ID: uc001vzw.2_intron_7_0_chr14_21731496_r.3p
GENE: (1)
chr14:21731446-21731695-


(2)
AGO2.ip 		(1)
AGO3.ip 		(8)
B-CELL 		(2)
BRAIN 		(3)
BREAST 		(23)
CELL-LINE 		(2)
CERVIX 		(2)
HEART 		(5)
HELA 		(1)
KIDNEY 		(8)
LIVER 		(2)
OTHER 		(14)
SKIN 		(2)
XRN.ip

Sense strand
CCTCTCTACTTCCTCGTGTATTTTTAAGATTGATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAAACTTTATCCTTGCGGTTTTTGTGGAAACTGCTTTTGGAAAGAGAAAAGAAATGAACTTTACTGACTTGACATTTTTGCACCTCCCGTTTTTCTAATCTGGGCTATTTTTATTTTTGTTTTTTTACAGTGAGATTTTTTTGATCTTCAGCTACAGTAAGTTATTCCAATTTTTTTTTA
............................................................................................................((((((((...(((((((................)))))))....))).....)))))....................................................................................
............................................................................................................109......................................................................182..................................................................
SizePerfect hitTotal NormPerfect NormSRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		SRR387909(GSM843861)
specific-host: Homo sapienshost cell line: Su. (cell line)		SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)		GSM359208(GSM359208)
hepg2_bindASP_hl_2. (cell line)		SRR189784DRR001486(DRX001040)
"Hela long cytoplasmic cell fraction, LNA(+)". (hela)		SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR039622(GSM531985)
HCV(+) Adjacent Tissue Sample. (liver)		SRR207110(GSM721072)
Nuclear RNA. (cell line)		SRR189786SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		RoviraIPAgo2(Rovira)
total RNA. (ago2 breast)		GSM450607(GSM450607)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR342894(SRX096790)
small RNA seq of Right atrial tissue. (heart)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		DRR001489(DRX001043)
"Hela short nuclear cell fraction, control". (hela)		SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)		SRR189782DRR001482(DRX001036)
"Hela long total cell fraction, control". (hela)		SRR039616(GSM531979)
HBV(+) Distal Tissue Sample 1. (liver)		SRR037935(GSM510473)
293cand3. (cell line)		SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)		SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)		SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		SRR207116(GSM721078)
Nuclear RNA. (cell line)		SRR039624(GSM531987)
HBV(-) HCV(-) Adjacent Tissue Sample. (liver)		SRR033711(GSM497056)
GCB DLBCL (GCB110). (B cell)		SRR330874(SRX091712)
tissue: skin psoriatic involveddisease state:. (skin)		SRR189777(GSM714637)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR330889(SRX091727)
tissue: skin psoriatic uninvolveddisease stat. (skin)		DRR001488(DRX001042)
"Hela short nuclear cell fraction, LNA(+)". (hela)		SRR330865(SRX091703)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330905(SRX091743)
tissue: normal skindisease state: normal. (skin)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR037936(GSM510474)
293cand1. (cell line)		SRR330879(SRX091717)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)		SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)		SRR039625(GSM531988)
HBV(-) HCV(-) HCC Tissue Sample. (liver)		SRR330913(SRX091751)
tissue: normal skindisease state: normal. (skin)		SRR553575(SRX182781)
source: Kidney. (Kidney)		SRR189787SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)		SRR553573(SRX182779)
source: Cerebellum. (Cerebellum)		SRR330864(SRX091702)
tissue: skin psoriatic involveddisease state:. (skin)		SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)		SRR189785SRR060982(GSM569186)
Human centrocyte [09-001]. (cell line)		SRR033726(GSM497071)
Mututated CLL (CLLM633). (B cell)		SRR039612(GSM531975)
Human Normal Liver Tissue Sample 2. (liver)		TAX577741(Rovira)
total RNA. (breast)		SRR040025(GSM532910)
G613T. (cervix)		SRR330871(SRX091709)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330861(SRX091699)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		GSM956925AGO2Paz8(GSM956925)
"cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line)		GSM1105750AGO3(GSM1105750)
small RNA sequencing data. (ago3 hela)		SRR060168(GSM565978)
5-8F_nucleus. (cell line)		GSM450602(GSM450602)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR330869(SRX091707)
tissue: skin psoriatic involveddisease state:. (skin)		SRR189776(GSM714636)
cell line: HEK293clip variant: CLIPenzymatic . (cell line)		SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR330916(SRX091754)
tissue: normal skindisease state: normal. (skin)		SRR330886(SRX091724)
tissue: skin psoriatic uninvolveddisease stat. (skin)		TAX577745(Rovira)
total RNA. (breast)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR207119(GSM721081)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		DRR000559(DRX000317)
"THP-1 whole cell RNA, no treatment". (cell line)		SRR330859(SRX091697)
tissue: skin psoriatic involveddisease state:. (skin)		SRR040031(GSM532916)
G013T. (cervix)
...............................................................................................................................................................TTTTTCTAATCTGGGCTAT........................................................................19114.0014.00--13.00----1.00-------------------------------------------------------------------
..........................AGATTGATTGATGATGTGGAA...........................................................................................................................................................................................................21112.0012.00----12.00----------------------------------------------------------------------
...............................GATTGATGATGTGGAAAGGGCTTTGCTTGTCTG..........................................................................................................................................................................................3316.006.00------6.00--------------------------------------------------------------------
..............................................................................................................................................................................CTATTTTTATTTTTGTTTTTTTACAGCGAG..............................................305.000.003.00-2.00------------------------------------------------------------------------
...............................GATTGATGATGTGGAAAGGG.......................................................................................................................................................................................................2015.005.00---3.00------------------------2.00----------------------------------------------
................................ATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAAACTTTATCCTTGCGGTTTTTGTGGAAA......................................................................................................................................................6815.005.00--------5.00------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTCTT.......................................................285.000.00-5.00-------------------------------------------------------------------------
................................................................................................................................................................................ATTTTTATTTTTGTTTTTTTACAGCGAG..............................................284.000.003.001.00-------------------------------------------------------------------------
..............................................AAGGGCTTTGCTTGTGAG..........................................................................................................................................................................................184.000.00------------4.00--------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTCT......................................................2813.001.001.002.00-------------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTCTT......................................................293.000.001.002.00-------------------------------------------------------------------------
.........................................................................................................................................................................CTGGGCTATTTTTATTTTTGTTTTTTC......................................................273.000.00-3.00-------------------------------------------------------------------------
........................................TGTGGAAAGGGCTTTGCTT...............................................................................................................................................................................................1913.003.00----------1.00-------2.00--------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTAC.....................................................273.000.001.002.00-------------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTCT......................................................293.000.002.001.00-------------------------------------------------------------------------
...............................GATTGATGATGTGGAAAGGGCTTT...................................................................................................................................................................................................2413.003.00---1.00--------------------------1.00---------------------1.00----------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTC......................................................293.000.002.001.00-------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTC......................................................2813.002.001.002.00-------------------------------------------------------------------------
..............................................................................................................................................................................CTATTTTTATTTTTGTTTTTTTACAGTGAG..............................................3012.002.00--2.00------------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTCAC....................................................312.000.002.00--------------------------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTTTC......................................................302.000.002.00--------------------------------------------------------------------------
