ID: uc002gct.0
GENE: FAM64A
chr17:6347759-6348008+


(2)
AGO2.ip
(24)
B-CELL
(10)
BRAIN
(13)
BREAST
(56)
CELL-LINE
(3)
CERVIX
(1)
HEART
(5)
HELA
(5)
LIVER
(2)
OTHER
(2)
RRP40.ip
(8)
SKIN
(3)
UTERUS
(1)
XRN.ip

Sense strand
TGGGCGAGGAGCAGCTGTGCTGCGGCTGTGCTCGGCCTTAGTGGTGTCGGGTGAGTGCGGGCTGGGCACAAGTTTCGCCCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTGGACTCAAAACAATTTTTTTGTTCGGAGGGGAGGGCATCAGGTTCTGTTCACAGGGGAGGGCATCAGGTTCGGACACGCACGGCCTGTGGGGTCGTCTGGGTACCACAAGAAGTCGGATCGAAATCGGGGCGTCTG
.........................................................(((.(((((((((((.......))))).)))))).)))..((((....)))).............................................................................................................................................
..................................................51.............................................................114......................................................................................................................................
SizePerfect hitTotal NormPerfect NormGSM339994(GSM339994)
hues6. (cell line)
SRR033718(GSM497063)
Multiple Myeloma (U266). (B cell)
GSM339995(GSM339995)
hues6NP. (cell line)
SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR038863(GSM458546)
MM603. (cell line)
SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR207110(GSM721072)
Nuclear RNA. (cell line)
SRR037937(GSM510475)
293cand2. (cell line)
SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)
SRR060168(GSM565978)
5-8F_nucleus. (cell line)
SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)
SRR207112(GSM721074)
RRP40 knockdown. (RRP40 cell line)
SRR033728(GSM497073)
MALT (MALT413). (B cell)
SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)
SRR029125(GSM416754)
U2OS. (cell line)
SRR038857(GSM458540)
D20. (cell line)
SRR189782SRR207111(GSM721073)
Whole cell RNA. (cell line)
DRR001489(DRX001043)
"Hela short nuclear cell fraction, control". (hela)
SRR060169(GSM565979)
5-8F_cytoplasm. (cell line)
SRR015359(GSM380324)
Germinal Center B cell (GC136). (B cell)
SRR015361(GSM380326)
Memory B cells (MM55). (B cell)
SRR039625(GSM531988)
HBV(-) HCV(-) HCC Tissue Sample. (liver)
SRR038852(GSM458535)
QF1160MB. (cell line)
SRR015360(GSM380325)
Plasma B cells (PC137). (B cell)
SRR033716(GSM497061)
Mentle Cell Lymphoma (MCL114). (B cell)
SRR037939(GSM510477)
293cand5_rep1. (cell line)
SRR033731(GSM497076)
h929 Cell line (h929). (B cell)
SRR037940(GSM510478)
293cand5_rep2. (cell line)
SRR038858(GSM458541)
MEL202. (cell line)
SRR189786SRR094129(GSM651905)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)
SRR039619(GSM531982)
HBV(+) HCC Tissue Sample 1. (liver)
SRR038859(GSM458542)
MM386. (cell line)
SRR390723(GSM850202)
total small RNA. (cell line)
GSM450608(GSM450608)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR015365(GSM380330)
Memory B cells (MM139). (B cell)
SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)
SRR387910(GSM843862)
antibody for ip: Ago2. (ago2 cell line)
DRR001488(DRX001042)
"Hela short nuclear cell fraction, LNA(+)". (hela)
SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)
SRR033719(GSM497064)
6hr Activated B cell line (ABC158). (B cell)
SRR189784SRR038854(GSM458537)
MM653. (cell line)
SRR033730(GSM497075)
Lymphoblastic (ALL411). (B cell)
SRR033714(GSM497059)
Burkitt Lymphoma (BL134). (B cell)
SRR038861(GSM458544)
MM466. (cell line)
SRR039191(GSM494810)
PBMCs were isolated by ficoll gradient from t. (blood)
SRR037938(GSM510476)
293Red. (cell line)
SRR326280(GSM769510)
total cell content of unperturbed cells was s. (cell line)
SRR033720(GSM497065)
EBV activated B cell line (EBV159). (B cell)
TAX577740(Rovira)
total RNA. (breast)
SRR387909(GSM843861)
specific-host: Homo sapienshost cell line: Su. (cell line)
GSM450598(GSM450598)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR037933(GSM510471)
293cand4_rep2. (cell line)
SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)
SRR189787SRR038860(GSM458543)
MM426. (cell line)
SRR033712(GSM497057)
Burkitt Lymphoma (BL510). (B cell)
GSM450602(GSM450602)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR037942(GSM510480)
293DroshaTN_cand5. (cell line)
SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)
SRR037943(GSM510481)
293DcrTN. (cell line)
SRR207116(GSM721078)
Nuclear RNA. (cell line)
GSM450610(GSM450610)
miRNA sequencing raw reads from post-mortem s. (brain)
TAX577742(Rovira)
total RNA. (breast)
SRR033729(GSM497074)
splenic MZL (Splenic414). (B cell)
SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)
GSM339996(GSM339996)
hues6Neuron. (cell line)
SRR033725(GSM497070)
Unmutated CLL (CLLU626). (B cell)
SRR444049(SRX128897)
Sample 9cDNABarcode: AF-PP-334: ACG CTC TTC C. (skin)
SRR033726(GSM497071)
Mututated CLL (CLLM633). (B cell)
SRR040028(GSM532913)
G026N. (cervix)
SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)
GSM450600(GSM450600)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR330867(SRX091705)
tissue: skin psoriatic involveddisease state:. (skin)
SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)
TAX577739(Rovira)
total RNA. (breast)
SRR039613(GSM531976)
Human Normal Liver Tissue Sample 3. (liver)
SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)
SRR037934(GSM510472)
293cand4_rep3. (cell line)
TAX577741(Rovira)
total RNA. (breast)
SRR390724(GSM850203)
small rna immunoprecipitated. (cell line)
SRR326282(GSM769512)
"Dicer mRNA was knocked down using siDicer, t. (cell line)
GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR330890(SRX091728)
tissue: skin psoriatic uninvolveddisease stat. (skin)
GSM1105749AGO2(GSM1105749)
small RNA sequencing data. (ago2 hela)
SRR040022(GSM532907)
G575N. (cervix)
SRR033732(GSM497077)
bjab cell line (bjab103). (B cell)
SRR037936(GSM510474)
293cand1. (cell line)
SRR015446(SRR015446)
smallRNAs high-throughput sequencing Total. (breast)
SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)
TAX577590(Rovira)
total RNA. (breast)
SRR191492(GSM715602)
154genomic small RNA (size selected RNA from . (breast)
SRR342897(SRX096793)
small RNA seq of Left atrial tissue. (heart)
SRR060986(GSM569190)
Human memory B cell [09-001]. (cell line)
GSM450609(GSM450609)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM450605(GSM450605)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM1105753INPUT(GSM1105753)
small RNA sequencing data. (hela)
SRR038856(GSM458539)
D11. (cell line)
SRR107297(GSM677704)
18-30nt fraction of small RNA. (cell line)
SRR038862(GSM458545)
MM472. (cell line)
SRR207118(GSM721080)
RRP40 knockdown. (RRP40 cell line)
TAX577588(Rovira)
total RNA. (breast)
SRR037935(GSM510473)
293cand3. (cell line)
SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)
DRR001486(DRX001040)
"Hela long cytoplasmic cell fraction, LNA(+)". (hela)
SRR039635(GSM518472)
THP1_nuc_sRNAs. (cell line)
SRR191421(GSM715531)
122genomic small RNA (size selected RNA from . (breast)
SRR015448(SRR015448)
cytoplasmic small RNAs. (breast)
SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)
SRR037944(GSM510482)
293DcrTN_cand5. (cell line)
SRR029126(GSM416755)
143B. (cell line)
SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)
SRR191562(GSM715672)
82genomic small RNA (size selected RNA from t. (breast)
SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)
SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)
SRR330904(SRX091742)
tissue: normal skindisease state: normal. (skin)
SRR015358(GSM380323)
NaÌøve B Cell (Naive39). (B cell)
SRR094130(GSM651906)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)
SRR330868(SRX091706)
tissue: skin psoriatic involveddisease state:. (skin)
SRR189785SRR330897(SRX091735)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR038855(GSM458538)
D10. (cell line)
TAX577579(Rovira)
total RNA. (breast)
TAX577743(Rovira)
total RNA. (breast)
SRR039192(GSM494811)
K562 cell line is derived from a CML patient . (cell line)
SRR040031(GSM532916)
G013T. (cervix)
SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)
GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM450604(GSM450604)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR060982(GSM569186)
Human centrocyte [09-001]. (cell line)
SRR330880(SRX091718)
tissue: skin psoriatic involveddisease state:. (skin)
...................................................TGAGTGCGGGCTGGGCACAAGT.................................................................................................................................................................................221138.00138.0035.0018.0023.00-10.00--2.003.003.001.00-1.001.007.001.002.00-3.002.00--6.002.00-1.00----1.00-2.001.00------1.00-1.001.001.00----------1.00------1.00---1.00-2.00-----------------------1.00-----------1.00------------1.00--1.00--------------
..................................................GTGAGTGCGGGCTGGGCACAAGT.................................................................................................................................................................................23165.0065.008.004.007.00-1.00--3.001.002.00---5.00--1.00--2.002.00--1.00-1.005.00-4.001.00--1.00-----2.00---1.00-1.00-2.00-3.00-------------1.00---1.00-----------------------1.00--1.00-----------------1.00--1.00----------1.00---------
...................................................TGAGTGCGGGCTGGGCACAAG..................................................................................................................................................................................21126.0026.003.003.00--2.00-----1.002.00----2.00-3.00----2.00---1.00-----------1.00--1.00-----------2.00--1.00----------------------1.00----------------------------------------1.00-------------
