------------------------------------------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCGAAGAT...........2011.001.00-----1.00----------------------------------------------------------------------------------------------------------------
................GAGGTTTCAGAGCGCAGCCATCGGTGCGCTGCAGG.......................................................................................................................................3511.001.001.00---------------------------------------------------------------------------------------------------------------------
................................................................................................................................................CGAAGCGTACCTGGTGGGTCTGTTCGAAGA............3011.001.00----------------------------------------1.00-----------------------------------------------------------------------------
......................................................................................................................................AGGAGGCTAGCGAAGCGTACCTGGTGGGTCTGTGA.................351.000.001.00---------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTG..........................1821.001.000.50-----0.50---------------------------------------------------------------------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTGG............................1821.001.00-----------------------------------------------------------------------------------------0.50---------------0.50------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGTCTGTCCGC...............291.000.00--1.00-------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................AGCGTACCTGGTGGGTCTGTTCGAAGA............2711.001.00-----------1.00----------------------------------------------------------------------------------------------------------
..............................................................................................................AATAGTGCGGCTCTCGTCC.........................................................1911.001.00-------------------------------------------------------------------------1.00--------------------------------------------
........................................................................................................GGGATTAATAGTGCGGCTCTCGTCCTCACCAG..................................................321.000.00-----------------------------------------------------------------------------------------------1.00----------------------
........................................................................................................................................................ACCTGGTGGGTCTGTTCGAA..............2011.001.00------------------------------------------------------------------1.00---------------------------------------------------
...................................ATCGGTGCGCTGCAGGTAAGACAAAGGCC..........................................................................................................................2911.001.00-----------------1.00----------------------------------------------------------------------------------------------------
.................................................................................................................................................................GTCTGTTCGAAGATACCAA......1911.001.00------1.00---------------------------------------------------------------------------------------------------------------
.............................................TGCAGGTAAGACAAAGGC...........................................................................................................................1811.001.00--------------1.00-------------------------------------------------------------------------------------------------------
........................................................................................................................................GAGGCTAGCGAAGCGTACCTGGTGG.........................2520.500.50-------------0.50--------------------------------------------------------------------------------------------------------
................................................................................................................................................CGAAGCGTACCTGGTGG.........................1720.500.50-0.50--------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTCTGTCC.................2320.500.50--0.50-------------------------------------------------------------------------------------------------------------------
...........................................................................................................................................................TGGTGGGTCTGTTCG................1520.500.50-----0.50----------------------------------------------------------------------------------------------------------------
...................................................................................................................................................AGCGTACCTGGTGGGTCTGTTA.................2220.500.50------------------------------------------------------------------------------------------------------------------0.50---
...............................................................................................................................................GCGAAGCGTACCTGGTGGGTCTGTT..................2520.500.50-----0.50----------------------------------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGGGTC......................2220.500.500.50---------------------------------------------------------------------------------------------------------------------
..............................................................................................................................................AGCGAAGCGTACCTGGTGG.........................1920.500.500.50---------------------------------------------------------------------------------------------------------------------
.............................................TGCAGGTAAGACAAAG.............................................................................................................................1620.500.50---------------------------------------------------0.50------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTC......................1820.500.50---------------0.50------------------------------------------------------------------------------------------------------
..................GGTTTCAGAGCGCAGC........................................................................................................................................................1620.500.50--------------------------------------------------------------------------------------------------------------0.50-------
..........................................................................................................................................GGCTAGCGAAGCGTACCTGGTGGGTCTG....................2820.500.50-----------------------0.50----------------------------------------------------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTGGTG..........................2020.500.500.50---------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................AGCGTACCTGGTGGGTCTGTT..................2120.500.50----------0.50-----------------------------------------------------------------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTGGTGGGTC......................2420.500.500.50---------------------------------------------------------------------------------------------------------------------