...................................GATGATGTGGAAAGGGCTT....................................................................................................................................................................................................1912.002.00-----1.00----1.00----------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTTCAC...................................................322.000.002.00--------------------------------------------------------------------------
.......................................ATGTGGAAAGGGCTTTGCTTGTCCGC.........................................................................................................................................................................................262.000.00-2.00-------------------------------------------------------------------------
..................................TGATGATGTGGAAAGGGCTT....................................................................................................................................................................................................2012.002.00---------2.00-----------------------------------------------------------------
.....................................TGATGTGGAAAGGGCTTTG..................................................................................................................................................................................................1912.002.00----------2.00----------------------------------------------------------------
.........................................GTGGAAAGGGCTTTGCTTGTCT...........................................................................................................................................................................................2212.002.00----------------2.00----------------------------------------------------------
............................ATTGATTGATGATGTGGAAAG.........................................................................................................................................................................................................2112.002.00-----2.00---------------------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTT........................................................2812.002.001.001.00-------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTTCAC...................................................292.000.002.00--------------------------------------------------------------------------
...............................................................................................................................................................................TATTTTTATTTTTGTTTTTTTACAGCGAG..............................................292.000.002.00--------------------------------------------------------------------------
..............................................................................................................................................................................CTATTTTTATTTTTGTTTTTTTACAGCGA...............................................292.000.00--2.00------------------------------------------------------------------------
.................................................................................................................................................................TTTCTAATCTGGGCTAT........................................................................1712.002.00--1.00----1.00-------------------------------------------------------------------
.........................................................................................................................................................................CTGGGCTATTTTTATTTTTGTTTTTTTACAA..................................................312.000.00--2.00------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTTACA...................................................3112.002.001.001.00-------------------------------------------------------------------------
.......................................................................................................................................................................................TTTTTGTTTTTTTACAGTGAGATTTTTTTGA....................................3112.002.002.00--------------------------------------------------------------------------
...................................GATGATGTGGAAAGGGCTTTG..................................................................................................................................................................................................2112.002.00---------2.00-----------------------------------------------------------------
.........................AAGATTGATTGATGATGTGGAAAGGGCT.....................................................................................................................................................................................................2812.002.00-1.00---------1.00---------------------------------------------------------------
.................................................................................................................................................................TTTCTAATCTGGGCTATTTT.....................................................................2012.002.00-------2.00-------------------------------------------------------------------
.................................................................................................................GAGAAAAGAAATGAACTT.......................................................................................................................1812.002.00------------------------2.00--------------------------------------------------
..........................................................................................................TTGGAAAGAGAAAAGAAATGAACT........................................................................................................................2412.002.00---2.00-----------------------------------------------------------------------
...................................................................................................................GAAAAGAAATGAACTTTACTGACTTGACATTTTTGCACCTCCCGTTTTTCTAATCTGGG............................................................................5912.002.00--------2.00------------------------------------------------------------------
................................................................................................................................................................TTTTCTAATCTGGGCTAT........................................................................1812.002.00-1.001.00------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTA......................................................2812.002.00-1.00-----------------------------------------------1.00-------------------------
................................ATTGATGATGTGGAAAGG........................................................................................................................................................................................................1812.002.00---2.00-----------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTC.......................................................282.000.002.00--------------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTTACAG..................................................3312.002.002.00--------------------------------------------------------------------------
..............................TGATTGATGATGTGGAAAGGGCTTTGC.................................................................................................................................................................................................2712.002.00---------------2.00-----------------------------------------------------------
............................................................................................................................................................................GGCTATTTTTATTTTTGTTTTTTTACAGCG................................................302.000.001.00-1.00------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTT.......................................................2712.002.00-2.00-------------------------------------------------------------------------
......................................................................................................GCTTTTGGAAAGAGAAAAGAAATGA...........................................................................................................................2512.002.00-----------------------------2.00---------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTCTTT......................................................292.000.002.00--------------------------------------------------------------------------
.................................................................................................................................................................................TTTTTATTTTTGTTTTTTTACAGTGA...............................................2612.002.00-------------2.00-------------------------------------------------------------
........................................................................................................................GAAATGAACTTTACTGACTT..............................................................................................................2012.002.00--------------------2.00------------------------------------------------------
......................TTTAAGATTGATTGATGATGTGGAAAGGGCTTT...................................................................................................................................................................................................3312.002.00--------------1.00----------------------------------------1.00-------------------
...................................GATGATGTGGAAAGGGCTTT...................................................................................................................................................................................................2012.002.00---------1.00-----------------------------------------------------1.00-----------
.........................AAGATTGATTGATGATGTGGAAAGGG.......................................................................................................................................................................................................2612.002.00---2.00-----------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTCTTT......................................................262.000.00-2.00-------------------------------------------------------------------------
