| (1) AGO2.ip | (2) B-CELL | (2) BRAIN | (10) BREAST | (11) CELL-LINE | (8) CERVIX | (2) HEART | (2) HELA | (2) LIVER | (3) OTHER | (15) SKIN | (1) UTERUS |
| CGACAGCGAGTACTGGGTCCTGGGCCCCACGCGCTACAGCTGGAAGAAAGGTGACCGTCCAGGCTGGCCTCCTGGAGGCCTCTCCTCTGCAGCACAGTGGGCTGCCGCGGTCGGGCTTTGGGGCAGACGGCAGGAGGGACCTTCCGGGGTGGTGGCTGCCACTGGAGTCTAGCAGGCAAGGAGGGGAGCCCGTGGGAGCCCCCATCCCGGCAGCCCTGAACTCCCTTTCCCATCCCCCTGCGCCTCTGGAGCGGGAGCTGGAGCTGCATTCCTGGGGGCCGAGCTCACCGCCTGGGCCCAGAACATTCTTATCTTTCCGTGGCTGCGGCCGAGGGCGGCTCCGCGGCTGCGCTCCAGCAGATACACCGGGCCTCGGGGAGCTGGCCCACGGGCGGCGGGGCTGGGCCCGGGGCTCCCAGGCGCTGACCCCCGGGGCCCGCAGGCGTGTGGCTCACGGACCTGGTGCACGTGGCGGCCCACGAGATCGGCCAC ............................................................(((....)))((((((((.((((((...(((((.......))))).((.(((..(((....))).))).)).)))))).))).)))))........................................................................................................................................................................................................................................................................................................................................................ ..................................................51.................................................................................................150.................................................................................................................................................................................................................................................................................................................................................... | Size | Perfect hit | Total Norm | Perfect Norm | DRR001488(DRX001042) "Hela short nuclear cell fraction, LNA(+)". (hela) | DRR001489(DRX001043) "Hela short nuclear cell fraction, control". (hela) | SRR189785 | SRR326279(GSM769509) cytoplasmic fraction was isolated using PARIS. (cell line) | TAX577740(Rovira) total RNA. (breast) | SRR330902(SRX091740) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR189784 | GSM532876(GSM532876) G547T. (cervix) | SRR553572(SRX182778) source: Frontal Cortex. (Frontal Cortex) | SRR033715(GSM497060) Mantle Cell Lymphoma (Mino122). (B cell) | TAX577744(Rovira) total RNA. (breast) | SRR326281(GSM769511) "Dicer mRNA was knocked down using siDicer, c. (cell line) | TAX577738(Rovira) total RNA. (breast) | SRR330870(SRX091708) tissue: skin psoriatic involveddisease state:. (skin) | SRR189779(GSM714639) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330908(SRX091746) tissue: normal skindisease state: normal. (skin) | SRR330867(SRX091705) tissue: skin psoriatic involveddisease state:. (skin) | SRR330905(SRX091743) tissue: normal skindisease state: normal. (skin) | SRR330912(SRX091750) tissue: normal skindisease state: normal. (skin) | GSM532877(GSM532877) G691N. (cervix) | TAX577580(Rovira) total RNA. (breast) | SRR191598(GSM715708) 79genomic small RNA (size selected RNA from t. (breast) | SRR094130(GSM651906) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR040037(GSM532922) G243T. (cervix) | SRR040028(GSM532913) G026N. (cervix) | DRR000557(DRX000315) "THP-1 whole cell RNA, after 3 day treatment . (cell line) | SRR343336 | SRR033724(GSM497069) L428 cell line (L428). (B cell) | GSM532874(GSM532874) G699T. (cervix) | SRR189782 | SRR037937(GSM510475) 293cand2. (cell line) | SRR039617(GSM531980) HBV(+) Adjacent Tissue Sample 1. (liver) | SRR040008(GSM532893) G727N. (cervix) | GSM450603(GSM450603) miRNA sequencing raw reads from post-mortem s. (brain) | SRR330899(SRX091737) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR191548(GSM715658) 101genomic small RNA (size selected RNA from . (breast) | GSM450599(GSM450599) miRNA sequencing raw reads from post-mortem s. (brain) | GSM956925Ago2PAZ(GSM956925) "cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line) | SRR326280(GSM769510) total cell content of unperturbed cells was s. (cell line) | SRR191460(GSM715570) 33genomic small RNA (size selected RNA from t. (breast) | SRR060981(GSM569185) Human centroblast [09-001]. (cell line) | SRR189777(GSM714637) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330879(SRX091717) tissue: skin psoriatic involveddisease state:. (skin) | SRR342894(SRX096790) small RNA seq of Right atrial tissue. (heart) | SRR330907(SRX091745) tissue: normal skindisease state: normal. (skin) | SRR039190(GSM494809) PBMCs were isolated by ficoll gradient from t. (blood) | GSM532883(GSM532883) G871N. (cervix) | SRR330863(SRX091701) tissue: skin psoriatic involveddisease state:. (skin) | SRR553573(SRX182779) source: Cerebellum. (Cerebellum) | SRR191494(GSM715604) 157genomic small RNA (size selected RNA from . (breast) | SRR330894(SRX091732) tissue: skin psoriatic uninvolveddisease stat. (skin) | GSM956925Paz8D5(GSM956925) "cell line: HEK293 cell linepassages: 15-20ip. (cell line) | SRR330903(SRX091741) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330884(SRX091722) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR039611(GSM531974) Human Normal Liver Tissue Sample 1. (liver) | SRR330883(SRX091721) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR107296(GSM677703) 18-30nt fraction of small RNA. (cell line) | SRR191592(GSM715702) 59genomic small RNA (size selected RNA from t. (breast) | TAX577746(Rovira) total RNA. (breast) | GSM532871(GSM532871) G652N. (cervix) | SRR553574(SRX182780) source: Heart. (Heart) | SRR330878(SRX091716) tissue: skin psoriatic involveddisease state:. (skin) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ................................................................................................................GGGCTTTGGGGCAGAAAGG......................................................................................................................................................................................................................................................................................................................................................................... | 19 | 30.00 | 0.00 | 18.00 | 12.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ................................................................................................................GGGCTTTGGGGCAGAAAGC......................................................................................................................................................................................................................................................................................................................................................................... | 19 | 6.00 | 0.00 | 2.00 | 4.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................................................................................................................................................................GCGGGGCTGGGCCCGCGCC............................................................................... | 19 | 5.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | 1.00 | - | 1.00 | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ................................................................................................................GGGCTTTGGGGCAGAAGGC......................................................................................................................................................................................................................................................................................................................................................................... | 19 | 5.00 | 0.00 | 2.00 | 3.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................................................................................................................................................................GCGGGGCTGGGCCCGCGC................................................................................ | 18 | 4.00 | 0.00 | - | - | - | - | - | - | - | - | 2.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................................................................................................................................................................GCGGGGCTGGGCCCGCG................................................................................. | 17 | 3.00 | 0.00 | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | 1.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................CGGTCGGGCTTTGGGGCTCTG............................................................................................................................................................................................................................................................................................................................................................................ | 21 | 2.00 | 0.00 | - | - | - | - | - | 2.