...........CAGCTGTGCTGCGGCTCT.............................................................................................................................................................................................................................18121.001.00------------4.00-------1.00---1.00----------3.00-1.00---2.00--------2.001.00-1.00---------------2.00------1.00-----1.00-----1.00----------------------------------------------
............AGCTGTGCTGCGGCTCTC............................................................................................................................................................................................................................1821.000.00----------1.00---------2.00---2.00----------------1.00---2.00----1.00----1.00--2.00-----1.00------1.00--1.00---1.00----------------1.00--------------1.00----------------1.00---1.001.00--
............AGCTGTGCTGCGGCTCT.............................................................................................................................................................................................................................1718.000.00--------------------2.003.00--2.00----------1.00-----------------2.00-----2.00----1.00-------------------1.00-----------1.001.00--1.00------------------1.00---------------
...................................................TGAGTGCGGGCTGGGCACA....................................................................................................................................................................................19114.0014.00--1.00-----1.00--6.00-----3.00---------1.00------1.00----------------------1.00-----------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTT................................................................................................................................................................................23111.0011.00-3.001.00-1.00----1.00---1.00-----1.00---------------------------1.00-----------------1.00--------------------1.00------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAT..................................................................................................................................................................................2219.003.00-------8.001.00------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACA....................................................................................................................................................................................2019.009.001.002.00---------------3.00----------------------------------3.00----------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCAC.....................................................................................................................................................................................1819.009.00--1.00--------1.00-----2.00--------------1.00-----1.00----------------------------------------1.00---1.00--------------1.00------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGA.................................................................................................................................................................................2219.0026.001.001.00--1.00-----1.00-----------1.001.00-------3.00-------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTA................................................................................................................................................................................2318.00138.00-2.00--1.00----1.001.00----------------1.00---------------------------------1.00---------------------------1.00---------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAA...................................................................................................................................................................................2018.008.00-2.00--1.00-----2.00----1.00---------------------------------------------1.00------------------------------------------------------------1.00------------
................................CGGCCTTAGTGGTGTCGGG.......................................................................................................................................................................................................1916.006.00------3.00-----------------------------------------------------2.00------------------------1.00-------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAG..................................................................................................................................................................................2216.006.00-1.00-------1.00-----1.00-----------------------1.00-----------------------------------1.00-----------------------1.00-----------------------------------
............AGCTGTGCTGCGGCTCTCG...........................................................................................................................................................................................................................195.000.00---------------------3.00---------------2.00-------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTAT...............................................................................................................................................................................2415.00138.00--------1.00----------1.00---------1.001.00-----------------------------------------------------------------------------1.00--------------------------
...........CAGCTGTGCTGCGGCTCTCG...........................................................................................................................................................................................................................2015.001.00------------------------------------3.00------------------1.00-------------------------------------------------1.00-----------------------------
...............................TCGGCCTTAGTGGTGTCGGG.......................................................................................................................................................................................................2015.005.00------4.00--------1.00-----------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAA..................................................................................................................................................................................2215.003.00----------2.00----------------1.00------1.00------------1.00---------------------------------------------------------------------------------------
................GTGCTGCGGCTGTGCTCGGC......................................................................................................................................................................................................................2014.004.00------4.00--------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGC.................................................................................................................................................................................2214.0026.00------------------------------1.00-------------------------3.00------------------------------------------------------------------------------
.........................................................................................AGGCTGGAGTGCAATGGCGCGACCC........................................................................................................................................253.000.00---3.00-----------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAA...................................................................................................................................................................................2113.003.001.00-1.00------------------------------1.00-----------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGA.................................................................................................................................................................................2313.006.00---------1.00---------------------------------1.00--------------------------------------------------------------------------------1.00----------
.........................................................................................AGGCTGGAGTGCAATGGCGCGAAA.........................................................................................................................................243.000.00-----------------------------1.00-----------------------------------------------------------------------------------1.00----------------1.00----
...................................................TGAGTGCGGGCTGGGCACCAGT.................................................................................................................................................................................2213.009.00-1.00--------1.00------------------------------------------------------1.00---------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACT....................................................................................................................................................................................1912.009.00--------1.00-------------------------1.00----------------------------------------------------------------------------------------------------