......................................................................................................................................................................................ATTTTTGTTTTTTTACAGTGAGATTTTTG.......................................292.000.002.00--------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTCTC......................................................282.000.002.00--------------------------------------------------------------------------
..................TATTTTTAAGATTGATTGATGACG................................................................................................................................................................................................................242.000.00-------------2.00-------------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTCGTT...........................................................252.000.002.00--------------------------------------------------------------------------
................................................................................................................................................................TTTTCTAATCTGGGCTATTTTTATTTTTG.............................................................2911.001.00-------1.00-------------------------------------------------------------------
................................ATTGATGATGTGGAAAGGGCTTTG..................................................................................................................................................................................................2411.001.00-----------------------------------1.00---------------------------------------
...................................................................................TGCGGTTTTTGTGGAAACT....................................................................................................................................................1911.001.00--------------1.00------------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTTCAC.....................................................3111.002.001.00--------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTTACAGC.................................................3311.001.00-1.00-------------------------------------------------------------------------
........................................TGTGGAAAGGGCTTTGCTTGTCT...........................................................................................................................................................................................2311.001.00-----------------------------------------1.00---------------------------------
...............................................................................................................................................................TTTTTCTAATCTGGGCTATTTTTG...................................................................241.000.00--------------------------------1.00------------------------------------------
..............................TGATTGATGATGTGGAAAGGGC......................................................................................................................................................................................................2211.001.00---1.00-----------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTCTTT......................................................281.000.001.00--------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTACAG...................................................291.000.001.00--------------------------------------------------------------------------
.........................................................................................................................................................................CTGGGCTATTTTTATTTTTGTTTCTTT......................................................271.000.001.00--------------------------------------------------------------------------
......................................................................................................................................................................................ATTTTTGTTTTTTTACAGTGAGATTTTTCT......................................301.000.001.00--------------------------------------------------------------------------
..............................TGATTGATGATGTGGAAAGGGCTTTGCTTGTC............................................................................................................................................................................................3211.001.00----------------------------------------------------------------1.00----------
...............................................................................................................................................................................TATTTTTATTTTTGTTTTTTTACAGCG................................................271.000.00-1.00-------------------------------------------------------------------------
..........................AGATTGATTGATGATGTGGAAAGGGCTTTGC.................................................................................................................................................................................................3111.001.00------------------------------------------------1.00--------------------------
............................ATTGATTGATGATGTGGAAAGGTC......................................................................................................................................................................................................241.000.00--------------------------------------------------1.00------------------------
...............................GATTGATGATGTGGAAAGGGCTTTGA.................................................................................................................................................................................................2611.001.00---1.00-----------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTACA....................................................311.000.001.00--------------------------------------------------------------------------
.............................................................................................................................................................................GCTATTTTTATTTTTGTTTTTTACAG...................................................261.000.001.00--------------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTCTTA......................................................291.000.001.00--------------------------------------------------------------------------
....................TTTTTAAGATTGATTGA.....................................................................................................................................................................................................................1711.001.00----------------------------------------1.00----------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTCT.......................................................271.000.001.00--------------------------------------------------------------------------
...................................GATGATGTGGAAAGGGCTTTGCTTGTC............................................................................................................................................................................................2711.001.00-----------1.00---------------------------------------------------------------
..............................TGATTGATGATGTGGAAAGGGCTTT...................................................................................................................................................................................................2511.001.00-----------------------------------------------1.00---------------------------
................................................................................................................................................................................................................TTTTGATCTTCAGCTACAGTAAG...................2311.001.00-------------------------------1.00-------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTCTTA.....................................................271.000.001.00--------------------------------------------------------------------------
...............................................................................................................................................................TTTTTCTAATCTGGGCTATTTTTATTTTTG.............................................................3011.001.00--1.00------------------------------------------------------------------------
........................................TGTGGAAAGGGCTTTGCTTG..............................................................................................................................................................................................2011.001.00-----------------------------------------------------------1.00---------------
...............................GATTGATGATGTGGAAAG.........................................................................................................................................................................................................1811.001.00-----1.00---------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTCTTT.......................................................281.000.001.00--------------------------------------------------------------------------
...............................................................................................................AAGAGAAAAGAAATGAACTTTACTGAC................................................................................................................2711.001.00-----------------1.00---------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTCTC.......................................................281.000.00-1.00-------------------------------------------------------------------------
................................ATTGATGATGTGGAAAGGGCTTT...................................................................................................................................................................................................2311.001.00----------------------------------------------------------------------1.00----
...............................GATTGATGATGTGGAAAGGGCTT....................................................................................................................................................................................................2311.001.00-------------------------1.00-------------------------------------------------