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ........................................................................................................................................................................................................................................................GAGCGGGAGCTGGAGCCG.................................................................................................................................................................................................................................. | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .................................................................................................................................................................................................................................................................................................................................GCTGCGGCCGAGGGCCCGC........................................................................................................................................................ | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................GCGCTACAGCTGGAATTGG........................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................AGCAGGCAAGGAGGGCTTC............................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .....................................................................................................................................................................................................................................................................................................................................................................................................................................GCTGACCCCCGGGGCGGGC.................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .................................................................................................................................................................................................................................................................................................................................................................................GCCTCGGGGAGCTGGCAG......................................................................................................... | 18 | 1.00 | 0.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................GCGGGAGCTGGAGCTGGGGC.............................................................................................................................................................................................................................. | 20 | 1.00 | 0.00 | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .....................................................................................................................................................................................................................................................................................................................................................................................................GGGCGGCGGGGCTGGGTG..................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ......................................................................................................................................................................................................................................................TGGAGCGGGAGCTGGGAT.................................................................................................................................................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................................................................................................................................................................................................CCCCCGGGGCCCGCAGCCGT.............................................. | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .................................................................................................................................................................................................................................................................................................................................................................................................CCACGGGCGGCGGGGGC.......................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................................................................................................................................................................................................................................................................CCTCGGGGAGCTGGCAA......................................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ........................................................GTCCAGGCTGGCCTCCTTTTT............................................................................................................................................................................................................................................................................................................................................................................................................................... | 21 | 1.00 | 0.00 | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................................................................................................................................................................................................................................................................................................................GGCGCTGACCCCCGGGCCTC...................................................... | 20 | 1.00 | 0.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .....................................................................................................CTGCCGCGGTCGGGCCGCT.................................................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................................................................................................................................................................................................................................................................................................................................GGGCTGGGCCCGGGGAT.............................................................................. | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................................................................................................................................................................................................................................................................................................CGGGCGGCGGGGCTGGGC...................................................................................... | 18 | 3 | 1.00 | 1.00 | - | - | - | 0.67 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - | - | - | - | - |
| .....................................................................................................................................................................................................................................................................................................................................................................................................GGGCGGCGGGGCTGGGCAG.................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .....................................................................................................................................................................................................................................................................................................................................................................................................GGGCGGCGGGGCTGGTG...................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ......................................................................................................................................................................................................................................................................................................................................................................................................GGCGGCGGGGCTGGGTG..................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...................CTGGGCCCCACGCGCGCTA...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ................................................................................................................................................................................................................................................................................................................................................................................GGCCTCGGGGAGCTGCCAA......................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................................................................................................................................................................................................................................................................................................CGGGCGGCGGGGCTGGCCGA.................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................................................................................................................................................................................................................................................................................................CGGGCGGCGGGGCTGGTCG..................