...........CAGCTGTGCTGCGGCTCTAA...........................................................................................................................................................................................................................2012.001.00------------2.00--------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCAC.....................................................................................................................................................................................1912.002.00--------1.00--------------------1.00---------------------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGCA........................................................................................................................................................242.000.00---2.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGAGCGTG....................................................................................................................................................282.000.00---2.00-----------------------------------------------------------------------------------------------------------------------------------
...................................................................................................................................................................................AGGTTCGGACACGCACGG.....................................................1812.002.00-------------------------------------------------2.00-------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCATAAG..................................................................................................................................................................................2112.002.00----------------1.00--------------------------------1.00-------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTAA...............................................................................................................................................................................2412.00138.00-------------1.00---------1.00---------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAATT.................................................................................................................................................................................2212.008.00----------------------------------------------1.001.00---------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGTAT...............................................................................................................................................................................2512.0065.00--------------------------------------------1.00-------------------------------------------------------------1.00----------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTTT...............................................................................................................................................................................2412.002.00-------------------------------1.00-------------------1.00-----------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACATTA.................................................................................................................................................................................2212.0014.00-2.00-------------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGATT...............................................................................................................................................................................2412.0026.00--------------2.00------------------------------------------------------------------------------------------------------------------------
............AGCTGTGCTGCGGCTCTT............................................................................................................................................................................................................................182.000.00---------------------1.00-----------------------1.00-----------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCAT.....................................................................................................................................................................................1812.002.00---------1.00--------------------------------------------1.00--------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCA......................................................................................................................................................................................1712.002.00--------1.00----------------------------------------------------------------------------------1.00-------------------------------------------
...........................GTGCTCGGCCTTAGTGG..............................................................................................................................................................................................................1712.002.00------2.00--------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCAAAA...................................................................................................................................................................................2012.002.00--------1.00------------------------------------------1.00-----------------------------------------------------------------------------------
....................................................GAGTGCGGGCTGGGCACAAGT.................................................................................................................................................................................2112.002.00-1.001.00------------------------------------------------------------------------------------------------------------------------------------
...............................TCGGCCTTAGTGGTGTCGG........................................................................................................................................................................................................1912.002.00------2.00--------------------------------------------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGGG........................................................................................................................................................242.000.00-----2.00---------------------------------------------------------------------------------------------------------------------------------
.........................................................................TTCGCCCTTGTTGCCCAGGCTGGAGAG......................................................................................................................................................272.000.00-----2.00---------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAATTT................................................................................................................................................................................2312.008.00-2.00-------------------------------------------------------------------------------------------------------------------------------------
...........CAGCTGTGCTGCGGCTCC.............................................................................................................................................................................................................................1812.001.00------------------------1.00--------1.00-----------------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCGGAG.........................................................................................................................................................232.000.00---2.00-----------------------------------------------------------------------------------------------------------------------------------
.......................................AGTGGTGTCGGGTGAGTGCGG..............................................................................................................................................................................................2111.001.00------------1.00--------------------------------------------------------------------------------------------------------------------------
......................................................................AGTTTCGCCCTTGTTGCCCAGGCGGAG.........................................................................................................................................................271.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
........................................................................TTTCGCCCTTGTTGCCCAGGCCAG..........................................................................................................................................................241.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACCCGT.................................................................................................................................................................................2311.002.00----------------------------1.00----------------------------------------------------------------------------------------------------------