..............................................................................................................................................................................................................TTTTTTGATCTTCAGCTGTAT.......................211.000.00----------------------------------------------1.00----------------------------
...............................................................................TCCTTGCGGTTTTTGTGGAAACTGC..................................................................................................................................................2511.001.00-------------------1.00-------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTTA.....................................................2711.001.001.00--------------------------------------------------------------------------
...............................................................................................................................................................TTTTTCTAATCTGGGCTAC........................................................................191.000.00--1.00------------------------------------------------------------------------
...............................................................................................................................................................TTTTTCTAATCTGGGCCAT........................................................................191.000.00--1.00------------------------------------------------------------------------
............................ATTGATTGATGATGTGGAAAGGA.......................................................................................................................................................................................................231.000.00-------------------------------------------------------------1.00-------------
...............................................................................................................................................................................................TTTTTACAGTGAGATTTTTTTGATCT.................................2611.001.001.00--------------------------------------------------------------------------
..........................................................................................................................................................................................................AGATTTTTTTGATCTCAGC.............................191.000.001.00--------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTCT........................................................261.000.00-1.00-------------------------------------------------------------------------
....................................ATGATGTGGAAAGGGCTTTGCTTGTC............................................................................................................................................................................................2611.001.00-------------------------1.00-------------------------------------------------
.........................AAGATTGATTGATGATGTGGAAAGGGCTTTGCT................................................................................................................................................................................................3311.001.00--------------1.00------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTTACAGAA................................................3411.001.00-----------------------------------------------------------------------1.00---
..............................................AAGGGCTTTGCTTGTCTGCTACT.....................................................................................................................................................................................2311.001.00-------------------------------------1.00-------------------------------------
...............................GATTGATGATGTGGAAAGGGC......................................................................................................................................................................................................2111.001.00-----------------------------------------------------1.00---------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTACAG....................................................311.000.001.00--------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTCCAC.....................................................271.000.001.00--------------------------------------------------------------------------
..............................................................................................................................................................................CTATTTTTATTTTTGTTTTTTTACAGTG................................................2811.001.00--1.00------------------------------------------------------------------------
....................................................................................................................................................................................TTATTTTTGTTTTTTTACAGCGAG..............................................241.000.001.00--------------------------------------------------------------------------
...............................................AGGGCTTTGCTTGTCTGCTACTG....................................................................................................................................................................................2311.001.00--------------------------------------------------------------1.00------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTCGT............................................................231.000.00-1.00-------------------------------------------------------------------------
..............................................................................................................................AACTTTACTGACTTGACATT........................................................................................................2011.001.00------------------------------------------1.00--------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTCTAC....................................................3011.001.001.00--------------------------------------------------------------------------
................................ATTGATGATGTGGAAAGGGCT.....................................................................................................................................................................................................2111.001.00-----------1.00---------------------------------------------------------------
....................................................................................................................................................................................................................................AAGTTATTCCAATTTTTTTAAC221.000.001.00--------------------------------------------------------------------------
........................................TGTGGAAAGGGCTTTGCTTGT.............................................................................................................................................................................................2111.001.00-----------------------1.00---------------------------------------------------
....................................ATGATGTGGAAAGGGCTTCGC.................................................................................................................................................................................................211.000.00--1.00------------------------------------------------------------------------
.............................TTGATTGATGATGTGGAAAGGGCTTCGC.................................................................................................................................................................................................281.000.00-1.00-------------------------------------------------------------------------
.................................................................................................................................TTTACTGACTTGACATTTTTG....................................................................................................2111.001.00---------------------1.00-----------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTCTAC....................................................281.000.001.00--------------------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTTACAG..................................................3211.001.001.00--------------------------------------------------------------------------
.............................................................................................................GAAAGAGAAAAGAAATGAACTTTACT...................................................................................................................2611.001.00-----1.00---------------------------------------------------------------------
....................................................TTTGCTTGTCTGCTACTGCAA.................................................................................................................................................................................211.000.00-------------------1.00-------------------------------------------------------
...............................................................................................................................ACTTTACTGACTTGAGATC........................................................................................................191.000.00-------------------------------------------1.00-------------------------------
.........................................................................................................................................................................CTGGGCTATTTTTATTTTTGTTTTTTTACAGTG................................................3311.001.00--1.00------------------------------------------------------------------------
.............................TTGATTGATGATGTGGA............................................................................................................................................................................................................1711.001.00---------------------------------------------1.00-----------------------------