...............................................................................................................................................GCGAAGCGTACCTGGTGG.........................1820.500.50-------------0.50--------------------------------------------------------------------------------------------------------
................GAGGTTTCAGAGCGCAGC........................................................................................................................................................1820.500.500.50---------------------------------------------------------------------------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTG.............................1720.500.50-------------------------------------------------------------------------------------------------------------------0.50--
.....................................................................................................................................CAGGAGGCTAGCGAAGCGTACCTGG............................2520.500.50-----------------------------------------------------------------------------------------0.50----------------------------
................................................................................................................................................CGAAGCGTACCTGGTGGGTC......................2020.500.50----------------------0.50-----------------------------------------------------------------------------------------------
.........................................................................................................................................AGGCTAGCGAAGCGTACCTGGTGGGTCTGTT..................3120.500.50-------------0.50--------------------------------------------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTCTGT...................2120.500.50-----------------------------------------------------------------------------------------------------------------0.50----
.....................................................................................................................................CAGGAGGCTAGCGAAGCGTAC................................2120.500.50---------------------------------------------------------------------------------------------------------------0.50------
...........GACCTGAGGTTTCAGAGC.............................................................................................................................................................1820.500.50-------------------------------------------------------------------------------------------------------0.50--------------
....................................TCGGTGCGCTGCAGG.......................................................................................................................................1520.500.50-------------------------0.50--------------------------------------------------------------------------------------------
......................................................................................................................................................GTACCTGGTGGGTCTGT...................1720.500.50---------------------------------------------------0.50------------------------------------------------------------------
............................................................................................................................................CTAGCGAAGCGTACCTGGTGG.........................2120.500.500.50---------------------------------------------------------------------------------------------------------------------
..................GGTTTCAGAGCGCAGCC.......................................................................................................................................................1720.500.50------------------------------------------------------------------------------------------------------------0.50---------
...............................................................................................................................................GCGAAGCGTACCTGGTGGGTCTG....................2320.500.50--------------0.50-------------------------------------------------------------------------------------------------------
..................................................................................................................................................AAGCGTACCTGGTGGGTCTG....................2020.500.50------------------------------------------------------------------------------------------------------0.50---------------
......................................................................................................................................AGGAGGCTAGCGAAGCG...................................1720.500.50--------------------------------------------------------------------------------------------------------0.50-------------
.................................................................................................................................................GAAGCGTACCTGGTGGGTC......................1920.500.50-------------------------------------------0.50--------------------------------------------------------------------------
..............CTGAGGTTTCAGAGCGCA..........................................................................................................................................................1820.500.50-------------------------0.50--------------------------------------------------------------------------------------------
.....................................................................................................................................CAGGAGGCTAGCGAAGCGTACCT..............................2320.500.50-------------------------------------------------------------------------------------------------------------0.50--------
..................................................................................................................................................................TCTGTTCGAAGATAC.........1530.330.33--------------------------------------------------------------------------------------------------------------------0.33-
....................................................AAGACAAAGGCCTGGAGC....................................................................................................................1860.170.17----0.17-----------------------------------------------------------------------------------------------------------------

Antisense strand
ATTTCAAAACCGACCTGAGGTTTCAGAGCGCAGCCATCGGTGCGCTGCAGGTAAGACAAAGGCCTGGAGCCGGGGGAGGGCTGGGCGGTTTCCGCTCCCCGAGTGGGATTAATAGTGCGGCTCTCGTCCTCAACAGGAGGCTAGCGAAGCGTACCTGGTGGGTCTGTTCGAAGATACCAACCTGTG
............................................................(((.....)))(((.((((((((.((...((((((((...))))))))......)).)))))))).))).........................................................
..................................................51..............................................................................131.....................................................
SizePerfect hitTotal NormPerfect NormRoviraIPAgo2(Rovira)
total RNA. (ago2 breast)		DRR001488(DRX001042)
"Hela short nuclear cell fraction, LNA(+)". (hela)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		DRR001486(DRX001040)