............AGCTGTGCTGCGGCTCTCA...........................................................................................................................................................................................................................191.000.00------------------------------------1.00--------------------------------------------------------------------------------------------------
.........................................................................TTCGCCCTTGTTGCCCAGGCTGGGG........................................................................................................................................................251.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
........................................................................TTTCGCCCTTGTTGCCCAGGCTGGACGTC.....................................................................................................................................................291.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGAGTGTGC...................................................................................................................................................291.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
.....................................................AGTGCGGGCTGGGCACAAGTT................................................................................................................................................................................2111.001.00-------------------------1.00-------------------------------------------------------------------------------------------------------------
........................................................................TTTCGCCCTTGTTGCCCAGGCTGGGG........................................................................................................................................................261.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTTAAAA............................................................................................................................................................................2711.0011.00-------------------------------------------------------------------------------------------------------1.00-------------------------------
..............................................TCGGGTGAGTGCGGGCTG..........................................................................................................................................................................................1811.001.00-----------------------------------------------------------------------------------------------------------1.00---------------------------
.........................................................................................AGGCTGGAGTGCAATGGCGCGCCCC........................................................................................................................................251.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
................................................GGGTGAGTGCGGGCTGGGCACAAGT.................................................................................................................................................................................2511.001.00------------------------------------------------------------------------------------------------------1.00--------------------------------
...................................................TGAGTGCGGGCTGGGCACAATTA................................................................................................................................................................................2311.008.00---------------------------------1.00-----------------------------------------------------------------------------------------------------
........................................................................TTTCGCCCTTGTTGCCCAGGCTGGCG........................................................................................................................................................261.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCAA.....................................................................................................................................................................................1811.002.00-------------------------1.00-------------------------------------------------------------------------------------------------------------
.......................................................TGCGGGCTGGGCACAA...................................................................................................................................................................................1611.001.00----------------------------------1.00----------------------------------------------------------------------------------------------------
...........CAGCTGTGCTGCGGCT...............................................................................................................................................................................................................................1611.001.00--------1.00------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAT..................................................................................................................................................................................2111.008.00----------------1.00----------------------------------------------------------------------------------------------------------------------
...........................................................GGCTGGGCACAAGTTCTTT............................................................................................................................................................................191.000.00----------------------------------------1.00----------------------------------------------------------------------------------------------
.............................................GTCGGGTGAGTGCGGGCTGG.........................................................................................................................................................................................2011.001.00-------------------------------------------------------------------1.00-------------------------------------------------------------------
...........................................................GGCTGGGCACAAGTTAG..............................................................................................................................................................................171.000.00------------------------------------------------------------------------------------------------------------------------------1.00--------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGAGGGCA....................................................................................................................................................281.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGTTTT..............................................................................................................................................................................2611.001.00----1.00----------------------------------------------------------------------------------------------------------------------------------
...........................................................................................................................ACAATTTTTTTGTTCTTGC............................................................................................................191.000.00---------------------------------------------------------------------------------------------------------------------------------1.00-----
..............................................TCGGGTGAGTGCGGGCTGA.........................................................................................................................................................................................1911.001.00--------------------------------------------------------------------------------------------------------------------------------1.00------
..................................................GTGAGTGCGGGCTGGGCATAG...................................................................................................................................................................................2111.001.00-------------------------------------------------------------------------------------------------------------1.00-------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGTTT...............................................................................................................................................................................2511.001.00-------------------1.00-------------------------------------------------------------------------------------------------------------------
......................................................GTGCGGGCTGGGCACAAGTTT...............................................................................................................................................................................2111.001.00------------1.00--------------------------------------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGAGAGCA....................................................................................................................................................281.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................TGGCGCGATCTGGACTCAAAACA............................................................................................................................2311.001.00---------------------------------------------------------------1.00-----------------------------------------------------------------------