..........................................................................................................................................TTGACATTTTTGCACCTCCCG...........................................................................................2111.001.00---------------------------------------------------1.00-----------------------
................................ATTGATGATGTGGAAAGGGCTTTGCTTGTCTG..........................................................................................................................................................................................3211.001.00------1.00--------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTC.........................................................261.000.00-1.00-------------------------------------------------------------------------
............................ATTGATTGATGATGTGG.............................................................................................................................................................................................................1711.001.00---------------------------------------------------------1.00-----------------
........................................................................................................................................................................................................TGAGATTTTTTTGATCTTCAGCACAG........................261.000.001.00--------------------------------------------------------------------------
..........................................................................................................................................................................................................AGATTTTTTTGATCTTCAGCTACTC.......................251.000.00-1.00-------------------------------------------------------------------------
................................ATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCT........................................................................................................................................................................................3411.001.00-------------------1.00-------------------------------------------------------
................................ATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAAACTTTATCCTTGCGGTTTTTGTGG.........................................................................................................................................................6511.001.00----------------------1.00----------------------------------------------------
..........................AGATTGATTGATGATGTGGAAAGGGCT.....................................................................................................................................................................................................2711.001.00-----------1.00---------------------------------------------------------------
........................................................................AACTTTATCCTTGCGGTTTTTGTGGAA.......................................................................................................................................................2711.001.00--------------------------------------------1.00------------------------------
.....................................TGATGTGGAAAGGGCTTT...................................................................................................................................................................................................1811.001.00--------------------1.00------------------------------------------------------
..............................................AAGGGCTTTGCTTGTTTAA.........................................................................................................................................................................................191.000.00--------------------------------------------------------1.00------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTTTT......................................................2811.001.001.00--------------------------------------------------------------------------
................................................................................................................................................TTTTTGCACCTCCCGTTTTTCTA...................................................................................2311.001.00-----------------1.00---------------------------------------------------------
....................................................................................................................................ACTGACTTGACATTTTTGCATA................................................................................................221.000.00-----1.00---------------------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTC........................................................281.000.001.00--------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTCAA....................................................281.000.00-1.00-------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTCAC....................................................281.000.001.00--------------------------------------------------------------------------
..........................................................................................................................................................................................................AGATTTTTTTGATCTTCAGCTACAGCAAG...................291.000.00-1.00-------------------------------------------------------------------------
..........................................................................................................................................................................................TTGTTTTTTTACAGTGAGATTTTTTC......................................261.000.001.00--------------------------------------------------------------------------
...............................GATTGATGATGTGGAAAGGGCT.....................................................................................................................................................................................................2211.001.00---------1.00-----------------------------------------------------------------
.........................................................................ACTTTATCCTTGCGGTTTTTGTGG.........................................................................................................................................................2411.001.00-------------------------------------------------------------------1.00-------
...............................................AGGGCTTTGCTTGTCTGC.........................................................................................................................................................................................1811.001.00-------------1.00-------------------------------------------------------------
..............................................................................................................................................................................CTATTTTTATTTTTGTTTTTTTACAGCG................................................281.000.00--1.00------------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTCTT........................................................271.000.001.00--------------------------------------------------------------------------
....................................ATGATGTGGAAAGGGCTTTGC.................................................................................................................................................................................................2111.001.00--1.00------------------------------------------------------------------------
..................................................................................TTGCGGTTTTTGTGGAAA......................................................................................................................................................1811.001.00-----------------------1.00---------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATC.................................................................181.000.001.00--------------------------------------------------------------------------
.............................................AAAGGGCTTTGCTTGTCTGCTACTG....................................................................................................................................................................................2511.001.00-------1.00-------------------------------------------------------------------
.................................................................................................................................................................................................................TTTGATCTTCAGCTACAG.......................1811.001.00------------1.00--------------------------------------------------------------
...............................................................................................................................................................TTTTTCTAATCTGGGCTATTTTTATTGTC..............................................................291.000.00--1.00------------------------------------------------------------------------
.............................TTGATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAA.................................................................................................................................................................................4411.001.00--------1.00------------------------------------------------------------------
.......................TTAAGATTGATTGATGATGTGGAAAGGGC......................................................................................................................................................................................................2911.001.00-1.00-------------------------------------------------------------------------
......................................................TGCTTGTCTGCTACTGAAAACT..............................................................................................................................................................................2211.001.00---------------------------1.00-----------------------------------------------
.........................................................................................................TTTGGAAAGAGAAAAGAAATGA...........................................................................................................................2211.001.00-----------1.00---------------------------------------------------------------