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...............................................................................................................................................CCGGGGTGGTGGCTGCGGCT......................................................................................................................................................................................................................................................................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................GCCTCCTGGAGGCCTTGTG....................................................................................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .............................................................................................ACAGTGGGCTGCCGCGGTCGGGCC....................................................................................................................................................................................................................................................................................................................................................................................... | 24 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................................................................................................................................................................................................................................................................................................CGGGCGGCGGGGCTGGT....................................................................................... | 17 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..................................................................................................................................................................................................................................................................................................................................................................................CCTCGGGGAGCTGGCAGAC....................................................................................................... | 19 | 1.00 | 0.00 | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .....................................................................................................................................GAGGGACCTTCCGGGGCAG.................................................................................................................................................................................................................................................................................................................................................... | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................................................................................................................................................................................................................................................ACACCGGGCCTCGGGGAGCT.............................................................................................................. | 20 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - |
| ....................................................................................................................................................................................................................................................................................................................TTATCTTTCCGTGGCTGC...................................................................................................................................................................... | 18 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ......................................................................................................................................................................................................................................................................................................................................................................................................................................................................CGGACCTGGTGCACG....................... | 15 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ........................................................................................................CCGCGGTCGGGCTTTGGGGC................................................................................................................................................................................................................................................................................................................................................................................ | 20 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - |
| ................................................................................................................................................................................................................................................CGCCTCTGGAGCGGGAGCTGGAG..................................................................................................................................................................................................................................... | 23 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - |
| ....................................................................................................................................................................................................................................................................................................................................................................................................................................................................CACGGACCTGGTGCACGTGGCGGC................ | 24 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ....AGCGAGTACTGGGTCCTGGGCCCCACGCG........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... | 29 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .....................................................................................................................................................................AGTCTAGCAGGCAAGGAGGGGAGC............................................................................................................................................................................................................................................................................................................... | 24 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ..................................................................................................................................................................................................................................................................................................................................................................................................................................GGCGCTGACCCCCGGGGC........................................................ | 18 | 2 | 0.50 | 0.50 | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ....................................................................................................................................................................................................................................................................................................................................................................................................CGGGCGGCGGGGCTGGG....................................................................................... | 17 | 7 | 0.43 | 0.43 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.14 | 0.14 | 0.14 | - |
| .........................................................................................................................................................................................................................................................................................AGCTCACCGCCTGGG.................................................................................................................................................................................................... | 15 | 3 | 0.33 | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - | - | - | - | - | - | - |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................CGGGGCTGGGCCCGGGGC............................................................................... | 18 | 4 | 0.25 | 0.25 | - | - | - | - | 0.25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .............................................................................................................................................................................................................................................................................................................................CGTGGCTGCGGCCGA................................................................................................................................................................ | 15 | 4 | 0.25 | 0.25 | - | - | - | 0.25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .....................................................................................................................................................................................................................................................CTGGAGCGGGAGCTGGA...................................................................................................................................................................................................................................... | 17 | 5 | 0.20 | 0.20 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.20 | - | - | - | - | - |