..GGCGAGGAGCAGCTGTGCTG....................................................................................................................................................................................................................................2011.001.00------------------------------------------------------------------------1.00--------------------------------------------------------------
...............................................................................................................................................................................CATCAGGTTCGGACA............................................................1511.001.00----------------------------------------------------------------------1.00----------------------------------------------------------------
...........CAGCTGTGCTGCGGCTCTC............................................................................................................................................................................................................................1911.001.00-------------------------------------1.00-------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCA......................................................................................................................................................................................1811.001.00-------------------------------------------1.00-------------------------------------------------------------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGACGC......................................................................................................................................................261.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
......................................................................................CCCAGGCTGGAGTGCAATGGCGCGAAA.........................................................................................................................................271.000.00-----------------------------------------------------------------------------1.00---------------------------------------------------------
....................................................................................TGCCCAGGCTGGAGTGCAATGGCGCGATCGGC......................................................................................................................................321.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
...............................................................................CTTGTTGCCCAGGCTGGAGTGCTCTG.................................................................................................................................................261.000.00----------------------------------------------------------------------------------------------1.00----------------------------------------
..........................................................................TCGCCCTTGTTGCCCAGGCTGGAGGGC.....................................................................................................................................................271.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
..........................TGTGCTCGGCCTTAGTGGTGTCGGGTG.....................................................................................................................................................................................................2711.001.00------------------1.00--------------------------------------------------------------------------------------------------------------------
.........................................................................TTCGCCCTTGTTGCCCAGGCGGG..........................................................................................................................................................231.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..............................CTCGGCCTTAGTGGTGTCGGG.......................................................................................................................................................................................................2111.001.00---------------------------------------------------------------1.00-----------------------------------------------------------------------
...........CAGCTGTGCTGCGGCTAT.............................................................................................................................................................................................................................1811.001.00--------------------------------------------------------------------------------------------------------------------1.00------------------
...................................CCTTAGTGGTGTCGGGTGA....................................................................................................................................................................................................1911.001.00---------------1.00-----------------------------------------------------------------------------------------------------------------------
.........................................................................................................GCGCGATCTGGACTCAAAACAATTTT.......................................................................................................................2611.001.00---------------------------------------1.00-----------------------------------------------------------------------------------------------
......................................................................AGTTTCGCCCTTGTTGCCCAGGCGGGA.........................................................................................................................................................271.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..................................................................................................................................................................TCACAGGGGAGGGCATCAGGTTC.................................................................2311.001.00---------------------------------------------------------------------------------------------------------------------------1.00-----------
..................................................GTGAGTGCGGGCTGGGCACAAGAA................................................................................................................................................................................2411.006.00---------------1.00-----------------------------------------------------------------------------------------------------------------------
......................................................................AGTTTCGCCCTTGTTGCCCAGGCTGGGG........................................................................................................................................................281.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
......................................................................AGTTTCGCCCTTGTTGCCCAGGCTGGAGAGC.....................................................................................................................................................311.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
...........CAGCTGTGCTGCGGCTC..............................................................................................................................................................................................................................1711.001.00---------------------------------------------------------------------------------1.00-----------------------------------------------------
..............................................................................CCTTGTTGCCCAGGCTGGAGGTC.....................................................................................................................................................231.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
.................................................................................TGTTGCCCAGGCTGGAGTGCAATGGCGACC...........................................................................................................................................301.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
.....................................................................AAGTTTCGCCCTTGTTGCCCAGGCTGGAGGGC.....................................................................................................................................................321.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
.....................................TTAGTGGTGTCGGGTGAA...................................................................................................................................................................................................181.000.00----------------------------------------------------------------------------------------------------------------1.00----------------------
.......................................................TGCGGGCTGGGCACAAGTTT...............................................................................................................................................................................2011.001.00-------------------------------------------------------------------1.00-------------------------------------------------------------------
..............................................................................CCTTGTTGCCCAGGCTGGAGTTTAG...................................................................................................................................................251.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCAT.....................................................................................................................................................................................1911.001.00-------------------------1.00-------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACACGTT................................................................................................................................................................................2311.0014.00-1.00-------------------------------------------------------------------------------------------------------------------------------------
.................................................GGTGAGTGCGGGCTGGGCAC.....................................................................................................................................................................................2011.001.00-----------------------------------------------------------------------------------------------------1.00---------------------------------
....................TGCGGCTGTGCTCGGTC.....................................................................................................................................................................................................................171.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
.........................................................................................AGGCTGGAGTGCAATGGCGCGATCCAC......................................................................................................................................271.000.00------------------------------1.00--------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGTAA...............................................................................................................................................................................2511.0065.00-------------------------------------------------------------------------------------------------------------------------------------1.00-
...................................CCTTAGTGGTGTCGGGTGAG...................................................................................................................................................................................................2011.001.00-------------1.00-------------------------------------------------------------------------------------------------------------------------
...............TGTGCTGCGGCTGTGTGC.........................................................................................................................................................................................................................181.000.00---------------------------------------------------------------------------------------1.00-----------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGAAA...............................................................................................................................................................................2411.0026.00---------------1.00-----------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAAGTTA...............................................................................................................................................................................2411.0011.00---------------------------1.00-----------------------------------------------------------------------------------------------------------
.....................................................AGTGCGGGCTGGGCACAAG..................................................................................................................................................................................1911.001.00---------------------------------------------------------1.00-----------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCATT....................................................................................................................................................................................1911.002.00----------------------------------------1.00----------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACG....................................................................................................................................................................................1911.009.00----------------1.00----------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCACAT...................................................................................................................................................................................2011.0014.00---------------1.00-----------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGC.................................................................................................................................................................................2311.006.00-------1.00-------------------------------------------------------------------------------------------------------------------------------
..................................................GTGAGTGCGGGCTGGGCACAAGTT................................................................................................................................................................................2411.001.00--1.00------------------------------------------------------------------------------------------------------------------------------------
...................................................TGAGTGCGGGCTGGGCAAAGA..................................................................................................................................................................................2111.002.00-------------------------1.00-------------------------------------------------------------------------------------------------------------
......................................................................AGTTTCGCCCTTGTTGCCCAGGCTGGAGGGA.....................................................................................................................................................311.000.00-----1.00---------------------------------------------------------------------------------------------------------------------------------
.............................................................................CCCTTGTTGCCCAGGCTGGAGGAC.....................................................................................................................................................241.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
........................................................................................................GGCGCGATCTGGACTCAA................................................................................................................................1820.500.50------------------0.50--------------------------------------------------------------------------------------------------------------------
.................................................................................................................................................................................TCAGGTTCGGACAC...........................................................1430.330.33----------------------------------------------------------------------0.33----------------------------------------------------------------
.................................................................................................................................................................................TCAGGTTCGGACA............................................................1340.250.25----------------------------------------------------------------------0.25----------------------------------------------------------------
.....................................................................AAGTTTCGCCCTTGTTGCCCAGGCTGG..........................................................................................................................................................2750.200.20---0.20-----------------------------------------------------------------------------------------------------------------------------------
................................CGGCCTTAGTGGT.............................................................................................................................................................................................................1390.110.11--------------------------------------------------------------------------------------------------------------------------------------0.11

Antisense strand
TGGGCGAGGAGCAGCTGTGCTGCGGCTGTGCTCGGCCTTAGTGGTGTCGGGTGAGTGCGGGCTGGGCACAAGTTTCGCCCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTGGACTCAAAACAATTTTTTTGTTCGGAGGGGAGGGCATCAGGTTCTGTTCACAGGGGAGGGCATCAGGTTCGGACACGCACGGCCTGTGGGGTCGTCTGGGTACCACAAGAAGTCGGATCGAAATCGGGGCGTCTG
.........................................................(((.(((((((((((.......))))).)))))).)))..((((....)))).............................................................................................................................................
..................................................51.............................................................114......................................................................................................................................