.........................................................................................................................................................................CTGGGCTATTTTTATTTGTTT............................................................211.000.001.00--------------------------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTTC.......................................................2911.002.00-1.00-------------------------------------------------------------------------
.......................................ATGTGGAAAGGGCTTTGCT................................................................................................................................................................................................1911.001.00------------------1.00--------------------------------------------------------
...............................................................................................................................................................TTTTTCTAATCTGGGCTATTTTCAT..................................................................251.000.00-1.00-------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTC......................................................261.000.00-1.00-------------------------------------------------------------------------
........................................TGTGGAAAGGGCTTTGCT................................................................................................................................................................................................1811.001.00--------------------------------------1.00------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTTAC......................................................3011.002.00-1.00-------------------------------------------------------------------------
..................TATTTTTAAGATTGATTGATGATGTGGAAAGGG.......................................................................................................................................................................................................3311.001.00--------------1.00------------------------------------------------------------
...............................................................................................................................................................................TATTTTTATTTTTGTTTTTTTTTCC..................................................251.000.001.00--------------------------------------------------------------------------
.......................................................................................................................AGAAATGAACTTTACTGACTTGA............................................................................................................2311.001.00-----1.00---------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTCTTA.....................................................301.000.001.00--------------------------------------------------------------------------
...........................................................................................................................ATGAACTTTACTGACTTGACATTTTTGCACCTCCCGTTTTTCTAATCTGGGCTATTTTTATTTTTGTTTTTTTACAG..................................................7711.001.00----------------------1.00----------------------------------------------------
......................................GATGTGGAAAGGGCTTTGCTTG..............................................................................................................................................................................................2211.001.00----------1.00----------------------------------------------------------------
........................................................................................................................................................................TCTGGGCTATTTTTATTTTTGTTTTT........................................................2611.001.00-1.00-------------------------------------------------------------------------
..............................TGATTGATGATGTGGAAAGGGCTTTG..................................................................................................................................................................................................2611.001.00--------------------------1.00------------------------------------------------
...........................................................................................TTGTGGAAACTGCTTTTTGC...........................................................................................................................................201.000.00----------------------------------1.00----------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTTACTT..................................................331.000.00-1.00-------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTTACA...................................................2911.001.00-1.00-------------------------------------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTCTT......................................................261.000.001.00--------------------------------------------------------------------------
.......................................................................................GTTTTTGTGGAAACTGCT.................................................................................................................................................1811.001.00---------1.00-----------------------------------------------------------------
........................................TGTGGAAAGGGCTTTGCTA...............................................................................................................................................................................................1911.001.00------------------------------1.00--------------------------------------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTACA....................................................281.000.001.00--------------------------------------------------------------------------
.........................................................................................................................................................................CTGGGCTATTTTTATTTTTGTTTTTTTACAG..................................................3111.001.00-1.00-------------------------------------------------------------------------
......................TTTAAGATTGATTGATGATGTGGAAAG.........................................................................................................................................................................................................2711.001.00------------------------------------------------------1.00--------------------
..............................................................................................................................AACTTTACTGACTTGACATTTTT.....................................................................................................2311.001.00-------1.00-------------------------------------------------------------------
...........................GATTGATTGATGATGTGGAAAGGG.......................................................................................................................................................................................................2411.001.00---1.00-----------------------------------------------------------------------
...................................................................................................................................................................TCTAATCTGGGCTATTTTTATTTTTG.............................................................2611.001.00--------------------------1.00------------------------------------------------
...........................................................................................TTGTGGAAACTGCTTTTGGAAAG........................................................................................................................................2311.001.00----------------1.00----------------------------------------------------------
................................................................CTACTGAAAACTTTATCCTTGCGGT.................................................................................................................................................................2511.001.00---------------------------1.00-----------------------------------------------
................TGTATTTTTAAGATTGATTGAT....................................................................................................................................................................................................................2211.001.00------------------------------------------------------------1.00--------------
..........................................................................................................................................................................TGGGCTATTTTTATTTTTGTTTTTTTACAG..................................................3011.001.001.00--------------------------------------------------------------------------
..................................................................................TTGCGGTTTTTGTGGAAAC.....................................................................................................................................................1911.001.00---------------------------------1.00-----------------------------------------
...........................................GGAAAGGGCTTTGCTTGTCT...........................................................................................................................................................................................2011.001.00---------------------------------------1.00-----------------------------------
...............................GATTGATGATGTGGAAAGGGCTTTG..................................................................................................................................................................................................2511.001.00---1.00-----------------------------------------------------------------------
............................ATTGATTGATGATGTGGAAAGGGCTC....................................................................................................................................................................................................261.000.001.00--------------------------------------------------------------------------
.............................TTGATTGATGATGTGGAAAGGGCTTT...................................................................................................................................................................................................2611.001.00--------------------------------------------------------------------1.00------
......................................................................................................................................................................................ATTTTTGTTTTTTTACAGTG................................................2011.001.001.00--------------------------------------------------------------------------
.........................................................................ACTTTATCCTTGCGGTTTTTGT...........................................................................................................................................................2211.001.00-----1.00---------------------------------------------------------------------
......................................GATGTGGAAAGGGCTTTGCTTT..............................................................................................................................................................................................221.000.00----------1.00----------------------------------------------------------------
......................................GATGTGGAAAGGGCTTTGCTTGTCT...........................................................................................................................................................................................2511.001.00-----------1.00---------------------------------------------------------------
................................................................................................................................................................................................................TTTTGATCTTCAGCTACAGTAA....................2211.001.00----------------------------------------------------------1.00----------------
............................................................................................................................................................................................................ATTTTTTTGATCTTCAGCTACAGTAAGCT.................291.000.00--1.00------------------------------------------------------------------------
...............................GATTGATGATGTGGAAAGGGCTTTGC.................................................................................................................................................................................................2611.001.00---------------------------------------------------------------------1.00-----
.....................................................................................................................................................................................................CAGTGAGATTTTTTTGAT...................................1811.001.00-----------------1.00---------------------------------------------------------
..................................................................................................................................TTACTGACTTGACATTTTT.....................................................................................................1911.001.00------------------------------------1.00--------------------------------------
....................................ATGATGTGGAAAGGGCTTTGCTTG..............................................................................................................................................................................................2411.001.00-----1.00---------------------------------------------------------------------
...............................................AGGGCTTTGCTTGTCTGCTACCGA...................................................................................................................................................................................241.000.001.00--------------------------------------------------------------------------
...................ATTTTTAAGATTGATTGATGATGTGGA............................................................................................................................................................................................................2711.001.00---------------1.00-----------------------------------------------------------
......................................................................................................................................................................AATCTGGGCTATTTTTATTTTTGTTTTTTTTA....................................................321.000.00-1.00-------------------------------------------------------------------------
.................................................................................................................................................................................TTTTTATTTTTGTTTTTTTACTTTC................................................251.000.001.00--------------------------------------------------------------------------
...................................................................................................................................................................TCTAATCTGGGCTATTTTTATT.................................................................2211.001.00-----1.00---------------------------------------------------------------------
.......................................................................................................................................................................ATCTGGGCTATTTTTATTTTTGTTTTTTACAG...................................................321.000.001.00--------------------------------------------------------------------------
...................................GATGATGTGGAAAGGGCTTTGCTTGTCTGCTA.......................................................................................................................................................................................3211.001.00------1.00--------------------------------------------------------------------
......................................................................................................................................................................................ATTTTTGTTTTTTTACAGTGAGATTTTTTTGA....................................3211.001.00-1.00-------------------------------------------------------------------------
................................ATTGATGATGTGGAAA..........................................................................................................................................................................................................1630.670.67-------------------------------0.67-------------------------------------------
....................................................................................GCGGTTTTTGTGGAA.......................................................................................................................................................1520.500.50--------------------------------0.50------------------------------------------
............................................................................................................................................................................................................ATTTTTTTGATCTTCAGCT...........................1920.500.50-----0.50---------------------------------------------------------------------
............................................................................................................................................................................................................ATTTTTTTGATCTTCAGCTA..........................2020.500.50-----0.50---------------------------------------------------------------------
.................................................................................................................................................................................................................TTTGATCTTCAGCTACA........................1730.330.33------------------------------------------------------------------------0.33--
..............................................AAGGGCTTTGCTTGTCTG..........................................................................................................................................................................................1830.330.33---------------------0.33-----------------------------------------------------
.................................TTGATGATGTGGAAAG.........................................................................................................................................................................................................1650.200.20-------------------------------------------------------------------------0.20-
............................................................................................................................................................................................................ATTTTTTTGATCTTCAG.............................1750.200.20-------------------------------0.20-------------------------------------------
..........................................................................................................TTGGAAAGAGAAAAGAAA..............................................................................................................................1860.170.17--------------------------------------------------------------------------0.17
..............................................................................................................................................................................CTATTTTTATTTTTGTTTTT........................................................2090.110.110.11--------------------------------------------------------------------------

Antisense strand
CCTCTCTACTTCCTCGTGTATTTTTAAGATTGATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAAACTTTATCCTTGCGGTTTTTGTGGAAACTGCTTTTGGAAAGAGAAAAGAAATGAACTTTACTGACTTGACATTTTTGCACCTCCCGTTTTTCTAATCTGGGCTATTTTTATTTTTGTTTTTTTACAGTGAGATTTTTTTGATCTTCAGCTACAGTAAGTTATTCCAATTTTTTTTTA
............................................................................................................((((((((...(((((((................)))))))....))).....)))))....................................................................................
............................................................................................................109......................................................................182..................................................................