| ......................................................................................................................................................................................................................................................TGGAGCGGGAGCTGGAG..................................................................................................................................................................................................................................... | 17 | 6 | 0.17 | 0.17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.17 | - | - | - | - |
| .........................................................................................................................................................................................................................................................AGCGGGAGCTGGAGCTG.................................................................................................................................................................................................................................. | 17 | 8 | 0.12 | 0.12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................CGGGGCTGGGCCCGGG................................................................................. | 16 | 9 | 0.11 | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ..............................................................................................................................................................................................................................................................................CCTGGGGGCCGAGCT............................................................................................................................................................................................................... | 15 | 9 | 0.11 | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.11 |
| CGACAGCGAGTACTGGGTCCTGGGCCCCACGCGCTACAGCTGGAAGAAAGGTGACCGTCCAGGCTGGCCTCCTGGAGGCCTCTCCTCTGCAGCACAGTGGGCTGCCGCGGTCGGGCTTTGGGGCAGACGGCAGGAGGGACCTTCCGGGGTGGTGGCTGCCACTGGAGTCTAGCAGGCAAGGAGGGGAGCCCGTGGGAGCCCCCATCCCGGCAGCCCTGAACTCCCTTTCCCATCCCCCTGCGCCTCTGGAGCGGGAGCTGGAGCTGCATTCCTGGGGGCCGAGCTCACCGCCTGGGCCCAGAACATTCTTATCTTTCCGTGGCTGCGGCCGAGGGCGGCTCCGCGGCTGCGCTCCAGCAGATACACCGGGCCTCGGGGAGCTGGCCCACGGGCGGCGGGGCTGGGCCCGGGGCTCCCAGGCGCTGACCCCCGGGGCCCGCAGGCGTGTGGCTCACGGACCTGGTGCACGTGGCGGCCCACGAGATCGGCCAC ............................................................(((....)))((((((((.((((((...(((((.......))))).((.(((..(((....))).))).)).)))))).))).)))))........................................................................................................................................................................................................................................................................................................................................................ ..................................................51.................................................................................................150.................................................................................................................................................................................................................................................................................................................................................... | Size | Perfect hit | Total Norm | Perfect Norm | DRR001488(DRX001042) "Hela short nuclear cell fraction, LNA(+)". (hela) | DRR001489(DRX001043) "Hela short nuclear cell fraction, control". (hela) | SRR189785 | SRR326279(GSM769509) cytoplasmic fraction was isolated using PARIS. (cell line) | TAX577740(Rovira) total RNA. (breast) | SRR330902(SRX091740) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR189784 | GSM532876(GSM532876) G547T. (cervix) | SRR553572(SRX182778) source: Frontal Cortex. (Frontal Cortex) | SRR033715(GSM497060) Mantle Cell Lymphoma (Mino122). (B cell) | TAX577744(Rovira) total RNA. (breast) | SRR326281(GSM769511) "Dicer mRNA was knocked down using siDicer, c. (cell line) | TAX577738(Rovira) total RNA. (breast) | SRR330870(SRX091708) tissue: skin psoriatic involveddisease state:. (skin) | SRR189779(GSM714639) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330908(SRX091746) tissue: normal skindisease state: normal. (skin) | SRR330867(SRX091705) tissue: skin psoriatic involveddisease state:. (skin) | SRR330905(SRX091743) tissue: normal skindisease state: normal. (skin) | SRR330912(SRX091750) tissue: normal skindisease state: normal. (skin) | GSM532877(GSM532877) G691N. (cervix) | TAX577580(Rovira) total RNA. (breast) | SRR191598(GSM715708) 79genomic small RNA (size selected RNA from t. (breast) | SRR094130(GSM651906) small RNA(18-35nt)small RNA deep sequencing o. (uterus) | SRR040037(GSM532922) G243T. (cervix) | SRR040028(GSM532913) G026N. (cervix) | DRR000557(DRX000315) "THP-1 whole cell RNA, after 3 day treatment . (cell line) | SRR343336 | SRR033724(GSM497069) L428 cell line (L428). (B cell) | GSM532874(GSM532874) G699T. (cervix) | SRR189782 | SRR037937(GSM510475) 293cand2. (cell line) | SRR039617(GSM531980) HBV(+) Adjacent Tissue Sample 1. (liver) | SRR040008(GSM532893) G727N. (cervix) | GSM450603(GSM450603) miRNA sequencing raw reads from post-mortem s. (brain) | SRR330899(SRX091737) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR191548(GSM715658) 101genomic small RNA (size selected RNA from . (breast) | GSM450599(GSM450599) miRNA sequencing raw reads from post-mortem s. (brain) | GSM956925Ago2PAZ(GSM956925) "cell line: HEK293 cell linepassages: 15-20ip. (ago2 cell line) | SRR326280(GSM769510) total cell content of unperturbed cells was s. (cell line) | SRR191460(GSM715570) 33genomic small RNA (size selected RNA from t. (breast) | SRR060981(GSM569185) Human centroblast [09-001]. (cell line) | SRR189777(GSM714637) cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line) | SRR330879(SRX091717) tissue: skin psoriatic involveddisease state:. (skin) | SRR342894(SRX096790) small RNA seq of Right atrial tissue. (heart) | SRR330907(SRX091745) tissue: normal skindisease state: normal. (skin) | SRR039190(GSM494809) PBMCs were isolated by ficoll gradient from t. (blood) | GSM532883(GSM532883) G871N. (cervix) | SRR330863(SRX091701) tissue: skin psoriatic involveddisease state:. (skin) | SRR553573(SRX182779) source: Cerebellum. (Cerebellum) | SRR191494(GSM715604) 157genomic small RNA (size selected RNA from . (breast) | SRR330894(SRX091732) tissue: skin psoriatic uninvolveddisease stat. (skin) | GSM956925Paz8D5(GSM956925) "cell line: HEK293 cell linepassages: 15-20ip. (cell line) | SRR330903(SRX091741) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR330884(SRX091722) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR039611(GSM531974) Human Normal Liver Tissue Sample 1. (liver) | SRR330883(SRX091721) tissue: skin psoriatic uninvolveddisease stat. (skin) | SRR107296(GSM677703) 18-30nt fraction of small RNA. (cell line) | SRR191592(GSM715702) 59genomic small RNA (size selected RNA from t. (breast) | TAX577746(Rovira) total RNA. (breast) | GSM532871(GSM532871) G652N. (cervix) | SRR553574(SRX182780) source: Heart. (Heart) | SRR330878(SRX091716) tissue: skin psoriatic involveddisease state:. (skin) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ..........................................................................................AGCACAGTGGGCTGCCGTTA.............................................................................................................................................................................................................................................................................................................................................................................................. | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ................................................................................................................................................................................................................................................................................TGGGGGCCGAGCTCACAA.......................................................................................................................