SizePerfect hitTotal NormPerfect NormGSM339994(GSM339994)
hues6. (cell line)
SRR033718(GSM497063)
Multiple Myeloma (U266). (B cell)
GSM339995(GSM339995)
hues6NP. (cell line)
SRR189780(GSM714640)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR038863(GSM458546)
MM603. (cell line)
SRR189779(GSM714639)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR207110(GSM721072)
Nuclear RNA. (cell line)
SRR037937(GSM510475)
293cand2. (cell line)
SRR107296(GSM677703)
18-30nt fraction of small RNA. (cell line)
SRR060168(GSM565978)
5-8F_nucleus. (cell line)
SRR033717(GSM497062)
Mentle Cell Lymphoma (MCL112). (B cell)
SRR207112(GSM721074)
RRP40 knockdown. (RRP40 cell line)
SRR033728(GSM497073)
MALT (MALT413). (B cell)
SRR033715(GSM497060)
Mantle Cell Lymphoma (Mino122). (B cell)
SRR029125(GSM416754)
U2OS. (cell line)
SRR038857(GSM458540)
D20. (cell line)
SRR189782SRR207111(GSM721073)
Whole cell RNA. (cell line)
DRR001489(DRX001043)
"Hela short nuclear cell fraction, control". (hela)
SRR060169(GSM565979)
5-8F_cytoplasm. (cell line)
SRR015359(GSM380324)
Germinal Center B cell (GC136). (B cell)
SRR015361(GSM380326)
Memory B cells (MM55). (B cell)
SRR039625(GSM531988)
HBV(-) HCV(-) HCC Tissue Sample. (liver)
SRR038852(GSM458535)
QF1160MB. (cell line)
SRR015360(GSM380325)
Plasma B cells (PC137). (B cell)
SRR033716(GSM497061)
Mentle Cell Lymphoma (MCL114). (B cell)
SRR037939(GSM510477)
293cand5_rep1. (cell line)
SRR033731(GSM497076)
h929 Cell line (h929). (B cell)
SRR037940(GSM510478)
293cand5_rep2. (cell line)
SRR038858(GSM458541)
MEL202. (cell line)
SRR189786SRR094129(GSM651905)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)
SRR039619(GSM531982)
HBV(+) HCC Tissue Sample 1. (liver)
SRR038859(GSM458542)
MM386. (cell line)
SRR390723(GSM850202)
total small RNA. (cell line)
GSM450608(GSM450608)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR015365(GSM380330)
Memory B cells (MM139). (B cell)
SRR039190(GSM494809)
PBMCs were isolated by ficoll gradient from t. (blood)
SRR387910(GSM843862)
antibody for ip: Ago2. (ago2 cell line)
DRR001488(DRX001042)
"Hela short nuclear cell fraction, LNA(+)". (hela)
SRR094132(GSM651908)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)
SRR033719(GSM497064)
6hr Activated B cell line (ABC158). (B cell)
SRR189784SRR038854(GSM458537)
MM653. (cell line)
SRR033730(GSM497075)
Lymphoblastic (ALL411). (B cell)
SRR033714(GSM497059)
Burkitt Lymphoma (BL134). (B cell)
SRR038861(GSM458544)
MM466. (cell line)
SRR039191(GSM494810)
PBMCs were isolated by ficoll gradient from t. (blood)
SRR037938(GSM510476)
293Red. (cell line)
SRR326280(GSM769510)
total cell content of unperturbed cells was s. (cell line)
SRR033720(GSM497065)
EBV activated B cell line (EBV159). (B cell)
TAX577740(Rovira)
total RNA. (breast)
SRR387909(GSM843861)
specific-host: Homo sapienshost cell line: Su. (cell line)
GSM450598(GSM450598)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR037933(GSM510471)
293cand4_rep2. (cell line)
SRR015364(GSM380329)
Plasma B cells (PC44). (B cell)
SRR189787SRR038860(GSM458543)
MM426. (cell line)
SRR033712(GSM497057)
Burkitt Lymphoma (BL510). (B cell)
GSM450602(GSM450602)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR037942(GSM510480)
293DroshaTN_cand5. (cell line)
SRR029054(GSM402329)
MCF7_smallRNAseq. (cell line)
SRR037943(GSM510481)
293DcrTN. (cell line)
SRR207116(GSM721078)
Nuclear RNA. (cell line)
GSM450610(GSM450610)
miRNA sequencing raw reads from post-mortem s. (brain)
TAX577742(Rovira)
total RNA. (breast)
SRR033729(GSM497074)
splenic MZL (Splenic414). (B cell)
SRR207115(GSM721077)
XRN1&2 knockdown. (XRN1/XRN2 cell line)
GSM339996(GSM339996)
hues6Neuron. (cell line)
SRR033725(GSM497070)
Unmutated CLL (CLLU626). (B cell)
SRR444049(SRX128897)
Sample 9cDNABarcode: AF-PP-334: ACG CTC TTC C. (skin)
SRR033726(GSM497071)
Mututated CLL (CLLM633). (B cell)
SRR040028(GSM532913)
G026N. (cervix)
SRR330877(SRX091715)
tissue: skin psoriatic involveddisease state:. (skin)
GSM450600(GSM450600)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR330867(SRX091705)
tissue: skin psoriatic involveddisease state:. (skin)
SRR033727(GSM497072)
HIV-positive DL (HIV412). (B cell)
TAX577739(Rovira)
total RNA. (breast)
SRR039613(GSM531976)
Human Normal Liver Tissue Sample 3. (liver)
SRR039636(GSM518473)
THP1_cyto_sRNAs. (cell line)
SRR037934(GSM510472)
293cand4_rep3. (cell line)
TAX577741(Rovira)
total RNA. (breast)
SRR390724(GSM850203)
small rna immunoprecipitated. (cell line)
SRR326282(GSM769512)
"Dicer mRNA was knocked down using siDicer, t. (cell line)
GSM450599(GSM450599)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR330890(SRX091728)
tissue: skin psoriatic uninvolveddisease stat. (skin)
GSM1105749AGO2(GSM1105749)
small RNA sequencing data. (ago2 hela)
SRR040022(GSM532907)
G575N. (cervix)
SRR033732(GSM497077)
bjab cell line (bjab103). (B cell)
SRR037936(GSM510474)
293cand1. (cell line)
SRR015446(SRR015446)
smallRNAs high-throughput sequencing Total. (breast)
SRR326279(GSM769509)
cytoplasmic fraction was isolated using PARIS. (cell line)
TAX577590(Rovira)
total RNA. (breast)
SRR191492(GSM715602)
154genomic small RNA (size selected RNA from . (breast)
SRR342897(SRX096793)
small RNA seq of Left atrial tissue. (heart)
SRR060986(GSM569190)
Human memory B cell [09-001]. (cell line)
GSM450609(GSM450609)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM450605(GSM450605)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM1105753INPUT(GSM1105753)
small RNA sequencing data. (hela)
SRR038856(GSM458539)
D11. (cell line)
SRR107297(GSM677704)