SizePerfect hitTotal NormPerfect NormSRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		SRR387909(GSM843861)
specific-host: Homo sapienshost cell line: Su. (cell line)		SRR039623(GSM531986)
HCV(+) HCC Tissue Sample. (liver)		GSM359208(GSM359208)
hepg2_bindASP_hl_2. (cell line)		SRR189784DRR001486(DRX001040)
"Hela long cytoplasmic cell fraction, LNA(+)". (hela)		SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)		SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)		SRR039622(GSM531985)
HCV(+) Adjacent Tissue Sample. (liver)		SRR207110(GSM721072)
Nuclear RNA. (cell line)		SRR189786SRR553572(SRX182778)
source: Frontal Cortex. (Frontal Cortex)		RoviraIPAgo2(Rovira)
total RNA. (ago2 breast)		GSM450607(GSM450607)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR342894(SRX096790)
small RNA seq of Right atrial tissue. (heart)		SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)		DRR001489(DRX001043)
"Hela short nuclear cell fraction, control". (hela)		SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)		SRR189782DRR001482(DRX001036)
"Hela long total cell fraction, control". (hela)		SRR039616(GSM531979)
HBV(+) Distal Tissue Sample 1. (liver)		SRR037935(GSM510473)
293cand3. (cell line)		SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)		SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)		SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)		SRR207116(GSM721078)
Nuclear RNA. (cell line)		SRR039624(GSM531987)
HBV(-) HCV(-) Adjacent Tissue Sample. (liver)		SRR033711(GSM497056)
GCB DLBCL (GCB110). (B cell)		SRR330874(SRX091712)
tissue: skin psoriatic involveddisease state:. (skin)		SRR189777(GSM714637)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR342899(SRX096795)
small RNA seq of Left atrial tissue. (heart)		SRR330889(SRX091727)
tissue: skin psoriatic uninvolveddisease stat. (skin)		DRR001488(DRX001042)
"Hela short nuclear cell fraction, LNA(+)". (hela)		SRR330865(SRX091703)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330905(SRX091743)
tissue: normal skindisease state: normal. (skin)		SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)		SRR037936(GSM510474)
293cand1. (cell line)		SRR330879(SRX091717)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)		SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)		SRR039625(GSM531988)
HBV(-) HCV(-) HCC Tissue Sample. (liver)		SRR330913(SRX091751)
tissue: normal skindisease state: normal. (skin)		SRR553575(SRX182781)
source: Kidney. (Kidney)		SRR189787SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)		SRR553573(SRX182779)
source: Cerebellum. (Cerebellum)		SRR330864(SRX091702)
tissue: skin psoriatic involveddisease state:. (skin)		SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)		SRR189785SRR060982(GSM569186)
Human centrocyte [09-001]. (cell line)		SRR033726(GSM497071)
Mututated CLL (CLLM633). (B cell)		SRR039612(GSM531975)
Human Normal Liver Tissue Sample 2. (liver)		TAX577741(Rovira)
total RNA. (breast)		SRR040025(GSM532910)
G613T. (cervix)		SRR330871(SRX091709)
tissue: skin psoriatic involveddisease state:. (skin)		SRR330861(SRX091699)
tissue: skin psoriatic involveddisease state:. (skin)		SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)		GSM956925AGO2Paz8(GSM956925)
"cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line)		GSM1105750AGO3(GSM1105750)
small RNA sequencing data. (ago3 hela)		SRR060168(GSM565978)
5-8F_nucleus. (cell line)		GSM450602(GSM450602)
miRNA sequencing raw reads from post-mortem s. (brain)		SRR330869(SRX091707)
tissue: skin psoriatic involveddisease state:. (skin)		SRR189776(GSM714636)
cell line: HEK293clip variant: CLIPenzymatic . (cell line)		SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)		SRR330916(SRX091754)
tissue: normal skindisease state: normal. (skin)		SRR330886(SRX091724)
tissue: skin psoriatic uninvolveddisease stat. (skin)		TAX577745(Rovira)
total RNA. (breast)		SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)		SRR207119(GSM721081)
XRN1&2 knockdown. (XRN1/XRN2 cell line)		DRR000559(DRX000317)
"THP-1 whole cell RNA, no treatment". (cell line)		SRR330859(SRX091697)
tissue: skin psoriatic involveddisease state:. (skin)		SRR040031(GSM532916)
G013T. (cervix)
....................................................................................................................AAAAGAAATGAACTTTGTCT.................................................................................................................. 201.000.00--1.00------------------------------------------------------------------------
......................................................................................................................................................................................................AGTGAGATTTTTTTGCT................................... 171.000.00-------1.00-------------------------------------------------------------------
......................................................................................................................................................................................................AGTGAGATTTTTTTGTTC.................................. 181.000.00---------------------1.00-----------------------------------------------------
..............................................................................................................AAAGAGAAAAGAAATGTTG......................................................................................................................... 191.000.00-----------------------------------------------------------------1.00---------
..............................................................................................................AAAGAGAAAAGAAATGTTTG........................................................................................................................ 201.000.00------------------------------------------------------------------1.00--------