"Hela long cytoplasmic cell fraction, LNA(+)". (hela)		DRR001489(DRX001043)
"Hela short nuclear cell fraction, control". (hela)		SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		DRR001485(DRX001039)
"Hela long total cell fraction, LNA(+)". (hela)		SRR037938(GSM510476)
293Red. (cell line)		SRR553576(SRX182782)
source: Testis. (testes)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)		SRR037940(GSM510478)
293cand5_rep2. (cell line)		SRR330874(SRX091712)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)		GSM532876(GSM532876)
G547T. (cervix)		SRR330863(SRX091701)
tissue: skin psoriatic involveddisease state:. (skin)		SRR037939(GSM510477)
293cand5_rep1. (cell line)		DRR001487(DRX001041)
"Hela long nuclear cell fraction, LNA(+)". (hela)		SRR330921(SRX091759)
tissue: normal skindisease state: normal. (skin)		SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)		TAX577738(Rovira)
total RNA. (breast)		SRR330916(SRX091754)
tissue: normal skindisease state: normal. (skin)		SRR330880(SRX091718)
tissue: skin psoriatic involveddisease state:. (skin)		DRR000555(DRX000313)
"THP-1 whole cell RNA, no treatment". (cell line)		SRR330890(SRX091728)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR094131(GSM651907)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		GSM532874(GSM532874)
G699T. (cervix)		SRR330904(SRX091742)
tissue: normal skindisease state: normal. (skin)		SRR040008(GSM532893)
G727N. (cervix)		SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)		SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR040025(GSM532910)
G613T. (cervix)		SRR330896(SRX091734)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR444052(SRX128900)
Sample 12cDNABarcode: AF-PP-340: ACG CTC TTC . (skin)		SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR330861(SRX091699)
tissue: skin psoriatic involveddisease state:. (skin)		TAX577742(Rovira)
total RNA. (breast)		SRR330902(SRX091740)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039622(GSM531985)
HCV(+) Adjacent Tissue Sample. (liver)		GSM956925Ago2PAZ(GSM956925)
"cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line)		SRR039619(GSM531982)
HBV(+) HCC Tissue Sample 1. (liver)		SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)		SRR094129(GSM651905)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)		SRR330879(SRX091717)
tissue: skin psoriatic involveddisease state:. (skin)		SRR553575(SRX182781)
source: Kidney. (Kidney)		GSM359192(GSM359192)
HepG2_3pM_6. (cell line)		GSM359208(GSM359208)
hepg2_bindASP_hl_2. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR330867(SRX091705)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330872(SRX091710)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039621(GSM531984)
HBV(+) HCC Tissue Sample 2. (liver)		SRR330905(SRX091743)
tissue: normal skindisease state: normal. (skin)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR039191(GSM494810)
PBMCs were isolated by ficoll gradient from t. (blood)		SRR330900(SRX091738)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR330857(SRX091695)
tissue: skin psoriatic involveddisease state:. (skin)		SRR033722(GSM497067)
KMS12 cell line (KMS12). (B cell)		SRR330914(SRX091752)
tissue: normal skindisease state: normal. (skin)		SRR191568(GSM715678)
51genomic small RNA (size selected RNA from t. (breast)		SRR330913(SRX091751)
tissue: normal skindisease state: normal. (skin)		SRR342894(SRX096790)
small RNA seq of Right atrial tissue. (heart)		SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)		DRR000557(DRX000315)
"THP-1 whole cell RNA, after 3 day treatment . (cell line)		SRR060985(GSM569189)
Human naive B cell [09-001]. (cell line)		SRR191557(GSM715667)
57genomic small RNA (size selected RNA from t. (breast)		SRR039618(GSM531981)
HBV(+) Side Tissue Sample 1. (liver)		SRR330910(SRX091748)
tissue: normal skindisease state: normal. (skin)		SRR330864(SRX091702)
tissue: skin psoriatic involveddisease state:. (skin)		SRR040036(GSM532921)
G243N. (cervix)		SRR343333(GSM796036)
KSHV (HHV8). (cell line)		SRR033726(GSM497071)
Mututated CLL (CLLM633). (B cell)		SRR330884(SRX091722)
tissue: skin psoriatic uninvolveddisease stat. (skin)		TAX577741(Rovira)
total RNA. (breast)		SRR015447(SRR015447)
nuclear small RNAs. (breast)		SRR038854(GSM458537)
MM653. (cell line)		SRR037932(GSM510470)
293cand4_rep1. (cell line)		SRR033732(GSM497077)
bjab cell line (bjab103). (B cell)		SRR330871(SRX091709)
tissue: skin psoriatic involveddisease state:. (skin)		SRR040014(GSM532899)
G623N. (cervix)		SRR330899(SRX091737)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		SRR390723(GSM850202)
total small RNA. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		SRR330868(SRX091706)
tissue: skin psoriatic involveddisease state:. (skin)		DRR001483(DRX001037)
"Hela long cytoplasmic cell fraction, control. (hela)		TAX577579(Rovira)
total RNA. (breast)		SRR029130(GSM416759)
DLD2. (cell line)		SRR330894(SRX091732)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR444053(SRX128901)
Sample 13cDNABarcode: AF-PP-341: ACG CTC TTC . (skin)		SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		SRR326282(GSM769512)
"Dicer mRNA was knocked down using siDicer, t. (cell line)		SRR033714(GSM497059)
Burkitt Lymphoma (BL134). (B cell)		SRR207116(GSM721078)
Nuclear RNA. (cell line)		TAX577453(Rovira)
total RNA. (breast)		SRR330866(SRX091704)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330878(SRX091716)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330920(SRX091758)
tissue: normal skindisease state: normal. (skin)		SRR330895(SRX091733)
tissue: skin psoriatic uninvolveddisease stat. (skin)		SRR033729(GSM497074)
splenic MZL (Splenic414). (B cell)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR189784SRR040037(GSM532922)
G243T. (cervix)		GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR444046(SRX128894)
Sample 7cDNABarcode: AF-PP-342: ACG CTC TTC C. (skin)		SRR040016(GSM532901)
G645N. (cervix)		SRR040039(GSM532924)
G531T. (cervix)		SRR330917(SRX091755)
tissue: normal skindisease state: normal. (skin)		GSM450610(GSM450610)
miRNA sequencing raw reads from post-mortem s. (brain)		DRR000559(DRX000317)
"THP-1 whole cell RNA, no treatment". (cell line)		GSM956925Ago2(GSM956925)
"cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line)		SRR191414(GSM715524)
31genomic small RNA (size selected RNA from t. (breast)		SRR060168(GSM565978)
5-8F_nucleus. (cell line)		SRR191591(GSM715701)
53genomic small RNA (size selected RNA from t. (breast)		SRR330859(SRX091697)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330908(SRX091746)
tissue: normal skindisease state: normal. (skin)		SRR444060(SRX128908)
Sample 18cDNABarcode: AF-PP-340: ACG CTC TTC . (skin)
.......................GATGGCTGCGCTCTG.................................................................................................................................................... 1530.330.33-------------------------------------------0.33--------------------------------------------------------------------------
....................................................................................................CTATTAATCCCACTC....................................................................... 1550.200.20---------------------------------------------------------------------------------------------------------------------0.20