18-30nt fraction of small RNA. (cell line)
SRR038862(GSM458545)
MM472. (cell line)
SRR207118(GSM721080)
RRP40 knockdown. (RRP40 cell line)
TAX577588(Rovira)
total RNA. (breast)
SRR037935(GSM510473)
293cand3. (cell line)
SRR039193(GSM494812)
HL60 cell line is derived from acute promyelo. (cell line)
DRR001486(DRX001040)
"Hela long cytoplasmic cell fraction, LNA(+)". (hela)
SRR039635(GSM518472)
THP1_nuc_sRNAs. (cell line)
SRR191421(GSM715531)
122genomic small RNA (size selected RNA from . (breast)
SRR015448(SRR015448)
cytoplasmic small RNAs. (breast)
SRR039615(GSM531978)
Severe Chronic Hepatitis B Liver Tissue. (liver)
SRR037944(GSM510482)
293DcrTN_cand5. (cell line)
SRR029126(GSM416755)
143B. (cell line)
SRR039620(GSM531983)
HBV(+) Adjacent Tissue Sample 2. (liver)
SRR191562(GSM715672)
82genomic small RNA (size selected RNA from t. (breast)
SRR189778(GSM714638)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR033713(GSM497058)
Burkitt Lymphoma (BL115). (B cell)
SRR060981(GSM569185)
Human centroblast [09-001]. (cell line)
SRR330904(SRX091742)
tissue: normal skindisease state: normal. (skin)
SRR015358(GSM380323)
NaÌøve B Cell (Naive39). (B cell)
SRR094130(GSM651906)
small RNA(18-35nt)small RNA deep sequencing o. (uterus)
SRR330868(SRX091706)
tissue: skin psoriatic involveddisease state:. (skin)
SRR189785SRR330897(SRX091735)
tissue: skin psoriatic uninvolveddisease stat. (skin)
SRR038855(GSM458538)
D10. (cell line)
TAX577579(Rovira)
total RNA. (breast)
TAX577743(Rovira)
total RNA. (breast)
SRR039192(GSM494811)
K562 cell line is derived from a CML patient . (cell line)
SRR040031(GSM532916)
G013T. (cervix)
SRR189781(GSM714641)
cell line: HEK293clip variant: PAR-CLIPenzyma. (cell line)
SRR033721(GSM497066)
Ly3 cell line (Ly3). (B cell)
GSM450601(GSM450601)
miRNA sequencing raw reads from post-mortem s. (brain)
GSM450604(GSM450604)
miRNA sequencing raw reads from post-mortem s. (brain)
SRR060982(GSM569186)
Human centrocyte [09-001]. (cell line)
SRR330880(SRX091718)
tissue: skin psoriatic involveddisease state:. (skin)
..........................................................................................GGCTGGAGTGCAATGGCGCGATGGGA...................................................................................................................................... 262.000.00---1.00-1.00---------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGAGGCT....................................................................................................................................... 251.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATGACG...................................................................................................................................... 261.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................TCAGGTTCTGTTCACAA.................................................................................. 171.000.00-------------------------------------------------------------------------------------------------------------------1.00-------------------
..............................................................................................................................................................................GCATCAGGTTCGGAC............................................................. 1511.001.00-------------------------------------------------------------------------1.00-------------------------------------------------------------
........................................................................................CAGGCTGGAGTGCAATGGCGCGATCTTCTC.................................................................................................................................... 301.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATCTGGGA.................................................................................................................................... 281.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATGGCA...................................................................................................................................... 261.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATGGTC...................................................................................................................................... 261.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATGGAC...................................................................................................................................... 261.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATGTC....................................................................................................................................... 251.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------
.......................................................................................................................................................TCAGGTTCTGTTCACAGGG................................................................................ 1911.001.00----------------------------------------------------------------------------------------------------------------------1.00----------------
..........................................................................................GGCTGGAGTGCAATGGCGCGATCTGGAC.................................................................................................................................... 281.000.00---1.00-----------------------------------------------------------------------------------------------------------------------------------