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................CGGGGCTGGGCCCGGGGGGA............................................................................. | 20 | 9 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .....................................................................................................................................................................................................................................................................................................................................CGGCCGAGGGCGGCTACC..................................................................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .........................................................................................................................................................................................................................................................................................................CCAGAACATTCTTATCCCA................................................................................................................................................................................ | 19 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| .................................................................................................................................................................................................................................TTTCCCATCCCCCTGAAA......................................................................................................................................................................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................................................................................................................................................................................................................................................................................ACCGCCTGGGCCCAGATGGA.......................................................................................................................................................................................... | 20 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ...................................................................................................................................................................................................................................................................................................................................................................................CTCGGGGAGCTGGCCTGG....................................................................................................... | 18 | 1.00 | 0.00 | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ....................................................................................................................................................................................................................................................................................................................................................................................................................GCCCGGGGCTCCCAGGCG...................................................................... | 18 | 1.00 | 0.00 | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................................................................................CAGTGGGCTGCCGCGG.............................................................................................................................................................................................................................................................................................................................................................................................. | 16 | 1.00 | 0.00 | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..............................................................................................................................................................................................................................................................................................................................................................GCTCCAGCAGATACAAGC............................................................................................................................ | 18 | 1.00 | 0.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 1.00 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| ..........................................................................................................................................CCACCACCCCGGAAGGT................................................................................................................................................................................................................................................................................................................................................. | 17 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ..................................................................................................................................................................................................................................................................GCCCCCAGGAATGCAGCTCCA..................................................................................................................................................................................................................... | 21 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...................................................................................................................................CCCCGGAAGGTCCCTCCT....................................................................................................................................................................................................................................................................................................................................................... | 18 | 2 | 0.50 | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .............................TCCAGCTGTAGCGCG................................................................................................................................................................................................................................................................................................................................................................................................................................................................ | 15 | 3 | 0.33 | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| .........................................................................................................................................................................................................AGGGCTGCCGGGATGG................................................................................................................................................................................................................................................................................... | 16 | 3 | 0.33 | 0.33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.33 | - | - | - | - | - | - | - | - |
| ........................................................................................................................................................................................................................................CCAGAGGCGCAGGGGGA................................................................................................................................................................................................................................................... | 17 | 4 | 0.25 | 0.25 | - | - | - | - | - | 0.25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ................................................................................................................................................................................................................................................................................................GTTCTGGGCCCAGGCG............................................................................................................................................................................................ | 16 | 4 | 0.25 | 0.25 | - | 0.25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................CGCCACGTGCACCAG.................. | 15 | 5 | 0.20 | 0.20 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0.20 | - | - | - | - | - | - |
| ......................................................................................................................................................................................................................................................................................................................................................................................................................GCCTGGGAGCCCCGG....................................................................... | 15 | 9 | 0.11 | 0.11 | - | - | - | 0.11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |